23726_FusoPortal_Gene_1751

Protein

23726_FusoPortal_Gene_1751

Length

485 amino acids

Protein family membership

Sirohaem synthase (IPR012409)

Homologous superfamilies

Homologous superfamily
2 - 249
Tetrapyrrole methylase superfamily (IPR035996)
252 - 484
Tetrapyrrole biosynthesis, uroporphyrinogen III synthase superfamily (IPR036108)
Homologous superfamily
3 - 128
Tetrapyrrole methylase, subdomain 1 (IPR014777)
129 - 259
Tetrapyrrole methylase, subdomain 2 (IPR014776)

1 50 100 150 200 250 300 350 400 450 485

Domains and repeats

Domain
4 - 239
Tetrapyrrole methylase (IPR000878)
Uroporphyrin-III C-methyltransferase (IPR006366)
254 - 483
Tetrapyrrole biosynthesis, uroporphyrinogen III synthase (IPR003754)

1 50 100 150 200 250 300 350 400 450 485

Detailed signature matches

IPR035996

Tetrapyrrole methylase superfamily
1. SSF53790 (Tetrapyrr...)
  
  2 - 249
  
  SUPERFAMILY
  SSF53790 (Tetrapyrrole methylase)
IPR014777

Tetrapyrrole methylase, subdomain 1
1. G3DSA:3.40.10...
  
  3 - 128
  
  GENE3D
  G3DSA:3.40.1010.10 (G3DSA:3.40.1010.10)
IPR014776

Tetrapyrrole methylase, subdomain 2
1. G3DSA:3.30.95...
  
  129 - 259
  
  GENE3D
  G3DSA:3.30.950.10 (G3DSA:3.30.950.10)
IPR036108

Tetrapyrrole biosynthesis, uroporphyrinogen III synthase superfamily
1. SSF69618 (HemD-like)
  
  252 - 484
  
  SUPERFAMILY
  SSF69618 (HemD-like)
IPR012409

Sirohaem synthase
1. PIRSF036426 (Siroha...)
  
  1 - 255
  
  PIRSF
  PIRSF036426 (Sirohaem_synth)
IPR000878

Tetrapyrrole methylase
1. PF00590 (TP_methylase)
  
  7 - 214
  
  Pfam
  PF00590 (TP_methylase)
IPR006366

Uroporphyrin-III C-methyltransferase
1. TIGR01469
  
  4 - 239
  
  TIGRFAMs
  TIGR01469 (TIGR01469)
IPR003754

Tetrapyrrole biosynthesis, uroporphyrinogen III synthase
1. cd06578 (HemD)
  
  254 - 483
  
  CDD
  cd06578 (HemD)
2. PF02602 (HEM4)
  
  265 - 480
  
  Pfam
  PF02602 (HEM4)

no IPR

Unintegrated signatures

G3DSA:3.40.50...

260 - 371

GENE3D
G3DSA:3.40.50.10090 (G3DSA:3.40.50.10090)

392 - 485

GENE3D
G3DSA:3.40.50.10090 (G3DSA:3.40.50.10090)
PTHR21091 (METHYLTE...)

2 - 253

PANTHER
PTHR21091 (METHYLTETRAHYDROFOLATE:HOMOCYSTEINE METHYLTRANSFERASE RELATED)
PTHR21091:SF16 (SIR...)

2 - 253

PANTHER
PTHR21091:SF16 (SIROHEME SYNTHASE)
cd11642 (SUMT)

5 - 237

CDD
cd11642 (SUMT)

Residue annotation

active site cd11642

13P

active site
13P, 36D, 37R, 38L, 89G, 90G, 91D, 94V, 95F, 96G, 97R, 119T, 120S, 124V, 145T, 147H, 169F, 170L, 171M, 172G, 173V, 197I, 199K, 200G, 202T, 226P, 227P, 228A, 229I
CDD
cd11642 (SUMT)

36D

active site
13P, 36D, 37R, 38L, 89G, 90G, 91D, 94V, 95F, 96G, 97R, 119T, 120S, 124V, 145T, 147H, 169F, 170L, 171M, 172G, 173V, 197I, 199K, 200G, 202T, 226P, 227P, 228A, 229I
CDD
cd11642 (SUMT)

37R

active site
13P, 36D, 37R, 38L, 89G, 90G, 91D, 94V, 95F, 96G, 97R, 119T, 120S, 124V, 145T, 147H, 169F, 170L, 171M, 172G, 173V, 197I, 199K, 200G, 202T, 226P, 227P, 228A, 229I
CDD
cd11642 (SUMT)

38L

active site
13P, 36D, 37R, 38L, 89G, 90G, 91D, 94V, 95F, 96G, 97R, 119T, 120S, 124V, 145T, 147H, 169F, 170L, 171M, 172G, 173V, 197I, 199K, 200G, 202T, 226P, 227P, 228A, 229I
CDD
cd11642 (SUMT)

89G

active site
13P, 36D, 37R, 38L, 89G, 90G, 91D, 94V, 95F, 96G, 97R, 119T, 120S, 124V, 145T, 147H, 169F, 170L, 171M, 172G, 173V, 197I, 199K, 200G, 202T, 226P, 227P, 228A, 229I
CDD
cd11642 (SUMT)

90G

active site
13P, 36D, 37R, 38L, 89G, 90G, 91D, 94V, 95F, 96G, 97R, 119T, 120S, 124V, 145T, 147H, 169F, 170L, 171M, 172G, 173V, 197I, 199K, 200G, 202T, 226P, 227P, 228A, 229I
CDD
cd11642 (SUMT)

91D

active site
13P, 36D, 37R, 38L, 89G, 90G, 91D, 94V, 95F, 96G, 97R, 119T, 120S, 124V, 145T, 147H, 169F, 170L, 171M, 172G, 173V, 197I, 199K, 200G, 202T, 226P, 227P, 228A, 229I
CDD
cd11642 (SUMT)

94V

active site
13P, 36D, 37R, 38L, 89G, 90G, 91D, 94V, 95F, 96G, 97R, 119T, 120S, 124V, 145T, 147H, 169F, 170L, 171M, 172G, 173V, 197I, 199K, 200G, 202T, 226P, 227P, 228A, 229I
CDD
cd11642 (SUMT)

95F

active site
13P, 36D, 37R, 38L, 89G, 90G, 91D, 94V, 95F, 96G, 97R, 119T, 120S, 124V, 145T, 147H, 169F, 170L, 171M, 172G, 173V, 197I, 199K, 200G, 202T, 226P, 227P, 228A, 229I
CDD
cd11642 (SUMT)

96G

active site
13P, 36D, 37R, 38L, 89G, 90G, 91D, 94V, 95F, 96G, 97R, 119T, 120S, 124V, 145T, 147H, 169F, 170L, 171M, 172G, 173V, 197I, 199K, 200G, 202T, 226P, 227P, 228A, 229I
CDD
cd11642 (SUMT)

97R

active site
13P, 36D, 37R, 38L, 89G, 90G, 91D, 94V, 95F, 96G, 97R, 119T, 120S, 124V, 145T, 147H, 169F, 170L, 171M, 172G, 173V, 197I, 199K, 200G, 202T, 226P, 227P, 228A, 229I
CDD
cd11642 (SUMT)

119T

active site
13P, 36D, 37R, 38L, 89G, 90G, 91D, 94V, 95F, 96G, 97R, 119T, 120S, 124V, 145T, 147H, 169F, 170L, 171M, 172G, 173V, 197I, 199K, 200G, 202T, 226P, 227P, 228A, 229I
CDD
cd11642 (SUMT)

120S

active site
13P, 36D, 37R, 38L, 89G, 90G, 91D, 94V, 95F, 96G, 97R, 119T, 120S, 124V, 145T, 147H, 169F, 170L, 171M, 172G, 173V, 197I, 199K, 200G, 202T, 226P, 227P, 228A, 229I
CDD
cd11642 (SUMT)

124V

active site
13P, 36D, 37R, 38L, 89G, 90G, 91D, 94V, 95F, 96G, 97R, 119T, 120S, 124V, 145T, 147H, 169F, 170L, 171M, 172G, 173V, 197I, 199K, 200G, 202T, 226P, 227P, 228A, 229I
CDD
cd11642 (SUMT)

145T

active site
13P, 36D, 37R, 38L, 89G, 90G, 91D, 94V, 95F, 96G, 97R, 119T, 120S, 124V, 145T, 147H, 169F, 170L, 171M, 172G, 173V, 197I, 199K, 200G, 202T, 226P, 227P, 228A, 229I
CDD
cd11642 (SUMT)

147H

active site
13P, 36D, 37R, 38L, 89G, 90G, 91D, 94V, 95F, 96G, 97R, 119T, 120S, 124V, 145T, 147H, 169F, 170L, 171M, 172G, 173V, 197I, 199K, 200G, 202T, 226P, 227P, 228A, 229I
CDD
cd11642 (SUMT)

169F

active site
13P, 36D, 37R, 38L, 89G, 90G, 91D, 94V, 95F, 96G, 97R, 119T, 120S, 124V, 145T, 147H, 169F, 170L, 171M, 172G, 173V, 197I, 199K, 200G, 202T, 226P, 227P, 228A, 229I
CDD
cd11642 (SUMT)

170L

active site
13P, 36D, 37R, 38L, 89G, 90G, 91D, 94V, 95F, 96G, 97R, 119T, 120S, 124V, 145T, 147H, 169F, 170L, 171M, 172G, 173V, 197I, 199K, 200G, 202T, 226P, 227P, 228A, 229I
CDD
cd11642 (SUMT)

171M

active site
13P, 36D, 37R, 38L, 89G, 90G, 91D, 94V, 95F, 96G, 97R, 119T, 120S, 124V, 145T, 147H, 169F, 170L, 171M, 172G, 173V, 197I, 199K, 200G, 202T, 226P, 227P, 228A, 229I
CDD
cd11642 (SUMT)

172G

active site
13P, 36D, 37R, 38L, 89G, 90G, 91D, 94V, 95F, 96G, 97R, 119T, 120S, 124V, 145T, 147H, 169F, 170L, 171M, 172G, 173V, 197I, 199K, 200G, 202T, 226P, 227P, 228A, 229I
CDD
cd11642 (SUMT)

173V

active site
13P, 36D, 37R, 38L, 89G, 90G, 91D, 94V, 95F, 96G, 97R, 119T, 120S, 124V, 145T, 147H, 169F, 170L, 171M, 172G, 173V, 197I, 199K, 200G, 202T, 226P, 227P, 228A, 229I
CDD
cd11642 (SUMT)

197I

active site
13P, 36D, 37R, 38L, 89G, 90G, 91D, 94V, 95F, 96G, 97R, 119T, 120S, 124V, 145T, 147H, 169F, 170L, 171M, 172G, 173V, 197I, 199K, 200G, 202T, 226P, 227P, 228A, 229I
CDD
cd11642 (SUMT)

199K

active site
13P, 36D, 37R, 38L, 89G, 90G, 91D, 94V, 95F, 96G, 97R, 119T, 120S, 124V, 145T, 147H, 169F, 170L, 171M, 172G, 173V, 197I, 199K, 200G, 202T, 226P, 227P, 228A, 229I
CDD
cd11642 (SUMT)

200G

active site
13P, 36D, 37R, 38L, 89G, 90G, 91D, 94V, 95F, 96G, 97R, 119T, 120S, 124V, 145T, 147H, 169F, 170L, 171M, 172G, 173V, 197I, 199K, 200G, 202T, 226P, 227P, 228A, 229I
CDD
cd11642 (SUMT)

202T

active site
13P, 36D, 37R, 38L, 89G, 90G, 91D, 94V, 95F, 96G, 97R, 119T, 120S, 124V, 145T, 147H, 169F, 170L, 171M, 172G, 173V, 197I, 199K, 200G, 202T, 226P, 227P, 228A, 229I
CDD
cd11642 (SUMT)

226P

active site
13P, 36D, 37R, 38L, 89G, 90G, 91D, 94V, 95F, 96G, 97R, 119T, 120S, 124V, 145T, 147H, 169F, 170L, 171M, 172G, 173V, 197I, 199K, 200G, 202T, 226P, 227P, 228A, 229I
CDD
cd11642 (SUMT)

227P

active site
13P, 36D, 37R, 38L, 89G, 90G, 91D, 94V, 95F, 96G, 97R, 119T, 120S, 124V, 145T, 147H, 169F, 170L, 171M, 172G, 173V, 197I, 199K, 200G, 202T, 226P, 227P, 228A, 229I
CDD
cd11642 (SUMT)

228A

active site
13P, 36D, 37R, 38L, 89G, 90G, 91D, 94V, 95F, 96G, 97R, 119T, 120S, 124V, 145T, 147H, 169F, 170L, 171M, 172G, 173V, 197I, 199K, 200G, 202T, 226P, 227P, 228A, 229I
CDD
cd11642 (SUMT)

229I

active site
13P, 36D, 37R, 38L, 89G, 90G, 91D, 94V, 95F, 96G, 97R, 119T, 120S, 124V, 145T, 147H, 169F, 170L, 171M, 172G, 173V, 197I, 199K, 200G, 202T, 226P, 227P, 228A, 229I
CDD
cd11642 (SUMT)
SAM binding site c...

13P

SAM binding site
13P, 89G, 90G, 91D, 94V, 95F, 119T, 120S, 170L, 197I, 199K, 200G, 227P, 228A, 229I
CDD
cd11642 (SUMT)

89G

SAM binding site
13P, 89G, 90G, 91D, 94V, 95F, 119T, 120S, 170L, 197I, 199K, 200G, 227P, 228A, 229I
CDD
cd11642 (SUMT)

90G

SAM binding site
13P, 89G, 90G, 91D, 94V, 95F, 119T, 120S, 170L, 197I, 199K, 200G, 227P, 228A, 229I
CDD
cd11642 (SUMT)

91D

SAM binding site
13P, 89G, 90G, 91D, 94V, 95F, 119T, 120S, 170L, 197I, 199K, 200G, 227P, 228A, 229I
CDD
cd11642 (SUMT)

94V

SAM binding site
13P, 89G, 90G, 91D, 94V, 95F, 119T, 120S, 170L, 197I, 199K, 200G, 227P, 228A, 229I
CDD
cd11642 (SUMT)

95F

SAM binding site
13P, 89G, 90G, 91D, 94V, 95F, 119T, 120S, 170L, 197I, 199K, 200G, 227P, 228A, 229I
CDD
cd11642 (SUMT)

119T

SAM binding site
13P, 89G, 90G, 91D, 94V, 95F, 119T, 120S, 170L, 197I, 199K, 200G, 227P, 228A, 229I
CDD
cd11642 (SUMT)

120S

SAM binding site
13P, 89G, 90G, 91D, 94V, 95F, 119T, 120S, 170L, 197I, 199K, 200G, 227P, 228A, 229I
CDD
cd11642 (SUMT)

170L

SAM binding site
13P, 89G, 90G, 91D, 94V, 95F, 119T, 120S, 170L, 197I, 199K, 200G, 227P, 228A, 229I
CDD
cd11642 (SUMT)

197I

SAM binding site
13P, 89G, 90G, 91D, 94V, 95F, 119T, 120S, 170L, 197I, 199K, 200G, 227P, 228A, 229I
CDD
cd11642 (SUMT)

199K

SAM binding site
13P, 89G, 90G, 91D, 94V, 95F, 119T, 120S, 170L, 197I, 199K, 200G, 227P, 228A, 229I
CDD
cd11642 (SUMT)

200G

SAM binding site
13P, 89G, 90G, 91D, 94V, 95F, 119T, 120S, 170L, 197I, 199K, 200G, 227P, 228A, 229I
CDD
cd11642 (SUMT)

227P

SAM binding site
13P, 89G, 90G, 91D, 94V, 95F, 119T, 120S, 170L, 197I, 199K, 200G, 227P, 228A, 229I
CDD
cd11642 (SUMT)

228A

SAM binding site
13P, 89G, 90G, 91D, 94V, 95F, 119T, 120S, 170L, 197I, 199K, 200G, 227P, 228A, 229I
CDD
cd11642 (SUMT)

229I

SAM binding site
13P, 89G, 90G, 91D, 94V, 95F, 119T, 120S, 170L, 197I, 199K, 200G, 227P, 228A, 229I
CDD
cd11642 (SUMT)
homodimer interfac...

17E

homodimer interface
17E, 18L, 19L, 20T, 21L, 22K, 24K, 91D, 93F, 94V, 95F, 99G, 100E, 102I, 106F, 107K, 114V, 116P, 118I, 122I, 123S, 131P, 133T, 134H, 135R, 139R, 140S, 141F, 142H, 143I
CDD
cd11642 (SUMT)

18L

homodimer interface
17E, 18L, 19L, 20T, 21L, 22K, 24K, 91D, 93F, 94V, 95F, 99G, 100E, 102I, 106F, 107K, 114V, 116P, 118I, 122I, 123S, 131P, 133T, 134H, 135R, 139R, 140S, 141F, 142H, 143I
CDD
cd11642 (SUMT)

19L

homodimer interface
17E, 18L, 19L, 20T, 21L, 22K, 24K, 91D, 93F, 94V, 95F, 99G, 100E, 102I, 106F, 107K, 114V, 116P, 118I, 122I, 123S, 131P, 133T, 134H, 135R, 139R, 140S, 141F, 142H, 143I
CDD
cd11642 (SUMT)

20T

homodimer interface
17E, 18L, 19L, 20T, 21L, 22K, 24K, 91D, 93F, 94V, 95F, 99G, 100E, 102I, 106F, 107K, 114V, 116P, 118I, 122I, 123S, 131P, 133T, 134H, 135R, 139R, 140S, 141F, 142H, 143I
CDD
cd11642 (SUMT)

21L

homodimer interface
17E, 18L, 19L, 20T, 21L, 22K, 24K, 91D, 93F, 94V, 95F, 99G, 100E, 102I, 106F, 107K, 114V, 116P, 118I, 122I, 123S, 131P, 133T, 134H, 135R, 139R, 140S, 141F, 142H, 143I
CDD
cd11642 (SUMT)

22K

homodimer interface
17E, 18L, 19L, 20T, 21L, 22K, 24K, 91D, 93F, 94V, 95F, 99G, 100E, 102I, 106F, 107K, 114V, 116P, 118I, 122I, 123S, 131P, 133T, 134H, 135R, 139R, 140S, 141F, 142H, 143I
CDD
cd11642 (SUMT)

24K

homodimer interface
17E, 18L, 19L, 20T, 21L, 22K, 24K, 91D, 93F, 94V, 95F, 99G, 100E, 102I, 106F, 107K, 114V, 116P, 118I, 122I, 123S, 131P, 133T, 134H, 135R, 139R, 140S, 141F, 142H, 143I
CDD
cd11642 (SUMT)

91D

homodimer interface
17E, 18L, 19L, 20T, 21L, 22K, 24K, 91D, 93F, 94V, 95F, 99G, 100E, 102I, 106F, 107K, 114V, 116P, 118I, 122I, 123S, 131P, 133T, 134H, 135R, 139R, 140S, 141F, 142H, 143I
CDD
cd11642 (SUMT)

93F

homodimer interface
17E, 18L, 19L, 20T, 21L, 22K, 24K, 91D, 93F, 94V, 95F, 99G, 100E, 102I, 106F, 107K, 114V, 116P, 118I, 122I, 123S, 131P, 133T, 134H, 135R, 139R, 140S, 141F, 142H, 143I
CDD
cd11642 (SUMT)

94V

homodimer interface
17E, 18L, 19L, 20T, 21L, 22K, 24K, 91D, 93F, 94V, 95F, 99G, 100E, 102I, 106F, 107K, 114V, 116P, 118I, 122I, 123S, 131P, 133T, 134H, 135R, 139R, 140S, 141F, 142H, 143I
CDD
cd11642 (SUMT)

95F

homodimer interface
17E, 18L, 19L, 20T, 21L, 22K, 24K, 91D, 93F, 94V, 95F, 99G, 100E, 102I, 106F, 107K, 114V, 116P, 118I, 122I, 123S, 131P, 133T, 134H, 135R, 139R, 140S, 141F, 142H, 143I
CDD
cd11642 (SUMT)

99G

homodimer interface
17E, 18L, 19L, 20T, 21L, 22K, 24K, 91D, 93F, 94V, 95F, 99G, 100E, 102I, 106F, 107K, 114V, 116P, 118I, 122I, 123S, 131P, 133T, 134H, 135R, 139R, 140S, 141F, 142H, 143I
CDD
cd11642 (SUMT)

100E

homodimer interface
17E, 18L, 19L, 20T, 21L, 22K, 24K, 91D, 93F, 94V, 95F, 99G, 100E, 102I, 106F, 107K, 114V, 116P, 118I, 122I, 123S, 131P, 133T, 134H, 135R, 139R, 140S, 141F, 142H, 143I
CDD
cd11642 (SUMT)

102I

homodimer interface
17E, 18L, 19L, 20T, 21L, 22K, 24K, 91D, 93F, 94V, 95F, 99G, 100E, 102I, 106F, 107K, 114V, 116P, 118I, 122I, 123S, 131P, 133T, 134H, 135R, 139R, 140S, 141F, 142H, 143I
CDD
cd11642 (SUMT)

106F

homodimer interface
17E, 18L, 19L, 20T, 21L, 22K, 24K, 91D, 93F, 94V, 95F, 99G, 100E, 102I, 106F, 107K, 114V, 116P, 118I, 122I, 123S, 131P, 133T, 134H, 135R, 139R, 140S, 141F, 142H, 143I
CDD
cd11642 (SUMT)

107K

homodimer interface
17E, 18L, 19L, 20T, 21L, 22K, 24K, 91D, 93F, 94V, 95F, 99G, 100E, 102I, 106F, 107K, 114V, 116P, 118I, 122I, 123S, 131P, 133T, 134H, 135R, 139R, 140S, 141F, 142H, 143I
CDD
cd11642 (SUMT)

114V

homodimer interface
17E, 18L, 19L, 20T, 21L, 22K, 24K, 91D, 93F, 94V, 95F, 99G, 100E, 102I, 106F, 107K, 114V, 116P, 118I, 122I, 123S, 131P, 133T, 134H, 135R, 139R, 140S, 141F, 142H, 143I
CDD
cd11642 (SUMT)

116P

homodimer interface
17E, 18L, 19L, 20T, 21L, 22K, 24K, 91D, 93F, 94V, 95F, 99G, 100E, 102I, 106F, 107K, 114V, 116P, 118I, 122I, 123S, 131P, 133T, 134H, 135R, 139R, 140S, 141F, 142H, 143I
CDD
cd11642 (SUMT)

118I

homodimer interface
17E, 18L, 19L, 20T, 21L, 22K, 24K, 91D, 93F, 94V, 95F, 99G, 100E, 102I, 106F, 107K, 114V, 116P, 118I, 122I, 123S, 131P, 133T, 134H, 135R, 139R, 140S, 141F, 142H, 143I
CDD
cd11642 (SUMT)

122I

homodimer interface
17E, 18L, 19L, 20T, 21L, 22K, 24K, 91D, 93F, 94V, 95F, 99G, 100E, 102I, 106F, 107K, 114V, 116P, 118I, 122I, 123S, 131P, 133T, 134H, 135R, 139R, 140S, 141F, 142H, 143I
CDD
cd11642 (SUMT)

123S

homodimer interface
17E, 18L, 19L, 20T, 21L, 22K, 24K, 91D, 93F, 94V, 95F, 99G, 100E, 102I, 106F, 107K, 114V, 116P, 118I, 122I, 123S, 131P, 133T, 134H, 135R, 139R, 140S, 141F, 142H, 143I
CDD
cd11642 (SUMT)

131P

homodimer interface
17E, 18L, 19L, 20T, 21L, 22K, 24K, 91D, 93F, 94V, 95F, 99G, 100E, 102I, 106F, 107K, 114V, 116P, 118I, 122I, 123S, 131P, 133T, 134H, 135R, 139R, 140S, 141F, 142H, 143I
CDD
cd11642 (SUMT)

133T

homodimer interface
17E, 18L, 19L, 20T, 21L, 22K, 24K, 91D, 93F, 94V, 95F, 99G, 100E, 102I, 106F, 107K, 114V, 116P, 118I, 122I, 123S, 131P, 133T, 134H, 135R, 139R, 140S, 141F, 142H, 143I
CDD
cd11642 (SUMT)

134H

homodimer interface
17E, 18L, 19L, 20T, 21L, 22K, 24K, 91D, 93F, 94V, 95F, 99G, 100E, 102I, 106F, 107K, 114V, 116P, 118I, 122I, 123S, 131P, 133T, 134H, 135R, 139R, 140S, 141F, 142H, 143I
CDD
cd11642 (SUMT)

135R

homodimer interface
17E, 18L, 19L, 20T, 21L, 22K, 24K, 91D, 93F, 94V, 95F, 99G, 100E, 102I, 106F, 107K, 114V, 116P, 118I, 122I, 123S, 131P, 133T, 134H, 135R, 139R, 140S, 141F, 142H, 143I
CDD
cd11642 (SUMT)

139R

homodimer interface
17E, 18L, 19L, 20T, 21L, 22K, 24K, 91D, 93F, 94V, 95F, 99G, 100E, 102I, 106F, 107K, 114V, 116P, 118I, 122I, 123S, 131P, 133T, 134H, 135R, 139R, 140S, 141F, 142H, 143I
CDD
cd11642 (SUMT)

140S

homodimer interface
17E, 18L, 19L, 20T, 21L, 22K, 24K, 91D, 93F, 94V, 95F, 99G, 100E, 102I, 106F, 107K, 114V, 116P, 118I, 122I, 123S, 131P, 133T, 134H, 135R, 139R, 140S, 141F, 142H, 143I
CDD
cd11642 (SUMT)

141F

homodimer interface
17E, 18L, 19L, 20T, 21L, 22K, 24K, 91D, 93F, 94V, 95F, 99G, 100E, 102I, 106F, 107K, 114V, 116P, 118I, 122I, 123S, 131P, 133T, 134H, 135R, 139R, 140S, 141F, 142H, 143I
CDD
cd11642 (SUMT)

142H

homodimer interface
17E, 18L, 19L, 20T, 21L, 22K, 24K, 91D, 93F, 94V, 95F, 99G, 100E, 102I, 106F, 107K, 114V, 116P, 118I, 122I, 123S, 131P, 133T, 134H, 135R, 139R, 140S, 141F, 142H, 143I
CDD
cd11642 (SUMT)

143I

homodimer interface
17E, 18L, 19L, 20T, 21L, 22K, 24K, 91D, 93F, 94V, 95F, 99G, 100E, 102I, 106F, 107K, 114V, 116P, 118I, 122I, 123S, 131P, 133T, 134H, 135R, 139R, 140S, 141F, 142H, 143I
CDD
cd11642 (SUMT)
active site cd06578

258R

active site
258R, 305S, 306P, 307N, 333K, 376S, 400Y, 402T, 425L, 426S, 427S, 428S, 429T
CDD
cd06578 (HemD)

305S

active site
258R, 305S, 306P, 307N, 333K, 376S, 400Y, 402T, 425L, 426S, 427S, 428S, 429T
CDD
cd06578 (HemD)

306P

active site
258R, 305S, 306P, 307N, 333K, 376S, 400Y, 402T, 425L, 426S, 427S, 428S, 429T
CDD
cd06578 (HemD)

307N

active site
258R, 305S, 306P, 307N, 333K, 376S, 400Y, 402T, 425L, 426S, 427S, 428S, 429T
CDD
cd06578 (HemD)

333K

active site
258R, 305S, 306P, 307N, 333K, 376S, 400Y, 402T, 425L, 426S, 427S, 428S, 429T
CDD
cd06578 (HemD)

376S

active site
258R, 305S, 306P, 307N, 333K, 376S, 400Y, 402T, 425L, 426S, 427S, 428S, 429T
CDD
cd06578 (HemD)

400Y

active site
258R, 305S, 306P, 307N, 333K, 376S, 400Y, 402T, 425L, 426S, 427S, 428S, 429T
CDD
cd06578 (HemD)

402T

active site
258R, 305S, 306P, 307N, 333K, 376S, 400Y, 402T, 425L, 426S, 427S, 428S, 429T
CDD
cd06578 (HemD)

425L

active site
258R, 305S, 306P, 307N, 333K, 376S, 400Y, 402T, 425L, 426S, 427S, 428S, 429T
CDD
cd06578 (HemD)

426S

active site
258R, 305S, 306P, 307N, 333K, 376S, 400Y, 402T, 425L, 426S, 427S, 428S, 429T
CDD
cd06578 (HemD)

427S

active site
258R, 305S, 306P, 307N, 333K, 376S, 400Y, 402T, 425L, 426S, 427S, 428S, 429T
CDD
cd06578 (HemD)

428S

active site
258R, 305S, 306P, 307N, 333K, 376S, 400Y, 402T, 425L, 426S, 427S, 428S, 429T
CDD
cd06578 (HemD)

429T

active site
258R, 305S, 306P, 307N, 333K, 376S, 400Y, 402T, 425L, 426S, 427S, 428S, 429T
CDD
cd06578 (HemD)

GO term prediction

Biological Process

GO:0006779 porphyrin-containing compound biosynthetic process
GO:0008152 metabolic process
GO:0009236 cobalamin biosynthetic process
GO:0019354 siroheme biosynthetic process
GO:0033014 tetrapyrrole biosynthetic process
GO:0055114 oxidation-reduction process

Molecular Function

GO:0004851 uroporphyrin-III C-methyltransferase activity
GO:0004852 uroporphyrinogen-III synthase activity
GO:0008168 methyltransferase activity
GO:0043115 precorrin-2 dehydrogenase activity
GO:0051266 sirohydrochlorin ferrochelatase activity
GO:0051287 NAD binding

Cellular Component

None predicted.

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Entry type

Status

Per-residue features