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Protein

1_1_36S_FusoPortal_Gene_1110

Length

261 amino acids

Protein family membership

Crotonase superfamily (IPR001753)

Homologous superfamilies

Homologous superfamily
2 - 260
ClpP/crotonase-like domain superfamily (IPR029045)
Homologous superfamily
222 - 259
Crontonase, C-terminal (IPR014748)

1 50 100 150 200 261

Domains and repeats

None predicted.

Detailed signature matches

IPR029045

ClpP/crotonase-like domain superfamily

SSF52096 (ClpP/crot...)

2 - 260

SUPERFAMILY
SSF52096 (ClpP/crotonase)

IPR014748

Crontonase, C-terminal

G3DSA:1.10.12.10

222 - 259

GENE3D
G3DSA:1.10.12.10 (G3DSA:1.10.12.10)

IPR001753

Crotonase superfamily

PF00378 (ECH_1)

12 - 260

Pfam
PF00378 (ECH_1)

IPR018376

Enoyl-CoA hydratase/isomerase, conserved site

PS00166 (ENOYL_COA_...)

102 - 122

PROSITE patterns
PS00166 (ENOYL_COA_HYDRATASE)

no IPR

Unintegrated signatures

Coil

183 - 203

COILS
Coil (Coil)
G3DSA:3.90.22...

4 - 221

GENE3D
G3DSA:3.90.226.10 (G3DSA:3.90.226.10)
PTHR11941 (ENOYL-CO...)

13 - 256

PANTHER
PTHR11941 (ENOYL-COA HYDRATASE-RELATED)
PTHR11941:SF54 (ENO...)

13 - 256

PANTHER
PTHR11941:SF54 (ENOYL-COA HYDRATASE, MITOCHONDRIAL)
cd06558 (crotonase-...)

8 - 200

CDD
cd06558 (crotonase-like)

Residue annotation

substrate binding ...

27L

substrate binding site
27L, 29A, 61K, 65A, 66G, 67A, 68D, 69I, 108Y, 110L, 111G, 112G, 134P, 135E, 138L
CDD
cd06558 (crotonase-like)

29A

substrate binding site
27L, 29A, 61K, 65A, 66G, 67A, 68D, 69I, 108Y, 110L, 111G, 112G, 134P, 135E, 138L
CDD
cd06558 (crotonase-like)

61K

substrate binding site
27L, 29A, 61K, 65A, 66G, 67A, 68D, 69I, 108Y, 110L, 111G, 112G, 134P, 135E, 138L
CDD
cd06558 (crotonase-like)

65A

substrate binding site
27L, 29A, 61K, 65A, 66G, 67A, 68D, 69I, 108Y, 110L, 111G, 112G, 134P, 135E, 138L
CDD
cd06558 (crotonase-like)

66G

substrate binding site
27L, 29A, 61K, 65A, 66G, 67A, 68D, 69I, 108Y, 110L, 111G, 112G, 134P, 135E, 138L
CDD
cd06558 (crotonase-like)

67A

substrate binding site
27L, 29A, 61K, 65A, 66G, 67A, 68D, 69I, 108Y, 110L, 111G, 112G, 134P, 135E, 138L
CDD
cd06558 (crotonase-like)

68D

substrate binding site
27L, 29A, 61K, 65A, 66G, 67A, 68D, 69I, 108Y, 110L, 111G, 112G, 134P, 135E, 138L
CDD
cd06558 (crotonase-like)

69I

substrate binding site
27L, 29A, 61K, 65A, 66G, 67A, 68D, 69I, 108Y, 110L, 111G, 112G, 134P, 135E, 138L
CDD
cd06558 (crotonase-like)

108Y

substrate binding site
27L, 29A, 61K, 65A, 66G, 67A, 68D, 69I, 108Y, 110L, 111G, 112G, 134P, 135E, 138L
CDD
cd06558 (crotonase-like)

110L

substrate binding site
27L, 29A, 61K, 65A, 66G, 67A, 68D, 69I, 108Y, 110L, 111G, 112G, 134P, 135E, 138L
CDD
cd06558 (crotonase-like)

111G

substrate binding site
27L, 29A, 61K, 65A, 66G, 67A, 68D, 69I, 108Y, 110L, 111G, 112G, 134P, 135E, 138L
CDD
cd06558 (crotonase-like)

112G

substrate binding site
27L, 29A, 61K, 65A, 66G, 67A, 68D, 69I, 108Y, 110L, 111G, 112G, 134P, 135E, 138L
CDD
cd06558 (crotonase-like)

134P

substrate binding site
27L, 29A, 61K, 65A, 66G, 67A, 68D, 69I, 108Y, 110L, 111G, 112G, 134P, 135E, 138L
CDD
cd06558 (crotonase-like)

135E

substrate binding site
27L, 29A, 61K, 65A, 66G, 67A, 68D, 69I, 108Y, 110L, 111G, 112G, 134P, 135E, 138L
CDD
cd06558 (crotonase-like)

138L

substrate binding site
27L, 29A, 61K, 65A, 66G, 67A, 68D, 69I, 108Y, 110L, 111G, 112G, 134P, 135E, 138L
CDD
cd06558 (crotonase-like)
oxyanion hole (OAH...

67A

oxyanion hole (OAH) forming residues
67A, 112G
CDD
cd06558 (crotonase-like)

112G

oxyanion hole (OAH) forming residues
67A, 112G
CDD
cd06558 (crotonase-like)
trimer interface c...

92N

trimer interface
92N, 100P, 121D, 122I, 123R, 124I, 136V, 137N, 138L, 139G, 145G, 147T, 148Q, 149R, 151S, 152R, 157G, 158I, 160K, 161E, 163I, 164F, 167D, 178G, 181N, 196M, 199K, 200I
CDD
cd06558 (crotonase-like)

100P

trimer interface
92N, 100P, 121D, 122I, 123R, 124I, 136V, 137N, 138L, 139G, 145G, 147T, 148Q, 149R, 151S, 152R, 157G, 158I, 160K, 161E, 163I, 164F, 167D, 178G, 181N, 196M, 199K, 200I
CDD
cd06558 (crotonase-like)

121D

trimer interface
92N, 100P, 121D, 122I, 123R, 124I, 136V, 137N, 138L, 139G, 145G, 147T, 148Q, 149R, 151S, 152R, 157G, 158I, 160K, 161E, 163I, 164F, 167D, 178G, 181N, 196M, 199K, 200I
CDD
cd06558 (crotonase-like)

122I

trimer interface
92N, 100P, 121D, 122I, 123R, 124I, 136V, 137N, 138L, 139G, 145G, 147T, 148Q, 149R, 151S, 152R, 157G, 158I, 160K, 161E, 163I, 164F, 167D, 178G, 181N, 196M, 199K, 200I
CDD
cd06558 (crotonase-like)

123R

trimer interface
92N, 100P, 121D, 122I, 123R, 124I, 136V, 137N, 138L, 139G, 145G, 147T, 148Q, 149R, 151S, 152R, 157G, 158I, 160K, 161E, 163I, 164F, 167D, 178G, 181N, 196M, 199K, 200I
CDD
cd06558 (crotonase-like)

124I

trimer interface
92N, 100P, 121D, 122I, 123R, 124I, 136V, 137N, 138L, 139G, 145G, 147T, 148Q, 149R, 151S, 152R, 157G, 158I, 160K, 161E, 163I, 164F, 167D, 178G, 181N, 196M, 199K, 200I
CDD
cd06558 (crotonase-like)

136V

trimer interface
92N, 100P, 121D, 122I, 123R, 124I, 136V, 137N, 138L, 139G, 145G, 147T, 148Q, 149R, 151S, 152R, 157G, 158I, 160K, 161E, 163I, 164F, 167D, 178G, 181N, 196M, 199K, 200I
CDD
cd06558 (crotonase-like)

137N

trimer interface
92N, 100P, 121D, 122I, 123R, 124I, 136V, 137N, 138L, 139G, 145G, 147T, 148Q, 149R, 151S, 152R, 157G, 158I, 160K, 161E, 163I, 164F, 167D, 178G, 181N, 196M, 199K, 200I
CDD
cd06558 (crotonase-like)

138L

trimer interface
92N, 100P, 121D, 122I, 123R, 124I, 136V, 137N, 138L, 139G, 145G, 147T, 148Q, 149R, 151S, 152R, 157G, 158I, 160K, 161E, 163I, 164F, 167D, 178G, 181N, 196M, 199K, 200I
CDD
cd06558 (crotonase-like)

139G

trimer interface
92N, 100P, 121D, 122I, 123R, 124I, 136V, 137N, 138L, 139G, 145G, 147T, 148Q, 149R, 151S, 152R, 157G, 158I, 160K, 161E, 163I, 164F, 167D, 178G, 181N, 196M, 199K, 200I
CDD
cd06558 (crotonase-like)

145G

trimer interface
92N, 100P, 121D, 122I, 123R, 124I, 136V, 137N, 138L, 139G, 145G, 147T, 148Q, 149R, 151S, 152R, 157G, 158I, 160K, 161E, 163I, 164F, 167D, 178G, 181N, 196M, 199K, 200I
CDD
cd06558 (crotonase-like)

147T

trimer interface
92N, 100P, 121D, 122I, 123R, 124I, 136V, 137N, 138L, 139G, 145G, 147T, 148Q, 149R, 151S, 152R, 157G, 158I, 160K, 161E, 163I, 164F, 167D, 178G, 181N, 196M, 199K, 200I
CDD
cd06558 (crotonase-like)

148Q

trimer interface
92N, 100P, 121D, 122I, 123R, 124I, 136V, 137N, 138L, 139G, 145G, 147T, 148Q, 149R, 151S, 152R, 157G, 158I, 160K, 161E, 163I, 164F, 167D, 178G, 181N, 196M, 199K, 200I
CDD
cd06558 (crotonase-like)

149R

trimer interface
92N, 100P, 121D, 122I, 123R, 124I, 136V, 137N, 138L, 139G, 145G, 147T, 148Q, 149R, 151S, 152R, 157G, 158I, 160K, 161E, 163I, 164F, 167D, 178G, 181N, 196M, 199K, 200I
CDD
cd06558 (crotonase-like)

151S

trimer interface
92N, 100P, 121D, 122I, 123R, 124I, 136V, 137N, 138L, 139G, 145G, 147T, 148Q, 149R, 151S, 152R, 157G, 158I, 160K, 161E, 163I, 164F, 167D, 178G, 181N, 196M, 199K, 200I
CDD
cd06558 (crotonase-like)

152R

trimer interface
92N, 100P, 121D, 122I, 123R, 124I, 136V, 137N, 138L, 139G, 145G, 147T, 148Q, 149R, 151S, 152R, 157G, 158I, 160K, 161E, 163I, 164F, 167D, 178G, 181N, 196M, 199K, 200I
CDD
cd06558 (crotonase-like)

157G

trimer interface
92N, 100P, 121D, 122I, 123R, 124I, 136V, 137N, 138L, 139G, 145G, 147T, 148Q, 149R, 151S, 152R, 157G, 158I, 160K, 161E, 163I, 164F, 167D, 178G, 181N, 196M, 199K, 200I
CDD
cd06558 (crotonase-like)

158I

trimer interface
92N, 100P, 121D, 122I, 123R, 124I, 136V, 137N, 138L, 139G, 145G, 147T, 148Q, 149R, 151S, 152R, 157G, 158I, 160K, 161E, 163I, 164F, 167D, 178G, 181N, 196M, 199K, 200I
CDD
cd06558 (crotonase-like)

160K

trimer interface
92N, 100P, 121D, 122I, 123R, 124I, 136V, 137N, 138L, 139G, 145G, 147T, 148Q, 149R, 151S, 152R, 157G, 158I, 160K, 161E, 163I, 164F, 167D, 178G, 181N, 196M, 199K, 200I
CDD
cd06558 (crotonase-like)

161E

trimer interface
92N, 100P, 121D, 122I, 123R, 124I, 136V, 137N, 138L, 139G, 145G, 147T, 148Q, 149R, 151S, 152R, 157G, 158I, 160K, 161E, 163I, 164F, 167D, 178G, 181N, 196M, 199K, 200I
CDD
cd06558 (crotonase-like)

163I

trimer interface
92N, 100P, 121D, 122I, 123R, 124I, 136V, 137N, 138L, 139G, 145G, 147T, 148Q, 149R, 151S, 152R, 157G, 158I, 160K, 161E, 163I, 164F, 167D, 178G, 181N, 196M, 199K, 200I
CDD
cd06558 (crotonase-like)

164F

trimer interface
92N, 100P, 121D, 122I, 123R, 124I, 136V, 137N, 138L, 139G, 145G, 147T, 148Q, 149R, 151S, 152R, 157G, 158I, 160K, 161E, 163I, 164F, 167D, 178G, 181N, 196M, 199K, 200I
CDD
cd06558 (crotonase-like)

167D

trimer interface
92N, 100P, 121D, 122I, 123R, 124I, 136V, 137N, 138L, 139G, 145G, 147T, 148Q, 149R, 151S, 152R, 157G, 158I, 160K, 161E, 163I, 164F, 167D, 178G, 181N, 196M, 199K, 200I
CDD
cd06558 (crotonase-like)

178G

trimer interface
92N, 100P, 121D, 122I, 123R, 124I, 136V, 137N, 138L, 139G, 145G, 147T, 148Q, 149R, 151S, 152R, 157G, 158I, 160K, 161E, 163I, 164F, 167D, 178G, 181N, 196M, 199K, 200I
CDD
cd06558 (crotonase-like)

181N

trimer interface
92N, 100P, 121D, 122I, 123R, 124I, 136V, 137N, 138L, 139G, 145G, 147T, 148Q, 149R, 151S, 152R, 157G, 158I, 160K, 161E, 163I, 164F, 167D, 178G, 181N, 196M, 199K, 200I
CDD
cd06558 (crotonase-like)

196M

trimer interface
92N, 100P, 121D, 122I, 123R, 124I, 136V, 137N, 138L, 139G, 145G, 147T, 148Q, 149R, 151S, 152R, 157G, 158I, 160K, 161E, 163I, 164F, 167D, 178G, 181N, 196M, 199K, 200I
CDD
cd06558 (crotonase-like)

199K

trimer interface
92N, 100P, 121D, 122I, 123R, 124I, 136V, 137N, 138L, 139G, 145G, 147T, 148Q, 149R, 151S, 152R, 157G, 158I, 160K, 161E, 163I, 164F, 167D, 178G, 181N, 196M, 199K, 200I
CDD
cd06558 (crotonase-like)

200I

trimer interface
92N, 100P, 121D, 122I, 123R, 124I, 136V, 137N, 138L, 139G, 145G, 147T, 148Q, 149R, 151S, 152R, 157G, 158I, 160K, 161E, 163I, 164F, 167D, 178G, 181N, 196M, 199K, 200I
CDD
cd06558 (crotonase-like)

GO term prediction

Biological Process

GO:0008152 metabolic process

Molecular Function

GO:0003824 catalytic activity

Cellular Component

None predicted.

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Entry type

Status

Per-residue features

1_1_36S_FusoPortal_Gene_1110

Protein family membership

Homologous superfamilies

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component