1_1_36S_FusoPortal_Gene_447

Protein

1_1_36S_FusoPortal_Gene_447

Length

455 amino acids

Protein family membership

Fumarate lyase family (IPR000362)
- Argininosuccinate lyase (IPR009049)

Homologous superfamilies

Homologous superfamily
2 - 106
Fumarase/histidase, N-terminal (IPR024083)
Homologous superfamily
7 - 453
L-Aspartase-like (IPR008948)

1 50 100 150 200 250 300 350 400 455

Domains and repeats

Domain
7 - 300
Fumarate lyase, N-terminal (IPR022761)
363 - 430
Argininosuccinate lyase, C-terminal (IPR029419)

1 50 100 150 200 250 300 350 400 455

Detailed signature matches

IPR024083

Fumarase/histidase, N-terminal
1. G3DSA:1.10.27...
  
  2 - 106
  
  GENE3D
  G3DSA:1.10.275.10 (G3DSA:1.10.275.10)
IPR008948

L-Aspartase-like
1. SSF48557 (L-asparta...)
  
  7 - 453
  
  SUPERFAMILY
  SSF48557 (L-aspartase-like)
IPR000362

Fumarate lyase family
1. PR00149 (FUMRATELYASE)
  
  275 - 291
  
  PRINTS
  PR00149 (FUMRATELYASE)
  
  231 - 258
  
  PRINTS
  PR00149 (FUMRATELYASE)
  
  147 - 165
  
  PRINTS
  PR00149 (FUMRATELYASE)
  
  102 - 120
  
  PRINTS
  PR00149 (FUMRATELYASE)
IPR009049

Argininosuccinate lyase
1. PTHR43814 (FAMILY N...)
  
  5 - 454
  
  PANTHER
  PTHR43814 (FAMILY NOT NAMED)
2. cd01359 (Argininosu...)
  
  22 - 455
  
  CDD
  cd01359 (Argininosuccinate_lyase)
3. TIGR00838
  
  5 - 454
  
  TIGRFAMs
  TIGR00838 (TIGR00838)
4. MF_00006 (Arg_succ_...)
  
  2 - 453
  
  HAMAP
  MF_00006 (Arg_succ_lyase)
IPR022761

Fumarate lyase, N-terminal
1. PF00206 (Lyase_1)
  
  7 - 300
  
  Pfam
  PF00206 (Lyase_1)
IPR029419

Argininosuccinate lyase, C-terminal
1. PF14698 (ASL_C2)
  
  363 - 430
  
  Pfam
  PF14698 (ASL_C2)
IPR020557

Fumarate lyase, conserved site
1. PS00163 (FUMARATE_L...)
  
  275 - 284
  
  PROSITE patterns
  PS00163 (FUMARATE_LYASES)

no IPR

Unintegrated signatures

Coil

52 - 72

COILS
Coil (Coil)
G3DSA:1.10.40.30

375 - 432

GENE3D
G3DSA:1.10.40.30 (G3DSA:1.10.40.30)
G3DSA:1.20.20...

107 - 374

GENE3D
G3DSA:1.20.200.10 (G3DSA:1.20.200.10)
PR00145 (ARGSUCLYASE)

193 - 209

PRINTS
PR00145 (ARGSUCLYASE)

101 - 123

PRINTS
PR00145 (ARGSUCLYASE)

275 - 291

PRINTS
PR00145 (ARGSUCLYASE)

142 - 162

PRINTS
PR00145 (ARGSUCLYASE)

231 - 255

PRINTS
PR00145 (ARGSUCLYASE)

310 - 329

PRINTS
PR00145 (ARGSUCLYASE)

Residue annotation

active sites cd01359

22S

active sites
22S, 26D, 82D, 84H, 107S, 108R, 109N, 112V, 154T, 155H, 231R, 274T, 276S, 284N, 286D, 289E, 316Y, 318K, 321Q, 323D, 324K
CDD
cd01359 (Argininosuccinate_lyase)

26D

active sites
22S, 26D, 82D, 84H, 107S, 108R, 109N, 112V, 154T, 155H, 231R, 274T, 276S, 284N, 286D, 289E, 316Y, 318K, 321Q, 323D, 324K
CDD
cd01359 (Argininosuccinate_lyase)

82D

active sites
22S, 26D, 82D, 84H, 107S, 108R, 109N, 112V, 154T, 155H, 231R, 274T, 276S, 284N, 286D, 289E, 316Y, 318K, 321Q, 323D, 324K
CDD
cd01359 (Argininosuccinate_lyase)

84H

active sites
22S, 26D, 82D, 84H, 107S, 108R, 109N, 112V, 154T, 155H, 231R, 274T, 276S, 284N, 286D, 289E, 316Y, 318K, 321Q, 323D, 324K
CDD
cd01359 (Argininosuccinate_lyase)

107S

active sites
22S, 26D, 82D, 84H, 107S, 108R, 109N, 112V, 154T, 155H, 231R, 274T, 276S, 284N, 286D, 289E, 316Y, 318K, 321Q, 323D, 324K
CDD
cd01359 (Argininosuccinate_lyase)

108R

active sites
22S, 26D, 82D, 84H, 107S, 108R, 109N, 112V, 154T, 155H, 231R, 274T, 276S, 284N, 286D, 289E, 316Y, 318K, 321Q, 323D, 324K
CDD
cd01359 (Argininosuccinate_lyase)

109N

active sites
22S, 26D, 82D, 84H, 107S, 108R, 109N, 112V, 154T, 155H, 231R, 274T, 276S, 284N, 286D, 289E, 316Y, 318K, 321Q, 323D, 324K
CDD
cd01359 (Argininosuccinate_lyase)

112V

active sites
22S, 26D, 82D, 84H, 107S, 108R, 109N, 112V, 154T, 155H, 231R, 274T, 276S, 284N, 286D, 289E, 316Y, 318K, 321Q, 323D, 324K
CDD
cd01359 (Argininosuccinate_lyase)

154T

active sites
22S, 26D, 82D, 84H, 107S, 108R, 109N, 112V, 154T, 155H, 231R, 274T, 276S, 284N, 286D, 289E, 316Y, 318K, 321Q, 323D, 324K
CDD
cd01359 (Argininosuccinate_lyase)

155H

active sites
22S, 26D, 82D, 84H, 107S, 108R, 109N, 112V, 154T, 155H, 231R, 274T, 276S, 284N, 286D, 289E, 316Y, 318K, 321Q, 323D, 324K
CDD
cd01359 (Argininosuccinate_lyase)

231R

active sites
22S, 26D, 82D, 84H, 107S, 108R, 109N, 112V, 154T, 155H, 231R, 274T, 276S, 284N, 286D, 289E, 316Y, 318K, 321Q, 323D, 324K
CDD
cd01359 (Argininosuccinate_lyase)

274T

active sites
22S, 26D, 82D, 84H, 107S, 108R, 109N, 112V, 154T, 155H, 231R, 274T, 276S, 284N, 286D, 289E, 316Y, 318K, 321Q, 323D, 324K
CDD
cd01359 (Argininosuccinate_lyase)

276S

active sites
22S, 26D, 82D, 84H, 107S, 108R, 109N, 112V, 154T, 155H, 231R, 274T, 276S, 284N, 286D, 289E, 316Y, 318K, 321Q, 323D, 324K
CDD
cd01359 (Argininosuccinate_lyase)

284N

active sites
22S, 26D, 82D, 84H, 107S, 108R, 109N, 112V, 154T, 155H, 231R, 274T, 276S, 284N, 286D, 289E, 316Y, 318K, 321Q, 323D, 324K
CDD
cd01359 (Argininosuccinate_lyase)

286D

active sites
22S, 26D, 82D, 84H, 107S, 108R, 109N, 112V, 154T, 155H, 231R, 274T, 276S, 284N, 286D, 289E, 316Y, 318K, 321Q, 323D, 324K
CDD
cd01359 (Argininosuccinate_lyase)

289E

active sites
22S, 26D, 82D, 84H, 107S, 108R, 109N, 112V, 154T, 155H, 231R, 274T, 276S, 284N, 286D, 289E, 316Y, 318K, 321Q, 323D, 324K
CDD
cd01359 (Argininosuccinate_lyase)

316Y

active sites
22S, 26D, 82D, 84H, 107S, 108R, 109N, 112V, 154T, 155H, 231R, 274T, 276S, 284N, 286D, 289E, 316Y, 318K, 321Q, 323D, 324K
CDD
cd01359 (Argininosuccinate_lyase)

318K

active sites
22S, 26D, 82D, 84H, 107S, 108R, 109N, 112V, 154T, 155H, 231R, 274T, 276S, 284N, 286D, 289E, 316Y, 318K, 321Q, 323D, 324K
CDD
cd01359 (Argininosuccinate_lyase)

321Q

active sites
22S, 26D, 82D, 84H, 107S, 108R, 109N, 112V, 154T, 155H, 231R, 274T, 276S, 284N, 286D, 289E, 316Y, 318K, 321Q, 323D, 324K
CDD
cd01359 (Argininosuccinate_lyase)

323D

active sites
22S, 26D, 82D, 84H, 107S, 108R, 109N, 112V, 154T, 155H, 231R, 274T, 276S, 284N, 286D, 289E, 316Y, 318K, 321Q, 323D, 324K
CDD
cd01359 (Argininosuccinate_lyase)

324K

active sites
22S, 26D, 82D, 84H, 107S, 108R, 109N, 112V, 154T, 155H, 231R, 274T, 276S, 284N, 286D, 289E, 316Y, 318K, 321Q, 323D, 324K
CDD
cd01359 (Argininosuccinate_lyase)
tetramer interface...

97D

tetramer interface
97D, 100K, 103H, 104T, 153F, 154T, 155H, 156L, 157Q, 158K, 159A, 160Q, 166H, 170A, 171Y, 177R, 180Q, 181K, 184N, 188L, 199L, 200T, 201G, 202T, 203T, 205P, 208R, 222N, 223N, 224S, 225L, 226D, 229S, 230D, 232D, 236D, 239H, 243L, 246M, 247H, 249S, 250R, 253E, 254E, 259S, 260S, 263Y, 271D, 277S, 278I, 279M, 280P, 282K, 283K, 284N, 286D, 289E, 290L, 292R, 293G, 294K, 295T, 296G, 297R, 299F, 300G, 301H, 304A, 306F, 307T, 308T, 316Y, 317N, 318K, 319D, 322E, 325E, 336A, 339S, 366A, 371D, 380F, 381R, 384Y, 387V, 433R, 435T, 436F, 437G, 438S, 439P, 447H
CDD
cd01359 (Argininosuccinate_lyase)

100K

tetramer interface
97D, 100K, 103H, 104T, 153F, 154T, 155H, 156L, 157Q, 158K, 159A, 160Q, 166H, 170A, 171Y, 177R, 180Q, 181K, 184N, 188L, 199L, 200T, 201G, 202T, 203T, 205P, 208R, 222N, 223N, 224S, 225L, 226D, 229S, 230D, 232D, 236D, 239H, 243L, 246M, 247H, 249S, 250R, 253E, 254E, 259S, 260S, 263Y, 271D, 277S, 278I, 279M, 280P, 282K, 283K, 284N, 286D, 289E, 290L, 292R, 293G, 294K, 295T, 296G, 297R, 299F, 300G, 301H, 304A, 306F, 307T, 308T, 316Y, 317N, 318K, 319D, 322E, 325E, 336A, 339S, 366A, 371D, 380F, 381R, 384Y, 387V, 433R, 435T, 436F, 437G, 438S, 439P, 447H
CDD
cd01359 (Argininosuccinate_lyase)

103H

tetramer interface
97D, 100K, 103H, 104T, 153F, 154T, 155H, 156L, 157Q, 158K, 159A, 160Q, 166H, 170A, 171Y, 177R, 180Q, 181K, 184N, 188L, 199L, 200T, 201G, 202T, 203T, 205P, 208R, 222N, 223N, 224S, 225L, 226D, 229S, 230D, 232D, 236D, 239H, 243L, 246M, 247H, 249S, 250R, 253E, 254E, 259S, 260S, 263Y, 271D, 277S, 278I, 279M, 280P, 282K, 283K, 284N, 286D, 289E, 290L, 292R, 293G, 294K, 295T, 296G, 297R, 299F, 300G, 301H, 304A, 306F, 307T, 308T, 316Y, 317N, 318K, 319D, 322E, 325E, 336A, 339S, 366A, 371D, 380F, 381R, 384Y, 387V, 433R, 435T, 436F, 437G, 438S, 439P, 447H
CDD
cd01359 (Argininosuccinate_lyase)

104T

tetramer interface
97D, 100K, 103H, 104T, 153F, 154T, 155H, 156L, 157Q, 158K, 159A, 160Q, 166H, 170A, 171Y, 177R, 180Q, 181K, 184N, 188L, 199L, 200T, 201G, 202T, 203T, 205P, 208R, 222N, 223N, 224S, 225L, 226D, 229S, 230D, 232D, 236D, 239H, 243L, 246M, 247H, 249S, 250R, 253E, 254E, 259S, 260S, 263Y, 271D, 277S, 278I, 279M, 280P, 282K, 283K, 284N, 286D, 289E, 290L, 292R, 293G, 294K, 295T, 296G, 297R, 299F, 300G, 301H, 304A, 306F, 307T, 308T, 316Y, 317N, 318K, 319D, 322E, 325E, 336A, 339S, 366A, 371D, 380F, 381R, 384Y, 387V, 433R, 435T, 436F, 437G, 438S, 439P, 447H
CDD
cd01359 (Argininosuccinate_lyase)

153F

tetramer interface
97D, 100K, 103H, 104T, 153F, 154T, 155H, 156L, 157Q, 158K, 159A, 160Q, 166H, 170A, 171Y, 177R, 180Q, 181K, 184N, 188L, 199L, 200T, 201G, 202T, 203T, 205P, 208R, 222N, 223N, 224S, 225L, 226D, 229S, 230D, 232D, 236D, 239H, 243L, 246M, 247H, 249S, 250R, 253E, 254E, 259S, 260S, 263Y, 271D, 277S, 278I, 279M, 280P, 282K, 283K, 284N, 286D, 289E, 290L, 292R, 293G, 294K, 295T, 296G, 297R, 299F, 300G, 301H, 304A, 306F, 307T, 308T, 316Y, 317N, 318K, 319D, 322E, 325E, 336A, 339S, 366A, 371D, 380F, 381R, 384Y, 387V, 433R, 435T, 436F, 437G, 438S, 439P, 447H
CDD
cd01359 (Argininosuccinate_lyase)

154T

tetramer interface
97D, 100K, 103H, 104T, 153F, 154T, 155H, 156L, 157Q, 158K, 159A, 160Q, 166H, 170A, 171Y, 177R, 180Q, 181K, 184N, 188L, 199L, 200T, 201G, 202T, 203T, 205P, 208R, 222N, 223N, 224S, 225L, 226D, 229S, 230D, 232D, 236D, 239H, 243L, 246M, 247H, 249S, 250R, 253E, 254E, 259S, 260S, 263Y, 271D, 277S, 278I, 279M, 280P, 282K, 283K, 284N, 286D, 289E, 290L, 292R, 293G, 294K, 295T, 296G, 297R, 299F, 300G, 301H, 304A, 306F, 307T, 308T, 316Y, 317N, 318K, 319D, 322E, 325E, 336A, 339S, 366A, 371D, 380F, 381R, 384Y, 387V, 433R, 435T, 436F, 437G, 438S, 439P, 447H
CDD
cd01359 (Argininosuccinate_lyase)

155H

tetramer interface
97D, 100K, 103H, 104T, 153F, 154T, 155H, 156L, 157Q, 158K, 159A, 160Q, 166H, 170A, 171Y, 177R, 180Q, 181K, 184N, 188L, 199L, 200T, 201G, 202T, 203T, 205P, 208R, 222N, 223N, 224S, 225L, 226D, 229S, 230D, 232D, 236D, 239H, 243L, 246M, 247H, 249S, 250R, 253E, 254E, 259S, 260S, 263Y, 271D, 277S, 278I, 279M, 280P, 282K, 283K, 284N, 286D, 289E, 290L, 292R, 293G, 294K, 295T, 296G, 297R, 299F, 300G, 301H, 304A, 306F, 307T, 308T, 316Y, 317N, 318K, 319D, 322E, 325E, 336A, 339S, 366A, 371D, 380F, 381R, 384Y, 387V, 433R, 435T, 436F, 437G, 438S, 439P, 447H
CDD
cd01359 (Argininosuccinate_lyase)

156L

tetramer interface
97D, 100K, 103H, 104T, 153F, 154T, 155H, 156L, 157Q, 158K, 159A, 160Q, 166H, 170A, 171Y, 177R, 180Q, 181K, 184N, 188L, 199L, 200T, 201G, 202T, 203T, 205P, 208R, 222N, 223N, 224S, 225L, 226D, 229S, 230D, 232D, 236D, 239H, 243L, 246M, 247H, 249S, 250R, 253E, 254E, 259S, 260S, 263Y, 271D, 277S, 278I, 279M, 280P, 282K, 283K, 284N, 286D, 289E, 290L, 292R, 293G, 294K, 295T, 296G, 297R, 299F, 300G, 301H, 304A, 306F, 307T, 308T, 316Y, 317N, 318K, 319D, 322E, 325E, 336A, 339S, 366A, 371D, 380F, 381R, 384Y, 387V, 433R, 435T, 436F, 437G, 438S, 439P, 447H
CDD
cd01359 (Argininosuccinate_lyase)

157Q

tetramer interface
97D, 100K, 103H, 104T, 153F, 154T, 155H, 156L, 157Q, 158K, 159A, 160Q, 166H, 170A, 171Y, 177R, 180Q, 181K, 184N, 188L, 199L, 200T, 201G, 202T, 203T, 205P, 208R, 222N, 223N, 224S, 225L, 226D, 229S, 230D, 232D, 236D, 239H, 243L, 246M, 247H, 249S, 250R, 253E, 254E, 259S, 260S, 263Y, 271D, 277S, 278I, 279M, 280P, 282K, 283K, 284N, 286D, 289E, 290L, 292R, 293G, 294K, 295T, 296G, 297R, 299F, 300G, 301H, 304A, 306F, 307T, 308T, 316Y, 317N, 318K, 319D, 322E, 325E, 336A, 339S, 366A, 371D, 380F, 381R, 384Y, 387V, 433R, 435T, 436F, 437G, 438S, 439P, 447H
CDD
cd01359 (Argininosuccinate_lyase)

158K

tetramer interface
97D, 100K, 103H, 104T, 153F, 154T, 155H, 156L, 157Q, 158K, 159A, 160Q, 166H, 170A, 171Y, 177R, 180Q, 181K, 184N, 188L, 199L, 200T, 201G, 202T, 203T, 205P, 208R, 222N, 223N, 224S, 225L, 226D, 229S, 230D, 232D, 236D, 239H, 243L, 246M, 247H, 249S, 250R, 253E, 254E, 259S, 260S, 263Y, 271D, 277S, 278I, 279M, 280P, 282K, 283K, 284N, 286D, 289E, 290L, 292R, 293G, 294K, 295T, 296G, 297R, 299F, 300G, 301H, 304A, 306F, 307T, 308T, 316Y, 317N, 318K, 319D, 322E, 325E, 336A, 339S, 366A, 371D, 380F, 381R, 384Y, 387V, 433R, 435T, 436F, 437G, 438S, 439P, 447H
CDD
cd01359 (Argininosuccinate_lyase)

159A

tetramer interface
97D, 100K, 103H, 104T, 153F, 154T, 155H, 156L, 157Q, 158K, 159A, 160Q, 166H, 170A, 171Y, 177R, 180Q, 181K, 184N, 188L, 199L, 200T, 201G, 202T, 203T, 205P, 208R, 222N, 223N, 224S, 225L, 226D, 229S, 230D, 232D, 236D, 239H, 243L, 246M, 247H, 249S, 250R, 253E, 254E, 259S, 260S, 263Y, 271D, 277S, 278I, 279M, 280P, 282K, 283K, 284N, 286D, 289E, 290L, 292R, 293G, 294K, 295T, 296G, 297R, 299F, 300G, 301H, 304A, 306F, 307T, 308T, 316Y, 317N, 318K, 319D, 322E, 325E, 336A, 339S, 366A, 371D, 380F, 381R, 384Y, 387V, 433R, 435T, 436F, 437G, 438S, 439P, 447H
CDD
cd01359 (Argininosuccinate_lyase)

160Q

tetramer interface
97D, 100K, 103H, 104T, 153F, 154T, 155H, 156L, 157Q, 158K, 159A, 160Q, 166H, 170A, 171Y, 177R, 180Q, 181K, 184N, 188L, 199L, 200T, 201G, 202T, 203T, 205P, 208R, 222N, 223N, 224S, 225L, 226D, 229S, 230D, 232D, 236D, 239H, 243L, 246M, 247H, 249S, 250R, 253E, 254E, 259S, 260S, 263Y, 271D, 277S, 278I, 279M, 280P, 282K, 283K, 284N, 286D, 289E, 290L, 292R, 293G, 294K, 295T, 296G, 297R, 299F, 300G, 301H, 304A, 306F, 307T, 308T, 316Y, 317N, 318K, 319D, 322E, 325E, 336A, 339S, 366A, 371D, 380F, 381R, 384Y, 387V, 433R, 435T, 436F, 437G, 438S, 439P, 447H
CDD
cd01359 (Argininosuccinate_lyase)

166H

tetramer interface
97D, 100K, 103H, 104T, 153F, 154T, 155H, 156L, 157Q, 158K, 159A, 160Q, 166H, 170A, 171Y, 177R, 180Q, 181K, 184N, 188L, 199L, 200T, 201G, 202T, 203T, 205P, 208R, 222N, 223N, 224S, 225L, 226D, 229S, 230D, 232D, 236D, 239H, 243L, 246M, 247H, 249S, 250R, 253E, 254E, 259S, 260S, 263Y, 271D, 277S, 278I, 279M, 280P, 282K, 283K, 284N, 286D, 289E, 290L, 292R, 293G, 294K, 295T, 296G, 297R, 299F, 300G, 301H, 304A, 306F, 307T, 308T, 316Y, 317N, 318K, 319D, 322E, 325E, 336A, 339S, 366A, 371D, 380F, 381R, 384Y, 387V, 433R, 435T, 436F, 437G, 438S, 439P, 447H
CDD
cd01359 (Argininosuccinate_lyase)

170A

tetramer interface
97D, 100K, 103H, 104T, 153F, 154T, 155H, 156L, 157Q, 158K, 159A, 160Q, 166H, 170A, 171Y, 177R, 180Q, 181K, 184N, 188L, 199L, 200T, 201G, 202T, 203T, 205P, 208R, 222N, 223N, 224S, 225L, 226D, 229S, 230D, 232D, 236D, 239H, 243L, 246M, 247H, 249S, 250R, 253E, 254E, 259S, 260S, 263Y, 271D, 277S, 278I, 279M, 280P, 282K, 283K, 284N, 286D, 289E, 290L, 292R, 293G, 294K, 295T, 296G, 297R, 299F, 300G, 301H, 304A, 306F, 307T, 308T, 316Y, 317N, 318K, 319D, 322E, 325E, 336A, 339S, 366A, 371D, 380F, 381R, 384Y, 387V, 433R, 435T, 436F, 437G, 438S, 439P, 447H
CDD
cd01359 (Argininosuccinate_lyase)

171Y

tetramer interface
97D, 100K, 103H, 104T, 153F, 154T, 155H, 156L, 157Q, 158K, 159A, 160Q, 166H, 170A, 171Y, 177R, 180Q, 181K, 184N, 188L, 199L, 200T, 201G, 202T, 203T, 205P, 208R, 222N, 223N, 224S, 225L, 226D, 229S, 230D, 232D, 236D, 239H, 243L, 246M, 247H, 249S, 250R, 253E, 254E, 259S, 260S, 263Y, 271D, 277S, 278I, 279M, 280P, 282K, 283K, 284N, 286D, 289E, 290L, 292R, 293G, 294K, 295T, 296G, 297R, 299F, 300G, 301H, 304A, 306F, 307T, 308T, 316Y, 317N, 318K, 319D, 322E, 325E, 336A, 339S, 366A, 371D, 380F, 381R, 384Y, 387V, 433R, 435T, 436F, 437G, 438S, 439P, 447H
CDD
cd01359 (Argininosuccinate_lyase)

177R

tetramer interface
97D, 100K, 103H, 104T, 153F, 154T, 155H, 156L, 157Q, 158K, 159A, 160Q, 166H, 170A, 171Y, 177R, 180Q, 181K, 184N, 188L, 199L, 200T, 201G, 202T, 203T, 205P, 208R, 222N, 223N, 224S, 225L, 226D, 229S, 230D, 232D, 236D, 239H, 243L, 246M, 247H, 249S, 250R, 253E, 254E, 259S, 260S, 263Y, 271D, 277S, 278I, 279M, 280P, 282K, 283K, 284N, 286D, 289E, 290L, 292R, 293G, 294K, 295T, 296G, 297R, 299F, 300G, 301H, 304A, 306F, 307T, 308T, 316Y, 317N, 318K, 319D, 322E, 325E, 336A, 339S, 366A, 371D, 380F, 381R, 384Y, 387V, 433R, 435T, 436F, 437G, 438S, 439P, 447H
CDD
cd01359 (Argininosuccinate_lyase)

180Q

tetramer interface
97D, 100K, 103H, 104T, 153F, 154T, 155H, 156L, 157Q, 158K, 159A, 160Q, 166H, 170A, 171Y, 177R, 180Q, 181K, 184N, 188L, 199L, 200T, 201G, 202T, 203T, 205P, 208R, 222N, 223N, 224S, 225L, 226D, 229S, 230D, 232D, 236D, 239H, 243L, 246M, 247H, 249S, 250R, 253E, 254E, 259S, 260S, 263Y, 271D, 277S, 278I, 279M, 280P, 282K, 283K, 284N, 286D, 289E, 290L, 292R, 293G, 294K, 295T, 296G, 297R, 299F, 300G, 301H, 304A, 306F, 307T, 308T, 316Y, 317N, 318K, 319D, 322E, 325E, 336A, 339S, 366A, 371D, 380F, 381R, 384Y, 387V, 433R, 435T, 436F, 437G, 438S, 439P, 447H
CDD
cd01359 (Argininosuccinate_lyase)

181K

tetramer interface
97D, 100K, 103H, 104T, 153F, 154T, 155H, 156L, 157Q, 158K, 159A, 160Q, 166H, 170A, 171Y, 177R, 180Q, 181K, 184N, 188L, 199L, 200T, 201G, 202T, 203T, 205P, 208R, 222N, 223N, 224S, 225L, 226D, 229S, 230D, 232D, 236D, 239H, 243L, 246M, 247H, 249S, 250R, 253E, 254E, 259S, 260S, 263Y, 271D, 277S, 278I, 279M, 280P, 282K, 283K, 284N, 286D, 289E, 290L, 292R, 293G, 294K, 295T, 296G, 297R, 299F, 300G, 301H, 304A, 306F, 307T, 308T, 316Y, 317N, 318K, 319D, 322E, 325E, 336A, 339S, 366A, 371D, 380F, 381R, 384Y, 387V, 433R, 435T, 436F, 437G, 438S, 439P, 447H
CDD
cd01359 (Argininosuccinate_lyase)

184N

tetramer interface
97D, 100K, 103H, 104T, 153F, 154T, 155H, 156L, 157Q, 158K, 159A, 160Q, 166H, 170A, 171Y, 177R, 180Q, 181K, 184N, 188L, 199L, 200T, 201G, 202T, 203T, 205P, 208R, 222N, 223N, 224S, 225L, 226D, 229S, 230D, 232D, 236D, 239H, 243L, 246M, 247H, 249S, 250R, 253E, 254E, 259S, 260S, 263Y, 271D, 277S, 278I, 279M, 280P, 282K, 283K, 284N, 286D, 289E, 290L, 292R, 293G, 294K, 295T, 296G, 297R, 299F, 300G, 301H, 304A, 306F, 307T, 308T, 316Y, 317N, 318K, 319D, 322E, 325E, 336A, 339S, 366A, 371D, 380F, 381R, 384Y, 387V, 433R, 435T, 436F, 437G, 438S, 439P, 447H
CDD
cd01359 (Argininosuccinate_lyase)

188L

tetramer interface
97D, 100K, 103H, 104T, 153F, 154T, 155H, 156L, 157Q, 158K, 159A, 160Q, 166H, 170A, 171Y, 177R, 180Q, 181K, 184N, 188L, 199L, 200T, 201G, 202T, 203T, 205P, 208R, 222N, 223N, 224S, 225L, 226D, 229S, 230D, 232D, 236D, 239H, 243L, 246M, 247H, 249S, 250R, 253E, 254E, 259S, 260S, 263Y, 271D, 277S, 278I, 279M, 280P, 282K, 283K, 284N, 286D, 289E, 290L, 292R, 293G, 294K, 295T, 296G, 297R, 299F, 300G, 301H, 304A, 306F, 307T, 308T, 316Y, 317N, 318K, 319D, 322E, 325E, 336A, 339S, 366A, 371D, 380F, 381R, 384Y, 387V, 433R, 435T, 436F, 437G, 438S, 439P, 447H
CDD
cd01359 (Argininosuccinate_lyase)

199L

tetramer interface
97D, 100K, 103H, 104T, 153F, 154T, 155H, 156L, 157Q, 158K, 159A, 160Q, 166H, 170A, 171Y, 177R, 180Q, 181K, 184N, 188L, 199L, 200T, 201G, 202T, 203T, 205P, 208R, 222N, 223N, 224S, 225L, 226D, 229S, 230D, 232D, 236D, 239H, 243L, 246M, 247H, 249S, 250R, 253E, 254E, 259S, 260S, 263Y, 271D, 277S, 278I, 279M, 280P, 282K, 283K, 284N, 286D, 289E, 290L, 292R, 293G, 294K, 295T, 296G, 297R, 299F, 300G, 301H, 304A, 306F, 307T, 308T, 316Y, 317N, 318K, 319D, 322E, 325E, 336A, 339S, 366A, 371D, 380F, 381R, 384Y, 387V, 433R, 435T, 436F, 437G, 438S, 439P, 447H
CDD
cd01359 (Argininosuccinate_lyase)

200T

tetramer interface
97D, 100K, 103H, 104T, 153F, 154T, 155H, 156L, 157Q, 158K, 159A, 160Q, 166H, 170A, 171Y, 177R, 180Q, 181K, 184N, 188L, 199L, 200T, 201G, 202T, 203T, 205P, 208R, 222N, 223N, 224S, 225L, 226D, 229S, 230D, 232D, 236D, 239H, 243L, 246M, 247H, 249S, 250R, 253E, 254E, 259S, 260S, 263Y, 271D, 277S, 278I, 279M, 280P, 282K, 283K, 284N, 286D, 289E, 290L, 292R, 293G, 294K, 295T, 296G, 297R, 299F, 300G, 301H, 304A, 306F, 307T, 308T, 316Y, 317N, 318K, 319D, 322E, 325E, 336A, 339S, 366A, 371D, 380F, 381R, 384Y, 387V, 433R, 435T, 436F, 437G, 438S, 439P, 447H
CDD
cd01359 (Argininosuccinate_lyase)

201G

tetramer interface
97D, 100K, 103H, 104T, 153F, 154T, 155H, 156L, 157Q, 158K, 159A, 160Q, 166H, 170A, 171Y, 177R, 180Q, 181K, 184N, 188L, 199L, 200T, 201G, 202T, 203T, 205P, 208R, 222N, 223N, 224S, 225L, 226D, 229S, 230D, 232D, 236D, 239H, 243L, 246M, 247H, 249S, 250R, 253E, 254E, 259S, 260S, 263Y, 271D, 277S, 278I, 279M, 280P, 282K, 283K, 284N, 286D, 289E, 290L, 292R, 293G, 294K, 295T, 296G, 297R, 299F, 300G, 301H, 304A, 306F, 307T, 308T, 316Y, 317N, 318K, 319D, 322E, 325E, 336A, 339S, 366A, 371D, 380F, 381R, 384Y, 387V, 433R, 435T, 436F, 437G, 438S, 439P, 447H
CDD
cd01359 (Argininosuccinate_lyase)

202T

tetramer interface
97D, 100K, 103H, 104T, 153F, 154T, 155H, 156L, 157Q, 158K, 159A, 160Q, 166H, 170A, 171Y, 177R, 180Q, 181K, 184N, 188L, 199L, 200T, 201G, 202T, 203T, 205P, 208R, 222N, 223N, 224S, 225L, 226D, 229S, 230D, 232D, 236D, 239H, 243L, 246M, 247H, 249S, 250R, 253E, 254E, 259S, 260S, 263Y, 271D, 277S, 278I, 279M, 280P, 282K, 283K, 284N, 286D, 289E, 290L, 292R, 293G, 294K, 295T, 296G, 297R, 299F, 300G, 301H, 304A, 306F, 307T, 308T, 316Y, 317N, 318K, 319D, 322E, 325E, 336A, 339S, 366A, 371D, 380F, 381R, 384Y, 387V, 433R, 435T, 436F, 437G, 438S, 439P, 447H
CDD
cd01359 (Argininosuccinate_lyase)

203T

tetramer interface
97D, 100K, 103H, 104T, 153F, 154T, 155H, 156L, 157Q, 158K, 159A, 160Q, 166H, 170A, 171Y, 177R, 180Q, 181K, 184N, 188L, 199L, 200T, 201G, 202T, 203T, 205P, 208R, 222N, 223N, 224S, 225L, 226D, 229S, 230D, 232D, 236D, 239H, 243L, 246M, 247H, 249S, 250R, 253E, 254E, 259S, 260S, 263Y, 271D, 277S, 278I, 279M, 280P, 282K, 283K, 284N, 286D, 289E, 290L, 292R, 293G, 294K, 295T, 296G, 297R, 299F, 300G, 301H, 304A, 306F, 307T, 308T, 316Y, 317N, 318K, 319D, 322E, 325E, 336A, 339S, 366A, 371D, 380F, 381R, 384Y, 387V, 433R, 435T, 436F, 437G, 438S, 439P, 447H
CDD
cd01359 (Argininosuccinate_lyase)

205P

tetramer interface
97D, 100K, 103H, 104T, 153F, 154T, 155H, 156L, 157Q, 158K, 159A, 160Q, 166H, 170A, 171Y, 177R, 180Q, 181K, 184N, 188L, 199L, 200T, 201G, 202T, 203T, 205P, 208R, 222N, 223N, 224S, 225L, 226D, 229S, 230D, 232D, 236D, 239H, 243L, 246M, 247H, 249S, 250R, 253E, 254E, 259S, 260S, 263Y, 271D, 277S, 278I, 279M, 280P, 282K, 283K, 284N, 286D, 289E, 290L, 292R, 293G, 294K, 295T, 296G, 297R, 299F, 300G, 301H, 304A, 306F, 307T, 308T, 316Y, 317N, 318K, 319D, 322E, 325E, 336A, 339S, 366A, 371D, 380F, 381R, 384Y, 387V, 433R, 435T, 436F, 437G, 438S, 439P, 447H
CDD
cd01359 (Argininosuccinate_lyase)

208R

tetramer interface
97D, 100K, 103H, 104T, 153F, 154T, 155H, 156L, 157Q, 158K, 159A, 160Q, 166H, 170A, 171Y, 177R, 180Q, 181K, 184N, 188L, 199L, 200T, 201G, 202T, 203T, 205P, 208R, 222N, 223N, 224S, 225L, 226D, 229S, 230D, 232D, 236D, 239H, 243L, 246M, 247H, 249S, 250R, 253E, 254E, 259S, 260S, 263Y, 271D, 277S, 278I, 279M, 280P, 282K, 283K, 284N, 286D, 289E, 290L, 292R, 293G, 294K, 295T, 296G, 297R, 299F, 300G, 301H, 304A, 306F, 307T, 308T, 316Y, 317N, 318K, 319D, 322E, 325E, 336A, 339S, 366A, 371D, 380F, 381R, 384Y, 387V, 433R, 435T, 436F, 437G, 438S, 439P, 447H
CDD
cd01359 (Argininosuccinate_lyase)

222N

tetramer interface
97D, 100K, 103H, 104T, 153F, 154T, 155H, 156L, 157Q, 158K, 159A, 160Q, 166H, 170A, 171Y, 177R, 180Q, 181K, 184N, 188L, 199L, 200T, 201G, 202T, 203T, 205P, 208R, 222N, 223N, 224S, 225L, 226D, 229S, 230D, 232D, 236D, 239H, 243L, 246M, 247H, 249S, 250R, 253E, 254E, 259S, 260S, 263Y, 271D, 277S, 278I, 279M, 280P, 282K, 283K, 284N, 286D, 289E, 290L, 292R, 293G, 294K, 295T, 296G, 297R, 299F, 300G, 301H, 304A, 306F, 307T, 308T, 316Y, 317N, 318K, 319D, 322E, 325E, 336A, 339S, 366A, 371D, 380F, 381R, 384Y, 387V, 433R, 435T, 436F, 437G, 438S, 439P, 447H
CDD
cd01359 (Argininosuccinate_lyase)

223N

tetramer interface
97D, 100K, 103H, 104T, 153F, 154T, 155H, 156L, 157Q, 158K, 159A, 160Q, 166H, 170A, 171Y, 177R, 180Q, 181K, 184N, 188L, 199L, 200T, 201G, 202T, 203T, 205P, 208R, 222N, 223N, 224S, 225L, 226D, 229S, 230D, 232D, 236D, 239H, 243L, 246M, 247H, 249S, 250R, 253E, 254E, 259S, 260S, 263Y, 271D, 277S, 278I, 279M, 280P, 282K, 283K, 284N, 286D, 289E, 290L, 292R, 293G, 294K, 295T, 296G, 297R, 299F, 300G, 301H, 304A, 306F, 307T, 308T, 316Y, 317N, 318K, 319D, 322E, 325E, 336A, 339S, 366A, 371D, 380F, 381R, 384Y, 387V, 433R, 435T, 436F, 437G, 438S, 439P, 447H
CDD
cd01359 (Argininosuccinate_lyase)

224S

tetramer interface
97D, 100K, 103H, 104T, 153F, 154T, 155H, 156L, 157Q, 158K, 159A, 160Q, 166H, 170A, 171Y, 177R, 180Q, 181K, 184N, 188L, 199L, 200T, 201G, 202T, 203T, 205P, 208R, 222N, 223N, 224S, 225L, 226D, 229S, 230D, 232D, 236D, 239H, 243L, 246M, 247H, 249S, 250R, 253E, 254E, 259S, 260S, 263Y, 271D, 277S, 278I, 279M, 280P, 282K, 283K, 284N, 286D, 289E, 290L, 292R, 293G, 294K, 295T, 296G, 297R, 299F, 300G, 301H, 304A, 306F, 307T, 308T, 316Y, 317N, 318K, 319D, 322E, 325E, 336A, 339S, 366A, 371D, 380F, 381R, 384Y, 387V, 433R, 435T, 436F, 437G, 438S, 439P, 447H
CDD
cd01359 (Argininosuccinate_lyase)

225L

tetramer interface
97D, 100K, 103H, 104T, 153F, 154T, 155H, 156L, 157Q, 158K, 159A, 160Q, 166H, 170A, 171Y, 177R, 180Q, 181K, 184N, 188L, 199L, 200T, 201G, 202T, 203T, 205P, 208R, 222N, 223N, 224S, 225L, 226D, 229S, 230D, 232D, 236D, 239H, 243L, 246M, 247H, 249S, 250R, 253E, 254E, 259S, 260S, 263Y, 271D, 277S, 278I, 279M, 280P, 282K, 283K, 284N, 286D, 289E, 290L, 292R, 293G, 294K, 295T, 296G, 297R, 299F, 300G, 301H, 304A, 306F, 307T, 308T, 316Y, 317N, 318K, 319D, 322E, 325E, 336A, 339S, 366A, 371D, 380F, 381R, 384Y, 387V, 433R, 435T, 436F, 437G, 438S, 439P, 447H
CDD
cd01359 (Argininosuccinate_lyase)

226D

tetramer interface
97D, 100K, 103H, 104T, 153F, 154T, 155H, 156L, 157Q, 158K, 159A, 160Q, 166H, 170A, 171Y, 177R, 180Q, 181K, 184N, 188L, 199L, 200T, 201G, 202T, 203T, 205P, 208R, 222N, 223N, 224S, 225L, 226D, 229S, 230D, 232D, 236D, 239H, 243L, 246M, 247H, 249S, 250R, 253E, 254E, 259S, 260S, 263Y, 271D, 277S, 278I, 279M, 280P, 282K, 283K, 284N, 286D, 289E, 290L, 292R, 293G, 294K, 295T, 296G, 297R, 299F, 300G, 301H, 304A, 306F, 307T, 308T, 316Y, 317N, 318K, 319D, 322E, 325E, 336A, 339S, 366A, 371D, 380F, 381R, 384Y, 387V, 433R, 435T, 436F, 437G, 438S, 439P, 447H
CDD
cd01359 (Argininosuccinate_lyase)

229S

tetramer interface
97D, 100K, 103H, 104T, 153F, 154T, 155H, 156L, 157Q, 158K, 159A, 160Q, 166H, 170A, 171Y, 177R, 180Q, 181K, 184N, 188L, 199L, 200T, 201G, 202T, 203T, 205P, 208R, 222N, 223N, 224S, 225L, 226D, 229S, 230D, 232D, 236D, 239H, 243L, 246M, 247H, 249S, 250R, 253E, 254E, 259S, 260S, 263Y, 271D, 277S, 278I, 279M, 280P, 282K, 283K, 284N, 286D, 289E, 290L, 292R, 293G, 294K, 295T, 296G, 297R, 299F, 300G, 301H, 304A, 306F, 307T, 308T, 316Y, 317N, 318K, 319D, 322E, 325E, 336A, 339S, 366A, 371D, 380F, 381R, 384Y, 387V, 433R, 435T, 436F, 437G, 438S, 439P, 447H
CDD
cd01359 (Argininosuccinate_lyase)

230D

tetramer interface
97D, 100K, 103H, 104T, 153F, 154T, 155H, 156L, 157Q, 158K, 159A, 160Q, 166H, 170A, 171Y, 177R, 180Q, 181K, 184N, 188L, 199L, 200T, 201G, 202T, 203T, 205P, 208R, 222N, 223N, 224S, 225L, 226D, 229S, 230D, 232D, 236D, 239H, 243L, 246M, 247H, 249S, 250R, 253E, 254E, 259S, 260S, 263Y, 271D, 277S, 278I, 279M, 280P, 282K, 283K, 284N, 286D, 289E, 290L, 292R, 293G, 294K, 295T, 296G, 297R, 299F, 300G, 301H, 304A, 306F, 307T, 308T, 316Y, 317N, 318K, 319D, 322E, 325E, 336A, 339S, 366A, 371D, 380F, 381R, 384Y, 387V, 433R, 435T, 436F, 437G, 438S, 439P, 447H
CDD
cd01359 (Argininosuccinate_lyase)

232D

tetramer interface
97D, 100K, 103H, 104T, 153F, 154T, 155H, 156L, 157Q, 158K, 159A, 160Q, 166H, 170A, 171Y, 177R, 180Q, 181K, 184N, 188L, 199L, 200T, 201G, 202T, 203T, 205P, 208R, 222N, 223N, 224S, 225L, 226D, 229S, 230D, 232D, 236D, 239H, 243L, 246M, 247H, 249S, 250R, 253E, 254E, 259S, 260S, 263Y, 271D, 277S, 278I, 279M, 280P, 282K, 283K, 284N, 286D, 289E, 290L, 292R, 293G, 294K, 295T, 296G, 297R, 299F, 300G, 301H, 304A, 306F, 307T, 308T, 316Y, 317N, 318K, 319D, 322E, 325E, 336A, 339S, 366A, 371D, 380F, 381R, 384Y, 387V, 433R, 435T, 436F, 437G, 438S, 439P, 447H
CDD
cd01359 (Argininosuccinate_lyase)

236D

tetramer interface
97D, 100K, 103H, 104T, 153F, 154T, 155H, 156L, 157Q, 158K, 159A, 160Q, 166H, 170A, 171Y, 177R, 180Q, 181K, 184N, 188L, 199L, 200T, 201G, 202T, 203T, 205P, 208R, 222N, 223N, 224S, 225L, 226D, 229S, 230D, 232D, 236D, 239H, 243L, 246M, 247H, 249S, 250R, 253E, 254E, 259S, 260S, 263Y, 271D, 277S, 278I, 279M, 280P, 282K, 283K, 284N, 286D, 289E, 290L, 292R, 293G, 294K, 295T, 296G, 297R, 299F, 300G, 301H, 304A, 306F, 307T, 308T, 316Y, 317N, 318K, 319D, 322E, 325E, 336A, 339S, 366A, 371D, 380F, 381R, 384Y, 387V, 433R, 435T, 436F, 437G, 438S, 439P, 447H
CDD
cd01359 (Argininosuccinate_lyase)

239H

tetramer interface
97D, 100K, 103H, 104T, 153F, 154T, 155H, 156L, 157Q, 158K, 159A, 160Q, 166H, 170A, 171Y, 177R, 180Q, 181K, 184N, 188L, 199L, 200T, 201G, 202T, 203T, 205P, 208R, 222N, 223N, 224S, 225L, 226D, 229S, 230D, 232D, 236D, 239H, 243L, 246M, 247H, 249S, 250R, 253E, 254E, 259S, 260S, 263Y, 271D, 277S, 278I, 279M, 280P, 282K, 283K, 284N, 286D, 289E, 290L, 292R, 293G, 294K, 295T, 296G, 297R, 299F, 300G, 301H, 304A, 306F, 307T, 308T, 316Y, 317N, 318K, 319D, 322E, 325E, 336A, 339S, 366A, 371D, 380F, 381R, 384Y, 387V, 433R, 435T, 436F, 437G, 438S, 439P, 447H
CDD
cd01359 (Argininosuccinate_lyase)

243L

tetramer interface
97D, 100K, 103H, 104T, 153F, 154T, 155H, 156L, 157Q, 158K, 159A, 160Q, 166H, 170A, 171Y, 177R, 180Q, 181K, 184N, 188L, 199L, 200T, 201G, 202T, 203T, 205P, 208R, 222N, 223N, 224S, 225L, 226D, 229S, 230D, 232D, 236D, 239H, 243L, 246M, 247H, 249S, 250R, 253E, 254E, 259S, 260S, 263Y, 271D, 277S, 278I, 279M, 280P, 282K, 283K, 284N, 286D, 289E, 290L, 292R, 293G, 294K, 295T, 296G, 297R, 299F, 300G, 301H, 304A, 306F, 307T, 308T, 316Y, 317N, 318K, 319D, 322E, 325E, 336A, 339S, 366A, 371D, 380F, 381R, 384Y, 387V, 433R, 435T, 436F, 437G, 438S, 439P, 447H
CDD
cd01359 (Argininosuccinate_lyase)

246M

tetramer interface
97D, 100K, 103H, 104T, 153F, 154T, 155H, 156L, 157Q, 158K, 159A, 160Q, 166H, 170A, 171Y, 177R, 180Q, 181K, 184N, 188L, 199L, 200T, 201G, 202T, 203T, 205P, 208R, 222N, 223N, 224S, 225L, 226D, 229S, 230D, 232D, 236D, 239H, 243L, 246M, 247H, 249S, 250R, 253E, 254E, 259S, 260S, 263Y, 271D, 277S, 278I, 279M, 280P, 282K, 283K, 284N, 286D, 289E, 290L, 292R, 293G, 294K, 295T, 296G, 297R, 299F, 300G, 301H, 304A, 306F, 307T, 308T, 316Y, 317N, 318K, 319D, 322E, 325E, 336A, 339S, 366A, 371D, 380F, 381R, 384Y, 387V, 433R, 435T, 436F, 437G, 438S, 439P, 447H
CDD
cd01359 (Argininosuccinate_lyase)

247H

tetramer interface
97D, 100K, 103H, 104T, 153F, 154T, 155H, 156L, 157Q, 158K, 159A, 160Q, 166H, 170A, 171Y, 177R, 180Q, 181K, 184N, 188L, 199L, 200T, 201G, 202T, 203T, 205P, 208R, 222N, 223N, 224S, 225L, 226D, 229S, 230D, 232D, 236D, 239H, 243L, 246M, 247H, 249S, 250R, 253E, 254E, 259S, 260S, 263Y, 271D, 277S, 278I, 279M, 280P, 282K, 283K, 284N, 286D, 289E, 290L, 292R, 293G, 294K, 295T, 296G, 297R, 299F, 300G, 301H, 304A, 306F, 307T, 308T, 316Y, 317N, 318K, 319D, 322E, 325E, 336A, 339S, 366A, 371D, 380F, 381R, 384Y, 387V, 433R, 435T, 436F, 437G, 438S, 439P, 447H
CDD
cd01359 (Argininosuccinate_lyase)

249S

tetramer interface
97D, 100K, 103H, 104T, 153F, 154T, 155H, 156L, 157Q, 158K, 159A, 160Q, 166H, 170A, 171Y, 177R, 180Q, 181K, 184N, 188L, 199L, 200T, 201G, 202T, 203T, 205P, 208R, 222N, 223N, 224S, 225L, 226D, 229S, 230D, 232D, 236D, 239H, 243L, 246M, 247H, 249S, 250R, 253E, 254E, 259S, 260S, 263Y, 271D, 277S, 278I, 279M, 280P, 282K, 283K, 284N, 286D, 289E, 290L, 292R, 293G, 294K, 295T, 296G, 297R, 299F, 300G, 301H, 304A, 306F, 307T, 308T, 316Y, 317N, 318K, 319D, 322E, 325E, 336A, 339S, 366A, 371D, 380F, 381R, 384Y, 387V, 433R, 435T, 436F, 437G, 438S, 439P, 447H
CDD
cd01359 (Argininosuccinate_lyase)

250R

tetramer interface
97D, 100K, 103H, 104T, 153F, 154T, 155H, 156L, 157Q, 158K, 159A, 160Q, 166H, 170A, 171Y, 177R, 180Q, 181K, 184N, 188L, 199L, 200T, 201G, 202T, 203T, 205P, 208R, 222N, 223N, 224S, 225L, 226D, 229S, 230D, 232D, 236D, 239H, 243L, 246M, 247H, 249S, 250R, 253E, 254E, 259S, 260S, 263Y, 271D, 277S, 278I, 279M, 280P, 282K, 283K, 284N, 286D, 289E, 290L, 292R, 293G, 294K, 295T, 296G, 297R, 299F, 300G, 301H, 304A, 306F, 307T, 308T, 316Y, 317N, 318K, 319D, 322E, 325E, 336A, 339S, 366A, 371D, 380F, 381R, 384Y, 387V, 433R, 435T, 436F, 437G, 438S, 439P, 447H
CDD
cd01359 (Argininosuccinate_lyase)

253E

tetramer interface
97D, 100K, 103H, 104T, 153F, 154T, 155H, 156L, 157Q, 158K, 159A, 160Q, 166H, 170A, 171Y, 177R, 180Q, 181K, 184N, 188L, 199L, 200T, 201G, 202T, 203T, 205P, 208R, 222N, 223N, 224S, 225L, 226D, 229S, 230D, 232D, 236D, 239H, 243L, 246M, 247H, 249S, 250R, 253E, 254E, 259S, 260S, 263Y, 271D, 277S, 278I, 279M, 280P, 282K, 283K, 284N, 286D, 289E, 290L, 292R, 293G, 294K, 295T, 296G, 297R, 299F, 300G, 301H, 304A, 306F, 307T, 308T, 316Y, 317N, 318K, 319D, 322E, 325E, 336A, 339S, 366A, 371D, 380F, 381R, 384Y, 387V, 433R, 435T, 436F, 437G, 438S, 439P, 447H
CDD
cd01359 (Argininosuccinate_lyase)

254E

tetramer interface
97D, 100K, 103H, 104T, 153F, 154T, 155H, 156L, 157Q, 158K, 159A, 160Q, 166H, 170A, 171Y, 177R, 180Q, 181K, 184N, 188L, 199L, 200T, 201G, 202T, 203T, 205P, 208R, 222N, 223N, 224S, 225L, 226D, 229S, 230D, 232D, 236D, 239H, 243L, 246M, 247H, 249S, 250R, 253E, 254E, 259S, 260S, 263Y, 271D, 277S, 278I, 279M, 280P, 282K, 283K, 284N, 286D, 289E, 290L, 292R, 293G, 294K, 295T, 296G, 297R, 299F, 300G, 301H, 304A, 306F, 307T, 308T, 316Y, 317N, 318K, 319D, 322E, 325E, 336A, 339S, 366A, 371D, 380F, 381R, 384Y, 387V, 433R, 435T, 436F, 437G, 438S, 439P, 447H
CDD
cd01359 (Argininosuccinate_lyase)

259S

tetramer interface
97D, 100K, 103H, 104T, 153F, 154T, 155H, 156L, 157Q, 158K, 159A, 160Q, 166H, 170A, 171Y, 177R, 180Q, 181K, 184N, 188L, 199L, 200T, 201G, 202T, 203T, 205P, 208R, 222N, 223N, 224S, 225L, 226D, 229S, 230D, 232D, 236D, 239H, 243L, 246M, 247H, 249S, 250R, 253E, 254E, 259S, 260S, 263Y, 271D, 277S, 278I, 279M, 280P, 282K, 283K, 284N, 286D, 289E, 290L, 292R, 293G, 294K, 295T, 296G, 297R, 299F, 300G, 301H, 304A, 306F, 307T, 308T, 316Y, 317N, 318K, 319D, 322E, 325E, 336A, 339S, 366A, 371D, 380F, 381R, 384Y, 387V, 433R, 435T, 436F, 437G, 438S, 439P, 447H
CDD
cd01359 (Argininosuccinate_lyase)

260S

tetramer interface
97D, 100K, 103H, 104T, 153F, 154T, 155H, 156L, 157Q, 158K, 159A, 160Q, 166H, 170A, 171Y, 177R, 180Q, 181K, 184N, 188L, 199L, 200T, 201G, 202T, 203T, 205P, 208R, 222N, 223N, 224S, 225L, 226D, 229S, 230D, 232D, 236D, 239H, 243L, 246M, 247H, 249S, 250R, 253E, 254E, 259S, 260S, 263Y, 271D, 277S, 278I, 279M, 280P, 282K, 283K, 284N, 286D, 289E, 290L, 292R, 293G, 294K, 295T, 296G, 297R, 299F, 300G, 301H, 304A, 306F, 307T, 308T, 316Y, 317N, 318K, 319D, 322E, 325E, 336A, 339S, 366A, 371D, 380F, 381R, 384Y, 387V, 433R, 435T, 436F, 437G, 438S, 439P, 447H
CDD
cd01359 (Argininosuccinate_lyase)

263Y

tetramer interface
97D, 100K, 103H, 104T, 153F, 154T, 155H, 156L, 157Q, 158K, 159A, 160Q, 166H, 170A, 171Y, 177R, 180Q, 181K, 184N, 188L, 199L, 200T, 201G, 202T, 203T, 205P, 208R, 222N, 223N, 224S, 225L, 226D, 229S, 230D, 232D, 236D, 239H, 243L, 246M, 247H, 249S, 250R, 253E, 254E, 259S, 260S, 263Y, 271D, 277S, 278I, 279M, 280P, 282K, 283K, 284N, 286D, 289E, 290L, 292R, 293G, 294K, 295T, 296G, 297R, 299F, 300G, 301H, 304A, 306F, 307T, 308T, 316Y, 317N, 318K, 319D, 322E, 325E, 336A, 339S, 366A, 371D, 380F, 381R, 384Y, 387V, 433R, 435T, 436F, 437G, 438S, 439P, 447H
CDD
cd01359 (Argininosuccinate_lyase)

271D

tetramer interface
97D, 100K, 103H, 104T, 153F, 154T, 155H, 156L, 157Q, 158K, 159A, 160Q, 166H, 170A, 171Y, 177R, 180Q, 181K, 184N, 188L, 199L, 200T, 201G, 202T, 203T, 205P, 208R, 222N, 223N, 224S, 225L, 226D, 229S, 230D, 232D, 236D, 239H, 243L, 246M, 247H, 249S, 250R, 253E, 254E, 259S, 260S, 263Y, 271D, 277S, 278I, 279M, 280P, 282K, 283K, 284N, 286D, 289E, 290L, 292R, 293G, 294K, 295T, 296G, 297R, 299F, 300G, 301H, 304A, 306F, 307T, 308T, 316Y, 317N, 318K, 319D, 322E, 325E, 336A, 339S, 366A, 371D, 380F, 381R, 384Y, 387V, 433R, 435T, 436F, 437G, 438S, 439P, 447H
CDD
cd01359 (Argininosuccinate_lyase)

277S

tetramer interface
97D, 100K, 103H, 104T, 153F, 154T, 155H, 156L, 157Q, 158K, 159A, 160Q, 166H, 170A, 171Y, 177R, 180Q, 181K, 184N, 188L, 199L, 200T, 201G, 202T, 203T, 205P, 208R, 222N, 223N, 224S, 225L, 226D, 229S, 230D, 232D, 236D, 239H, 243L, 246M, 247H, 249S, 250R, 253E, 254E, 259S, 260S, 263Y, 271D, 277S, 278I, 279M, 280P, 282K, 283K, 284N, 286D, 289E, 290L, 292R, 293G, 294K, 295T, 296G, 297R, 299F, 300G, 301H, 304A, 306F, 307T, 308T, 316Y, 317N, 318K, 319D, 322E, 325E, 336A, 339S, 366A, 371D, 380F, 381R, 384Y, 387V, 433R, 435T, 436F, 437G, 438S, 439P, 447H
CDD
cd01359 (Argininosuccinate_lyase)

278I

tetramer interface
97D, 100K, 103H, 104T, 153F, 154T, 155H, 156L, 157Q, 158K, 159A, 160Q, 166H, 170A, 171Y, 177R, 180Q, 181K, 184N, 188L, 199L, 200T, 201G, 202T, 203T, 205P, 208R, 222N, 223N, 224S, 225L, 226D, 229S, 230D, 232D, 236D, 239H, 243L, 246M, 247H, 249S, 250R, 253E, 254E, 259S, 260S, 263Y, 271D, 277S, 278I, 279M, 280P, 282K, 283K, 284N, 286D, 289E, 290L, 292R, 293G, 294K, 295T, 296G, 297R, 299F, 300G, 301H, 304A, 306F, 307T, 308T, 316Y, 317N, 318K, 319D, 322E, 325E, 336A, 339S, 366A, 371D, 380F, 381R, 384Y, 387V, 433R, 435T, 436F, 437G, 438S, 439P, 447H
CDD
cd01359 (Argininosuccinate_lyase)

279M

tetramer interface
97D, 100K, 103H, 104T, 153F, 154T, 155H, 156L, 157Q, 158K, 159A, 160Q, 166H, 170A, 171Y, 177R, 180Q, 181K, 184N, 188L, 199L, 200T, 201G, 202T, 203T, 205P, 208R, 222N, 223N, 224S, 225L, 226D, 229S, 230D, 232D, 236D, 239H, 243L, 246M, 247H, 249S, 250R, 253E, 254E, 259S, 260S, 263Y, 271D, 277S, 278I, 279M, 280P, 282K, 283K, 284N, 286D, 289E, 290L, 292R, 293G, 294K, 295T, 296G, 297R, 299F, 300G, 301H, 304A, 306F, 307T, 308T, 316Y, 317N, 318K, 319D, 322E, 325E, 336A, 339S, 366A, 371D, 380F, 381R, 384Y, 387V, 433R, 435T, 436F, 437G, 438S, 439P, 447H
CDD
cd01359 (Argininosuccinate_lyase)

280P

tetramer interface
97D, 100K, 103H, 104T, 153F, 154T, 155H, 156L, 157Q, 158K, 159A, 160Q, 166H, 170A, 171Y, 177R, 180Q, 181K, 184N, 188L, 199L, 200T, 201G, 202T, 203T, 205P, 208R, 222N, 223N, 224S, 225L, 226D, 229S, 230D, 232D, 236D, 239H, 243L, 246M, 247H, 249S, 250R, 253E, 254E, 259S, 260S, 263Y, 271D, 277S, 278I, 279M, 280P, 282K, 283K, 284N, 286D, 289E, 290L, 292R, 293G, 294K, 295T, 296G, 297R, 299F, 300G, 301H, 304A, 306F, 307T, 308T, 316Y, 317N, 318K, 319D, 322E, 325E, 336A, 339S, 366A, 371D, 380F, 381R, 384Y, 387V, 433R, 435T, 436F, 437G, 438S, 439P, 447H
CDD
cd01359 (Argininosuccinate_lyase)

282K

tetramer interface
97D, 100K, 103H, 104T, 153F, 154T, 155H, 156L, 157Q, 158K, 159A, 160Q, 166H, 170A, 171Y, 177R, 180Q, 181K, 184N, 188L, 199L, 200T, 201G, 202T, 203T, 205P, 208R, 222N, 223N, 224S, 225L, 226D, 229S, 230D, 232D, 236D, 239H, 243L, 246M, 247H, 249S, 250R, 253E, 254E, 259S, 260S, 263Y, 271D, 277S, 278I, 279M, 280P, 282K, 283K, 284N, 286D, 289E, 290L, 292R, 293G, 294K, 295T, 296G, 297R, 299F, 300G, 301H, 304A, 306F, 307T, 308T, 316Y, 317N, 318K, 319D, 322E, 325E, 336A, 339S, 366A, 371D, 380F, 381R, 384Y, 387V, 433R, 435T, 436F, 437G, 438S, 439P, 447H
CDD
cd01359 (Argininosuccinate_lyase)

283K

tetramer interface
97D, 100K, 103H, 104T, 153F, 154T, 155H, 156L, 157Q, 158K, 159A, 160Q, 166H, 170A, 171Y, 177R, 180Q, 181K, 184N, 188L, 199L, 200T, 201G, 202T, 203T, 205P, 208R, 222N, 223N, 224S, 225L, 226D, 229S, 230D, 232D, 236D, 239H, 243L, 246M, 247H, 249S, 250R, 253E, 254E, 259S, 260S, 263Y, 271D, 277S, 278I, 279M, 280P, 282K, 283K, 284N, 286D, 289E, 290L, 292R, 293G, 294K, 295T, 296G, 297R, 299F, 300G, 301H, 304A, 306F, 307T, 308T, 316Y, 317N, 318K, 319D, 322E, 325E, 336A, 339S, 366A, 371D, 380F, 381R, 384Y, 387V, 433R, 435T, 436F, 437G, 438S, 439P, 447H
CDD
cd01359 (Argininosuccinate_lyase)

284N

tetramer interface
97D, 100K, 103H, 104T, 153F, 154T, 155H, 156L, 157Q, 158K, 159A, 160Q, 166H, 170A, 171Y, 177R, 180Q, 181K, 184N, 188L, 199L, 200T, 201G, 202T, 203T, 205P, 208R, 222N, 223N, 224S, 225L, 226D, 229S, 230D, 232D, 236D, 239H, 243L, 246M, 247H, 249S, 250R, 253E, 254E, 259S, 260S, 263Y, 271D, 277S, 278I, 279M, 280P, 282K, 283K, 284N, 286D, 289E, 290L, 292R, 293G, 294K, 295T, 296G, 297R, 299F, 300G, 301H, 304A, 306F, 307T, 308T, 316Y, 317N, 318K, 319D, 322E, 325E, 336A, 339S, 366A, 371D, 380F, 381R, 384Y, 387V, 433R, 435T, 436F, 437G, 438S, 439P, 447H
CDD
cd01359 (Argininosuccinate_lyase)

286D

tetramer interface
97D, 100K, 103H, 104T, 153F, 154T, 155H, 156L, 157Q, 158K, 159A, 160Q, 166H, 170A, 171Y, 177R, 180Q, 181K, 184N, 188L, 199L, 200T, 201G, 202T, 203T, 205P, 208R, 222N, 223N, 224S, 225L, 226D, 229S, 230D, 232D, 236D, 239H, 243L, 246M, 247H, 249S, 250R, 253E, 254E, 259S, 260S, 263Y, 271D, 277S, 278I, 279M, 280P, 282K, 283K, 284N, 286D, 289E, 290L, 292R, 293G, 294K, 295T, 296G, 297R, 299F, 300G, 301H, 304A, 306F, 307T, 308T, 316Y, 317N, 318K, 319D, 322E, 325E, 336A, 339S, 366A, 371D, 380F, 381R, 384Y, 387V, 433R, 435T, 436F, 437G, 438S, 439P, 447H
CDD
cd01359 (Argininosuccinate_lyase)

289E

tetramer interface
97D, 100K, 103H, 104T, 153F, 154T, 155H, 156L, 157Q, 158K, 159A, 160Q, 166H, 170A, 171Y, 177R, 180Q, 181K, 184N, 188L, 199L, 200T, 201G, 202T, 203T, 205P, 208R, 222N, 223N, 224S, 225L, 226D, 229S, 230D, 232D, 236D, 239H, 243L, 246M, 247H, 249S, 250R, 253E, 254E, 259S, 260S, 263Y, 271D, 277S, 278I, 279M, 280P, 282K, 283K, 284N, 286D, 289E, 290L, 292R, 293G, 294K, 295T, 296G, 297R, 299F, 300G, 301H, 304A, 306F, 307T, 308T, 316Y, 317N, 318K, 319D, 322E, 325E, 336A, 339S, 366A, 371D, 380F, 381R, 384Y, 387V, 433R, 435T, 436F, 437G, 438S, 439P, 447H
CDD
cd01359 (Argininosuccinate_lyase)

290L

tetramer interface
97D, 100K, 103H, 104T, 153F, 154T, 155H, 156L, 157Q, 158K, 159A, 160Q, 166H, 170A, 171Y, 177R, 180Q, 181K, 184N, 188L, 199L, 200T, 201G, 202T, 203T, 205P, 208R, 222N, 223N, 224S, 225L, 226D, 229S, 230D, 232D, 236D, 239H, 243L, 246M, 247H, 249S, 250R, 253E, 254E, 259S, 260S, 263Y, 271D, 277S, 278I, 279M, 280P, 282K, 283K, 284N, 286D, 289E, 290L, 292R, 293G, 294K, 295T, 296G, 297R, 299F, 300G, 301H, 304A, 306F, 307T, 308T, 316Y, 317N, 318K, 319D, 322E, 325E, 336A, 339S, 366A, 371D, 380F, 381R, 384Y, 387V, 433R, 435T, 436F, 437G, 438S, 439P, 447H
CDD
cd01359 (Argininosuccinate_lyase)

292R

tetramer interface
97D, 100K, 103H, 104T, 153F, 154T, 155H, 156L, 157Q, 158K, 159A, 160Q, 166H, 170A, 171Y, 177R, 180Q, 181K, 184N, 188L, 199L, 200T, 201G, 202T, 203T, 205P, 208R, 222N, 223N, 224S, 225L, 226D, 229S, 230D, 232D, 236D, 239H, 243L, 246M, 247H, 249S, 250R, 253E, 254E, 259S, 260S, 263Y, 271D, 277S, 278I, 279M, 280P, 282K, 283K, 284N, 286D, 289E, 290L, 292R, 293G, 294K, 295T, 296G, 297R, 299F, 300G, 301H, 304A, 306F, 307T, 308T, 316Y, 317N, 318K, 319D, 322E, 325E, 336A, 339S, 366A, 371D, 380F, 381R, 384Y, 387V, 433R, 435T, 436F, 437G, 438S, 439P, 447H
CDD
cd01359 (Argininosuccinate_lyase)

293G

tetramer interface
97D, 100K, 103H, 104T, 153F, 154T, 155H, 156L, 157Q, 158K, 159A, 160Q, 166H, 170A, 171Y, 177R, 180Q, 181K, 184N, 188L, 199L, 200T, 201G, 202T, 203T, 205P, 208R, 222N, 223N, 224S, 225L, 226D, 229S, 230D, 232D, 236D, 239H, 243L, 246M, 247H, 249S, 250R, 253E, 254E, 259S, 260S, 263Y, 271D, 277S, 278I, 279M, 280P, 282K, 283K, 284N, 286D, 289E, 290L, 292R, 293G, 294K, 295T, 296G, 297R, 299F, 300G, 301H, 304A, 306F, 307T, 308T, 316Y, 317N, 318K, 319D, 322E, 325E, 336A, 339S, 366A, 371D, 380F, 381R, 384Y, 387V, 433R, 435T, 436F, 437G, 438S, 439P, 447H
CDD
cd01359 (Argininosuccinate_lyase)

294K

tetramer interface
97D, 100K, 103H, 104T, 153F, 154T, 155H, 156L, 157Q, 158K, 159A, 160Q, 166H, 170A, 171Y, 177R, 180Q, 181K, 184N, 188L, 199L, 200T, 201G, 202T, 203T, 205P, 208R, 222N, 223N, 224S, 225L, 226D, 229S, 230D, 232D, 236D, 239H, 243L, 246M, 247H, 249S, 250R, 253E, 254E, 259S, 260S, 263Y, 271D, 277S, 278I, 279M, 280P, 282K, 283K, 284N, 286D, 289E, 290L, 292R, 293G, 294K, 295T, 296G, 297R, 299F, 300G, 301H, 304A, 306F, 307T, 308T, 316Y, 317N, 318K, 319D, 322E, 325E, 336A, 339S, 366A, 371D, 380F, 381R, 384Y, 387V, 433R, 435T, 436F, 437G, 438S, 439P, 447H
CDD
cd01359 (Argininosuccinate_lyase)

295T

tetramer interface
97D, 100K, 103H, 104T, 153F, 154T, 155H, 156L, 157Q, 158K, 159A, 160Q, 166H, 170A, 171Y, 177R, 180Q, 181K, 184N, 188L, 199L, 200T, 201G, 202T, 203T, 205P, 208R, 222N, 223N, 224S, 225L, 226D, 229S, 230D, 232D, 236D, 239H, 243L, 246M, 247H, 249S, 250R, 253E, 254E, 259S, 260S, 263Y, 271D, 277S, 278I, 279M, 280P, 282K, 283K, 284N, 286D, 289E, 290L, 292R, 293G, 294K, 295T, 296G, 297R, 299F, 300G, 301H, 304A, 306F, 307T, 308T, 316Y, 317N, 318K, 319D, 322E, 325E, 336A, 339S, 366A, 371D, 380F, 381R, 384Y, 387V, 433R, 435T, 436F, 437G, 438S, 439P, 447H
CDD
cd01359 (Argininosuccinate_lyase)

296G

tetramer interface
97D, 100K, 103H, 104T, 153F, 154T, 155H, 156L, 157Q, 158K, 159A, 160Q, 166H, 170A, 171Y, 177R, 180Q, 181K, 184N, 188L, 199L, 200T, 201G, 202T, 203T, 205P, 208R, 222N, 223N, 224S, 225L, 226D, 229S, 230D, 232D, 236D, 239H, 243L, 246M, 247H, 249S, 250R, 253E, 254E, 259S, 260S, 263Y, 271D, 277S, 278I, 279M, 280P, 282K, 283K, 284N, 286D, 289E, 290L, 292R, 293G, 294K, 295T, 296G, 297R, 299F, 300G, 301H, 304A, 306F, 307T, 308T, 316Y, 317N, 318K, 319D, 322E, 325E, 336A, 339S, 366A, 371D, 380F, 381R, 384Y, 387V, 433R, 435T, 436F, 437G, 438S, 439P, 447H
CDD
cd01359 (Argininosuccinate_lyase)

297R

tetramer interface
97D, 100K, 103H, 104T, 153F, 154T, 155H, 156L, 157Q, 158K, 159A, 160Q, 166H, 170A, 171Y, 177R, 180Q, 181K, 184N, 188L, 199L, 200T, 201G, 202T, 203T, 205P, 208R, 222N, 223N, 224S, 225L, 226D, 229S, 230D, 232D, 236D, 239H, 243L, 246M, 247H, 249S, 250R, 253E, 254E, 259S, 260S, 263Y, 271D, 277S, 278I, 279M, 280P, 282K, 283K, 284N, 286D, 289E, 290L, 292R, 293G, 294K, 295T, 296G, 297R, 299F, 300G, 301H, 304A, 306F, 307T, 308T, 316Y, 317N, 318K, 319D, 322E, 325E, 336A, 339S, 366A, 371D, 380F, 381R, 384Y, 387V, 433R, 435T, 436F, 437G, 438S, 439P, 447H
CDD
cd01359 (Argininosuccinate_lyase)

299F

tetramer interface
97D, 100K, 103H, 104T, 153F, 154T, 155H, 156L, 157Q, 158K, 159A, 160Q, 166H, 170A, 171Y, 177R, 180Q, 181K, 184N, 188L, 199L, 200T, 201G, 202T, 203T, 205P, 208R, 222N, 223N, 224S, 225L, 226D, 229S, 230D, 232D, 236D, 239H, 243L, 246M, 247H, 249S, 250R, 253E, 254E, 259S, 260S, 263Y, 271D, 277S, 278I, 279M, 280P, 282K, 283K, 284N, 286D, 289E, 290L, 292R, 293G, 294K, 295T, 296G, 297R, 299F, 300G, 301H, 304A, 306F, 307T, 308T, 316Y, 317N, 318K, 319D, 322E, 325E, 336A, 339S, 366A, 371D, 380F, 381R, 384Y, 387V, 433R, 435T, 436F, 437G, 438S, 439P, 447H
CDD
cd01359 (Argininosuccinate_lyase)

300G

tetramer interface
97D, 100K, 103H, 104T, 153F, 154T, 155H, 156L, 157Q, 158K, 159A, 160Q, 166H, 170A, 171Y, 177R, 180Q, 181K, 184N, 188L, 199L, 200T, 201G, 202T, 203T, 205P, 208R, 222N, 223N, 224S, 225L, 226D, 229S, 230D, 232D, 236D, 239H, 243L, 246M, 247H, 249S, 250R, 253E, 254E, 259S, 260S, 263Y, 271D, 277S, 278I, 279M, 280P, 282K, 283K, 284N, 286D, 289E, 290L, 292R, 293G, 294K, 295T, 296G, 297R, 299F, 300G, 301H, 304A, 306F, 307T, 308T, 316Y, 317N, 318K, 319D, 322E, 325E, 336A, 339S, 366A, 371D, 380F, 381R, 384Y, 387V, 433R, 435T, 436F, 437G, 438S, 439P, 447H
CDD
cd01359 (Argininosuccinate_lyase)

301H

tetramer interface
97D, 100K, 103H, 104T, 153F, 154T, 155H, 156L, 157Q, 158K, 159A, 160Q, 166H, 170A, 171Y, 177R, 180Q, 181K, 184N, 188L, 199L, 200T, 201G, 202T, 203T, 205P, 208R, 222N, 223N, 224S, 225L, 226D, 229S, 230D, 232D, 236D, 239H, 243L, 246M, 247H, 249S, 250R, 253E, 254E, 259S, 260S, 263Y, 271D, 277S, 278I, 279M, 280P, 282K, 283K, 284N, 286D, 289E, 290L, 292R, 293G, 294K, 295T, 296G, 297R, 299F, 300G, 301H, 304A, 306F, 307T, 308T, 316Y, 317N, 318K, 319D, 322E, 325E, 336A, 339S, 366A, 371D, 380F, 381R, 384Y, 387V, 433R, 435T, 436F, 437G, 438S, 439P, 447H
CDD
cd01359 (Argininosuccinate_lyase)

304A

tetramer interface
97D, 100K, 103H, 104T, 153F, 154T, 155H, 156L, 157Q, 158K, 159A, 160Q, 166H, 170A, 171Y, 177R, 180Q, 181K, 184N, 188L, 199L, 200T, 201G, 202T, 203T, 205P, 208R, 222N, 223N, 224S, 225L, 226D, 229S, 230D, 232D, 236D, 239H, 243L, 246M, 247H, 249S, 250R, 253E, 254E, 259S, 260S, 263Y, 271D, 277S, 278I, 279M, 280P, 282K, 283K, 284N, 286D, 289E, 290L, 292R, 293G, 294K, 295T, 296G, 297R, 299F, 300G, 301H, 304A, 306F, 307T, 308T, 316Y, 317N, 318K, 319D, 322E, 325E, 336A, 339S, 366A, 371D, 380F, 381R, 384Y, 387V, 433R, 435T, 436F, 437G, 438S, 439P, 447H
CDD
cd01359 (Argininosuccinate_lyase)

306F

tetramer interface
97D, 100K, 103H, 104T, 153F, 154T, 155H, 156L, 157Q, 158K, 159A, 160Q, 166H, 170A, 171Y, 177R, 180Q, 181K, 184N, 188L, 199L, 200T, 201G, 202T, 203T, 205P, 208R, 222N, 223N, 224S, 225L, 226D, 229S, 230D, 232D, 236D, 239H, 243L, 246M, 247H, 249S, 250R, 253E, 254E, 259S, 260S, 263Y, 271D, 277S, 278I, 279M, 280P, 282K, 283K, 284N, 286D, 289E, 290L, 292R, 293G, 294K, 295T, 296G, 297R, 299F, 300G, 301H, 304A, 306F, 307T, 308T, 316Y, 317N, 318K, 319D, 322E, 325E, 336A, 339S, 366A, 371D, 380F, 381R, 384Y, 387V, 433R, 435T, 436F, 437G, 438S, 439P, 447H
CDD
cd01359 (Argininosuccinate_lyase)

307T

tetramer interface
97D, 100K, 103H, 104T, 153F, 154T, 155H, 156L, 157Q, 158K, 159A, 160Q, 166H, 170A, 171Y, 177R, 180Q, 181K, 184N, 188L, 199L, 200T, 201G, 202T, 203T, 205P, 208R, 222N, 223N, 224S, 225L, 226D, 229S, 230D, 232D, 236D, 239H, 243L, 246M, 247H, 249S, 250R, 253E, 254E, 259S, 260S, 263Y, 271D, 277S, 278I, 279M, 280P, 282K, 283K, 284N, 286D, 289E, 290L, 292R, 293G, 294K, 295T, 296G, 297R, 299F, 300G, 301H, 304A, 306F, 307T, 308T, 316Y, 317N, 318K, 319D, 322E, 325E, 336A, 339S, 366A, 371D, 380F, 381R, 384Y, 387V, 433R, 435T, 436F, 437G, 438S, 439P, 447H
CDD
cd01359 (Argininosuccinate_lyase)

308T

tetramer interface
97D, 100K, 103H, 104T, 153F, 154T, 155H, 156L, 157Q, 158K, 159A, 160Q, 166H, 170A, 171Y, 177R, 180Q, 181K, 184N, 188L, 199L, 200T, 201G, 202T, 203T, 205P, 208R, 222N, 223N, 224S, 225L, 226D, 229S, 230D, 232D, 236D, 239H, 243L, 246M, 247H, 249S, 250R, 253E, 254E, 259S, 260S, 263Y, 271D, 277S, 278I, 279M, 280P, 282K, 283K, 284N, 286D, 289E, 290L, 292R, 293G, 294K, 295T, 296G, 297R, 299F, 300G, 301H, 304A, 306F, 307T, 308T, 316Y, 317N, 318K, 319D, 322E, 325E, 336A, 339S, 366A, 371D, 380F, 381R, 384Y, 387V, 433R, 435T, 436F, 437G, 438S, 439P, 447H
CDD
cd01359 (Argininosuccinate_lyase)

316Y

tetramer interface
97D, 100K, 103H, 104T, 153F, 154T, 155H, 156L, 157Q, 158K, 159A, 160Q, 166H, 170A, 171Y, 177R, 180Q, 181K, 184N, 188L, 199L, 200T, 201G, 202T, 203T, 205P, 208R, 222N, 223N, 224S, 225L, 226D, 229S, 230D, 232D, 236D, 239H, 243L, 246M, 247H, 249S, 250R, 253E, 254E, 259S, 260S, 263Y, 271D, 277S, 278I, 279M, 280P, 282K, 283K, 284N, 286D, 289E, 290L, 292R, 293G, 294K, 295T, 296G, 297R, 299F, 300G, 301H, 304A, 306F, 307T, 308T, 316Y, 317N, 318K, 319D, 322E, 325E, 336A, 339S, 366A, 371D, 380F, 381R, 384Y, 387V, 433R, 435T, 436F, 437G, 438S, 439P, 447H
CDD
cd01359 (Argininosuccinate_lyase)

317N

tetramer interface
97D, 100K, 103H, 104T, 153F, 154T, 155H, 156L, 157Q, 158K, 159A, 160Q, 166H, 170A, 171Y, 177R, 180Q, 181K, 184N, 188L, 199L, 200T, 201G, 202T, 203T, 205P, 208R, 222N, 223N, 224S, 225L, 226D, 229S, 230D, 232D, 236D, 239H, 243L, 246M, 247H, 249S, 250R, 253E, 254E, 259S, 260S, 263Y, 271D, 277S, 278I, 279M, 280P, 282K, 283K, 284N, 286D, 289E, 290L, 292R, 293G, 294K, 295T, 296G, 297R, 299F, 300G, 301H, 304A, 306F, 307T, 308T, 316Y, 317N, 318K, 319D, 322E, 325E, 336A, 339S, 366A, 371D, 380F, 381R, 384Y, 387V, 433R, 435T, 436F, 437G, 438S, 439P, 447H
CDD
cd01359 (Argininosuccinate_lyase)

318K

tetramer interface
97D, 100K, 103H, 104T, 153F, 154T, 155H, 156L, 157Q, 158K, 159A, 160Q, 166H, 170A, 171Y, 177R, 180Q, 181K, 184N, 188L, 199L, 200T, 201G, 202T, 203T, 205P, 208R, 222N, 223N, 224S, 225L, 226D, 229S, 230D, 232D, 236D, 239H, 243L, 246M, 247H, 249S, 250R, 253E, 254E, 259S, 260S, 263Y, 271D, 277S, 278I, 279M, 280P, 282K, 283K, 284N, 286D, 289E, 290L, 292R, 293G, 294K, 295T, 296G, 297R, 299F, 300G, 301H, 304A, 306F, 307T, 308T, 316Y, 317N, 318K, 319D, 322E, 325E, 336A, 339S, 366A, 371D, 380F, 381R, 384Y, 387V, 433R, 435T, 436F, 437G, 438S, 439P, 447H
CDD
cd01359 (Argininosuccinate_lyase)

319D

tetramer interface
97D, 100K, 103H, 104T, 153F, 154T, 155H, 156L, 157Q, 158K, 159A, 160Q, 166H, 170A, 171Y, 177R, 180Q, 181K, 184N, 188L, 199L, 200T, 201G, 202T, 203T, 205P, 208R, 222N, 223N, 224S, 225L, 226D, 229S, 230D, 232D, 236D, 239H, 243L, 246M, 247H, 249S, 250R, 253E, 254E, 259S, 260S, 263Y, 271D, 277S, 278I, 279M, 280P, 282K, 283K, 284N, 286D, 289E, 290L, 292R, 293G, 294K, 295T, 296G, 297R, 299F, 300G, 301H, 304A, 306F, 307T, 308T, 316Y, 317N, 318K, 319D, 322E, 325E, 336A, 339S, 366A, 371D, 380F, 381R, 384Y, 387V, 433R, 435T, 436F, 437G, 438S, 439P, 447H
CDD
cd01359 (Argininosuccinate_lyase)

322E

tetramer interface
97D, 100K, 103H, 104T, 153F, 154T, 155H, 156L, 157Q, 158K, 159A, 160Q, 166H, 170A, 171Y, 177R, 180Q, 181K, 184N, 188L, 199L, 200T, 201G, 202T, 203T, 205P, 208R, 222N, 223N, 224S, 225L, 226D, 229S, 230D, 232D, 236D, 239H, 243L, 246M, 247H, 249S, 250R, 253E, 254E, 259S, 260S, 263Y, 271D, 277S, 278I, 279M, 280P, 282K, 283K, 284N, 286D, 289E, 290L, 292R, 293G, 294K, 295T, 296G, 297R, 299F, 300G, 301H, 304A, 306F, 307T, 308T, 316Y, 317N, 318K, 319D, 322E, 325E, 336A, 339S, 366A, 371D, 380F, 381R, 384Y, 387V, 433R, 435T, 436F, 437G, 438S, 439P, 447H
CDD
cd01359 (Argininosuccinate_lyase)

325E

tetramer interface
97D, 100K, 103H, 104T, 153F, 154T, 155H, 156L, 157Q, 158K, 159A, 160Q, 166H, 170A, 171Y, 177R, 180Q, 181K, 184N, 188L, 199L, 200T, 201G, 202T, 203T, 205P, 208R, 222N, 223N, 224S, 225L, 226D, 229S, 230D, 232D, 236D, 239H, 243L, 246M, 247H, 249S, 250R, 253E, 254E, 259S, 260S, 263Y, 271D, 277S, 278I, 279M, 280P, 282K, 283K, 284N, 286D, 289E, 290L, 292R, 293G, 294K, 295T, 296G, 297R, 299F, 300G, 301H, 304A, 306F, 307T, 308T, 316Y, 317N, 318K, 319D, 322E, 325E, 336A, 339S, 366A, 371D, 380F, 381R, 384Y, 387V, 433R, 435T, 436F, 437G, 438S, 439P, 447H
CDD
cd01359 (Argininosuccinate_lyase)

336A

tetramer interface
97D, 100K, 103H, 104T, 153F, 154T, 155H, 156L, 157Q, 158K, 159A, 160Q, 166H, 170A, 171Y, 177R, 180Q, 181K, 184N, 188L, 199L, 200T, 201G, 202T, 203T, 205P, 208R, 222N, 223N, 224S, 225L, 226D, 229S, 230D, 232D, 236D, 239H, 243L, 246M, 247H, 249S, 250R, 253E, 254E, 259S, 260S, 263Y, 271D, 277S, 278I, 279M, 280P, 282K, 283K, 284N, 286D, 289E, 290L, 292R, 293G, 294K, 295T, 296G, 297R, 299F, 300G, 301H, 304A, 306F, 307T, 308T, 316Y, 317N, 318K, 319D, 322E, 325E, 336A, 339S, 366A, 371D, 380F, 381R, 384Y, 387V, 433R, 435T, 436F, 437G, 438S, 439P, 447H
CDD
cd01359 (Argininosuccinate_lyase)

339S

tetramer interface
97D, 100K, 103H, 104T, 153F, 154T, 155H, 156L, 157Q, 158K, 159A, 160Q, 166H, 170A, 171Y, 177R, 180Q, 181K, 184N, 188L, 199L, 200T, 201G, 202T, 203T, 205P, 208R, 222N, 223N, 224S, 225L, 226D, 229S, 230D, 232D, 236D, 239H, 243L, 246M, 247H, 249S, 250R, 253E, 254E, 259S, 260S, 263Y, 271D, 277S, 278I, 279M, 280P, 282K, 283K, 284N, 286D, 289E, 290L, 292R, 293G, 294K, 295T, 296G, 297R, 299F, 300G, 301H, 304A, 306F, 307T, 308T, 316Y, 317N, 318K, 319D, 322E, 325E, 336A, 339S, 366A, 371D, 380F, 381R, 384Y, 387V, 433R, 435T, 436F, 437G, 438S, 439P, 447H
CDD
cd01359 (Argininosuccinate_lyase)

366A

tetramer interface
97D, 100K, 103H, 104T, 153F, 154T, 155H, 156L, 157Q, 158K, 159A, 160Q, 166H, 170A, 171Y, 177R, 180Q, 181K, 184N, 188L, 199L, 200T, 201G, 202T, 203T, 205P, 208R, 222N, 223N, 224S, 225L, 226D, 229S, 230D, 232D, 236D, 239H, 243L, 246M, 247H, 249S, 250R, 253E, 254E, 259S, 260S, 263Y, 271D, 277S, 278I, 279M, 280P, 282K, 283K, 284N, 286D, 289E, 290L, 292R, 293G, 294K, 295T, 296G, 297R, 299F, 300G, 301H, 304A, 306F, 307T, 308T, 316Y, 317N, 318K, 319D, 322E, 325E, 336A, 339S, 366A, 371D, 380F, 381R, 384Y, 387V, 433R, 435T, 436F, 437G, 438S, 439P, 447H
CDD
cd01359 (Argininosuccinate_lyase)

371D

tetramer interface
97D, 100K, 103H, 104T, 153F, 154T, 155H, 156L, 157Q, 158K, 159A, 160Q, 166H, 170A, 171Y, 177R, 180Q, 181K, 184N, 188L, 199L, 200T, 201G, 202T, 203T, 205P, 208R, 222N, 223N, 224S, 225L, 226D, 229S, 230D, 232D, 236D, 239H, 243L, 246M, 247H, 249S, 250R, 253E, 254E, 259S, 260S, 263Y, 271D, 277S, 278I, 279M, 280P, 282K, 283K, 284N, 286D, 289E, 290L, 292R, 293G, 294K, 295T, 296G, 297R, 299F, 300G, 301H, 304A, 306F, 307T, 308T, 316Y, 317N, 318K, 319D, 322E, 325E, 336A, 339S, 366A, 371D, 380F, 381R, 384Y, 387V, 433R, 435T, 436F, 437G, 438S, 439P, 447H
CDD
cd01359 (Argininosuccinate_lyase)

380F

tetramer interface
97D, 100K, 103H, 104T, 153F, 154T, 155H, 156L, 157Q, 158K, 159A, 160Q, 166H, 170A, 171Y, 177R, 180Q, 181K, 184N, 188L, 199L, 200T, 201G, 202T, 203T, 205P, 208R, 222N, 223N, 224S, 225L, 226D, 229S, 230D, 232D, 236D, 239H, 243L, 246M, 247H, 249S, 250R, 253E, 254E, 259S, 260S, 263Y, 271D, 277S, 278I, 279M, 280P, 282K, 283K, 284N, 286D, 289E, 290L, 292R, 293G, 294K, 295T, 296G, 297R, 299F, 300G, 301H, 304A, 306F, 307T, 308T, 316Y, 317N, 318K, 319D, 322E, 325E, 336A, 339S, 366A, 371D, 380F, 381R, 384Y, 387V, 433R, 435T, 436F, 437G, 438S, 439P, 447H
CDD
cd01359 (Argininosuccinate_lyase)

381R

tetramer interface
97D, 100K, 103H, 104T, 153F, 154T, 155H, 156L, 157Q, 158K, 159A, 160Q, 166H, 170A, 171Y, 177R, 180Q, 181K, 184N, 188L, 199L, 200T, 201G, 202T, 203T, 205P, 208R, 222N, 223N, 224S, 225L, 226D, 229S, 230D, 232D, 236D, 239H, 243L, 246M, 247H, 249S, 250R, 253E, 254E, 259S, 260S, 263Y, 271D, 277S, 278I, 279M, 280P, 282K, 283K, 284N, 286D, 289E, 290L, 292R, 293G, 294K, 295T, 296G, 297R, 299F, 300G, 301H, 304A, 306F, 307T, 308T, 316Y, 317N, 318K, 319D, 322E, 325E, 336A, 339S, 366A, 371D, 380F, 381R, 384Y, 387V, 433R, 435T, 436F, 437G, 438S, 439P, 447H
CDD
cd01359 (Argininosuccinate_lyase)

384Y

tetramer interface
97D, 100K, 103H, 104T, 153F, 154T, 155H, 156L, 157Q, 158K, 159A, 160Q, 166H, 170A, 171Y, 177R, 180Q, 181K, 184N, 188L, 199L, 200T, 201G, 202T, 203T, 205P, 208R, 222N, 223N, 224S, 225L, 226D, 229S, 230D, 232D, 236D, 239H, 243L, 246M, 247H, 249S, 250R, 253E, 254E, 259S, 260S, 263Y, 271D, 277S, 278I, 279M, 280P, 282K, 283K, 284N, 286D, 289E, 290L, 292R, 293G, 294K, 295T, 296G, 297R, 299F, 300G, 301H, 304A, 306F, 307T, 308T, 316Y, 317N, 318K, 319D, 322E, 325E, 336A, 339S, 366A, 371D, 380F, 381R, 384Y, 387V, 433R, 435T, 436F, 437G, 438S, 439P, 447H
CDD
cd01359 (Argininosuccinate_lyase)

387V

tetramer interface
97D, 100K, 103H, 104T, 153F, 154T, 155H, 156L, 157Q, 158K, 159A, 160Q, 166H, 170A, 171Y, 177R, 180Q, 181K, 184N, 188L, 199L, 200T, 201G, 202T, 203T, 205P, 208R, 222N, 223N, 224S, 225L, 226D, 229S, 230D, 232D, 236D, 239H, 243L, 246M, 247H, 249S, 250R, 253E, 254E, 259S, 260S, 263Y, 271D, 277S, 278I, 279M, 280P, 282K, 283K, 284N, 286D, 289E, 290L, 292R, 293G, 294K, 295T, 296G, 297R, 299F, 300G, 301H, 304A, 306F, 307T, 308T, 316Y, 317N, 318K, 319D, 322E, 325E, 336A, 339S, 366A, 371D, 380F, 381R, 384Y, 387V, 433R, 435T, 436F, 437G, 438S, 439P, 447H
CDD
cd01359 (Argininosuccinate_lyase)

433R

tetramer interface
97D, 100K, 103H, 104T, 153F, 154T, 155H, 156L, 157Q, 158K, 159A, 160Q, 166H, 170A, 171Y, 177R, 180Q, 181K, 184N, 188L, 199L, 200T, 201G, 202T, 203T, 205P, 208R, 222N, 223N, 224S, 225L, 226D, 229S, 230D, 232D, 236D, 239H, 243L, 246M, 247H, 249S, 250R, 253E, 254E, 259S, 260S, 263Y, 271D, 277S, 278I, 279M, 280P, 282K, 283K, 284N, 286D, 289E, 290L, 292R, 293G, 294K, 295T, 296G, 297R, 299F, 300G, 301H, 304A, 306F, 307T, 308T, 316Y, 317N, 318K, 319D, 322E, 325E, 336A, 339S, 366A, 371D, 380F, 381R, 384Y, 387V, 433R, 435T, 436F, 437G, 438S, 439P, 447H
CDD
cd01359 (Argininosuccinate_lyase)

435T

tetramer interface
97D, 100K, 103H, 104T, 153F, 154T, 155H, 156L, 157Q, 158K, 159A, 160Q, 166H, 170A, 171Y, 177R, 180Q, 181K, 184N, 188L, 199L, 200T, 201G, 202T, 203T, 205P, 208R, 222N, 223N, 224S, 225L, 226D, 229S, 230D, 232D, 236D, 239H, 243L, 246M, 247H, 249S, 250R, 253E, 254E, 259S, 260S, 263Y, 271D, 277S, 278I, 279M, 280P, 282K, 283K, 284N, 286D, 289E, 290L, 292R, 293G, 294K, 295T, 296G, 297R, 299F, 300G, 301H, 304A, 306F, 307T, 308T, 316Y, 317N, 318K, 319D, 322E, 325E, 336A, 339S, 366A, 371D, 380F, 381R, 384Y, 387V, 433R, 435T, 436F, 437G, 438S, 439P, 447H
CDD
cd01359 (Argininosuccinate_lyase)

436F

tetramer interface
97D, 100K, 103H, 104T, 153F, 154T, 155H, 156L, 157Q, 158K, 159A, 160Q, 166H, 170A, 171Y, 177R, 180Q, 181K, 184N, 188L, 199L, 200T, 201G, 202T, 203T, 205P, 208R, 222N, 223N, 224S, 225L, 226D, 229S, 230D, 232D, 236D, 239H, 243L, 246M, 247H, 249S, 250R, 253E, 254E, 259S, 260S, 263Y, 271D, 277S, 278I, 279M, 280P, 282K, 283K, 284N, 286D, 289E, 290L, 292R, 293G, 294K, 295T, 296G, 297R, 299F, 300G, 301H, 304A, 306F, 307T, 308T, 316Y, 317N, 318K, 319D, 322E, 325E, 336A, 339S, 366A, 371D, 380F, 381R, 384Y, 387V, 433R, 435T, 436F, 437G, 438S, 439P, 447H
CDD
cd01359 (Argininosuccinate_lyase)

437G

tetramer interface
97D, 100K, 103H, 104T, 153F, 154T, 155H, 156L, 157Q, 158K, 159A, 160Q, 166H, 170A, 171Y, 177R, 180Q, 181K, 184N, 188L, 199L, 200T, 201G, 202T, 203T, 205P, 208R, 222N, 223N, 224S, 225L, 226D, 229S, 230D, 232D, 236D, 239H, 243L, 246M, 247H, 249S, 250R, 253E, 254E, 259S, 260S, 263Y, 271D, 277S, 278I, 279M, 280P, 282K, 283K, 284N, 286D, 289E, 290L, 292R, 293G, 294K, 295T, 296G, 297R, 299F, 300G, 301H, 304A, 306F, 307T, 308T, 316Y, 317N, 318K, 319D, 322E, 325E, 336A, 339S, 366A, 371D, 380F, 381R, 384Y, 387V, 433R, 435T, 436F, 437G, 438S, 439P, 447H
CDD
cd01359 (Argininosuccinate_lyase)

438S

tetramer interface
97D, 100K, 103H, 104T, 153F, 154T, 155H, 156L, 157Q, 158K, 159A, 160Q, 166H, 170A, 171Y, 177R, 180Q, 181K, 184N, 188L, 199L, 200T, 201G, 202T, 203T, 205P, 208R, 222N, 223N, 224S, 225L, 226D, 229S, 230D, 232D, 236D, 239H, 243L, 246M, 247H, 249S, 250R, 253E, 254E, 259S, 260S, 263Y, 271D, 277S, 278I, 279M, 280P, 282K, 283K, 284N, 286D, 289E, 290L, 292R, 293G, 294K, 295T, 296G, 297R, 299F, 300G, 301H, 304A, 306F, 307T, 308T, 316Y, 317N, 318K, 319D, 322E, 325E, 336A, 339S, 366A, 371D, 380F, 381R, 384Y, 387V, 433R, 435T, 436F, 437G, 438S, 439P, 447H
CDD
cd01359 (Argininosuccinate_lyase)

439P

tetramer interface
97D, 100K, 103H, 104T, 153F, 154T, 155H, 156L, 157Q, 158K, 159A, 160Q, 166H, 170A, 171Y, 177R, 180Q, 181K, 184N, 188L, 199L, 200T, 201G, 202T, 203T, 205P, 208R, 222N, 223N, 224S, 225L, 226D, 229S, 230D, 232D, 236D, 239H, 243L, 246M, 247H, 249S, 250R, 253E, 254E, 259S, 260S, 263Y, 271D, 277S, 278I, 279M, 280P, 282K, 283K, 284N, 286D, 289E, 290L, 292R, 293G, 294K, 295T, 296G, 297R, 299F, 300G, 301H, 304A, 306F, 307T, 308T, 316Y, 317N, 318K, 319D, 322E, 325E, 336A, 339S, 366A, 371D, 380F, 381R, 384Y, 387V, 433R, 435T, 436F, 437G, 438S, 439P, 447H
CDD
cd01359 (Argininosuccinate_lyase)

447H

tetramer interface
97D, 100K, 103H, 104T, 153F, 154T, 155H, 156L, 157Q, 158K, 159A, 160Q, 166H, 170A, 171Y, 177R, 180Q, 181K, 184N, 188L, 199L, 200T, 201G, 202T, 203T, 205P, 208R, 222N, 223N, 224S, 225L, 226D, 229S, 230D, 232D, 236D, 239H, 243L, 246M, 247H, 249S, 250R, 253E, 254E, 259S, 260S, 263Y, 271D, 277S, 278I, 279M, 280P, 282K, 283K, 284N, 286D, 289E, 290L, 292R, 293G, 294K, 295T, 296G, 297R, 299F, 300G, 301H, 304A, 306F, 307T, 308T, 316Y, 317N, 318K, 319D, 322E, 325E, 336A, 339S, 366A, 371D, 380F, 381R, 384Y, 387V, 433R, 435T, 436F, 437G, 438S, 439P, 447H
CDD
cd01359 (Argininosuccinate_lyase)

GO term prediction

Biological Process

GO:0042450 arginine biosynthetic process via ornithine

Molecular Function

GO:0003824 catalytic activity
GO:0004056 argininosuccinate lyase activity

Cellular Component

None predicted.

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Entry type

Status

Per-residue features

1_1_36S_FusoPortal_Gene_447

Protein family membership

Homologous superfamilies

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component