1_1_36S_FusoPortal_Gene_1731

Protein

1_1_36S_FusoPortal_Gene_1731

Length

245 amino acids

Protein family membership

DAGK family (IPR000829)

Homologous superfamilies

Homologous superfamily
10 - 109
Diacylglycerol kinase (DAGK) superfamily (IPR036945)
Homologous superfamily
105 - 237
Phosphatidic acid phosphatase type 2/haloperoxidase superfamily (IPR036938)

1 50 100 150 200 245

Domains and repeats

Domain
165 - 243
Phosphatidic acid phosphatase type 2/haloperoxidase (IPR000326)

1 50 100 150 200 245

Detailed signature matches

IPR036945

Diacylglycerol kinase (DAGK) superfamily
1. G3DSA:1.10.38...
  
  10 - 109
  
  GENE3D
  G3DSA:1.10.3830.10 (G3DSA:1.10.3830.10)
IPR036938

Phosphatidic acid phosphatase type 2/haloperoxidase superfamily
1. SSF48317 (Acid phos...)
  
  105 - 237
  
  SUPERFAMILY
  SSF48317 (Acid phosphatase/Vanadium-dependent haloperoxidase)
IPR000829

DAGK family
1. PF01219 (DAGK_prokar)
  
  20 - 120
  
  Pfam
  PF01219 (DAGK_prokar)
IPR000326

Phosphatidic acid phosphatase type 2/haloperoxidase
1. PF01569 (PAP2)
  
  165 - 243
  
  Pfam
  PF01569 (PAP2)

no IPR

Unintegrated signatures

G3DSA:1.20.14...

110 - 243

GENE3D
G3DSA:1.20.144.10 (G3DSA:1.20.144.10)
PTHR34299 (FAMILY N...)

179 - 197

PANTHER
PTHR34299 (FAMILY NOT NAMED)

7 - 124

PANTHER
PTHR34299 (FAMILY NOT NAMED)

145 - 156

PANTHER
PTHR34299 (FAMILY NOT NAMED)
cd03383 (PAP2_diacy...)

136 - 236

CDD
cd03383 (PAP2_diacylglycerolkinase)
cd14266 (UDPK_IM_PA...)

15 - 120

CDD
cd14266 (UDPK_IM_PAP2_like)

Residue annotation

trimer interface c...

19N

trimer interface
19N, 20S, 21A, 22I, 23E, 24G, 25V, 27E, 28T, 56R, 57Y, 58E, 60L, 61A, 64I, 67S, 71L, 72A, 74L, 75F, 77T, 78A, 79I, 81C, 82C, 83V, 85L, 86T, 93L, 94A, 97A, 100V, 103G, 104A, 107L, 108S, 111N, 115I, 118L, 119V
CDD
cd14266 (UDPK_IM_PAP2_like)

20S

trimer interface
19N, 20S, 21A, 22I, 23E, 24G, 25V, 27E, 28T, 56R, 57Y, 58E, 60L, 61A, 64I, 67S, 71L, 72A, 74L, 75F, 77T, 78A, 79I, 81C, 82C, 83V, 85L, 86T, 93L, 94A, 97A, 100V, 103G, 104A, 107L, 108S, 111N, 115I, 118L, 119V
CDD
cd14266 (UDPK_IM_PAP2_like)

21A

trimer interface
19N, 20S, 21A, 22I, 23E, 24G, 25V, 27E, 28T, 56R, 57Y, 58E, 60L, 61A, 64I, 67S, 71L, 72A, 74L, 75F, 77T, 78A, 79I, 81C, 82C, 83V, 85L, 86T, 93L, 94A, 97A, 100V, 103G, 104A, 107L, 108S, 111N, 115I, 118L, 119V
CDD
cd14266 (UDPK_IM_PAP2_like)

22I

trimer interface
19N, 20S, 21A, 22I, 23E, 24G, 25V, 27E, 28T, 56R, 57Y, 58E, 60L, 61A, 64I, 67S, 71L, 72A, 74L, 75F, 77T, 78A, 79I, 81C, 82C, 83V, 85L, 86T, 93L, 94A, 97A, 100V, 103G, 104A, 107L, 108S, 111N, 115I, 118L, 119V
CDD
cd14266 (UDPK_IM_PAP2_like)

23E

trimer interface
19N, 20S, 21A, 22I, 23E, 24G, 25V, 27E, 28T, 56R, 57Y, 58E, 60L, 61A, 64I, 67S, 71L, 72A, 74L, 75F, 77T, 78A, 79I, 81C, 82C, 83V, 85L, 86T, 93L, 94A, 97A, 100V, 103G, 104A, 107L, 108S, 111N, 115I, 118L, 119V
CDD
cd14266 (UDPK_IM_PAP2_like)

24G

trimer interface
19N, 20S, 21A, 22I, 23E, 24G, 25V, 27E, 28T, 56R, 57Y, 58E, 60L, 61A, 64I, 67S, 71L, 72A, 74L, 75F, 77T, 78A, 79I, 81C, 82C, 83V, 85L, 86T, 93L, 94A, 97A, 100V, 103G, 104A, 107L, 108S, 111N, 115I, 118L, 119V
CDD
cd14266 (UDPK_IM_PAP2_like)

25V

trimer interface
19N, 20S, 21A, 22I, 23E, 24G, 25V, 27E, 28T, 56R, 57Y, 58E, 60L, 61A, 64I, 67S, 71L, 72A, 74L, 75F, 77T, 78A, 79I, 81C, 82C, 83V, 85L, 86T, 93L, 94A, 97A, 100V, 103G, 104A, 107L, 108S, 111N, 115I, 118L, 119V
CDD
cd14266 (UDPK_IM_PAP2_like)

27E

trimer interface
19N, 20S, 21A, 22I, 23E, 24G, 25V, 27E, 28T, 56R, 57Y, 58E, 60L, 61A, 64I, 67S, 71L, 72A, 74L, 75F, 77T, 78A, 79I, 81C, 82C, 83V, 85L, 86T, 93L, 94A, 97A, 100V, 103G, 104A, 107L, 108S, 111N, 115I, 118L, 119V
CDD
cd14266 (UDPK_IM_PAP2_like)

28T

trimer interface
19N, 20S, 21A, 22I, 23E, 24G, 25V, 27E, 28T, 56R, 57Y, 58E, 60L, 61A, 64I, 67S, 71L, 72A, 74L, 75F, 77T, 78A, 79I, 81C, 82C, 83V, 85L, 86T, 93L, 94A, 97A, 100V, 103G, 104A, 107L, 108S, 111N, 115I, 118L, 119V
CDD
cd14266 (UDPK_IM_PAP2_like)

56R

trimer interface
19N, 20S, 21A, 22I, 23E, 24G, 25V, 27E, 28T, 56R, 57Y, 58E, 60L, 61A, 64I, 67S, 71L, 72A, 74L, 75F, 77T, 78A, 79I, 81C, 82C, 83V, 85L, 86T, 93L, 94A, 97A, 100V, 103G, 104A, 107L, 108S, 111N, 115I, 118L, 119V
CDD
cd14266 (UDPK_IM_PAP2_like)

57Y

trimer interface
19N, 20S, 21A, 22I, 23E, 24G, 25V, 27E, 28T, 56R, 57Y, 58E, 60L, 61A, 64I, 67S, 71L, 72A, 74L, 75F, 77T, 78A, 79I, 81C, 82C, 83V, 85L, 86T, 93L, 94A, 97A, 100V, 103G, 104A, 107L, 108S, 111N, 115I, 118L, 119V
CDD
cd14266 (UDPK_IM_PAP2_like)

58E

trimer interface
19N, 20S, 21A, 22I, 23E, 24G, 25V, 27E, 28T, 56R, 57Y, 58E, 60L, 61A, 64I, 67S, 71L, 72A, 74L, 75F, 77T, 78A, 79I, 81C, 82C, 83V, 85L, 86T, 93L, 94A, 97A, 100V, 103G, 104A, 107L, 108S, 111N, 115I, 118L, 119V
CDD
cd14266 (UDPK_IM_PAP2_like)

60L

trimer interface
19N, 20S, 21A, 22I, 23E, 24G, 25V, 27E, 28T, 56R, 57Y, 58E, 60L, 61A, 64I, 67S, 71L, 72A, 74L, 75F, 77T, 78A, 79I, 81C, 82C, 83V, 85L, 86T, 93L, 94A, 97A, 100V, 103G, 104A, 107L, 108S, 111N, 115I, 118L, 119V
CDD
cd14266 (UDPK_IM_PAP2_like)

61A

trimer interface
19N, 20S, 21A, 22I, 23E, 24G, 25V, 27E, 28T, 56R, 57Y, 58E, 60L, 61A, 64I, 67S, 71L, 72A, 74L, 75F, 77T, 78A, 79I, 81C, 82C, 83V, 85L, 86T, 93L, 94A, 97A, 100V, 103G, 104A, 107L, 108S, 111N, 115I, 118L, 119V
CDD
cd14266 (UDPK_IM_PAP2_like)

64I

trimer interface
19N, 20S, 21A, 22I, 23E, 24G, 25V, 27E, 28T, 56R, 57Y, 58E, 60L, 61A, 64I, 67S, 71L, 72A, 74L, 75F, 77T, 78A, 79I, 81C, 82C, 83V, 85L, 86T, 93L, 94A, 97A, 100V, 103G, 104A, 107L, 108S, 111N, 115I, 118L, 119V
CDD
cd14266 (UDPK_IM_PAP2_like)

67S

trimer interface
19N, 20S, 21A, 22I, 23E, 24G, 25V, 27E, 28T, 56R, 57Y, 58E, 60L, 61A, 64I, 67S, 71L, 72A, 74L, 75F, 77T, 78A, 79I, 81C, 82C, 83V, 85L, 86T, 93L, 94A, 97A, 100V, 103G, 104A, 107L, 108S, 111N, 115I, 118L, 119V
CDD
cd14266 (UDPK_IM_PAP2_like)

71L

trimer interface
19N, 20S, 21A, 22I, 23E, 24G, 25V, 27E, 28T, 56R, 57Y, 58E, 60L, 61A, 64I, 67S, 71L, 72A, 74L, 75F, 77T, 78A, 79I, 81C, 82C, 83V, 85L, 86T, 93L, 94A, 97A, 100V, 103G, 104A, 107L, 108S, 111N, 115I, 118L, 119V
CDD
cd14266 (UDPK_IM_PAP2_like)

72A

trimer interface
19N, 20S, 21A, 22I, 23E, 24G, 25V, 27E, 28T, 56R, 57Y, 58E, 60L, 61A, 64I, 67S, 71L, 72A, 74L, 75F, 77T, 78A, 79I, 81C, 82C, 83V, 85L, 86T, 93L, 94A, 97A, 100V, 103G, 104A, 107L, 108S, 111N, 115I, 118L, 119V
CDD
cd14266 (UDPK_IM_PAP2_like)

74L

trimer interface
19N, 20S, 21A, 22I, 23E, 24G, 25V, 27E, 28T, 56R, 57Y, 58E, 60L, 61A, 64I, 67S, 71L, 72A, 74L, 75F, 77T, 78A, 79I, 81C, 82C, 83V, 85L, 86T, 93L, 94A, 97A, 100V, 103G, 104A, 107L, 108S, 111N, 115I, 118L, 119V
CDD
cd14266 (UDPK_IM_PAP2_like)

75F

trimer interface
19N, 20S, 21A, 22I, 23E, 24G, 25V, 27E, 28T, 56R, 57Y, 58E, 60L, 61A, 64I, 67S, 71L, 72A, 74L, 75F, 77T, 78A, 79I, 81C, 82C, 83V, 85L, 86T, 93L, 94A, 97A, 100V, 103G, 104A, 107L, 108S, 111N, 115I, 118L, 119V
CDD
cd14266 (UDPK_IM_PAP2_like)

77T

trimer interface
19N, 20S, 21A, 22I, 23E, 24G, 25V, 27E, 28T, 56R, 57Y, 58E, 60L, 61A, 64I, 67S, 71L, 72A, 74L, 75F, 77T, 78A, 79I, 81C, 82C, 83V, 85L, 86T, 93L, 94A, 97A, 100V, 103G, 104A, 107L, 108S, 111N, 115I, 118L, 119V
CDD
cd14266 (UDPK_IM_PAP2_like)

78A

trimer interface
19N, 20S, 21A, 22I, 23E, 24G, 25V, 27E, 28T, 56R, 57Y, 58E, 60L, 61A, 64I, 67S, 71L, 72A, 74L, 75F, 77T, 78A, 79I, 81C, 82C, 83V, 85L, 86T, 93L, 94A, 97A, 100V, 103G, 104A, 107L, 108S, 111N, 115I, 118L, 119V
CDD
cd14266 (UDPK_IM_PAP2_like)

79I

trimer interface
19N, 20S, 21A, 22I, 23E, 24G, 25V, 27E, 28T, 56R, 57Y, 58E, 60L, 61A, 64I, 67S, 71L, 72A, 74L, 75F, 77T, 78A, 79I, 81C, 82C, 83V, 85L, 86T, 93L, 94A, 97A, 100V, 103G, 104A, 107L, 108S, 111N, 115I, 118L, 119V
CDD
cd14266 (UDPK_IM_PAP2_like)

81C

trimer interface
19N, 20S, 21A, 22I, 23E, 24G, 25V, 27E, 28T, 56R, 57Y, 58E, 60L, 61A, 64I, 67S, 71L, 72A, 74L, 75F, 77T, 78A, 79I, 81C, 82C, 83V, 85L, 86T, 93L, 94A, 97A, 100V, 103G, 104A, 107L, 108S, 111N, 115I, 118L, 119V
CDD
cd14266 (UDPK_IM_PAP2_like)

82C

trimer interface
19N, 20S, 21A, 22I, 23E, 24G, 25V, 27E, 28T, 56R, 57Y, 58E, 60L, 61A, 64I, 67S, 71L, 72A, 74L, 75F, 77T, 78A, 79I, 81C, 82C, 83V, 85L, 86T, 93L, 94A, 97A, 100V, 103G, 104A, 107L, 108S, 111N, 115I, 118L, 119V
CDD
cd14266 (UDPK_IM_PAP2_like)

83V

trimer interface
19N, 20S, 21A, 22I, 23E, 24G, 25V, 27E, 28T, 56R, 57Y, 58E, 60L, 61A, 64I, 67S, 71L, 72A, 74L, 75F, 77T, 78A, 79I, 81C, 82C, 83V, 85L, 86T, 93L, 94A, 97A, 100V, 103G, 104A, 107L, 108S, 111N, 115I, 118L, 119V
CDD
cd14266 (UDPK_IM_PAP2_like)

85L

trimer interface
19N, 20S, 21A, 22I, 23E, 24G, 25V, 27E, 28T, 56R, 57Y, 58E, 60L, 61A, 64I, 67S, 71L, 72A, 74L, 75F, 77T, 78A, 79I, 81C, 82C, 83V, 85L, 86T, 93L, 94A, 97A, 100V, 103G, 104A, 107L, 108S, 111N, 115I, 118L, 119V
CDD
cd14266 (UDPK_IM_PAP2_like)

86T

trimer interface
19N, 20S, 21A, 22I, 23E, 24G, 25V, 27E, 28T, 56R, 57Y, 58E, 60L, 61A, 64I, 67S, 71L, 72A, 74L, 75F, 77T, 78A, 79I, 81C, 82C, 83V, 85L, 86T, 93L, 94A, 97A, 100V, 103G, 104A, 107L, 108S, 111N, 115I, 118L, 119V
CDD
cd14266 (UDPK_IM_PAP2_like)

93L

trimer interface
19N, 20S, 21A, 22I, 23E, 24G, 25V, 27E, 28T, 56R, 57Y, 58E, 60L, 61A, 64I, 67S, 71L, 72A, 74L, 75F, 77T, 78A, 79I, 81C, 82C, 83V, 85L, 86T, 93L, 94A, 97A, 100V, 103G, 104A, 107L, 108S, 111N, 115I, 118L, 119V
CDD
cd14266 (UDPK_IM_PAP2_like)

94A

trimer interface
19N, 20S, 21A, 22I, 23E, 24G, 25V, 27E, 28T, 56R, 57Y, 58E, 60L, 61A, 64I, 67S, 71L, 72A, 74L, 75F, 77T, 78A, 79I, 81C, 82C, 83V, 85L, 86T, 93L, 94A, 97A, 100V, 103G, 104A, 107L, 108S, 111N, 115I, 118L, 119V
CDD
cd14266 (UDPK_IM_PAP2_like)

97A

trimer interface
19N, 20S, 21A, 22I, 23E, 24G, 25V, 27E, 28T, 56R, 57Y, 58E, 60L, 61A, 64I, 67S, 71L, 72A, 74L, 75F, 77T, 78A, 79I, 81C, 82C, 83V, 85L, 86T, 93L, 94A, 97A, 100V, 103G, 104A, 107L, 108S, 111N, 115I, 118L, 119V
CDD
cd14266 (UDPK_IM_PAP2_like)

100V

trimer interface
19N, 20S, 21A, 22I, 23E, 24G, 25V, 27E, 28T, 56R, 57Y, 58E, 60L, 61A, 64I, 67S, 71L, 72A, 74L, 75F, 77T, 78A, 79I, 81C, 82C, 83V, 85L, 86T, 93L, 94A, 97A, 100V, 103G, 104A, 107L, 108S, 111N, 115I, 118L, 119V
CDD
cd14266 (UDPK_IM_PAP2_like)

103G

trimer interface
19N, 20S, 21A, 22I, 23E, 24G, 25V, 27E, 28T, 56R, 57Y, 58E, 60L, 61A, 64I, 67S, 71L, 72A, 74L, 75F, 77T, 78A, 79I, 81C, 82C, 83V, 85L, 86T, 93L, 94A, 97A, 100V, 103G, 104A, 107L, 108S, 111N, 115I, 118L, 119V
CDD
cd14266 (UDPK_IM_PAP2_like)

104A

trimer interface
19N, 20S, 21A, 22I, 23E, 24G, 25V, 27E, 28T, 56R, 57Y, 58E, 60L, 61A, 64I, 67S, 71L, 72A, 74L, 75F, 77T, 78A, 79I, 81C, 82C, 83V, 85L, 86T, 93L, 94A, 97A, 100V, 103G, 104A, 107L, 108S, 111N, 115I, 118L, 119V
CDD
cd14266 (UDPK_IM_PAP2_like)

107L

trimer interface
19N, 20S, 21A, 22I, 23E, 24G, 25V, 27E, 28T, 56R, 57Y, 58E, 60L, 61A, 64I, 67S, 71L, 72A, 74L, 75F, 77T, 78A, 79I, 81C, 82C, 83V, 85L, 86T, 93L, 94A, 97A, 100V, 103G, 104A, 107L, 108S, 111N, 115I, 118L, 119V
CDD
cd14266 (UDPK_IM_PAP2_like)

108S

trimer interface
19N, 20S, 21A, 22I, 23E, 24G, 25V, 27E, 28T, 56R, 57Y, 58E, 60L, 61A, 64I, 67S, 71L, 72A, 74L, 75F, 77T, 78A, 79I, 81C, 82C, 83V, 85L, 86T, 93L, 94A, 97A, 100V, 103G, 104A, 107L, 108S, 111N, 115I, 118L, 119V
CDD
cd14266 (UDPK_IM_PAP2_like)

111N

trimer interface
19N, 20S, 21A, 22I, 23E, 24G, 25V, 27E, 28T, 56R, 57Y, 58E, 60L, 61A, 64I, 67S, 71L, 72A, 74L, 75F, 77T, 78A, 79I, 81C, 82C, 83V, 85L, 86T, 93L, 94A, 97A, 100V, 103G, 104A, 107L, 108S, 111N, 115I, 118L, 119V
CDD
cd14266 (UDPK_IM_PAP2_like)

115I

trimer interface
19N, 20S, 21A, 22I, 23E, 24G, 25V, 27E, 28T, 56R, 57Y, 58E, 60L, 61A, 64I, 67S, 71L, 72A, 74L, 75F, 77T, 78A, 79I, 81C, 82C, 83V, 85L, 86T, 93L, 94A, 97A, 100V, 103G, 104A, 107L, 108S, 111N, 115I, 118L, 119V
CDD
cd14266 (UDPK_IM_PAP2_like)

118L

trimer interface
19N, 20S, 21A, 22I, 23E, 24G, 25V, 27E, 28T, 56R, 57Y, 58E, 60L, 61A, 64I, 67S, 71L, 72A, 74L, 75F, 77T, 78A, 79I, 81C, 82C, 83V, 85L, 86T, 93L, 94A, 97A, 100V, 103G, 104A, 107L, 108S, 111N, 115I, 118L, 119V
CDD
cd14266 (UDPK_IM_PAP2_like)

119V

trimer interface
19N, 20S, 21A, 22I, 23E, 24G, 25V, 27E, 28T, 56R, 57Y, 58E, 60L, 61A, 64I, 67S, 71L, 72A, 74L, 75F, 77T, 78A, 79I, 81C, 82C, 83V, 85L, 86T, 93L, 94A, 97A, 100V, 103G, 104A, 107L, 108S, 111N, 115I, 118L, 119V
CDD
cd14266 (UDPK_IM_PAP2_like)
putative active si...

23E

putative active site
23E, 32E, 73E, 80E, 84D, 98K, 99D
CDD
cd14266 (UDPK_IM_PAP2_like)

32E

putative active site
23E, 32E, 73E, 80E, 84D, 98K, 99D
CDD
cd14266 (UDPK_IM_PAP2_like)

73E

putative active site
23E, 32E, 73E, 80E, 84D, 98K, 99D
CDD
cd14266 (UDPK_IM_PAP2_like)

80E

putative active site
23E, 32E, 73E, 80E, 84D, 98K, 99D
CDD
cd14266 (UDPK_IM_PAP2_like)

84D

putative active site
23E, 32E, 73E, 80E, 84D, 98K, 99D
CDD
cd14266 (UDPK_IM_PAP2_like)

98K

putative active site
23E, 32E, 73E, 80E, 84D, 98K, 99D
CDD
cd14266 (UDPK_IM_PAP2_like)

99D

putative active site
23E, 32E, 73E, 80E, 84D, 98K, 99D
CDD
cd14266 (UDPK_IM_PAP2_like)
Zn binding site cd...

32E

Zn binding site
32E, 80E
CDD
cd14266 (UDPK_IM_PAP2_like)

80E

Zn binding site
32E, 80E
CDD
cd14266 (UDPK_IM_PAP2_like)
active site cd03383

158K

active site
158K, 165T, 173S, 174G, 175H, 210R, 216H, 220E
CDD
cd03383 (PAP2_diacylglycerolkinase)

165T

active site
158K, 165T, 173S, 174G, 175H, 210R, 216H, 220E
CDD
cd03383 (PAP2_diacylglycerolkinase)

173S

active site
158K, 165T, 173S, 174G, 175H, 210R, 216H, 220E
CDD
cd03383 (PAP2_diacylglycerolkinase)

174G

active site
158K, 165T, 173S, 174G, 175H, 210R, 216H, 220E
CDD
cd03383 (PAP2_diacylglycerolkinase)

175H

active site
158K, 165T, 173S, 174G, 175H, 210R, 216H, 220E
CDD
cd03383 (PAP2_diacylglycerolkinase)

210R

active site
158K, 165T, 173S, 174G, 175H, 210R, 216H, 220E
CDD
cd03383 (PAP2_diacylglycerolkinase)

216H

active site
158K, 165T, 173S, 174G, 175H, 210R, 216H, 220E
CDD
cd03383 (PAP2_diacylglycerolkinase)

220E

active site
158K, 165T, 173S, 174G, 175H, 210R, 216H, 220E
CDD
cd03383 (PAP2_diacylglycerolkinase)

GO term prediction

Biological Process

GO:0008610 lipid biosynthetic process
GO:0008654 phospholipid biosynthetic process

Molecular Function

GO:0016301 kinase activity

Cellular Component

GO:0016020 membrane

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Entry type

Status

Per-residue features

1_1_36S_FusoPortal_Gene_1731

Protein family membership

Homologous superfamilies

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component