23726_FusoPortal_Gene_1397

Protein

23726_FusoPortal_Gene_1397

Length

504 amino acids

Protein family membership

AICARFT/IMPCHase bienzyme (IPR002695)

Homologous superfamilies

Homologous superfamily
1 - 191
Methylglyoxal synthase-like domain superfamily (IPR036914)
203 - 504
Cytidine deaminase-like (IPR016193)
Homologous superfamily
205 - 354
AICAR transformylase, duplicated domain superfamily (IPR024051)
355 - 494
AICAR transformylase, duplicated domain superfamily (IPR024051)

1 50 100 150 200 250 300 350 400 450 504

Domains and repeats

Domain
14 - 128
Methylglyoxal synthase-like domain (IPR011607)

1 50 100 150 200 250 300 350 400 450 504

Detailed signature matches

IPR036914

Methylglyoxal synthase-like domain superfamily
1. G3DSA:3.40.50...
  
  1 - 191
  
  GENE3D
  G3DSA:3.40.50.1380 (G3DSA:3.40.50.1380)
2. SSF52335 (Methylgly...)
  
  2 - 191
  
  SUPERFAMILY
  SSF52335 (Methylglyoxal synthase-like)
IPR016193

Cytidine deaminase-like
1. SSF53927 (Cytidine ...)
  
  203 - 504
  
  SUPERFAMILY
  SSF53927 (Cytidine deaminase-like)
IPR024051

AICAR transformylase, duplicated domain superfamily
1. G3DSA:3.40.14...
  
  355 - 494
  
  GENE3D
  G3DSA:3.40.140.20 (G3DSA:3.40.140.20)
  
  205 - 354
  
  GENE3D
  G3DSA:3.40.140.20 (G3DSA:3.40.140.20)
IPR002695

AICARFT/IMPCHase bienzyme
1. PF01808 (AICARFT_IM...)
  
  133 - 436
  
  Pfam
  PF01808 (AICARFT_IMPCHas)
2. TIGR00355
  
  3 - 504
  
  TIGRFAMs
  TIGR00355 (TIGR00355)
3. PTHR11692 (BIFUNCTI...)
  
  3 - 504
  
  PANTHER
  PTHR11692 (BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN)
4. MF_00139 (PurH)
  
  2 - 504
  
  HAMAP
  MF_00139 (PurH)
5. PIRSF000414 (PurH)
  
  1 - 504
  
  PIRSF
  PIRSF000414 (PurH)
IPR011607

Methylglyoxal synthase-like domain
1. PF02142 (MGS)
  
  14 - 128
  
  Pfam
  PF02142 (MGS)

no IPR

Unintegrated signatures

cd01421 (IMPCH)

3 - 189

CDD
cd01421 (IMPCH)

Residue annotation

purine monophospha...

10Y

purine monophosphate binding site
10Y, 12K, 32T, 35T, 64K, 65T, 101N, 123D
CDD
cd01421 (IMPCH)

12K

purine monophosphate binding site
10Y, 12K, 32T, 35T, 64K, 65T, 101N, 123D
CDD
cd01421 (IMPCH)

32T

purine monophosphate binding site
10Y, 12K, 32T, 35T, 64K, 65T, 101N, 123D
CDD
cd01421 (IMPCH)

35T

purine monophosphate binding site
10Y, 12K, 32T, 35T, 64K, 65T, 101N, 123D
CDD
cd01421 (IMPCH)

64K

purine monophosphate binding site
10Y, 12K, 32T, 35T, 64K, 65T, 101N, 123D
CDD
cd01421 (IMPCH)

65T

purine monophosphate binding site
10Y, 12K, 32T, 35T, 64K, 65T, 101N, 123D
CDD
cd01421 (IMPCH)

101N

purine monophosphate binding site
10Y, 12K, 32T, 35T, 64K, 65T, 101N, 123D
CDD
cd01421 (IMPCH)

123D

purine monophosphate binding site
10Y, 12K, 32T, 35T, 64K, 65T, 101N, 123D
CDD
cd01421 (IMPCH)
dimer interface cd...

55F

dimer interface
55F, 58M, 59L, 62R, 63V, 66L, 67H, 68P, 71H, 72G, 75L, 122I, 123D, 124I, 127P, 131R, 132S, 135K, 168K, 171A, 172G, 173K, 181Y, 182D, 183A, 185I, 186S, 189L
CDD
cd01421 (IMPCH)

58M

dimer interface
55F, 58M, 59L, 62R, 63V, 66L, 67H, 68P, 71H, 72G, 75L, 122I, 123D, 124I, 127P, 131R, 132S, 135K, 168K, 171A, 172G, 173K, 181Y, 182D, 183A, 185I, 186S, 189L
CDD
cd01421 (IMPCH)

59L

dimer interface
55F, 58M, 59L, 62R, 63V, 66L, 67H, 68P, 71H, 72G, 75L, 122I, 123D, 124I, 127P, 131R, 132S, 135K, 168K, 171A, 172G, 173K, 181Y, 182D, 183A, 185I, 186S, 189L
CDD
cd01421 (IMPCH)

62R

dimer interface
55F, 58M, 59L, 62R, 63V, 66L, 67H, 68P, 71H, 72G, 75L, 122I, 123D, 124I, 127P, 131R, 132S, 135K, 168K, 171A, 172G, 173K, 181Y, 182D, 183A, 185I, 186S, 189L
CDD
cd01421 (IMPCH)

63V

dimer interface
55F, 58M, 59L, 62R, 63V, 66L, 67H, 68P, 71H, 72G, 75L, 122I, 123D, 124I, 127P, 131R, 132S, 135K, 168K, 171A, 172G, 173K, 181Y, 182D, 183A, 185I, 186S, 189L
CDD
cd01421 (IMPCH)

66L

dimer interface
55F, 58M, 59L, 62R, 63V, 66L, 67H, 68P, 71H, 72G, 75L, 122I, 123D, 124I, 127P, 131R, 132S, 135K, 168K, 171A, 172G, 173K, 181Y, 182D, 183A, 185I, 186S, 189L
CDD
cd01421 (IMPCH)

67H

dimer interface
55F, 58M, 59L, 62R, 63V, 66L, 67H, 68P, 71H, 72G, 75L, 122I, 123D, 124I, 127P, 131R, 132S, 135K, 168K, 171A, 172G, 173K, 181Y, 182D, 183A, 185I, 186S, 189L
CDD
cd01421 (IMPCH)

68P

dimer interface
55F, 58M, 59L, 62R, 63V, 66L, 67H, 68P, 71H, 72G, 75L, 122I, 123D, 124I, 127P, 131R, 132S, 135K, 168K, 171A, 172G, 173K, 181Y, 182D, 183A, 185I, 186S, 189L
CDD
cd01421 (IMPCH)

71H

dimer interface
55F, 58M, 59L, 62R, 63V, 66L, 67H, 68P, 71H, 72G, 75L, 122I, 123D, 124I, 127P, 131R, 132S, 135K, 168K, 171A, 172G, 173K, 181Y, 182D, 183A, 185I, 186S, 189L
CDD
cd01421 (IMPCH)

72G

dimer interface
55F, 58M, 59L, 62R, 63V, 66L, 67H, 68P, 71H, 72G, 75L, 122I, 123D, 124I, 127P, 131R, 132S, 135K, 168K, 171A, 172G, 173K, 181Y, 182D, 183A, 185I, 186S, 189L
CDD
cd01421 (IMPCH)

75L

dimer interface
55F, 58M, 59L, 62R, 63V, 66L, 67H, 68P, 71H, 72G, 75L, 122I, 123D, 124I, 127P, 131R, 132S, 135K, 168K, 171A, 172G, 173K, 181Y, 182D, 183A, 185I, 186S, 189L
CDD
cd01421 (IMPCH)

122I

dimer interface
55F, 58M, 59L, 62R, 63V, 66L, 67H, 68P, 71H, 72G, 75L, 122I, 123D, 124I, 127P, 131R, 132S, 135K, 168K, 171A, 172G, 173K, 181Y, 182D, 183A, 185I, 186S, 189L
CDD
cd01421 (IMPCH)

123D

dimer interface
55F, 58M, 59L, 62R, 63V, 66L, 67H, 68P, 71H, 72G, 75L, 122I, 123D, 124I, 127P, 131R, 132S, 135K, 168K, 171A, 172G, 173K, 181Y, 182D, 183A, 185I, 186S, 189L
CDD
cd01421 (IMPCH)

124I

dimer interface
55F, 58M, 59L, 62R, 63V, 66L, 67H, 68P, 71H, 72G, 75L, 122I, 123D, 124I, 127P, 131R, 132S, 135K, 168K, 171A, 172G, 173K, 181Y, 182D, 183A, 185I, 186S, 189L
CDD
cd01421 (IMPCH)

127P

dimer interface
55F, 58M, 59L, 62R, 63V, 66L, 67H, 68P, 71H, 72G, 75L, 122I, 123D, 124I, 127P, 131R, 132S, 135K, 168K, 171A, 172G, 173K, 181Y, 182D, 183A, 185I, 186S, 189L
CDD
cd01421 (IMPCH)

131R

dimer interface
55F, 58M, 59L, 62R, 63V, 66L, 67H, 68P, 71H, 72G, 75L, 122I, 123D, 124I, 127P, 131R, 132S, 135K, 168K, 171A, 172G, 173K, 181Y, 182D, 183A, 185I, 186S, 189L
CDD
cd01421 (IMPCH)

132S

dimer interface
55F, 58M, 59L, 62R, 63V, 66L, 67H, 68P, 71H, 72G, 75L, 122I, 123D, 124I, 127P, 131R, 132S, 135K, 168K, 171A, 172G, 173K, 181Y, 182D, 183A, 185I, 186S, 189L
CDD
cd01421 (IMPCH)

135K

dimer interface
55F, 58M, 59L, 62R, 63V, 66L, 67H, 68P, 71H, 72G, 75L, 122I, 123D, 124I, 127P, 131R, 132S, 135K, 168K, 171A, 172G, 173K, 181Y, 182D, 183A, 185I, 186S, 189L
CDD
cd01421 (IMPCH)

168K

dimer interface
55F, 58M, 59L, 62R, 63V, 66L, 67H, 68P, 71H, 72G, 75L, 122I, 123D, 124I, 127P, 131R, 132S, 135K, 168K, 171A, 172G, 173K, 181Y, 182D, 183A, 185I, 186S, 189L
CDD
cd01421 (IMPCH)

171A

dimer interface
55F, 58M, 59L, 62R, 63V, 66L, 67H, 68P, 71H, 72G, 75L, 122I, 123D, 124I, 127P, 131R, 132S, 135K, 168K, 171A, 172G, 173K, 181Y, 182D, 183A, 185I, 186S, 189L
CDD
cd01421 (IMPCH)

172G

dimer interface
55F, 58M, 59L, 62R, 63V, 66L, 67H, 68P, 71H, 72G, 75L, 122I, 123D, 124I, 127P, 131R, 132S, 135K, 168K, 171A, 172G, 173K, 181Y, 182D, 183A, 185I, 186S, 189L
CDD
cd01421 (IMPCH)

173K

dimer interface
55F, 58M, 59L, 62R, 63V, 66L, 67H, 68P, 71H, 72G, 75L, 122I, 123D, 124I, 127P, 131R, 132S, 135K, 168K, 171A, 172G, 173K, 181Y, 182D, 183A, 185I, 186S, 189L
CDD
cd01421 (IMPCH)

181Y

dimer interface
55F, 58M, 59L, 62R, 63V, 66L, 67H, 68P, 71H, 72G, 75L, 122I, 123D, 124I, 127P, 131R, 132S, 135K, 168K, 171A, 172G, 173K, 181Y, 182D, 183A, 185I, 186S, 189L
CDD
cd01421 (IMPCH)

182D

dimer interface
55F, 58M, 59L, 62R, 63V, 66L, 67H, 68P, 71H, 72G, 75L, 122I, 123D, 124I, 127P, 131R, 132S, 135K, 168K, 171A, 172G, 173K, 181Y, 182D, 183A, 185I, 186S, 189L
CDD
cd01421 (IMPCH)

183A

dimer interface
55F, 58M, 59L, 62R, 63V, 66L, 67H, 68P, 71H, 72G, 75L, 122I, 123D, 124I, 127P, 131R, 132S, 135K, 168K, 171A, 172G, 173K, 181Y, 182D, 183A, 185I, 186S, 189L
CDD
cd01421 (IMPCH)

185I

dimer interface
55F, 58M, 59L, 62R, 63V, 66L, 67H, 68P, 71H, 72G, 75L, 122I, 123D, 124I, 127P, 131R, 132S, 135K, 168K, 171A, 172G, 173K, 181Y, 182D, 183A, 185I, 186S, 189L
CDD
cd01421 (IMPCH)

186S

dimer interface
55F, 58M, 59L, 62R, 63V, 66L, 67H, 68P, 71H, 72G, 75L, 122I, 123D, 124I, 127P, 131R, 132S, 135K, 168K, 171A, 172G, 173K, 181Y, 182D, 183A, 185I, 186S, 189L
CDD
cd01421 (IMPCH)

189L

dimer interface
55F, 58M, 59L, 62R, 63V, 66L, 67H, 68P, 71H, 72G, 75L, 122I, 123D, 124I, 127P, 131R, 132S, 135K, 168K, 171A, 172G, 173K, 181Y, 182D, 183A, 185I, 186S, 189L
CDD
cd01421 (IMPCH)
putative catalytic...

64K

putative catalytic residues
64K, 123D
CDD
cd01421 (IMPCH)

123D

putative catalytic residues
64K, 123D
CDD
cd01421 (IMPCH)

GO term prediction

Biological Process

GO:0006164 purine nucleotide biosynthetic process

Molecular Function

GO:0003824 catalytic activity
GO:0003937 IMP cyclohydrolase activity
GO:0004643 phosphoribosylaminoimidazolecarboxamide formyltransferase activity

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features

23726_FusoPortal_Gene_1397

Protein family membership

Homologous superfamilies

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component