1_1_36S_FusoPortal_Gene_2067

Protein

1_1_36S_FusoPortal_Gene_2067

Length

749 amino acids

Protein family membership

DNA topoisomerase I, type IA (IPR028612)
- DNA topoisomerase I, bacterial-type (IPR005733)

Homologous superfamilies

Homologous superfamily
4 - 554
DNA topoisomerase, type IA, core domain (IPR023405)
Homologous superfamily
326 - 449
DNA topoisomerase, type IA, central region, subdomain 2 (IPR013825)

1 100 200 300 400 500 600 749

Domains and repeats

Domain
4 - 126
TOPRIM domain (IPR006171)
DNA topoisomerase 1, TOPRIM domain (IPR034149)
712 - 749
DNA topoisomerase, type IA, zn finger (IPR013498)
Domain
78 - 91
DNA topoisomerase, type IA, central (IPR013497)
129 - 549
DNA topoisomerase, type IA, central (IPR013497)

1 100 200 300 400 500 600 749

Detailed signature matches

IPR023405

DNA topoisomerase, type IA, core domain
1. SSF56712 (Prokaryot...)
  
  4 - 554
  
  SUPERFAMILY
  SSF56712 (Prokaryotic type I DNA topoisomerase)
IPR013825

DNA topoisomerase, type IA, central region, subdomain 2
1. G3DSA:2.70.20.10
  
  326 - 449
  
  GENE3D
  G3DSA:2.70.20.10 (G3DSA:2.70.20.10)
IPR028612

DNA topoisomerase I, type IA
1. MF_00952 (Topoisom_...)
  
  4 - 631
  
  HAMAP
  MF_00952 (Topoisom_1_prok)
IPR005733

DNA topoisomerase I, bacterial-type
1. TIGR01051
  
  6 - 593
  
  TIGRFAMs
  TIGR01051 (TIGR01051)
IPR006171

TOPRIM domain
1. PF01751 (Toprim)
  
  6 - 114
  
  Pfam
  PF01751 (Toprim)
2. PS50880 (TOPRIM)
  
  4 - 114
  
  PROSITE profiles
  PS50880 (TOPRIM)
IPR034149

DNA topoisomerase 1, TOPRIM domain
1. cd03363 (TOPRIM_Top...)
  
  4 - 126
  
  CDD
  cd03363 (TOPRIM_TopoIA_TopoI)
IPR013497

DNA topoisomerase, type IA, central
1. PR00417 (PRTPISMRASEI)
  
  163 - 181
  
  PRINTS
  PR00417 (PRTPISMRASEI)
  
  78 - 91
  
  PRINTS
  PR00417 (PRTPISMRASEI)
  
  466 - 480
  
  PRINTS
  PR00417 (PRTPISMRASEI)
  
  367 - 383
  
  PRINTS
  PR00417 (PRTPISMRASEI)
  
  290 - 299
  
  PRINTS
  PR00417 (PRTPISMRASEI)
2. PF01131 (Topoisom_bac)
  
  129 - 540
  
  Pfam
  PF01131 (Topoisom_bac)
3. cd00186 (TOP1Ac)
  
  131 - 549
  
  CDD
  cd00186 (TOP1Ac)
IPR013498

DNA topoisomerase, type IA, zn finger
1. PF01396 (zf-C4_Topo...)
  
  712 - 749
  
  Pfam
  PF01396 (zf-C4_Topoisom)
IPR023406

DNA topoisomerase, type IA, active site
1. PS00396 (TOPOISOMER...)
  
  277 - 299
  
  PROSITE patterns
  PS00396 (TOPOISOMERASE_I_PROK)

no IPR

Unintegrated signatures

Coil

544 - 564

COILS
Coil (Coil)

690 - 710

COILS
Coil (Coil)
G3DSA:1.10.46...

136 - 325

GENE3D
G3DSA:1.10.460.10 (G3DSA:1.10.460.10)
G3DSA:3.30.65.10

693 - 749

GENE3D
G3DSA:3.30.65.10 (G3DSA:3.30.65.10)
G3DSA:3.40.50...

3 - 130

GENE3D
G3DSA:3.40.50.140 (G3DSA:3.40.50.140)
SSF57783 (Zinc beta...)

710 - 747

SUPERFAMILY
SSF57783 (Zinc beta-ribbon)

Residue annotation

active site cd03363

10E

active site
10E, 11S, 14K, 83D, 85D, 87E
CDD
cd03363 (TOPRIM_TopoIA_TopoI)

11S

active site
10E, 11S, 14K, 83D, 85D, 87E
CDD
cd03363 (TOPRIM_TopoIA_TopoI)

14K

active site
10E, 11S, 14K, 83D, 85D, 87E
CDD
cd03363 (TOPRIM_TopoIA_TopoI)

83D

active site
10E, 11S, 14K, 83D, 85D, 87E
CDD
cd03363 (TOPRIM_TopoIA_TopoI)

85D

active site
10E, 11S, 14K, 83D, 85D, 87E
CDD
cd03363 (TOPRIM_TopoIA_TopoI)

87E

active site
10E, 11S, 14K, 83D, 85D, 87E
CDD
cd03363 (TOPRIM_TopoIA_TopoI)
interdomain intera...

17T

interdomain interaction site
17T, 84P, 86R, 93W, 94H, 96A, 97N
CDD
cd03363 (TOPRIM_TopoIA_TopoI)

84P

interdomain interaction site
17T, 84P, 86R, 93W, 94H, 96A, 97N
CDD
cd03363 (TOPRIM_TopoIA_TopoI)

86R

interdomain interaction site
17T, 84P, 86R, 93W, 94H, 96A, 97N
CDD
cd03363 (TOPRIM_TopoIA_TopoI)

93W

interdomain interaction site
17T, 84P, 86R, 93W, 94H, 96A, 97N
CDD
cd03363 (TOPRIM_TopoIA_TopoI)

94H

interdomain interaction site
17T, 84P, 86R, 93W, 94H, 96A, 97N
CDD
cd03363 (TOPRIM_TopoIA_TopoI)

96A

interdomain interaction site
17T, 84P, 86R, 93W, 94H, 96A, 97N
CDD
cd03363 (TOPRIM_TopoIA_TopoI)

97N

interdomain interaction site
17T, 84P, 86R, 93W, 94H, 96A, 97N
CDD
cd03363 (TOPRIM_TopoIA_TopoI)
putative metal-bin...

83D

putative metal-binding site
83D, 85D
CDD
cd03363 (TOPRIM_TopoIA_TopoI)

85D

putative metal-binding site
83D, 85D
CDD
cd03363 (TOPRIM_TopoIA_TopoI)
nucleotide binding...

86R

nucleotide binding site
86R
CDD
cd03363 (TOPRIM_TopoIA_TopoI)
domain I cd00186

131T

domain I
131T, 132N, 133K, 134V, 135N, 136A, 137Q, 138Q, 139A, 140R, 141R, 142V, 143L, 144D, 145R, 146L, 147V, 148G, 149Y, 150E, 151I, 152S, 153P, 154F, 155L, 156W, 157K, 158L, 163T, 164S, 165A, 166G, 167R, 168V, 169Q, 170S, 171V, 172A, 173L, 174K, 175L, 176I, 177C, 178D, 179L, 180E, 181D, 182K, 183I
CDD
cd00186 (TOP1Ac)

132N

domain I
131T, 132N, 133K, 134V, 135N, 136A, 137Q, 138Q, 139A, 140R, 141R, 142V, 143L, 144D, 145R, 146L, 147V, 148G, 149Y, 150E, 151I, 152S, 153P, 154F, 155L, 156W, 157K, 158L, 163T, 164S, 165A, 166G, 167R, 168V, 169Q, 170S, 171V, 172A, 173L, 174K, 175L, 176I, 177C, 178D, 179L, 180E, 181D, 182K, 183I
CDD
cd00186 (TOP1Ac)

133K

domain I
131T, 132N, 133K, 134V, 135N, 136A, 137Q, 138Q, 139A, 140R, 141R, 142V, 143L, 144D, 145R, 146L, 147V, 148G, 149Y, 150E, 151I, 152S, 153P, 154F, 155L, 156W, 157K, 158L, 163T, 164S, 165A, 166G, 167R, 168V, 169Q, 170S, 171V, 172A, 173L, 174K, 175L, 176I, 177C, 178D, 179L, 180E, 181D, 182K, 183I
CDD
cd00186 (TOP1Ac)

134V

domain I
131T, 132N, 133K, 134V, 135N, 136A, 137Q, 138Q, 139A, 140R, 141R, 142V, 143L, 144D, 145R, 146L, 147V, 148G, 149Y, 150E, 151I, 152S, 153P, 154F, 155L, 156W, 157K, 158L, 163T, 164S, 165A, 166G, 167R, 168V, 169Q, 170S, 171V, 172A, 173L, 174K, 175L, 176I, 177C, 178D, 179L, 180E, 181D, 182K, 183I
CDD
cd00186 (TOP1Ac)

135N

domain I
131T, 132N, 133K, 134V, 135N, 136A, 137Q, 138Q, 139A, 140R, 141R, 142V, 143L, 144D, 145R, 146L, 147V, 148G, 149Y, 150E, 151I, 152S, 153P, 154F, 155L, 156W, 157K, 158L, 163T, 164S, 165A, 166G, 167R, 168V, 169Q, 170S, 171V, 172A, 173L, 174K, 175L, 176I, 177C, 178D, 179L, 180E, 181D, 182K, 183I
CDD
cd00186 (TOP1Ac)

136A

domain I
131T, 132N, 133K, 134V, 135N, 136A, 137Q, 138Q, 139A, 140R, 141R, 142V, 143L, 144D, 145R, 146L, 147V, 148G, 149Y, 150E, 151I, 152S, 153P, 154F, 155L, 156W, 157K, 158L, 163T, 164S, 165A, 166G, 167R, 168V, 169Q, 170S, 171V, 172A, 173L, 174K, 175L, 176I, 177C, 178D, 179L, 180E, 181D, 182K, 183I
CDD
cd00186 (TOP1Ac)

137Q

domain I
131T, 132N, 133K, 134V, 135N, 136A, 137Q, 138Q, 139A, 140R, 141R, 142V, 143L, 144D, 145R, 146L, 147V, 148G, 149Y, 150E, 151I, 152S, 153P, 154F, 155L, 156W, 157K, 158L, 163T, 164S, 165A, 166G, 167R, 168V, 169Q, 170S, 171V, 172A, 173L, 174K, 175L, 176I, 177C, 178D, 179L, 180E, 181D, 182K, 183I
CDD
cd00186 (TOP1Ac)

138Q

domain I
131T, 132N, 133K, 134V, 135N, 136A, 137Q, 138Q, 139A, 140R, 141R, 142V, 143L, 144D, 145R, 146L, 147V, 148G, 149Y, 150E, 151I, 152S, 153P, 154F, 155L, 156W, 157K, 158L, 163T, 164S, 165A, 166G, 167R, 168V, 169Q, 170S, 171V, 172A, 173L, 174K, 175L, 176I, 177C, 178D, 179L, 180E, 181D, 182K, 183I
CDD
cd00186 (TOP1Ac)

139A

domain I
131T, 132N, 133K, 134V, 135N, 136A, 137Q, 138Q, 139A, 140R, 141R, 142V, 143L, 144D, 145R, 146L, 147V, 148G, 149Y, 150E, 151I, 152S, 153P, 154F, 155L, 156W, 157K, 158L, 163T, 164S, 165A, 166G, 167R, 168V, 169Q, 170S, 171V, 172A, 173L, 174K, 175L, 176I, 177C, 178D, 179L, 180E, 181D, 182K, 183I
CDD
cd00186 (TOP1Ac)

140R

domain I
131T, 132N, 133K, 134V, 135N, 136A, 137Q, 138Q, 139A, 140R, 141R, 142V, 143L, 144D, 145R, 146L, 147V, 148G, 149Y, 150E, 151I, 152S, 153P, 154F, 155L, 156W, 157K, 158L, 163T, 164S, 165A, 166G, 167R, 168V, 169Q, 170S, 171V, 172A, 173L, 174K, 175L, 176I, 177C, 178D, 179L, 180E, 181D, 182K, 183I
CDD
cd00186 (TOP1Ac)

141R

domain I
131T, 132N, 133K, 134V, 135N, 136A, 137Q, 138Q, 139A, 140R, 141R, 142V, 143L, 144D, 145R, 146L, 147V, 148G, 149Y, 150E, 151I, 152S, 153P, 154F, 155L, 156W, 157K, 158L, 163T, 164S, 165A, 166G, 167R, 168V, 169Q, 170S, 171V, 172A, 173L, 174K, 175L, 176I, 177C, 178D, 179L, 180E, 181D, 182K, 183I
CDD
cd00186 (TOP1Ac)

142V

domain I
131T, 132N, 133K, 134V, 135N, 136A, 137Q, 138Q, 139A, 140R, 141R, 142V, 143L, 144D, 145R, 146L, 147V, 148G, 149Y, 150E, 151I, 152S, 153P, 154F, 155L, 156W, 157K, 158L, 163T, 164S, 165A, 166G, 167R, 168V, 169Q, 170S, 171V, 172A, 173L, 174K, 175L, 176I, 177C, 178D, 179L, 180E, 181D, 182K, 183I
CDD
cd00186 (TOP1Ac)

143L

domain I
131T, 132N, 133K, 134V, 135N, 136A, 137Q, 138Q, 139A, 140R, 141R, 142V, 143L, 144D, 145R, 146L, 147V, 148G, 149Y, 150E, 151I, 152S, 153P, 154F, 155L, 156W, 157K, 158L, 163T, 164S, 165A, 166G, 167R, 168V, 169Q, 170S, 171V, 172A, 173L, 174K, 175L, 176I, 177C, 178D, 179L, 180E, 181D, 182K, 183I
CDD
cd00186 (TOP1Ac)

144D

domain I
131T, 132N, 133K, 134V, 135N, 136A, 137Q, 138Q, 139A, 140R, 141R, 142V, 143L, 144D, 145R, 146L, 147V, 148G, 149Y, 150E, 151I, 152S, 153P, 154F, 155L, 156W, 157K, 158L, 163T, 164S, 165A, 166G, 167R, 168V, 169Q, 170S, 171V, 172A, 173L, 174K, 175L, 176I, 177C, 178D, 179L, 180E, 181D, 182K, 183I
CDD
cd00186 (TOP1Ac)

145R

domain I
131T, 132N, 133K, 134V, 135N, 136A, 137Q, 138Q, 139A, 140R, 141R, 142V, 143L, 144D, 145R, 146L, 147V, 148G, 149Y, 150E, 151I, 152S, 153P, 154F, 155L, 156W, 157K, 158L, 163T, 164S, 165A, 166G, 167R, 168V, 169Q, 170S, 171V, 172A, 173L, 174K, 175L, 176I, 177C, 178D, 179L, 180E, 181D, 182K, 183I
CDD
cd00186 (TOP1Ac)

146L

domain I
131T, 132N, 133K, 134V, 135N, 136A, 137Q, 138Q, 139A, 140R, 141R, 142V, 143L, 144D, 145R, 146L, 147V, 148G, 149Y, 150E, 151I, 152S, 153P, 154F, 155L, 156W, 157K, 158L, 163T, 164S, 165A, 166G, 167R, 168V, 169Q, 170S, 171V, 172A, 173L, 174K, 175L, 176I, 177C, 178D, 179L, 180E, 181D, 182K, 183I
CDD
cd00186 (TOP1Ac)

147V

domain I
131T, 132N, 133K, 134V, 135N, 136A, 137Q, 138Q, 139A, 140R, 141R, 142V, 143L, 144D, 145R, 146L, 147V, 148G, 149Y, 150E, 151I, 152S, 153P, 154F, 155L, 156W, 157K, 158L, 163T, 164S, 165A, 166G, 167R, 168V, 169Q, 170S, 171V, 172A, 173L, 174K, 175L, 176I, 177C, 178D, 179L, 180E, 181D, 182K, 183I
CDD
cd00186 (TOP1Ac)

148G

domain I
131T, 132N, 133K, 134V, 135N, 136A, 137Q, 138Q, 139A, 140R, 141R, 142V, 143L, 144D, 145R, 146L, 147V, 148G, 149Y, 150E, 151I, 152S, 153P, 154F, 155L, 156W, 157K, 158L, 163T, 164S, 165A, 166G, 167R, 168V, 169Q, 170S, 171V, 172A, 173L, 174K, 175L, 176I, 177C, 178D, 179L, 180E, 181D, 182K, 183I
CDD
cd00186 (TOP1Ac)

149Y

domain I
131T, 132N, 133K, 134V, 135N, 136A, 137Q, 138Q, 139A, 140R, 141R, 142V, 143L, 144D, 145R, 146L, 147V, 148G, 149Y, 150E, 151I, 152S, 153P, 154F, 155L, 156W, 157K, 158L, 163T, 164S, 165A, 166G, 167R, 168V, 169Q, 170S, 171V, 172A, 173L, 174K, 175L, 176I, 177C, 178D, 179L, 180E, 181D, 182K, 183I
CDD
cd00186 (TOP1Ac)

150E

domain I
131T, 132N, 133K, 134V, 135N, 136A, 137Q, 138Q, 139A, 140R, 141R, 142V, 143L, 144D, 145R, 146L, 147V, 148G, 149Y, 150E, 151I, 152S, 153P, 154F, 155L, 156W, 157K, 158L, 163T, 164S, 165A, 166G, 167R, 168V, 169Q, 170S, 171V, 172A, 173L, 174K, 175L, 176I, 177C, 178D, 179L, 180E, 181D, 182K, 183I
CDD
cd00186 (TOP1Ac)

151I

domain I
131T, 132N, 133K, 134V, 135N, 136A, 137Q, 138Q, 139A, 140R, 141R, 142V, 143L, 144D, 145R, 146L, 147V, 148G, 149Y, 150E, 151I, 152S, 153P, 154F, 155L, 156W, 157K, 158L, 163T, 164S, 165A, 166G, 167R, 168V, 169Q, 170S, 171V, 172A, 173L, 174K, 175L, 176I, 177C, 178D, 179L, 180E, 181D, 182K, 183I
CDD
cd00186 (TOP1Ac)

152S

domain I
131T, 132N, 133K, 134V, 135N, 136A, 137Q, 138Q, 139A, 140R, 141R, 142V, 143L, 144D, 145R, 146L, 147V, 148G, 149Y, 150E, 151I, 152S, 153P, 154F, 155L, 156W, 157K, 158L, 163T, 164S, 165A, 166G, 167R, 168V, 169Q, 170S, 171V, 172A, 173L, 174K, 175L, 176I, 177C, 178D, 179L, 180E, 181D, 182K, 183I
CDD
cd00186 (TOP1Ac)

153P

domain I
131T, 132N, 133K, 134V, 135N, 136A, 137Q, 138Q, 139A, 140R, 141R, 142V, 143L, 144D, 145R, 146L, 147V, 148G, 149Y, 150E, 151I, 152S, 153P, 154F, 155L, 156W, 157K, 158L, 163T, 164S, 165A, 166G, 167R, 168V, 169Q, 170S, 171V, 172A, 173L, 174K, 175L, 176I, 177C, 178D, 179L, 180E, 181D, 182K, 183I
CDD
cd00186 (TOP1Ac)

154F

domain I
131T, 132N, 133K, 134V, 135N, 136A, 137Q, 138Q, 139A, 140R, 141R, 142V, 143L, 144D, 145R, 146L, 147V, 148G, 149Y, 150E, 151I, 152S, 153P, 154F, 155L, 156W, 157K, 158L, 163T, 164S, 165A, 166G, 167R, 168V, 169Q, 170S, 171V, 172A, 173L, 174K, 175L, 176I, 177C, 178D, 179L, 180E, 181D, 182K, 183I
CDD
cd00186 (TOP1Ac)

155L

domain I
131T, 132N, 133K, 134V, 135N, 136A, 137Q, 138Q, 139A, 140R, 141R, 142V, 143L, 144D, 145R, 146L, 147V, 148G, 149Y, 150E, 151I, 152S, 153P, 154F, 155L, 156W, 157K, 158L, 163T, 164S, 165A, 166G, 167R, 168V, 169Q, 170S, 171V, 172A, 173L, 174K, 175L, 176I, 177C, 178D, 179L, 180E, 181D, 182K, 183I
CDD
cd00186 (TOP1Ac)

156W

domain I
131T, 132N, 133K, 134V, 135N, 136A, 137Q, 138Q, 139A, 140R, 141R, 142V, 143L, 144D, 145R, 146L, 147V, 148G, 149Y, 150E, 151I, 152S, 153P, 154F, 155L, 156W, 157K, 158L, 163T, 164S, 165A, 166G, 167R, 168V, 169Q, 170S, 171V, 172A, 173L, 174K, 175L, 176I, 177C, 178D, 179L, 180E, 181D, 182K, 183I
CDD
cd00186 (TOP1Ac)

157K

domain I
131T, 132N, 133K, 134V, 135N, 136A, 137Q, 138Q, 139A, 140R, 141R, 142V, 143L, 144D, 145R, 146L, 147V, 148G, 149Y, 150E, 151I, 152S, 153P, 154F, 155L, 156W, 157K, 158L, 163T, 164S, 165A, 166G, 167R, 168V, 169Q, 170S, 171V, 172A, 173L, 174K, 175L, 176I, 177C, 178D, 179L, 180E, 181D, 182K, 183I
CDD
cd00186 (TOP1Ac)

158L

domain I
131T, 132N, 133K, 134V, 135N, 136A, 137Q, 138Q, 139A, 140R, 141R, 142V, 143L, 144D, 145R, 146L, 147V, 148G, 149Y, 150E, 151I, 152S, 153P, 154F, 155L, 156W, 157K, 158L, 163T, 164S, 165A, 166G, 167R, 168V, 169Q, 170S, 171V, 172A, 173L, 174K, 175L, 176I, 177C, 178D, 179L, 180E, 181D, 182K, 183I
CDD
cd00186 (TOP1Ac)

163T

domain I
131T, 132N, 133K, 134V, 135N, 136A, 137Q, 138Q, 139A, 140R, 141R, 142V, 143L, 144D, 145R, 146L, 147V, 148G, 149Y, 150E, 151I, 152S, 153P, 154F, 155L, 156W, 157K, 158L, 163T, 164S, 165A, 166G, 167R, 168V, 169Q, 170S, 171V, 172A, 173L, 174K, 175L, 176I, 177C, 178D, 179L, 180E, 181D, 182K, 183I
CDD
cd00186 (TOP1Ac)

164S

domain I
131T, 132N, 133K, 134V, 135N, 136A, 137Q, 138Q, 139A, 140R, 141R, 142V, 143L, 144D, 145R, 146L, 147V, 148G, 149Y, 150E, 151I, 152S, 153P, 154F, 155L, 156W, 157K, 158L, 163T, 164S, 165A, 166G, 167R, 168V, 169Q, 170S, 171V, 172A, 173L, 174K, 175L, 176I, 177C, 178D, 179L, 180E, 181D, 182K, 183I
CDD
cd00186 (TOP1Ac)

165A

domain I
131T, 132N, 133K, 134V, 135N, 136A, 137Q, 138Q, 139A, 140R, 141R, 142V, 143L, 144D, 145R, 146L, 147V, 148G, 149Y, 150E, 151I, 152S, 153P, 154F, 155L, 156W, 157K, 158L, 163T, 164S, 165A, 166G, 167R, 168V, 169Q, 170S, 171V, 172A, 173L, 174K, 175L, 176I, 177C, 178D, 179L, 180E, 181D, 182K, 183I
CDD
cd00186 (TOP1Ac)

166G

domain I
131T, 132N, 133K, 134V, 135N, 136A, 137Q, 138Q, 139A, 140R, 141R, 142V, 143L, 144D, 145R, 146L, 147V, 148G, 149Y, 150E, 151I, 152S, 153P, 154F, 155L, 156W, 157K, 158L, 163T, 164S, 165A, 166G, 167R, 168V, 169Q, 170S, 171V, 172A, 173L, 174K, 175L, 176I, 177C, 178D, 179L, 180E, 181D, 182K, 183I
CDD
cd00186 (TOP1Ac)

167R

domain I
131T, 132N, 133K, 134V, 135N, 136A, 137Q, 138Q, 139A, 140R, 141R, 142V, 143L, 144D, 145R, 146L, 147V, 148G, 149Y, 150E, 151I, 152S, 153P, 154F, 155L, 156W, 157K, 158L, 163T, 164S, 165A, 166G, 167R, 168V, 169Q, 170S, 171V, 172A, 173L, 174K, 175L, 176I, 177C, 178D, 179L, 180E, 181D, 182K, 183I
CDD
cd00186 (TOP1Ac)

168V

domain I
131T, 132N, 133K, 134V, 135N, 136A, 137Q, 138Q, 139A, 140R, 141R, 142V, 143L, 144D, 145R, 146L, 147V, 148G, 149Y, 150E, 151I, 152S, 153P, 154F, 155L, 156W, 157K, 158L, 163T, 164S, 165A, 166G, 167R, 168V, 169Q, 170S, 171V, 172A, 173L, 174K, 175L, 176I, 177C, 178D, 179L, 180E, 181D, 182K, 183I
CDD
cd00186 (TOP1Ac)

169Q

domain I
131T, 132N, 133K, 134V, 135N, 136A, 137Q, 138Q, 139A, 140R, 141R, 142V, 143L, 144D, 145R, 146L, 147V, 148G, 149Y, 150E, 151I, 152S, 153P, 154F, 155L, 156W, 157K, 158L, 163T, 164S, 165A, 166G, 167R, 168V, 169Q, 170S, 171V, 172A, 173L, 174K, 175L, 176I, 177C, 178D, 179L, 180E, 181D, 182K, 183I
CDD
cd00186 (TOP1Ac)

170S

domain I
131T, 132N, 133K, 134V, 135N, 136A, 137Q, 138Q, 139A, 140R, 141R, 142V, 143L, 144D, 145R, 146L, 147V, 148G, 149Y, 150E, 151I, 152S, 153P, 154F, 155L, 156W, 157K, 158L, 163T, 164S, 165A, 166G, 167R, 168V, 169Q, 170S, 171V, 172A, 173L, 174K, 175L, 176I, 177C, 178D, 179L, 180E, 181D, 182K, 183I
CDD
cd00186 (TOP1Ac)

171V

domain I
131T, 132N, 133K, 134V, 135N, 136A, 137Q, 138Q, 139A, 140R, 141R, 142V, 143L, 144D, 145R, 146L, 147V, 148G, 149Y, 150E, 151I, 152S, 153P, 154F, 155L, 156W, 157K, 158L, 163T, 164S, 165A, 166G, 167R, 168V, 169Q, 170S, 171V, 172A, 173L, 174K, 175L, 176I, 177C, 178D, 179L, 180E, 181D, 182K, 183I
CDD
cd00186 (TOP1Ac)

172A

domain I
131T, 132N, 133K, 134V, 135N, 136A, 137Q, 138Q, 139A, 140R, 141R, 142V, 143L, 144D, 145R, 146L, 147V, 148G, 149Y, 150E, 151I, 152S, 153P, 154F, 155L, 156W, 157K, 158L, 163T, 164S, 165A, 166G, 167R, 168V, 169Q, 170S, 171V, 172A, 173L, 174K, 175L, 176I, 177C, 178D, 179L, 180E, 181D, 182K, 183I
CDD
cd00186 (TOP1Ac)

173L

domain I
131T, 132N, 133K, 134V, 135N, 136A, 137Q, 138Q, 139A, 140R, 141R, 142V, 143L, 144D, 145R, 146L, 147V, 148G, 149Y, 150E, 151I, 152S, 153P, 154F, 155L, 156W, 157K, 158L, 163T, 164S, 165A, 166G, 167R, 168V, 169Q, 170S, 171V, 172A, 173L, 174K, 175L, 176I, 177C, 178D, 179L, 180E, 181D, 182K, 183I
CDD
cd00186 (TOP1Ac)

174K

domain I
131T, 132N, 133K, 134V, 135N, 136A, 137Q, 138Q, 139A, 140R, 141R, 142V, 143L, 144D, 145R, 146L, 147V, 148G, 149Y, 150E, 151I, 152S, 153P, 154F, 155L, 156W, 157K, 158L, 163T, 164S, 165A, 166G, 167R, 168V, 169Q, 170S, 171V, 172A, 173L, 174K, 175L, 176I, 177C, 178D, 179L, 180E, 181D, 182K, 183I
CDD
cd00186 (TOP1Ac)

175L

domain I
131T, 132N, 133K, 134V, 135N, 136A, 137Q, 138Q, 139A, 140R, 141R, 142V, 143L, 144D, 145R, 146L, 147V, 148G, 149Y, 150E, 151I, 152S, 153P, 154F, 155L, 156W, 157K, 158L, 163T, 164S, 165A, 166G, 167R, 168V, 169Q, 170S, 171V, 172A, 173L, 174K, 175L, 176I, 177C, 178D, 179L, 180E, 181D, 182K, 183I
CDD
cd00186 (TOP1Ac)

176I

domain I
131T, 132N, 133K, 134V, 135N, 136A, 137Q, 138Q, 139A, 140R, 141R, 142V, 143L, 144D, 145R, 146L, 147V, 148G, 149Y, 150E, 151I, 152S, 153P, 154F, 155L, 156W, 157K, 158L, 163T, 164S, 165A, 166G, 167R, 168V, 169Q, 170S, 171V, 172A, 173L, 174K, 175L, 176I, 177C, 178D, 179L, 180E, 181D, 182K, 183I
CDD
cd00186 (TOP1Ac)

177C

domain I
131T, 132N, 133K, 134V, 135N, 136A, 137Q, 138Q, 139A, 140R, 141R, 142V, 143L, 144D, 145R, 146L, 147V, 148G, 149Y, 150E, 151I, 152S, 153P, 154F, 155L, 156W, 157K, 158L, 163T, 164S, 165A, 166G, 167R, 168V, 169Q, 170S, 171V, 172A, 173L, 174K, 175L, 176I, 177C, 178D, 179L, 180E, 181D, 182K, 183I
CDD
cd00186 (TOP1Ac)

178D

domain I
131T, 132N, 133K, 134V, 135N, 136A, 137Q, 138Q, 139A, 140R, 141R, 142V, 143L, 144D, 145R, 146L, 147V, 148G, 149Y, 150E, 151I, 152S, 153P, 154F, 155L, 156W, 157K, 158L, 163T, 164S, 165A, 166G, 167R, 168V, 169Q, 170S, 171V, 172A, 173L, 174K, 175L, 176I, 177C, 178D, 179L, 180E, 181D, 182K, 183I
CDD
cd00186 (TOP1Ac)

179L

domain I
131T, 132N, 133K, 134V, 135N, 136A, 137Q, 138Q, 139A, 140R, 141R, 142V, 143L, 144D, 145R, 146L, 147V, 148G, 149Y, 150E, 151I, 152S, 153P, 154F, 155L, 156W, 157K, 158L, 163T, 164S, 165A, 166G, 167R, 168V, 169Q, 170S, 171V, 172A, 173L, 174K, 175L, 176I, 177C, 178D, 179L, 180E, 181D, 182K, 183I
CDD
cd00186 (TOP1Ac)

180E

domain I
131T, 132N, 133K, 134V, 135N, 136A, 137Q, 138Q, 139A, 140R, 141R, 142V, 143L, 144D, 145R, 146L, 147V, 148G, 149Y, 150E, 151I, 152S, 153P, 154F, 155L, 156W, 157K, 158L, 163T, 164S, 165A, 166G, 167R, 168V, 169Q, 170S, 171V, 172A, 173L, 174K, 175L, 176I, 177C, 178D, 179L, 180E, 181D, 182K, 183I
CDD
cd00186 (TOP1Ac)

181D

domain I
131T, 132N, 133K, 134V, 135N, 136A, 137Q, 138Q, 139A, 140R, 141R, 142V, 143L, 144D, 145R, 146L, 147V, 148G, 149Y, 150E, 151I, 152S, 153P, 154F, 155L, 156W, 157K, 158L, 163T, 164S, 165A, 166G, 167R, 168V, 169Q, 170S, 171V, 172A, 173L, 174K, 175L, 176I, 177C, 178D, 179L, 180E, 181D, 182K, 183I
CDD
cd00186 (TOP1Ac)

182K

domain I
131T, 132N, 133K, 134V, 135N, 136A, 137Q, 138Q, 139A, 140R, 141R, 142V, 143L, 144D, 145R, 146L, 147V, 148G, 149Y, 150E, 151I, 152S, 153P, 154F, 155L, 156W, 157K, 158L, 163T, 164S, 165A, 166G, 167R, 168V, 169Q, 170S, 171V, 172A, 173L, 174K, 175L, 176I, 177C, 178D, 179L, 180E, 181D, 182K, 183I
CDD
cd00186 (TOP1Ac)

183I

domain I
131T, 132N, 133K, 134V, 135N, 136A, 137Q, 138Q, 139A, 140R, 141R, 142V, 143L, 144D, 145R, 146L, 147V, 148G, 149Y, 150E, 151I, 152S, 153P, 154F, 155L, 156W, 157K, 158L, 163T, 164S, 165A, 166G, 167R, 168V, 169Q, 170S, 171V, 172A, 173L, 174K, 175L, 176I, 177C, 178D, 179L, 180E, 181D, 182K, 183I
CDD
cd00186 (TOP1Ac)
DNA binding groove...

140R

DNA binding groove
140R, 141R, 144D, 148G, 152S, 277Q, 281E, 297R, 471S, 472T, 475T, 476I, 478E, 482K, 483R
CDD
cd00186 (TOP1Ac)

141R

DNA binding groove
140R, 141R, 144D, 148G, 152S, 277Q, 281E, 297R, 471S, 472T, 475T, 476I, 478E, 482K, 483R
CDD
cd00186 (TOP1Ac)

144D

DNA binding groove
140R, 141R, 144D, 148G, 152S, 277Q, 281E, 297R, 471S, 472T, 475T, 476I, 478E, 482K, 483R
CDD
cd00186 (TOP1Ac)

148G

DNA binding groove
140R, 141R, 144D, 148G, 152S, 277Q, 281E, 297R, 471S, 472T, 475T, 476I, 478E, 482K, 483R
CDD
cd00186 (TOP1Ac)

152S

DNA binding groove
140R, 141R, 144D, 148G, 152S, 277Q, 281E, 297R, 471S, 472T, 475T, 476I, 478E, 482K, 483R
CDD
cd00186 (TOP1Ac)

277Q

DNA binding groove
140R, 141R, 144D, 148G, 152S, 277Q, 281E, 297R, 471S, 472T, 475T, 476I, 478E, 482K, 483R
CDD
cd00186 (TOP1Ac)

281E

DNA binding groove
140R, 141R, 144D, 148G, 152S, 277Q, 281E, 297R, 471S, 472T, 475T, 476I, 478E, 482K, 483R
CDD
cd00186 (TOP1Ac)

297R

DNA binding groove
140R, 141R, 144D, 148G, 152S, 277Q, 281E, 297R, 471S, 472T, 475T, 476I, 478E, 482K, 483R
CDD
cd00186 (TOP1Ac)

471S

DNA binding groove
140R, 141R, 144D, 148G, 152S, 277Q, 281E, 297R, 471S, 472T, 475T, 476I, 478E, 482K, 483R
CDD
cd00186 (TOP1Ac)

472T

DNA binding groove
140R, 141R, 144D, 148G, 152S, 277Q, 281E, 297R, 471S, 472T, 475T, 476I, 478E, 482K, 483R
CDD
cd00186 (TOP1Ac)

475T

DNA binding groove
140R, 141R, 144D, 148G, 152S, 277Q, 281E, 297R, 471S, 472T, 475T, 476I, 478E, 482K, 483R
CDD
cd00186 (TOP1Ac)

476I

DNA binding groove
140R, 141R, 144D, 148G, 152S, 277Q, 281E, 297R, 471S, 472T, 475T, 476I, 478E, 482K, 483R
CDD
cd00186 (TOP1Ac)

478E

DNA binding groove
140R, 141R, 144D, 148G, 152S, 277Q, 281E, 297R, 471S, 472T, 475T, 476I, 478E, 482K, 483R
CDD
cd00186 (TOP1Ac)

482K

DNA binding groove
140R, 141R, 144D, 148G, 152S, 277Q, 281E, 297R, 471S, 472T, 475T, 476I, 478E, 482K, 483R
CDD
cd00186 (TOP1Ac)

483R

DNA binding groove
140R, 141R, 144D, 148G, 152S, 277Q, 281E, 297R, 471S, 472T, 475T, 476I, 478E, 482K, 483R
CDD
cd00186 (TOP1Ac)
phosphate binding ...

174K

phosphate binding site
174K, 178D, 507E
CDD
cd00186 (TOP1Ac)

178D

phosphate binding site
174K, 178D, 507E
CDD
cd00186 (TOP1Ac)

507E

phosphate binding site
174K, 178D, 507E
CDD
cd00186 (TOP1Ac)
domain II cd00186

188P

domain II
188P, 189E, 190K, 191Y, 192W, 193D, 194V, 232Q, 233K, 234F, 235T, 236V, 237V, 238E, 239A, 240K, 241I, 242S, 243K, 244K, 245S, 246K, 247R, 381A, 382S, 383M, 384K, 385Y, 386E, 387Q, 388F, 389E, 390V, 391V, 392C, 393E, 394R, 395E, 397V, 398Q, 399F, 400R, 401G, 402S, 403M, 404N, 405K, 406I, 407L, 408F, 409D, 410G, 411Y, 412Y, 413K, 414V, 415F, 438S, 439K, 440L, 441E, 442I, 443K, 444E, 445D, 446M, 447T, 448K
CDD
cd00186 (TOP1Ac)

189E

domain II
188P, 189E, 190K, 191Y, 192W, 193D, 194V, 232Q, 233K, 234F, 235T, 236V, 237V, 238E, 239A, 240K, 241I, 242S, 243K, 244K, 245S, 246K, 247R, 381A, 382S, 383M, 384K, 385Y, 386E, 387Q, 388F, 389E, 390V, 391V, 392C, 393E, 394R, 395E, 397V, 398Q, 399F, 400R, 401G, 402S, 403M, 404N, 405K, 406I, 407L, 408F, 409D, 410G, 411Y, 412Y, 413K, 414V, 415F, 438S, 439K, 440L, 441E, 442I, 443K, 444E, 445D, 446M, 447T, 448K
CDD
cd00186 (TOP1Ac)

190K

domain II
188P, 189E, 190K, 191Y, 192W, 193D, 194V, 232Q, 233K, 234F, 235T, 236V, 237V, 238E, 239A, 240K, 241I, 242S, 243K, 244K, 245S, 246K, 247R, 381A, 382S, 383M, 384K, 385Y, 386E, 387Q, 388F, 389E, 390V, 391V, 392C, 393E, 394R, 395E, 397V, 398Q, 399F, 400R, 401G, 402S, 403M, 404N, 405K, 406I, 407L, 408F, 409D, 410G, 411Y, 412Y, 413K, 414V, 415F, 438S, 439K, 440L, 441E, 442I, 443K, 444E, 445D, 446M, 447T, 448K
CDD
cd00186 (TOP1Ac)

191Y

domain II
188P, 189E, 190K, 191Y, 192W, 193D, 194V, 232Q, 233K, 234F, 235T, 236V, 237V, 238E, 239A, 240K, 241I, 242S, 243K, 244K, 245S, 246K, 247R, 381A, 382S, 383M, 384K, 385Y, 386E, 387Q, 388F, 389E, 390V, 391V, 392C, 393E, 394R, 395E, 397V, 398Q, 399F, 400R, 401G, 402S, 403M, 404N, 405K, 406I, 407L, 408F, 409D, 410G, 411Y, 412Y, 413K, 414V, 415F, 438S, 439K, 440L, 441E, 442I, 443K, 444E, 445D, 446M, 447T, 448K
CDD
cd00186 (TOP1Ac)

192W

domain II
188P, 189E, 190K, 191Y, 192W, 193D, 194V, 232Q, 233K, 234F, 235T, 236V, 237V, 238E, 239A, 240K, 241I, 242S, 243K, 244K, 245S, 246K, 247R, 381A, 382S, 383M, 384K, 385Y, 386E, 387Q, 388F, 389E, 390V, 391V, 392C, 393E, 394R, 395E, 397V, 398Q, 399F, 400R, 401G, 402S, 403M, 404N, 405K, 406I, 407L, 408F, 409D, 410G, 411Y, 412Y, 413K, 414V, 415F, 438S, 439K, 440L, 441E, 442I, 443K, 444E, 445D, 446M, 447T, 448K
CDD
cd00186 (TOP1Ac)

193D

domain II
188P, 189E, 190K, 191Y, 192W, 193D, 194V, 232Q, 233K, 234F, 235T, 236V, 237V, 238E, 239A, 240K, 241I, 242S, 243K, 244K, 245S, 246K, 247R, 381A, 382S, 383M, 384K, 385Y, 386E, 387Q, 388F, 389E, 390V, 391V, 392C, 393E, 394R, 395E, 397V, 398Q, 399F, 400R, 401G, 402S, 403M, 404N, 405K, 406I, 407L, 408F, 409D, 410G, 411Y, 412Y, 413K, 414V, 415F, 438S, 439K, 440L, 441E, 442I, 443K, 444E, 445D, 446M, 447T, 448K
CDD
cd00186 (TOP1Ac)

194V

domain II
188P, 189E, 190K, 191Y, 192W, 193D, 194V, 232Q, 233K, 234F, 235T, 236V, 237V, 238E, 239A, 240K, 241I, 242S, 243K, 244K, 245S, 246K, 247R, 381A, 382S, 383M, 384K, 385Y, 386E, 387Q, 388F, 389E, 390V, 391V, 392C, 393E, 394R, 395E, 397V, 398Q, 399F, 400R, 401G, 402S, 403M, 404N, 405K, 406I, 407L, 408F, 409D, 410G, 411Y, 412Y, 413K, 414V, 415F, 438S, 439K, 440L, 441E, 442I, 443K, 444E, 445D, 446M, 447T, 448K
CDD
cd00186 (TOP1Ac)

232Q

domain II
188P, 189E, 190K, 191Y, 192W, 193D, 194V, 232Q, 233K, 234F, 235T, 236V, 237V, 238E, 239A, 240K, 241I, 242S, 243K, 244K, 245S, 246K, 247R, 381A, 382S, 383M, 384K, 385Y, 386E, 387Q, 388F, 389E, 390V, 391V, 392C, 393E, 394R, 395E, 397V, 398Q, 399F, 400R, 401G, 402S, 403M, 404N, 405K, 406I, 407L, 408F, 409D, 410G, 411Y, 412Y, 413K, 414V, 415F, 438S, 439K, 440L, 441E, 442I, 443K, 444E, 445D, 446M, 447T, 448K
CDD
cd00186 (TOP1Ac)

233K

domain II
188P, 189E, 190K, 191Y, 192W, 193D, 194V, 232Q, 233K, 234F, 235T, 236V, 237V, 238E, 239A, 240K, 241I, 242S, 243K, 244K, 245S, 246K, 247R, 381A, 382S, 383M, 384K, 385Y, 386E, 387Q, 388F, 389E, 390V, 391V, 392C, 393E, 394R, 395E, 397V, 398Q, 399F, 400R, 401G, 402S, 403M, 404N, 405K, 406I, 407L, 408F, 409D, 410G, 411Y, 412Y, 413K, 414V, 415F, 438S, 439K, 440L, 441E, 442I, 443K, 444E, 445D, 446M, 447T, 448K
CDD
cd00186 (TOP1Ac)

234F

domain II
188P, 189E, 190K, 191Y, 192W, 193D, 194V, 232Q, 233K, 234F, 235T, 236V, 237V, 238E, 239A, 240K, 241I, 242S, 243K, 244K, 245S, 246K, 247R, 381A, 382S, 383M, 384K, 385Y, 386E, 387Q, 388F, 389E, 390V, 391V, 392C, 393E, 394R, 395E, 397V, 398Q, 399F, 400R, 401G, 402S, 403M, 404N, 405K, 406I, 407L, 408F, 409D, 410G, 411Y, 412Y, 413K, 414V, 415F, 438S, 439K, 440L, 441E, 442I, 443K, 444E, 445D, 446M, 447T, 448K
CDD
cd00186 (TOP1Ac)

235T

domain II
188P, 189E, 190K, 191Y, 192W, 193D, 194V, 232Q, 233K, 234F, 235T, 236V, 237V, 238E, 239A, 240K, 241I, 242S, 243K, 244K, 245S, 246K, 247R, 381A, 382S, 383M, 384K, 385Y, 386E, 387Q, 388F, 389E, 390V, 391V, 392C, 393E, 394R, 395E, 397V, 398Q, 399F, 400R, 401G, 402S, 403M, 404N, 405K, 406I, 407L, 408F, 409D, 410G, 411Y, 412Y, 413K, 414V, 415F, 438S, 439K, 440L, 441E, 442I, 443K, 444E, 445D, 446M, 447T, 448K
CDD
cd00186 (TOP1Ac)

236V

domain II
188P, 189E, 190K, 191Y, 192W, 193D, 194V, 232Q, 233K, 234F, 235T, 236V, 237V, 238E, 239A, 240K, 241I, 242S, 243K, 244K, 245S, 246K, 247R, 381A, 382S, 383M, 384K, 385Y, 386E, 387Q, 388F, 389E, 390V, 391V, 392C, 393E, 394R, 395E, 397V, 398Q, 399F, 400R, 401G, 402S, 403M, 404N, 405K, 406I, 407L, 408F, 409D, 410G, 411Y, 412Y, 413K, 414V, 415F, 438S, 439K, 440L, 441E, 442I, 443K, 444E, 445D, 446M, 447T, 448K
CDD
cd00186 (TOP1Ac)

237V

domain II
188P, 189E, 190K, 191Y, 192W, 193D, 194V, 232Q, 233K, 234F, 235T, 236V, 237V, 238E, 239A, 240K, 241I, 242S, 243K, 244K, 245S, 246K, 247R, 381A, 382S, 383M, 384K, 385Y, 386E, 387Q, 388F, 389E, 390V, 391V, 392C, 393E, 394R, 395E, 397V, 398Q, 399F, 400R, 401G, 402S, 403M, 404N, 405K, 406I, 407L, 408F, 409D, 410G, 411Y, 412Y, 413K, 414V, 415F, 438S, 439K, 440L, 441E, 442I, 443K, 444E, 445D, 446M, 447T, 448K
CDD
cd00186 (TOP1Ac)

238E

domain II
188P, 189E, 190K, 191Y, 192W, 193D, 194V, 232Q, 233K, 234F, 235T, 236V, 237V, 238E, 239A, 240K, 241I, 242S, 243K, 244K, 245S, 246K, 247R, 381A, 382S, 383M, 384K, 385Y, 386E, 387Q, 388F, 389E, 390V, 391V, 392C, 393E, 394R, 395E, 397V, 398Q, 399F, 400R, 401G, 402S, 403M, 404N, 405K, 406I, 407L, 408F, 409D, 410G, 411Y, 412Y, 413K, 414V, 415F, 438S, 439K, 440L, 441E, 442I, 443K, 444E, 445D, 446M, 447T, 448K
CDD
cd00186 (TOP1Ac)

239A

domain II
188P, 189E, 190K, 191Y, 192W, 193D, 194V, 232Q, 233K, 234F, 235T, 236V, 237V, 238E, 239A, 240K, 241I, 242S, 243K, 244K, 245S, 246K, 247R, 381A, 382S, 383M, 384K, 385Y, 386E, 387Q, 388F, 389E, 390V, 391V, 392C, 393E, 394R, 395E, 397V, 398Q, 399F, 400R, 401G, 402S, 403M, 404N, 405K, 406I, 407L, 408F, 409D, 410G, 411Y, 412Y, 413K, 414V, 415F, 438S, 439K, 440L, 441E, 442I, 443K, 444E, 445D, 446M, 447T, 448K
CDD
cd00186 (TOP1Ac)

240K

domain II
188P, 189E, 190K, 191Y, 192W, 193D, 194V, 232Q, 233K, 234F, 235T, 236V, 237V, 238E, 239A, 240K, 241I, 242S, 243K, 244K, 245S, 246K, 247R, 381A, 382S, 383M, 384K, 385Y, 386E, 387Q, 388F, 389E, 390V, 391V, 392C, 393E, 394R, 395E, 397V, 398Q, 399F, 400R, 401G, 402S, 403M, 404N, 405K, 406I, 407L, 408F, 409D, 410G, 411Y, 412Y, 413K, 414V, 415F, 438S, 439K, 440L, 441E, 442I, 443K, 444E, 445D, 446M, 447T, 448K
CDD
cd00186 (TOP1Ac)

241I

domain II
188P, 189E, 190K, 191Y, 192W, 193D, 194V, 232Q, 233K, 234F, 235T, 236V, 237V, 238E, 239A, 240K, 241I, 242S, 243K, 244K, 245S, 246K, 247R, 381A, 382S, 383M, 384K, 385Y, 386E, 387Q, 388F, 389E, 390V, 391V, 392C, 393E, 394R, 395E, 397V, 398Q, 399F, 400R, 401G, 402S, 403M, 404N, 405K, 406I, 407L, 408F, 409D, 410G, 411Y, 412Y, 413K, 414V, 415F, 438S, 439K, 440L, 441E, 442I, 443K, 444E, 445D, 446M, 447T, 448K
CDD
cd00186 (TOP1Ac)

242S

domain II
188P, 189E, 190K, 191Y, 192W, 193D, 194V, 232Q, 233K, 234F, 235T, 236V, 237V, 238E, 239A, 240K, 241I, 242S, 243K, 244K, 245S, 246K, 247R, 381A, 382S, 383M, 384K, 385Y, 386E, 387Q, 388F, 389E, 390V, 391V, 392C, 393E, 394R, 395E, 397V, 398Q, 399F, 400R, 401G, 402S, 403M, 404N, 405K, 406I, 407L, 408F, 409D, 410G, 411Y, 412Y, 413K, 414V, 415F, 438S, 439K, 440L, 441E, 442I, 443K, 444E, 445D, 446M, 447T, 448K
CDD
cd00186 (TOP1Ac)

243K

domain II
188P, 189E, 190K, 191Y, 192W, 193D, 194V, 232Q, 233K, 234F, 235T, 236V, 237V, 238E, 239A, 240K, 241I, 242S, 243K, 244K, 245S, 246K, 247R, 381A, 382S, 383M, 384K, 385Y, 386E, 387Q, 388F, 389E, 390V, 391V, 392C, 393E, 394R, 395E, 397V, 398Q, 399F, 400R, 401G, 402S, 403M, 404N, 405K, 406I, 407L, 408F, 409D, 410G, 411Y, 412Y, 413K, 414V, 415F, 438S, 439K, 440L, 441E, 442I, 443K, 444E, 445D, 446M, 447T, 448K
CDD
cd00186 (TOP1Ac)

244K

domain II
188P, 189E, 190K, 191Y, 192W, 193D, 194V, 232Q, 233K, 234F, 235T, 236V, 237V, 238E, 239A, 240K, 241I, 242S, 243K, 244K, 245S, 246K, 247R, 381A, 382S, 383M, 384K, 385Y, 386E, 387Q, 388F, 389E, 390V, 391V, 392C, 393E, 394R, 395E, 397V, 398Q, 399F, 400R, 401G, 402S, 403M, 404N, 405K, 406I, 407L, 408F, 409D, 410G, 411Y, 412Y, 413K, 414V, 415F, 438S, 439K, 440L, 441E, 442I, 443K, 444E, 445D, 446M, 447T, 448K
CDD
cd00186 (TOP1Ac)

245S

domain II
188P, 189E, 190K, 191Y, 192W, 193D, 194V, 232Q, 233K, 234F, 235T, 236V, 237V, 238E, 239A, 240K, 241I, 242S, 243K, 244K, 245S, 246K, 247R, 381A, 382S, 383M, 384K, 385Y, 386E, 387Q, 388F, 389E, 390V, 391V, 392C, 393E, 394R, 395E, 397V, 398Q, 399F, 400R, 401G, 402S, 403M, 404N, 405K, 406I, 407L, 408F, 409D, 410G, 411Y, 412Y, 413K, 414V, 415F, 438S, 439K, 440L, 441E, 442I, 443K, 444E, 445D, 446M, 447T, 448K
CDD
cd00186 (TOP1Ac)

246K

domain II
188P, 189E, 190K, 191Y, 192W, 193D, 194V, 232Q, 233K, 234F, 235T, 236V, 237V, 238E, 239A, 240K, 241I, 242S, 243K, 244K, 245S, 246K, 247R, 381A, 382S, 383M, 384K, 385Y, 386E, 387Q, 388F, 389E, 390V, 391V, 392C, 393E, 394R, 395E, 397V, 398Q, 399F, 400R, 401G, 402S, 403M, 404N, 405K, 406I, 407L, 408F, 409D, 410G, 411Y, 412Y, 413K, 414V, 415F, 438S, 439K, 440L, 441E, 442I, 443K, 444E, 445D, 446M, 447T, 448K
CDD
cd00186 (TOP1Ac)

247R

domain II
188P, 189E, 190K, 191Y, 192W, 193D, 194V, 232Q, 233K, 234F, 235T, 236V, 237V, 238E, 239A, 240K, 241I, 242S, 243K, 244K, 245S, 246K, 247R, 381A, 382S, 383M, 384K, 385Y, 386E, 387Q, 388F, 389E, 390V, 391V, 392C, 393E, 394R, 395E, 397V, 398Q, 399F, 400R, 401G, 402S, 403M, 404N, 405K, 406I, 407L, 408F, 409D, 410G, 411Y, 412Y, 413K, 414V, 415F, 438S, 439K, 440L, 441E, 442I, 443K, 444E, 445D, 446M, 447T, 448K
CDD
cd00186 (TOP1Ac)

381A

domain II
188P, 189E, 190K, 191Y, 192W, 193D, 194V, 232Q, 233K, 234F, 235T, 236V, 237V, 238E, 239A, 240K, 241I, 242S, 243K, 244K, 245S, 246K, 247R, 381A, 382S, 383M, 384K, 385Y, 386E, 387Q, 388F, 389E, 390V, 391V, 392C, 393E, 394R, 395E, 397V, 398Q, 399F, 400R, 401G, 402S, 403M, 404N, 405K, 406I, 407L, 408F, 409D, 410G, 411Y, 412Y, 413K, 414V, 415F, 438S, 439K, 440L, 441E, 442I, 443K, 444E, 445D, 446M, 447T, 448K
CDD
cd00186 (TOP1Ac)

382S

domain II
188P, 189E, 190K, 191Y, 192W, 193D, 194V, 232Q, 233K, 234F, 235T, 236V, 237V, 238E, 239A, 240K, 241I, 242S, 243K, 244K, 245S, 246K, 247R, 381A, 382S, 383M, 384K, 385Y, 386E, 387Q, 388F, 389E, 390V, 391V, 392C, 393E, 394R, 395E, 397V, 398Q, 399F, 400R, 401G, 402S, 403M, 404N, 405K, 406I, 407L, 408F, 409D, 410G, 411Y, 412Y, 413K, 414V, 415F, 438S, 439K, 440L, 441E, 442I, 443K, 444E, 445D, 446M, 447T, 448K
CDD
cd00186 (TOP1Ac)

383M

domain II
188P, 189E, 190K, 191Y, 192W, 193D, 194V, 232Q, 233K, 234F, 235T, 236V, 237V, 238E, 239A, 240K, 241I, 242S, 243K, 244K, 245S, 246K, 247R, 381A, 382S, 383M, 384K, 385Y, 386E, 387Q, 388F, 389E, 390V, 391V, 392C, 393E, 394R, 395E, 397V, 398Q, 399F, 400R, 401G, 402S, 403M, 404N, 405K, 406I, 407L, 408F, 409D, 410G, 411Y, 412Y, 413K, 414V, 415F, 438S, 439K, 440L, 441E, 442I, 443K, 444E, 445D, 446M, 447T, 448K
CDD
cd00186 (TOP1Ac)

384K

domain II
188P, 189E, 190K, 191Y, 192W, 193D, 194V, 232Q, 233K, 234F, 235T, 236V, 237V, 238E, 239A, 240K, 241I, 242S, 243K, 244K, 245S, 246K, 247R, 381A, 382S, 383M, 384K, 385Y, 386E, 387Q, 388F, 389E, 390V, 391V, 392C, 393E, 394R, 395E, 397V, 398Q, 399F, 400R, 401G, 402S, 403M, 404N, 405K, 406I, 407L, 408F, 409D, 410G, 411Y, 412Y, 413K, 414V, 415F, 438S, 439K, 440L, 441E, 442I, 443K, 444E, 445D, 446M, 447T, 448K
CDD
cd00186 (TOP1Ac)

385Y

domain II
188P, 189E, 190K, 191Y, 192W, 193D, 194V, 232Q, 233K, 234F, 235T, 236V, 237V, 238E, 239A, 240K, 241I, 242S, 243K, 244K, 245S, 246K, 247R, 381A, 382S, 383M, 384K, 385Y, 386E, 387Q, 388F, 389E, 390V, 391V, 392C, 393E, 394R, 395E, 397V, 398Q, 399F, 400R, 401G, 402S, 403M, 404N, 405K, 406I, 407L, 408F, 409D, 410G, 411Y, 412Y, 413K, 414V, 415F, 438S, 439K, 440L, 441E, 442I, 443K, 444E, 445D, 446M, 447T, 448K
CDD
cd00186 (TOP1Ac)

386E

domain II
188P, 189E, 190K, 191Y, 192W, 193D, 194V, 232Q, 233K, 234F, 235T, 236V, 237V, 238E, 239A, 240K, 241I, 242S, 243K, 244K, 245S, 246K, 247R, 381A, 382S, 383M, 384K, 385Y, 386E, 387Q, 388F, 389E, 390V, 391V, 392C, 393E, 394R, 395E, 397V, 398Q, 399F, 400R, 401G, 402S, 403M, 404N, 405K, 406I, 407L, 408F, 409D, 410G, 411Y, 412Y, 413K, 414V, 415F, 438S, 439K, 440L, 441E, 442I, 443K, 444E, 445D, 446M, 447T, 448K
CDD
cd00186 (TOP1Ac)

387Q

domain II
188P, 189E, 190K, 191Y, 192W, 193D, 194V, 232Q, 233K, 234F, 235T, 236V, 237V, 238E, 239A, 240K, 241I, 242S, 243K, 244K, 245S, 246K, 247R, 381A, 382S, 383M, 384K, 385Y, 386E, 387Q, 388F, 389E, 390V, 391V, 392C, 393E, 394R, 395E, 397V, 398Q, 399F, 400R, 401G, 402S, 403M, 404N, 405K, 406I, 407L, 408F, 409D, 410G, 411Y, 412Y, 413K, 414V, 415F, 438S, 439K, 440L, 441E, 442I, 443K, 444E, 445D, 446M, 447T, 448K
CDD
cd00186 (TOP1Ac)

388F

domain II
188P, 189E, 190K, 191Y, 192W, 193D, 194V, 232Q, 233K, 234F, 235T, 236V, 237V, 238E, 239A, 240K, 241I, 242S, 243K, 244K, 245S, 246K, 247R, 381A, 382S, 383M, 384K, 385Y, 386E, 387Q, 388F, 389E, 390V, 391V, 392C, 393E, 394R, 395E, 397V, 398Q, 399F, 400R, 401G, 402S, 403M, 404N, 405K, 406I, 407L, 408F, 409D, 410G, 411Y, 412Y, 413K, 414V, 415F, 438S, 439K, 440L, 441E, 442I, 443K, 444E, 445D, 446M, 447T, 448K
CDD
cd00186 (TOP1Ac)

389E

domain II
188P, 189E, 190K, 191Y, 192W, 193D, 194V, 232Q, 233K, 234F, 235T, 236V, 237V, 238E, 239A, 240K, 241I, 242S, 243K, 244K, 245S, 246K, 247R, 381A, 382S, 383M, 384K, 385Y, 386E, 387Q, 388F, 389E, 390V, 391V, 392C, 393E, 394R, 395E, 397V, 398Q, 399F, 400R, 401G, 402S, 403M, 404N, 405K, 406I, 407L, 408F, 409D, 410G, 411Y, 412Y, 413K, 414V, 415F, 438S, 439K, 440L, 441E, 442I, 443K, 444E, 445D, 446M, 447T, 448K
CDD
cd00186 (TOP1Ac)

390V

domain II
188P, 189E, 190K, 191Y, 192W, 193D, 194V, 232Q, 233K, 234F, 235T, 236V, 237V, 238E, 239A, 240K, 241I, 242S, 243K, 244K, 245S, 246K, 247R, 381A, 382S, 383M, 384K, 385Y, 386E, 387Q, 388F, 389E, 390V, 391V, 392C, 393E, 394R, 395E, 397V, 398Q, 399F, 400R, 401G, 402S, 403M, 404N, 405K, 406I, 407L, 408F, 409D, 410G, 411Y, 412Y, 413K, 414V, 415F, 438S, 439K, 440L, 441E, 442I, 443K, 444E, 445D, 446M, 447T, 448K
CDD
cd00186 (TOP1Ac)

391V

domain II
188P, 189E, 190K, 191Y, 192W, 193D, 194V, 232Q, 233K, 234F, 235T, 236V, 237V, 238E, 239A, 240K, 241I, 242S, 243K, 244K, 245S, 246K, 247R, 381A, 382S, 383M, 384K, 385Y, 386E, 387Q, 388F, 389E, 390V, 391V, 392C, 393E, 394R, 395E, 397V, 398Q, 399F, 400R, 401G, 402S, 403M, 404N, 405K, 406I, 407L, 408F, 409D, 410G, 411Y, 412Y, 413K, 414V, 415F, 438S, 439K, 440L, 441E, 442I, 443K, 444E, 445D, 446M, 447T, 448K
CDD
cd00186 (TOP1Ac)

392C

domain II
188P, 189E, 190K, 191Y, 192W, 193D, 194V, 232Q, 233K, 234F, 235T, 236V, 237V, 238E, 239A, 240K, 241I, 242S, 243K, 244K, 245S, 246K, 247R, 381A, 382S, 383M, 384K, 385Y, 386E, 387Q, 388F, 389E, 390V, 391V, 392C, 393E, 394R, 395E, 397V, 398Q, 399F, 400R, 401G, 402S, 403M, 404N, 405K, 406I, 407L, 408F, 409D, 410G, 411Y, 412Y, 413K, 414V, 415F, 438S, 439K, 440L, 441E, 442I, 443K, 444E, 445D, 446M, 447T, 448K
CDD
cd00186 (TOP1Ac)

393E

domain II
188P, 189E, 190K, 191Y, 192W, 193D, 194V, 232Q, 233K, 234F, 235T, 236V, 237V, 238E, 239A, 240K, 241I, 242S, 243K, 244K, 245S, 246K, 247R, 381A, 382S, 383M, 384K, 385Y, 386E, 387Q, 388F, 389E, 390V, 391V, 392C, 393E, 394R, 395E, 397V, 398Q, 399F, 400R, 401G, 402S, 403M, 404N, 405K, 406I, 407L, 408F, 409D, 410G, 411Y, 412Y, 413K, 414V, 415F, 438S, 439K, 440L, 441E, 442I, 443K, 444E, 445D, 446M, 447T, 448K
CDD
cd00186 (TOP1Ac)

394R

domain II
188P, 189E, 190K, 191Y, 192W, 193D, 194V, 232Q, 233K, 234F, 235T, 236V, 237V, 238E, 239A, 240K, 241I, 242S, 243K, 244K, 245S, 246K, 247R, 381A, 382S, 383M, 384K, 385Y, 386E, 387Q, 388F, 389E, 390V, 391V, 392C, 393E, 394R, 395E, 397V, 398Q, 399F, 400R, 401G, 402S, 403M, 404N, 405K, 406I, 407L, 408F, 409D, 410G, 411Y, 412Y, 413K, 414V, 415F, 438S, 439K, 440L, 441E, 442I, 443K, 444E, 445D, 446M, 447T, 448K
CDD
cd00186 (TOP1Ac)

395E

domain II
188P, 189E, 190K, 191Y, 192W, 193D, 194V, 232Q, 233K, 234F, 235T, 236V, 237V, 238E, 239A, 240K, 241I, 242S, 243K, 244K, 245S, 246K, 247R, 381A, 382S, 383M, 384K, 385Y, 386E, 387Q, 388F, 389E, 390V, 391V, 392C, 393E, 394R, 395E, 397V, 398Q, 399F, 400R, 401G, 402S, 403M, 404N, 405K, 406I, 407L, 408F, 409D, 410G, 411Y, 412Y, 413K, 414V, 415F, 438S, 439K, 440L, 441E, 442I, 443K, 444E, 445D, 446M, 447T, 448K
CDD
cd00186 (TOP1Ac)

397V

domain II
188P, 189E, 190K, 191Y, 192W, 193D, 194V, 232Q, 233K, 234F, 235T, 236V, 237V, 238E, 239A, 240K, 241I, 242S, 243K, 244K, 245S, 246K, 247R, 381A, 382S, 383M, 384K, 385Y, 386E, 387Q, 388F, 389E, 390V, 391V, 392C, 393E, 394R, 395E, 397V, 398Q, 399F, 400R, 401G, 402S, 403M, 404N, 405K, 406I, 407L, 408F, 409D, 410G, 411Y, 412Y, 413K, 414V, 415F, 438S, 439K, 440L, 441E, 442I, 443K, 444E, 445D, 446M, 447T, 448K
CDD
cd00186 (TOP1Ac)

398Q

domain II
188P, 189E, 190K, 191Y, 192W, 193D, 194V, 232Q, 233K, 234F, 235T, 236V, 237V, 238E, 239A, 240K, 241I, 242S, 243K, 244K, 245S, 246K, 247R, 381A, 382S, 383M, 384K, 385Y, 386E, 387Q, 388F, 389E, 390V, 391V, 392C, 393E, 394R, 395E, 397V, 398Q, 399F, 400R, 401G, 402S, 403M, 404N, 405K, 406I, 407L, 408F, 409D, 410G, 411Y, 412Y, 413K, 414V, 415F, 438S, 439K, 440L, 441E, 442I, 443K, 444E, 445D, 446M, 447T, 448K
CDD
cd00186 (TOP1Ac)

399F

domain II
188P, 189E, 190K, 191Y, 192W, 193D, 194V, 232Q, 233K, 234F, 235T, 236V, 237V, 238E, 239A, 240K, 241I, 242S, 243K, 244K, 245S, 246K, 247R, 381A, 382S, 383M, 384K, 385Y, 386E, 387Q, 388F, 389E, 390V, 391V, 392C, 393E, 394R, 395E, 397V, 398Q, 399F, 400R, 401G, 402S, 403M, 404N, 405K, 406I, 407L, 408F, 409D, 410G, 411Y, 412Y, 413K, 414V, 415F, 438S, 439K, 440L, 441E, 442I, 443K, 444E, 445D, 446M, 447T, 448K
CDD
cd00186 (TOP1Ac)

400R

domain II
188P, 189E, 190K, 191Y, 192W, 193D, 194V, 232Q, 233K, 234F, 235T, 236V, 237V, 238E, 239A, 240K, 241I, 242S, 243K, 244K, 245S, 246K, 247R, 381A, 382S, 383M, 384K, 385Y, 386E, 387Q, 388F, 389E, 390V, 391V, 392C, 393E, 394R, 395E, 397V, 398Q, 399F, 400R, 401G, 402S, 403M, 404N, 405K, 406I, 407L, 408F, 409D, 410G, 411Y, 412Y, 413K, 414V, 415F, 438S, 439K, 440L, 441E, 442I, 443K, 444E, 445D, 446M, 447T, 448K
CDD
cd00186 (TOP1Ac)

401G

domain II
188P, 189E, 190K, 191Y, 192W, 193D, 194V, 232Q, 233K, 234F, 235T, 236V, 237V, 238E, 239A, 240K, 241I, 242S, 243K, 244K, 245S, 246K, 247R, 381A, 382S, 383M, 384K, 385Y, 386E, 387Q, 388F, 389E, 390V, 391V, 392C, 393E, 394R, 395E, 397V, 398Q, 399F, 400R, 401G, 402S, 403M, 404N, 405K, 406I, 407L, 408F, 409D, 410G, 411Y, 412Y, 413K, 414V, 415F, 438S, 439K, 440L, 441E, 442I, 443K, 444E, 445D, 446M, 447T, 448K
CDD
cd00186 (TOP1Ac)

402S

domain II
188P, 189E, 190K, 191Y, 192W, 193D, 194V, 232Q, 233K, 234F, 235T, 236V, 237V, 238E, 239A, 240K, 241I, 242S, 243K, 244K, 245S, 246K, 247R, 381A, 382S, 383M, 384K, 385Y, 386E, 387Q, 388F, 389E, 390V, 391V, 392C, 393E, 394R, 395E, 397V, 398Q, 399F, 400R, 401G, 402S, 403M, 404N, 405K, 406I, 407L, 408F, 409D, 410G, 411Y, 412Y, 413K, 414V, 415F, 438S, 439K, 440L, 441E, 442I, 443K, 444E, 445D, 446M, 447T, 448K
CDD
cd00186 (TOP1Ac)

403M

domain II
188P, 189E, 190K, 191Y, 192W, 193D, 194V, 232Q, 233K, 234F, 235T, 236V, 237V, 238E, 239A, 240K, 241I, 242S, 243K, 244K, 245S, 246K, 247R, 381A, 382S, 383M, 384K, 385Y, 386E, 387Q, 388F, 389E, 390V, 391V, 392C, 393E, 394R, 395E, 397V, 398Q, 399F, 400R, 401G, 402S, 403M, 404N, 405K, 406I, 407L, 408F, 409D, 410G, 411Y, 412Y, 413K, 414V, 415F, 438S, 439K, 440L, 441E, 442I, 443K, 444E, 445D, 446M, 447T, 448K
CDD
cd00186 (TOP1Ac)

404N

domain II
188P, 189E, 190K, 191Y, 192W, 193D, 194V, 232Q, 233K, 234F, 235T, 236V, 237V, 238E, 239A, 240K, 241I, 242S, 243K, 244K, 245S, 246K, 247R, 381A, 382S, 383M, 384K, 385Y, 386E, 387Q, 388F, 389E, 390V, 391V, 392C, 393E, 394R, 395E, 397V, 398Q, 399F, 400R, 401G, 402S, 403M, 404N, 405K, 406I, 407L, 408F, 409D, 410G, 411Y, 412Y, 413K, 414V, 415F, 438S, 439K, 440L, 441E, 442I, 443K, 444E, 445D, 446M, 447T, 448K
CDD
cd00186 (TOP1Ac)

405K

domain II
188P, 189E, 190K, 191Y, 192W, 193D, 194V, 232Q, 233K, 234F, 235T, 236V, 237V, 238E, 239A, 240K, 241I, 242S, 243K, 244K, 245S, 246K, 247R, 381A, 382S, 383M, 384K, 385Y, 386E, 387Q, 388F, 389E, 390V, 391V, 392C, 393E, 394R, 395E, 397V, 398Q, 399F, 400R, 401G, 402S, 403M, 404N, 405K, 406I, 407L, 408F, 409D, 410G, 411Y, 412Y, 413K, 414V, 415F, 438S, 439K, 440L, 441E, 442I, 443K, 444E, 445D, 446M, 447T, 448K
CDD
cd00186 (TOP1Ac)

406I

domain II
188P, 189E, 190K, 191Y, 192W, 193D, 194V, 232Q, 233K, 234F, 235T, 236V, 237V, 238E, 239A, 240K, 241I, 242S, 243K, 244K, 245S, 246K, 247R, 381A, 382S, 383M, 384K, 385Y, 386E, 387Q, 388F, 389E, 390V, 391V, 392C, 393E, 394R, 395E, 397V, 398Q, 399F, 400R, 401G, 402S, 403M, 404N, 405K, 406I, 407L, 408F, 409D, 410G, 411Y, 412Y, 413K, 414V, 415F, 438S, 439K, 440L, 441E, 442I, 443K, 444E, 445D, 446M, 447T, 448K
CDD
cd00186 (TOP1Ac)

407L

domain II
188P, 189E, 190K, 191Y, 192W, 193D, 194V, 232Q, 233K, 234F, 235T, 236V, 237V, 238E, 239A, 240K, 241I, 242S, 243K, 244K, 245S, 246K, 247R, 381A, 382S, 383M, 384K, 385Y, 386E, 387Q, 388F, 389E, 390V, 391V, 392C, 393E, 394R, 395E, 397V, 398Q, 399F, 400R, 401G, 402S, 403M, 404N, 405K, 406I, 407L, 408F, 409D, 410G, 411Y, 412Y, 413K, 414V, 415F, 438S, 439K, 440L, 441E, 442I, 443K, 444E, 445D, 446M, 447T, 448K
CDD
cd00186 (TOP1Ac)

408F

domain II
188P, 189E, 190K, 191Y, 192W, 193D, 194V, 232Q, 233K, 234F, 235T, 236V, 237V, 238E, 239A, 240K, 241I, 242S, 243K, 244K, 245S, 246K, 247R, 381A, 382S, 383M, 384K, 385Y, 386E, 387Q, 388F, 389E, 390V, 391V, 392C, 393E, 394R, 395E, 397V, 398Q, 399F, 400R, 401G, 402S, 403M, 404N, 405K, 406I, 407L, 408F, 409D, 410G, 411Y, 412Y, 413K, 414V, 415F, 438S, 439K, 440L, 441E, 442I, 443K, 444E, 445D, 446M, 447T, 448K
CDD
cd00186 (TOP1Ac)

409D

domain II
188P, 189E, 190K, 191Y, 192W, 193D, 194V, 232Q, 233K, 234F, 235T, 236V, 237V, 238E, 239A, 240K, 241I, 242S, 243K, 244K, 245S, 246K, 247R, 381A, 382S, 383M, 384K, 385Y, 386E, 387Q, 388F, 389E, 390V, 391V, 392C, 393E, 394R, 395E, 397V, 398Q, 399F, 400R, 401G, 402S, 403M, 404N, 405K, 406I, 407L, 408F, 409D, 410G, 411Y, 412Y, 413K, 414V, 415F, 438S, 439K, 440L, 441E, 442I, 443K, 444E, 445D, 446M, 447T, 448K
CDD
cd00186 (TOP1Ac)

410G

domain II
188P, 189E, 190K, 191Y, 192W, 193D, 194V, 232Q, 233K, 234F, 235T, 236V, 237V, 238E, 239A, 240K, 241I, 242S, 243K, 244K, 245S, 246K, 247R, 381A, 382S, 383M, 384K, 385Y, 386E, 387Q, 388F, 389E, 390V, 391V, 392C, 393E, 394R, 395E, 397V, 398Q, 399F, 400R, 401G, 402S, 403M, 404N, 405K, 406I, 407L, 408F, 409D, 410G, 411Y, 412Y, 413K, 414V, 415F, 438S, 439K, 440L, 441E, 442I, 443K, 444E, 445D, 446M, 447T, 448K
CDD
cd00186 (TOP1Ac)

411Y

domain II
188P, 189E, 190K, 191Y, 192W, 193D, 194V, 232Q, 233K, 234F, 235T, 236V, 237V, 238E, 239A, 240K, 241I, 242S, 243K, 244K, 245S, 246K, 247R, 381A, 382S, 383M, 384K, 385Y, 386E, 387Q, 388F, 389E, 390V, 391V, 392C, 393E, 394R, 395E, 397V, 398Q, 399F, 400R, 401G, 402S, 403M, 404N, 405K, 406I, 407L, 408F, 409D, 410G, 411Y, 412Y, 413K, 414V, 415F, 438S, 439K, 440L, 441E, 442I, 443K, 444E, 445D, 446M, 447T, 448K
CDD
cd00186 (TOP1Ac)

412Y

domain II
188P, 189E, 190K, 191Y, 192W, 193D, 194V, 232Q, 233K, 234F, 235T, 236V, 237V, 238E, 239A, 240K, 241I, 242S, 243K, 244K, 245S, 246K, 247R, 381A, 382S, 383M, 384K, 385Y, 386E, 387Q, 388F, 389E, 390V, 391V, 392C, 393E, 394R, 395E, 397V, 398Q, 399F, 400R, 401G, 402S, 403M, 404N, 405K, 406I, 407L, 408F, 409D, 410G, 411Y, 412Y, 413K, 414V, 415F, 438S, 439K, 440L, 441E, 442I, 443K, 444E, 445D, 446M, 447T, 448K
CDD
cd00186 (TOP1Ac)

413K

domain II
188P, 189E, 190K, 191Y, 192W, 193D, 194V, 232Q, 233K, 234F, 235T, 236V, 237V, 238E, 239A, 240K, 241I, 242S, 243K, 244K, 245S, 246K, 247R, 381A, 382S, 383M, 384K, 385Y, 386E, 387Q, 388F, 389E, 390V, 391V, 392C, 393E, 394R, 395E, 397V, 398Q, 399F, 400R, 401G, 402S, 403M, 404N, 405K, 406I, 407L, 408F, 409D, 410G, 411Y, 412Y, 413K, 414V, 415F, 438S, 439K, 440L, 441E, 442I, 443K, 444E, 445D, 446M, 447T, 448K
CDD
cd00186 (TOP1Ac)

414V

domain II
188P, 189E, 190K, 191Y, 192W, 193D, 194V, 232Q, 233K, 234F, 235T, 236V, 237V, 238E, 239A, 240K, 241I, 242S, 243K, 244K, 245S, 246K, 247R, 381A, 382S, 383M, 384K, 385Y, 386E, 387Q, 388F, 389E, 390V, 391V, 392C, 393E, 394R, 395E, 397V, 398Q, 399F, 400R, 401G, 402S, 403M, 404N, 405K, 406I, 407L, 408F, 409D, 410G, 411Y, 412Y, 413K, 414V, 415F, 438S, 439K, 440L, 441E, 442I, 443K, 444E, 445D, 446M, 447T, 448K
CDD
cd00186 (TOP1Ac)

415F

domain II
188P, 189E, 190K, 191Y, 192W, 193D, 194V, 232Q, 233K, 234F, 235T, 236V, 237V, 238E, 239A, 240K, 241I, 242S, 243K, 244K, 245S, 246K, 247R, 381A, 382S, 383M, 384K, 385Y, 386E, 387Q, 388F, 389E, 390V, 391V, 392C, 393E, 394R, 395E, 397V, 398Q, 399F, 400R, 401G, 402S, 403M, 404N, 405K, 406I, 407L, 408F, 409D, 410G, 411Y, 412Y, 413K, 414V, 415F, 438S, 439K, 440L, 441E, 442I, 443K, 444E, 445D, 446M, 447T, 448K
CDD
cd00186 (TOP1Ac)

438S

domain II
188P, 189E, 190K, 191Y, 192W, 193D, 194V, 232Q, 233K, 234F, 235T, 236V, 237V, 238E, 239A, 240K, 241I, 242S, 243K, 244K, 245S, 246K, 247R, 381A, 382S, 383M, 384K, 385Y, 386E, 387Q, 388F, 389E, 390V, 391V, 392C, 393E, 394R, 395E, 397V, 398Q, 399F, 400R, 401G, 402S, 403M, 404N, 405K, 406I, 407L, 408F, 409D, 410G, 411Y, 412Y, 413K, 414V, 415F, 438S, 439K, 440L, 441E, 442I, 443K, 444E, 445D, 446M, 447T, 448K
CDD
cd00186 (TOP1Ac)

439K

domain II
188P, 189E, 190K, 191Y, 192W, 193D, 194V, 232Q, 233K, 234F, 235T, 236V, 237V, 238E, 239A, 240K, 241I, 242S, 243K, 244K, 245S, 246K, 247R, 381A, 382S, 383M, 384K, 385Y, 386E, 387Q, 388F, 389E, 390V, 391V, 392C, 393E, 394R, 395E, 397V, 398Q, 399F, 400R, 401G, 402S, 403M, 404N, 405K, 406I, 407L, 408F, 409D, 410G, 411Y, 412Y, 413K, 414V, 415F, 438S, 439K, 440L, 441E, 442I, 443K, 444E, 445D, 446M, 447T, 448K
CDD
cd00186 (TOP1Ac)

440L

domain II
188P, 189E, 190K, 191Y, 192W, 193D, 194V, 232Q, 233K, 234F, 235T, 236V, 237V, 238E, 239A, 240K, 241I, 242S, 243K, 244K, 245S, 246K, 247R, 381A, 382S, 383M, 384K, 385Y, 386E, 387Q, 388F, 389E, 390V, 391V, 392C, 393E, 394R, 395E, 397V, 398Q, 399F, 400R, 401G, 402S, 403M, 404N, 405K, 406I, 407L, 408F, 409D, 410G, 411Y, 412Y, 413K, 414V, 415F, 438S, 439K, 440L, 441E, 442I, 443K, 444E, 445D, 446M, 447T, 448K
CDD
cd00186 (TOP1Ac)

441E

domain II
188P, 189E, 190K, 191Y, 192W, 193D, 194V, 232Q, 233K, 234F, 235T, 236V, 237V, 238E, 239A, 240K, 241I, 242S, 243K, 244K, 245S, 246K, 247R, 381A, 382S, 383M, 384K, 385Y, 386E, 387Q, 388F, 389E, 390V, 391V, 392C, 393E, 394R, 395E, 397V, 398Q, 399F, 400R, 401G, 402S, 403M, 404N, 405K, 406I, 407L, 408F, 409D, 410G, 411Y, 412Y, 413K, 414V, 415F, 438S, 439K, 440L, 441E, 442I, 443K, 444E, 445D, 446M, 447T, 448K
CDD
cd00186 (TOP1Ac)

442I

domain II
188P, 189E, 190K, 191Y, 192W, 193D, 194V, 232Q, 233K, 234F, 235T, 236V, 237V, 238E, 239A, 240K, 241I, 242S, 243K, 244K, 245S, 246K, 247R, 381A, 382S, 383M, 384K, 385Y, 386E, 387Q, 388F, 389E, 390V, 391V, 392C, 393E, 394R, 395E, 397V, 398Q, 399F, 400R, 401G, 402S, 403M, 404N, 405K, 406I, 407L, 408F, 409D, 410G, 411Y, 412Y, 413K, 414V, 415F, 438S, 439K, 440L, 441E, 442I, 443K, 444E, 445D, 446M, 447T, 448K
CDD
cd00186 (TOP1Ac)

443K

domain II
188P, 189E, 190K, 191Y, 192W, 193D, 194V, 232Q, 233K, 234F, 235T, 236V, 237V, 238E, 239A, 240K, 241I, 242S, 243K, 244K, 245S, 246K, 247R, 381A, 382S, 383M, 384K, 385Y, 386E, 387Q, 388F, 389E, 390V, 391V, 392C, 393E, 394R, 395E, 397V, 398Q, 399F, 400R, 401G, 402S, 403M, 404N, 405K, 406I, 407L, 408F, 409D, 410G, 411Y, 412Y, 413K, 414V, 415F, 438S, 439K, 440L, 441E, 442I, 443K, 444E, 445D, 446M, 447T, 448K
CDD
cd00186 (TOP1Ac)

444E

domain II
188P, 189E, 190K, 191Y, 192W, 193D, 194V, 232Q, 233K, 234F, 235T, 236V, 237V, 238E, 239A, 240K, 241I, 242S, 243K, 244K, 245S, 246K, 247R, 381A, 382S, 383M, 384K, 385Y, 386E, 387Q, 388F, 389E, 390V, 391V, 392C, 393E, 394R, 395E, 397V, 398Q, 399F, 400R, 401G, 402S, 403M, 404N, 405K, 406I, 407L, 408F, 409D, 410G, 411Y, 412Y, 413K, 414V, 415F, 438S, 439K, 440L, 441E, 442I, 443K, 444E, 445D, 446M, 447T, 448K
CDD
cd00186 (TOP1Ac)

445D

domain II
188P, 189E, 190K, 191Y, 192W, 193D, 194V, 232Q, 233K, 234F, 235T, 236V, 237V, 238E, 239A, 240K, 241I, 242S, 243K, 244K, 245S, 246K, 247R, 381A, 382S, 383M, 384K, 385Y, 386E, 387Q, 388F, 389E, 390V, 391V, 392C, 393E, 394R, 395E, 397V, 398Q, 399F, 400R, 401G, 402S, 403M, 404N, 405K, 406I, 407L, 408F, 409D, 410G, 411Y, 412Y, 413K, 414V, 415F, 438S, 439K, 440L, 441E, 442I, 443K, 444E, 445D, 446M, 447T, 448K
CDD
cd00186 (TOP1Ac)

446M

domain II
188P, 189E, 190K, 191Y, 192W, 193D, 194V, 232Q, 233K, 234F, 235T, 236V, 237V, 238E, 239A, 240K, 241I, 242S, 243K, 244K, 245S, 246K, 247R, 381A, 382S, 383M, 384K, 385Y, 386E, 387Q, 388F, 389E, 390V, 391V, 392C, 393E, 394R, 395E, 397V, 398Q, 399F, 400R, 401G, 402S, 403M, 404N, 405K, 406I, 407L, 408F, 409D, 410G, 411Y, 412Y, 413K, 414V, 415F, 438S, 439K, 440L, 441E, 442I, 443K, 444E, 445D, 446M, 447T, 448K
CDD
cd00186 (TOP1Ac)

447T

domain II
188P, 189E, 190K, 191Y, 192W, 193D, 194V, 232Q, 233K, 234F, 235T, 236V, 237V, 238E, 239A, 240K, 241I, 242S, 243K, 244K, 245S, 246K, 247R, 381A, 382S, 383M, 384K, 385Y, 386E, 387Q, 388F, 389E, 390V, 391V, 392C, 393E, 394R, 395E, 397V, 398Q, 399F, 400R, 401G, 402S, 403M, 404N, 405K, 406I, 407L, 408F, 409D, 410G, 411Y, 412Y, 413K, 414V, 415F, 438S, 439K, 440L, 441E, 442I, 443K, 444E, 445D, 446M, 447T, 448K
CDD
cd00186 (TOP1Ac)

448K

domain II
188P, 189E, 190K, 191Y, 192W, 193D, 194V, 232Q, 233K, 234F, 235T, 236V, 237V, 238E, 239A, 240K, 241I, 242S, 243K, 244K, 245S, 246K, 247R, 381A, 382S, 383M, 384K, 385Y, 386E, 387Q, 388F, 389E, 390V, 391V, 392C, 393E, 394R, 395E, 397V, 398Q, 399F, 400R, 401G, 402S, 403M, 404N, 405K, 406I, 407L, 408F, 409D, 410G, 411Y, 412Y, 413K, 414V, 415F, 438S, 439K, 440L, 441E, 442I, 443K, 444E, 445D, 446M, 447T, 448K
CDD
cd00186 (TOP1Ac)
domain III cd00186

248P

domain III
248P, 249P, 250L, 251A, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261S, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271R, 272T, 273M, 274M, 275L, 276A, 277Q, 278K, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305Q, 306E, 307A, 308K, 309E, 310M, 311A, 312K, 313S, 314Y, 315I, 316T, 317E, 318T, 319F, 340A, 341H, 342E, 343A, 344I, 345R, 346P, 347T, 348D, 360L, 361E, 362K, 363D, 364Q, 365W, 366K, 367L, 368Y, 369K, 370L, 371I, 372W, 373E, 374R, 375F, 376L, 377I, 378S, 379E, 380L
CDD
cd00186 (TOP1Ac)

249P

domain III
248P, 249P, 250L, 251A, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261S, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271R, 272T, 273M, 274M, 275L, 276A, 277Q, 278K, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305Q, 306E, 307A, 308K, 309E, 310M, 311A, 312K, 313S, 314Y, 315I, 316T, 317E, 318T, 319F, 340A, 341H, 342E, 343A, 344I, 345R, 346P, 347T, 348D, 360L, 361E, 362K, 363D, 364Q, 365W, 366K, 367L, 368Y, 369K, 370L, 371I, 372W, 373E, 374R, 375F, 376L, 377I, 378S, 379E, 380L
CDD
cd00186 (TOP1Ac)

250L

domain III
248P, 249P, 250L, 251A, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261S, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271R, 272T, 273M, 274M, 275L, 276A, 277Q, 278K, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305Q, 306E, 307A, 308K, 309E, 310M, 311A, 312K, 313S, 314Y, 315I, 316T, 317E, 318T, 319F, 340A, 341H, 342E, 343A, 344I, 345R, 346P, 347T, 348D, 360L, 361E, 362K, 363D, 364Q, 365W, 366K, 367L, 368Y, 369K, 370L, 371I, 372W, 373E, 374R, 375F, 376L, 377I, 378S, 379E, 380L
CDD
cd00186 (TOP1Ac)

251A

domain III
248P, 249P, 250L, 251A, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261S, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271R, 272T, 273M, 274M, 275L, 276A, 277Q, 278K, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305Q, 306E, 307A, 308K, 309E, 310M, 311A, 312K, 313S, 314Y, 315I, 316T, 317E, 318T, 319F, 340A, 341H, 342E, 343A, 344I, 345R, 346P, 347T, 348D, 360L, 361E, 362K, 363D, 364Q, 365W, 366K, 367L, 368Y, 369K, 370L, 371I, 372W, 373E, 374R, 375F, 376L, 377I, 378S, 379E, 380L
CDD
cd00186 (TOP1Ac)

252L

domain III
248P, 249P, 250L, 251A, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261S, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271R, 272T, 273M, 274M, 275L, 276A, 277Q, 278K, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305Q, 306E, 307A, 308K, 309E, 310M, 311A, 312K, 313S, 314Y, 315I, 316T, 317E, 318T, 319F, 340A, 341H, 342E, 343A, 344I, 345R, 346P, 347T, 348D, 360L, 361E, 362K, 363D, 364Q, 365W, 366K, 367L, 368Y, 369K, 370L, 371I, 372W, 373E, 374R, 375F, 376L, 377I, 378S, 379E, 380L
CDD
cd00186 (TOP1Ac)

253K

domain III
248P, 249P, 250L, 251A, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261S, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271R, 272T, 273M, 274M, 275L, 276A, 277Q, 278K, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305Q, 306E, 307A, 308K, 309E, 310M, 311A, 312K, 313S, 314Y, 315I, 316T, 317E, 318T, 319F, 340A, 341H, 342E, 343A, 344I, 345R, 346P, 347T, 348D, 360L, 361E, 362K, 363D, 364Q, 365W, 366K, 367L, 368Y, 369K, 370L, 371I, 372W, 373E, 374R, 375F, 376L, 377I, 378S, 379E, 380L
CDD
cd00186 (TOP1Ac)

254T

domain III
248P, 249P, 250L, 251A, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261S, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271R, 272T, 273M, 274M, 275L, 276A, 277Q, 278K, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305Q, 306E, 307A, 308K, 309E, 310M, 311A, 312K, 313S, 314Y, 315I, 316T, 317E, 318T, 319F, 340A, 341H, 342E, 343A, 344I, 345R, 346P, 347T, 348D, 360L, 361E, 362K, 363D, 364Q, 365W, 366K, 367L, 368Y, 369K, 370L, 371I, 372W, 373E, 374R, 375F, 376L, 377I, 378S, 379E, 380L
CDD
cd00186 (TOP1Ac)

256T

domain III
248P, 249P, 250L, 251A, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261S, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271R, 272T, 273M, 274M, 275L, 276A, 277Q, 278K, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305Q, 306E, 307A, 308K, 309E, 310M, 311A, 312K, 313S, 314Y, 315I, 316T, 317E, 318T, 319F, 340A, 341H, 342E, 343A, 344I, 345R, 346P, 347T, 348D, 360L, 361E, 362K, 363D, 364Q, 365W, 366K, 367L, 368Y, 369K, 370L, 371I, 372W, 373E, 374R, 375F, 376L, 377I, 378S, 379E, 380L
CDD
cd00186 (TOP1Ac)

257L

domain III
248P, 249P, 250L, 251A, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261S, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271R, 272T, 273M, 274M, 275L, 276A, 277Q, 278K, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305Q, 306E, 307A, 308K, 309E, 310M, 311A, 312K, 313S, 314Y, 315I, 316T, 317E, 318T, 319F, 340A, 341H, 342E, 343A, 344I, 345R, 346P, 347T, 348D, 360L, 361E, 362K, 363D, 364Q, 365W, 366K, 367L, 368Y, 369K, 370L, 371I, 372W, 373E, 374R, 375F, 376L, 377I, 378S, 379E, 380L
CDD
cd00186 (TOP1Ac)

258Q

domain III
248P, 249P, 250L, 251A, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261S, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271R, 272T, 273M, 274M, 275L, 276A, 277Q, 278K, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305Q, 306E, 307A, 308K, 309E, 310M, 311A, 312K, 313S, 314Y, 315I, 316T, 317E, 318T, 319F, 340A, 341H, 342E, 343A, 344I, 345R, 346P, 347T, 348D, 360L, 361E, 362K, 363D, 364Q, 365W, 366K, 367L, 368Y, 369K, 370L, 371I, 372W, 373E, 374R, 375F, 376L, 377I, 378S, 379E, 380L
CDD
cd00186 (TOP1Ac)

259Q

domain III
248P, 249P, 250L, 251A, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261S, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271R, 272T, 273M, 274M, 275L, 276A, 277Q, 278K, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305Q, 306E, 307A, 308K, 309E, 310M, 311A, 312K, 313S, 314Y, 315I, 316T, 317E, 318T, 319F, 340A, 341H, 342E, 343A, 344I, 345R, 346P, 347T, 348D, 360L, 361E, 362K, 363D, 364Q, 365W, 366K, 367L, 368Y, 369K, 370L, 371I, 372W, 373E, 374R, 375F, 376L, 377I, 378S, 379E, 380L
CDD
cd00186 (TOP1Ac)

260L

domain III
248P, 249P, 250L, 251A, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261S, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271R, 272T, 273M, 274M, 275L, 276A, 277Q, 278K, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305Q, 306E, 307A, 308K, 309E, 310M, 311A, 312K, 313S, 314Y, 315I, 316T, 317E, 318T, 319F, 340A, 341H, 342E, 343A, 344I, 345R, 346P, 347T, 348D, 360L, 361E, 362K, 363D, 364Q, 365W, 366K, 367L, 368Y, 369K, 370L, 371I, 372W, 373E, 374R, 375F, 376L, 377I, 378S, 379E, 380L
CDD
cd00186 (TOP1Ac)

261S

domain III
248P, 249P, 250L, 251A, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261S, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271R, 272T, 273M, 274M, 275L, 276A, 277Q, 278K, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305Q, 306E, 307A, 308K, 309E, 310M, 311A, 312K, 313S, 314Y, 315I, 316T, 317E, 318T, 319F, 340A, 341H, 342E, 343A, 344I, 345R, 346P, 347T, 348D, 360L, 361E, 362K, 363D, 364Q, 365W, 366K, 367L, 368Y, 369K, 370L, 371I, 372W, 373E, 374R, 375F, 376L, 377I, 378S, 379E, 380L
CDD
cd00186 (TOP1Ac)

262S

domain III
248P, 249P, 250L, 251A, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261S, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271R, 272T, 273M, 274M, 275L, 276A, 277Q, 278K, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305Q, 306E, 307A, 308K, 309E, 310M, 311A, 312K, 313S, 314Y, 315I, 316T, 317E, 318T, 319F, 340A, 341H, 342E, 343A, 344I, 345R, 346P, 347T, 348D, 360L, 361E, 362K, 363D, 364Q, 365W, 366K, 367L, 368Y, 369K, 370L, 371I, 372W, 373E, 374R, 375F, 376L, 377I, 378S, 379E, 380L
CDD
cd00186 (TOP1Ac)

263S

domain III
248P, 249P, 250L, 251A, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261S, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271R, 272T, 273M, 274M, 275L, 276A, 277Q, 278K, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305Q, 306E, 307A, 308K, 309E, 310M, 311A, 312K, 313S, 314Y, 315I, 316T, 317E, 318T, 319F, 340A, 341H, 342E, 343A, 344I, 345R, 346P, 347T, 348D, 360L, 361E, 362K, 363D, 364Q, 365W, 366K, 367L, 368Y, 369K, 370L, 371I, 372W, 373E, 374R, 375F, 376L, 377I, 378S, 379E, 380L
CDD
cd00186 (TOP1Ac)

264Y

domain III
248P, 249P, 250L, 251A, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261S, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271R, 272T, 273M, 274M, 275L, 276A, 277Q, 278K, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305Q, 306E, 307A, 308K, 309E, 310M, 311A, 312K, 313S, 314Y, 315I, 316T, 317E, 318T, 319F, 340A, 341H, 342E, 343A, 344I, 345R, 346P, 347T, 348D, 360L, 361E, 362K, 363D, 364Q, 365W, 366K, 367L, 368Y, 369K, 370L, 371I, 372W, 373E, 374R, 375F, 376L, 377I, 378S, 379E, 380L
CDD
cd00186 (TOP1Ac)

265L

domain III
248P, 249P, 250L, 251A, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261S, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271R, 272T, 273M, 274M, 275L, 276A, 277Q, 278K, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305Q, 306E, 307A, 308K, 309E, 310M, 311A, 312K, 313S, 314Y, 315I, 316T, 317E, 318T, 319F, 340A, 341H, 342E, 343A, 344I, 345R, 346P, 347T, 348D, 360L, 361E, 362K, 363D, 364Q, 365W, 366K, 367L, 368Y, 369K, 370L, 371I, 372W, 373E, 374R, 375F, 376L, 377I, 378S, 379E, 380L
CDD
cd00186 (TOP1Ac)

266G

domain III
248P, 249P, 250L, 251A, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261S, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271R, 272T, 273M, 274M, 275L, 276A, 277Q, 278K, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305Q, 306E, 307A, 308K, 309E, 310M, 311A, 312K, 313S, 314Y, 315I, 316T, 317E, 318T, 319F, 340A, 341H, 342E, 343A, 344I, 345R, 346P, 347T, 348D, 360L, 361E, 362K, 363D, 364Q, 365W, 366K, 367L, 368Y, 369K, 370L, 371I, 372W, 373E, 374R, 375F, 376L, 377I, 378S, 379E, 380L
CDD
cd00186 (TOP1Ac)

267F

domain III
248P, 249P, 250L, 251A, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261S, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271R, 272T, 273M, 274M, 275L, 276A, 277Q, 278K, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305Q, 306E, 307A, 308K, 309E, 310M, 311A, 312K, 313S, 314Y, 315I, 316T, 317E, 318T, 319F, 340A, 341H, 342E, 343A, 344I, 345R, 346P, 347T, 348D, 360L, 361E, 362K, 363D, 364Q, 365W, 366K, 367L, 368Y, 369K, 370L, 371I, 372W, 373E, 374R, 375F, 376L, 377I, 378S, 379E, 380L
CDD
cd00186 (TOP1Ac)

268S

domain III
248P, 249P, 250L, 251A, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261S, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271R, 272T, 273M, 274M, 275L, 276A, 277Q, 278K, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305Q, 306E, 307A, 308K, 309E, 310M, 311A, 312K, 313S, 314Y, 315I, 316T, 317E, 318T, 319F, 340A, 341H, 342E, 343A, 344I, 345R, 346P, 347T, 348D, 360L, 361E, 362K, 363D, 364Q, 365W, 366K, 367L, 368Y, 369K, 370L, 371I, 372W, 373E, 374R, 375F, 376L, 377I, 378S, 379E, 380L
CDD
cd00186 (TOP1Ac)

269A

domain III
248P, 249P, 250L, 251A, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261S, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271R, 272T, 273M, 274M, 275L, 276A, 277Q, 278K, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305Q, 306E, 307A, 308K, 309E, 310M, 311A, 312K, 313S, 314Y, 315I, 316T, 317E, 318T, 319F, 340A, 341H, 342E, 343A, 344I, 345R, 346P, 347T, 348D, 360L, 361E, 362K, 363D, 364Q, 365W, 366K, 367L, 368Y, 369K, 370L, 371I, 372W, 373E, 374R, 375F, 376L, 377I, 378S, 379E, 380L
CDD
cd00186 (TOP1Ac)

270S

domain III
248P, 249P, 250L, 251A, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261S, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271R, 272T, 273M, 274M, 275L, 276A, 277Q, 278K, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305Q, 306E, 307A, 308K, 309E, 310M, 311A, 312K, 313S, 314Y, 315I, 316T, 317E, 318T, 319F, 340A, 341H, 342E, 343A, 344I, 345R, 346P, 347T, 348D, 360L, 361E, 362K, 363D, 364Q, 365W, 366K, 367L, 368Y, 369K, 370L, 371I, 372W, 373E, 374R, 375F, 376L, 377I, 378S, 379E, 380L
CDD
cd00186 (TOP1Ac)

271R

domain III
248P, 249P, 250L, 251A, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261S, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271R, 272T, 273M, 274M, 275L, 276A, 277Q, 278K, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305Q, 306E, 307A, 308K, 309E, 310M, 311A, 312K, 313S, 314Y, 315I, 316T, 317E, 318T, 319F, 340A, 341H, 342E, 343A, 344I, 345R, 346P, 347T, 348D, 360L, 361E, 362K, 363D, 364Q, 365W, 366K, 367L, 368Y, 369K, 370L, 371I, 372W, 373E, 374R, 375F, 376L, 377I, 378S, 379E, 380L
CDD
cd00186 (TOP1Ac)

272T

domain III
248P, 249P, 250L, 251A, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261S, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271R, 272T, 273M, 274M, 275L, 276A, 277Q, 278K, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305Q, 306E, 307A, 308K, 309E, 310M, 311A, 312K, 313S, 314Y, 315I, 316T, 317E, 318T, 319F, 340A, 341H, 342E, 343A, 344I, 345R, 346P, 347T, 348D, 360L, 361E, 362K, 363D, 364Q, 365W, 366K, 367L, 368Y, 369K, 370L, 371I, 372W, 373E, 374R, 375F, 376L, 377I, 378S, 379E, 380L
CDD
cd00186 (TOP1Ac)

273M

domain III
248P, 249P, 250L, 251A, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261S, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271R, 272T, 273M, 274M, 275L, 276A, 277Q, 278K, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305Q, 306E, 307A, 308K, 309E, 310M, 311A, 312K, 313S, 314Y, 315I, 316T, 317E, 318T, 319F, 340A, 341H, 342E, 343A, 344I, 345R, 346P, 347T, 348D, 360L, 361E, 362K, 363D, 364Q, 365W, 366K, 367L, 368Y, 369K, 370L, 371I, 372W, 373E, 374R, 375F, 376L, 377I, 378S, 379E, 380L
CDD
cd00186 (TOP1Ac)

274M

domain III
248P, 249P, 250L, 251A, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261S, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271R, 272T, 273M, 274M, 275L, 276A, 277Q, 278K, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305Q, 306E, 307A, 308K, 309E, 310M, 311A, 312K, 313S, 314Y, 315I, 316T, 317E, 318T, 319F, 340A, 341H, 342E, 343A, 344I, 345R, 346P, 347T, 348D, 360L, 361E, 362K, 363D, 364Q, 365W, 366K, 367L, 368Y, 369K, 370L, 371I, 372W, 373E, 374R, 375F, 376L, 377I, 378S, 379E, 380L
CDD
cd00186 (TOP1Ac)

275L

domain III
248P, 249P, 250L, 251A, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261S, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271R, 272T, 273M, 274M, 275L, 276A, 277Q, 278K, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305Q, 306E, 307A, 308K, 309E, 310M, 311A, 312K, 313S, 314Y, 315I, 316T, 317E, 318T, 319F, 340A, 341H, 342E, 343A, 344I, 345R, 346P, 347T, 348D, 360L, 361E, 362K, 363D, 364Q, 365W, 366K, 367L, 368Y, 369K, 370L, 371I, 372W, 373E, 374R, 375F, 376L, 377I, 378S, 379E, 380L
CDD
cd00186 (TOP1Ac)

276A

domain III
248P, 249P, 250L, 251A, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261S, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271R, 272T, 273M, 274M, 275L, 276A, 277Q, 278K, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305Q, 306E, 307A, 308K, 309E, 310M, 311A, 312K, 313S, 314Y, 315I, 316T, 317E, 318T, 319F, 340A, 341H, 342E, 343A, 344I, 345R, 346P, 347T, 348D, 360L, 361E, 362K, 363D, 364Q, 365W, 366K, 367L, 368Y, 369K, 370L, 371I, 372W, 373E, 374R, 375F, 376L, 377I, 378S, 379E, 380L
CDD
cd00186 (TOP1Ac)

277Q

domain III
248P, 249P, 250L, 251A, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261S, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271R, 272T, 273M, 274M, 275L, 276A, 277Q, 278K, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305Q, 306E, 307A, 308K, 309E, 310M, 311A, 312K, 313S, 314Y, 315I, 316T, 317E, 318T, 319F, 340A, 341H, 342E, 343A, 344I, 345R, 346P, 347T, 348D, 360L, 361E, 362K, 363D, 364Q, 365W, 366K, 367L, 368Y, 369K, 370L, 371I, 372W, 373E, 374R, 375F, 376L, 377I, 378S, 379E, 380L
CDD
cd00186 (TOP1Ac)

278K

domain III
248P, 249P, 250L, 251A, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261S, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271R, 272T, 273M, 274M, 275L, 276A, 277Q, 278K, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305Q, 306E, 307A, 308K, 309E, 310M, 311A, 312K, 313S, 314Y, 315I, 316T, 317E, 318T, 319F, 340A, 341H, 342E, 343A, 344I, 345R, 346P, 347T, 348D, 360L, 361E, 362K, 363D, 364Q, 365W, 366K, 367L, 368Y, 369K, 370L, 371I, 372W, 373E, 374R, 375F, 376L, 377I, 378S, 379E, 380L
CDD
cd00186 (TOP1Ac)

279L

domain III
248P, 249P, 250L, 251A, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261S, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271R, 272T, 273M, 274M, 275L, 276A, 277Q, 278K, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305Q, 306E, 307A, 308K, 309E, 310M, 311A, 312K, 313S, 314Y, 315I, 316T, 317E, 318T, 319F, 340A, 341H, 342E, 343A, 344I, 345R, 346P, 347T, 348D, 360L, 361E, 362K, 363D, 364Q, 365W, 366K, 367L, 368Y, 369K, 370L, 371I, 372W, 373E, 374R, 375F, 376L, 377I, 378S, 379E, 380L
CDD
cd00186 (TOP1Ac)

280Y

domain III
248P, 249P, 250L, 251A, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261S, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271R, 272T, 273M, 274M, 275L, 276A, 277Q, 278K, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305Q, 306E, 307A, 308K, 309E, 310M, 311A, 312K, 313S, 314Y, 315I, 316T, 317E, 318T, 319F, 340A, 341H, 342E, 343A, 344I, 345R, 346P, 347T, 348D, 360L, 361E, 362K, 363D, 364Q, 365W, 366K, 367L, 368Y, 369K, 370L, 371I, 372W, 373E, 374R, 375F, 376L, 377I, 378S, 379E, 380L
CDD
cd00186 (TOP1Ac)

281E

domain III
248P, 249P, 250L, 251A, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261S, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271R, 272T, 273M, 274M, 275L, 276A, 277Q, 278K, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305Q, 306E, 307A, 308K, 309E, 310M, 311A, 312K, 313S, 314Y, 315I, 316T, 317E, 318T, 319F, 340A, 341H, 342E, 343A, 344I, 345R, 346P, 347T, 348D, 360L, 361E, 362K, 363D, 364Q, 365W, 366K, 367L, 368Y, 369K, 370L, 371I, 372W, 373E, 374R, 375F, 376L, 377I, 378S, 379E, 380L
CDD
cd00186 (TOP1Ac)

290K

domain III
248P, 249P, 250L, 251A, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261S, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271R, 272T, 273M, 274M, 275L, 276A, 277Q, 278K, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305Q, 306E, 307A, 308K, 309E, 310M, 311A, 312K, 313S, 314Y, 315I, 316T, 317E, 318T, 319F, 340A, 341H, 342E, 343A, 344I, 345R, 346P, 347T, 348D, 360L, 361E, 362K, 363D, 364Q, 365W, 366K, 367L, 368Y, 369K, 370L, 371I, 372W, 373E, 374R, 375F, 376L, 377I, 378S, 379E, 380L
CDD
cd00186 (TOP1Ac)

291G

domain III
248P, 249P, 250L, 251A, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261S, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271R, 272T, 273M, 274M, 275L, 276A, 277Q, 278K, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305Q, 306E, 307A, 308K, 309E, 310M, 311A, 312K, 313S, 314Y, 315I, 316T, 317E, 318T, 319F, 340A, 341H, 342E, 343A, 344I, 345R, 346P, 347T, 348D, 360L, 361E, 362K, 363D, 364Q, 365W, 366K, 367L, 368Y, 369K, 370L, 371I, 372W, 373E, 374R, 375F, 376L, 377I, 378S, 379E, 380L
CDD
cd00186 (TOP1Ac)

292L

domain III
248P, 249P, 250L, 251A, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261S, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271R, 272T, 273M, 274M, 275L, 276A, 277Q, 278K, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305Q, 306E, 307A, 308K, 309E, 310M, 311A, 312K, 313S, 314Y, 315I, 316T, 317E, 318T, 319F, 340A, 341H, 342E, 343A, 344I, 345R, 346P, 347T, 348D, 360L, 361E, 362K, 363D, 364Q, 365W, 366K, 367L, 368Y, 369K, 370L, 371I, 372W, 373E, 374R, 375F, 376L, 377I, 378S, 379E, 380L
CDD
cd00186 (TOP1Ac)

293I

domain III
248P, 249P, 250L, 251A, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261S, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271R, 272T, 273M, 274M, 275L, 276A, 277Q, 278K, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305Q, 306E, 307A, 308K, 309E, 310M, 311A, 312K, 313S, 314Y, 315I, 316T, 317E, 318T, 319F, 340A, 341H, 342E, 343A, 344I, 345R, 346P, 347T, 348D, 360L, 361E, 362K, 363D, 364Q, 365W, 366K, 367L, 368Y, 369K, 370L, 371I, 372W, 373E, 374R, 375F, 376L, 377I, 378S, 379E, 380L
CDD
cd00186 (TOP1Ac)

294T

domain III
248P, 249P, 250L, 251A, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261S, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271R, 272T, 273M, 274M, 275L, 276A, 277Q, 278K, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305Q, 306E, 307A, 308K, 309E, 310M, 311A, 312K, 313S, 314Y, 315I, 316T, 317E, 318T, 319F, 340A, 341H, 342E, 343A, 344I, 345R, 346P, 347T, 348D, 360L, 361E, 362K, 363D, 364Q, 365W, 366K, 367L, 368Y, 369K, 370L, 371I, 372W, 373E, 374R, 375F, 376L, 377I, 378S, 379E, 380L
CDD
cd00186 (TOP1Ac)

295Y

domain III
248P, 249P, 250L, 251A, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261S, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271R, 272T, 273M, 274M, 275L, 276A, 277Q, 278K, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305Q, 306E, 307A, 308K, 309E, 310M, 311A, 312K, 313S, 314Y, 315I, 316T, 317E, 318T, 319F, 340A, 341H, 342E, 343A, 344I, 345R, 346P, 347T, 348D, 360L, 361E, 362K, 363D, 364Q, 365W, 366K, 367L, 368Y, 369K, 370L, 371I, 372W, 373E, 374R, 375F, 376L, 377I, 378S, 379E, 380L
CDD
cd00186 (TOP1Ac)

296M

domain III
248P, 249P, 250L, 251A, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261S, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271R, 272T, 273M, 274M, 275L, 276A, 277Q, 278K, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305Q, 306E, 307A, 308K, 309E, 310M, 311A, 312K, 313S, 314Y, 315I, 316T, 317E, 318T, 319F, 340A, 341H, 342E, 343A, 344I, 345R, 346P, 347T, 348D, 360L, 361E, 362K, 363D, 364Q, 365W, 366K, 367L, 368Y, 369K, 370L, 371I, 372W, 373E, 374R, 375F, 376L, 377I, 378S, 379E, 380L
CDD
cd00186 (TOP1Ac)

297R

domain III
248P, 249P, 250L, 251A, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261S, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271R, 272T, 273M, 274M, 275L, 276A, 277Q, 278K, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305Q, 306E, 307A, 308K, 309E, 310M, 311A, 312K, 313S, 314Y, 315I, 316T, 317E, 318T, 319F, 340A, 341H, 342E, 343A, 344I, 345R, 346P, 347T, 348D, 360L, 361E, 362K, 363D, 364Q, 365W, 366K, 367L, 368Y, 369K, 370L, 371I, 372W, 373E, 374R, 375F, 376L, 377I, 378S, 379E, 380L
CDD
cd00186 (TOP1Ac)

298T

domain III
248P, 249P, 250L, 251A, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261S, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271R, 272T, 273M, 274M, 275L, 276A, 277Q, 278K, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305Q, 306E, 307A, 308K, 309E, 310M, 311A, 312K, 313S, 314Y, 315I, 316T, 317E, 318T, 319F, 340A, 341H, 342E, 343A, 344I, 345R, 346P, 347T, 348D, 360L, 361E, 362K, 363D, 364Q, 365W, 366K, 367L, 368Y, 369K, 370L, 371I, 372W, 373E, 374R, 375F, 376L, 377I, 378S, 379E, 380L
CDD
cd00186 (TOP1Ac)

299D

domain III
248P, 249P, 250L, 251A, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261S, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271R, 272T, 273M, 274M, 275L, 276A, 277Q, 278K, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305Q, 306E, 307A, 308K, 309E, 310M, 311A, 312K, 313S, 314Y, 315I, 316T, 317E, 318T, 319F, 340A, 341H, 342E, 343A, 344I, 345R, 346P, 347T, 348D, 360L, 361E, 362K, 363D, 364Q, 365W, 366K, 367L, 368Y, 369K, 370L, 371I, 372W, 373E, 374R, 375F, 376L, 377I, 378S, 379E, 380L
CDD
cd00186 (TOP1Ac)

300S

domain III
248P, 249P, 250L, 251A, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261S, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271R, 272T, 273M, 274M, 275L, 276A, 277Q, 278K, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305Q, 306E, 307A, 308K, 309E, 310M, 311A, 312K, 313S, 314Y, 315I, 316T, 317E, 318T, 319F, 340A, 341H, 342E, 343A, 344I, 345R, 346P, 347T, 348D, 360L, 361E, 362K, 363D, 364Q, 365W, 366K, 367L, 368Y, 369K, 370L, 371I, 372W, 373E, 374R, 375F, 376L, 377I, 378S, 379E, 380L
CDD
cd00186 (TOP1Ac)

301T

domain III
248P, 249P, 250L, 251A, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261S, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271R, 272T, 273M, 274M, 275L, 276A, 277Q, 278K, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305Q, 306E, 307A, 308K, 309E, 310M, 311A, 312K, 313S, 314Y, 315I, 316T, 317E, 318T, 319F, 340A, 341H, 342E, 343A, 344I, 345R, 346P, 347T, 348D, 360L, 361E, 362K, 363D, 364Q, 365W, 366K, 367L, 368Y, 369K, 370L, 371I, 372W, 373E, 374R, 375F, 376L, 377I, 378S, 379E, 380L
CDD
cd00186 (TOP1Ac)

302R

domain III
248P, 249P, 250L, 251A, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261S, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271R, 272T, 273M, 274M, 275L, 276A, 277Q, 278K, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305Q, 306E, 307A, 308K, 309E, 310M, 311A, 312K, 313S, 314Y, 315I, 316T, 317E, 318T, 319F, 340A, 341H, 342E, 343A, 344I, 345R, 346P, 347T, 348D, 360L, 361E, 362K, 363D, 364Q, 365W, 366K, 367L, 368Y, 369K, 370L, 371I, 372W, 373E, 374R, 375F, 376L, 377I, 378S, 379E, 380L
CDD
cd00186 (TOP1Ac)

303I

domain III
248P, 249P, 250L, 251A, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261S, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271R, 272T, 273M, 274M, 275L, 276A, 277Q, 278K, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305Q, 306E, 307A, 308K, 309E, 310M, 311A, 312K, 313S, 314Y, 315I, 316T, 317E, 318T, 319F, 340A, 341H, 342E, 343A, 344I, 345R, 346P, 347T, 348D, 360L, 361E, 362K, 363D, 364Q, 365W, 366K, 367L, 368Y, 369K, 370L, 371I, 372W, 373E, 374R, 375F, 376L, 377I, 378S, 379E, 380L
CDD
cd00186 (TOP1Ac)

304S

domain III
248P, 249P, 250L, 251A, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261S, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271R, 272T, 273M, 274M, 275L, 276A, 277Q, 278K, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305Q, 306E, 307A, 308K, 309E, 310M, 311A, 312K, 313S, 314Y, 315I, 316T, 317E, 318T, 319F, 340A, 341H, 342E, 343A, 344I, 345R, 346P, 347T, 348D, 360L, 361E, 362K, 363D, 364Q, 365W, 366K, 367L, 368Y, 369K, 370L, 371I, 372W, 373E, 374R, 375F, 376L, 377I, 378S, 379E, 380L
CDD
cd00186 (TOP1Ac)

305Q

domain III
248P, 249P, 250L, 251A, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261S, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271R, 272T, 273M, 274M, 275L, 276A, 277Q, 278K, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305Q, 306E, 307A, 308K, 309E, 310M, 311A, 312K, 313S, 314Y, 315I, 316T, 317E, 318T, 319F, 340A, 341H, 342E, 343A, 344I, 345R, 346P, 347T, 348D, 360L, 361E, 362K, 363D, 364Q, 365W, 366K, 367L, 368Y, 369K, 370L, 371I, 372W, 373E, 374R, 375F, 376L, 377I, 378S, 379E, 380L
CDD
cd00186 (TOP1Ac)

306E

domain III
248P, 249P, 250L, 251A, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261S, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271R, 272T, 273M, 274M, 275L, 276A, 277Q, 278K, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305Q, 306E, 307A, 308K, 309E, 310M, 311A, 312K, 313S, 314Y, 315I, 316T, 317E, 318T, 319F, 340A, 341H, 342E, 343A, 344I, 345R, 346P, 347T, 348D, 360L, 361E, 362K, 363D, 364Q, 365W, 366K, 367L, 368Y, 369K, 370L, 371I, 372W, 373E, 374R, 375F, 376L, 377I, 378S, 379E, 380L
CDD
cd00186 (TOP1Ac)

307A

domain III
248P, 249P, 250L, 251A, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261S, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271R, 272T, 273M, 274M, 275L, 276A, 277Q, 278K, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305Q, 306E, 307A, 308K, 309E, 310M, 311A, 312K, 313S, 314Y, 315I, 316T, 317E, 318T, 319F, 340A, 341H, 342E, 343A, 344I, 345R, 346P, 347T, 348D, 360L, 361E, 362K, 363D, 364Q, 365W, 366K, 367L, 368Y, 369K, 370L, 371I, 372W, 373E, 374R, 375F, 376L, 377I, 378S, 379E, 380L
CDD
cd00186 (TOP1Ac)

308K

domain III
248P, 249P, 250L, 251A, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261S, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271R, 272T, 273M, 274M, 275L, 276A, 277Q, 278K, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305Q, 306E, 307A, 308K, 309E, 310M, 311A, 312K, 313S, 314Y, 315I, 316T, 317E, 318T, 319F, 340A, 341H, 342E, 343A, 344I, 345R, 346P, 347T, 348D, 360L, 361E, 362K, 363D, 364Q, 365W, 366K, 367L, 368Y, 369K, 370L, 371I, 372W, 373E, 374R, 375F, 376L, 377I, 378S, 379E, 380L
CDD
cd00186 (TOP1Ac)

309E

domain III
248P, 249P, 250L, 251A, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261S, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271R, 272T, 273M, 274M, 275L, 276A, 277Q, 278K, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305Q, 306E, 307A, 308K, 309E, 310M, 311A, 312K, 313S, 314Y, 315I, 316T, 317E, 318T, 319F, 340A, 341H, 342E, 343A, 344I, 345R, 346P, 347T, 348D, 360L, 361E, 362K, 363D, 364Q, 365W, 366K, 367L, 368Y, 369K, 370L, 371I, 372W, 373E, 374R, 375F, 376L, 377I, 378S, 379E, 380L
CDD
cd00186 (TOP1Ac)

310M

domain III
248P, 249P, 250L, 251A, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261S, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271R, 272T, 273M, 274M, 275L, 276A, 277Q, 278K, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305Q, 306E, 307A, 308K, 309E, 310M, 311A, 312K, 313S, 314Y, 315I, 316T, 317E, 318T, 319F, 340A, 341H, 342E, 343A, 344I, 345R, 346P, 347T, 348D, 360L, 361E, 362K, 363D, 364Q, 365W, 366K, 367L, 368Y, 369K, 370L, 371I, 372W, 373E, 374R, 375F, 376L, 377I, 378S, 379E, 380L
CDD
cd00186 (TOP1Ac)

311A

domain III
248P, 249P, 250L, 251A, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261S, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271R, 272T, 273M, 274M, 275L, 276A, 277Q, 278K, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305Q, 306E, 307A, 308K, 309E, 310M, 311A, 312K, 313S, 314Y, 315I, 316T, 317E, 318T, 319F, 340A, 341H, 342E, 343A, 344I, 345R, 346P, 347T, 348D, 360L, 361E, 362K, 363D, 364Q, 365W, 366K, 367L, 368Y, 369K, 370L, 371I, 372W, 373E, 374R, 375F, 376L, 377I, 378S, 379E, 380L
CDD
cd00186 (TOP1Ac)

312K

domain III
248P, 249P, 250L, 251A, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261S, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271R, 272T, 273M, 274M, 275L, 276A, 277Q, 278K, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305Q, 306E, 307A, 308K, 309E, 310M, 311A, 312K, 313S, 314Y, 315I, 316T, 317E, 318T, 319F, 340A, 341H, 342E, 343A, 344I, 345R, 346P, 347T, 348D, 360L, 361E, 362K, 363D, 364Q, 365W, 366K, 367L, 368Y, 369K, 370L, 371I, 372W, 373E, 374R, 375F, 376L, 377I, 378S, 379E, 380L
CDD
cd00186 (TOP1Ac)

313S

domain III
248P, 249P, 250L, 251A, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261S, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271R, 272T, 273M, 274M, 275L, 276A, 277Q, 278K, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305Q, 306E, 307A, 308K, 309E, 310M, 311A, 312K, 313S, 314Y, 315I, 316T, 317E, 318T, 319F, 340A, 341H, 342E, 343A, 344I, 345R, 346P, 347T, 348D, 360L, 361E, 362K, 363D, 364Q, 365W, 366K, 367L, 368Y, 369K, 370L, 371I, 372W, 373E, 374R, 375F, 376L, 377I, 378S, 379E, 380L
CDD
cd00186 (TOP1Ac)

314Y

domain III
248P, 249P, 250L, 251A, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261S, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271R, 272T, 273M, 274M, 275L, 276A, 277Q, 278K, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305Q, 306E, 307A, 308K, 309E, 310M, 311A, 312K, 313S, 314Y, 315I, 316T, 317E, 318T, 319F, 340A, 341H, 342E, 343A, 344I, 345R, 346P, 347T, 348D, 360L, 361E, 362K, 363D, 364Q, 365W, 366K, 367L, 368Y, 369K, 370L, 371I, 372W, 373E, 374R, 375F, 376L, 377I, 378S, 379E, 380L
CDD
cd00186 (TOP1Ac)

315I

domain III
248P, 249P, 250L, 251A, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261S, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271R, 272T, 273M, 274M, 275L, 276A, 277Q, 278K, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305Q, 306E, 307A, 308K, 309E, 310M, 311A, 312K, 313S, 314Y, 315I, 316T, 317E, 318T, 319F, 340A, 341H, 342E, 343A, 344I, 345R, 346P, 347T, 348D, 360L, 361E, 362K, 363D, 364Q, 365W, 366K, 367L, 368Y, 369K, 370L, 371I, 372W, 373E, 374R, 375F, 376L, 377I, 378S, 379E, 380L
CDD
cd00186 (TOP1Ac)

316T

domain III
248P, 249P, 250L, 251A, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261S, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271R, 272T, 273M, 274M, 275L, 276A, 277Q, 278K, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305Q, 306E, 307A, 308K, 309E, 310M, 311A, 312K, 313S, 314Y, 315I, 316T, 317E, 318T, 319F, 340A, 341H, 342E, 343A, 344I, 345R, 346P, 347T, 348D, 360L, 361E, 362K, 363D, 364Q, 365W, 366K, 367L, 368Y, 369K, 370L, 371I, 372W, 373E, 374R, 375F, 376L, 377I, 378S, 379E, 380L
CDD
cd00186 (TOP1Ac)

317E

domain III
248P, 249P, 250L, 251A, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261S, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271R, 272T, 273M, 274M, 275L, 276A, 277Q, 278K, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305Q, 306E, 307A, 308K, 309E, 310M, 311A, 312K, 313S, 314Y, 315I, 316T, 317E, 318T, 319F, 340A, 341H, 342E, 343A, 344I, 345R, 346P, 347T, 348D, 360L, 361E, 362K, 363D, 364Q, 365W, 366K, 367L, 368Y, 369K, 370L, 371I, 372W, 373E, 374R, 375F, 376L, 377I, 378S, 379E, 380L
CDD
cd00186 (TOP1Ac)

318T

domain III
248P, 249P, 250L, 251A, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261S, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271R, 272T, 273M, 274M, 275L, 276A, 277Q, 278K, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305Q, 306E, 307A, 308K, 309E, 310M, 311A, 312K, 313S, 314Y, 315I, 316T, 317E, 318T, 319F, 340A, 341H, 342E, 343A, 344I, 345R, 346P, 347T, 348D, 360L, 361E, 362K, 363D, 364Q, 365W, 366K, 367L, 368Y, 369K, 370L, 371I, 372W, 373E, 374R, 375F, 376L, 377I, 378S, 379E, 380L
CDD
cd00186 (TOP1Ac)

319F

domain III
248P, 249P, 250L, 251A, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261S, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271R, 272T, 273M, 274M, 275L, 276A, 277Q, 278K, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305Q, 306E, 307A, 308K, 309E, 310M, 311A, 312K, 313S, 314Y, 315I, 316T, 317E, 318T, 319F, 340A, 341H, 342E, 343A, 344I, 345R, 346P, 347T, 348D, 360L, 361E, 362K, 363D, 364Q, 365W, 366K, 367L, 368Y, 369K, 370L, 371I, 372W, 373E, 374R, 375F, 376L, 377I, 378S, 379E, 380L
CDD
cd00186 (TOP1Ac)

340A

domain III
248P, 249P, 250L, 251A, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261S, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271R, 272T, 273M, 274M, 275L, 276A, 277Q, 278K, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305Q, 306E, 307A, 308K, 309E, 310M, 311A, 312K, 313S, 314Y, 315I, 316T, 317E, 318T, 319F, 340A, 341H, 342E, 343A, 344I, 345R, 346P, 347T, 348D, 360L, 361E, 362K, 363D, 364Q, 365W, 366K, 367L, 368Y, 369K, 370L, 371I, 372W, 373E, 374R, 375F, 376L, 377I, 378S, 379E, 380L
CDD
cd00186 (TOP1Ac)

341H

domain III
248P, 249P, 250L, 251A, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261S, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271R, 272T, 273M, 274M, 275L, 276A, 277Q, 278K, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305Q, 306E, 307A, 308K, 309E, 310M, 311A, 312K, 313S, 314Y, 315I, 316T, 317E, 318T, 319F, 340A, 341H, 342E, 343A, 344I, 345R, 346P, 347T, 348D, 360L, 361E, 362K, 363D, 364Q, 365W, 366K, 367L, 368Y, 369K, 370L, 371I, 372W, 373E, 374R, 375F, 376L, 377I, 378S, 379E, 380L
CDD
cd00186 (TOP1Ac)

342E

domain III
248P, 249P, 250L, 251A, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261S, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271R, 272T, 273M, 274M, 275L, 276A, 277Q, 278K, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305Q, 306E, 307A, 308K, 309E, 310M, 311A, 312K, 313S, 314Y, 315I, 316T, 317E, 318T, 319F, 340A, 341H, 342E, 343A, 344I, 345R, 346P, 347T, 348D, 360L, 361E, 362K, 363D, 364Q, 365W, 366K, 367L, 368Y, 369K, 370L, 371I, 372W, 373E, 374R, 375F, 376L, 377I, 378S, 379E, 380L
CDD
cd00186 (TOP1Ac)

343A

domain III
248P, 249P, 250L, 251A, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261S, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271R, 272T, 273M, 274M, 275L, 276A, 277Q, 278K, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305Q, 306E, 307A, 308K, 309E, 310M, 311A, 312K, 313S, 314Y, 315I, 316T, 317E, 318T, 319F, 340A, 341H, 342E, 343A, 344I, 345R, 346P, 347T, 348D, 360L, 361E, 362K, 363D, 364Q, 365W, 366K, 367L, 368Y, 369K, 370L, 371I, 372W, 373E, 374R, 375F, 376L, 377I, 378S, 379E, 380L
CDD
cd00186 (TOP1Ac)

344I

domain III
248P, 249P, 250L, 251A, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261S, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271R, 272T, 273M, 274M, 275L, 276A, 277Q, 278K, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305Q, 306E, 307A, 308K, 309E, 310M, 311A, 312K, 313S, 314Y, 315I, 316T, 317E, 318T, 319F, 340A, 341H, 342E, 343A, 344I, 345R, 346P, 347T, 348D, 360L, 361E, 362K, 363D, 364Q, 365W, 366K, 367L, 368Y, 369K, 370L, 371I, 372W, 373E, 374R, 375F, 376L, 377I, 378S, 379E, 380L
CDD
cd00186 (TOP1Ac)

345R

domain III
248P, 249P, 250L, 251A, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261S, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271R, 272T, 273M, 274M, 275L, 276A, 277Q, 278K, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305Q, 306E, 307A, 308K, 309E, 310M, 311A, 312K, 313S, 314Y, 315I, 316T, 317E, 318T, 319F, 340A, 341H, 342E, 343A, 344I, 345R, 346P, 347T, 348D, 360L, 361E, 362K, 363D, 364Q, 365W, 366K, 367L, 368Y, 369K, 370L, 371I, 372W, 373E, 374R, 375F, 376L, 377I, 378S, 379E, 380L
CDD
cd00186 (TOP1Ac)

346P

domain III
248P, 249P, 250L, 251A, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261S, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271R, 272T, 273M, 274M, 275L, 276A, 277Q, 278K, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305Q, 306E, 307A, 308K, 309E, 310M, 311A, 312K, 313S, 314Y, 315I, 316T, 317E, 318T, 319F, 340A, 341H, 342E, 343A, 344I, 345R, 346P, 347T, 348D, 360L, 361E, 362K, 363D, 364Q, 365W, 366K, 367L, 368Y, 369K, 370L, 371I, 372W, 373E, 374R, 375F, 376L, 377I, 378S, 379E, 380L
CDD
cd00186 (TOP1Ac)

347T

domain III
248P, 249P, 250L, 251A, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261S, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271R, 272T, 273M, 274M, 275L, 276A, 277Q, 278K, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305Q, 306E, 307A, 308K, 309E, 310M, 311A, 312K, 313S, 314Y, 315I, 316T, 317E, 318T, 319F, 340A, 341H, 342E, 343A, 344I, 345R, 346P, 347T, 348D, 360L, 361E, 362K, 363D, 364Q, 365W, 366K, 367L, 368Y, 369K, 370L, 371I, 372W, 373E, 374R, 375F, 376L, 377I, 378S, 379E, 380L
CDD
cd00186 (TOP1Ac)

348D

domain III
248P, 249P, 250L, 251A, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261S, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271R, 272T, 273M, 274M, 275L, 276A, 277Q, 278K, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305Q, 306E, 307A, 308K, 309E, 310M, 311A, 312K, 313S, 314Y, 315I, 316T, 317E, 318T, 319F, 340A, 341H, 342E, 343A, 344I, 345R, 346P, 347T, 348D, 360L, 361E, 362K, 363D, 364Q, 365W, 366K, 367L, 368Y, 369K, 370L, 371I, 372W, 373E, 374R, 375F, 376L, 377I, 378S, 379E, 380L
CDD
cd00186 (TOP1Ac)

360L

domain III
248P, 249P, 250L, 251A, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261S, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271R, 272T, 273M, 274M, 275L, 276A, 277Q, 278K, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305Q, 306E, 307A, 308K, 309E, 310M, 311A, 312K, 313S, 314Y, 315I, 316T, 317E, 318T, 319F, 340A, 341H, 342E, 343A, 344I, 345R, 346P, 347T, 348D, 360L, 361E, 362K, 363D, 364Q, 365W, 366K, 367L, 368Y, 369K, 370L, 371I, 372W, 373E, 374R, 375F, 376L, 377I, 378S, 379E, 380L
CDD
cd00186 (TOP1Ac)

361E

domain III
248P, 249P, 250L, 251A, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261S, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271R, 272T, 273M, 274M, 275L, 276A, 277Q, 278K, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305Q, 306E, 307A, 308K, 309E, 310M, 311A, 312K, 313S, 314Y, 315I, 316T, 317E, 318T, 319F, 340A, 341H, 342E, 343A, 344I, 345R, 346P, 347T, 348D, 360L, 361E, 362K, 363D, 364Q, 365W, 366K, 367L, 368Y, 369K, 370L, 371I, 372W, 373E, 374R, 375F, 376L, 377I, 378S, 379E, 380L
CDD
cd00186 (TOP1Ac)

362K

domain III
248P, 249P, 250L, 251A, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261S, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271R, 272T, 273M, 274M, 275L, 276A, 277Q, 278K, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305Q, 306E, 307A, 308K, 309E, 310M, 311A, 312K, 313S, 314Y, 315I, 316T, 317E, 318T, 319F, 340A, 341H, 342E, 343A, 344I, 345R, 346P, 347T, 348D, 360L, 361E, 362K, 363D, 364Q, 365W, 366K, 367L, 368Y, 369K, 370L, 371I, 372W, 373E, 374R, 375F, 376L, 377I, 378S, 379E, 380L
CDD
cd00186 (TOP1Ac)

363D

domain III
248P, 249P, 250L, 251A, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261S, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271R, 272T, 273M, 274M, 275L, 276A, 277Q, 278K, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305Q, 306E, 307A, 308K, 309E, 310M, 311A, 312K, 313S, 314Y, 315I, 316T, 317E, 318T, 319F, 340A, 341H, 342E, 343A, 344I, 345R, 346P, 347T, 348D, 360L, 361E, 362K, 363D, 364Q, 365W, 366K, 367L, 368Y, 369K, 370L, 371I, 372W, 373E, 374R, 375F, 376L, 377I, 378S, 379E, 380L
CDD
cd00186 (TOP1Ac)

364Q

domain III
248P, 249P, 250L, 251A, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261S, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271R, 272T, 273M, 274M, 275L, 276A, 277Q, 278K, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305Q, 306E, 307A, 308K, 309E, 310M, 311A, 312K, 313S, 314Y, 315I, 316T, 317E, 318T, 319F, 340A, 341H, 342E, 343A, 344I, 345R, 346P, 347T, 348D, 360L, 361E, 362K, 363D, 364Q, 365W, 366K, 367L, 368Y, 369K, 370L, 371I, 372W, 373E, 374R, 375F, 376L, 377I, 378S, 379E, 380L
CDD
cd00186 (TOP1Ac)

365W

domain III
248P, 249P, 250L, 251A, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261S, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271R, 272T, 273M, 274M, 275L, 276A, 277Q, 278K, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305Q, 306E, 307A, 308K, 309E, 310M, 311A, 312K, 313S, 314Y, 315I, 316T, 317E, 318T, 319F, 340A, 341H, 342E, 343A, 344I, 345R, 346P, 347T, 348D, 360L, 361E, 362K, 363D, 364Q, 365W, 366K, 367L, 368Y, 369K, 370L, 371I, 372W, 373E, 374R, 375F, 376L, 377I, 378S, 379E, 380L
CDD
cd00186 (TOP1Ac)

366K

domain III
248P, 249P, 250L, 251A, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261S, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271R, 272T, 273M, 274M, 275L, 276A, 277Q, 278K, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305Q, 306E, 307A, 308K, 309E, 310M, 311A, 312K, 313S, 314Y, 315I, 316T, 317E, 318T, 319F, 340A, 341H, 342E, 343A, 344I, 345R, 346P, 347T, 348D, 360L, 361E, 362K, 363D, 364Q, 365W, 366K, 367L, 368Y, 369K, 370L, 371I, 372W, 373E, 374R, 375F, 376L, 377I, 378S, 379E, 380L
CDD
cd00186 (TOP1Ac)

367L

domain III
248P, 249P, 250L, 251A, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261S, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271R, 272T, 273M, 274M, 275L, 276A, 277Q, 278K, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305Q, 306E, 307A, 308K, 309E, 310M, 311A, 312K, 313S, 314Y, 315I, 316T, 317E, 318T, 319F, 340A, 341H, 342E, 343A, 344I, 345R, 346P, 347T, 348D, 360L, 361E, 362K, 363D, 364Q, 365W, 366K, 367L, 368Y, 369K, 370L, 371I, 372W, 373E, 374R, 375F, 376L, 377I, 378S, 379E, 380L
CDD
cd00186 (TOP1Ac)

368Y

domain III
248P, 249P, 250L, 251A, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261S, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271R, 272T, 273M, 274M, 275L, 276A, 277Q, 278K, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305Q, 306E, 307A, 308K, 309E, 310M, 311A, 312K, 313S, 314Y, 315I, 316T, 317E, 318T, 319F, 340A, 341H, 342E, 343A, 344I, 345R, 346P, 347T, 348D, 360L, 361E, 362K, 363D, 364Q, 365W, 366K, 367L, 368Y, 369K, 370L, 371I, 372W, 373E, 374R, 375F, 376L, 377I, 378S, 379E, 380L
CDD
cd00186 (TOP1Ac)

369K

domain III
248P, 249P, 250L, 251A, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261S, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271R, 272T, 273M, 274M, 275L, 276A, 277Q, 278K, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305Q, 306E, 307A, 308K, 309E, 310M, 311A, 312K, 313S, 314Y, 315I, 316T, 317E, 318T, 319F, 340A, 341H, 342E, 343A, 344I, 345R, 346P, 347T, 348D, 360L, 361E, 362K, 363D, 364Q, 365W, 366K, 367L, 368Y, 369K, 370L, 371I, 372W, 373E, 374R, 375F, 376L, 377I, 378S, 379E, 380L
CDD
cd00186 (TOP1Ac)

370L

domain III
248P, 249P, 250L, 251A, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261S, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271R, 272T, 273M, 274M, 275L, 276A, 277Q, 278K, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305Q, 306E, 307A, 308K, 309E, 310M, 311A, 312K, 313S, 314Y, 315I, 316T, 317E, 318T, 319F, 340A, 341H, 342E, 343A, 344I, 345R, 346P, 347T, 348D, 360L, 361E, 362K, 363D, 364Q, 365W, 366K, 367L, 368Y, 369K, 370L, 371I, 372W, 373E, 374R, 375F, 376L, 377I, 378S, 379E, 380L
CDD
cd00186 (TOP1Ac)

371I

domain III
248P, 249P, 250L, 251A, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261S, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271R, 272T, 273M, 274M, 275L, 276A, 277Q, 278K, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305Q, 306E, 307A, 308K, 309E, 310M, 311A, 312K, 313S, 314Y, 315I, 316T, 317E, 318T, 319F, 340A, 341H, 342E, 343A, 344I, 345R, 346P, 347T, 348D, 360L, 361E, 362K, 363D, 364Q, 365W, 366K, 367L, 368Y, 369K, 370L, 371I, 372W, 373E, 374R, 375F, 376L, 377I, 378S, 379E, 380L
CDD
cd00186 (TOP1Ac)

372W

domain III
248P, 249P, 250L, 251A, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261S, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271R, 272T, 273M, 274M, 275L, 276A, 277Q, 278K, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305Q, 306E, 307A, 308K, 309E, 310M, 311A, 312K, 313S, 314Y, 315I, 316T, 317E, 318T, 319F, 340A, 341H, 342E, 343A, 344I, 345R, 346P, 347T, 348D, 360L, 361E, 362K, 363D, 364Q, 365W, 366K, 367L, 368Y, 369K, 370L, 371I, 372W, 373E, 374R, 375F, 376L, 377I, 378S, 379E, 380L
CDD
cd00186 (TOP1Ac)

373E

domain III
248P, 249P, 250L, 251A, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261S, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271R, 272T, 273M, 274M, 275L, 276A, 277Q, 278K, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305Q, 306E, 307A, 308K, 309E, 310M, 311A, 312K, 313S, 314Y, 315I, 316T, 317E, 318T, 319F, 340A, 341H, 342E, 343A, 344I, 345R, 346P, 347T, 348D, 360L, 361E, 362K, 363D, 364Q, 365W, 366K, 367L, 368Y, 369K, 370L, 371I, 372W, 373E, 374R, 375F, 376L, 377I, 378S, 379E, 380L
CDD
cd00186 (TOP1Ac)

374R

domain III
248P, 249P, 250L, 251A, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261S, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271R, 272T, 273M, 274M, 275L, 276A, 277Q, 278K, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305Q, 306E, 307A, 308K, 309E, 310M, 311A, 312K, 313S, 314Y, 315I, 316T, 317E, 318T, 319F, 340A, 341H, 342E, 343A, 344I, 345R, 346P, 347T, 348D, 360L, 361E, 362K, 363D, 364Q, 365W, 366K, 367L, 368Y, 369K, 370L, 371I, 372W, 373E, 374R, 375F, 376L, 377I, 378S, 379E, 380L
CDD
cd00186 (TOP1Ac)

375F

domain III
248P, 249P, 250L, 251A, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261S, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271R, 272T, 273M, 274M, 275L, 276A, 277Q, 278K, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305Q, 306E, 307A, 308K, 309E, 310M, 311A, 312K, 313S, 314Y, 315I, 316T, 317E, 318T, 319F, 340A, 341H, 342E, 343A, 344I, 345R, 346P, 347T, 348D, 360L, 361E, 362K, 363D, 364Q, 365W, 366K, 367L, 368Y, 369K, 370L, 371I, 372W, 373E, 374R, 375F, 376L, 377I, 378S, 379E, 380L
CDD
cd00186 (TOP1Ac)

376L

domain III
248P, 249P, 250L, 251A, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261S, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271R, 272T, 273M, 274M, 275L, 276A, 277Q, 278K, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305Q, 306E, 307A, 308K, 309E, 310M, 311A, 312K, 313S, 314Y, 315I, 316T, 317E, 318T, 319F, 340A, 341H, 342E, 343A, 344I, 345R, 346P, 347T, 348D, 360L, 361E, 362K, 363D, 364Q, 365W, 366K, 367L, 368Y, 369K, 370L, 371I, 372W, 373E, 374R, 375F, 376L, 377I, 378S, 379E, 380L
CDD
cd00186 (TOP1Ac)

377I

domain III
248P, 249P, 250L, 251A, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261S, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271R, 272T, 273M, 274M, 275L, 276A, 277Q, 278K, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305Q, 306E, 307A, 308K, 309E, 310M, 311A, 312K, 313S, 314Y, 315I, 316T, 317E, 318T, 319F, 340A, 341H, 342E, 343A, 344I, 345R, 346P, 347T, 348D, 360L, 361E, 362K, 363D, 364Q, 365W, 366K, 367L, 368Y, 369K, 370L, 371I, 372W, 373E, 374R, 375F, 376L, 377I, 378S, 379E, 380L
CDD
cd00186 (TOP1Ac)

378S

domain III
248P, 249P, 250L, 251A, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261S, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271R, 272T, 273M, 274M, 275L, 276A, 277Q, 278K, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305Q, 306E, 307A, 308K, 309E, 310M, 311A, 312K, 313S, 314Y, 315I, 316T, 317E, 318T, 319F, 340A, 341H, 342E, 343A, 344I, 345R, 346P, 347T, 348D, 360L, 361E, 362K, 363D, 364Q, 365W, 366K, 367L, 368Y, 369K, 370L, 371I, 372W, 373E, 374R, 375F, 376L, 377I, 378S, 379E, 380L
CDD
cd00186 (TOP1Ac)

379E

domain III
248P, 249P, 250L, 251A, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261S, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271R, 272T, 273M, 274M, 275L, 276A, 277Q, 278K, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305Q, 306E, 307A, 308K, 309E, 310M, 311A, 312K, 313S, 314Y, 315I, 316T, 317E, 318T, 319F, 340A, 341H, 342E, 343A, 344I, 345R, 346P, 347T, 348D, 360L, 361E, 362K, 363D, 364Q, 365W, 366K, 367L, 368Y, 369K, 370L, 371I, 372W, 373E, 374R, 375F, 376L, 377I, 378S, 379E, 380L
CDD
cd00186 (TOP1Ac)

380L

domain III
248P, 249P, 250L, 251A, 252L, 253K, 254T, 256T, 257L, 258Q, 259Q, 260L, 261S, 262S, 263S, 264Y, 265L, 266G, 267F, 268S, 269A, 270S, 271R, 272T, 273M, 274M, 275L, 276A, 277Q, 278K, 279L, 280Y, 281E, 290K, 291G, 292L, 293I, 294T, 295Y, 296M, 297R, 298T, 299D, 300S, 301T, 302R, 303I, 304S, 305Q, 306E, 307A, 308K, 309E, 310M, 311A, 312K, 313S, 314Y, 315I, 316T, 317E, 318T, 319F, 340A, 341H, 342E, 343A, 344I, 345R, 346P, 347T, 348D, 360L, 361E, 362K, 363D, 364Q, 365W, 366K, 367L, 368Y, 369K, 370L, 371I, 372W, 373E, 374R, 375F, 376L, 377I, 378S, 379E, 380L
CDD
cd00186 (TOP1Ac)
nucleotide binding...

259Q

nucleotide binding site
259Q, 263S, 264Y, 265L, 341H, 366K, 369K, 373E, 469R, 471S, 493F
CDD
cd00186 (TOP1Ac)

263S

nucleotide binding site
259Q, 263S, 264Y, 265L, 341H, 366K, 369K, 373E, 469R, 471S, 493F
CDD
cd00186 (TOP1Ac)

264Y

nucleotide binding site
259Q, 263S, 264Y, 265L, 341H, 366K, 369K, 373E, 469R, 471S, 493F
CDD
cd00186 (TOP1Ac)

265L

nucleotide binding site
259Q, 263S, 264Y, 265L, 341H, 366K, 369K, 373E, 469R, 471S, 493F
CDD
cd00186 (TOP1Ac)

341H

nucleotide binding site
259Q, 263S, 264Y, 265L, 341H, 366K, 369K, 373E, 469R, 471S, 493F
CDD
cd00186 (TOP1Ac)

366K

nucleotide binding site
259Q, 263S, 264Y, 265L, 341H, 366K, 369K, 373E, 469R, 471S, 493F
CDD
cd00186 (TOP1Ac)

369K

nucleotide binding site
259Q, 263S, 264Y, 265L, 341H, 366K, 369K, 373E, 469R, 471S, 493F
CDD
cd00186 (TOP1Ac)

373E

nucleotide binding site
259Q, 263S, 264Y, 265L, 341H, 366K, 369K, 373E, 469R, 471S, 493F
CDD
cd00186 (TOP1Ac)

469R

nucleotide binding site
259Q, 263S, 264Y, 265L, 341H, 366K, 369K, 373E, 469R, 471S, 493F
CDD
cd00186 (TOP1Ac)

471S

nucleotide binding site
259Q, 263S, 264Y, 265L, 341H, 366K, 369K, 373E, 469R, 471S, 493F
CDD
cd00186 (TOP1Ac)

493F

nucleotide binding site
259Q, 263S, 264Y, 265L, 341H, 366K, 369K, 373E, 469R, 471S, 493F
CDD
cd00186 (TOP1Ac)
catalytic site cd0...

295Y

catalytic site
295Y, 297R, 341H
CDD
cd00186 (TOP1Ac)

297R

catalytic site
295Y, 297R, 341H
CDD
cd00186 (TOP1Ac)

341H

catalytic site
295Y, 297R, 341H
CDD
cd00186 (TOP1Ac)
domain IV cd00186

449P

domain IV
449P, 450P, 451A, 452R, 453L, 454T, 455E, 456S, 457S, 458L, 459V, 460K, 461M, 462L, 463E, 464T, 465E, 466G, 467I, 468G, 469R, 470P, 471S, 472T, 473Y, 474A, 475T, 476I, 477I, 478E, 479T, 480L, 481K, 482K, 483R, 484E, 485Y, 486I, 487V, 488M, 489E, 493F, 494I, 495P, 496T, 497E, 498I, 499G, 500Y, 501E, 502V, 503K, 504A, 505Q, 506L, 507E, 513I, 514M, 515N, 516V, 517K, 518F, 519T, 520A, 521E, 522L, 523E, 524N, 525E, 526L, 527D, 528G, 529V, 530E, 531L, 532G, 533T, 534E, 535D, 536W, 537I, 538S, 539L, 540L, 541H, 542R, 543F, 544Y, 545D, 546G, 547L, 548K, 549E
CDD
cd00186 (TOP1Ac)

450P

domain IV
449P, 450P, 451A, 452R, 453L, 454T, 455E, 456S, 457S, 458L, 459V, 460K, 461M, 462L, 463E, 464T, 465E, 466G, 467I, 468G, 469R, 470P, 471S, 472T, 473Y, 474A, 475T, 476I, 477I, 478E, 479T, 480L, 481K, 482K, 483R, 484E, 485Y, 486I, 487V, 488M, 489E, 493F, 494I, 495P, 496T, 497E, 498I, 499G, 500Y, 501E, 502V, 503K, 504A, 505Q, 506L, 507E, 513I, 514M, 515N, 516V, 517K, 518F, 519T, 520A, 521E, 522L, 523E, 524N, 525E, 526L, 527D, 528G, 529V, 530E, 531L, 532G, 533T, 534E, 535D, 536W, 537I, 538S, 539L, 540L, 541H, 542R, 543F, 544Y, 545D, 546G, 547L, 548K, 549E
CDD
cd00186 (TOP1Ac)

451A

domain IV
449P, 450P, 451A, 452R, 453L, 454T, 455E, 456S, 457S, 458L, 459V, 460K, 461M, 462L, 463E, 464T, 465E, 466G, 467I, 468G, 469R, 470P, 471S, 472T, 473Y, 474A, 475T, 476I, 477I, 478E, 479T, 480L, 481K, 482K, 483R, 484E, 485Y, 486I, 487V, 488M, 489E, 493F, 494I, 495P, 496T, 497E, 498I, 499G, 500Y, 501E, 502V, 503K, 504A, 505Q, 506L, 507E, 513I, 514M, 515N, 516V, 517K, 518F, 519T, 520A, 521E, 522L, 523E, 524N, 525E, 526L, 527D, 528G, 529V, 530E, 531L, 532G, 533T, 534E, 535D, 536W, 537I, 538S, 539L, 540L, 541H, 542R, 543F, 544Y, 545D, 546G, 547L, 548K, 549E
CDD
cd00186 (TOP1Ac)

452R

domain IV
449P, 450P, 451A, 452R, 453L, 454T, 455E, 456S, 457S, 458L, 459V, 460K, 461M, 462L, 463E, 464T, 465E, 466G, 467I, 468G, 469R, 470P, 471S, 472T, 473Y, 474A, 475T, 476I, 477I, 478E, 479T, 480L, 481K, 482K, 483R, 484E, 485Y, 486I, 487V, 488M, 489E, 493F, 494I, 495P, 496T, 497E, 498I, 499G, 500Y, 501E, 502V, 503K, 504A, 505Q, 506L, 507E, 513I, 514M, 515N, 516V, 517K, 518F, 519T, 520A, 521E, 522L, 523E, 524N, 525E, 526L, 527D, 528G, 529V, 530E, 531L, 532G, 533T, 534E, 535D, 536W, 537I, 538S, 539L, 540L, 541H, 542R, 543F, 544Y, 545D, 546G, 547L, 548K, 549E
CDD
cd00186 (TOP1Ac)

453L

domain IV
449P, 450P, 451A, 452R, 453L, 454T, 455E, 456S, 457S, 458L, 459V, 460K, 461M, 462L, 463E, 464T, 465E, 466G, 467I, 468G, 469R, 470P, 471S, 472T, 473Y, 474A, 475T, 476I, 477I, 478E, 479T, 480L, 481K, 482K, 483R, 484E, 485Y, 486I, 487V, 488M, 489E, 493F, 494I, 495P, 496T, 497E, 498I, 499G, 500Y, 501E, 502V, 503K, 504A, 505Q, 506L, 507E, 513I, 514M, 515N, 516V, 517K, 518F, 519T, 520A, 521E, 522L, 523E, 524N, 525E, 526L, 527D, 528G, 529V, 530E, 531L, 532G, 533T, 534E, 535D, 536W, 537I, 538S, 539L, 540L, 541H, 542R, 543F, 544Y, 545D, 546G, 547L, 548K, 549E
CDD
cd00186 (TOP1Ac)

454T

domain IV
449P, 450P, 451A, 452R, 453L, 454T, 455E, 456S, 457S, 458L, 459V, 460K, 461M, 462L, 463E, 464T, 465E, 466G, 467I, 468G, 469R, 470P, 471S, 472T, 473Y, 474A, 475T, 476I, 477I, 478E, 479T, 480L, 481K, 482K, 483R, 484E, 485Y, 486I, 487V, 488M, 489E, 493F, 494I, 495P, 496T, 497E, 498I, 499G, 500Y, 501E, 502V, 503K, 504A, 505Q, 506L, 507E, 513I, 514M, 515N, 516V, 517K, 518F, 519T, 520A, 521E, 522L, 523E, 524N, 525E, 526L, 527D, 528G, 529V, 530E, 531L, 532G, 533T, 534E, 535D, 536W, 537I, 538S, 539L, 540L, 541H, 542R, 543F, 544Y, 545D, 546G, 547L, 548K, 549E
CDD
cd00186 (TOP1Ac)

455E

domain IV
449P, 450P, 451A, 452R, 453L, 454T, 455E, 456S, 457S, 458L, 459V, 460K, 461M, 462L, 463E, 464T, 465E, 466G, 467I, 468G, 469R, 470P, 471S, 472T, 473Y, 474A, 475T, 476I, 477I, 478E, 479T, 480L, 481K, 482K, 483R, 484E, 485Y, 486I, 487V, 488M, 489E, 493F, 494I, 495P, 496T, 497E, 498I, 499G, 500Y, 501E, 502V, 503K, 504A, 505Q, 506L, 507E, 513I, 514M, 515N, 516V, 517K, 518F, 519T, 520A, 521E, 522L, 523E, 524N, 525E, 526L, 527D, 528G, 529V, 530E, 531L, 532G, 533T, 534E, 535D, 536W, 537I, 538S, 539L, 540L, 541H, 542R, 543F, 544Y, 545D, 546G, 547L, 548K, 549E
CDD
cd00186 (TOP1Ac)

456S

domain IV
449P, 450P, 451A, 452R, 453L, 454T, 455E, 456S, 457S, 458L, 459V, 460K, 461M, 462L, 463E, 464T, 465E, 466G, 467I, 468G, 469R, 470P, 471S, 472T, 473Y, 474A, 475T, 476I, 477I, 478E, 479T, 480L, 481K, 482K, 483R, 484E, 485Y, 486I, 487V, 488M, 489E, 493F, 494I, 495P, 496T, 497E, 498I, 499G, 500Y, 501E, 502V, 503K, 504A, 505Q, 506L, 507E, 513I, 514M, 515N, 516V, 517K, 518F, 519T, 520A, 521E, 522L, 523E, 524N, 525E, 526L, 527D, 528G, 529V, 530E, 531L, 532G, 533T, 534E, 535D, 536W, 537I, 538S, 539L, 540L, 541H, 542R, 543F, 544Y, 545D, 546G, 547L, 548K, 549E
CDD
cd00186 (TOP1Ac)

457S

domain IV
449P, 450P, 451A, 452R, 453L, 454T, 455E, 456S, 457S, 458L, 459V, 460K, 461M, 462L, 463E, 464T, 465E, 466G, 467I, 468G, 469R, 470P, 471S, 472T, 473Y, 474A, 475T, 476I, 477I, 478E, 479T, 480L, 481K, 482K, 483R, 484E, 485Y, 486I, 487V, 488M, 489E, 493F, 494I, 495P, 496T, 497E, 498I, 499G, 500Y, 501E, 502V, 503K, 504A, 505Q, 506L, 507E, 513I, 514M, 515N, 516V, 517K, 518F, 519T, 520A, 521E, 522L, 523E, 524N, 525E, 526L, 527D, 528G, 529V, 530E, 531L, 532G, 533T, 534E, 535D, 536W, 537I, 538S, 539L, 540L, 541H, 542R, 543F, 544Y, 545D, 546G, 547L, 548K, 549E
CDD
cd00186 (TOP1Ac)

458L

domain IV
449P, 450P, 451A, 452R, 453L, 454T, 455E, 456S, 457S, 458L, 459V, 460K, 461M, 462L, 463E, 464T, 465E, 466G, 467I, 468G, 469R, 470P, 471S, 472T, 473Y, 474A, 475T, 476I, 477I, 478E, 479T, 480L, 481K, 482K, 483R, 484E, 485Y, 486I, 487V, 488M, 489E, 493F, 494I, 495P, 496T, 497E, 498I, 499G, 500Y, 501E, 502V, 503K, 504A, 505Q, 506L, 507E, 513I, 514M, 515N, 516V, 517K, 518F, 519T, 520A, 521E, 522L, 523E, 524N, 525E, 526L, 527D, 528G, 529V, 530E, 531L, 532G, 533T, 534E, 535D, 536W, 537I, 538S, 539L, 540L, 541H, 542R, 543F, 544Y, 545D, 546G, 547L, 548K, 549E
CDD
cd00186 (TOP1Ac)

459V

domain IV
449P, 450P, 451A, 452R, 453L, 454T, 455E, 456S, 457S, 458L, 459V, 460K, 461M, 462L, 463E, 464T, 465E, 466G, 467I, 468G, 469R, 470P, 471S, 472T, 473Y, 474A, 475T, 476I, 477I, 478E, 479T, 480L, 481K, 482K, 483R, 484E, 485Y, 486I, 487V, 488M, 489E, 493F, 494I, 495P, 496T, 497E, 498I, 499G, 500Y, 501E, 502V, 503K, 504A, 505Q, 506L, 507E, 513I, 514M, 515N, 516V, 517K, 518F, 519T, 520A, 521E, 522L, 523E, 524N, 525E, 526L, 527D, 528G, 529V, 530E, 531L, 532G, 533T, 534E, 535D, 536W, 537I, 538S, 539L, 540L, 541H, 542R, 543F, 544Y, 545D, 546G, 547L, 548K, 549E
CDD
cd00186 (TOP1Ac)

460K

domain IV
449P, 450P, 451A, 452R, 453L, 454T, 455E, 456S, 457S, 458L, 459V, 460K, 461M, 462L, 463E, 464T, 465E, 466G, 467I, 468G, 469R, 470P, 471S, 472T, 473Y, 474A, 475T, 476I, 477I, 478E, 479T, 480L, 481K, 482K, 483R, 484E, 485Y, 486I, 487V, 488M, 489E, 493F, 494I, 495P, 496T, 497E, 498I, 499G, 500Y, 501E, 502V, 503K, 504A, 505Q, 506L, 507E, 513I, 514M, 515N, 516V, 517K, 518F, 519T, 520A, 521E, 522L, 523E, 524N, 525E, 526L, 527D, 528G, 529V, 530E, 531L, 532G, 533T, 534E, 535D, 536W, 537I, 538S, 539L, 540L, 541H, 542R, 543F, 544Y, 545D, 546G, 547L, 548K, 549E
CDD
cd00186 (TOP1Ac)

461M

domain IV
449P, 450P, 451A, 452R, 453L, 454T, 455E, 456S, 457S, 458L, 459V, 460K, 461M, 462L, 463E, 464T, 465E, 466G, 467I, 468G, 469R, 470P, 471S, 472T, 473Y, 474A, 475T, 476I, 477I, 478E, 479T, 480L, 481K, 482K, 483R, 484E, 485Y, 486I, 487V, 488M, 489E, 493F, 494I, 495P, 496T, 497E, 498I, 499G, 500Y, 501E, 502V, 503K, 504A, 505Q, 506L, 507E, 513I, 514M, 515N, 516V, 517K, 518F, 519T, 520A, 521E, 522L, 523E, 524N, 525E, 526L, 527D, 528G, 529V, 530E, 531L, 532G, 533T, 534E, 535D, 536W, 537I, 538S, 539L, 540L, 541H, 542R, 543F, 544Y, 545D, 546G, 547L, 548K, 549E
CDD
cd00186 (TOP1Ac)

462L

domain IV
449P, 450P, 451A, 452R, 453L, 454T, 455E, 456S, 457S, 458L, 459V, 460K, 461M, 462L, 463E, 464T, 465E, 466G, 467I, 468G, 469R, 470P, 471S, 472T, 473Y, 474A, 475T, 476I, 477I, 478E, 479T, 480L, 481K, 482K, 483R, 484E, 485Y, 486I, 487V, 488M, 489E, 493F, 494I, 495P, 496T, 497E, 498I, 499G, 500Y, 501E, 502V, 503K, 504A, 505Q, 506L, 507E, 513I, 514M, 515N, 516V, 517K, 518F, 519T, 520A, 521E, 522L, 523E, 524N, 525E, 526L, 527D, 528G, 529V, 530E, 531L, 532G, 533T, 534E, 535D, 536W, 537I, 538S, 539L, 540L, 541H, 542R, 543F, 544Y, 545D, 546G, 547L, 548K, 549E
CDD
cd00186 (TOP1Ac)

463E

domain IV
449P, 450P, 451A, 452R, 453L, 454T, 455E, 456S, 457S, 458L, 459V, 460K, 461M, 462L, 463E, 464T, 465E, 466G, 467I, 468G, 469R, 470P, 471S, 472T, 473Y, 474A, 475T, 476I, 477I, 478E, 479T, 480L, 481K, 482K, 483R, 484E, 485Y, 486I, 487V, 488M, 489E, 493F, 494I, 495P, 496T, 497E, 498I, 499G, 500Y, 501E, 502V, 503K, 504A, 505Q, 506L, 507E, 513I, 514M, 515N, 516V, 517K, 518F, 519T, 520A, 521E, 522L, 523E, 524N, 525E, 526L, 527D, 528G, 529V, 530E, 531L, 532G, 533T, 534E, 535D, 536W, 537I, 538S, 539L, 540L, 541H, 542R, 543F, 544Y, 545D, 546G, 547L, 548K, 549E
CDD
cd00186 (TOP1Ac)

464T

domain IV
449P, 450P, 451A, 452R, 453L, 454T, 455E, 456S, 457S, 458L, 459V, 460K, 461M, 462L, 463E, 464T, 465E, 466G, 467I, 468G, 469R, 470P, 471S, 472T, 473Y, 474A, 475T, 476I, 477I, 478E, 479T, 480L, 481K, 482K, 483R, 484E, 485Y, 486I, 487V, 488M, 489E, 493F, 494I, 495P, 496T, 497E, 498I, 499G, 500Y, 501E, 502V, 503K, 504A, 505Q, 506L, 507E, 513I, 514M, 515N, 516V, 517K, 518F, 519T, 520A, 521E, 522L, 523E, 524N, 525E, 526L, 527D, 528G, 529V, 530E, 531L, 532G, 533T, 534E, 535D, 536W, 537I, 538S, 539L, 540L, 541H, 542R, 543F, 544Y, 545D, 546G, 547L, 548K, 549E
CDD
cd00186 (TOP1Ac)

465E

domain IV
449P, 450P, 451A, 452R, 453L, 454T, 455E, 456S, 457S, 458L, 459V, 460K, 461M, 462L, 463E, 464T, 465E, 466G, 467I, 468G, 469R, 470P, 471S, 472T, 473Y, 474A, 475T, 476I, 477I, 478E, 479T, 480L, 481K, 482K, 483R, 484E, 485Y, 486I, 487V, 488M, 489E, 493F, 494I, 495P, 496T, 497E, 498I, 499G, 500Y, 501E, 502V, 503K, 504A, 505Q, 506L, 507E, 513I, 514M, 515N, 516V, 517K, 518F, 519T, 520A, 521E, 522L, 523E, 524N, 525E, 526L, 527D, 528G, 529V, 530E, 531L, 532G, 533T, 534E, 535D, 536W, 537I, 538S, 539L, 540L, 541H, 542R, 543F, 544Y, 545D, 546G, 547L, 548K, 549E
CDD
cd00186 (TOP1Ac)

466G

domain IV
449P, 450P, 451A, 452R, 453L, 454T, 455E, 456S, 457S, 458L, 459V, 460K, 461M, 462L, 463E, 464T, 465E, 466G, 467I, 468G, 469R, 470P, 471S, 472T, 473Y, 474A, 475T, 476I, 477I, 478E, 479T, 480L, 481K, 482K, 483R, 484E, 485Y, 486I, 487V, 488M, 489E, 493F, 494I, 495P, 496T, 497E, 498I, 499G, 500Y, 501E, 502V, 503K, 504A, 505Q, 506L, 507E, 513I, 514M, 515N, 516V, 517K, 518F, 519T, 520A, 521E, 522L, 523E, 524N, 525E, 526L, 527D, 528G, 529V, 530E, 531L, 532G, 533T, 534E, 535D, 536W, 537I, 538S, 539L, 540L, 541H, 542R, 543F, 544Y, 545D, 546G, 547L, 548K, 549E
CDD
cd00186 (TOP1Ac)

467I

domain IV
449P, 450P, 451A, 452R, 453L, 454T, 455E, 456S, 457S, 458L, 459V, 460K, 461M, 462L, 463E, 464T, 465E, 466G, 467I, 468G, 469R, 470P, 471S, 472T, 473Y, 474A, 475T, 476I, 477I, 478E, 479T, 480L, 481K, 482K, 483R, 484E, 485Y, 486I, 487V, 488M, 489E, 493F, 494I, 495P, 496T, 497E, 498I, 499G, 500Y, 501E, 502V, 503K, 504A, 505Q, 506L, 507E, 513I, 514M, 515N, 516V, 517K, 518F, 519T, 520A, 521E, 522L, 523E, 524N, 525E, 526L, 527D, 528G, 529V, 530E, 531L, 532G, 533T, 534E, 535D, 536W, 537I, 538S, 539L, 540L, 541H, 542R, 543F, 544Y, 545D, 546G, 547L, 548K, 549E
CDD
cd00186 (TOP1Ac)

468G

domain IV
449P, 450P, 451A, 452R, 453L, 454T, 455E, 456S, 457S, 458L, 459V, 460K, 461M, 462L, 463E, 464T, 465E, 466G, 467I, 468G, 469R, 470P, 471S, 472T, 473Y, 474A, 475T, 476I, 477I, 478E, 479T, 480L, 481K, 482K, 483R, 484E, 485Y, 486I, 487V, 488M, 489E, 493F, 494I, 495P, 496T, 497E, 498I, 499G, 500Y, 501E, 502V, 503K, 504A, 505Q, 506L, 507E, 513I, 514M, 515N, 516V, 517K, 518F, 519T, 520A, 521E, 522L, 523E, 524N, 525E, 526L, 527D, 528G, 529V, 530E, 531L, 532G, 533T, 534E, 535D, 536W, 537I, 538S, 539L, 540L, 541H, 542R, 543F, 544Y, 545D, 546G, 547L, 548K, 549E
CDD
cd00186 (TOP1Ac)

469R

domain IV
449P, 450P, 451A, 452R, 453L, 454T, 455E, 456S, 457S, 458L, 459V, 460K, 461M, 462L, 463E, 464T, 465E, 466G, 467I, 468G, 469R, 470P, 471S, 472T, 473Y, 474A, 475T, 476I, 477I, 478E, 479T, 480L, 481K, 482K, 483R, 484E, 485Y, 486I, 487V, 488M, 489E, 493F, 494I, 495P, 496T, 497E, 498I, 499G, 500Y, 501E, 502V, 503K, 504A, 505Q, 506L, 507E, 513I, 514M, 515N, 516V, 517K, 518F, 519T, 520A, 521E, 522L, 523E, 524N, 525E, 526L, 527D, 528G, 529V, 530E, 531L, 532G, 533T, 534E, 535D, 536W, 537I, 538S, 539L, 540L, 541H, 542R, 543F, 544Y, 545D, 546G, 547L, 548K, 549E
CDD
cd00186 (TOP1Ac)

470P

domain IV
449P, 450P, 451A, 452R, 453L, 454T, 455E, 456S, 457S, 458L, 459V, 460K, 461M, 462L, 463E, 464T, 465E, 466G, 467I, 468G, 469R, 470P, 471S, 472T, 473Y, 474A, 475T, 476I, 477I, 478E, 479T, 480L, 481K, 482K, 483R, 484E, 485Y, 486I, 487V, 488M, 489E, 493F, 494I, 495P, 496T, 497E, 498I, 499G, 500Y, 501E, 502V, 503K, 504A, 505Q, 506L, 507E, 513I, 514M, 515N, 516V, 517K, 518F, 519T, 520A, 521E, 522L, 523E, 524N, 525E, 526L, 527D, 528G, 529V, 530E, 531L, 532G, 533T, 534E, 535D, 536W, 537I, 538S, 539L, 540L, 541H, 542R, 543F, 544Y, 545D, 546G, 547L, 548K, 549E
CDD
cd00186 (TOP1Ac)

471S

domain IV
449P, 450P, 451A, 452R, 453L, 454T, 455E, 456S, 457S, 458L, 459V, 460K, 461M, 462L, 463E, 464T, 465E, 466G, 467I, 468G, 469R, 470P, 471S, 472T, 473Y, 474A, 475T, 476I, 477I, 478E, 479T, 480L, 481K, 482K, 483R, 484E, 485Y, 486I, 487V, 488M, 489E, 493F, 494I, 495P, 496T, 497E, 498I, 499G, 500Y, 501E, 502V, 503K, 504A, 505Q, 506L, 507E, 513I, 514M, 515N, 516V, 517K, 518F, 519T, 520A, 521E, 522L, 523E, 524N, 525E, 526L, 527D, 528G, 529V, 530E, 531L, 532G, 533T, 534E, 535D, 536W, 537I, 538S, 539L, 540L, 541H, 542R, 543F, 544Y, 545D, 546G, 547L, 548K, 549E
CDD
cd00186 (TOP1Ac)

472T

domain IV
449P, 450P, 451A, 452R, 453L, 454T, 455E, 456S, 457S, 458L, 459V, 460K, 461M, 462L, 463E, 464T, 465E, 466G, 467I, 468G, 469R, 470P, 471S, 472T, 473Y, 474A, 475T, 476I, 477I, 478E, 479T, 480L, 481K, 482K, 483R, 484E, 485Y, 486I, 487V, 488M, 489E, 493F, 494I, 495P, 496T, 497E, 498I, 499G, 500Y, 501E, 502V, 503K, 504A, 505Q, 506L, 507E, 513I, 514M, 515N, 516V, 517K, 518F, 519T, 520A, 521E, 522L, 523E, 524N, 525E, 526L, 527D, 528G, 529V, 530E, 531L, 532G, 533T, 534E, 535D, 536W, 537I, 538S, 539L, 540L, 541H, 542R, 543F, 544Y, 545D, 546G, 547L, 548K, 549E
CDD
cd00186 (TOP1Ac)

473Y

domain IV
449P, 450P, 451A, 452R, 453L, 454T, 455E, 456S, 457S, 458L, 459V, 460K, 461M, 462L, 463E, 464T, 465E, 466G, 467I, 468G, 469R, 470P, 471S, 472T, 473Y, 474A, 475T, 476I, 477I, 478E, 479T, 480L, 481K, 482K, 483R, 484E, 485Y, 486I, 487V, 488M, 489E, 493F, 494I, 495P, 496T, 497E, 498I, 499G, 500Y, 501E, 502V, 503K, 504A, 505Q, 506L, 507E, 513I, 514M, 515N, 516V, 517K, 518F, 519T, 520A, 521E, 522L, 523E, 524N, 525E, 526L, 527D, 528G, 529V, 530E, 531L, 532G, 533T, 534E, 535D, 536W, 537I, 538S, 539L, 540L, 541H, 542R, 543F, 544Y, 545D, 546G, 547L, 548K, 549E
CDD
cd00186 (TOP1Ac)

474A

domain IV
449P, 450P, 451A, 452R, 453L, 454T, 455E, 456S, 457S, 458L, 459V, 460K, 461M, 462L, 463E, 464T, 465E, 466G, 467I, 468G, 469R, 470P, 471S, 472T, 473Y, 474A, 475T, 476I, 477I, 478E, 479T, 480L, 481K, 482K, 483R, 484E, 485Y, 486I, 487V, 488M, 489E, 493F, 494I, 495P, 496T, 497E, 498I, 499G, 500Y, 501E, 502V, 503K, 504A, 505Q, 506L, 507E, 513I, 514M, 515N, 516V, 517K, 518F, 519T, 520A, 521E, 522L, 523E, 524N, 525E, 526L, 527D, 528G, 529V, 530E, 531L, 532G, 533T, 534E, 535D, 536W, 537I, 538S, 539L, 540L, 541H, 542R, 543F, 544Y, 545D, 546G, 547L, 548K, 549E
CDD
cd00186 (TOP1Ac)

475T

domain IV
449P, 450P, 451A, 452R, 453L, 454T, 455E, 456S, 457S, 458L, 459V, 460K, 461M, 462L, 463E, 464T, 465E, 466G, 467I, 468G, 469R, 470P, 471S, 472T, 473Y, 474A, 475T, 476I, 477I, 478E, 479T, 480L, 481K, 482K, 483R, 484E, 485Y, 486I, 487V, 488M, 489E, 493F, 494I, 495P, 496T, 497E, 498I, 499G, 500Y, 501E, 502V, 503K, 504A, 505Q, 506L, 507E, 513I, 514M, 515N, 516V, 517K, 518F, 519T, 520A, 521E, 522L, 523E, 524N, 525E, 526L, 527D, 528G, 529V, 530E, 531L, 532G, 533T, 534E, 535D, 536W, 537I, 538S, 539L, 540L, 541H, 542R, 543F, 544Y, 545D, 546G, 547L, 548K, 549E
CDD
cd00186 (TOP1Ac)

476I

domain IV
449P, 450P, 451A, 452R, 453L, 454T, 455E, 456S, 457S, 458L, 459V, 460K, 461M, 462L, 463E, 464T, 465E, 466G, 467I, 468G, 469R, 470P, 471S, 472T, 473Y, 474A, 475T, 476I, 477I, 478E, 479T, 480L, 481K, 482K, 483R, 484E, 485Y, 486I, 487V, 488M, 489E, 493F, 494I, 495P, 496T, 497E, 498I, 499G, 500Y, 501E, 502V, 503K, 504A, 505Q, 506L, 507E, 513I, 514M, 515N, 516V, 517K, 518F, 519T, 520A, 521E, 522L, 523E, 524N, 525E, 526L, 527D, 528G, 529V, 530E, 531L, 532G, 533T, 534E, 535D, 536W, 537I, 538S, 539L, 540L, 541H, 542R, 543F, 544Y, 545D, 546G, 547L, 548K, 549E
CDD
cd00186 (TOP1Ac)

477I

domain IV
449P, 450P, 451A, 452R, 453L, 454T, 455E, 456S, 457S, 458L, 459V, 460K, 461M, 462L, 463E, 464T, 465E, 466G, 467I, 468G, 469R, 470P, 471S, 472T, 473Y, 474A, 475T, 476I, 477I, 478E, 479T, 480L, 481K, 482K, 483R, 484E, 485Y, 486I, 487V, 488M, 489E, 493F, 494I, 495P, 496T, 497E, 498I, 499G, 500Y, 501E, 502V, 503K, 504A, 505Q, 506L, 507E, 513I, 514M, 515N, 516V, 517K, 518F, 519T, 520A, 521E, 522L, 523E, 524N, 525E, 526L, 527D, 528G, 529V, 530E, 531L, 532G, 533T, 534E, 535D, 536W, 537I, 538S, 539L, 540L, 541H, 542R, 543F, 544Y, 545D, 546G, 547L, 548K, 549E
CDD
cd00186 (TOP1Ac)

478E

domain IV
449P, 450P, 451A, 452R, 453L, 454T, 455E, 456S, 457S, 458L, 459V, 460K, 461M, 462L, 463E, 464T, 465E, 466G, 467I, 468G, 469R, 470P, 471S, 472T, 473Y, 474A, 475T, 476I, 477I, 478E, 479T, 480L, 481K, 482K, 483R, 484E, 485Y, 486I, 487V, 488M, 489E, 493F, 494I, 495P, 496T, 497E, 498I, 499G, 500Y, 501E, 502V, 503K, 504A, 505Q, 506L, 507E, 513I, 514M, 515N, 516V, 517K, 518F, 519T, 520A, 521E, 522L, 523E, 524N, 525E, 526L, 527D, 528G, 529V, 530E, 531L, 532G, 533T, 534E, 535D, 536W, 537I, 538S, 539L, 540L, 541H, 542R, 543F, 544Y, 545D, 546G, 547L, 548K, 549E
CDD
cd00186 (TOP1Ac)

479T

domain IV
449P, 450P, 451A, 452R, 453L, 454T, 455E, 456S, 457S, 458L, 459V, 460K, 461M, 462L, 463E, 464T, 465E, 466G, 467I, 468G, 469R, 470P, 471S, 472T, 473Y, 474A, 475T, 476I, 477I, 478E, 479T, 480L, 481K, 482K, 483R, 484E, 485Y, 486I, 487V, 488M, 489E, 493F, 494I, 495P, 496T, 497E, 498I, 499G, 500Y, 501E, 502V, 503K, 504A, 505Q, 506L, 507E, 513I, 514M, 515N, 516V, 517K, 518F, 519T, 520A, 521E, 522L, 523E, 524N, 525E, 526L, 527D, 528G, 529V, 530E, 531L, 532G, 533T, 534E, 535D, 536W, 537I, 538S, 539L, 540L, 541H, 542R, 543F, 544Y, 545D, 546G, 547L, 548K, 549E
CDD
cd00186 (TOP1Ac)

480L

domain IV
449P, 450P, 451A, 452R, 453L, 454T, 455E, 456S, 457S, 458L, 459V, 460K, 461M, 462L, 463E, 464T, 465E, 466G, 467I, 468G, 469R, 470P, 471S, 472T, 473Y, 474A, 475T, 476I, 477I, 478E, 479T, 480L, 481K, 482K, 483R, 484E, 485Y, 486I, 487V, 488M, 489E, 493F, 494I, 495P, 496T, 497E, 498I, 499G, 500Y, 501E, 502V, 503K, 504A, 505Q, 506L, 507E, 513I, 514M, 515N, 516V, 517K, 518F, 519T, 520A, 521E, 522L, 523E, 524N, 525E, 526L, 527D, 528G, 529V, 530E, 531L, 532G, 533T, 534E, 535D, 536W, 537I, 538S, 539L, 540L, 541H, 542R, 543F, 544Y, 545D, 546G, 547L, 548K, 549E
CDD
cd00186 (TOP1Ac)

481K

domain IV
449P, 450P, 451A, 452R, 453L, 454T, 455E, 456S, 457S, 458L, 459V, 460K, 461M, 462L, 463E, 464T, 465E, 466G, 467I, 468G, 469R, 470P, 471S, 472T, 473Y, 474A, 475T, 476I, 477I, 478E, 479T, 480L, 481K, 482K, 483R, 484E, 485Y, 486I, 487V, 488M, 489E, 493F, 494I, 495P, 496T, 497E, 498I, 499G, 500Y, 501E, 502V, 503K, 504A, 505Q, 506L, 507E, 513I, 514M, 515N, 516V, 517K, 518F, 519T, 520A, 521E, 522L, 523E, 524N, 525E, 526L, 527D, 528G, 529V, 530E, 531L, 532G, 533T, 534E, 535D, 536W, 537I, 538S, 539L, 540L, 541H, 542R, 543F, 544Y, 545D, 546G, 547L, 548K, 549E
CDD
cd00186 (TOP1Ac)

482K

domain IV
449P, 450P, 451A, 452R, 453L, 454T, 455E, 456S, 457S, 458L, 459V, 460K, 461M, 462L, 463E, 464T, 465E, 466G, 467I, 468G, 469R, 470P, 471S, 472T, 473Y, 474A, 475T, 476I, 477I, 478E, 479T, 480L, 481K, 482K, 483R, 484E, 485Y, 486I, 487V, 488M, 489E, 493F, 494I, 495P, 496T, 497E, 498I, 499G, 500Y, 501E, 502V, 503K, 504A, 505Q, 506L, 507E, 513I, 514M, 515N, 516V, 517K, 518F, 519T, 520A, 521E, 522L, 523E, 524N, 525E, 526L, 527D, 528G, 529V, 530E, 531L, 532G, 533T, 534E, 535D, 536W, 537I, 538S, 539L, 540L, 541H, 542R, 543F, 544Y, 545D, 546G, 547L, 548K, 549E
CDD
cd00186 (TOP1Ac)

483R

domain IV
449P, 450P, 451A, 452R, 453L, 454T, 455E, 456S, 457S, 458L, 459V, 460K, 461M, 462L, 463E, 464T, 465E, 466G, 467I, 468G, 469R, 470P, 471S, 472T, 473Y, 474A, 475T, 476I, 477I, 478E, 479T, 480L, 481K, 482K, 483R, 484E, 485Y, 486I, 487V, 488M, 489E, 493F, 494I, 495P, 496T, 497E, 498I, 499G, 500Y, 501E, 502V, 503K, 504A, 505Q, 506L, 507E, 513I, 514M, 515N, 516V, 517K, 518F, 519T, 520A, 521E, 522L, 523E, 524N, 525E, 526L, 527D, 528G, 529V, 530E, 531L, 532G, 533T, 534E, 535D, 536W, 537I, 538S, 539L, 540L, 541H, 542R, 543F, 544Y, 545D, 546G, 547L, 548K, 549E
CDD
cd00186 (TOP1Ac)

484E

domain IV
449P, 450P, 451A, 452R, 453L, 454T, 455E, 456S, 457S, 458L, 459V, 460K, 461M, 462L, 463E, 464T, 465E, 466G, 467I, 468G, 469R, 470P, 471S, 472T, 473Y, 474A, 475T, 476I, 477I, 478E, 479T, 480L, 481K, 482K, 483R, 484E, 485Y, 486I, 487V, 488M, 489E, 493F, 494I, 495P, 496T, 497E, 498I, 499G, 500Y, 501E, 502V, 503K, 504A, 505Q, 506L, 507E, 513I, 514M, 515N, 516V, 517K, 518F, 519T, 520A, 521E, 522L, 523E, 524N, 525E, 526L, 527D, 528G, 529V, 530E, 531L, 532G, 533T, 534E, 535D, 536W, 537I, 538S, 539L, 540L, 541H, 542R, 543F, 544Y, 545D, 546G, 547L, 548K, 549E
CDD
cd00186 (TOP1Ac)

485Y

domain IV
449P, 450P, 451A, 452R, 453L, 454T, 455E, 456S, 457S, 458L, 459V, 460K, 461M, 462L, 463E, 464T, 465E, 466G, 467I, 468G, 469R, 470P, 471S, 472T, 473Y, 474A, 475T, 476I, 477I, 478E, 479T, 480L, 481K, 482K, 483R, 484E, 485Y, 486I, 487V, 488M, 489E, 493F, 494I, 495P, 496T, 497E, 498I, 499G, 500Y, 501E, 502V, 503K, 504A, 505Q, 506L, 507E, 513I, 514M, 515N, 516V, 517K, 518F, 519T, 520A, 521E, 522L, 523E, 524N, 525E, 526L, 527D, 528G, 529V, 530E, 531L, 532G, 533T, 534E, 535D, 536W, 537I, 538S, 539L, 540L, 541H, 542R, 543F, 544Y, 545D, 546G, 547L, 548K, 549E
CDD
cd00186 (TOP1Ac)

486I

domain IV
449P, 450P, 451A, 452R, 453L, 454T, 455E, 456S, 457S, 458L, 459V, 460K, 461M, 462L, 463E, 464T, 465E, 466G, 467I, 468G, 469R, 470P, 471S, 472T, 473Y, 474A, 475T, 476I, 477I, 478E, 479T, 480L, 481K, 482K, 483R, 484E, 485Y, 486I, 487V, 488M, 489E, 493F, 494I, 495P, 496T, 497E, 498I, 499G, 500Y, 501E, 502V, 503K, 504A, 505Q, 506L, 507E, 513I, 514M, 515N, 516V, 517K, 518F, 519T, 520A, 521E, 522L, 523E, 524N, 525E, 526L, 527D, 528G, 529V, 530E, 531L, 532G, 533T, 534E, 535D, 536W, 537I, 538S, 539L, 540L, 541H, 542R, 543F, 544Y, 545D, 546G, 547L, 548K, 549E
CDD
cd00186 (TOP1Ac)

487V

domain IV
449P, 450P, 451A, 452R, 453L, 454T, 455E, 456S, 457S, 458L, 459V, 460K, 461M, 462L, 463E, 464T, 465E, 466G, 467I, 468G, 469R, 470P, 471S, 472T, 473Y, 474A, 475T, 476I, 477I, 478E, 479T, 480L, 481K, 482K, 483R, 484E, 485Y, 486I, 487V, 488M, 489E, 493F, 494I, 495P, 496T, 497E, 498I, 499G, 500Y, 501E, 502V, 503K, 504A, 505Q, 506L, 507E, 513I, 514M, 515N, 516V, 517K, 518F, 519T, 520A, 521E, 522L, 523E, 524N, 525E, 526L, 527D, 528G, 529V, 530E, 531L, 532G, 533T, 534E, 535D, 536W, 537I, 538S, 539L, 540L, 541H, 542R, 543F, 544Y, 545D, 546G, 547L, 548K, 549E
CDD
cd00186 (TOP1Ac)

488M

domain IV
449P, 450P, 451A, 452R, 453L, 454T, 455E, 456S, 457S, 458L, 459V, 460K, 461M, 462L, 463E, 464T, 465E, 466G, 467I, 468G, 469R, 470P, 471S, 472T, 473Y, 474A, 475T, 476I, 477I, 478E, 479T, 480L, 481K, 482K, 483R, 484E, 485Y, 486I, 487V, 488M, 489E, 493F, 494I, 495P, 496T, 497E, 498I, 499G, 500Y, 501E, 502V, 503K, 504A, 505Q, 506L, 507E, 513I, 514M, 515N, 516V, 517K, 518F, 519T, 520A, 521E, 522L, 523E, 524N, 525E, 526L, 527D, 528G, 529V, 530E, 531L, 532G, 533T, 534E, 535D, 536W, 537I, 538S, 539L, 540L, 541H, 542R, 543F, 544Y, 545D, 546G, 547L, 548K, 549E
CDD
cd00186 (TOP1Ac)

489E

domain IV
449P, 450P, 451A, 452R, 453L, 454T, 455E, 456S, 457S, 458L, 459V, 460K, 461M, 462L, 463E, 464T, 465E, 466G, 467I, 468G, 469R, 470P, 471S, 472T, 473Y, 474A, 475T, 476I, 477I, 478E, 479T, 480L, 481K, 482K, 483R, 484E, 485Y, 486I, 487V, 488M, 489E, 493F, 494I, 495P, 496T, 497E, 498I, 499G, 500Y, 501E, 502V, 503K, 504A, 505Q, 506L, 507E, 513I, 514M, 515N, 516V, 517K, 518F, 519T, 520A, 521E, 522L, 523E, 524N, 525E, 526L, 527D, 528G, 529V, 530E, 531L, 532G, 533T, 534E, 535D, 536W, 537I, 538S, 539L, 540L, 541H, 542R, 543F, 544Y, 545D, 546G, 547L, 548K, 549E
CDD
cd00186 (TOP1Ac)

493F

domain IV
449P, 450P, 451A, 452R, 453L, 454T, 455E, 456S, 457S, 458L, 459V, 460K, 461M, 462L, 463E, 464T, 465E, 466G, 467I, 468G, 469R, 470P, 471S, 472T, 473Y, 474A, 475T, 476I, 477I, 478E, 479T, 480L, 481K, 482K, 483R, 484E, 485Y, 486I, 487V, 488M, 489E, 493F, 494I, 495P, 496T, 497E, 498I, 499G, 500Y, 501E, 502V, 503K, 504A, 505Q, 506L, 507E, 513I, 514M, 515N, 516V, 517K, 518F, 519T, 520A, 521E, 522L, 523E, 524N, 525E, 526L, 527D, 528G, 529V, 530E, 531L, 532G, 533T, 534E, 535D, 536W, 537I, 538S, 539L, 540L, 541H, 542R, 543F, 544Y, 545D, 546G, 547L, 548K, 549E
CDD
cd00186 (TOP1Ac)

494I

domain IV
449P, 450P, 451A, 452R, 453L, 454T, 455E, 456S, 457S, 458L, 459V, 460K, 461M, 462L, 463E, 464T, 465E, 466G, 467I, 468G, 469R, 470P, 471S, 472T, 473Y, 474A, 475T, 476I, 477I, 478E, 479T, 480L, 481K, 482K, 483R, 484E, 485Y, 486I, 487V, 488M, 489E, 493F, 494I, 495P, 496T, 497E, 498I, 499G, 500Y, 501E, 502V, 503K, 504A, 505Q, 506L, 507E, 513I, 514M, 515N, 516V, 517K, 518F, 519T, 520A, 521E, 522L, 523E, 524N, 525E, 526L, 527D, 528G, 529V, 530E, 531L, 532G, 533T, 534E, 535D, 536W, 537I, 538S, 539L, 540L, 541H, 542R, 543F, 544Y, 545D, 546G, 547L, 548K, 549E
CDD
cd00186 (TOP1Ac)

495P

domain IV
449P, 450P, 451A, 452R, 453L, 454T, 455E, 456S, 457S, 458L, 459V, 460K, 461M, 462L, 463E, 464T, 465E, 466G, 467I, 468G, 469R, 470P, 471S, 472T, 473Y, 474A, 475T, 476I, 477I, 478E, 479T, 480L, 481K, 482K, 483R, 484E, 485Y, 486I, 487V, 488M, 489E, 493F, 494I, 495P, 496T, 497E, 498I, 499G, 500Y, 501E, 502V, 503K, 504A, 505Q, 506L, 507E, 513I, 514M, 515N, 516V, 517K, 518F, 519T, 520A, 521E, 522L, 523E, 524N, 525E, 526L, 527D, 528G, 529V, 530E, 531L, 532G, 533T, 534E, 535D, 536W, 537I, 538S, 539L, 540L, 541H, 542R, 543F, 544Y, 545D, 546G, 547L, 548K, 549E
CDD
cd00186 (TOP1Ac)

496T

domain IV
449P, 450P, 451A, 452R, 453L, 454T, 455E, 456S, 457S, 458L, 459V, 460K, 461M, 462L, 463E, 464T, 465E, 466G, 467I, 468G, 469R, 470P, 471S, 472T, 473Y, 474A, 475T, 476I, 477I, 478E, 479T, 480L, 481K, 482K, 483R, 484E, 485Y, 486I, 487V, 488M, 489E, 493F, 494I, 495P, 496T, 497E, 498I, 499G, 500Y, 501E, 502V, 503K, 504A, 505Q, 506L, 507E, 513I, 514M, 515N, 516V, 517K, 518F, 519T, 520A, 521E, 522L, 523E, 524N, 525E, 526L, 527D, 528G, 529V, 530E, 531L, 532G, 533T, 534E, 535D, 536W, 537I, 538S, 539L, 540L, 541H, 542R, 543F, 544Y, 545D, 546G, 547L, 548K, 549E
CDD
cd00186 (TOP1Ac)

497E

domain IV
449P, 450P, 451A, 452R, 453L, 454T, 455E, 456S, 457S, 458L, 459V, 460K, 461M, 462L, 463E, 464T, 465E, 466G, 467I, 468G, 469R, 470P, 471S, 472T, 473Y, 474A, 475T, 476I, 477I, 478E, 479T, 480L, 481K, 482K, 483R, 484E, 485Y, 486I, 487V, 488M, 489E, 493F, 494I, 495P, 496T, 497E, 498I, 499G, 500Y, 501E, 502V, 503K, 504A, 505Q, 506L, 507E, 513I, 514M, 515N, 516V, 517K, 518F, 519T, 520A, 521E, 522L, 523E, 524N, 525E, 526L, 527D, 528G, 529V, 530E, 531L, 532G, 533T, 534E, 535D, 536W, 537I, 538S, 539L, 540L, 541H, 542R, 543F, 544Y, 545D, 546G, 547L, 548K, 549E
CDD
cd00186 (TOP1Ac)

498I

domain IV
449P, 450P, 451A, 452R, 453L, 454T, 455E, 456S, 457S, 458L, 459V, 460K, 461M, 462L, 463E, 464T, 465E, 466G, 467I, 468G, 469R, 470P, 471S, 472T, 473Y, 474A, 475T, 476I, 477I, 478E, 479T, 480L, 481K, 482K, 483R, 484E, 485Y, 486I, 487V, 488M, 489E, 493F, 494I, 495P, 496T, 497E, 498I, 499G, 500Y, 501E, 502V, 503K, 504A, 505Q, 506L, 507E, 513I, 514M, 515N, 516V, 517K, 518F, 519T, 520A, 521E, 522L, 523E, 524N, 525E, 526L, 527D, 528G, 529V, 530E, 531L, 532G, 533T, 534E, 535D, 536W, 537I, 538S, 539L, 540L, 541H, 542R, 543F, 544Y, 545D, 546G, 547L, 548K, 549E
CDD
cd00186 (TOP1Ac)

499G

domain IV
449P, 450P, 451A, 452R, 453L, 454T, 455E, 456S, 457S, 458L, 459V, 460K, 461M, 462L, 463E, 464T, 465E, 466G, 467I, 468G, 469R, 470P, 471S, 472T, 473Y, 474A, 475T, 476I, 477I, 478E, 479T, 480L, 481K, 482K, 483R, 484E, 485Y, 486I, 487V, 488M, 489E, 493F, 494I, 495P, 496T, 497E, 498I, 499G, 500Y, 501E, 502V, 503K, 504A, 505Q, 506L, 507E, 513I, 514M, 515N, 516V, 517K, 518F, 519T, 520A, 521E, 522L, 523E, 524N, 525E, 526L, 527D, 528G, 529V, 530E, 531L, 532G, 533T, 534E, 535D, 536W, 537I, 538S, 539L, 540L, 541H, 542R, 543F, 544Y, 545D, 546G, 547L, 548K, 549E
CDD
cd00186 (TOP1Ac)

500Y

domain IV
449P, 450P, 451A, 452R, 453L, 454T, 455E, 456S, 457S, 458L, 459V, 460K, 461M, 462L, 463E, 464T, 465E, 466G, 467I, 468G, 469R, 470P, 471S, 472T, 473Y, 474A, 475T, 476I, 477I, 478E, 479T, 480L, 481K, 482K, 483R, 484E, 485Y, 486I, 487V, 488M, 489E, 493F, 494I, 495P, 496T, 497E, 498I, 499G, 500Y, 501E, 502V, 503K, 504A, 505Q, 506L, 507E, 513I, 514M, 515N, 516V, 517K, 518F, 519T, 520A, 521E, 522L, 523E, 524N, 525E, 526L, 527D, 528G, 529V, 530E, 531L, 532G, 533T, 534E, 535D, 536W, 537I, 538S, 539L, 540L, 541H, 542R, 543F, 544Y, 545D, 546G, 547L, 548K, 549E
CDD
cd00186 (TOP1Ac)

501E

domain IV
449P, 450P, 451A, 452R, 453L, 454T, 455E, 456S, 457S, 458L, 459V, 460K, 461M, 462L, 463E, 464T, 465E, 466G, 467I, 468G, 469R, 470P, 471S, 472T, 473Y, 474A, 475T, 476I, 477I, 478E, 479T, 480L, 481K, 482K, 483R, 484E, 485Y, 486I, 487V, 488M, 489E, 493F, 494I, 495P, 496T, 497E, 498I, 499G, 500Y, 501E, 502V, 503K, 504A, 505Q, 506L, 507E, 513I, 514M, 515N, 516V, 517K, 518F, 519T, 520A, 521E, 522L, 523E, 524N, 525E, 526L, 527D, 528G, 529V, 530E, 531L, 532G, 533T, 534E, 535D, 536W, 537I, 538S, 539L, 540L, 541H, 542R, 543F, 544Y, 545D, 546G, 547L, 548K, 549E
CDD
cd00186 (TOP1Ac)

502V

domain IV
449P, 450P, 451A, 452R, 453L, 454T, 455E, 456S, 457S, 458L, 459V, 460K, 461M, 462L, 463E, 464T, 465E, 466G, 467I, 468G, 469R, 470P, 471S, 472T, 473Y, 474A, 475T, 476I, 477I, 478E, 479T, 480L, 481K, 482K, 483R, 484E, 485Y, 486I, 487V, 488M, 489E, 493F, 494I, 495P, 496T, 497E, 498I, 499G, 500Y, 501E, 502V, 503K, 504A, 505Q, 506L, 507E, 513I, 514M, 515N, 516V, 517K, 518F, 519T, 520A, 521E, 522L, 523E, 524N, 525E, 526L, 527D, 528G, 529V, 530E, 531L, 532G, 533T, 534E, 535D, 536W, 537I, 538S, 539L, 540L, 541H, 542R, 543F, 544Y, 545D, 546G, 547L, 548K, 549E
CDD
cd00186 (TOP1Ac)

503K

domain IV
449P, 450P, 451A, 452R, 453L, 454T, 455E, 456S, 457S, 458L, 459V, 460K, 461M, 462L, 463E, 464T, 465E, 466G, 467I, 468G, 469R, 470P, 471S, 472T, 473Y, 474A, 475T, 476I, 477I, 478E, 479T, 480L, 481K, 482K, 483R, 484E, 485Y, 486I, 487V, 488M, 489E, 493F, 494I, 495P, 496T, 497E, 498I, 499G, 500Y, 501E, 502V, 503K, 504A, 505Q, 506L, 507E, 513I, 514M, 515N, 516V, 517K, 518F, 519T, 520A, 521E, 522L, 523E, 524N, 525E, 526L, 527D, 528G, 529V, 530E, 531L, 532G, 533T, 534E, 535D, 536W, 537I, 538S, 539L, 540L, 541H, 542R, 543F, 544Y, 545D, 546G, 547L, 548K, 549E
CDD
cd00186 (TOP1Ac)

504A

domain IV
449P, 450P, 451A, 452R, 453L, 454T, 455E, 456S, 457S, 458L, 459V, 460K, 461M, 462L, 463E, 464T, 465E, 466G, 467I, 468G, 469R, 470P, 471S, 472T, 473Y, 474A, 475T, 476I, 477I, 478E, 479T, 480L, 481K, 482K, 483R, 484E, 485Y, 486I, 487V, 488M, 489E, 493F, 494I, 495P, 496T, 497E, 498I, 499G, 500Y, 501E, 502V, 503K, 504A, 505Q, 506L, 507E, 513I, 514M, 515N, 516V, 517K, 518F, 519T, 520A, 521E, 522L, 523E, 524N, 525E, 526L, 527D, 528G, 529V, 530E, 531L, 532G, 533T, 534E, 535D, 536W, 537I, 538S, 539L, 540L, 541H, 542R, 543F, 544Y, 545D, 546G, 547L, 548K, 549E
CDD
cd00186 (TOP1Ac)

505Q

domain IV
449P, 450P, 451A, 452R, 453L, 454T, 455E, 456S, 457S, 458L, 459V, 460K, 461M, 462L, 463E, 464T, 465E, 466G, 467I, 468G, 469R, 470P, 471S, 472T, 473Y, 474A, 475T, 476I, 477I, 478E, 479T, 480L, 481K, 482K, 483R, 484E, 485Y, 486I, 487V, 488M, 489E, 493F, 494I, 495P, 496T, 497E, 498I, 499G, 500Y, 501E, 502V, 503K, 504A, 505Q, 506L, 507E, 513I, 514M, 515N, 516V, 517K, 518F, 519T, 520A, 521E, 522L, 523E, 524N, 525E, 526L, 527D, 528G, 529V, 530E, 531L, 532G, 533T, 534E, 535D, 536W, 537I, 538S, 539L, 540L, 541H, 542R, 543F, 544Y, 545D, 546G, 547L, 548K, 549E
CDD
cd00186 (TOP1Ac)

506L

domain IV
449P, 450P, 451A, 452R, 453L, 454T, 455E, 456S, 457S, 458L, 459V, 460K, 461M, 462L, 463E, 464T, 465E, 466G, 467I, 468G, 469R, 470P, 471S, 472T, 473Y, 474A, 475T, 476I, 477I, 478E, 479T, 480L, 481K, 482K, 483R, 484E, 485Y, 486I, 487V, 488M, 489E, 493F, 494I, 495P, 496T, 497E, 498I, 499G, 500Y, 501E, 502V, 503K, 504A, 505Q, 506L, 507E, 513I, 514M, 515N, 516V, 517K, 518F, 519T, 520A, 521E, 522L, 523E, 524N, 525E, 526L, 527D, 528G, 529V, 530E, 531L, 532G, 533T, 534E, 535D, 536W, 537I, 538S, 539L, 540L, 541H, 542R, 543F, 544Y, 545D, 546G, 547L, 548K, 549E
CDD
cd00186 (TOP1Ac)

507E

domain IV
449P, 450P, 451A, 452R, 453L, 454T, 455E, 456S, 457S, 458L, 459V, 460K, 461M, 462L, 463E, 464T, 465E, 466G, 467I, 468G, 469R, 470P, 471S, 472T, 473Y, 474A, 475T, 476I, 477I, 478E, 479T, 480L, 481K, 482K, 483R, 484E, 485Y, 486I, 487V, 488M, 489E, 493F, 494I, 495P, 496T, 497E, 498I, 499G, 500Y, 501E, 502V, 503K, 504A, 505Q, 506L, 507E, 513I, 514M, 515N, 516V, 517K, 518F, 519T, 520A, 521E, 522L, 523E, 524N, 525E, 526L, 527D, 528G, 529V, 530E, 531L, 532G, 533T, 534E, 535D, 536W, 537I, 538S, 539L, 540L, 541H, 542R, 543F, 544Y, 545D, 546G, 547L, 548K, 549E
CDD
cd00186 (TOP1Ac)

513I

domain IV
449P, 450P, 451A, 452R, 453L, 454T, 455E, 456S, 457S, 458L, 459V, 460K, 461M, 462L, 463E, 464T, 465E, 466G, 467I, 468G, 469R, 470P, 471S, 472T, 473Y, 474A, 475T, 476I, 477I, 478E, 479T, 480L, 481K, 482K, 483R, 484E, 485Y, 486I, 487V, 488M, 489E, 493F, 494I, 495P, 496T, 497E, 498I, 499G, 500Y, 501E, 502V, 503K, 504A, 505Q, 506L, 507E, 513I, 514M, 515N, 516V, 517K, 518F, 519T, 520A, 521E, 522L, 523E, 524N, 525E, 526L, 527D, 528G, 529V, 530E, 531L, 532G, 533T, 534E, 535D, 536W, 537I, 538S, 539L, 540L, 541H, 542R, 543F, 544Y, 545D, 546G, 547L, 548K, 549E
CDD
cd00186 (TOP1Ac)

514M

domain IV
449P, 450P, 451A, 452R, 453L, 454T, 455E, 456S, 457S, 458L, 459V, 460K, 461M, 462L, 463E, 464T, 465E, 466G, 467I, 468G, 469R, 470P, 471S, 472T, 473Y, 474A, 475T, 476I, 477I, 478E, 479T, 480L, 481K, 482K, 483R, 484E, 485Y, 486I, 487V, 488M, 489E, 493F, 494I, 495P, 496T, 497E, 498I, 499G, 500Y, 501E, 502V, 503K, 504A, 505Q, 506L, 507E, 513I, 514M, 515N, 516V, 517K, 518F, 519T, 520A, 521E, 522L, 523E, 524N, 525E, 526L, 527D, 528G, 529V, 530E, 531L, 532G, 533T, 534E, 535D, 536W, 537I, 538S, 539L, 540L, 541H, 542R, 543F, 544Y, 545D, 546G, 547L, 548K, 549E
CDD
cd00186 (TOP1Ac)

515N

domain IV
449P, 450P, 451A, 452R, 453L, 454T, 455E, 456S, 457S, 458L, 459V, 460K, 461M, 462L, 463E, 464T, 465E, 466G, 467I, 468G, 469R, 470P, 471S, 472T, 473Y, 474A, 475T, 476I, 477I, 478E, 479T, 480L, 481K, 482K, 483R, 484E, 485Y, 486I, 487V, 488M, 489E, 493F, 494I, 495P, 496T, 497E, 498I, 499G, 500Y, 501E, 502V, 503K, 504A, 505Q, 506L, 507E, 513I, 514M, 515N, 516V, 517K, 518F, 519T, 520A, 521E, 522L, 523E, 524N, 525E, 526L, 527D, 528G, 529V, 530E, 531L, 532G, 533T, 534E, 535D, 536W, 537I, 538S, 539L, 540L, 541H, 542R, 543F, 544Y, 545D, 546G, 547L, 548K, 549E
CDD
cd00186 (TOP1Ac)

516V

domain IV
449P, 450P, 451A, 452R, 453L, 454T, 455E, 456S, 457S, 458L, 459V, 460K, 461M, 462L, 463E, 464T, 465E, 466G, 467I, 468G, 469R, 470P, 471S, 472T, 473Y, 474A, 475T, 476I, 477I, 478E, 479T, 480L, 481K, 482K, 483R, 484E, 485Y, 486I, 487V, 488M, 489E, 493F, 494I, 495P, 496T, 497E, 498I, 499G, 500Y, 501E, 502V, 503K, 504A, 505Q, 506L, 507E, 513I, 514M, 515N, 516V, 517K, 518F, 519T, 520A, 521E, 522L, 523E, 524N, 525E, 526L, 527D, 528G, 529V, 530E, 531L, 532G, 533T, 534E, 535D, 536W, 537I, 538S, 539L, 540L, 541H, 542R, 543F, 544Y, 545D, 546G, 547L, 548K, 549E
CDD
cd00186 (TOP1Ac)

517K

domain IV
449P, 450P, 451A, 452R, 453L, 454T, 455E, 456S, 457S, 458L, 459V, 460K, 461M, 462L, 463E, 464T, 465E, 466G, 467I, 468G, 469R, 470P, 471S, 472T, 473Y, 474A, 475T, 476I, 477I, 478E, 479T, 480L, 481K, 482K, 483R, 484E, 485Y, 486I, 487V, 488M, 489E, 493F, 494I, 495P, 496T, 497E, 498I, 499G, 500Y, 501E, 502V, 503K, 504A, 505Q, 506L, 507E, 513I, 514M, 515N, 516V, 517K, 518F, 519T, 520A, 521E, 522L, 523E, 524N, 525E, 526L, 527D, 528G, 529V, 530E, 531L, 532G, 533T, 534E, 535D, 536W, 537I, 538S, 539L, 540L, 541H, 542R, 543F, 544Y, 545D, 546G, 547L, 548K, 549E
CDD
cd00186 (TOP1Ac)

518F

domain IV
449P, 450P, 451A, 452R, 453L, 454T, 455E, 456S, 457S, 458L, 459V, 460K, 461M, 462L, 463E, 464T, 465E, 466G, 467I, 468G, 469R, 470P, 471S, 472T, 473Y, 474A, 475T, 476I, 477I, 478E, 479T, 480L, 481K, 482K, 483R, 484E, 485Y, 486I, 487V, 488M, 489E, 493F, 494I, 495P, 496T, 497E, 498I, 499G, 500Y, 501E, 502V, 503K, 504A, 505Q, 506L, 507E, 513I, 514M, 515N, 516V, 517K, 518F, 519T, 520A, 521E, 522L, 523E, 524N, 525E, 526L, 527D, 528G, 529V, 530E, 531L, 532G, 533T, 534E, 535D, 536W, 537I, 538S, 539L, 540L, 541H, 542R, 543F, 544Y, 545D, 546G, 547L, 548K, 549E
CDD
cd00186 (TOP1Ac)

519T

domain IV
449P, 450P, 451A, 452R, 453L, 454T, 455E, 456S, 457S, 458L, 459V, 460K, 461M, 462L, 463E, 464T, 465E, 466G, 467I, 468G, 469R, 470P, 471S, 472T, 473Y, 474A, 475T, 476I, 477I, 478E, 479T, 480L, 481K, 482K, 483R, 484E, 485Y, 486I, 487V, 488M, 489E, 493F, 494I, 495P, 496T, 497E, 498I, 499G, 500Y, 501E, 502V, 503K, 504A, 505Q, 506L, 507E, 513I, 514M, 515N, 516V, 517K, 518F, 519T, 520A, 521E, 522L, 523E, 524N, 525E, 526L, 527D, 528G, 529V, 530E, 531L, 532G, 533T, 534E, 535D, 536W, 537I, 538S, 539L, 540L, 541H, 542R, 543F, 544Y, 545D, 546G, 547L, 548K, 549E
CDD
cd00186 (TOP1Ac)

520A

domain IV
449P, 450P, 451A, 452R, 453L, 454T, 455E, 456S, 457S, 458L, 459V, 460K, 461M, 462L, 463E, 464T, 465E, 466G, 467I, 468G, 469R, 470P, 471S, 472T, 473Y, 474A, 475T, 476I, 477I, 478E, 479T, 480L, 481K, 482K, 483R, 484E, 485Y, 486I, 487V, 488M, 489E, 493F, 494I, 495P, 496T, 497E, 498I, 499G, 500Y, 501E, 502V, 503K, 504A, 505Q, 506L, 507E, 513I, 514M, 515N, 516V, 517K, 518F, 519T, 520A, 521E, 522L, 523E, 524N, 525E, 526L, 527D, 528G, 529V, 530E, 531L, 532G, 533T, 534E, 535D, 536W, 537I, 538S, 539L, 540L, 541H, 542R, 543F, 544Y, 545D, 546G, 547L, 548K, 549E
CDD
cd00186 (TOP1Ac)

521E

domain IV
449P, 450P, 451A, 452R, 453L, 454T, 455E, 456S, 457S, 458L, 459V, 460K, 461M, 462L, 463E, 464T, 465E, 466G, 467I, 468G, 469R, 470P, 471S, 472T, 473Y, 474A, 475T, 476I, 477I, 478E, 479T, 480L, 481K, 482K, 483R, 484E, 485Y, 486I, 487V, 488M, 489E, 493F, 494I, 495P, 496T, 497E, 498I, 499G, 500Y, 501E, 502V, 503K, 504A, 505Q, 506L, 507E, 513I, 514M, 515N, 516V, 517K, 518F, 519T, 520A, 521E, 522L, 523E, 524N, 525E, 526L, 527D, 528G, 529V, 530E, 531L, 532G, 533T, 534E, 535D, 536W, 537I, 538S, 539L, 540L, 541H, 542R, 543F, 544Y, 545D, 546G, 547L, 548K, 549E
CDD
cd00186 (TOP1Ac)

522L

domain IV
449P, 450P, 451A, 452R, 453L, 454T, 455E, 456S, 457S, 458L, 459V, 460K, 461M, 462L, 463E, 464T, 465E, 466G, 467I, 468G, 469R, 470P, 471S, 472T, 473Y, 474A, 475T, 476I, 477I, 478E, 479T, 480L, 481K, 482K, 483R, 484E, 485Y, 486I, 487V, 488M, 489E, 493F, 494I, 495P, 496T, 497E, 498I, 499G, 500Y, 501E, 502V, 503K, 504A, 505Q, 506L, 507E, 513I, 514M, 515N, 516V, 517K, 518F, 519T, 520A, 521E, 522L, 523E, 524N, 525E, 526L, 527D, 528G, 529V, 530E, 531L, 532G, 533T, 534E, 535D, 536W, 537I, 538S, 539L, 540L, 541H, 542R, 543F, 544Y, 545D, 546G, 547L, 548K, 549E
CDD
cd00186 (TOP1Ac)

523E

domain IV
449P, 450P, 451A, 452R, 453L, 454T, 455E, 456S, 457S, 458L, 459V, 460K, 461M, 462L, 463E, 464T, 465E, 466G, 467I, 468G, 469R, 470P, 471S, 472T, 473Y, 474A, 475T, 476I, 477I, 478E, 479T, 480L, 481K, 482K, 483R, 484E, 485Y, 486I, 487V, 488M, 489E, 493F, 494I, 495P, 496T, 497E, 498I, 499G, 500Y, 501E, 502V, 503K, 504A, 505Q, 506L, 507E, 513I, 514M, 515N, 516V, 517K, 518F, 519T, 520A, 521E, 522L, 523E, 524N, 525E, 526L, 527D, 528G, 529V, 530E, 531L, 532G, 533T, 534E, 535D, 536W, 537I, 538S, 539L, 540L, 541H, 542R, 543F, 544Y, 545D, 546G, 547L, 548K, 549E
CDD
cd00186 (TOP1Ac)

524N

domain IV
449P, 450P, 451A, 452R, 453L, 454T, 455E, 456S, 457S, 458L, 459V, 460K, 461M, 462L, 463E, 464T, 465E, 466G, 467I, 468G, 469R, 470P, 471S, 472T, 473Y, 474A, 475T, 476I, 477I, 478E, 479T, 480L, 481K, 482K, 483R, 484E, 485Y, 486I, 487V, 488M, 489E, 493F, 494I, 495P, 496T, 497E, 498I, 499G, 500Y, 501E, 502V, 503K, 504A, 505Q, 506L, 507E, 513I, 514M, 515N, 516V, 517K, 518F, 519T, 520A, 521E, 522L, 523E, 524N, 525E, 526L, 527D, 528G, 529V, 530E, 531L, 532G, 533T, 534E, 535D, 536W, 537I, 538S, 539L, 540L, 541H, 542R, 543F, 544Y, 545D, 546G, 547L, 548K, 549E
CDD
cd00186 (TOP1Ac)

525E

domain IV
449P, 450P, 451A, 452R, 453L, 454T, 455E, 456S, 457S, 458L, 459V, 460K, 461M, 462L, 463E, 464T, 465E, 466G, 467I, 468G, 469R, 470P, 471S, 472T, 473Y, 474A, 475T, 476I, 477I, 478E, 479T, 480L, 481K, 482K, 483R, 484E, 485Y, 486I, 487V, 488M, 489E, 493F, 494I, 495P, 496T, 497E, 498I, 499G, 500Y, 501E, 502V, 503K, 504A, 505Q, 506L, 507E, 513I, 514M, 515N, 516V, 517K, 518F, 519T, 520A, 521E, 522L, 523E, 524N, 525E, 526L, 527D, 528G, 529V, 530E, 531L, 532G, 533T, 534E, 535D, 536W, 537I, 538S, 539L, 540L, 541H, 542R, 543F, 544Y, 545D, 546G, 547L, 548K, 549E
CDD
cd00186 (TOP1Ac)

526L

domain IV
449P, 450P, 451A, 452R, 453L, 454T, 455E, 456S, 457S, 458L, 459V, 460K, 461M, 462L, 463E, 464T, 465E, 466G, 467I, 468G, 469R, 470P, 471S, 472T, 473Y, 474A, 475T, 476I, 477I, 478E, 479T, 480L, 481K, 482K, 483R, 484E, 485Y, 486I, 487V, 488M, 489E, 493F, 494I, 495P, 496T, 497E, 498I, 499G, 500Y, 501E, 502V, 503K, 504A, 505Q, 506L, 507E, 513I, 514M, 515N, 516V, 517K, 518F, 519T, 520A, 521E, 522L, 523E, 524N, 525E, 526L, 527D, 528G, 529V, 530E, 531L, 532G, 533T, 534E, 535D, 536W, 537I, 538S, 539L, 540L, 541H, 542R, 543F, 544Y, 545D, 546G, 547L, 548K, 549E
CDD
cd00186 (TOP1Ac)

527D

domain IV
449P, 450P, 451A, 452R, 453L, 454T, 455E, 456S, 457S, 458L, 459V, 460K, 461M, 462L, 463E, 464T, 465E, 466G, 467I, 468G, 469R, 470P, 471S, 472T, 473Y, 474A, 475T, 476I, 477I, 478E, 479T, 480L, 481K, 482K, 483R, 484E, 485Y, 486I, 487V, 488M, 489E, 493F, 494I, 495P, 496T, 497E, 498I, 499G, 500Y, 501E, 502V, 503K, 504A, 505Q, 506L, 507E, 513I, 514M, 515N, 516V, 517K, 518F, 519T, 520A, 521E, 522L, 523E, 524N, 525E, 526L, 527D, 528G, 529V, 530E, 531L, 532G, 533T, 534E, 535D, 536W, 537I, 538S, 539L, 540L, 541H, 542R, 543F, 544Y, 545D, 546G, 547L, 548K, 549E
CDD
cd00186 (TOP1Ac)

528G

domain IV
449P, 450P, 451A, 452R, 453L, 454T, 455E, 456S, 457S, 458L, 459V, 460K, 461M, 462L, 463E, 464T, 465E, 466G, 467I, 468G, 469R, 470P, 471S, 472T, 473Y, 474A, 475T, 476I, 477I, 478E, 479T, 480L, 481K, 482K, 483R, 484E, 485Y, 486I, 487V, 488M, 489E, 493F, 494I, 495P, 496T, 497E, 498I, 499G, 500Y, 501E, 502V, 503K, 504A, 505Q, 506L, 507E, 513I, 514M, 515N, 516V, 517K, 518F, 519T, 520A, 521E, 522L, 523E, 524N, 525E, 526L, 527D, 528G, 529V, 530E, 531L, 532G, 533T, 534E, 535D, 536W, 537I, 538S, 539L, 540L, 541H, 542R, 543F, 544Y, 545D, 546G, 547L, 548K, 549E
CDD
cd00186 (TOP1Ac)

529V

domain IV
449P, 450P, 451A, 452R, 453L, 454T, 455E, 456S, 457S, 458L, 459V, 460K, 461M, 462L, 463E, 464T, 465E, 466G, 467I, 468G, 469R, 470P, 471S, 472T, 473Y, 474A, 475T, 476I, 477I, 478E, 479T, 480L, 481K, 482K, 483R, 484E, 485Y, 486I, 487V, 488M, 489E, 493F, 494I, 495P, 496T, 497E, 498I, 499G, 500Y, 501E, 502V, 503K, 504A, 505Q, 506L, 507E, 513I, 514M, 515N, 516V, 517K, 518F, 519T, 520A, 521E, 522L, 523E, 524N, 525E, 526L, 527D, 528G, 529V, 530E, 531L, 532G, 533T, 534E, 535D, 536W, 537I, 538S, 539L, 540L, 541H, 542R, 543F, 544Y, 545D, 546G, 547L, 548K, 549E
CDD
cd00186 (TOP1Ac)

530E

domain IV
449P, 450P, 451A, 452R, 453L, 454T, 455E, 456S, 457S, 458L, 459V, 460K, 461M, 462L, 463E, 464T, 465E, 466G, 467I, 468G, 469R, 470P, 471S, 472T, 473Y, 474A, 475T, 476I, 477I, 478E, 479T, 480L, 481K, 482K, 483R, 484E, 485Y, 486I, 487V, 488M, 489E, 493F, 494I, 495P, 496T, 497E, 498I, 499G, 500Y, 501E, 502V, 503K, 504A, 505Q, 506L, 507E, 513I, 514M, 515N, 516V, 517K, 518F, 519T, 520A, 521E, 522L, 523E, 524N, 525E, 526L, 527D, 528G, 529V, 530E, 531L, 532G, 533T, 534E, 535D, 536W, 537I, 538S, 539L, 540L, 541H, 542R, 543F, 544Y, 545D, 546G, 547L, 548K, 549E
CDD
cd00186 (TOP1Ac)

531L

domain IV
449P, 450P, 451A, 452R, 453L, 454T, 455E, 456S, 457S, 458L, 459V, 460K, 461M, 462L, 463E, 464T, 465E, 466G, 467I, 468G, 469R, 470P, 471S, 472T, 473Y, 474A, 475T, 476I, 477I, 478E, 479T, 480L, 481K, 482K, 483R, 484E, 485Y, 486I, 487V, 488M, 489E, 493F, 494I, 495P, 496T, 497E, 498I, 499G, 500Y, 501E, 502V, 503K, 504A, 505Q, 506L, 507E, 513I, 514M, 515N, 516V, 517K, 518F, 519T, 520A, 521E, 522L, 523E, 524N, 525E, 526L, 527D, 528G, 529V, 530E, 531L, 532G, 533T, 534E, 535D, 536W, 537I, 538S, 539L, 540L, 541H, 542R, 543F, 544Y, 545D, 546G, 547L, 548K, 549E
CDD
cd00186 (TOP1Ac)

532G

domain IV
449P, 450P, 451A, 452R, 453L, 454T, 455E, 456S, 457S, 458L, 459V, 460K, 461M, 462L, 463E, 464T, 465E, 466G, 467I, 468G, 469R, 470P, 471S, 472T, 473Y, 474A, 475T, 476I, 477I, 478E, 479T, 480L, 481K, 482K, 483R, 484E, 485Y, 486I, 487V, 488M, 489E, 493F, 494I, 495P, 496T, 497E, 498I, 499G, 500Y, 501E, 502V, 503K, 504A, 505Q, 506L, 507E, 513I, 514M, 515N, 516V, 517K, 518F, 519T, 520A, 521E, 522L, 523E, 524N, 525E, 526L, 527D, 528G, 529V, 530E, 531L, 532G, 533T, 534E, 535D, 536W, 537I, 538S, 539L, 540L, 541H, 542R, 543F, 544Y, 545D, 546G, 547L, 548K, 549E
CDD
cd00186 (TOP1Ac)

533T

domain IV
449P, 450P, 451A, 452R, 453L, 454T, 455E, 456S, 457S, 458L, 459V, 460K, 461M, 462L, 463E, 464T, 465E, 466G, 467I, 468G, 469R, 470P, 471S, 472T, 473Y, 474A, 475T, 476I, 477I, 478E, 479T, 480L, 481K, 482K, 483R, 484E, 485Y, 486I, 487V, 488M, 489E, 493F, 494I, 495P, 496T, 497E, 498I, 499G, 500Y, 501E, 502V, 503K, 504A, 505Q, 506L, 507E, 513I, 514M, 515N, 516V, 517K, 518F, 519T, 520A, 521E, 522L, 523E, 524N, 525E, 526L, 527D, 528G, 529V, 530E, 531L, 532G, 533T, 534E, 535D, 536W, 537I, 538S, 539L, 540L, 541H, 542R, 543F, 544Y, 545D, 546G, 547L, 548K, 549E
CDD
cd00186 (TOP1Ac)

534E

domain IV
449P, 450P, 451A, 452R, 453L, 454T, 455E, 456S, 457S, 458L, 459V, 460K, 461M, 462L, 463E, 464T, 465E, 466G, 467I, 468G, 469R, 470P, 471S, 472T, 473Y, 474A, 475T, 476I, 477I, 478E, 479T, 480L, 481K, 482K, 483R, 484E, 485Y, 486I, 487V, 488M, 489E, 493F, 494I, 495P, 496T, 497E, 498I, 499G, 500Y, 501E, 502V, 503K, 504A, 505Q, 506L, 507E, 513I, 514M, 515N, 516V, 517K, 518F, 519T, 520A, 521E, 522L, 523E, 524N, 525E, 526L, 527D, 528G, 529V, 530E, 531L, 532G, 533T, 534E, 535D, 536W, 537I, 538S, 539L, 540L, 541H, 542R, 543F, 544Y, 545D, 546G, 547L, 548K, 549E
CDD
cd00186 (TOP1Ac)

535D

domain IV
449P, 450P, 451A, 452R, 453L, 454T, 455E, 456S, 457S, 458L, 459V, 460K, 461M, 462L, 463E, 464T, 465E, 466G, 467I, 468G, 469R, 470P, 471S, 472T, 473Y, 474A, 475T, 476I, 477I, 478E, 479T, 480L, 481K, 482K, 483R, 484E, 485Y, 486I, 487V, 488M, 489E, 493F, 494I, 495P, 496T, 497E, 498I, 499G, 500Y, 501E, 502V, 503K, 504A, 505Q, 506L, 507E, 513I, 514M, 515N, 516V, 517K, 518F, 519T, 520A, 521E, 522L, 523E, 524N, 525E, 526L, 527D, 528G, 529V, 530E, 531L, 532G, 533T, 534E, 535D, 536W, 537I, 538S, 539L, 540L, 541H, 542R, 543F, 544Y, 545D, 546G, 547L, 548K, 549E
CDD
cd00186 (TOP1Ac)

536W

domain IV
449P, 450P, 451A, 452R, 453L, 454T, 455E, 456S, 457S, 458L, 459V, 460K, 461M, 462L, 463E, 464T, 465E, 466G, 467I, 468G, 469R, 470P, 471S, 472T, 473Y, 474A, 475T, 476I, 477I, 478E, 479T, 480L, 481K, 482K, 483R, 484E, 485Y, 486I, 487V, 488M, 489E, 493F, 494I, 495P, 496T, 497E, 498I, 499G, 500Y, 501E, 502V, 503K, 504A, 505Q, 506L, 507E, 513I, 514M, 515N, 516V, 517K, 518F, 519T, 520A, 521E, 522L, 523E, 524N, 525E, 526L, 527D, 528G, 529V, 530E, 531L, 532G, 533T, 534E, 535D, 536W, 537I, 538S, 539L, 540L, 541H, 542R, 543F, 544Y, 545D, 546G, 547L, 548K, 549E
CDD
cd00186 (TOP1Ac)

537I

domain IV
449P, 450P, 451A, 452R, 453L, 454T, 455E, 456S, 457S, 458L, 459V, 460K, 461M, 462L, 463E, 464T, 465E, 466G, 467I, 468G, 469R, 470P, 471S, 472T, 473Y, 474A, 475T, 476I, 477I, 478E, 479T, 480L, 481K, 482K, 483R, 484E, 485Y, 486I, 487V, 488M, 489E, 493F, 494I, 495P, 496T, 497E, 498I, 499G, 500Y, 501E, 502V, 503K, 504A, 505Q, 506L, 507E, 513I, 514M, 515N, 516V, 517K, 518F, 519T, 520A, 521E, 522L, 523E, 524N, 525E, 526L, 527D, 528G, 529V, 530E, 531L, 532G, 533T, 534E, 535D, 536W, 537I, 538S, 539L, 540L, 541H, 542R, 543F, 544Y, 545D, 546G, 547L, 548K, 549E
CDD
cd00186 (TOP1Ac)

538S

domain IV
449P, 450P, 451A, 452R, 453L, 454T, 455E, 456S, 457S, 458L, 459V, 460K, 461M, 462L, 463E, 464T, 465E, 466G, 467I, 468G, 469R, 470P, 471S, 472T, 473Y, 474A, 475T, 476I, 477I, 478E, 479T, 480L, 481K, 482K, 483R, 484E, 485Y, 486I, 487V, 488M, 489E, 493F, 494I, 495P, 496T, 497E, 498I, 499G, 500Y, 501E, 502V, 503K, 504A, 505Q, 506L, 507E, 513I, 514M, 515N, 516V, 517K, 518F, 519T, 520A, 521E, 522L, 523E, 524N, 525E, 526L, 527D, 528G, 529V, 530E, 531L, 532G, 533T, 534E, 535D, 536W, 537I, 538S, 539L, 540L, 541H, 542R, 543F, 544Y, 545D, 546G, 547L, 548K, 549E
CDD
cd00186 (TOP1Ac)

539L

domain IV
449P, 450P, 451A, 452R, 453L, 454T, 455E, 456S, 457S, 458L, 459V, 460K, 461M, 462L, 463E, 464T, 465E, 466G, 467I, 468G, 469R, 470P, 471S, 472T, 473Y, 474A, 475T, 476I, 477I, 478E, 479T, 480L, 481K, 482K, 483R, 484E, 485Y, 486I, 487V, 488M, 489E, 493F, 494I, 495P, 496T, 497E, 498I, 499G, 500Y, 501E, 502V, 503K, 504A, 505Q, 506L, 507E, 513I, 514M, 515N, 516V, 517K, 518F, 519T, 520A, 521E, 522L, 523E, 524N, 525E, 526L, 527D, 528G, 529V, 530E, 531L, 532G, 533T, 534E, 535D, 536W, 537I, 538S, 539L, 540L, 541H, 542R, 543F, 544Y, 545D, 546G, 547L, 548K, 549E
CDD
cd00186 (TOP1Ac)

540L

domain IV
449P, 450P, 451A, 452R, 453L, 454T, 455E, 456S, 457S, 458L, 459V, 460K, 461M, 462L, 463E, 464T, 465E, 466G, 467I, 468G, 469R, 470P, 471S, 472T, 473Y, 474A, 475T, 476I, 477I, 478E, 479T, 480L, 481K, 482K, 483R, 484E, 485Y, 486I, 487V, 488M, 489E, 493F, 494I, 495P, 496T, 497E, 498I, 499G, 500Y, 501E, 502V, 503K, 504A, 505Q, 506L, 507E, 513I, 514M, 515N, 516V, 517K, 518F, 519T, 520A, 521E, 522L, 523E, 524N, 525E, 526L, 527D, 528G, 529V, 530E, 531L, 532G, 533T, 534E, 535D, 536W, 537I, 538S, 539L, 540L, 541H, 542R, 543F, 544Y, 545D, 546G, 547L, 548K, 549E
CDD
cd00186 (TOP1Ac)

541H

domain IV
449P, 450P, 451A, 452R, 453L, 454T, 455E, 456S, 457S, 458L, 459V, 460K, 461M, 462L, 463E, 464T, 465E, 466G, 467I, 468G, 469R, 470P, 471S, 472T, 473Y, 474A, 475T, 476I, 477I, 478E, 479T, 480L, 481K, 482K, 483R, 484E, 485Y, 486I, 487V, 488M, 489E, 493F, 494I, 495P, 496T, 497E, 498I, 499G, 500Y, 501E, 502V, 503K, 504A, 505Q, 506L, 507E, 513I, 514M, 515N, 516V, 517K, 518F, 519T, 520A, 521E, 522L, 523E, 524N, 525E, 526L, 527D, 528G, 529V, 530E, 531L, 532G, 533T, 534E, 535D, 536W, 537I, 538S, 539L, 540L, 541H, 542R, 543F, 544Y, 545D, 546G, 547L, 548K, 549E
CDD
cd00186 (TOP1Ac)

542R

domain IV
449P, 450P, 451A, 452R, 453L, 454T, 455E, 456S, 457S, 458L, 459V, 460K, 461M, 462L, 463E, 464T, 465E, 466G, 467I, 468G, 469R, 470P, 471S, 472T, 473Y, 474A, 475T, 476I, 477I, 478E, 479T, 480L, 481K, 482K, 483R, 484E, 485Y, 486I, 487V, 488M, 489E, 493F, 494I, 495P, 496T, 497E, 498I, 499G, 500Y, 501E, 502V, 503K, 504A, 505Q, 506L, 507E, 513I, 514M, 515N, 516V, 517K, 518F, 519T, 520A, 521E, 522L, 523E, 524N, 525E, 526L, 527D, 528G, 529V, 530E, 531L, 532G, 533T, 534E, 535D, 536W, 537I, 538S, 539L, 540L, 541H, 542R, 543F, 544Y, 545D, 546G, 547L, 548K, 549E
CDD
cd00186 (TOP1Ac)

543F

domain IV
449P, 450P, 451A, 452R, 453L, 454T, 455E, 456S, 457S, 458L, 459V, 460K, 461M, 462L, 463E, 464T, 465E, 466G, 467I, 468G, 469R, 470P, 471S, 472T, 473Y, 474A, 475T, 476I, 477I, 478E, 479T, 480L, 481K, 482K, 483R, 484E, 485Y, 486I, 487V, 488M, 489E, 493F, 494I, 495P, 496T, 497E, 498I, 499G, 500Y, 501E, 502V, 503K, 504A, 505Q, 506L, 507E, 513I, 514M, 515N, 516V, 517K, 518F, 519T, 520A, 521E, 522L, 523E, 524N, 525E, 526L, 527D, 528G, 529V, 530E, 531L, 532G, 533T, 534E, 535D, 536W, 537I, 538S, 539L, 540L, 541H, 542R, 543F, 544Y, 545D, 546G, 547L, 548K, 549E
CDD
cd00186 (TOP1Ac)

544Y

domain IV
449P, 450P, 451A, 452R, 453L, 454T, 455E, 456S, 457S, 458L, 459V, 460K, 461M, 462L, 463E, 464T, 465E, 466G, 467I, 468G, 469R, 470P, 471S, 472T, 473Y, 474A, 475T, 476I, 477I, 478E, 479T, 480L, 481K, 482K, 483R, 484E, 485Y, 486I, 487V, 488M, 489E, 493F, 494I, 495P, 496T, 497E, 498I, 499G, 500Y, 501E, 502V, 503K, 504A, 505Q, 506L, 507E, 513I, 514M, 515N, 516V, 517K, 518F, 519T, 520A, 521E, 522L, 523E, 524N, 525E, 526L, 527D, 528G, 529V, 530E, 531L, 532G, 533T, 534E, 535D, 536W, 537I, 538S, 539L, 540L, 541H, 542R, 543F, 544Y, 545D, 546G, 547L, 548K, 549E
CDD
cd00186 (TOP1Ac)

545D

domain IV
449P, 450P, 451A, 452R, 453L, 454T, 455E, 456S, 457S, 458L, 459V, 460K, 461M, 462L, 463E, 464T, 465E, 466G, 467I, 468G, 469R, 470P, 471S, 472T, 473Y, 474A, 475T, 476I, 477I, 478E, 479T, 480L, 481K, 482K, 483R, 484E, 485Y, 486I, 487V, 488M, 489E, 493F, 494I, 495P, 496T, 497E, 498I, 499G, 500Y, 501E, 502V, 503K, 504A, 505Q, 506L, 507E, 513I, 514M, 515N, 516V, 517K, 518F, 519T, 520A, 521E, 522L, 523E, 524N, 525E, 526L, 527D, 528G, 529V, 530E, 531L, 532G, 533T, 534E, 535D, 536W, 537I, 538S, 539L, 540L, 541H, 542R, 543F, 544Y, 545D, 546G, 547L, 548K, 549E
CDD
cd00186 (TOP1Ac)

546G

domain IV
449P, 450P, 451A, 452R, 453L, 454T, 455E, 456S, 457S, 458L, 459V, 460K, 461M, 462L, 463E, 464T, 465E, 466G, 467I, 468G, 469R, 470P, 471S, 472T, 473Y, 474A, 475T, 476I, 477I, 478E, 479T, 480L, 481K, 482K, 483R, 484E, 485Y, 486I, 487V, 488M, 489E, 493F, 494I, 495P, 496T, 497E, 498I, 499G, 500Y, 501E, 502V, 503K, 504A, 505Q, 506L, 507E, 513I, 514M, 515N, 516V, 517K, 518F, 519T, 520A, 521E, 522L, 523E, 524N, 525E, 526L, 527D, 528G, 529V, 530E, 531L, 532G, 533T, 534E, 535D, 536W, 537I, 538S, 539L, 540L, 541H, 542R, 543F, 544Y, 545D, 546G, 547L, 548K, 549E
CDD
cd00186 (TOP1Ac)

547L

domain IV
449P, 450P, 451A, 452R, 453L, 454T, 455E, 456S, 457S, 458L, 459V, 460K, 461M, 462L, 463E, 464T, 465E, 466G, 467I, 468G, 469R, 470P, 471S, 472T, 473Y, 474A, 475T, 476I, 477I, 478E, 479T, 480L, 481K, 482K, 483R, 484E, 485Y, 486I, 487V, 488M, 489E, 493F, 494I, 495P, 496T, 497E, 498I, 499G, 500Y, 501E, 502V, 503K, 504A, 505Q, 506L, 507E, 513I, 514M, 515N, 516V, 517K, 518F, 519T, 520A, 521E, 522L, 523E, 524N, 525E, 526L, 527D, 528G, 529V, 530E, 531L, 532G, 533T, 534E, 535D, 536W, 537I, 538S, 539L, 540L, 541H, 542R, 543F, 544Y, 545D, 546G, 547L, 548K, 549E
CDD
cd00186 (TOP1Ac)

548K

domain IV
449P, 450P, 451A, 452R, 453L, 454T, 455E, 456S, 457S, 458L, 459V, 460K, 461M, 462L, 463E, 464T, 465E, 466G, 467I, 468G, 469R, 470P, 471S, 472T, 473Y, 474A, 475T, 476I, 477I, 478E, 479T, 480L, 481K, 482K, 483R, 484E, 485Y, 486I, 487V, 488M, 489E, 493F, 494I, 495P, 496T, 497E, 498I, 499G, 500Y, 501E, 502V, 503K, 504A, 505Q, 506L, 507E, 513I, 514M, 515N, 516V, 517K, 518F, 519T, 520A, 521E, 522L, 523E, 524N, 525E, 526L, 527D, 528G, 529V, 530E, 531L, 532G, 533T, 534E, 535D, 536W, 537I, 538S, 539L, 540L, 541H, 542R, 543F, 544Y, 545D, 546G, 547L, 548K, 549E
CDD
cd00186 (TOP1Ac)

549E

domain IV
449P, 450P, 451A, 452R, 453L, 454T, 455E, 456S, 457S, 458L, 459V, 460K, 461M, 462L, 463E, 464T, 465E, 466G, 467I, 468G, 469R, 470P, 471S, 472T, 473Y, 474A, 475T, 476I, 477I, 478E, 479T, 480L, 481K, 482K, 483R, 484E, 485Y, 486I, 487V, 488M, 489E, 493F, 494I, 495P, 496T, 497E, 498I, 499G, 500Y, 501E, 502V, 503K, 504A, 505Q, 506L, 507E, 513I, 514M, 515N, 516V, 517K, 518F, 519T, 520A, 521E, 522L, 523E, 524N, 525E, 526L, 527D, 528G, 529V, 530E, 531L, 532G, 533T, 534E, 535D, 536W, 537I, 538S, 539L, 540L, 541H, 542R, 543F, 544Y, 545D, 546G, 547L, 548K, 549E
CDD
cd00186 (TOP1Ac)

GO term prediction

Biological Process

GO:0006265 DNA topological change

Molecular Function

GO:0003677 DNA binding
GO:0003916 DNA topoisomerase activity
GO:0003917 DNA topoisomerase type I activity

Cellular Component

GO:0005694 chromosome

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Entry type

Status

Per-residue features

1_1_36S_FusoPortal_Gene_2067

Protein family membership

Homologous superfamilies

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component