23726_FusoPortal_Gene_1422

Protein

23726_FusoPortal_Gene_1422

Length

257 amino acids

Protein family membership

None predicted.

Homologous superfamilies

Homologous superfamily
3 - 252
Tetrapyrrole methylase superfamily (IPR035996)
Homologous superfamily
6 - 125
Tetrapyrrole methylase, subdomain 1 (IPR014777)
126 - 257
Tetrapyrrole methylase, subdomain 2 (IPR014776)

1 50 100 150 200 257

Domains and repeats

Domain
7 - 252
Tetrapyrrole methylase (IPR000878)
Cobalamin (vitamin B12) biosynthesis CobM/CbiF, precorrin-4 C11-methyltransferase (IPR006362)

1 50 100 150 200 257

Detailed signature matches

IPR035996

Tetrapyrrole methylase superfamily
1. SSF53790 (Tetrapyrr...)
  
  3 - 252
  
  SUPERFAMILY
  SSF53790 (Tetrapyrrole methylase)
IPR014777

Tetrapyrrole methylase, subdomain 1
1. G3DSA:3.40.10...
  
  6 - 125
  
  GENE3D
  G3DSA:3.40.1010.10 (G3DSA:3.40.1010.10)
IPR014776

Tetrapyrrole methylase, subdomain 2
1. G3DSA:3.30.95...
  
  126 - 257
  
  GENE3D
  G3DSA:3.30.950.10 (G3DSA:3.30.950.10)
IPR000878

Tetrapyrrole methylase
1. PF00590 (TP_methylase)
  
  7 - 212
  
  Pfam
  PF00590 (TP_methylase)
IPR006362

Cobalamin (vitamin B12) biosynthesis CobM/CbiF, precorrin-4 C11-methyltransferase
1. cd11641 (Precorrin-...)
  
  8 - 234
  
  CDD
  cd11641 (Precorrin-4_C11-MT)
2. TIGR01465
  
  8 - 252
  
  TIGRFAMs
  TIGR01465 (TIGR01465)
IPR003043

Uroporphiryn-III C-methyltransferase, conserved site
1. PS00839 (SUMT_1)
  
  11 - 25
  
  PROSITE patterns
  PS00839 (SUMT_1)

no IPR

Unintegrated signatures

PTHR21091 (METHYLTE...)

1 - 255

PANTHER
PTHR21091 (METHYLTETRAHYDROFOLATE:HOMOCYSTEINE METHYLTRANSFERASE RELATED)
PTHR21091:SF17 (SUB...)

1 - 255

PANTHER
PTHR21091:SF17 (SUBFAMILY NOT NAMED)

Residue annotation

active site cd11641

15P

active site
15P, 86T, 87G, 88D, 91I, 92Y, 93G, 116S, 117S, 142R, 167I, 168F, 194V, 196R, 197A, 225A, 226Q
CDD
cd11641 (Precorrin-4_C11-MT)

86T

active site
15P, 86T, 87G, 88D, 91I, 92Y, 93G, 116S, 117S, 142R, 167I, 168F, 194V, 196R, 197A, 225A, 226Q
CDD
cd11641 (Precorrin-4_C11-MT)

87G

active site
15P, 86T, 87G, 88D, 91I, 92Y, 93G, 116S, 117S, 142R, 167I, 168F, 194V, 196R, 197A, 225A, 226Q
CDD
cd11641 (Precorrin-4_C11-MT)

88D

active site
15P, 86T, 87G, 88D, 91I, 92Y, 93G, 116S, 117S, 142R, 167I, 168F, 194V, 196R, 197A, 225A, 226Q
CDD
cd11641 (Precorrin-4_C11-MT)

91I

active site
15P, 86T, 87G, 88D, 91I, 92Y, 93G, 116S, 117S, 142R, 167I, 168F, 194V, 196R, 197A, 225A, 226Q
CDD
cd11641 (Precorrin-4_C11-MT)

92Y

active site
15P, 86T, 87G, 88D, 91I, 92Y, 93G, 116S, 117S, 142R, 167I, 168F, 194V, 196R, 197A, 225A, 226Q
CDD
cd11641 (Precorrin-4_C11-MT)

93G

active site
15P, 86T, 87G, 88D, 91I, 92Y, 93G, 116S, 117S, 142R, 167I, 168F, 194V, 196R, 197A, 225A, 226Q
CDD
cd11641 (Precorrin-4_C11-MT)

116S

active site
15P, 86T, 87G, 88D, 91I, 92Y, 93G, 116S, 117S, 142R, 167I, 168F, 194V, 196R, 197A, 225A, 226Q
CDD
cd11641 (Precorrin-4_C11-MT)

117S

active site
15P, 86T, 87G, 88D, 91I, 92Y, 93G, 116S, 117S, 142R, 167I, 168F, 194V, 196R, 197A, 225A, 226Q
CDD
cd11641 (Precorrin-4_C11-MT)

142R

active site
15P, 86T, 87G, 88D, 91I, 92Y, 93G, 116S, 117S, 142R, 167I, 168F, 194V, 196R, 197A, 225A, 226Q
CDD
cd11641 (Precorrin-4_C11-MT)

167I

active site
15P, 86T, 87G, 88D, 91I, 92Y, 93G, 116S, 117S, 142R, 167I, 168F, 194V, 196R, 197A, 225A, 226Q
CDD
cd11641 (Precorrin-4_C11-MT)

168F

active site
15P, 86T, 87G, 88D, 91I, 92Y, 93G, 116S, 117S, 142R, 167I, 168F, 194V, 196R, 197A, 225A, 226Q
CDD
cd11641 (Precorrin-4_C11-MT)

194V

active site
15P, 86T, 87G, 88D, 91I, 92Y, 93G, 116S, 117S, 142R, 167I, 168F, 194V, 196R, 197A, 225A, 226Q
CDD
cd11641 (Precorrin-4_C11-MT)

196R

active site
15P, 86T, 87G, 88D, 91I, 92Y, 93G, 116S, 117S, 142R, 167I, 168F, 194V, 196R, 197A, 225A, 226Q
CDD
cd11641 (Precorrin-4_C11-MT)

197A

active site
15P, 86T, 87G, 88D, 91I, 92Y, 93G, 116S, 117S, 142R, 167I, 168F, 194V, 196R, 197A, 225A, 226Q
CDD
cd11641 (Precorrin-4_C11-MT)

225A

active site
15P, 86T, 87G, 88D, 91I, 92Y, 93G, 116S, 117S, 142R, 167I, 168F, 194V, 196R, 197A, 225A, 226Q
CDD
cd11641 (Precorrin-4_C11-MT)

226Q

active site
15P, 86T, 87G, 88D, 91I, 92Y, 93G, 116S, 117S, 142R, 167I, 168F, 194V, 196R, 197A, 225A, 226Q
CDD
cd11641 (Precorrin-4_C11-MT)
SAM binding site c...

15P

SAM binding site
15P, 41L, 86T, 87G, 88D, 91I, 116S, 117S, 167I, 168F, 169L, 194V, 196R, 197A, 224T, 225A, 226Q
CDD
cd11641 (Precorrin-4_C11-MT)

41L

SAM binding site
15P, 41L, 86T, 87G, 88D, 91I, 116S, 117S, 167I, 168F, 169L, 194V, 196R, 197A, 224T, 225A, 226Q
CDD
cd11641 (Precorrin-4_C11-MT)

86T

SAM binding site
15P, 41L, 86T, 87G, 88D, 91I, 116S, 117S, 167I, 168F, 169L, 194V, 196R, 197A, 224T, 225A, 226Q
CDD
cd11641 (Precorrin-4_C11-MT)

87G

SAM binding site
15P, 41L, 86T, 87G, 88D, 91I, 116S, 117S, 167I, 168F, 169L, 194V, 196R, 197A, 224T, 225A, 226Q
CDD
cd11641 (Precorrin-4_C11-MT)

88D

SAM binding site
15P, 41L, 86T, 87G, 88D, 91I, 116S, 117S, 167I, 168F, 169L, 194V, 196R, 197A, 224T, 225A, 226Q
CDD
cd11641 (Precorrin-4_C11-MT)

91I

SAM binding site
15P, 41L, 86T, 87G, 88D, 91I, 116S, 117S, 167I, 168F, 169L, 194V, 196R, 197A, 224T, 225A, 226Q
CDD
cd11641 (Precorrin-4_C11-MT)

116S

SAM binding site
15P, 41L, 86T, 87G, 88D, 91I, 116S, 117S, 167I, 168F, 169L, 194V, 196R, 197A, 224T, 225A, 226Q
CDD
cd11641 (Precorrin-4_C11-MT)

117S

SAM binding site
15P, 41L, 86T, 87G, 88D, 91I, 116S, 117S, 167I, 168F, 169L, 194V, 196R, 197A, 224T, 225A, 226Q
CDD
cd11641 (Precorrin-4_C11-MT)

167I

SAM binding site
15P, 41L, 86T, 87G, 88D, 91I, 116S, 117S, 167I, 168F, 169L, 194V, 196R, 197A, 224T, 225A, 226Q
CDD
cd11641 (Precorrin-4_C11-MT)

168F

SAM binding site
15P, 41L, 86T, 87G, 88D, 91I, 116S, 117S, 167I, 168F, 169L, 194V, 196R, 197A, 224T, 225A, 226Q
CDD
cd11641 (Precorrin-4_C11-MT)

169L

SAM binding site
15P, 41L, 86T, 87G, 88D, 91I, 116S, 117S, 167I, 168F, 169L, 194V, 196R, 197A, 224T, 225A, 226Q
CDD
cd11641 (Precorrin-4_C11-MT)

194V

SAM binding site
15P, 41L, 86T, 87G, 88D, 91I, 116S, 117S, 167I, 168F, 169L, 194V, 196R, 197A, 224T, 225A, 226Q
CDD
cd11641 (Precorrin-4_C11-MT)

196R

SAM binding site
15P, 41L, 86T, 87G, 88D, 91I, 116S, 117S, 167I, 168F, 169L, 194V, 196R, 197A, 224T, 225A, 226Q
CDD
cd11641 (Precorrin-4_C11-MT)

197A

SAM binding site
15P, 41L, 86T, 87G, 88D, 91I, 116S, 117S, 167I, 168F, 169L, 194V, 196R, 197A, 224T, 225A, 226Q
CDD
cd11641 (Precorrin-4_C11-MT)

224T

SAM binding site
15P, 41L, 86T, 87G, 88D, 91I, 116S, 117S, 167I, 168F, 169L, 194V, 196R, 197A, 224T, 225A, 226Q
CDD
cd11641 (Precorrin-4_C11-MT)

225A

SAM binding site
15P, 41L, 86T, 87G, 88D, 91I, 116S, 117S, 167I, 168F, 169L, 194V, 196R, 197A, 224T, 225A, 226Q
CDD
cd11641 (Precorrin-4_C11-MT)

226Q

SAM binding site
15P, 41L, 86T, 87G, 88D, 91I, 116S, 117S, 167I, 168F, 169L, 194V, 196R, 197A, 224T, 225A, 226Q
CDD
cd11641 (Precorrin-4_C11-MT)
homodimer interfac...

17D

homodimer interface
17D, 19E, 20L, 21I, 22T, 23I, 24K, 26Q, 64L, 88D, 89P, 90A, 91I, 92Y, 93G, 94A, 95H, 96R, 97E, 99M, 100D, 103D, 111V, 113P, 114G, 115V, 116S, 118F, 119L, 122A, 123A, 126K, 128E, 129F, 130T, 134V, 135S, 136Q, 137T, 138V, 139I, 140C, 141T, 142R, 149V, 150P, 152K, 153E, 157S, 158L, 160K, 161H
CDD
cd11641 (Precorrin-4_C11-MT)

19E

homodimer interface
17D, 19E, 20L, 21I, 22T, 23I, 24K, 26Q, 64L, 88D, 89P, 90A, 91I, 92Y, 93G, 94A, 95H, 96R, 97E, 99M, 100D, 103D, 111V, 113P, 114G, 115V, 116S, 118F, 119L, 122A, 123A, 126K, 128E, 129F, 130T, 134V, 135S, 136Q, 137T, 138V, 139I, 140C, 141T, 142R, 149V, 150P, 152K, 153E, 157S, 158L, 160K, 161H
CDD
cd11641 (Precorrin-4_C11-MT)

20L

homodimer interface
17D, 19E, 20L, 21I, 22T, 23I, 24K, 26Q, 64L, 88D, 89P, 90A, 91I, 92Y, 93G, 94A, 95H, 96R, 97E, 99M, 100D, 103D, 111V, 113P, 114G, 115V, 116S, 118F, 119L, 122A, 123A, 126K, 128E, 129F, 130T, 134V, 135S, 136Q, 137T, 138V, 139I, 140C, 141T, 142R, 149V, 150P, 152K, 153E, 157S, 158L, 160K, 161H
CDD
cd11641 (Precorrin-4_C11-MT)

21I

homodimer interface
17D, 19E, 20L, 21I, 22T, 23I, 24K, 26Q, 64L, 88D, 89P, 90A, 91I, 92Y, 93G, 94A, 95H, 96R, 97E, 99M, 100D, 103D, 111V, 113P, 114G, 115V, 116S, 118F, 119L, 122A, 123A, 126K, 128E, 129F, 130T, 134V, 135S, 136Q, 137T, 138V, 139I, 140C, 141T, 142R, 149V, 150P, 152K, 153E, 157S, 158L, 160K, 161H
CDD
cd11641 (Precorrin-4_C11-MT)

22T

homodimer interface
17D, 19E, 20L, 21I, 22T, 23I, 24K, 26Q, 64L, 88D, 89P, 90A, 91I, 92Y, 93G, 94A, 95H, 96R, 97E, 99M, 100D, 103D, 111V, 113P, 114G, 115V, 116S, 118F, 119L, 122A, 123A, 126K, 128E, 129F, 130T, 134V, 135S, 136Q, 137T, 138V, 139I, 140C, 141T, 142R, 149V, 150P, 152K, 153E, 157S, 158L, 160K, 161H
CDD
cd11641 (Precorrin-4_C11-MT)

23I

homodimer interface
17D, 19E, 20L, 21I, 22T, 23I, 24K, 26Q, 64L, 88D, 89P, 90A, 91I, 92Y, 93G, 94A, 95H, 96R, 97E, 99M, 100D, 103D, 111V, 113P, 114G, 115V, 116S, 118F, 119L, 122A, 123A, 126K, 128E, 129F, 130T, 134V, 135S, 136Q, 137T, 138V, 139I, 140C, 141T, 142R, 149V, 150P, 152K, 153E, 157S, 158L, 160K, 161H
CDD
cd11641 (Precorrin-4_C11-MT)

24K

homodimer interface
17D, 19E, 20L, 21I, 22T, 23I, 24K, 26Q, 64L, 88D, 89P, 90A, 91I, 92Y, 93G, 94A, 95H, 96R, 97E, 99M, 100D, 103D, 111V, 113P, 114G, 115V, 116S, 118F, 119L, 122A, 123A, 126K, 128E, 129F, 130T, 134V, 135S, 136Q, 137T, 138V, 139I, 140C, 141T, 142R, 149V, 150P, 152K, 153E, 157S, 158L, 160K, 161H
CDD
cd11641 (Precorrin-4_C11-MT)

26Q

homodimer interface
17D, 19E, 20L, 21I, 22T, 23I, 24K, 26Q, 64L, 88D, 89P, 90A, 91I, 92Y, 93G, 94A, 95H, 96R, 97E, 99M, 100D, 103D, 111V, 113P, 114G, 115V, 116S, 118F, 119L, 122A, 123A, 126K, 128E, 129F, 130T, 134V, 135S, 136Q, 137T, 138V, 139I, 140C, 141T, 142R, 149V, 150P, 152K, 153E, 157S, 158L, 160K, 161H
CDD
cd11641 (Precorrin-4_C11-MT)

64L

homodimer interface
17D, 19E, 20L, 21I, 22T, 23I, 24K, 26Q, 64L, 88D, 89P, 90A, 91I, 92Y, 93G, 94A, 95H, 96R, 97E, 99M, 100D, 103D, 111V, 113P, 114G, 115V, 116S, 118F, 119L, 122A, 123A, 126K, 128E, 129F, 130T, 134V, 135S, 136Q, 137T, 138V, 139I, 140C, 141T, 142R, 149V, 150P, 152K, 153E, 157S, 158L, 160K, 161H
CDD
cd11641 (Precorrin-4_C11-MT)

88D

homodimer interface
17D, 19E, 20L, 21I, 22T, 23I, 24K, 26Q, 64L, 88D, 89P, 90A, 91I, 92Y, 93G, 94A, 95H, 96R, 97E, 99M, 100D, 103D, 111V, 113P, 114G, 115V, 116S, 118F, 119L, 122A, 123A, 126K, 128E, 129F, 130T, 134V, 135S, 136Q, 137T, 138V, 139I, 140C, 141T, 142R, 149V, 150P, 152K, 153E, 157S, 158L, 160K, 161H
CDD
cd11641 (Precorrin-4_C11-MT)

89P

homodimer interface
17D, 19E, 20L, 21I, 22T, 23I, 24K, 26Q, 64L, 88D, 89P, 90A, 91I, 92Y, 93G, 94A, 95H, 96R, 97E, 99M, 100D, 103D, 111V, 113P, 114G, 115V, 116S, 118F, 119L, 122A, 123A, 126K, 128E, 129F, 130T, 134V, 135S, 136Q, 137T, 138V, 139I, 140C, 141T, 142R, 149V, 150P, 152K, 153E, 157S, 158L, 160K, 161H
CDD
cd11641 (Precorrin-4_C11-MT)

90A

homodimer interface
17D, 19E, 20L, 21I, 22T, 23I, 24K, 26Q, 64L, 88D, 89P, 90A, 91I, 92Y, 93G, 94A, 95H, 96R, 97E, 99M, 100D, 103D, 111V, 113P, 114G, 115V, 116S, 118F, 119L, 122A, 123A, 126K, 128E, 129F, 130T, 134V, 135S, 136Q, 137T, 138V, 139I, 140C, 141T, 142R, 149V, 150P, 152K, 153E, 157S, 158L, 160K, 161H
CDD
cd11641 (Precorrin-4_C11-MT)

91I

homodimer interface
17D, 19E, 20L, 21I, 22T, 23I, 24K, 26Q, 64L, 88D, 89P, 90A, 91I, 92Y, 93G, 94A, 95H, 96R, 97E, 99M, 100D, 103D, 111V, 113P, 114G, 115V, 116S, 118F, 119L, 122A, 123A, 126K, 128E, 129F, 130T, 134V, 135S, 136Q, 137T, 138V, 139I, 140C, 141T, 142R, 149V, 150P, 152K, 153E, 157S, 158L, 160K, 161H
CDD
cd11641 (Precorrin-4_C11-MT)

92Y

homodimer interface
17D, 19E, 20L, 21I, 22T, 23I, 24K, 26Q, 64L, 88D, 89P, 90A, 91I, 92Y, 93G, 94A, 95H, 96R, 97E, 99M, 100D, 103D, 111V, 113P, 114G, 115V, 116S, 118F, 119L, 122A, 123A, 126K, 128E, 129F, 130T, 134V, 135S, 136Q, 137T, 138V, 139I, 140C, 141T, 142R, 149V, 150P, 152K, 153E, 157S, 158L, 160K, 161H
CDD
cd11641 (Precorrin-4_C11-MT)

93G

homodimer interface
17D, 19E, 20L, 21I, 22T, 23I, 24K, 26Q, 64L, 88D, 89P, 90A, 91I, 92Y, 93G, 94A, 95H, 96R, 97E, 99M, 100D, 103D, 111V, 113P, 114G, 115V, 116S, 118F, 119L, 122A, 123A, 126K, 128E, 129F, 130T, 134V, 135S, 136Q, 137T, 138V, 139I, 140C, 141T, 142R, 149V, 150P, 152K, 153E, 157S, 158L, 160K, 161H
CDD
cd11641 (Precorrin-4_C11-MT)

94A

homodimer interface
17D, 19E, 20L, 21I, 22T, 23I, 24K, 26Q, 64L, 88D, 89P, 90A, 91I, 92Y, 93G, 94A, 95H, 96R, 97E, 99M, 100D, 103D, 111V, 113P, 114G, 115V, 116S, 118F, 119L, 122A, 123A, 126K, 128E, 129F, 130T, 134V, 135S, 136Q, 137T, 138V, 139I, 140C, 141T, 142R, 149V, 150P, 152K, 153E, 157S, 158L, 160K, 161H
CDD
cd11641 (Precorrin-4_C11-MT)

95H

homodimer interface
17D, 19E, 20L, 21I, 22T, 23I, 24K, 26Q, 64L, 88D, 89P, 90A, 91I, 92Y, 93G, 94A, 95H, 96R, 97E, 99M, 100D, 103D, 111V, 113P, 114G, 115V, 116S, 118F, 119L, 122A, 123A, 126K, 128E, 129F, 130T, 134V, 135S, 136Q, 137T, 138V, 139I, 140C, 141T, 142R, 149V, 150P, 152K, 153E, 157S, 158L, 160K, 161H
CDD
cd11641 (Precorrin-4_C11-MT)

96R

homodimer interface
17D, 19E, 20L, 21I, 22T, 23I, 24K, 26Q, 64L, 88D, 89P, 90A, 91I, 92Y, 93G, 94A, 95H, 96R, 97E, 99M, 100D, 103D, 111V, 113P, 114G, 115V, 116S, 118F, 119L, 122A, 123A, 126K, 128E, 129F, 130T, 134V, 135S, 136Q, 137T, 138V, 139I, 140C, 141T, 142R, 149V, 150P, 152K, 153E, 157S, 158L, 160K, 161H
CDD
cd11641 (Precorrin-4_C11-MT)

97E

homodimer interface
17D, 19E, 20L, 21I, 22T, 23I, 24K, 26Q, 64L, 88D, 89P, 90A, 91I, 92Y, 93G, 94A, 95H, 96R, 97E, 99M, 100D, 103D, 111V, 113P, 114G, 115V, 116S, 118F, 119L, 122A, 123A, 126K, 128E, 129F, 130T, 134V, 135S, 136Q, 137T, 138V, 139I, 140C, 141T, 142R, 149V, 150P, 152K, 153E, 157S, 158L, 160K, 161H
CDD
cd11641 (Precorrin-4_C11-MT)

99M

homodimer interface
17D, 19E, 20L, 21I, 22T, 23I, 24K, 26Q, 64L, 88D, 89P, 90A, 91I, 92Y, 93G, 94A, 95H, 96R, 97E, 99M, 100D, 103D, 111V, 113P, 114G, 115V, 116S, 118F, 119L, 122A, 123A, 126K, 128E, 129F, 130T, 134V, 135S, 136Q, 137T, 138V, 139I, 140C, 141T, 142R, 149V, 150P, 152K, 153E, 157S, 158L, 160K, 161H
CDD
cd11641 (Precorrin-4_C11-MT)

100D

homodimer interface
17D, 19E, 20L, 21I, 22T, 23I, 24K, 26Q, 64L, 88D, 89P, 90A, 91I, 92Y, 93G, 94A, 95H, 96R, 97E, 99M, 100D, 103D, 111V, 113P, 114G, 115V, 116S, 118F, 119L, 122A, 123A, 126K, 128E, 129F, 130T, 134V, 135S, 136Q, 137T, 138V, 139I, 140C, 141T, 142R, 149V, 150P, 152K, 153E, 157S, 158L, 160K, 161H
CDD
cd11641 (Precorrin-4_C11-MT)

103D

homodimer interface
17D, 19E, 20L, 21I, 22T, 23I, 24K, 26Q, 64L, 88D, 89P, 90A, 91I, 92Y, 93G, 94A, 95H, 96R, 97E, 99M, 100D, 103D, 111V, 113P, 114G, 115V, 116S, 118F, 119L, 122A, 123A, 126K, 128E, 129F, 130T, 134V, 135S, 136Q, 137T, 138V, 139I, 140C, 141T, 142R, 149V, 150P, 152K, 153E, 157S, 158L, 160K, 161H
CDD
cd11641 (Precorrin-4_C11-MT)

111V

homodimer interface
17D, 19E, 20L, 21I, 22T, 23I, 24K, 26Q, 64L, 88D, 89P, 90A, 91I, 92Y, 93G, 94A, 95H, 96R, 97E, 99M, 100D, 103D, 111V, 113P, 114G, 115V, 116S, 118F, 119L, 122A, 123A, 126K, 128E, 129F, 130T, 134V, 135S, 136Q, 137T, 138V, 139I, 140C, 141T, 142R, 149V, 150P, 152K, 153E, 157S, 158L, 160K, 161H
CDD
cd11641 (Precorrin-4_C11-MT)

113P

homodimer interface
17D, 19E, 20L, 21I, 22T, 23I, 24K, 26Q, 64L, 88D, 89P, 90A, 91I, 92Y, 93G, 94A, 95H, 96R, 97E, 99M, 100D, 103D, 111V, 113P, 114G, 115V, 116S, 118F, 119L, 122A, 123A, 126K, 128E, 129F, 130T, 134V, 135S, 136Q, 137T, 138V, 139I, 140C, 141T, 142R, 149V, 150P, 152K, 153E, 157S, 158L, 160K, 161H
CDD
cd11641 (Precorrin-4_C11-MT)

114G

homodimer interface
17D, 19E, 20L, 21I, 22T, 23I, 24K, 26Q, 64L, 88D, 89P, 90A, 91I, 92Y, 93G, 94A, 95H, 96R, 97E, 99M, 100D, 103D, 111V, 113P, 114G, 115V, 116S, 118F, 119L, 122A, 123A, 126K, 128E, 129F, 130T, 134V, 135S, 136Q, 137T, 138V, 139I, 140C, 141T, 142R, 149V, 150P, 152K, 153E, 157S, 158L, 160K, 161H
CDD
cd11641 (Precorrin-4_C11-MT)

115V

homodimer interface
17D, 19E, 20L, 21I, 22T, 23I, 24K, 26Q, 64L, 88D, 89P, 90A, 91I, 92Y, 93G, 94A, 95H, 96R, 97E, 99M, 100D, 103D, 111V, 113P, 114G, 115V, 116S, 118F, 119L, 122A, 123A, 126K, 128E, 129F, 130T, 134V, 135S, 136Q, 137T, 138V, 139I, 140C, 141T, 142R, 149V, 150P, 152K, 153E, 157S, 158L, 160K, 161H
CDD
cd11641 (Precorrin-4_C11-MT)

116S

homodimer interface
17D, 19E, 20L, 21I, 22T, 23I, 24K, 26Q, 64L, 88D, 89P, 90A, 91I, 92Y, 93G, 94A, 95H, 96R, 97E, 99M, 100D, 103D, 111V, 113P, 114G, 115V, 116S, 118F, 119L, 122A, 123A, 126K, 128E, 129F, 130T, 134V, 135S, 136Q, 137T, 138V, 139I, 140C, 141T, 142R, 149V, 150P, 152K, 153E, 157S, 158L, 160K, 161H
CDD
cd11641 (Precorrin-4_C11-MT)

118F

homodimer interface
17D, 19E, 20L, 21I, 22T, 23I, 24K, 26Q, 64L, 88D, 89P, 90A, 91I, 92Y, 93G, 94A, 95H, 96R, 97E, 99M, 100D, 103D, 111V, 113P, 114G, 115V, 116S, 118F, 119L, 122A, 123A, 126K, 128E, 129F, 130T, 134V, 135S, 136Q, 137T, 138V, 139I, 140C, 141T, 142R, 149V, 150P, 152K, 153E, 157S, 158L, 160K, 161H
CDD
cd11641 (Precorrin-4_C11-MT)

119L

homodimer interface
17D, 19E, 20L, 21I, 22T, 23I, 24K, 26Q, 64L, 88D, 89P, 90A, 91I, 92Y, 93G, 94A, 95H, 96R, 97E, 99M, 100D, 103D, 111V, 113P, 114G, 115V, 116S, 118F, 119L, 122A, 123A, 126K, 128E, 129F, 130T, 134V, 135S, 136Q, 137T, 138V, 139I, 140C, 141T, 142R, 149V, 150P, 152K, 153E, 157S, 158L, 160K, 161H
CDD
cd11641 (Precorrin-4_C11-MT)

122A

homodimer interface
17D, 19E, 20L, 21I, 22T, 23I, 24K, 26Q, 64L, 88D, 89P, 90A, 91I, 92Y, 93G, 94A, 95H, 96R, 97E, 99M, 100D, 103D, 111V, 113P, 114G, 115V, 116S, 118F, 119L, 122A, 123A, 126K, 128E, 129F, 130T, 134V, 135S, 136Q, 137T, 138V, 139I, 140C, 141T, 142R, 149V, 150P, 152K, 153E, 157S, 158L, 160K, 161H
CDD
cd11641 (Precorrin-4_C11-MT)

123A

homodimer interface
17D, 19E, 20L, 21I, 22T, 23I, 24K, 26Q, 64L, 88D, 89P, 90A, 91I, 92Y, 93G, 94A, 95H, 96R, 97E, 99M, 100D, 103D, 111V, 113P, 114G, 115V, 116S, 118F, 119L, 122A, 123A, 126K, 128E, 129F, 130T, 134V, 135S, 136Q, 137T, 138V, 139I, 140C, 141T, 142R, 149V, 150P, 152K, 153E, 157S, 158L, 160K, 161H
CDD
cd11641 (Precorrin-4_C11-MT)

126K

homodimer interface
17D, 19E, 20L, 21I, 22T, 23I, 24K, 26Q, 64L, 88D, 89P, 90A, 91I, 92Y, 93G, 94A, 95H, 96R, 97E, 99M, 100D, 103D, 111V, 113P, 114G, 115V, 116S, 118F, 119L, 122A, 123A, 126K, 128E, 129F, 130T, 134V, 135S, 136Q, 137T, 138V, 139I, 140C, 141T, 142R, 149V, 150P, 152K, 153E, 157S, 158L, 160K, 161H
CDD
cd11641 (Precorrin-4_C11-MT)

128E

homodimer interface
17D, 19E, 20L, 21I, 22T, 23I, 24K, 26Q, 64L, 88D, 89P, 90A, 91I, 92Y, 93G, 94A, 95H, 96R, 97E, 99M, 100D, 103D, 111V, 113P, 114G, 115V, 116S, 118F, 119L, 122A, 123A, 126K, 128E, 129F, 130T, 134V, 135S, 136Q, 137T, 138V, 139I, 140C, 141T, 142R, 149V, 150P, 152K, 153E, 157S, 158L, 160K, 161H
CDD
cd11641 (Precorrin-4_C11-MT)

129F

homodimer interface
17D, 19E, 20L, 21I, 22T, 23I, 24K, 26Q, 64L, 88D, 89P, 90A, 91I, 92Y, 93G, 94A, 95H, 96R, 97E, 99M, 100D, 103D, 111V, 113P, 114G, 115V, 116S, 118F, 119L, 122A, 123A, 126K, 128E, 129F, 130T, 134V, 135S, 136Q, 137T, 138V, 139I, 140C, 141T, 142R, 149V, 150P, 152K, 153E, 157S, 158L, 160K, 161H
CDD
cd11641 (Precorrin-4_C11-MT)

130T

homodimer interface
17D, 19E, 20L, 21I, 22T, 23I, 24K, 26Q, 64L, 88D, 89P, 90A, 91I, 92Y, 93G, 94A, 95H, 96R, 97E, 99M, 100D, 103D, 111V, 113P, 114G, 115V, 116S, 118F, 119L, 122A, 123A, 126K, 128E, 129F, 130T, 134V, 135S, 136Q, 137T, 138V, 139I, 140C, 141T, 142R, 149V, 150P, 152K, 153E, 157S, 158L, 160K, 161H
CDD
cd11641 (Precorrin-4_C11-MT)

134V

homodimer interface
17D, 19E, 20L, 21I, 22T, 23I, 24K, 26Q, 64L, 88D, 89P, 90A, 91I, 92Y, 93G, 94A, 95H, 96R, 97E, 99M, 100D, 103D, 111V, 113P, 114G, 115V, 116S, 118F, 119L, 122A, 123A, 126K, 128E, 129F, 130T, 134V, 135S, 136Q, 137T, 138V, 139I, 140C, 141T, 142R, 149V, 150P, 152K, 153E, 157S, 158L, 160K, 161H
CDD
cd11641 (Precorrin-4_C11-MT)

135S

homodimer interface
17D, 19E, 20L, 21I, 22T, 23I, 24K, 26Q, 64L, 88D, 89P, 90A, 91I, 92Y, 93G, 94A, 95H, 96R, 97E, 99M, 100D, 103D, 111V, 113P, 114G, 115V, 116S, 118F, 119L, 122A, 123A, 126K, 128E, 129F, 130T, 134V, 135S, 136Q, 137T, 138V, 139I, 140C, 141T, 142R, 149V, 150P, 152K, 153E, 157S, 158L, 160K, 161H
CDD
cd11641 (Precorrin-4_C11-MT)

136Q

homodimer interface
17D, 19E, 20L, 21I, 22T, 23I, 24K, 26Q, 64L, 88D, 89P, 90A, 91I, 92Y, 93G, 94A, 95H, 96R, 97E, 99M, 100D, 103D, 111V, 113P, 114G, 115V, 116S, 118F, 119L, 122A, 123A, 126K, 128E, 129F, 130T, 134V, 135S, 136Q, 137T, 138V, 139I, 140C, 141T, 142R, 149V, 150P, 152K, 153E, 157S, 158L, 160K, 161H
CDD
cd11641 (Precorrin-4_C11-MT)

137T

homodimer interface
17D, 19E, 20L, 21I, 22T, 23I, 24K, 26Q, 64L, 88D, 89P, 90A, 91I, 92Y, 93G, 94A, 95H, 96R, 97E, 99M, 100D, 103D, 111V, 113P, 114G, 115V, 116S, 118F, 119L, 122A, 123A, 126K, 128E, 129F, 130T, 134V, 135S, 136Q, 137T, 138V, 139I, 140C, 141T, 142R, 149V, 150P, 152K, 153E, 157S, 158L, 160K, 161H
CDD
cd11641 (Precorrin-4_C11-MT)

138V

homodimer interface
17D, 19E, 20L, 21I, 22T, 23I, 24K, 26Q, 64L, 88D, 89P, 90A, 91I, 92Y, 93G, 94A, 95H, 96R, 97E, 99M, 100D, 103D, 111V, 113P, 114G, 115V, 116S, 118F, 119L, 122A, 123A, 126K, 128E, 129F, 130T, 134V, 135S, 136Q, 137T, 138V, 139I, 140C, 141T, 142R, 149V, 150P, 152K, 153E, 157S, 158L, 160K, 161H
CDD
cd11641 (Precorrin-4_C11-MT)

139I

homodimer interface
17D, 19E, 20L, 21I, 22T, 23I, 24K, 26Q, 64L, 88D, 89P, 90A, 91I, 92Y, 93G, 94A, 95H, 96R, 97E, 99M, 100D, 103D, 111V, 113P, 114G, 115V, 116S, 118F, 119L, 122A, 123A, 126K, 128E, 129F, 130T, 134V, 135S, 136Q, 137T, 138V, 139I, 140C, 141T, 142R, 149V, 150P, 152K, 153E, 157S, 158L, 160K, 161H
CDD
cd11641 (Precorrin-4_C11-MT)

140C

homodimer interface
17D, 19E, 20L, 21I, 22T, 23I, 24K, 26Q, 64L, 88D, 89P, 90A, 91I, 92Y, 93G, 94A, 95H, 96R, 97E, 99M, 100D, 103D, 111V, 113P, 114G, 115V, 116S, 118F, 119L, 122A, 123A, 126K, 128E, 129F, 130T, 134V, 135S, 136Q, 137T, 138V, 139I, 140C, 141T, 142R, 149V, 150P, 152K, 153E, 157S, 158L, 160K, 161H
CDD
cd11641 (Precorrin-4_C11-MT)

141T

homodimer interface
17D, 19E, 20L, 21I, 22T, 23I, 24K, 26Q, 64L, 88D, 89P, 90A, 91I, 92Y, 93G, 94A, 95H, 96R, 97E, 99M, 100D, 103D, 111V, 113P, 114G, 115V, 116S, 118F, 119L, 122A, 123A, 126K, 128E, 129F, 130T, 134V, 135S, 136Q, 137T, 138V, 139I, 140C, 141T, 142R, 149V, 150P, 152K, 153E, 157S, 158L, 160K, 161H
CDD
cd11641 (Precorrin-4_C11-MT)

142R

homodimer interface
17D, 19E, 20L, 21I, 22T, 23I, 24K, 26Q, 64L, 88D, 89P, 90A, 91I, 92Y, 93G, 94A, 95H, 96R, 97E, 99M, 100D, 103D, 111V, 113P, 114G, 115V, 116S, 118F, 119L, 122A, 123A, 126K, 128E, 129F, 130T, 134V, 135S, 136Q, 137T, 138V, 139I, 140C, 141T, 142R, 149V, 150P, 152K, 153E, 157S, 158L, 160K, 161H
CDD
cd11641 (Precorrin-4_C11-MT)

149V

homodimer interface
17D, 19E, 20L, 21I, 22T, 23I, 24K, 26Q, 64L, 88D, 89P, 90A, 91I, 92Y, 93G, 94A, 95H, 96R, 97E, 99M, 100D, 103D, 111V, 113P, 114G, 115V, 116S, 118F, 119L, 122A, 123A, 126K, 128E, 129F, 130T, 134V, 135S, 136Q, 137T, 138V, 139I, 140C, 141T, 142R, 149V, 150P, 152K, 153E, 157S, 158L, 160K, 161H
CDD
cd11641 (Precorrin-4_C11-MT)

150P

homodimer interface
17D, 19E, 20L, 21I, 22T, 23I, 24K, 26Q, 64L, 88D, 89P, 90A, 91I, 92Y, 93G, 94A, 95H, 96R, 97E, 99M, 100D, 103D, 111V, 113P, 114G, 115V, 116S, 118F, 119L, 122A, 123A, 126K, 128E, 129F, 130T, 134V, 135S, 136Q, 137T, 138V, 139I, 140C, 141T, 142R, 149V, 150P, 152K, 153E, 157S, 158L, 160K, 161H
CDD
cd11641 (Precorrin-4_C11-MT)

152K

homodimer interface
17D, 19E, 20L, 21I, 22T, 23I, 24K, 26Q, 64L, 88D, 89P, 90A, 91I, 92Y, 93G, 94A, 95H, 96R, 97E, 99M, 100D, 103D, 111V, 113P, 114G, 115V, 116S, 118F, 119L, 122A, 123A, 126K, 128E, 129F, 130T, 134V, 135S, 136Q, 137T, 138V, 139I, 140C, 141T, 142R, 149V, 150P, 152K, 153E, 157S, 158L, 160K, 161H
CDD
cd11641 (Precorrin-4_C11-MT)

153E

homodimer interface
17D, 19E, 20L, 21I, 22T, 23I, 24K, 26Q, 64L, 88D, 89P, 90A, 91I, 92Y, 93G, 94A, 95H, 96R, 97E, 99M, 100D, 103D, 111V, 113P, 114G, 115V, 116S, 118F, 119L, 122A, 123A, 126K, 128E, 129F, 130T, 134V, 135S, 136Q, 137T, 138V, 139I, 140C, 141T, 142R, 149V, 150P, 152K, 153E, 157S, 158L, 160K, 161H
CDD
cd11641 (Precorrin-4_C11-MT)

157S

homodimer interface
17D, 19E, 20L, 21I, 22T, 23I, 24K, 26Q, 64L, 88D, 89P, 90A, 91I, 92Y, 93G, 94A, 95H, 96R, 97E, 99M, 100D, 103D, 111V, 113P, 114G, 115V, 116S, 118F, 119L, 122A, 123A, 126K, 128E, 129F, 130T, 134V, 135S, 136Q, 137T, 138V, 139I, 140C, 141T, 142R, 149V, 150P, 152K, 153E, 157S, 158L, 160K, 161H
CDD
cd11641 (Precorrin-4_C11-MT)

158L

homodimer interface
17D, 19E, 20L, 21I, 22T, 23I, 24K, 26Q, 64L, 88D, 89P, 90A, 91I, 92Y, 93G, 94A, 95H, 96R, 97E, 99M, 100D, 103D, 111V, 113P, 114G, 115V, 116S, 118F, 119L, 122A, 123A, 126K, 128E, 129F, 130T, 134V, 135S, 136Q, 137T, 138V, 139I, 140C, 141T, 142R, 149V, 150P, 152K, 153E, 157S, 158L, 160K, 161H
CDD
cd11641 (Precorrin-4_C11-MT)

160K

homodimer interface
17D, 19E, 20L, 21I, 22T, 23I, 24K, 26Q, 64L, 88D, 89P, 90A, 91I, 92Y, 93G, 94A, 95H, 96R, 97E, 99M, 100D, 103D, 111V, 113P, 114G, 115V, 116S, 118F, 119L, 122A, 123A, 126K, 128E, 129F, 130T, 134V, 135S, 136Q, 137T, 138V, 139I, 140C, 141T, 142R, 149V, 150P, 152K, 153E, 157S, 158L, 160K, 161H
CDD
cd11641 (Precorrin-4_C11-MT)

161H

homodimer interface
17D, 19E, 20L, 21I, 22T, 23I, 24K, 26Q, 64L, 88D, 89P, 90A, 91I, 92Y, 93G, 94A, 95H, 96R, 97E, 99M, 100D, 103D, 111V, 113P, 114G, 115V, 116S, 118F, 119L, 122A, 123A, 126K, 128E, 129F, 130T, 134V, 135S, 136Q, 137T, 138V, 139I, 140C, 141T, 142R, 149V, 150P, 152K, 153E, 157S, 158L, 160K, 161H
CDD
cd11641 (Precorrin-4_C11-MT)

GO term prediction

Biological Process

GO:0008152 metabolic process
GO:0009236 cobalamin biosynthetic process
GO:0055114 oxidation-reduction process

Molecular Function

GO:0008168 methyltransferase activity
GO:0046026 precorrin-4 C11-methyltransferase activity

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features

23726_FusoPortal_Gene_1422

Protein family membership

Homologous superfamilies

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component