23726_FusoPortal_Gene_1129

Protein

23726_FusoPortal_Gene_1129

Length

534 amino acids

Protein family membership

Bifunctional CTP:phosphocholine cytidylyltransferase/choline kinase (IPR017190)

Homologous superfamilies

Homologous superfamily
1 - 239
Nucleotide-diphospho-sugar transferases (IPR029044)
Homologous superfamily
237 - 526
Protein kinase-like domain superfamily (IPR011009)

1 50 100 150 200 250 300 350 400 450 500 534

Domains and repeats

Domain
3 - 108
Nucleotidyl transferase domain (IPR005835)

1 50 100 150 200 250 300 350 400 450 500 534

Detailed signature matches

IPR029044

Nucleotide-diphospho-sugar transferases
1. G3DSA:3.90.55...
  
  1 - 231
  
  GENE3D
  G3DSA:3.90.550.10 (G3DSA:3.90.550.10)
2. SSF53448 (Nucleotid...)
  
  1 - 239
  
  SUPERFAMILY
  SSF53448 (Nucleotide-diphospho-sugar transferases)
IPR011009

Protein kinase-like domain superfamily
1. SSF56112 (Protein k...)
  
  237 - 526
  
  SUPERFAMILY
  SSF56112 (Protein kinase-like (PK-like))
IPR017190

Bifunctional CTP:phosphocholine cytidylyltransferase/choline kinase
1. PIRSF037383 (LicCA)
  
  1 - 531
  
  PIRSF
  PIRSF037383 (LicCA)
IPR005835

Nucleotidyl transferase domain
1. PF00483 (NTP_transf...)
  
  3 - 108
  
  Pfam
  PF00483 (NTP_transferase)

no IPR

Unintegrated signatures

G3DSA:3.30.20...

238 - 295

GENE3D
G3DSA:3.30.200.20 (G3DSA:3.30.200.20)
G3DSA:3.90.12...

296 - 527

GENE3D
G3DSA:3.90.1200.10 (G3DSA:3.90.1200.10)
PF01633 (Choline_ki...)

278 - 466

Pfam
PF01633 (Choline_kinase)
PTHR22603 (CHOLINE/...)

168 - 527

PANTHER
PTHR22603 (CHOLINE/ETHANOALAMINE KINASE)
PTHR22603:SF66 (ETH...)

168 - 527

PANTHER
PTHR22603:SF66 (ETHANOLAMINE KINASE 2)
cd02523 (PC_cytidyl...)

3 - 222

CDD
cd02523 (PC_cytidylyltransferase)
cd05151 (ChoK-like)

261 - 456

CDD
cd05151 (ChoK-like)

Residue annotation

active site cd02523

6I

active site
6I, 7A, 8A, 9G, 82N, 83N, 86S, 102G, 103D, 132W, 187Y, 189D, 213E, 215D
CDD
cd02523 (PC_cytidylyltransferase)

7A

active site
6I, 7A, 8A, 9G, 82N, 83N, 86S, 102G, 103D, 132W, 187Y, 189D, 213E, 215D
CDD
cd02523 (PC_cytidylyltransferase)

8A

active site
6I, 7A, 8A, 9G, 82N, 83N, 86S, 102G, 103D, 132W, 187Y, 189D, 213E, 215D
CDD
cd02523 (PC_cytidylyltransferase)

9G

active site
6I, 7A, 8A, 9G, 82N, 83N, 86S, 102G, 103D, 132W, 187Y, 189D, 213E, 215D
CDD
cd02523 (PC_cytidylyltransferase)

82N

active site
6I, 7A, 8A, 9G, 82N, 83N, 86S, 102G, 103D, 132W, 187Y, 189D, 213E, 215D
CDD
cd02523 (PC_cytidylyltransferase)

83N

active site
6I, 7A, 8A, 9G, 82N, 83N, 86S, 102G, 103D, 132W, 187Y, 189D, 213E, 215D
CDD
cd02523 (PC_cytidylyltransferase)

86S

active site
6I, 7A, 8A, 9G, 82N, 83N, 86S, 102G, 103D, 132W, 187Y, 189D, 213E, 215D
CDD
cd02523 (PC_cytidylyltransferase)

102G

active site
6I, 7A, 8A, 9G, 82N, 83N, 86S, 102G, 103D, 132W, 187Y, 189D, 213E, 215D
CDD
cd02523 (PC_cytidylyltransferase)

103D

active site
6I, 7A, 8A, 9G, 82N, 83N, 86S, 102G, 103D, 132W, 187Y, 189D, 213E, 215D
CDD
cd02523 (PC_cytidylyltransferase)

132W

active site
6I, 7A, 8A, 9G, 82N, 83N, 86S, 102G, 103D, 132W, 187Y, 189D, 213E, 215D
CDD
cd02523 (PC_cytidylyltransferase)

187Y

active site
6I, 7A, 8A, 9G, 82N, 83N, 86S, 102G, 103D, 132W, 187Y, 189D, 213E, 215D
CDD
cd02523 (PC_cytidylyltransferase)

189D

active site
6I, 7A, 8A, 9G, 82N, 83N, 86S, 102G, 103D, 132W, 187Y, 189D, 213E, 215D
CDD
cd02523 (PC_cytidylyltransferase)

213E

active site
6I, 7A, 8A, 9G, 82N, 83N, 86S, 102G, 103D, 132W, 187Y, 189D, 213E, 215D
CDD
cd02523 (PC_cytidylyltransferase)

215D

active site
6I, 7A, 8A, 9G, 82N, 83N, 86S, 102G, 103D, 132W, 187Y, 189D, 213E, 215D
CDD
cd02523 (PC_cytidylyltransferase)
metal binding site...

103D

metal binding site
103D, 213E, 215D
CDD
cd02523 (PC_cytidylyltransferase)

213E

metal binding site
103D, 213E, 215D
CDD
cd02523 (PC_cytidylyltransferase)

215D

metal binding site
103D, 213E, 215D
CDD
cd02523 (PC_cytidylyltransferase)
ATP binding site c...

264I

ATP binding site
264I, 269N, 271N, 282V, 284R, 313S, 327S, 328E, 329Y, 330I, 332N, 333S, 334E, 421E, 424L, 433I, 434D
CDD
cd05151 (ChoK-like)

269N

ATP binding site
264I, 269N, 271N, 282V, 284R, 313S, 327S, 328E, 329Y, 330I, 332N, 333S, 334E, 421E, 424L, 433I, 434D
CDD
cd05151 (ChoK-like)

271N

ATP binding site
264I, 269N, 271N, 282V, 284R, 313S, 327S, 328E, 329Y, 330I, 332N, 333S, 334E, 421E, 424L, 433I, 434D
CDD
cd05151 (ChoK-like)

282V

ATP binding site
264I, 269N, 271N, 282V, 284R, 313S, 327S, 328E, 329Y, 330I, 332N, 333S, 334E, 421E, 424L, 433I, 434D
CDD
cd05151 (ChoK-like)

284R

ATP binding site
264I, 269N, 271N, 282V, 284R, 313S, 327S, 328E, 329Y, 330I, 332N, 333S, 334E, 421E, 424L, 433I, 434D
CDD
cd05151 (ChoK-like)

313S

ATP binding site
264I, 269N, 271N, 282V, 284R, 313S, 327S, 328E, 329Y, 330I, 332N, 333S, 334E, 421E, 424L, 433I, 434D
CDD
cd05151 (ChoK-like)

327S

ATP binding site
264I, 269N, 271N, 282V, 284R, 313S, 327S, 328E, 329Y, 330I, 332N, 333S, 334E, 421E, 424L, 433I, 434D
CDD
cd05151 (ChoK-like)

328E

ATP binding site
264I, 269N, 271N, 282V, 284R, 313S, 327S, 328E, 329Y, 330I, 332N, 333S, 334E, 421E, 424L, 433I, 434D
CDD
cd05151 (ChoK-like)

329Y

ATP binding site
264I, 269N, 271N, 282V, 284R, 313S, 327S, 328E, 329Y, 330I, 332N, 333S, 334E, 421E, 424L, 433I, 434D
CDD
cd05151 (ChoK-like)

330I

ATP binding site
264I, 269N, 271N, 282V, 284R, 313S, 327S, 328E, 329Y, 330I, 332N, 333S, 334E, 421E, 424L, 433I, 434D
CDD
cd05151 (ChoK-like)

332N

ATP binding site
264I, 269N, 271N, 282V, 284R, 313S, 327S, 328E, 329Y, 330I, 332N, 333S, 334E, 421E, 424L, 433I, 434D
CDD
cd05151 (ChoK-like)

333S

ATP binding site
264I, 269N, 271N, 282V, 284R, 313S, 327S, 328E, 329Y, 330I, 332N, 333S, 334E, 421E, 424L, 433I, 434D
CDD
cd05151 (ChoK-like)

334E

ATP binding site
264I, 269N, 271N, 282V, 284R, 313S, 327S, 328E, 329Y, 330I, 332N, 333S, 334E, 421E, 424L, 433I, 434D
CDD
cd05151 (ChoK-like)

421E

ATP binding site
264I, 269N, 271N, 282V, 284R, 313S, 327S, 328E, 329Y, 330I, 332N, 333S, 334E, 421E, 424L, 433I, 434D
CDD
cd05151 (ChoK-like)

424L

ATP binding site
264I, 269N, 271N, 282V, 284R, 313S, 327S, 328E, 329Y, 330I, 332N, 333S, 334E, 421E, 424L, 433I, 434D
CDD
cd05151 (ChoK-like)

433I

ATP binding site
264I, 269N, 271N, 282V, 284R, 313S, 327S, 328E, 329Y, 330I, 332N, 333S, 334E, 421E, 424L, 433I, 434D
CDD
cd05151 (ChoK-like)

434D

ATP binding site
264I, 269N, 271N, 282V, 284R, 313S, 327S, 328E, 329Y, 330I, 332N, 333S, 334E, 421E, 424L, 433I, 434D
CDD
cd05151 (ChoK-like)
active site cd05151

264I

active site
264I, 266G, 267M, 268T, 269N, 271N, 282V, 284R, 313S, 327S, 328E, 329Y, 330I, 332N, 333S, 334E, 417D, 419V, 421E, 422N, 424L, 433I, 434D, 437Y, 453E
CDD
cd05151 (ChoK-like)

266G

active site
264I, 266G, 267M, 268T, 269N, 271N, 282V, 284R, 313S, 327S, 328E, 329Y, 330I, 332N, 333S, 334E, 417D, 419V, 421E, 422N, 424L, 433I, 434D, 437Y, 453E
CDD
cd05151 (ChoK-like)

267M

active site
264I, 266G, 267M, 268T, 269N, 271N, 282V, 284R, 313S, 327S, 328E, 329Y, 330I, 332N, 333S, 334E, 417D, 419V, 421E, 422N, 424L, 433I, 434D, 437Y, 453E
CDD
cd05151 (ChoK-like)

268T

active site
264I, 266G, 267M, 268T, 269N, 271N, 282V, 284R, 313S, 327S, 328E, 329Y, 330I, 332N, 333S, 334E, 417D, 419V, 421E, 422N, 424L, 433I, 434D, 437Y, 453E
CDD
cd05151 (ChoK-like)

269N

active site
264I, 266G, 267M, 268T, 269N, 271N, 282V, 284R, 313S, 327S, 328E, 329Y, 330I, 332N, 333S, 334E, 417D, 419V, 421E, 422N, 424L, 433I, 434D, 437Y, 453E
CDD
cd05151 (ChoK-like)

271N

active site
264I, 266G, 267M, 268T, 269N, 271N, 282V, 284R, 313S, 327S, 328E, 329Y, 330I, 332N, 333S, 334E, 417D, 419V, 421E, 422N, 424L, 433I, 434D, 437Y, 453E
CDD
cd05151 (ChoK-like)

282V

active site
264I, 266G, 267M, 268T, 269N, 271N, 282V, 284R, 313S, 327S, 328E, 329Y, 330I, 332N, 333S, 334E, 417D, 419V, 421E, 422N, 424L, 433I, 434D, 437Y, 453E
CDD
cd05151 (ChoK-like)

284R

active site
264I, 266G, 267M, 268T, 269N, 271N, 282V, 284R, 313S, 327S, 328E, 329Y, 330I, 332N, 333S, 334E, 417D, 419V, 421E, 422N, 424L, 433I, 434D, 437Y, 453E
CDD
cd05151 (ChoK-like)

313S

active site
264I, 266G, 267M, 268T, 269N, 271N, 282V, 284R, 313S, 327S, 328E, 329Y, 330I, 332N, 333S, 334E, 417D, 419V, 421E, 422N, 424L, 433I, 434D, 437Y, 453E
CDD
cd05151 (ChoK-like)

327S

active site
264I, 266G, 267M, 268T, 269N, 271N, 282V, 284R, 313S, 327S, 328E, 329Y, 330I, 332N, 333S, 334E, 417D, 419V, 421E, 422N, 424L, 433I, 434D, 437Y, 453E
CDD
cd05151 (ChoK-like)

328E

active site
264I, 266G, 267M, 268T, 269N, 271N, 282V, 284R, 313S, 327S, 328E, 329Y, 330I, 332N, 333S, 334E, 417D, 419V, 421E, 422N, 424L, 433I, 434D, 437Y, 453E
CDD
cd05151 (ChoK-like)

329Y

active site
264I, 266G, 267M, 268T, 269N, 271N, 282V, 284R, 313S, 327S, 328E, 329Y, 330I, 332N, 333S, 334E, 417D, 419V, 421E, 422N, 424L, 433I, 434D, 437Y, 453E
CDD
cd05151 (ChoK-like)

330I

active site
264I, 266G, 267M, 268T, 269N, 271N, 282V, 284R, 313S, 327S, 328E, 329Y, 330I, 332N, 333S, 334E, 417D, 419V, 421E, 422N, 424L, 433I, 434D, 437Y, 453E
CDD
cd05151 (ChoK-like)

332N

active site
264I, 266G, 267M, 268T, 269N, 271N, 282V, 284R, 313S, 327S, 328E, 329Y, 330I, 332N, 333S, 334E, 417D, 419V, 421E, 422N, 424L, 433I, 434D, 437Y, 453E
CDD
cd05151 (ChoK-like)

333S

active site
264I, 266G, 267M, 268T, 269N, 271N, 282V, 284R, 313S, 327S, 328E, 329Y, 330I, 332N, 333S, 334E, 417D, 419V, 421E, 422N, 424L, 433I, 434D, 437Y, 453E
CDD
cd05151 (ChoK-like)

334E

active site
264I, 266G, 267M, 268T, 269N, 271N, 282V, 284R, 313S, 327S, 328E, 329Y, 330I, 332N, 333S, 334E, 417D, 419V, 421E, 422N, 424L, 433I, 434D, 437Y, 453E
CDD
cd05151 (ChoK-like)

417D

active site
264I, 266G, 267M, 268T, 269N, 271N, 282V, 284R, 313S, 327S, 328E, 329Y, 330I, 332N, 333S, 334E, 417D, 419V, 421E, 422N, 424L, 433I, 434D, 437Y, 453E
CDD
cd05151 (ChoK-like)

419V

active site
264I, 266G, 267M, 268T, 269N, 271N, 282V, 284R, 313S, 327S, 328E, 329Y, 330I, 332N, 333S, 334E, 417D, 419V, 421E, 422N, 424L, 433I, 434D, 437Y, 453E
CDD
cd05151 (ChoK-like)

421E

active site
264I, 266G, 267M, 268T, 269N, 271N, 282V, 284R, 313S, 327S, 328E, 329Y, 330I, 332N, 333S, 334E, 417D, 419V, 421E, 422N, 424L, 433I, 434D, 437Y, 453E
CDD
cd05151 (ChoK-like)

422N

active site
264I, 266G, 267M, 268T, 269N, 271N, 282V, 284R, 313S, 327S, 328E, 329Y, 330I, 332N, 333S, 334E, 417D, 419V, 421E, 422N, 424L, 433I, 434D, 437Y, 453E
CDD
cd05151 (ChoK-like)

424L

active site
264I, 266G, 267M, 268T, 269N, 271N, 282V, 284R, 313S, 327S, 328E, 329Y, 330I, 332N, 333S, 334E, 417D, 419V, 421E, 422N, 424L, 433I, 434D, 437Y, 453E
CDD
cd05151 (ChoK-like)

433I

active site
264I, 266G, 267M, 268T, 269N, 271N, 282V, 284R, 313S, 327S, 328E, 329Y, 330I, 332N, 333S, 334E, 417D, 419V, 421E, 422N, 424L, 433I, 434D, 437Y, 453E
CDD
cd05151 (ChoK-like)

434D

active site
264I, 266G, 267M, 268T, 269N, 271N, 282V, 284R, 313S, 327S, 328E, 329Y, 330I, 332N, 333S, 334E, 417D, 419V, 421E, 422N, 424L, 433I, 434D, 437Y, 453E
CDD
cd05151 (ChoK-like)

437Y

active site
264I, 266G, 267M, 268T, 269N, 271N, 282V, 284R, 313S, 327S, 328E, 329Y, 330I, 332N, 333S, 334E, 417D, 419V, 421E, 422N, 424L, 433I, 434D, 437Y, 453E
CDD
cd05151 (ChoK-like)

453E

active site
264I, 266G, 267M, 268T, 269N, 271N, 282V, 284R, 313S, 327S, 328E, 329Y, 330I, 332N, 333S, 334E, 417D, 419V, 421E, 422N, 424L, 433I, 434D, 437Y, 453E
CDD
cd05151 (ChoK-like)
substrate binding ...

266G

substrate binding site
266G, 267M, 268T, 417D, 419V, 422N, 437Y, 453E
CDD
cd05151 (ChoK-like)

267M

substrate binding site
266G, 267M, 268T, 417D, 419V, 422N, 437Y, 453E
CDD
cd05151 (ChoK-like)

268T

substrate binding site
266G, 267M, 268T, 417D, 419V, 422N, 437Y, 453E
CDD
cd05151 (ChoK-like)

417D

substrate binding site
266G, 267M, 268T, 417D, 419V, 422N, 437Y, 453E
CDD
cd05151 (ChoK-like)

419V

substrate binding site
266G, 267M, 268T, 417D, 419V, 422N, 437Y, 453E
CDD
cd05151 (ChoK-like)

422N

substrate binding site
266G, 267M, 268T, 417D, 419V, 422N, 437Y, 453E
CDD
cd05151 (ChoK-like)

437Y

substrate binding site
266G, 267M, 268T, 417D, 419V, 422N, 437Y, 453E
CDD
cd05151 (ChoK-like)

453E

substrate binding site
266G, 267M, 268T, 417D, 419V, 422N, 437Y, 453E
CDD
cd05151 (ChoK-like)
dimer interface cd...

297Y

dimer interface
297Y, 300K, 301N, 304K, 305L, 315L, 316Y, 317F, 318F, 409I
CDD
cd05151 (ChoK-like)

300K

dimer interface
297Y, 300K, 301N, 304K, 305L, 315L, 316Y, 317F, 318F, 409I
CDD
cd05151 (ChoK-like)

301N

dimer interface
297Y, 300K, 301N, 304K, 305L, 315L, 316Y, 317F, 318F, 409I
CDD
cd05151 (ChoK-like)

304K

dimer interface
297Y, 300K, 301N, 304K, 305L, 315L, 316Y, 317F, 318F, 409I
CDD
cd05151 (ChoK-like)

305L

dimer interface
297Y, 300K, 301N, 304K, 305L, 315L, 316Y, 317F, 318F, 409I
CDD
cd05151 (ChoK-like)

315L

dimer interface
297Y, 300K, 301N, 304K, 305L, 315L, 316Y, 317F, 318F, 409I
CDD
cd05151 (ChoK-like)

316Y

dimer interface
297Y, 300K, 301N, 304K, 305L, 315L, 316Y, 317F, 318F, 409I
CDD
cd05151 (ChoK-like)

317F

dimer interface
297Y, 300K, 301N, 304K, 305L, 315L, 316Y, 317F, 318F, 409I
CDD
cd05151 (ChoK-like)

318F

dimer interface
297Y, 300K, 301N, 304K, 305L, 315L, 316Y, 317F, 318F, 409I
CDD
cd05151 (ChoK-like)

409I

dimer interface
297Y, 300K, 301N, 304K, 305L, 315L, 316Y, 317F, 318F, 409I
CDD
cd05151 (ChoK-like)

GO term prediction

Biological Process

GO:0009058 biosynthetic process

Molecular Function

GO:0016779 nucleotidyltransferase activity

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features

23726_FusoPortal_Gene_1129

Protein family membership

Homologous superfamilies

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component