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Protein

1_1_36S_FusoPortal_Gene_108

Length

280 amino acids

Protein family membership

Pantoate-beta-alanine ligase (IPR003721)

Homologous superfamilies

Homologous superfamily
1 - 173
Rossmann-like alpha/beta/alpha sandwich fold (IPR014729)

1 50 100 150 200 250 280

Domains and repeats

None predicted.

Detailed signature matches

IPR014729

Rossmann-like alpha/beta/alpha sandwich fold

G3DSA:3.40.50...

1 - 173

GENE3D
G3DSA:3.40.50.620 (G3DSA:3.40.50.620)

IPR003721

Pantoate-beta-alanine ligase

MF_00158 (PanC)

2 - 277

HAMAP
MF_00158 (PanC)
cd00560 (PanC)

1 - 275

CDD
cd00560 (PanC)
PTHR21299:SF1 (PANT...)

2 - 278

PANTHER
PTHR21299:SF1 (PANTOATE--BETA-ALANINE LIGASE)
PF02569 (Pantoate_l...)

2 - 275

Pfam
PF02569 (Pantoate_ligase)
TIGR00018

1 - 277

TIGRFAMs
TIGR00018 (TIGR00018)

no IPR

Unintegrated signatures

G3DSA:3.30.13...

174 - 280

GENE3D
G3DSA:3.30.1300.10 (G3DSA:3.30.1300.10)
PTHR21299 (CYTIDYLA...)

2 - 278

PANTHER
PTHR21299 (CYTIDYLATE KINASE/PANTOATE-BETA-ALANINE LIGASE)
SSF52374 (Nucleotid...)

1 - 277

SUPERFAMILY
SSF52374 (Nucleotidylyl transferase)

Residue annotation

pantoate-binding s...

28P

pantoate-binding site
28P, 30M, 58N, 61Q, 130V, 131V, 134L, 152Q
CDD
cd00560 (PanC)

30M

pantoate-binding site
28P, 30M, 58N, 61Q, 130V, 131V, 134L, 152Q
CDD
cd00560 (PanC)

58N

pantoate-binding site
28P, 30M, 58N, 61Q, 130V, 131V, 134L, 152Q
CDD
cd00560 (PanC)

61Q

pantoate-binding site
28P, 30M, 58N, 61Q, 130V, 131V, 134L, 152Q
CDD
cd00560 (PanC)

130V

pantoate-binding site
28P, 30M, 58N, 61Q, 130V, 131V, 134L, 152Q
CDD
cd00560 (PanC)

131V

pantoate-binding site
28P, 30M, 58N, 61Q, 130V, 131V, 134L, 152Q
CDD
cd00560 (PanC)

134L

pantoate-binding site
28P, 30M, 58N, 61Q, 130V, 131V, 134L, 152Q
CDD
cd00560 (PanC)

152Q

pantoate-binding site
28P, 30M, 58N, 61Q, 130V, 131V, 134L, 152Q
CDD
cd00560 (PanC)
ATP-binding site c...

28P

ATP-binding site
28P, 29S, 30M, 34H, 37H, 40L, 61Q, 130V, 131V, 145F, 146G, 148K, 149D, 152Q, 174I, 175V, 182A, 183K
CDD
cd00560 (PanC)

29S

ATP-binding site
28P, 29S, 30M, 34H, 37H, 40L, 61Q, 130V, 131V, 145F, 146G, 148K, 149D, 152Q, 174I, 175V, 182A, 183K
CDD
cd00560 (PanC)

30M

ATP-binding site
28P, 29S, 30M, 34H, 37H, 40L, 61Q, 130V, 131V, 145F, 146G, 148K, 149D, 152Q, 174I, 175V, 182A, 183K
CDD
cd00560 (PanC)

34H

ATP-binding site
28P, 29S, 30M, 34H, 37H, 40L, 61Q, 130V, 131V, 145F, 146G, 148K, 149D, 152Q, 174I, 175V, 182A, 183K
CDD
cd00560 (PanC)

37H

ATP-binding site
28P, 29S, 30M, 34H, 37H, 40L, 61Q, 130V, 131V, 145F, 146G, 148K, 149D, 152Q, 174I, 175V, 182A, 183K
CDD
cd00560 (PanC)

40L

ATP-binding site
28P, 29S, 30M, 34H, 37H, 40L, 61Q, 130V, 131V, 145F, 146G, 148K, 149D, 152Q, 174I, 175V, 182A, 183K
CDD
cd00560 (PanC)

61Q

ATP-binding site
28P, 29S, 30M, 34H, 37H, 40L, 61Q, 130V, 131V, 145F, 146G, 148K, 149D, 152Q, 174I, 175V, 182A, 183K
CDD
cd00560 (PanC)

130V

ATP-binding site
28P, 29S, 30M, 34H, 37H, 40L, 61Q, 130V, 131V, 145F, 146G, 148K, 149D, 152Q, 174I, 175V, 182A, 183K
CDD
cd00560 (PanC)

131V

ATP-binding site
28P, 29S, 30M, 34H, 37H, 40L, 61Q, 130V, 131V, 145F, 146G, 148K, 149D, 152Q, 174I, 175V, 182A, 183K
CDD
cd00560 (PanC)

145F

ATP-binding site
28P, 29S, 30M, 34H, 37H, 40L, 61Q, 130V, 131V, 145F, 146G, 148K, 149D, 152Q, 174I, 175V, 182A, 183K
CDD
cd00560 (PanC)

146G

ATP-binding site
28P, 29S, 30M, 34H, 37H, 40L, 61Q, 130V, 131V, 145F, 146G, 148K, 149D, 152Q, 174I, 175V, 182A, 183K
CDD
cd00560 (PanC)

148K

ATP-binding site
28P, 29S, 30M, 34H, 37H, 40L, 61Q, 130V, 131V, 145F, 146G, 148K, 149D, 152Q, 174I, 175V, 182A, 183K
CDD
cd00560 (PanC)

149D

ATP-binding site
28P, 29S, 30M, 34H, 37H, 40L, 61Q, 130V, 131V, 145F, 146G, 148K, 149D, 152Q, 174I, 175V, 182A, 183K
CDD
cd00560 (PanC)

152Q

ATP-binding site
28P, 29S, 30M, 34H, 37H, 40L, 61Q, 130V, 131V, 145F, 146G, 148K, 149D, 152Q, 174I, 175V, 182A, 183K
CDD
cd00560 (PanC)

174I

ATP-binding site
28P, 29S, 30M, 34H, 37H, 40L, 61Q, 130V, 131V, 145F, 146G, 148K, 149D, 152Q, 174I, 175V, 182A, 183K
CDD
cd00560 (PanC)

175V

ATP-binding site
28P, 29S, 30M, 34H, 37H, 40L, 61Q, 130V, 131V, 145F, 146G, 148K, 149D, 152Q, 174I, 175V, 182A, 183K
CDD
cd00560 (PanC)

182A

ATP-binding site
28P, 29S, 30M, 34H, 37H, 40L, 61Q, 130V, 131V, 145F, 146G, 148K, 149D, 152Q, 174I, 175V, 182A, 183K
CDD
cd00560 (PanC)

183K

ATP-binding site
28P, 29S, 30M, 34H, 37H, 40L, 61Q, 130V, 131V, 145F, 146G, 148K, 149D, 152Q, 174I, 175V, 182A, 183K
CDD
cd00560 (PanC)
active site cd00560

28P

active site
28P, 29S, 30M, 31G, 34H, 36G, 37H, 40L, 58N, 61Q, 71Y, 127V, 130V, 131V, 145F, 146G, 148K, 149D, 152Q, 173P, 174I, 175V, 183K, 184S, 185S, 186R
CDD
cd00560 (PanC)

29S

active site
28P, 29S, 30M, 31G, 34H, 36G, 37H, 40L, 58N, 61Q, 71Y, 127V, 130V, 131V, 145F, 146G, 148K, 149D, 152Q, 173P, 174I, 175V, 183K, 184S, 185S, 186R
CDD
cd00560 (PanC)

30M

active site
28P, 29S, 30M, 31G, 34H, 36G, 37H, 40L, 58N, 61Q, 71Y, 127V, 130V, 131V, 145F, 146G, 148K, 149D, 152Q, 173P, 174I, 175V, 183K, 184S, 185S, 186R
CDD
cd00560 (PanC)

31G

active site
28P, 29S, 30M, 31G, 34H, 36G, 37H, 40L, 58N, 61Q, 71Y, 127V, 130V, 131V, 145F, 146G, 148K, 149D, 152Q, 173P, 174I, 175V, 183K, 184S, 185S, 186R
CDD
cd00560 (PanC)

34H

active site
28P, 29S, 30M, 31G, 34H, 36G, 37H, 40L, 58N, 61Q, 71Y, 127V, 130V, 131V, 145F, 146G, 148K, 149D, 152Q, 173P, 174I, 175V, 183K, 184S, 185S, 186R
CDD
cd00560 (PanC)

36G

active site
28P, 29S, 30M, 31G, 34H, 36G, 37H, 40L, 58N, 61Q, 71Y, 127V, 130V, 131V, 145F, 146G, 148K, 149D, 152Q, 173P, 174I, 175V, 183K, 184S, 185S, 186R
CDD
cd00560 (PanC)

37H

active site
28P, 29S, 30M, 31G, 34H, 36G, 37H, 40L, 58N, 61Q, 71Y, 127V, 130V, 131V, 145F, 146G, 148K, 149D, 152Q, 173P, 174I, 175V, 183K, 184S, 185S, 186R
CDD
cd00560 (PanC)

40L

active site
28P, 29S, 30M, 31G, 34H, 36G, 37H, 40L, 58N, 61Q, 71Y, 127V, 130V, 131V, 145F, 146G, 148K, 149D, 152Q, 173P, 174I, 175V, 183K, 184S, 185S, 186R
CDD
cd00560 (PanC)

58N

active site
28P, 29S, 30M, 31G, 34H, 36G, 37H, 40L, 58N, 61Q, 71Y, 127V, 130V, 131V, 145F, 146G, 148K, 149D, 152Q, 173P, 174I, 175V, 183K, 184S, 185S, 186R
CDD
cd00560 (PanC)

61Q

active site
28P, 29S, 30M, 31G, 34H, 36G, 37H, 40L, 58N, 61Q, 71Y, 127V, 130V, 131V, 145F, 146G, 148K, 149D, 152Q, 173P, 174I, 175V, 183K, 184S, 185S, 186R
CDD
cd00560 (PanC)

71Y

active site
28P, 29S, 30M, 31G, 34H, 36G, 37H, 40L, 58N, 61Q, 71Y, 127V, 130V, 131V, 145F, 146G, 148K, 149D, 152Q, 173P, 174I, 175V, 183K, 184S, 185S, 186R
CDD
cd00560 (PanC)

127V

active site
28P, 29S, 30M, 31G, 34H, 36G, 37H, 40L, 58N, 61Q, 71Y, 127V, 130V, 131V, 145F, 146G, 148K, 149D, 152Q, 173P, 174I, 175V, 183K, 184S, 185S, 186R
CDD
cd00560 (PanC)

130V

active site
28P, 29S, 30M, 31G, 34H, 36G, 37H, 40L, 58N, 61Q, 71Y, 127V, 130V, 131V, 145F, 146G, 148K, 149D, 152Q, 173P, 174I, 175V, 183K, 184S, 185S, 186R
CDD
cd00560 (PanC)

131V

active site
28P, 29S, 30M, 31G, 34H, 36G, 37H, 40L, 58N, 61Q, 71Y, 127V, 130V, 131V, 145F, 146G, 148K, 149D, 152Q, 173P, 174I, 175V, 183K, 184S, 185S, 186R
CDD
cd00560 (PanC)

145F

active site
28P, 29S, 30M, 31G, 34H, 36G, 37H, 40L, 58N, 61Q, 71Y, 127V, 130V, 131V, 145F, 146G, 148K, 149D, 152Q, 173P, 174I, 175V, 183K, 184S, 185S, 186R
CDD
cd00560 (PanC)

146G

active site
28P, 29S, 30M, 31G, 34H, 36G, 37H, 40L, 58N, 61Q, 71Y, 127V, 130V, 131V, 145F, 146G, 148K, 149D, 152Q, 173P, 174I, 175V, 183K, 184S, 185S, 186R
CDD
cd00560 (PanC)

148K

active site
28P, 29S, 30M, 31G, 34H, 36G, 37H, 40L, 58N, 61Q, 71Y, 127V, 130V, 131V, 145F, 146G, 148K, 149D, 152Q, 173P, 174I, 175V, 183K, 184S, 185S, 186R
CDD
cd00560 (PanC)

149D

active site
28P, 29S, 30M, 31G, 34H, 36G, 37H, 40L, 58N, 61Q, 71Y, 127V, 130V, 131V, 145F, 146G, 148K, 149D, 152Q, 173P, 174I, 175V, 183K, 184S, 185S, 186R
CDD
cd00560 (PanC)

152Q

active site
28P, 29S, 30M, 31G, 34H, 36G, 37H, 40L, 58N, 61Q, 71Y, 127V, 130V, 131V, 145F, 146G, 148K, 149D, 152Q, 173P, 174I, 175V, 183K, 184S, 185S, 186R
CDD
cd00560 (PanC)

173P

active site
28P, 29S, 30M, 31G, 34H, 36G, 37H, 40L, 58N, 61Q, 71Y, 127V, 130V, 131V, 145F, 146G, 148K, 149D, 152Q, 173P, 174I, 175V, 183K, 184S, 185S, 186R
CDD
cd00560 (PanC)

174I

active site
28P, 29S, 30M, 31G, 34H, 36G, 37H, 40L, 58N, 61Q, 71Y, 127V, 130V, 131V, 145F, 146G, 148K, 149D, 152Q, 173P, 174I, 175V, 183K, 184S, 185S, 186R
CDD
cd00560 (PanC)

175V

active site
28P, 29S, 30M, 31G, 34H, 36G, 37H, 40L, 58N, 61Q, 71Y, 127V, 130V, 131V, 145F, 146G, 148K, 149D, 152Q, 173P, 174I, 175V, 183K, 184S, 185S, 186R
CDD
cd00560 (PanC)

183K

active site
28P, 29S, 30M, 31G, 34H, 36G, 37H, 40L, 58N, 61Q, 71Y, 127V, 130V, 131V, 145F, 146G, 148K, 149D, 152Q, 173P, 174I, 175V, 183K, 184S, 185S, 186R
CDD
cd00560 (PanC)

184S

active site
28P, 29S, 30M, 31G, 34H, 36G, 37H, 40L, 58N, 61Q, 71Y, 127V, 130V, 131V, 145F, 146G, 148K, 149D, 152Q, 173P, 174I, 175V, 183K, 184S, 185S, 186R
CDD
cd00560 (PanC)

185S

active site
28P, 29S, 30M, 31G, 34H, 36G, 37H, 40L, 58N, 61Q, 71Y, 127V, 130V, 131V, 145F, 146G, 148K, 149D, 152Q, 173P, 174I, 175V, 183K, 184S, 185S, 186R
CDD
cd00560 (PanC)

186R

active site
28P, 29S, 30M, 31G, 34H, 36G, 37H, 40L, 58N, 61Q, 71Y, 127V, 130V, 131V, 145F, 146G, 148K, 149D, 152Q, 173P, 174I, 175V, 183K, 184S, 185S, 186R
CDD
cd00560 (PanC)
HXXH motif cd00560

34H

HXXH motif
34H, 35E, 36G, 37H
CDD
cd00560 (PanC)

35E

HXXH motif
34H, 35E, 36G, 37H
CDD
cd00560 (PanC)

36G

HXXH motif
34H, 35E, 36G, 37H
CDD
cd00560 (PanC)

37H

HXXH motif
34H, 35E, 36G, 37H
CDD
cd00560 (PanC)

GO term prediction

Biological Process

GO:0015940 pantothenate biosynthetic process

Molecular Function

GO:0004592 pantoate-beta-alanine ligase activity

Cellular Component

None predicted.

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Entry type

Status

Per-residue features

1_1_36S_FusoPortal_Gene_108

Protein family membership

Homologous superfamilies

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component