1_1_36S_FusoPortal_Gene_1190

Protein

1_1_36S_FusoPortal_Gene_1190

Length

743 amino acids

Protein family membership

Polyribonucleotide nucleotidyltransferase (IPR012162)

Homologous superfamilies

Homologous superfamily
42 - 180
Ribosomal protein S5 domain 2-type fold (IPR020568)
338 - 533
Ribosomal protein S5 domain 2-type fold (IPR020568)
590 - 673
K Homology domain, type 1 superfamily (IPR036612)
Homologous superfamily
47 - 287
PNPase/RNase PH domain superfamily (IPR027408)
362 - 589
PNPase/RNase PH domain superfamily (IPR027408)
Homologous superfamily
174 - 266
Exoribonuclease, PH domain 2 superfamily (IPR036345)
275 - 365
Polyribonucleotide nucleotidyltransferase, RNA-binding domain superfamily (IPR036456)
495 - 589
Exoribonuclease, PH domain 2 superfamily (IPR036345)
653 - 737
Nucleic acid-binding, OB-fold (IPR012340)

1 100 200 300 400 500 600 743

Domains and repeats

Domain
50 - 180
Exoribonuclease, phosphorolytic domain 1 (IPR001247)
183 - 246
Exoribonuclease, phosphorolytic domain 2 (IPR015847)
279 - 365
Polyribonucleotide nucleotidyltransferase, RNA-binding domain (IPR015848)
368 - 501
Exoribonuclease, phosphorolytic domain 1 (IPR001247)
600 - 645
K Homology domain, type 1 (IPR004088)
664 - 733
S1 domain (IPR003029)

1 100 200 300 400 500 600 743

Detailed signature matches

IPR020568

Ribosomal protein S5 domain 2-type fold
1. SSF54211 (Ribosomal...)
  
  42 - 180
  
  SUPERFAMILY
  SSF54211 (Ribosomal protein S5 domain 2-like)
  
  338 - 533
  
  SUPERFAMILY
  SSF54211 (Ribosomal protein S5 domain 2-like)
IPR027408

PNPase/RNase PH domain superfamily
1. G3DSA:3.30.23...
  
  362 - 589
  
  GENE3D
  G3DSA:3.30.230.70 (G3DSA:3.30.230.70)
  
  47 - 287
  
  GENE3D
  G3DSA:3.30.230.70 (G3DSA:3.30.230.70)
IPR036345

Exoribonuclease, PH domain 2 superfamily
1. SSF55666 (Ribonucle...)
  
  495 - 589
  
  SUPERFAMILY
  SSF55666 (Ribonuclease PH domain 2-like)
  
  174 - 266
  
  SUPERFAMILY
  SSF55666 (Ribonuclease PH domain 2-like)
IPR036456

Polyribonucleotide nucleotidyltransferase, RNA-binding domain superfamily
1. G3DSA:1.10.10...
  
  288 - 361
  
  GENE3D
  G3DSA:1.10.10.400 (G3DSA:1.10.10.400)
2. SSF46915 (Polynucle...)
  
  275 - 365
  
  SUPERFAMILY
  SSF46915 (Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3)
IPR036612

K Homology domain, type 1 superfamily
1. G3DSA:3.30.13...
  
  590 - 661
  
  GENE3D
  G3DSA:3.30.1370.10 (G3DSA:3.30.1370.10)
2. SSF54791 (Eukaryoti...)
  
  597 - 673
  
  SUPERFAMILY
  SSF54791 (Eukaryotic type KH-domain (KH-domain type I))
IPR012340

Nucleic acid-binding, OB-fold
1. SSF50249 (Nucleic a...)
  
  653 - 737
  
  SUPERFAMILY
  SSF50249 (Nucleic acid-binding proteins)
IPR012162

Polyribonucleotide nucleotidyltransferase
1. TIGR03591
  
  47 - 734
  
  TIGRFAMs
  TIGR03591 (TIGR03591)
2. PTHR11252 (POLYRIBO...)
  
  39 - 736
  
  PANTHER
  PTHR11252 (POLYRIBONUCLEOTIDE NUCLEOTIDYLTRANSFERASE)
3. MF_01595 (PNPase)
  
  39 - 736
  
  HAMAP
  MF_01595 (PNPase)
4. PIRSF005499 (PNPase)
  
  37 - 743
  
  PIRSF
  PIRSF005499 (PNPase)
IPR001247

Exoribonuclease, phosphorolytic domain 1
1. PF01138 (RNase_PH)
  
  368 - 501
  
  Pfam
  PF01138 (RNase_PH)
  
  50 - 180
  
  Pfam
  PF01138 (RNase_PH)
IPR015847

Exoribonuclease, phosphorolytic domain 2
1. PF03725 (RNase_PH_C)
  
  183 - 246
  
  Pfam
  PF03725 (RNase_PH_C)
IPR015848

Polyribonucleotide nucleotidyltransferase, RNA-binding domain
1. PF03726 (PNPase)
  
  279 - 365
  
  Pfam
  PF03726 (PNPase)
IPR004088

K Homology domain, type 1
1. PF00013 (KH_1)
  
  600 - 645
  
  Pfam
  PF00013 (KH_1)
IPR003029

S1 domain
1. PS50126 (S1)
  
  666 - 733
  
  PROSITE profiles
  PS50126 (S1)
2. PF00575 (S1)
  
  664 - 732
  
  Pfam
  PF00575 (S1)

no IPR

Unintegrated signatures

G3DSA:2.40.50...

666 - 740

GENE3D
G3DSA:2.40.50.140 (G3DSA:2.40.50.140)
PS50084 (KH_TYPE_1)

597 - 656

PROSITE profiles
PS50084 (KH_TYPE_1)
PTHR11252:SF0 (POLY...)

39 - 736

PANTHER
PTHR11252:SF0 (POLYRIBONUCLEOTIDE NUCLEOTIDYLTRANSFERASE 1, MITOCHONDRIAL)
cd02393 (PNPase_KH)

597 - 657

CDD
cd02393 (PNPase_KH)
cd04472 (S1_PNPase)

666 - 732

CDD
cd04472 (S1_PNPase)
cd11363 (RNase_PH_P...)

41 - 269

CDD
cd11363 (RNase_PH_PNPase_1)
cd11364 (RNase_PH_P...)

368 - 589

CDD
cd11364 (RNase_PH_PNPase_2)

Residue annotation

RNase E interface ...

42T

RNase E interface
42T, 44E, 53K, 55S, 58K, 68M, 70Q, 72G, 75V
CDD
cd11363 (RNase_PH_PNPase_1)

44E

RNase E interface
42T, 44E, 53K, 55S, 58K, 68M, 70Q, 72G, 75V
CDD
cd11363 (RNase_PH_PNPase_1)

53K

RNase E interface
42T, 44E, 53K, 55S, 58K, 68M, 70Q, 72G, 75V
CDD
cd11363 (RNase_PH_PNPase_1)

55S

RNase E interface
42T, 44E, 53K, 55S, 58K, 68M, 70Q, 72G, 75V
CDD
cd11363 (RNase_PH_PNPase_1)

58K

RNase E interface
42T, 44E, 53K, 55S, 58K, 68M, 70Q, 72G, 75V
CDD
cd11363 (RNase_PH_PNPase_1)

68M

RNase E interface
42T, 44E, 53K, 55S, 58K, 68M, 70Q, 72G, 75V
CDD
cd11363 (RNase_PH_PNPase_1)

70Q

RNase E interface
42T, 44E, 53K, 55S, 58K, 68M, 70Q, 72G, 75V
CDD
cd11363 (RNase_PH_PNPase_1)

72G

RNase E interface
42T, 44E, 53K, 55S, 58K, 68M, 70Q, 72G, 75V
CDD
cd11363 (RNase_PH_PNPase_1)

75V

RNase E interface
42T, 44E, 53K, 55S, 58K, 68M, 70Q, 72G, 75V
CDD
cd11363 (RNase_PH_PNPase_1)
trimer interface c...

58K

trimer interface
58K, 59I, 60A, 61R, 62Q, 63S, 68M, 77L, 79T, 81N, 83S, 98D, 100I, 102K, 103F, 104Y, 105A, 107G, 108K, 109F, 110P, 113F, 114N, 115K, 116R, 117E, 121S, 146D, 148H, 150V, 154F, 155S, 156F, 157D, 158E
CDD
cd11363 (RNase_PH_PNPase_1)

59I

trimer interface
58K, 59I, 60A, 61R, 62Q, 63S, 68M, 77L, 79T, 81N, 83S, 98D, 100I, 102K, 103F, 104Y, 105A, 107G, 108K, 109F, 110P, 113F, 114N, 115K, 116R, 117E, 121S, 146D, 148H, 150V, 154F, 155S, 156F, 157D, 158E
CDD
cd11363 (RNase_PH_PNPase_1)

60A

trimer interface
58K, 59I, 60A, 61R, 62Q, 63S, 68M, 77L, 79T, 81N, 83S, 98D, 100I, 102K, 103F, 104Y, 105A, 107G, 108K, 109F, 110P, 113F, 114N, 115K, 116R, 117E, 121S, 146D, 148H, 150V, 154F, 155S, 156F, 157D, 158E
CDD
cd11363 (RNase_PH_PNPase_1)

61R

trimer interface
58K, 59I, 60A, 61R, 62Q, 63S, 68M, 77L, 79T, 81N, 83S, 98D, 100I, 102K, 103F, 104Y, 105A, 107G, 108K, 109F, 110P, 113F, 114N, 115K, 116R, 117E, 121S, 146D, 148H, 150V, 154F, 155S, 156F, 157D, 158E
CDD
cd11363 (RNase_PH_PNPase_1)

62Q

trimer interface
58K, 59I, 60A, 61R, 62Q, 63S, 68M, 77L, 79T, 81N, 83S, 98D, 100I, 102K, 103F, 104Y, 105A, 107G, 108K, 109F, 110P, 113F, 114N, 115K, 116R, 117E, 121S, 146D, 148H, 150V, 154F, 155S, 156F, 157D, 158E
CDD
cd11363 (RNase_PH_PNPase_1)

63S

trimer interface
58K, 59I, 60A, 61R, 62Q, 63S, 68M, 77L, 79T, 81N, 83S, 98D, 100I, 102K, 103F, 104Y, 105A, 107G, 108K, 109F, 110P, 113F, 114N, 115K, 116R, 117E, 121S, 146D, 148H, 150V, 154F, 155S, 156F, 157D, 158E
CDD
cd11363 (RNase_PH_PNPase_1)

68M

trimer interface
58K, 59I, 60A, 61R, 62Q, 63S, 68M, 77L, 79T, 81N, 83S, 98D, 100I, 102K, 103F, 104Y, 105A, 107G, 108K, 109F, 110P, 113F, 114N, 115K, 116R, 117E, 121S, 146D, 148H, 150V, 154F, 155S, 156F, 157D, 158E
CDD
cd11363 (RNase_PH_PNPase_1)

77L

trimer interface
58K, 59I, 60A, 61R, 62Q, 63S, 68M, 77L, 79T, 81N, 83S, 98D, 100I, 102K, 103F, 104Y, 105A, 107G, 108K, 109F, 110P, 113F, 114N, 115K, 116R, 117E, 121S, 146D, 148H, 150V, 154F, 155S, 156F, 157D, 158E
CDD
cd11363 (RNase_PH_PNPase_1)

79T

trimer interface
58K, 59I, 60A, 61R, 62Q, 63S, 68M, 77L, 79T, 81N, 83S, 98D, 100I, 102K, 103F, 104Y, 105A, 107G, 108K, 109F, 110P, 113F, 114N, 115K, 116R, 117E, 121S, 146D, 148H, 150V, 154F, 155S, 156F, 157D, 158E
CDD
cd11363 (RNase_PH_PNPase_1)

81N

trimer interface
58K, 59I, 60A, 61R, 62Q, 63S, 68M, 77L, 79T, 81N, 83S, 98D, 100I, 102K, 103F, 104Y, 105A, 107G, 108K, 109F, 110P, 113F, 114N, 115K, 116R, 117E, 121S, 146D, 148H, 150V, 154F, 155S, 156F, 157D, 158E
CDD
cd11363 (RNase_PH_PNPase_1)

83S

trimer interface
58K, 59I, 60A, 61R, 62Q, 63S, 68M, 77L, 79T, 81N, 83S, 98D, 100I, 102K, 103F, 104Y, 105A, 107G, 108K, 109F, 110P, 113F, 114N, 115K, 116R, 117E, 121S, 146D, 148H, 150V, 154F, 155S, 156F, 157D, 158E
CDD
cd11363 (RNase_PH_PNPase_1)

98D

trimer interface
58K, 59I, 60A, 61R, 62Q, 63S, 68M, 77L, 79T, 81N, 83S, 98D, 100I, 102K, 103F, 104Y, 105A, 107G, 108K, 109F, 110P, 113F, 114N, 115K, 116R, 117E, 121S, 146D, 148H, 150V, 154F, 155S, 156F, 157D, 158E
CDD
cd11363 (RNase_PH_PNPase_1)

100I

trimer interface
58K, 59I, 60A, 61R, 62Q, 63S, 68M, 77L, 79T, 81N, 83S, 98D, 100I, 102K, 103F, 104Y, 105A, 107G, 108K, 109F, 110P, 113F, 114N, 115K, 116R, 117E, 121S, 146D, 148H, 150V, 154F, 155S, 156F, 157D, 158E
CDD
cd11363 (RNase_PH_PNPase_1)

102K

trimer interface
58K, 59I, 60A, 61R, 62Q, 63S, 68M, 77L, 79T, 81N, 83S, 98D, 100I, 102K, 103F, 104Y, 105A, 107G, 108K, 109F, 110P, 113F, 114N, 115K, 116R, 117E, 121S, 146D, 148H, 150V, 154F, 155S, 156F, 157D, 158E
CDD
cd11363 (RNase_PH_PNPase_1)

103F

trimer interface
58K, 59I, 60A, 61R, 62Q, 63S, 68M, 77L, 79T, 81N, 83S, 98D, 100I, 102K, 103F, 104Y, 105A, 107G, 108K, 109F, 110P, 113F, 114N, 115K, 116R, 117E, 121S, 146D, 148H, 150V, 154F, 155S, 156F, 157D, 158E
CDD
cd11363 (RNase_PH_PNPase_1)

104Y

trimer interface
58K, 59I, 60A, 61R, 62Q, 63S, 68M, 77L, 79T, 81N, 83S, 98D, 100I, 102K, 103F, 104Y, 105A, 107G, 108K, 109F, 110P, 113F, 114N, 115K, 116R, 117E, 121S, 146D, 148H, 150V, 154F, 155S, 156F, 157D, 158E
CDD
cd11363 (RNase_PH_PNPase_1)

105A

trimer interface
58K, 59I, 60A, 61R, 62Q, 63S, 68M, 77L, 79T, 81N, 83S, 98D, 100I, 102K, 103F, 104Y, 105A, 107G, 108K, 109F, 110P, 113F, 114N, 115K, 116R, 117E, 121S, 146D, 148H, 150V, 154F, 155S, 156F, 157D, 158E
CDD
cd11363 (RNase_PH_PNPase_1)

107G

trimer interface
58K, 59I, 60A, 61R, 62Q, 63S, 68M, 77L, 79T, 81N, 83S, 98D, 100I, 102K, 103F, 104Y, 105A, 107G, 108K, 109F, 110P, 113F, 114N, 115K, 116R, 117E, 121S, 146D, 148H, 150V, 154F, 155S, 156F, 157D, 158E
CDD
cd11363 (RNase_PH_PNPase_1)

108K

trimer interface
58K, 59I, 60A, 61R, 62Q, 63S, 68M, 77L, 79T, 81N, 83S, 98D, 100I, 102K, 103F, 104Y, 105A, 107G, 108K, 109F, 110P, 113F, 114N, 115K, 116R, 117E, 121S, 146D, 148H, 150V, 154F, 155S, 156F, 157D, 158E
CDD
cd11363 (RNase_PH_PNPase_1)

109F

trimer interface
58K, 59I, 60A, 61R, 62Q, 63S, 68M, 77L, 79T, 81N, 83S, 98D, 100I, 102K, 103F, 104Y, 105A, 107G, 108K, 109F, 110P, 113F, 114N, 115K, 116R, 117E, 121S, 146D, 148H, 150V, 154F, 155S, 156F, 157D, 158E
CDD
cd11363 (RNase_PH_PNPase_1)

110P

trimer interface
58K, 59I, 60A, 61R, 62Q, 63S, 68M, 77L, 79T, 81N, 83S, 98D, 100I, 102K, 103F, 104Y, 105A, 107G, 108K, 109F, 110P, 113F, 114N, 115K, 116R, 117E, 121S, 146D, 148H, 150V, 154F, 155S, 156F, 157D, 158E
CDD
cd11363 (RNase_PH_PNPase_1)

113F

trimer interface
58K, 59I, 60A, 61R, 62Q, 63S, 68M, 77L, 79T, 81N, 83S, 98D, 100I, 102K, 103F, 104Y, 105A, 107G, 108K, 109F, 110P, 113F, 114N, 115K, 116R, 117E, 121S, 146D, 148H, 150V, 154F, 155S, 156F, 157D, 158E
CDD
cd11363 (RNase_PH_PNPase_1)

114N

trimer interface
58K, 59I, 60A, 61R, 62Q, 63S, 68M, 77L, 79T, 81N, 83S, 98D, 100I, 102K, 103F, 104Y, 105A, 107G, 108K, 109F, 110P, 113F, 114N, 115K, 116R, 117E, 121S, 146D, 148H, 150V, 154F, 155S, 156F, 157D, 158E
CDD
cd11363 (RNase_PH_PNPase_1)

115K

trimer interface
58K, 59I, 60A, 61R, 62Q, 63S, 68M, 77L, 79T, 81N, 83S, 98D, 100I, 102K, 103F, 104Y, 105A, 107G, 108K, 109F, 110P, 113F, 114N, 115K, 116R, 117E, 121S, 146D, 148H, 150V, 154F, 155S, 156F, 157D, 158E
CDD
cd11363 (RNase_PH_PNPase_1)

116R

trimer interface
58K, 59I, 60A, 61R, 62Q, 63S, 68M, 77L, 79T, 81N, 83S, 98D, 100I, 102K, 103F, 104Y, 105A, 107G, 108K, 109F, 110P, 113F, 114N, 115K, 116R, 117E, 121S, 146D, 148H, 150V, 154F, 155S, 156F, 157D, 158E
CDD
cd11363 (RNase_PH_PNPase_1)

117E

trimer interface
58K, 59I, 60A, 61R, 62Q, 63S, 68M, 77L, 79T, 81N, 83S, 98D, 100I, 102K, 103F, 104Y, 105A, 107G, 108K, 109F, 110P, 113F, 114N, 115K, 116R, 117E, 121S, 146D, 148H, 150V, 154F, 155S, 156F, 157D, 158E
CDD
cd11363 (RNase_PH_PNPase_1)

121S

trimer interface
58K, 59I, 60A, 61R, 62Q, 63S, 68M, 77L, 79T, 81N, 83S, 98D, 100I, 102K, 103F, 104Y, 105A, 107G, 108K, 109F, 110P, 113F, 114N, 115K, 116R, 117E, 121S, 146D, 148H, 150V, 154F, 155S, 156F, 157D, 158E
CDD
cd11363 (RNase_PH_PNPase_1)

146D

trimer interface
58K, 59I, 60A, 61R, 62Q, 63S, 68M, 77L, 79T, 81N, 83S, 98D, 100I, 102K, 103F, 104Y, 105A, 107G, 108K, 109F, 110P, 113F, 114N, 115K, 116R, 117E, 121S, 146D, 148H, 150V, 154F, 155S, 156F, 157D, 158E
CDD
cd11363 (RNase_PH_PNPase_1)

148H

trimer interface
58K, 59I, 60A, 61R, 62Q, 63S, 68M, 77L, 79T, 81N, 83S, 98D, 100I, 102K, 103F, 104Y, 105A, 107G, 108K, 109F, 110P, 113F, 114N, 115K, 116R, 117E, 121S, 146D, 148H, 150V, 154F, 155S, 156F, 157D, 158E
CDD
cd11363 (RNase_PH_PNPase_1)

150V

trimer interface
58K, 59I, 60A, 61R, 62Q, 63S, 68M, 77L, 79T, 81N, 83S, 98D, 100I, 102K, 103F, 104Y, 105A, 107G, 108K, 109F, 110P, 113F, 114N, 115K, 116R, 117E, 121S, 146D, 148H, 150V, 154F, 155S, 156F, 157D, 158E
CDD
cd11363 (RNase_PH_PNPase_1)

154F

trimer interface
58K, 59I, 60A, 61R, 62Q, 63S, 68M, 77L, 79T, 81N, 83S, 98D, 100I, 102K, 103F, 104Y, 105A, 107G, 108K, 109F, 110P, 113F, 114N, 115K, 116R, 117E, 121S, 146D, 148H, 150V, 154F, 155S, 156F, 157D, 158E
CDD
cd11363 (RNase_PH_PNPase_1)

155S

trimer interface
58K, 59I, 60A, 61R, 62Q, 63S, 68M, 77L, 79T, 81N, 83S, 98D, 100I, 102K, 103F, 104Y, 105A, 107G, 108K, 109F, 110P, 113F, 114N, 115K, 116R, 117E, 121S, 146D, 148H, 150V, 154F, 155S, 156F, 157D, 158E
CDD
cd11363 (RNase_PH_PNPase_1)

156F

trimer interface
58K, 59I, 60A, 61R, 62Q, 63S, 68M, 77L, 79T, 81N, 83S, 98D, 100I, 102K, 103F, 104Y, 105A, 107G, 108K, 109F, 110P, 113F, 114N, 115K, 116R, 117E, 121S, 146D, 148H, 150V, 154F, 155S, 156F, 157D, 158E
CDD
cd11363 (RNase_PH_PNPase_1)

157D

trimer interface
58K, 59I, 60A, 61R, 62Q, 63S, 68M, 77L, 79T, 81N, 83S, 98D, 100I, 102K, 103F, 104Y, 105A, 107G, 108K, 109F, 110P, 113F, 114N, 115K, 116R, 117E, 121S, 146D, 148H, 150V, 154F, 155S, 156F, 157D, 158E
CDD
cd11363 (RNase_PH_PNPase_1)

158E

trimer interface
58K, 59I, 60A, 61R, 62Q, 63S, 68M, 77L, 79T, 81N, 83S, 98D, 100I, 102K, 103F, 104Y, 105A, 107G, 108K, 109F, 110P, 113F, 114N, 115K, 116R, 117E, 121S, 146D, 148H, 150V, 154F, 155S, 156F, 157D, 158E
CDD
cd11363 (RNase_PH_PNPase_1)
RNase E interface ...

368E

RNase E interface
368E, 369I, 370R, 371P, 372L, 373D, 374A, 375Q, 376I, 377N, 380P, 573V, 577Q, 581V, 585A, 586I
CDD
cd11364 (RNase_PH_PNPase_2)

369I

RNase E interface
368E, 369I, 370R, 371P, 372L, 373D, 374A, 375Q, 376I, 377N, 380P, 573V, 577Q, 581V, 585A, 586I
CDD
cd11364 (RNase_PH_PNPase_2)

370R

RNase E interface
368E, 369I, 370R, 371P, 372L, 373D, 374A, 375Q, 376I, 377N, 380P, 573V, 577Q, 581V, 585A, 586I
CDD
cd11364 (RNase_PH_PNPase_2)

371P

RNase E interface
368E, 369I, 370R, 371P, 372L, 373D, 374A, 375Q, 376I, 377N, 380P, 573V, 577Q, 581V, 585A, 586I
CDD
cd11364 (RNase_PH_PNPase_2)

372L

RNase E interface
368E, 369I, 370R, 371P, 372L, 373D, 374A, 375Q, 376I, 377N, 380P, 573V, 577Q, 581V, 585A, 586I
CDD
cd11364 (RNase_PH_PNPase_2)

373D

RNase E interface
368E, 369I, 370R, 371P, 372L, 373D, 374A, 375Q, 376I, 377N, 380P, 573V, 577Q, 581V, 585A, 586I
CDD
cd11364 (RNase_PH_PNPase_2)

374A

RNase E interface
368E, 369I, 370R, 371P, 372L, 373D, 374A, 375Q, 376I, 377N, 380P, 573V, 577Q, 581V, 585A, 586I
CDD
cd11364 (RNase_PH_PNPase_2)

375Q

RNase E interface
368E, 369I, 370R, 371P, 372L, 373D, 374A, 375Q, 376I, 377N, 380P, 573V, 577Q, 581V, 585A, 586I
CDD
cd11364 (RNase_PH_PNPase_2)

376I

RNase E interface
368E, 369I, 370R, 371P, 372L, 373D, 374A, 375Q, 376I, 377N, 380P, 573V, 577Q, 581V, 585A, 586I
CDD
cd11364 (RNase_PH_PNPase_2)

377N

RNase E interface
368E, 369I, 370R, 371P, 372L, 373D, 374A, 375Q, 376I, 377N, 380P, 573V, 577Q, 581V, 585A, 586I
CDD
cd11364 (RNase_PH_PNPase_2)

380P

RNase E interface
368E, 369I, 370R, 371P, 372L, 373D, 374A, 375Q, 376I, 377N, 380P, 573V, 577Q, 581V, 585A, 586I
CDD
cd11364 (RNase_PH_PNPase_2)

573V

RNase E interface
368E, 369I, 370R, 371P, 372L, 373D, 374A, 375Q, 376I, 377N, 380P, 573V, 577Q, 581V, 585A, 586I
CDD
cd11364 (RNase_PH_PNPase_2)

577Q

RNase E interface
368E, 369I, 370R, 371P, 372L, 373D, 374A, 375Q, 376I, 377N, 380P, 573V, 577Q, 581V, 585A, 586I
CDD
cd11364 (RNase_PH_PNPase_2)

581V

RNase E interface
368E, 369I, 370R, 371P, 372L, 373D, 374A, 375Q, 376I, 377N, 380P, 573V, 577Q, 581V, 585A, 586I
CDD
cd11364 (RNase_PH_PNPase_2)

585A

RNase E interface
368E, 369I, 370R, 371P, 372L, 373D, 374A, 375Q, 376I, 377N, 380P, 573V, 577Q, 581V, 585A, 586I
CDD
cd11364 (RNase_PH_PNPase_2)

586I

RNase E interface
368E, 369I, 370R, 371P, 372L, 373D, 374A, 375Q, 376I, 377N, 380P, 573V, 577Q, 581V, 585A, 586I
CDD
cd11364 (RNase_PH_PNPase_2)
trimer interface c...

373D

trimer interface
373D, 375Q, 379L, 380P, 381I, 382P, 383H, 391G, 392E, 396L, 398T, 400T, 401L, 402G, 406D, 407E, 408Q, 424H, 426N, 429P, 430Y, 431S, 432V, 434E, 435T, 436G, 439G, 441P, 471R, 473V, 475D, 477T, 478E, 479S
CDD
cd11364 (RNase_PH_PNPase_2)

375Q

trimer interface
373D, 375Q, 379L, 380P, 381I, 382P, 383H, 391G, 392E, 396L, 398T, 400T, 401L, 402G, 406D, 407E, 408Q, 424H, 426N, 429P, 430Y, 431S, 432V, 434E, 435T, 436G, 439G, 441P, 471R, 473V, 475D, 477T, 478E, 479S
CDD
cd11364 (RNase_PH_PNPase_2)

379L

trimer interface
373D, 375Q, 379L, 380P, 381I, 382P, 383H, 391G, 392E, 396L, 398T, 400T, 401L, 402G, 406D, 407E, 408Q, 424H, 426N, 429P, 430Y, 431S, 432V, 434E, 435T, 436G, 439G, 441P, 471R, 473V, 475D, 477T, 478E, 479S
CDD
cd11364 (RNase_PH_PNPase_2)

380P

trimer interface
373D, 375Q, 379L, 380P, 381I, 382P, 383H, 391G, 392E, 396L, 398T, 400T, 401L, 402G, 406D, 407E, 408Q, 424H, 426N, 429P, 430Y, 431S, 432V, 434E, 435T, 436G, 439G, 441P, 471R, 473V, 475D, 477T, 478E, 479S
CDD
cd11364 (RNase_PH_PNPase_2)

381I

trimer interface
373D, 375Q, 379L, 380P, 381I, 382P, 383H, 391G, 392E, 396L, 398T, 400T, 401L, 402G, 406D, 407E, 408Q, 424H, 426N, 429P, 430Y, 431S, 432V, 434E, 435T, 436G, 439G, 441P, 471R, 473V, 475D, 477T, 478E, 479S
CDD
cd11364 (RNase_PH_PNPase_2)

382P

trimer interface
373D, 375Q, 379L, 380P, 381I, 382P, 383H, 391G, 392E, 396L, 398T, 400T, 401L, 402G, 406D, 407E, 408Q, 424H, 426N, 429P, 430Y, 431S, 432V, 434E, 435T, 436G, 439G, 441P, 471R, 473V, 475D, 477T, 478E, 479S
CDD
cd11364 (RNase_PH_PNPase_2)

383H

trimer interface
373D, 375Q, 379L, 380P, 381I, 382P, 383H, 391G, 392E, 396L, 398T, 400T, 401L, 402G, 406D, 407E, 408Q, 424H, 426N, 429P, 430Y, 431S, 432V, 434E, 435T, 436G, 439G, 441P, 471R, 473V, 475D, 477T, 478E, 479S
CDD
cd11364 (RNase_PH_PNPase_2)

391G

trimer interface
373D, 375Q, 379L, 380P, 381I, 382P, 383H, 391G, 392E, 396L, 398T, 400T, 401L, 402G, 406D, 407E, 408Q, 424H, 426N, 429P, 430Y, 431S, 432V, 434E, 435T, 436G, 439G, 441P, 471R, 473V, 475D, 477T, 478E, 479S
CDD
cd11364 (RNase_PH_PNPase_2)

392E

trimer interface
373D, 375Q, 379L, 380P, 381I, 382P, 383H, 391G, 392E, 396L, 398T, 400T, 401L, 402G, 406D, 407E, 408Q, 424H, 426N, 429P, 430Y, 431S, 432V, 434E, 435T, 436G, 439G, 441P, 471R, 473V, 475D, 477T, 478E, 479S
CDD
cd11364 (RNase_PH_PNPase_2)

396L

trimer interface
373D, 375Q, 379L, 380P, 381I, 382P, 383H, 391G, 392E, 396L, 398T, 400T, 401L, 402G, 406D, 407E, 408Q, 424H, 426N, 429P, 430Y, 431S, 432V, 434E, 435T, 436G, 439G, 441P, 471R, 473V, 475D, 477T, 478E, 479S
CDD
cd11364 (RNase_PH_PNPase_2)

398T

trimer interface
373D, 375Q, 379L, 380P, 381I, 382P, 383H, 391G, 392E, 396L, 398T, 400T, 401L, 402G, 406D, 407E, 408Q, 424H, 426N, 429P, 430Y, 431S, 432V, 434E, 435T, 436G, 439G, 441P, 471R, 473V, 475D, 477T, 478E, 479S
CDD
cd11364 (RNase_PH_PNPase_2)

400T

trimer interface
373D, 375Q, 379L, 380P, 381I, 382P, 383H, 391G, 392E, 396L, 398T, 400T, 401L, 402G, 406D, 407E, 408Q, 424H, 426N, 429P, 430Y, 431S, 432V, 434E, 435T, 436G, 439G, 441P, 471R, 473V, 475D, 477T, 478E, 479S
CDD
cd11364 (RNase_PH_PNPase_2)

401L

trimer interface
373D, 375Q, 379L, 380P, 381I, 382P, 383H, 391G, 392E, 396L, 398T, 400T, 401L, 402G, 406D, 407E, 408Q, 424H, 426N, 429P, 430Y, 431S, 432V, 434E, 435T, 436G, 439G, 441P, 471R, 473V, 475D, 477T, 478E, 479S
CDD
cd11364 (RNase_PH_PNPase_2)

402G

trimer interface
373D, 375Q, 379L, 380P, 381I, 382P, 383H, 391G, 392E, 396L, 398T, 400T, 401L, 402G, 406D, 407E, 408Q, 424H, 426N, 429P, 430Y, 431S, 432V, 434E, 435T, 436G, 439G, 441P, 471R, 473V, 475D, 477T, 478E, 479S
CDD
cd11364 (RNase_PH_PNPase_2)

406D

trimer interface
373D, 375Q, 379L, 380P, 381I, 382P, 383H, 391G, 392E, 396L, 398T, 400T, 401L, 402G, 406D, 407E, 408Q, 424H, 426N, 429P, 430Y, 431S, 432V, 434E, 435T, 436G, 439G, 441P, 471R, 473V, 475D, 477T, 478E, 479S
CDD
cd11364 (RNase_PH_PNPase_2)

407E

trimer interface
373D, 375Q, 379L, 380P, 381I, 382P, 383H, 391G, 392E, 396L, 398T, 400T, 401L, 402G, 406D, 407E, 408Q, 424H, 426N, 429P, 430Y, 431S, 432V, 434E, 435T, 436G, 439G, 441P, 471R, 473V, 475D, 477T, 478E, 479S
CDD
cd11364 (RNase_PH_PNPase_2)

408Q

trimer interface
373D, 375Q, 379L, 380P, 381I, 382P, 383H, 391G, 392E, 396L, 398T, 400T, 401L, 402G, 406D, 407E, 408Q, 424H, 426N, 429P, 430Y, 431S, 432V, 434E, 435T, 436G, 439G, 441P, 471R, 473V, 475D, 477T, 478E, 479S
CDD
cd11364 (RNase_PH_PNPase_2)

424H

trimer interface
373D, 375Q, 379L, 380P, 381I, 382P, 383H, 391G, 392E, 396L, 398T, 400T, 401L, 402G, 406D, 407E, 408Q, 424H, 426N, 429P, 430Y, 431S, 432V, 434E, 435T, 436G, 439G, 441P, 471R, 473V, 475D, 477T, 478E, 479S
CDD
cd11364 (RNase_PH_PNPase_2)

426N

trimer interface
373D, 375Q, 379L, 380P, 381I, 382P, 383H, 391G, 392E, 396L, 398T, 400T, 401L, 402G, 406D, 407E, 408Q, 424H, 426N, 429P, 430Y, 431S, 432V, 434E, 435T, 436G, 439G, 441P, 471R, 473V, 475D, 477T, 478E, 479S
CDD
cd11364 (RNase_PH_PNPase_2)

429P

trimer interface
373D, 375Q, 379L, 380P, 381I, 382P, 383H, 391G, 392E, 396L, 398T, 400T, 401L, 402G, 406D, 407E, 408Q, 424H, 426N, 429P, 430Y, 431S, 432V, 434E, 435T, 436G, 439G, 441P, 471R, 473V, 475D, 477T, 478E, 479S
CDD
cd11364 (RNase_PH_PNPase_2)

430Y

trimer interface
373D, 375Q, 379L, 380P, 381I, 382P, 383H, 391G, 392E, 396L, 398T, 400T, 401L, 402G, 406D, 407E, 408Q, 424H, 426N, 429P, 430Y, 431S, 432V, 434E, 435T, 436G, 439G, 441P, 471R, 473V, 475D, 477T, 478E, 479S
CDD
cd11364 (RNase_PH_PNPase_2)

431S

trimer interface
373D, 375Q, 379L, 380P, 381I, 382P, 383H, 391G, 392E, 396L, 398T, 400T, 401L, 402G, 406D, 407E, 408Q, 424H, 426N, 429P, 430Y, 431S, 432V, 434E, 435T, 436G, 439G, 441P, 471R, 473V, 475D, 477T, 478E, 479S
CDD
cd11364 (RNase_PH_PNPase_2)

432V

trimer interface
373D, 375Q, 379L, 380P, 381I, 382P, 383H, 391G, 392E, 396L, 398T, 400T, 401L, 402G, 406D, 407E, 408Q, 424H, 426N, 429P, 430Y, 431S, 432V, 434E, 435T, 436G, 439G, 441P, 471R, 473V, 475D, 477T, 478E, 479S
CDD
cd11364 (RNase_PH_PNPase_2)

434E

trimer interface
373D, 375Q, 379L, 380P, 381I, 382P, 383H, 391G, 392E, 396L, 398T, 400T, 401L, 402G, 406D, 407E, 408Q, 424H, 426N, 429P, 430Y, 431S, 432V, 434E, 435T, 436G, 439G, 441P, 471R, 473V, 475D, 477T, 478E, 479S
CDD
cd11364 (RNase_PH_PNPase_2)

435T

trimer interface
373D, 375Q, 379L, 380P, 381I, 382P, 383H, 391G, 392E, 396L, 398T, 400T, 401L, 402G, 406D, 407E, 408Q, 424H, 426N, 429P, 430Y, 431S, 432V, 434E, 435T, 436G, 439G, 441P, 471R, 473V, 475D, 477T, 478E, 479S
CDD
cd11364 (RNase_PH_PNPase_2)

436G

trimer interface
373D, 375Q, 379L, 380P, 381I, 382P, 383H, 391G, 392E, 396L, 398T, 400T, 401L, 402G, 406D, 407E, 408Q, 424H, 426N, 429P, 430Y, 431S, 432V, 434E, 435T, 436G, 439G, 441P, 471R, 473V, 475D, 477T, 478E, 479S
CDD
cd11364 (RNase_PH_PNPase_2)

439G

trimer interface
373D, 375Q, 379L, 380P, 381I, 382P, 383H, 391G, 392E, 396L, 398T, 400T, 401L, 402G, 406D, 407E, 408Q, 424H, 426N, 429P, 430Y, 431S, 432V, 434E, 435T, 436G, 439G, 441P, 471R, 473V, 475D, 477T, 478E, 479S
CDD
cd11364 (RNase_PH_PNPase_2)

441P

trimer interface
373D, 375Q, 379L, 380P, 381I, 382P, 383H, 391G, 392E, 396L, 398T, 400T, 401L, 402G, 406D, 407E, 408Q, 424H, 426N, 429P, 430Y, 431S, 432V, 434E, 435T, 436G, 439G, 441P, 471R, 473V, 475D, 477T, 478E, 479S
CDD
cd11364 (RNase_PH_PNPase_2)

471R

trimer interface
373D, 375Q, 379L, 380P, 381I, 382P, 383H, 391G, 392E, 396L, 398T, 400T, 401L, 402G, 406D, 407E, 408Q, 424H, 426N, 429P, 430Y, 431S, 432V, 434E, 435T, 436G, 439G, 441P, 471R, 473V, 475D, 477T, 478E, 479S
CDD
cd11364 (RNase_PH_PNPase_2)

473V

trimer interface
373D, 375Q, 379L, 380P, 381I, 382P, 383H, 391G, 392E, 396L, 398T, 400T, 401L, 402G, 406D, 407E, 408Q, 424H, 426N, 429P, 430Y, 431S, 432V, 434E, 435T, 436G, 439G, 441P, 471R, 473V, 475D, 477T, 478E, 479S
CDD
cd11364 (RNase_PH_PNPase_2)

475D

trimer interface
373D, 375Q, 379L, 380P, 381I, 382P, 383H, 391G, 392E, 396L, 398T, 400T, 401L, 402G, 406D, 407E, 408Q, 424H, 426N, 429P, 430Y, 431S, 432V, 434E, 435T, 436G, 439G, 441P, 471R, 473V, 475D, 477T, 478E, 479S
CDD
cd11364 (RNase_PH_PNPase_2)

477T

trimer interface
373D, 375Q, 379L, 380P, 381I, 382P, 383H, 391G, 392E, 396L, 398T, 400T, 401L, 402G, 406D, 407E, 408Q, 424H, 426N, 429P, 430Y, 431S, 432V, 434E, 435T, 436G, 439G, 441P, 471R, 473V, 475D, 477T, 478E, 479S
CDD
cd11364 (RNase_PH_PNPase_2)

478E

trimer interface
373D, 375Q, 379L, 380P, 381I, 382P, 383H, 391G, 392E, 396L, 398T, 400T, 401L, 402G, 406D, 407E, 408Q, 424H, 426N, 429P, 430Y, 431S, 432V, 434E, 435T, 436G, 439G, 441P, 471R, 473V, 475D, 477T, 478E, 479S
CDD
cd11364 (RNase_PH_PNPase_2)

479S

trimer interface
373D, 375Q, 379L, 380P, 381I, 382P, 383H, 391G, 392E, 396L, 398T, 400T, 401L, 402G, 406D, 407E, 408Q, 424H, 426N, 429P, 430Y, 431S, 432V, 434E, 435T, 436G, 439G, 441P, 471R, 473V, 475D, 477T, 478E, 479S
CDD
cd11364 (RNase_PH_PNPase_2)
active site cd11364

425Y

active site
425Y, 427F, 444R, 448H, 482S, 483S, 484S, 531D, 537D, 539K, 551Q, 553D
CDD
cd11364 (RNase_PH_PNPase_2)

427F

active site
425Y, 427F, 444R, 448H, 482S, 483S, 484S, 531D, 537D, 539K, 551Q, 553D
CDD
cd11364 (RNase_PH_PNPase_2)

444R

active site
425Y, 427F, 444R, 448H, 482S, 483S, 484S, 531D, 537D, 539K, 551Q, 553D
CDD
cd11364 (RNase_PH_PNPase_2)

448H

active site
425Y, 427F, 444R, 448H, 482S, 483S, 484S, 531D, 537D, 539K, 551Q, 553D
CDD
cd11364 (RNase_PH_PNPase_2)

482S

active site
425Y, 427F, 444R, 448H, 482S, 483S, 484S, 531D, 537D, 539K, 551Q, 553D
CDD
cd11364 (RNase_PH_PNPase_2)

483S

active site
425Y, 427F, 444R, 448H, 482S, 483S, 484S, 531D, 537D, 539K, 551Q, 553D
CDD
cd11364 (RNase_PH_PNPase_2)

484S

active site
425Y, 427F, 444R, 448H, 482S, 483S, 484S, 531D, 537D, 539K, 551Q, 553D
CDD
cd11364 (RNase_PH_PNPase_2)

531D

active site
425Y, 427F, 444R, 448H, 482S, 483S, 484S, 531D, 537D, 539K, 551Q, 553D
CDD
cd11364 (RNase_PH_PNPase_2)

537D

active site
425Y, 427F, 444R, 448H, 482S, 483S, 484S, 531D, 537D, 539K, 551Q, 553D
CDD
cd11364 (RNase_PH_PNPase_2)

539K

active site
425Y, 427F, 444R, 448H, 482S, 483S, 484S, 531D, 537D, 539K, 551Q, 553D
CDD
cd11364 (RNase_PH_PNPase_2)

551Q

active site
425Y, 427F, 444R, 448H, 482S, 483S, 484S, 531D, 537D, 539K, 551Q, 553D
CDD
cd11364 (RNase_PH_PNPase_2)

553D

active site
425Y, 427F, 444R, 448H, 482S, 483S, 484S, 531D, 537D, 539K, 551Q, 553D
CDD
cd11364 (RNase_PH_PNPase_2)
putative nucleic a...

607D

putative nucleic acid binding region
607D, 609I, 610A, 611I, 613I, 614G, 615P, 616A, 617G, 620I, 621K, 624I, 625E, 630T, 631I, 632D, 633I
CDD
cd02393 (PNPase_KH)

609I

putative nucleic acid binding region
607D, 609I, 610A, 611I, 613I, 614G, 615P, 616A, 617G, 620I, 621K, 624I, 625E, 630T, 631I, 632D, 633I
CDD
cd02393 (PNPase_KH)

610A

putative nucleic acid binding region
607D, 609I, 610A, 611I, 613I, 614G, 615P, 616A, 617G, 620I, 621K, 624I, 625E, 630T, 631I, 632D, 633I
CDD
cd02393 (PNPase_KH)

611I

putative nucleic acid binding region
607D, 609I, 610A, 611I, 613I, 614G, 615P, 616A, 617G, 620I, 621K, 624I, 625E, 630T, 631I, 632D, 633I
CDD
cd02393 (PNPase_KH)

613I

putative nucleic acid binding region
607D, 609I, 610A, 611I, 613I, 614G, 615P, 616A, 617G, 620I, 621K, 624I, 625E, 630T, 631I, 632D, 633I
CDD
cd02393 (PNPase_KH)

614G

putative nucleic acid binding region
607D, 609I, 610A, 611I, 613I, 614G, 615P, 616A, 617G, 620I, 621K, 624I, 625E, 630T, 631I, 632D, 633I
CDD
cd02393 (PNPase_KH)

615P

putative nucleic acid binding region
607D, 609I, 610A, 611I, 613I, 614G, 615P, 616A, 617G, 620I, 621K, 624I, 625E, 630T, 631I, 632D, 633I
CDD
cd02393 (PNPase_KH)

616A

putative nucleic acid binding region
607D, 609I, 610A, 611I, 613I, 614G, 615P, 616A, 617G, 620I, 621K, 624I, 625E, 630T, 631I, 632D, 633I
CDD
cd02393 (PNPase_KH)

617G

putative nucleic acid binding region
607D, 609I, 610A, 611I, 613I, 614G, 615P, 616A, 617G, 620I, 621K, 624I, 625E, 630T, 631I, 632D, 633I
CDD
cd02393 (PNPase_KH)

620I

putative nucleic acid binding region
607D, 609I, 610A, 611I, 613I, 614G, 615P, 616A, 617G, 620I, 621K, 624I, 625E, 630T, 631I, 632D, 633I
CDD
cd02393 (PNPase_KH)

621K

putative nucleic acid binding region
607D, 609I, 610A, 611I, 613I, 614G, 615P, 616A, 617G, 620I, 621K, 624I, 625E, 630T, 631I, 632D, 633I
CDD
cd02393 (PNPase_KH)

624I

putative nucleic acid binding region
607D, 609I, 610A, 611I, 613I, 614G, 615P, 616A, 617G, 620I, 621K, 624I, 625E, 630T, 631I, 632D, 633I
CDD
cd02393 (PNPase_KH)

625E

putative nucleic acid binding region
607D, 609I, 610A, 611I, 613I, 614G, 615P, 616A, 617G, 620I, 621K, 624I, 625E, 630T, 631I, 632D, 633I
CDD
cd02393 (PNPase_KH)

630T

putative nucleic acid binding region
607D, 609I, 610A, 611I, 613I, 614G, 615P, 616A, 617G, 620I, 621K, 624I, 625E, 630T, 631I, 632D, 633I
CDD
cd02393 (PNPase_KH)

631I

putative nucleic acid binding region
607D, 609I, 610A, 611I, 613I, 614G, 615P, 616A, 617G, 620I, 621K, 624I, 625E, 630T, 631I, 632D, 633I
CDD
cd02393 (PNPase_KH)

632D

putative nucleic acid binding region
607D, 609I, 610A, 611I, 613I, 614G, 615P, 616A, 617G, 620I, 621K, 624I, 625E, 630T, 631I, 632D, 633I
CDD
cd02393 (PNPase_KH)

633I

putative nucleic acid binding region
607D, 609I, 610A, 611I, 613I, 614G, 615P, 616A, 617G, 620I, 621K, 624I, 625E, 630T, 631I, 632D, 633I
CDD
cd02393 (PNPase_KH)
G-X-X-G motif cd02...

614G

G-X-X-G motif
614G, 615P, 616A, 617G
CDD
cd02393 (PNPase_KH)

615P

G-X-X-G motif
614G, 615P, 616A, 617G
CDD
cd02393 (PNPase_KH)

616A

G-X-X-G motif
614G, 615P, 616A, 617G
CDD
cd02393 (PNPase_KH)

617G

G-X-X-G motif
614G, 615P, 616A, 617G
CDD
cd02393 (PNPase_KH)
RNA binding site c...

674V

RNA binding site
674V, 682F, 692L, 694H
CDD
cd04472 (S1_PNPase)

682F

RNA binding site
674V, 682F, 692L, 694H
CDD
cd04472 (S1_PNPase)

692L

RNA binding site
674V, 682F, 692L, 694H
CDD
cd04472 (S1_PNPase)

694H

RNA binding site
674V, 682F, 692L, 694H
CDD
cd04472 (S1_PNPase)
domain interface c...

713G

domain interface
713G, 714D
CDD
cd04472 (S1_PNPase)

714D

domain interface
713G, 714D
CDD
cd04472 (S1_PNPase)

GO term prediction

Biological Process

GO:0006396 RNA processing
GO:0006402 mRNA catabolic process

Molecular Function

GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0004654 polyribonucleotide nucleotidyltransferase activity

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features

1_1_36S_FusoPortal_Gene_1190

Protein family membership

Homologous superfamilies

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component