1_1_36S_FusoPortal_Gene_307

Protein

1_1_36S_FusoPortal_Gene_307

Length

810 amino acids

Protein family membership

DNA gyrase, subunit A (IPR005743)

Homologous superfamilies

Homologous superfamily
26 - 482
DNA topoisomerase, type IIA-like domain superfamily (IPR013760)
Homologous superfamily
30 - 211
DNA topoisomerase, type IIA, subunit A/ C-terminal, alpha-beta (IPR013758)
232 - 327
Arginine repressor-like, C-terminal (IPR024946)
340 - 482
Type IIA DNA topoisomerase subunit A, alpha-helical domain superfamily (IPR013757)
491 - 809
DNA gyrase/topoisomerase IV, subunit A, C-terminal (IPR035516)

1 100 200 300 400 500 600 700 810

Domains and repeats

Domain
28 - 467
DNA topoisomerase, type IIA, subunit A/C-terminal (IPR002205)
Repeat
500 - 542
DNA gyrase/topoisomerase IV, subunit A, C-terminal repeat (IPR006691)
549 - 597
DNA gyrase/topoisomerase IV, subunit A, C-terminal repeat (IPR006691)
606 - 649
DNA gyrase/topoisomerase IV, subunit A, C-terminal repeat (IPR006691)
655 - 700
DNA gyrase/topoisomerase IV, subunit A, C-terminal repeat (IPR006691)
706 - 750
DNA gyrase/topoisomerase IV, subunit A, C-terminal repeat (IPR006691)
757 - 802
DNA gyrase/topoisomerase IV, subunit A, C-terminal repeat (IPR006691)

1 100 200 300 400 500 600 700 810

Detailed signature matches

IPR013760

DNA topoisomerase, type IIA-like domain superfamily
1. SSF56719 (Type II D...)
  
  26 - 482
  
  SUPERFAMILY
  SSF56719 (Type II DNA topoisomerase)
IPR013758

DNA topoisomerase, type IIA, subunit A/ C-terminal, alpha-beta
1. G3DSA:3.90.19...
  
  30 - 211
  
  GENE3D
  G3DSA:3.90.199.10 (G3DSA:3.90.199.10)
IPR024946

Arginine repressor-like, C-terminal
1. G3DSA:3.30.13...
  
  232 - 327
  
  GENE3D
  G3DSA:3.30.1360.40 (G3DSA:3.30.1360.40)
IPR013757

Type IIA DNA topoisomerase subunit A, alpha-helical domain superfamily
1. G3DSA:1.10.26...
  
  340 - 482
  
  GENE3D
  G3DSA:1.10.268.10 (G3DSA:1.10.268.10)
IPR035516

DNA gyrase/topoisomerase IV, subunit A, C-terminal
1. SSF101904 (GyrA/Par...)
  
  494 - 809
  
  SUPERFAMILY
  SSF101904 (GyrA/ParC C-terminal domain-like)
2. G3DSA:2.120.1...
  
  491 - 804
  
  GENE3D
  G3DSA:2.120.10.90 (G3DSA:2.120.10.90)
IPR005743

DNA gyrase, subunit A
1. MF_01897 (GyrA)
  
  1 - 804
  
  HAMAP
  MF_01897 (GyrA)
IPR002205

DNA topoisomerase, type IIA, subunit A/C-terminal
1. PF00521 (DNA_topoisoIV)
  
  28 - 467
  
  Pfam
  PF00521 (DNA_topoisoIV)
IPR006691

DNA gyrase/topoisomerase IV, subunit A, C-terminal repeat
1. PF03989 (DNA_gyraseA_C)
  
  606 - 649
  
  Pfam
  PF03989 (DNA_gyraseA_C)
  
  549 - 597
  
  Pfam
  PF03989 (DNA_gyraseA_C)
  
  757 - 802
  
  Pfam
  PF03989 (DNA_gyraseA_C)
  
  706 - 750
  
  Pfam
  PF03989 (DNA_gyraseA_C)
  
  500 - 542
  
  Pfam
  PF03989 (DNA_gyraseA_C)
  
  655 - 700
  
  Pfam
  PF03989 (DNA_gyraseA_C)

no IPR

Unintegrated signatures

Coil

432 - 452

COILS
Coil (Coil)
PTHR43493 (FAMILY N...)

2 - 809

PANTHER
PTHR43493 (FAMILY NOT NAMED)
PTHR43493:SF5 (DNA ...)

2 - 809

PANTHER
PTHR43493:SF5 (DNA GYRASE SUBUNIT A)
TIGR01063

5 - 803

TIGRFAMs
TIGR01063 (TIGR01063)
cd00187 (TOP4c)

26 - 470

CDD
cd00187 (TOP4c)

Residue annotation

CAP-like domain cd...

26V

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

27S

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

28R

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

29A

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

30L

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

31P

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

32D

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

33V

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

34R

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

35D

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

36G

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

37L

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

38K

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

39P

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

40V

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

41H

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

42R

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

43R

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

44I

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

45L

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

46F

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

47A

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

48M

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

49N

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

50E

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

51M

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

52G

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

53M

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

58P

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

59F

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

60K

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

61K

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

62S

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

63A

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

64R

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

65I

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

66V

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

67G

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

68E

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

69V

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

70L

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

71G

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

72K

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

73Y

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

74H

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

75P

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

76H

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

77G

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

78D

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

79T

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

80A

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

81V

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

82Y

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

83N

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

84T

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

85M

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

86V

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

87R

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

88M

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

89A

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

90Q

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

91E

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

92F

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

93N

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

94Y

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

95R

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

96Y

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

97M

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

98L

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

99V

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

100E

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

101G

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

102H

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

103G

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

104N

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

105F

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

106G

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

107S

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

109D

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

110G

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

111D

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

112S

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

113A

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

114A

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

115A

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

116M

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

117R

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

118Y

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

119T

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

120E

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

121A

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

122R

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

123M

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

124S

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

125K

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

126I

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

127T

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

129E

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

130L

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

131L

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

132E

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

133D

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

134I

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

135D

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

136K

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

137N

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

138T

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

139I

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

140D

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

141F

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

142R

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

143K

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

144N

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

145F

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

146D

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

147D

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

148S

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

149L

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

150D

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

151E

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

152P

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)

155L

CAP-like domain
26V, 27S, 28R, 29A, 30L, 31P, 32D, 33V, 34R, 35D, 36G, 37L, 38K, 39P, 40V, 41H, 42R, 43R, 44I, 45L, 46F, 47A, 48M, 49N, 50E, 51M, 52G, 53M, 58P, 59F, 60K, 61K, 62S, 63A, 64R, 65I, 66V, 67G, 68E, 69V, 70L, 71G, 72K, 73Y, 74H, 75P, 76H, 77G, 78D, 79T, 80A, 81V, 82Y, 83N, 84T, 85M, 86V, 87R, 88M, 89A, 90Q, 91E, 92F, 93N, 94Y, 95R, 96Y, 97M, 98L, 99V, 100E, 101G, 102H, 103G, 104N, 105F, 106G, 107S, 109D, 110G, 111D, 112S, 113A, 114A, 115A, 116M, 117R, 118Y, 119T, 120E, 121A, 122R, 123M, 124S, 125K, 126I, 127T, 129E, 130L, 131L, 132E, 133D, 134I, 135D, 136K, 137N, 138T, 139I, 140D, 141F, 142R, 143K, 144N, 145F, 146D, 147D, 148S, 149L, 150D, 151E, 152P, 155L
CDD
cd00187 (TOP4c)
Active site cd00187

118Y

Active site
118Y
CDD
cd00187 (TOP4c)
primary dimer inte...

383E

primary dimer interface
383E, 384N, 385I, 388I, 389I, 390E, 391M, 402K, 403E, 417K, 418S, 419I, 420L, 421D, 422M, 423R, 424L, 425Q, 426R, 427L, 428T, 429G, 430L, 431E, 432R, 433E
CDD
cd00187 (TOP4c)

384N

primary dimer interface
383E, 384N, 385I, 388I, 389I, 390E, 391M, 402K, 403E, 417K, 418S, 419I, 420L, 421D, 422M, 423R, 424L, 425Q, 426R, 427L, 428T, 429G, 430L, 431E, 432R, 433E
CDD
cd00187 (TOP4c)

385I

primary dimer interface
383E, 384N, 385I, 388I, 389I, 390E, 391M, 402K, 403E, 417K, 418S, 419I, 420L, 421D, 422M, 423R, 424L, 425Q, 426R, 427L, 428T, 429G, 430L, 431E, 432R, 433E
CDD
cd00187 (TOP4c)

388I

primary dimer interface
383E, 384N, 385I, 388I, 389I, 390E, 391M, 402K, 403E, 417K, 418S, 419I, 420L, 421D, 422M, 423R, 424L, 425Q, 426R, 427L, 428T, 429G, 430L, 431E, 432R, 433E
CDD
cd00187 (TOP4c)

389I

primary dimer interface
383E, 384N, 385I, 388I, 389I, 390E, 391M, 402K, 403E, 417K, 418S, 419I, 420L, 421D, 422M, 423R, 424L, 425Q, 426R, 427L, 428T, 429G, 430L, 431E, 432R, 433E
CDD
cd00187 (TOP4c)

390E

primary dimer interface
383E, 384N, 385I, 388I, 389I, 390E, 391M, 402K, 403E, 417K, 418S, 419I, 420L, 421D, 422M, 423R, 424L, 425Q, 426R, 427L, 428T, 429G, 430L, 431E, 432R, 433E
CDD
cd00187 (TOP4c)

391M

primary dimer interface
383E, 384N, 385I, 388I, 389I, 390E, 391M, 402K, 403E, 417K, 418S, 419I, 420L, 421D, 422M, 423R, 424L, 425Q, 426R, 427L, 428T, 429G, 430L, 431E, 432R, 433E
CDD
cd00187 (TOP4c)

402K

primary dimer interface
383E, 384N, 385I, 388I, 389I, 390E, 391M, 402K, 403E, 417K, 418S, 419I, 420L, 421D, 422M, 423R, 424L, 425Q, 426R, 427L, 428T, 429G, 430L, 431E, 432R, 433E
CDD
cd00187 (TOP4c)

403E

primary dimer interface
383E, 384N, 385I, 388I, 389I, 390E, 391M, 402K, 403E, 417K, 418S, 419I, 420L, 421D, 422M, 423R, 424L, 425Q, 426R, 427L, 428T, 429G, 430L, 431E, 432R, 433E
CDD
cd00187 (TOP4c)

417K

primary dimer interface
383E, 384N, 385I, 388I, 389I, 390E, 391M, 402K, 403E, 417K, 418S, 419I, 420L, 421D, 422M, 423R, 424L, 425Q, 426R, 427L, 428T, 429G, 430L, 431E, 432R, 433E
CDD
cd00187 (TOP4c)

418S

primary dimer interface
383E, 384N, 385I, 388I, 389I, 390E, 391M, 402K, 403E, 417K, 418S, 419I, 420L, 421D, 422M, 423R, 424L, 425Q, 426R, 427L, 428T, 429G, 430L, 431E, 432R, 433E
CDD
cd00187 (TOP4c)

419I

primary dimer interface
383E, 384N, 385I, 388I, 389I, 390E, 391M, 402K, 403E, 417K, 418S, 419I, 420L, 421D, 422M, 423R, 424L, 425Q, 426R, 427L, 428T, 429G, 430L, 431E, 432R, 433E
CDD
cd00187 (TOP4c)

420L

primary dimer interface
383E, 384N, 385I, 388I, 389I, 390E, 391M, 402K, 403E, 417K, 418S, 419I, 420L, 421D, 422M, 423R, 424L, 425Q, 426R, 427L, 428T, 429G, 430L, 431E, 432R, 433E
CDD
cd00187 (TOP4c)

421D

primary dimer interface
383E, 384N, 385I, 388I, 389I, 390E, 391M, 402K, 403E, 417K, 418S, 419I, 420L, 421D, 422M, 423R, 424L, 425Q, 426R, 427L, 428T, 429G, 430L, 431E, 432R, 433E
CDD
cd00187 (TOP4c)

422M

primary dimer interface
383E, 384N, 385I, 388I, 389I, 390E, 391M, 402K, 403E, 417K, 418S, 419I, 420L, 421D, 422M, 423R, 424L, 425Q, 426R, 427L, 428T, 429G, 430L, 431E, 432R, 433E
CDD
cd00187 (TOP4c)

423R

primary dimer interface
383E, 384N, 385I, 388I, 389I, 390E, 391M, 402K, 403E, 417K, 418S, 419I, 420L, 421D, 422M, 423R, 424L, 425Q, 426R, 427L, 428T, 429G, 430L, 431E, 432R, 433E
CDD
cd00187 (TOP4c)

424L

primary dimer interface
383E, 384N, 385I, 388I, 389I, 390E, 391M, 402K, 403E, 417K, 418S, 419I, 420L, 421D, 422M, 423R, 424L, 425Q, 426R, 427L, 428T, 429G, 430L, 431E, 432R, 433E
CDD
cd00187 (TOP4c)

425Q

primary dimer interface
383E, 384N, 385I, 388I, 389I, 390E, 391M, 402K, 403E, 417K, 418S, 419I, 420L, 421D, 422M, 423R, 424L, 425Q, 426R, 427L, 428T, 429G, 430L, 431E, 432R, 433E
CDD
cd00187 (TOP4c)

426R

primary dimer interface
383E, 384N, 385I, 388I, 389I, 390E, 391M, 402K, 403E, 417K, 418S, 419I, 420L, 421D, 422M, 423R, 424L, 425Q, 426R, 427L, 428T, 429G, 430L, 431E, 432R, 433E
CDD
cd00187 (TOP4c)

427L

primary dimer interface
383E, 384N, 385I, 388I, 389I, 390E, 391M, 402K, 403E, 417K, 418S, 419I, 420L, 421D, 422M, 423R, 424L, 425Q, 426R, 427L, 428T, 429G, 430L, 431E, 432R, 433E
CDD
cd00187 (TOP4c)

428T

primary dimer interface
383E, 384N, 385I, 388I, 389I, 390E, 391M, 402K, 403E, 417K, 418S, 419I, 420L, 421D, 422M, 423R, 424L, 425Q, 426R, 427L, 428T, 429G, 430L, 431E, 432R, 433E
CDD
cd00187 (TOP4c)

429G

primary dimer interface
383E, 384N, 385I, 388I, 389I, 390E, 391M, 402K, 403E, 417K, 418S, 419I, 420L, 421D, 422M, 423R, 424L, 425Q, 426R, 427L, 428T, 429G, 430L, 431E, 432R, 433E
CDD
cd00187 (TOP4c)

430L

primary dimer interface
383E, 384N, 385I, 388I, 389I, 390E, 391M, 402K, 403E, 417K, 418S, 419I, 420L, 421D, 422M, 423R, 424L, 425Q, 426R, 427L, 428T, 429G, 430L, 431E, 432R, 433E
CDD
cd00187 (TOP4c)

431E

primary dimer interface
383E, 384N, 385I, 388I, 389I, 390E, 391M, 402K, 403E, 417K, 418S, 419I, 420L, 421D, 422M, 423R, 424L, 425Q, 426R, 427L, 428T, 429G, 430L, 431E, 432R, 433E
CDD
cd00187 (TOP4c)

432R

primary dimer interface
383E, 384N, 385I, 388I, 389I, 390E, 391M, 402K, 403E, 417K, 418S, 419I, 420L, 421D, 422M, 423R, 424L, 425Q, 426R, 427L, 428T, 429G, 430L, 431E, 432R, 433E
CDD
cd00187 (TOP4c)

433E

primary dimer interface
383E, 384N, 385I, 388I, 389I, 390E, 391M, 402K, 403E, 417K, 418S, 419I, 420L, 421D, 422M, 423R, 424L, 425Q, 426R, 427L, 428T, 429G, 430L, 431E, 432R, 433E
CDD
cd00187 (TOP4c)

GO term prediction

Biological Process

GO:0006259 DNA metabolic process
GO:0006265 DNA topological change

Molecular Function

GO:0003677 DNA binding
GO:0003916 DNA topoisomerase activity
GO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity
GO:0005524 ATP binding

Cellular Component

GO:0005694 chromosome

Filter view on

Entry type

Status

Per-residue features

1_1_36S_FusoPortal_Gene_307

Protein family membership

Homologous superfamilies

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component