1_1_36S_FusoPortal_Gene_195

Protein

1_1_36S_FusoPortal_Gene_195

Length

186 amino acids

Protein family membership

GrpE nucleotide exchange factor (IPR000740)

Homologous superfamilies

Homologous superfamily
1 - 126
GrpE nucleotide exchange factor, coiled-coil (IPR013805)
128 - 184
GrpE nucleotide exchange factor, head (IPR009012)

1 20 40 60 80 100 120 140 160 186

Domains and repeats

None predicted.

Detailed signature matches

IPR013805

GrpE nucleotide exchange factor, coiled-coil
1. G3DSA:3.90.20.20
  
  1 - 126
  
  GENE3D
  G3DSA:3.90.20.20 (G3DSA:3.90.20.20)
IPR009012

GrpE nucleotide exchange factor, head
1. SSF51064 (Head doma...)
  
  129 - 184
  
  SUPERFAMILY
  SSF51064 (Head domain of nucleotide exchange factor GrpE)
2. G3DSA:2.30.22.10
  
  128 - 184
  
  GENE3D
  G3DSA:2.30.22.10 (G3DSA:2.30.22.10)
IPR000740

GrpE nucleotide exchange factor
1. MF_01151 (GrpE)
  
  2 - 184
  
  HAMAP
  MF_01151 (GrpE)
2. PR00773 (GRPEPROTEIN)
  
  136 - 151
  
  PRINTS
  PR00773 (GRPEPROTEIN)
  
  82 - 97
  
  PRINTS
  PR00773 (GRPEPROTEIN)
  
  54 - 70
  
  PRINTS
  PR00773 (GRPEPROTEIN)
  
  163 - 182
  
  PRINTS
  PR00773 (GRPEPROTEIN)
3. PS01071 (GRPE)
  
  139 - 182
  
  PROSITE patterns
  PS01071 (GRPE)
4. PTHR21237 (GRPE PRO...)
  
  9 - 183
  
  PANTHER
  PTHR21237 (GRPE PROTEIN)
5. cd00446 (GrpE)
  
  47 - 182
  
  CDD
  cd00446 (GrpE)
6. PF01025 (GrpE)
  
  21 - 184
  
  Pfam
  PF01025 (GrpE)

no IPR

Unintegrated signatures

Coil

4 - 31

COILS
Coil (Coil)

83 - 103

COILS
Coil (Coil)
SSF58014 (Coiled-co...)

35 - 128

SUPERFAMILY
SSF58014 (Coiled-coil domain of nucleotide exchange factor GrpE)

Residue annotation

dimer interface cd...

49W

dimer interface
49W, 52S, 53Y, 56K, 57Q, 59D, 60F, 63F, 64T, 65K, 67K, 70E, 71I, 74L, 75R, 78S, 79S, 81K, 82I, 85K, 86L, 87L, 89S, 90L, 91D, 92N, 93L, 95R, 96A, 112G, 113V, 115M, 116I, 117L, 120I, 126S, 127E
CDD
cd00446 (GrpE)

52S

dimer interface
49W, 52S, 53Y, 56K, 57Q, 59D, 60F, 63F, 64T, 65K, 67K, 70E, 71I, 74L, 75R, 78S, 79S, 81K, 82I, 85K, 86L, 87L, 89S, 90L, 91D, 92N, 93L, 95R, 96A, 112G, 113V, 115M, 116I, 117L, 120I, 126S, 127E
CDD
cd00446 (GrpE)

53Y

dimer interface
49W, 52S, 53Y, 56K, 57Q, 59D, 60F, 63F, 64T, 65K, 67K, 70E, 71I, 74L, 75R, 78S, 79S, 81K, 82I, 85K, 86L, 87L, 89S, 90L, 91D, 92N, 93L, 95R, 96A, 112G, 113V, 115M, 116I, 117L, 120I, 126S, 127E
CDD
cd00446 (GrpE)

56K

dimer interface
49W, 52S, 53Y, 56K, 57Q, 59D, 60F, 63F, 64T, 65K, 67K, 70E, 71I, 74L, 75R, 78S, 79S, 81K, 82I, 85K, 86L, 87L, 89S, 90L, 91D, 92N, 93L, 95R, 96A, 112G, 113V, 115M, 116I, 117L, 120I, 126S, 127E
CDD
cd00446 (GrpE)

57Q

dimer interface
49W, 52S, 53Y, 56K, 57Q, 59D, 60F, 63F, 64T, 65K, 67K, 70E, 71I, 74L, 75R, 78S, 79S, 81K, 82I, 85K, 86L, 87L, 89S, 90L, 91D, 92N, 93L, 95R, 96A, 112G, 113V, 115M, 116I, 117L, 120I, 126S, 127E
CDD
cd00446 (GrpE)

59D

dimer interface
49W, 52S, 53Y, 56K, 57Q, 59D, 60F, 63F, 64T, 65K, 67K, 70E, 71I, 74L, 75R, 78S, 79S, 81K, 82I, 85K, 86L, 87L, 89S, 90L, 91D, 92N, 93L, 95R, 96A, 112G, 113V, 115M, 116I, 117L, 120I, 126S, 127E
CDD
cd00446 (GrpE)

60F

dimer interface
49W, 52S, 53Y, 56K, 57Q, 59D, 60F, 63F, 64T, 65K, 67K, 70E, 71I, 74L, 75R, 78S, 79S, 81K, 82I, 85K, 86L, 87L, 89S, 90L, 91D, 92N, 93L, 95R, 96A, 112G, 113V, 115M, 116I, 117L, 120I, 126S, 127E
CDD
cd00446 (GrpE)

63F

dimer interface
49W, 52S, 53Y, 56K, 57Q, 59D, 60F, 63F, 64T, 65K, 67K, 70E, 71I, 74L, 75R, 78S, 79S, 81K, 82I, 85K, 86L, 87L, 89S, 90L, 91D, 92N, 93L, 95R, 96A, 112G, 113V, 115M, 116I, 117L, 120I, 126S, 127E
CDD
cd00446 (GrpE)

64T

dimer interface
49W, 52S, 53Y, 56K, 57Q, 59D, 60F, 63F, 64T, 65K, 67K, 70E, 71I, 74L, 75R, 78S, 79S, 81K, 82I, 85K, 86L, 87L, 89S, 90L, 91D, 92N, 93L, 95R, 96A, 112G, 113V, 115M, 116I, 117L, 120I, 126S, 127E
CDD
cd00446 (GrpE)

65K

dimer interface
49W, 52S, 53Y, 56K, 57Q, 59D, 60F, 63F, 64T, 65K, 67K, 70E, 71I, 74L, 75R, 78S, 79S, 81K, 82I, 85K, 86L, 87L, 89S, 90L, 91D, 92N, 93L, 95R, 96A, 112G, 113V, 115M, 116I, 117L, 120I, 126S, 127E
CDD
cd00446 (GrpE)

67K

dimer interface
49W, 52S, 53Y, 56K, 57Q, 59D, 60F, 63F, 64T, 65K, 67K, 70E, 71I, 74L, 75R, 78S, 79S, 81K, 82I, 85K, 86L, 87L, 89S, 90L, 91D, 92N, 93L, 95R, 96A, 112G, 113V, 115M, 116I, 117L, 120I, 126S, 127E
CDD
cd00446 (GrpE)

70E

dimer interface
49W, 52S, 53Y, 56K, 57Q, 59D, 60F, 63F, 64T, 65K, 67K, 70E, 71I, 74L, 75R, 78S, 79S, 81K, 82I, 85K, 86L, 87L, 89S, 90L, 91D, 92N, 93L, 95R, 96A, 112G, 113V, 115M, 116I, 117L, 120I, 126S, 127E
CDD
cd00446 (GrpE)

71I

dimer interface
49W, 52S, 53Y, 56K, 57Q, 59D, 60F, 63F, 64T, 65K, 67K, 70E, 71I, 74L, 75R, 78S, 79S, 81K, 82I, 85K, 86L, 87L, 89S, 90L, 91D, 92N, 93L, 95R, 96A, 112G, 113V, 115M, 116I, 117L, 120I, 126S, 127E
CDD
cd00446 (GrpE)

74L

dimer interface
49W, 52S, 53Y, 56K, 57Q, 59D, 60F, 63F, 64T, 65K, 67K, 70E, 71I, 74L, 75R, 78S, 79S, 81K, 82I, 85K, 86L, 87L, 89S, 90L, 91D, 92N, 93L, 95R, 96A, 112G, 113V, 115M, 116I, 117L, 120I, 126S, 127E
CDD
cd00446 (GrpE)

75R

dimer interface
49W, 52S, 53Y, 56K, 57Q, 59D, 60F, 63F, 64T, 65K, 67K, 70E, 71I, 74L, 75R, 78S, 79S, 81K, 82I, 85K, 86L, 87L, 89S, 90L, 91D, 92N, 93L, 95R, 96A, 112G, 113V, 115M, 116I, 117L, 120I, 126S, 127E
CDD
cd00446 (GrpE)

78S

dimer interface
49W, 52S, 53Y, 56K, 57Q, 59D, 60F, 63F, 64T, 65K, 67K, 70E, 71I, 74L, 75R, 78S, 79S, 81K, 82I, 85K, 86L, 87L, 89S, 90L, 91D, 92N, 93L, 95R, 96A, 112G, 113V, 115M, 116I, 117L, 120I, 126S, 127E
CDD
cd00446 (GrpE)

79S

dimer interface
49W, 52S, 53Y, 56K, 57Q, 59D, 60F, 63F, 64T, 65K, 67K, 70E, 71I, 74L, 75R, 78S, 79S, 81K, 82I, 85K, 86L, 87L, 89S, 90L, 91D, 92N, 93L, 95R, 96A, 112G, 113V, 115M, 116I, 117L, 120I, 126S, 127E
CDD
cd00446 (GrpE)

81K

dimer interface
49W, 52S, 53Y, 56K, 57Q, 59D, 60F, 63F, 64T, 65K, 67K, 70E, 71I, 74L, 75R, 78S, 79S, 81K, 82I, 85K, 86L, 87L, 89S, 90L, 91D, 92N, 93L, 95R, 96A, 112G, 113V, 115M, 116I, 117L, 120I, 126S, 127E
CDD
cd00446 (GrpE)

82I

dimer interface
49W, 52S, 53Y, 56K, 57Q, 59D, 60F, 63F, 64T, 65K, 67K, 70E, 71I, 74L, 75R, 78S, 79S, 81K, 82I, 85K, 86L, 87L, 89S, 90L, 91D, 92N, 93L, 95R, 96A, 112G, 113V, 115M, 116I, 117L, 120I, 126S, 127E
CDD
cd00446 (GrpE)

85K

dimer interface
49W, 52S, 53Y, 56K, 57Q, 59D, 60F, 63F, 64T, 65K, 67K, 70E, 71I, 74L, 75R, 78S, 79S, 81K, 82I, 85K, 86L, 87L, 89S, 90L, 91D, 92N, 93L, 95R, 96A, 112G, 113V, 115M, 116I, 117L, 120I, 126S, 127E
CDD
cd00446 (GrpE)

86L

dimer interface
49W, 52S, 53Y, 56K, 57Q, 59D, 60F, 63F, 64T, 65K, 67K, 70E, 71I, 74L, 75R, 78S, 79S, 81K, 82I, 85K, 86L, 87L, 89S, 90L, 91D, 92N, 93L, 95R, 96A, 112G, 113V, 115M, 116I, 117L, 120I, 126S, 127E
CDD
cd00446 (GrpE)

87L

dimer interface
49W, 52S, 53Y, 56K, 57Q, 59D, 60F, 63F, 64T, 65K, 67K, 70E, 71I, 74L, 75R, 78S, 79S, 81K, 82I, 85K, 86L, 87L, 89S, 90L, 91D, 92N, 93L, 95R, 96A, 112G, 113V, 115M, 116I, 117L, 120I, 126S, 127E
CDD
cd00446 (GrpE)

89S

dimer interface
49W, 52S, 53Y, 56K, 57Q, 59D, 60F, 63F, 64T, 65K, 67K, 70E, 71I, 74L, 75R, 78S, 79S, 81K, 82I, 85K, 86L, 87L, 89S, 90L, 91D, 92N, 93L, 95R, 96A, 112G, 113V, 115M, 116I, 117L, 120I, 126S, 127E
CDD
cd00446 (GrpE)

90L

dimer interface
49W, 52S, 53Y, 56K, 57Q, 59D, 60F, 63F, 64T, 65K, 67K, 70E, 71I, 74L, 75R, 78S, 79S, 81K, 82I, 85K, 86L, 87L, 89S, 90L, 91D, 92N, 93L, 95R, 96A, 112G, 113V, 115M, 116I, 117L, 120I, 126S, 127E
CDD
cd00446 (GrpE)

91D

dimer interface
49W, 52S, 53Y, 56K, 57Q, 59D, 60F, 63F, 64T, 65K, 67K, 70E, 71I, 74L, 75R, 78S, 79S, 81K, 82I, 85K, 86L, 87L, 89S, 90L, 91D, 92N, 93L, 95R, 96A, 112G, 113V, 115M, 116I, 117L, 120I, 126S, 127E
CDD
cd00446 (GrpE)

92N

dimer interface
49W, 52S, 53Y, 56K, 57Q, 59D, 60F, 63F, 64T, 65K, 67K, 70E, 71I, 74L, 75R, 78S, 79S, 81K, 82I, 85K, 86L, 87L, 89S, 90L, 91D, 92N, 93L, 95R, 96A, 112G, 113V, 115M, 116I, 117L, 120I, 126S, 127E
CDD
cd00446 (GrpE)

93L

dimer interface
49W, 52S, 53Y, 56K, 57Q, 59D, 60F, 63F, 64T, 65K, 67K, 70E, 71I, 74L, 75R, 78S, 79S, 81K, 82I, 85K, 86L, 87L, 89S, 90L, 91D, 92N, 93L, 95R, 96A, 112G, 113V, 115M, 116I, 117L, 120I, 126S, 127E
CDD
cd00446 (GrpE)

95R

dimer interface
49W, 52S, 53Y, 56K, 57Q, 59D, 60F, 63F, 64T, 65K, 67K, 70E, 71I, 74L, 75R, 78S, 79S, 81K, 82I, 85K, 86L, 87L, 89S, 90L, 91D, 92N, 93L, 95R, 96A, 112G, 113V, 115M, 116I, 117L, 120I, 126S, 127E
CDD
cd00446 (GrpE)

96A

dimer interface
49W, 52S, 53Y, 56K, 57Q, 59D, 60F, 63F, 64T, 65K, 67K, 70E, 71I, 74L, 75R, 78S, 79S, 81K, 82I, 85K, 86L, 87L, 89S, 90L, 91D, 92N, 93L, 95R, 96A, 112G, 113V, 115M, 116I, 117L, 120I, 126S, 127E
CDD
cd00446 (GrpE)

112G

dimer interface
49W, 52S, 53Y, 56K, 57Q, 59D, 60F, 63F, 64T, 65K, 67K, 70E, 71I, 74L, 75R, 78S, 79S, 81K, 82I, 85K, 86L, 87L, 89S, 90L, 91D, 92N, 93L, 95R, 96A, 112G, 113V, 115M, 116I, 117L, 120I, 126S, 127E
CDD
cd00446 (GrpE)

113V

dimer interface
49W, 52S, 53Y, 56K, 57Q, 59D, 60F, 63F, 64T, 65K, 67K, 70E, 71I, 74L, 75R, 78S, 79S, 81K, 82I, 85K, 86L, 87L, 89S, 90L, 91D, 92N, 93L, 95R, 96A, 112G, 113V, 115M, 116I, 117L, 120I, 126S, 127E
CDD
cd00446 (GrpE)

115M

dimer interface
49W, 52S, 53Y, 56K, 57Q, 59D, 60F, 63F, 64T, 65K, 67K, 70E, 71I, 74L, 75R, 78S, 79S, 81K, 82I, 85K, 86L, 87L, 89S, 90L, 91D, 92N, 93L, 95R, 96A, 112G, 113V, 115M, 116I, 117L, 120I, 126S, 127E
CDD
cd00446 (GrpE)

116I

dimer interface
49W, 52S, 53Y, 56K, 57Q, 59D, 60F, 63F, 64T, 65K, 67K, 70E, 71I, 74L, 75R, 78S, 79S, 81K, 82I, 85K, 86L, 87L, 89S, 90L, 91D, 92N, 93L, 95R, 96A, 112G, 113V, 115M, 116I, 117L, 120I, 126S, 127E
CDD
cd00446 (GrpE)

117L

dimer interface
49W, 52S, 53Y, 56K, 57Q, 59D, 60F, 63F, 64T, 65K, 67K, 70E, 71I, 74L, 75R, 78S, 79S, 81K, 82I, 85K, 86L, 87L, 89S, 90L, 91D, 92N, 93L, 95R, 96A, 112G, 113V, 115M, 116I, 117L, 120I, 126S, 127E
CDD
cd00446 (GrpE)

120I

dimer interface
49W, 52S, 53Y, 56K, 57Q, 59D, 60F, 63F, 64T, 65K, 67K, 70E, 71I, 74L, 75R, 78S, 79S, 81K, 82I, 85K, 86L, 87L, 89S, 90L, 91D, 92N, 93L, 95R, 96A, 112G, 113V, 115M, 116I, 117L, 120I, 126S, 127E
CDD
cd00446 (GrpE)

126S

dimer interface
49W, 52S, 53Y, 56K, 57Q, 59D, 60F, 63F, 64T, 65K, 67K, 70E, 71I, 74L, 75R, 78S, 79S, 81K, 82I, 85K, 86L, 87L, 89S, 90L, 91D, 92N, 93L, 95R, 96A, 112G, 113V, 115M, 116I, 117L, 120I, 126S, 127E
CDD
cd00446 (GrpE)

127E

dimer interface
49W, 52S, 53Y, 56K, 57Q, 59D, 60F, 63F, 64T, 65K, 67K, 70E, 71I, 74L, 75R, 78S, 79S, 81K, 82I, 85K, 86L, 87L, 89S, 90L, 91D, 92N, 93L, 95R, 96A, 112G, 113V, 115M, 116I, 117L, 120I, 126S, 127E
CDD
cd00446 (GrpE)
Hsp70 (ATPase doma...

65K

Hsp70 (ATPase domain) interactions
65K, 73E, 95R, 98S, 139F, 141P, 142M, 144H, 145H, 146A, 147V, 148M, 164L, 173K, 177P, 179M, 182V
CDD
cd00446 (GrpE)

73E

Hsp70 (ATPase domain) interactions
65K, 73E, 95R, 98S, 139F, 141P, 142M, 144H, 145H, 146A, 147V, 148M, 164L, 173K, 177P, 179M, 182V
CDD
cd00446 (GrpE)

95R

Hsp70 (ATPase domain) interactions
65K, 73E, 95R, 98S, 139F, 141P, 142M, 144H, 145H, 146A, 147V, 148M, 164L, 173K, 177P, 179M, 182V
CDD
cd00446 (GrpE)

98S

Hsp70 (ATPase domain) interactions
65K, 73E, 95R, 98S, 139F, 141P, 142M, 144H, 145H, 146A, 147V, 148M, 164L, 173K, 177P, 179M, 182V
CDD
cd00446 (GrpE)

139F

Hsp70 (ATPase domain) interactions
65K, 73E, 95R, 98S, 139F, 141P, 142M, 144H, 145H, 146A, 147V, 148M, 164L, 173K, 177P, 179M, 182V
CDD
cd00446 (GrpE)

141P

Hsp70 (ATPase domain) interactions
65K, 73E, 95R, 98S, 139F, 141P, 142M, 144H, 145H, 146A, 147V, 148M, 164L, 173K, 177P, 179M, 182V
CDD
cd00446 (GrpE)

142M

Hsp70 (ATPase domain) interactions
65K, 73E, 95R, 98S, 139F, 141P, 142M, 144H, 145H, 146A, 147V, 148M, 164L, 173K, 177P, 179M, 182V
CDD
cd00446 (GrpE)

144H

Hsp70 (ATPase domain) interactions
65K, 73E, 95R, 98S, 139F, 141P, 142M, 144H, 145H, 146A, 147V, 148M, 164L, 173K, 177P, 179M, 182V
CDD
cd00446 (GrpE)

145H

Hsp70 (ATPase domain) interactions
65K, 73E, 95R, 98S, 139F, 141P, 142M, 144H, 145H, 146A, 147V, 148M, 164L, 173K, 177P, 179M, 182V
CDD
cd00446 (GrpE)

146A

Hsp70 (ATPase domain) interactions
65K, 73E, 95R, 98S, 139F, 141P, 142M, 144H, 145H, 146A, 147V, 148M, 164L, 173K, 177P, 179M, 182V
CDD
cd00446 (GrpE)

147V

Hsp70 (ATPase domain) interactions
65K, 73E, 95R, 98S, 139F, 141P, 142M, 144H, 145H, 146A, 147V, 148M, 164L, 173K, 177P, 179M, 182V
CDD
cd00446 (GrpE)

148M

Hsp70 (ATPase domain) interactions
65K, 73E, 95R, 98S, 139F, 141P, 142M, 144H, 145H, 146A, 147V, 148M, 164L, 173K, 177P, 179M, 182V
CDD
cd00446 (GrpE)

164L

Hsp70 (ATPase domain) interactions
65K, 73E, 95R, 98S, 139F, 141P, 142M, 144H, 145H, 146A, 147V, 148M, 164L, 173K, 177P, 179M, 182V
CDD
cd00446 (GrpE)

173K

Hsp70 (ATPase domain) interactions
65K, 73E, 95R, 98S, 139F, 141P, 142M, 144H, 145H, 146A, 147V, 148M, 164L, 173K, 177P, 179M, 182V
CDD
cd00446 (GrpE)

177P

Hsp70 (ATPase domain) interactions
65K, 73E, 95R, 98S, 139F, 141P, 142M, 144H, 145H, 146A, 147V, 148M, 164L, 173K, 177P, 179M, 182V
CDD
cd00446 (GrpE)

179M

Hsp70 (ATPase domain) interactions
65K, 73E, 95R, 98S, 139F, 141P, 142M, 144H, 145H, 146A, 147V, 148M, 164L, 173K, 177P, 179M, 182V
CDD
cd00446 (GrpE)

182V

Hsp70 (ATPase domain) interactions
65K, 73E, 95R, 98S, 139F, 141P, 142M, 144H, 145H, 146A, 147V, 148M, 164L, 173K, 177P, 179M, 182V
CDD
cd00446 (GrpE)

GO term prediction

Biological Process

GO:0006457 protein folding

Molecular Function

GO:0000774 adenyl-nucleotide exchange factor activity
GO:0042803 protein homodimerization activity
GO:0051087 chaperone binding

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features

1_1_36S_FusoPortal_Gene_195

Protein family membership

Homologous superfamilies

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component