23726_FusoPortal_Gene_1783

Protein

23726_FusoPortal_Gene_1783

Length

637 amino acids

Protein family membership

Threonine-tRNA ligase, class IIa (IPR002320)

Homologous superfamilies

Homologous superfamily
4 - 61
Beta-grasp domain superfamily (IPR012675)
Homologous superfamily
6 - 59
TGS-like (IPR012676)
61 - 239
Threonyl/alanyl tRNA synthetase, class II-like, putative editing domain superfamily (IPR018163)
527 - 634
Anticodon-binding domain superfamily (IPR036621)

1 100 200 300 400 500 637

Domains and repeats

Domain
7 - 58
TGS (IPR004095)
168 - 217
Threonyl/alanyl tRNA synthetase, SAD (IPR012947)
241 - 537
Aminoacyl-tRNA synthetase, class II (IPR006195)
Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) (IPR002314)
Threonine-tRNA ligase catalytic core domain (IPR033728)
539 - 628
Anticodon-binding (IPR004154)

1 100 200 300 400 500 637

Detailed signature matches

IPR012675

Beta-grasp domain superfamily
1. G3DSA:3.10.20.30
  
  4 - 61
  
  GENE3D
  G3DSA:3.10.20.30 (G3DSA:3.10.20.30)
IPR012676

TGS-like
1. SSF81271 (TGS-like)
  
  6 - 59
  
  SUPERFAMILY
  SSF81271 (TGS-like)
IPR018163

Threonyl/alanyl tRNA synthetase, class II-like, putative editing domain superfamily
1. SSF55186 (ThrRS/Ala...)
  
  61 - 239
  
  SUPERFAMILY
  SSF55186 (ThrRS/AlaRS common domain)
IPR036621

Anticodon-binding domain superfamily
1. SSF52954 (Class II ...)
  
  527 - 630
  
  SUPERFAMILY
  SSF52954 (Class II aaRS ABD-related)
2. G3DSA:3.40.50...
  
  530 - 634
  
  GENE3D
  G3DSA:3.40.50.800 (G3DSA:3.40.50.800)
IPR002320

Threonine-tRNA ligase, class IIa
1. TIGR00418
  
  70 - 629
  
  TIGRFAMs
  TIGR00418 (TIGR00418)
2. MF_00184 (Thr_tRNA_...)
  
  64 - 633
  
  HAMAP
  MF_00184 (Thr_tRNA_synth)
3. PR01047 (TRNASYNTHTHR)
  
  532 - 544
  
  PRINTS
  PR01047 (TRNASYNTHTHR)
  
  360 - 383
  
  PRINTS
  PR01047 (TRNASYNTHTHR)
  
  505 - 518
  
  PRINTS
  PR01047 (TRNASYNTHTHR)
  
  327 - 355
  
  PRINTS
  PR01047 (TRNASYNTHTHR)
  
  462 - 490
  
  PRINTS
  PR01047 (TRNASYNTHTHR)
4. PTHR11451 (TRNA SYN...)
  
  6 - 632
  
  PANTHER
  PTHR11451 (TRNA SYNTHETASE-RELATED)
IPR004095

TGS
1. PF02824 (TGS)
  
  7 - 58
  
  Pfam
  PF02824 (TGS)
IPR012947

Threonyl/alanyl tRNA synthetase, SAD
1. PF07973 (tRNA_SAD)
  
  168 - 217
  
  Pfam
  PF07973 (tRNA_SAD)
IPR006195

Aminoacyl-tRNA synthetase, class II
1. PS50862 (AA_TRNA_LI...)
  
  266 - 532
  
  PROSITE profiles
  PS50862 (AA_TRNA_LIGASE_II)
IPR002314

Aminoacyl-tRNA synthetase, class II (G/ P/ S/T)
1. PF00587 (tRNA-synt_2b)
  
  317 - 527
  
  Pfam
  PF00587 (tRNA-synt_2b)
IPR033728

Threonine-tRNA ligase catalytic core domain
1. cd00771 (ThrRS_core)
  
  241 - 537
  
  CDD
  cd00771 (ThrRS_core)
IPR004154

Anticodon-binding
1. PF03129 (HGTP_antic...)
  
  539 - 628
  
  Pfam
  PF03129 (HGTP_anticodon)

no IPR

Unintegrated signatures

Coil

108 - 135

COILS
Coil (Coil)
G3DSA:3.30.93...

227 - 529

GENE3D
G3DSA:3.30.930.10 (G3DSA:3.30.930.10)
G3DSA:3.30.98...

68 - 226

GENE3D
G3DSA:3.30.980.10 (G3DSA:3.30.980.10)
PTHR11451:SF31 (THR...)

6 - 632

PANTHER
PTHR11451:SF31 (THREONINE--TRNA LIGASE)
SSF55681 (Class II ...)

241 - 524

SUPERFAMILY
SSF55681 (Class II aaRS and biotin synthetases)
cd00860 (ThrRS_anti...)

537 - 623

CDD
cd00860 (ThrRS_anticodon)
cd01667 (TGS_ThrRS_N)

6 - 60

CDD
cd01667 (TGS_ThrRS_N)

Residue annotation

active site cd00771

244K

active site
244K, 256E, 307H, 311Y, 314N, 315M, 329P, 361R, 363E, 365S, 366G, 367A, 372M, 373R, 374V, 377F, 379Q, 474R, 477Q, 478C, 482Q, 514G, 515S, 518R
CDD
cd00771 (ThrRS_core)

256E

active site
244K, 256E, 307H, 311Y, 314N, 315M, 329P, 361R, 363E, 365S, 366G, 367A, 372M, 373R, 374V, 377F, 379Q, 474R, 477Q, 478C, 482Q, 514G, 515S, 518R
CDD
cd00771 (ThrRS_core)

307H

active site
244K, 256E, 307H, 311Y, 314N, 315M, 329P, 361R, 363E, 365S, 366G, 367A, 372M, 373R, 374V, 377F, 379Q, 474R, 477Q, 478C, 482Q, 514G, 515S, 518R
CDD
cd00771 (ThrRS_core)

311Y

active site
244K, 256E, 307H, 311Y, 314N, 315M, 329P, 361R, 363E, 365S, 366G, 367A, 372M, 373R, 374V, 377F, 379Q, 474R, 477Q, 478C, 482Q, 514G, 515S, 518R
CDD
cd00771 (ThrRS_core)

314N

active site
244K, 256E, 307H, 311Y, 314N, 315M, 329P, 361R, 363E, 365S, 366G, 367A, 372M, 373R, 374V, 377F, 379Q, 474R, 477Q, 478C, 482Q, 514G, 515S, 518R
CDD
cd00771 (ThrRS_core)

315M

active site
244K, 256E, 307H, 311Y, 314N, 315M, 329P, 361R, 363E, 365S, 366G, 367A, 372M, 373R, 374V, 377F, 379Q, 474R, 477Q, 478C, 482Q, 514G, 515S, 518R
CDD
cd00771 (ThrRS_core)

329P

active site
244K, 256E, 307H, 311Y, 314N, 315M, 329P, 361R, 363E, 365S, 366G, 367A, 372M, 373R, 374V, 377F, 379Q, 474R, 477Q, 478C, 482Q, 514G, 515S, 518R
CDD
cd00771 (ThrRS_core)

361R

active site
244K, 256E, 307H, 311Y, 314N, 315M, 329P, 361R, 363E, 365S, 366G, 367A, 372M, 373R, 374V, 377F, 379Q, 474R, 477Q, 478C, 482Q, 514G, 515S, 518R
CDD
cd00771 (ThrRS_core)

363E

active site
244K, 256E, 307H, 311Y, 314N, 315M, 329P, 361R, 363E, 365S, 366G, 367A, 372M, 373R, 374V, 377F, 379Q, 474R, 477Q, 478C, 482Q, 514G, 515S, 518R
CDD
cd00771 (ThrRS_core)

365S

active site
244K, 256E, 307H, 311Y, 314N, 315M, 329P, 361R, 363E, 365S, 366G, 367A, 372M, 373R, 374V, 377F, 379Q, 474R, 477Q, 478C, 482Q, 514G, 515S, 518R
CDD
cd00771 (ThrRS_core)

366G

active site
244K, 256E, 307H, 311Y, 314N, 315M, 329P, 361R, 363E, 365S, 366G, 367A, 372M, 373R, 374V, 377F, 379Q, 474R, 477Q, 478C, 482Q, 514G, 515S, 518R
CDD
cd00771 (ThrRS_core)

367A

active site
244K, 256E, 307H, 311Y, 314N, 315M, 329P, 361R, 363E, 365S, 366G, 367A, 372M, 373R, 374V, 377F, 379Q, 474R, 477Q, 478C, 482Q, 514G, 515S, 518R
CDD
cd00771 (ThrRS_core)

372M

active site
244K, 256E, 307H, 311Y, 314N, 315M, 329P, 361R, 363E, 365S, 366G, 367A, 372M, 373R, 374V, 377F, 379Q, 474R, 477Q, 478C, 482Q, 514G, 515S, 518R
CDD
cd00771 (ThrRS_core)

373R

active site
244K, 256E, 307H, 311Y, 314N, 315M, 329P, 361R, 363E, 365S, 366G, 367A, 372M, 373R, 374V, 377F, 379Q, 474R, 477Q, 478C, 482Q, 514G, 515S, 518R
CDD
cd00771 (ThrRS_core)

374V

active site
244K, 256E, 307H, 311Y, 314N, 315M, 329P, 361R, 363E, 365S, 366G, 367A, 372M, 373R, 374V, 377F, 379Q, 474R, 477Q, 478C, 482Q, 514G, 515S, 518R
CDD
cd00771 (ThrRS_core)

377F

active site
244K, 256E, 307H, 311Y, 314N, 315M, 329P, 361R, 363E, 365S, 366G, 367A, 372M, 373R, 374V, 377F, 379Q, 474R, 477Q, 478C, 482Q, 514G, 515S, 518R
CDD
cd00771 (ThrRS_core)

379Q

active site
244K, 256E, 307H, 311Y, 314N, 315M, 329P, 361R, 363E, 365S, 366G, 367A, 372M, 373R, 374V, 377F, 379Q, 474R, 477Q, 478C, 482Q, 514G, 515S, 518R
CDD
cd00771 (ThrRS_core)

474R

active site
244K, 256E, 307H, 311Y, 314N, 315M, 329P, 361R, 363E, 365S, 366G, 367A, 372M, 373R, 374V, 377F, 379Q, 474R, 477Q, 478C, 482Q, 514G, 515S, 518R
CDD
cd00771 (ThrRS_core)

477Q

active site
244K, 256E, 307H, 311Y, 314N, 315M, 329P, 361R, 363E, 365S, 366G, 367A, 372M, 373R, 374V, 377F, 379Q, 474R, 477Q, 478C, 482Q, 514G, 515S, 518R
CDD
cd00771 (ThrRS_core)

478C

active site
244K, 256E, 307H, 311Y, 314N, 315M, 329P, 361R, 363E, 365S, 366G, 367A, 372M, 373R, 374V, 377F, 379Q, 474R, 477Q, 478C, 482Q, 514G, 515S, 518R
CDD
cd00771 (ThrRS_core)

482Q

active site
244K, 256E, 307H, 311Y, 314N, 315M, 329P, 361R, 363E, 365S, 366G, 367A, 372M, 373R, 374V, 377F, 379Q, 474R, 477Q, 478C, 482Q, 514G, 515S, 518R
CDD
cd00771 (ThrRS_core)

514G

active site
244K, 256E, 307H, 311Y, 314N, 315M, 329P, 361R, 363E, 365S, 366G, 367A, 372M, 373R, 374V, 377F, 379Q, 474R, 477Q, 478C, 482Q, 514G, 515S, 518R
CDD
cd00771 (ThrRS_core)

515S

active site
244K, 256E, 307H, 311Y, 314N, 315M, 329P, 361R, 363E, 365S, 366G, 367A, 372M, 373R, 374V, 377F, 379Q, 474R, 477Q, 478C, 482Q, 514G, 515S, 518R
CDD
cd00771 (ThrRS_core)

518R

active site
244K, 256E, 307H, 311Y, 314N, 315M, 329P, 361R, 363E, 365S, 366G, 367A, 372M, 373R, 374V, 377F, 379Q, 474R, 477Q, 478C, 482Q, 514G, 515S, 518R
CDD
cd00771 (ThrRS_core)
dimer interface cd...

248E

dimer interface
248E, 254L, 256E, 257Y, 259P, 261F, 263F, 264F, 266P, 269M, 284E, 285K, 289Q, 290Q, 292E, 294P, 295I, 296M, 298N, 316Y, 317T, 318S, 320I, 321D, 322E, 323L, 325F, 337L, 338A, 341H, 342Q, 343L, 345S, 346Y, 347K, 360H, 362H, 365S, 375R, 376S, 403D, 445K, 446L, 447G, 496I, 498E
CDD
cd00771 (ThrRS_core)

254L

dimer interface
248E, 254L, 256E, 257Y, 259P, 261F, 263F, 264F, 266P, 269M, 284E, 285K, 289Q, 290Q, 292E, 294P, 295I, 296M, 298N, 316Y, 317T, 318S, 320I, 321D, 322E, 323L, 325F, 337L, 338A, 341H, 342Q, 343L, 345S, 346Y, 347K, 360H, 362H, 365S, 375R, 376S, 403D, 445K, 446L, 447G, 496I, 498E
CDD
cd00771 (ThrRS_core)

256E

dimer interface
248E, 254L, 256E, 257Y, 259P, 261F, 263F, 264F, 266P, 269M, 284E, 285K, 289Q, 290Q, 292E, 294P, 295I, 296M, 298N, 316Y, 317T, 318S, 320I, 321D, 322E, 323L, 325F, 337L, 338A, 341H, 342Q, 343L, 345S, 346Y, 347K, 360H, 362H, 365S, 375R, 376S, 403D, 445K, 446L, 447G, 496I, 498E
CDD
cd00771 (ThrRS_core)

257Y

dimer interface
248E, 254L, 256E, 257Y, 259P, 261F, 263F, 264F, 266P, 269M, 284E, 285K, 289Q, 290Q, 292E, 294P, 295I, 296M, 298N, 316Y, 317T, 318S, 320I, 321D, 322E, 323L, 325F, 337L, 338A, 341H, 342Q, 343L, 345S, 346Y, 347K, 360H, 362H, 365S, 375R, 376S, 403D, 445K, 446L, 447G, 496I, 498E
CDD
cd00771 (ThrRS_core)

259P

dimer interface
248E, 254L, 256E, 257Y, 259P, 261F, 263F, 264F, 266P, 269M, 284E, 285K, 289Q, 290Q, 292E, 294P, 295I, 296M, 298N, 316Y, 317T, 318S, 320I, 321D, 322E, 323L, 325F, 337L, 338A, 341H, 342Q, 343L, 345S, 346Y, 347K, 360H, 362H, 365S, 375R, 376S, 403D, 445K, 446L, 447G, 496I, 498E
CDD
cd00771 (ThrRS_core)

261F

dimer interface
248E, 254L, 256E, 257Y, 259P, 261F, 263F, 264F, 266P, 269M, 284E, 285K, 289Q, 290Q, 292E, 294P, 295I, 296M, 298N, 316Y, 317T, 318S, 320I, 321D, 322E, 323L, 325F, 337L, 338A, 341H, 342Q, 343L, 345S, 346Y, 347K, 360H, 362H, 365S, 375R, 376S, 403D, 445K, 446L, 447G, 496I, 498E
CDD
cd00771 (ThrRS_core)

263F

dimer interface
248E, 254L, 256E, 257Y, 259P, 261F, 263F, 264F, 266P, 269M, 284E, 285K, 289Q, 290Q, 292E, 294P, 295I, 296M, 298N, 316Y, 317T, 318S, 320I, 321D, 322E, 323L, 325F, 337L, 338A, 341H, 342Q, 343L, 345S, 346Y, 347K, 360H, 362H, 365S, 375R, 376S, 403D, 445K, 446L, 447G, 496I, 498E
CDD
cd00771 (ThrRS_core)

264F

dimer interface
248E, 254L, 256E, 257Y, 259P, 261F, 263F, 264F, 266P, 269M, 284E, 285K, 289Q, 290Q, 292E, 294P, 295I, 296M, 298N, 316Y, 317T, 318S, 320I, 321D, 322E, 323L, 325F, 337L, 338A, 341H, 342Q, 343L, 345S, 346Y, 347K, 360H, 362H, 365S, 375R, 376S, 403D, 445K, 446L, 447G, 496I, 498E
CDD
cd00771 (ThrRS_core)

266P

dimer interface
248E, 254L, 256E, 257Y, 259P, 261F, 263F, 264F, 266P, 269M, 284E, 285K, 289Q, 290Q, 292E, 294P, 295I, 296M, 298N, 316Y, 317T, 318S, 320I, 321D, 322E, 323L, 325F, 337L, 338A, 341H, 342Q, 343L, 345S, 346Y, 347K, 360H, 362H, 365S, 375R, 376S, 403D, 445K, 446L, 447G, 496I, 498E
CDD
cd00771 (ThrRS_core)

269M

dimer interface
248E, 254L, 256E, 257Y, 259P, 261F, 263F, 264F, 266P, 269M, 284E, 285K, 289Q, 290Q, 292E, 294P, 295I, 296M, 298N, 316Y, 317T, 318S, 320I, 321D, 322E, 323L, 325F, 337L, 338A, 341H, 342Q, 343L, 345S, 346Y, 347K, 360H, 362H, 365S, 375R, 376S, 403D, 445K, 446L, 447G, 496I, 498E
CDD
cd00771 (ThrRS_core)

284E

dimer interface
248E, 254L, 256E, 257Y, 259P, 261F, 263F, 264F, 266P, 269M, 284E, 285K, 289Q, 290Q, 292E, 294P, 295I, 296M, 298N, 316Y, 317T, 318S, 320I, 321D, 322E, 323L, 325F, 337L, 338A, 341H, 342Q, 343L, 345S, 346Y, 347K, 360H, 362H, 365S, 375R, 376S, 403D, 445K, 446L, 447G, 496I, 498E
CDD
cd00771 (ThrRS_core)

285K

dimer interface
248E, 254L, 256E, 257Y, 259P, 261F, 263F, 264F, 266P, 269M, 284E, 285K, 289Q, 290Q, 292E, 294P, 295I, 296M, 298N, 316Y, 317T, 318S, 320I, 321D, 322E, 323L, 325F, 337L, 338A, 341H, 342Q, 343L, 345S, 346Y, 347K, 360H, 362H, 365S, 375R, 376S, 403D, 445K, 446L, 447G, 496I, 498E
CDD
cd00771 (ThrRS_core)

289Q

dimer interface
248E, 254L, 256E, 257Y, 259P, 261F, 263F, 264F, 266P, 269M, 284E, 285K, 289Q, 290Q, 292E, 294P, 295I, 296M, 298N, 316Y, 317T, 318S, 320I, 321D, 322E, 323L, 325F, 337L, 338A, 341H, 342Q, 343L, 345S, 346Y, 347K, 360H, 362H, 365S, 375R, 376S, 403D, 445K, 446L, 447G, 496I, 498E
CDD
cd00771 (ThrRS_core)

290Q

dimer interface
248E, 254L, 256E, 257Y, 259P, 261F, 263F, 264F, 266P, 269M, 284E, 285K, 289Q, 290Q, 292E, 294P, 295I, 296M, 298N, 316Y, 317T, 318S, 320I, 321D, 322E, 323L, 325F, 337L, 338A, 341H, 342Q, 343L, 345S, 346Y, 347K, 360H, 362H, 365S, 375R, 376S, 403D, 445K, 446L, 447G, 496I, 498E
CDD
cd00771 (ThrRS_core)

292E

dimer interface
248E, 254L, 256E, 257Y, 259P, 261F, 263F, 264F, 266P, 269M, 284E, 285K, 289Q, 290Q, 292E, 294P, 295I, 296M, 298N, 316Y, 317T, 318S, 320I, 321D, 322E, 323L, 325F, 337L, 338A, 341H, 342Q, 343L, 345S, 346Y, 347K, 360H, 362H, 365S, 375R, 376S, 403D, 445K, 446L, 447G, 496I, 498E
CDD
cd00771 (ThrRS_core)

294P

dimer interface
248E, 254L, 256E, 257Y, 259P, 261F, 263F, 264F, 266P, 269M, 284E, 285K, 289Q, 290Q, 292E, 294P, 295I, 296M, 298N, 316Y, 317T, 318S, 320I, 321D, 322E, 323L, 325F, 337L, 338A, 341H, 342Q, 343L, 345S, 346Y, 347K, 360H, 362H, 365S, 375R, 376S, 403D, 445K, 446L, 447G, 496I, 498E
CDD
cd00771 (ThrRS_core)

295I

dimer interface
248E, 254L, 256E, 257Y, 259P, 261F, 263F, 264F, 266P, 269M, 284E, 285K, 289Q, 290Q, 292E, 294P, 295I, 296M, 298N, 316Y, 317T, 318S, 320I, 321D, 322E, 323L, 325F, 337L, 338A, 341H, 342Q, 343L, 345S, 346Y, 347K, 360H, 362H, 365S, 375R, 376S, 403D, 445K, 446L, 447G, 496I, 498E
CDD
cd00771 (ThrRS_core)

296M

dimer interface
248E, 254L, 256E, 257Y, 259P, 261F, 263F, 264F, 266P, 269M, 284E, 285K, 289Q, 290Q, 292E, 294P, 295I, 296M, 298N, 316Y, 317T, 318S, 320I, 321D, 322E, 323L, 325F, 337L, 338A, 341H, 342Q, 343L, 345S, 346Y, 347K, 360H, 362H, 365S, 375R, 376S, 403D, 445K, 446L, 447G, 496I, 498E
CDD
cd00771 (ThrRS_core)

298N

dimer interface
248E, 254L, 256E, 257Y, 259P, 261F, 263F, 264F, 266P, 269M, 284E, 285K, 289Q, 290Q, 292E, 294P, 295I, 296M, 298N, 316Y, 317T, 318S, 320I, 321D, 322E, 323L, 325F, 337L, 338A, 341H, 342Q, 343L, 345S, 346Y, 347K, 360H, 362H, 365S, 375R, 376S, 403D, 445K, 446L, 447G, 496I, 498E
CDD
cd00771 (ThrRS_core)

316Y

dimer interface
248E, 254L, 256E, 257Y, 259P, 261F, 263F, 264F, 266P, 269M, 284E, 285K, 289Q, 290Q, 292E, 294P, 295I, 296M, 298N, 316Y, 317T, 318S, 320I, 321D, 322E, 323L, 325F, 337L, 338A, 341H, 342Q, 343L, 345S, 346Y, 347K, 360H, 362H, 365S, 375R, 376S, 403D, 445K, 446L, 447G, 496I, 498E
CDD
cd00771 (ThrRS_core)

317T

dimer interface
248E, 254L, 256E, 257Y, 259P, 261F, 263F, 264F, 266P, 269M, 284E, 285K, 289Q, 290Q, 292E, 294P, 295I, 296M, 298N, 316Y, 317T, 318S, 320I, 321D, 322E, 323L, 325F, 337L, 338A, 341H, 342Q, 343L, 345S, 346Y, 347K, 360H, 362H, 365S, 375R, 376S, 403D, 445K, 446L, 447G, 496I, 498E
CDD
cd00771 (ThrRS_core)

318S

dimer interface
248E, 254L, 256E, 257Y, 259P, 261F, 263F, 264F, 266P, 269M, 284E, 285K, 289Q, 290Q, 292E, 294P, 295I, 296M, 298N, 316Y, 317T, 318S, 320I, 321D, 322E, 323L, 325F, 337L, 338A, 341H, 342Q, 343L, 345S, 346Y, 347K, 360H, 362H, 365S, 375R, 376S, 403D, 445K, 446L, 447G, 496I, 498E
CDD
cd00771 (ThrRS_core)

320I

dimer interface
248E, 254L, 256E, 257Y, 259P, 261F, 263F, 264F, 266P, 269M, 284E, 285K, 289Q, 290Q, 292E, 294P, 295I, 296M, 298N, 316Y, 317T, 318S, 320I, 321D, 322E, 323L, 325F, 337L, 338A, 341H, 342Q, 343L, 345S, 346Y, 347K, 360H, 362H, 365S, 375R, 376S, 403D, 445K, 446L, 447G, 496I, 498E
CDD
cd00771 (ThrRS_core)

321D

dimer interface
248E, 254L, 256E, 257Y, 259P, 261F, 263F, 264F, 266P, 269M, 284E, 285K, 289Q, 290Q, 292E, 294P, 295I, 296M, 298N, 316Y, 317T, 318S, 320I, 321D, 322E, 323L, 325F, 337L, 338A, 341H, 342Q, 343L, 345S, 346Y, 347K, 360H, 362H, 365S, 375R, 376S, 403D, 445K, 446L, 447G, 496I, 498E
CDD
cd00771 (ThrRS_core)

322E

dimer interface
248E, 254L, 256E, 257Y, 259P, 261F, 263F, 264F, 266P, 269M, 284E, 285K, 289Q, 290Q, 292E, 294P, 295I, 296M, 298N, 316Y, 317T, 318S, 320I, 321D, 322E, 323L, 325F, 337L, 338A, 341H, 342Q, 343L, 345S, 346Y, 347K, 360H, 362H, 365S, 375R, 376S, 403D, 445K, 446L, 447G, 496I, 498E
CDD
cd00771 (ThrRS_core)

323L

dimer interface
248E, 254L, 256E, 257Y, 259P, 261F, 263F, 264F, 266P, 269M, 284E, 285K, 289Q, 290Q, 292E, 294P, 295I, 296M, 298N, 316Y, 317T, 318S, 320I, 321D, 322E, 323L, 325F, 337L, 338A, 341H, 342Q, 343L, 345S, 346Y, 347K, 360H, 362H, 365S, 375R, 376S, 403D, 445K, 446L, 447G, 496I, 498E
CDD
cd00771 (ThrRS_core)

325F

dimer interface
248E, 254L, 256E, 257Y, 259P, 261F, 263F, 264F, 266P, 269M, 284E, 285K, 289Q, 290Q, 292E, 294P, 295I, 296M, 298N, 316Y, 317T, 318S, 320I, 321D, 322E, 323L, 325F, 337L, 338A, 341H, 342Q, 343L, 345S, 346Y, 347K, 360H, 362H, 365S, 375R, 376S, 403D, 445K, 446L, 447G, 496I, 498E
CDD
cd00771 (ThrRS_core)

337L

dimer interface
248E, 254L, 256E, 257Y, 259P, 261F, 263F, 264F, 266P, 269M, 284E, 285K, 289Q, 290Q, 292E, 294P, 295I, 296M, 298N, 316Y, 317T, 318S, 320I, 321D, 322E, 323L, 325F, 337L, 338A, 341H, 342Q, 343L, 345S, 346Y, 347K, 360H, 362H, 365S, 375R, 376S, 403D, 445K, 446L, 447G, 496I, 498E
CDD
cd00771 (ThrRS_core)

338A

dimer interface
248E, 254L, 256E, 257Y, 259P, 261F, 263F, 264F, 266P, 269M, 284E, 285K, 289Q, 290Q, 292E, 294P, 295I, 296M, 298N, 316Y, 317T, 318S, 320I, 321D, 322E, 323L, 325F, 337L, 338A, 341H, 342Q, 343L, 345S, 346Y, 347K, 360H, 362H, 365S, 375R, 376S, 403D, 445K, 446L, 447G, 496I, 498E
CDD
cd00771 (ThrRS_core)

341H

dimer interface
248E, 254L, 256E, 257Y, 259P, 261F, 263F, 264F, 266P, 269M, 284E, 285K, 289Q, 290Q, 292E, 294P, 295I, 296M, 298N, 316Y, 317T, 318S, 320I, 321D, 322E, 323L, 325F, 337L, 338A, 341H, 342Q, 343L, 345S, 346Y, 347K, 360H, 362H, 365S, 375R, 376S, 403D, 445K, 446L, 447G, 496I, 498E
CDD
cd00771 (ThrRS_core)

342Q

dimer interface
248E, 254L, 256E, 257Y, 259P, 261F, 263F, 264F, 266P, 269M, 284E, 285K, 289Q, 290Q, 292E, 294P, 295I, 296M, 298N, 316Y, 317T, 318S, 320I, 321D, 322E, 323L, 325F, 337L, 338A, 341H, 342Q, 343L, 345S, 346Y, 347K, 360H, 362H, 365S, 375R, 376S, 403D, 445K, 446L, 447G, 496I, 498E
CDD
cd00771 (ThrRS_core)

343L

dimer interface
248E, 254L, 256E, 257Y, 259P, 261F, 263F, 264F, 266P, 269M, 284E, 285K, 289Q, 290Q, 292E, 294P, 295I, 296M, 298N, 316Y, 317T, 318S, 320I, 321D, 322E, 323L, 325F, 337L, 338A, 341H, 342Q, 343L, 345S, 346Y, 347K, 360H, 362H, 365S, 375R, 376S, 403D, 445K, 446L, 447G, 496I, 498E
CDD
cd00771 (ThrRS_core)

345S

dimer interface
248E, 254L, 256E, 257Y, 259P, 261F, 263F, 264F, 266P, 269M, 284E, 285K, 289Q, 290Q, 292E, 294P, 295I, 296M, 298N, 316Y, 317T, 318S, 320I, 321D, 322E, 323L, 325F, 337L, 338A, 341H, 342Q, 343L, 345S, 346Y, 347K, 360H, 362H, 365S, 375R, 376S, 403D, 445K, 446L, 447G, 496I, 498E
CDD
cd00771 (ThrRS_core)

346Y

dimer interface
248E, 254L, 256E, 257Y, 259P, 261F, 263F, 264F, 266P, 269M, 284E, 285K, 289Q, 290Q, 292E, 294P, 295I, 296M, 298N, 316Y, 317T, 318S, 320I, 321D, 322E, 323L, 325F, 337L, 338A, 341H, 342Q, 343L, 345S, 346Y, 347K, 360H, 362H, 365S, 375R, 376S, 403D, 445K, 446L, 447G, 496I, 498E
CDD
cd00771 (ThrRS_core)

347K

dimer interface
248E, 254L, 256E, 257Y, 259P, 261F, 263F, 264F, 266P, 269M, 284E, 285K, 289Q, 290Q, 292E, 294P, 295I, 296M, 298N, 316Y, 317T, 318S, 320I, 321D, 322E, 323L, 325F, 337L, 338A, 341H, 342Q, 343L, 345S, 346Y, 347K, 360H, 362H, 365S, 375R, 376S, 403D, 445K, 446L, 447G, 496I, 498E
CDD
cd00771 (ThrRS_core)

360H

dimer interface
248E, 254L, 256E, 257Y, 259P, 261F, 263F, 264F, 266P, 269M, 284E, 285K, 289Q, 290Q, 292E, 294P, 295I, 296M, 298N, 316Y, 317T, 318S, 320I, 321D, 322E, 323L, 325F, 337L, 338A, 341H, 342Q, 343L, 345S, 346Y, 347K, 360H, 362H, 365S, 375R, 376S, 403D, 445K, 446L, 447G, 496I, 498E
CDD
cd00771 (ThrRS_core)

362H

dimer interface
248E, 254L, 256E, 257Y, 259P, 261F, 263F, 264F, 266P, 269M, 284E, 285K, 289Q, 290Q, 292E, 294P, 295I, 296M, 298N, 316Y, 317T, 318S, 320I, 321D, 322E, 323L, 325F, 337L, 338A, 341H, 342Q, 343L, 345S, 346Y, 347K, 360H, 362H, 365S, 375R, 376S, 403D, 445K, 446L, 447G, 496I, 498E
CDD
cd00771 (ThrRS_core)

365S

dimer interface
248E, 254L, 256E, 257Y, 259P, 261F, 263F, 264F, 266P, 269M, 284E, 285K, 289Q, 290Q, 292E, 294P, 295I, 296M, 298N, 316Y, 317T, 318S, 320I, 321D, 322E, 323L, 325F, 337L, 338A, 341H, 342Q, 343L, 345S, 346Y, 347K, 360H, 362H, 365S, 375R, 376S, 403D, 445K, 446L, 447G, 496I, 498E
CDD
cd00771 (ThrRS_core)

375R

dimer interface
248E, 254L, 256E, 257Y, 259P, 261F, 263F, 264F, 266P, 269M, 284E, 285K, 289Q, 290Q, 292E, 294P, 295I, 296M, 298N, 316Y, 317T, 318S, 320I, 321D, 322E, 323L, 325F, 337L, 338A, 341H, 342Q, 343L, 345S, 346Y, 347K, 360H, 362H, 365S, 375R, 376S, 403D, 445K, 446L, 447G, 496I, 498E
CDD
cd00771 (ThrRS_core)

376S

dimer interface
248E, 254L, 256E, 257Y, 259P, 261F, 263F, 264F, 266P, 269M, 284E, 285K, 289Q, 290Q, 292E, 294P, 295I, 296M, 298N, 316Y, 317T, 318S, 320I, 321D, 322E, 323L, 325F, 337L, 338A, 341H, 342Q, 343L, 345S, 346Y, 347K, 360H, 362H, 365S, 375R, 376S, 403D, 445K, 446L, 447G, 496I, 498E
CDD
cd00771 (ThrRS_core)

403D

dimer interface
248E, 254L, 256E, 257Y, 259P, 261F, 263F, 264F, 266P, 269M, 284E, 285K, 289Q, 290Q, 292E, 294P, 295I, 296M, 298N, 316Y, 317T, 318S, 320I, 321D, 322E, 323L, 325F, 337L, 338A, 341H, 342Q, 343L, 345S, 346Y, 347K, 360H, 362H, 365S, 375R, 376S, 403D, 445K, 446L, 447G, 496I, 498E
CDD
cd00771 (ThrRS_core)

445K

dimer interface
248E, 254L, 256E, 257Y, 259P, 261F, 263F, 264F, 266P, 269M, 284E, 285K, 289Q, 290Q, 292E, 294P, 295I, 296M, 298N, 316Y, 317T, 318S, 320I, 321D, 322E, 323L, 325F, 337L, 338A, 341H, 342Q, 343L, 345S, 346Y, 347K, 360H, 362H, 365S, 375R, 376S, 403D, 445K, 446L, 447G, 496I, 498E
CDD
cd00771 (ThrRS_core)

446L

dimer interface
248E, 254L, 256E, 257Y, 259P, 261F, 263F, 264F, 266P, 269M, 284E, 285K, 289Q, 290Q, 292E, 294P, 295I, 296M, 298N, 316Y, 317T, 318S, 320I, 321D, 322E, 323L, 325F, 337L, 338A, 341H, 342Q, 343L, 345S, 346Y, 347K, 360H, 362H, 365S, 375R, 376S, 403D, 445K, 446L, 447G, 496I, 498E
CDD
cd00771 (ThrRS_core)

447G

dimer interface
248E, 254L, 256E, 257Y, 259P, 261F, 263F, 264F, 266P, 269M, 284E, 285K, 289Q, 290Q, 292E, 294P, 295I, 296M, 298N, 316Y, 317T, 318S, 320I, 321D, 322E, 323L, 325F, 337L, 338A, 341H, 342Q, 343L, 345S, 346Y, 347K, 360H, 362H, 365S, 375R, 376S, 403D, 445K, 446L, 447G, 496I, 498E
CDD
cd00771 (ThrRS_core)

496I

dimer interface
248E, 254L, 256E, 257Y, 259P, 261F, 263F, 264F, 266P, 269M, 284E, 285K, 289Q, 290Q, 292E, 294P, 295I, 296M, 298N, 316Y, 317T, 318S, 320I, 321D, 322E, 323L, 325F, 337L, 338A, 341H, 342Q, 343L, 345S, 346Y, 347K, 360H, 362H, 365S, 375R, 376S, 403D, 445K, 446L, 447G, 496I, 498E
CDD
cd00771 (ThrRS_core)

498E

dimer interface
248E, 254L, 256E, 257Y, 259P, 261F, 263F, 264F, 266P, 269M, 284E, 285K, 289Q, 290Q, 292E, 294P, 295I, 296M, 298N, 316Y, 317T, 318S, 320I, 321D, 322E, 323L, 325F, 337L, 338A, 341H, 342Q, 343L, 345S, 346Y, 347K, 360H, 362H, 365S, 375R, 376S, 403D, 445K, 446L, 447G, 496I, 498E
CDD
cd00771 (ThrRS_core)
motif 1 cd00771

289Q

motif 1
289Q, 290Q, 291L, 292E, 293T, 294P, 295I, 296M
CDD
cd00771 (ThrRS_core)

290Q

motif 1
289Q, 290Q, 291L, 292E, 293T, 294P, 295I, 296M
CDD
cd00771 (ThrRS_core)

291L

motif 1
289Q, 290Q, 291L, 292E, 293T, 294P, 295I, 296M
CDD
cd00771 (ThrRS_core)

292E

motif 1
289Q, 290Q, 291L, 292E, 293T, 294P, 295I, 296M
CDD
cd00771 (ThrRS_core)

293T

motif 1
289Q, 290Q, 291L, 292E, 293T, 294P, 295I, 296M
CDD
cd00771 (ThrRS_core)

294P

motif 1
289Q, 290Q, 291L, 292E, 293T, 294P, 295I, 296M
CDD
cd00771 (ThrRS_core)

295I

motif 1
289Q, 290Q, 291L, 292E, 293T, 294P, 295I, 296M
CDD
cd00771 (ThrRS_core)

296M

motif 1
289Q, 290Q, 291L, 292E, 293T, 294P, 295I, 296M
CDD
cd00771 (ThrRS_core)
motif 2 cd00771

360H

motif 2
360H, 361R, 362H, 363E
CDD
cd00771 (ThrRS_core)

361R

motif 2
360H, 361R, 362H, 363E
CDD
cd00771 (ThrRS_core)

362H

motif 2
360H, 361R, 362H, 363E
CDD
cd00771 (ThrRS_core)

363E

motif 2
360H, 361R, 362H, 363E
CDD
cd00771 (ThrRS_core)
motif 3 cd00771

514G

motif 3
514G, 515S, 516I, 517E, 518R
CDD
cd00771 (ThrRS_core)

515S

motif 3
514G, 515S, 516I, 517E, 518R
CDD
cd00771 (ThrRS_core)

516I

motif 3
514G, 515S, 516I, 517E, 518R
CDD
cd00771 (ThrRS_core)

517E

motif 3
514G, 515S, 516I, 517E, 518R
CDD
cd00771 (ThrRS_core)

518R

motif 3
514G, 515S, 516I, 517E, 518R
CDD
cd00771 (ThrRS_core)
anticodon binding ...

545L

anticodon binding site
545L, 546N, 581R, 588K, 596G, 606N, 608R
CDD
cd00860 (ThrRS_anticodon)

546N

anticodon binding site
545L, 546N, 581R, 588K, 596G, 606N, 608R
CDD
cd00860 (ThrRS_anticodon)

581R

anticodon binding site
545L, 546N, 581R, 588K, 596G, 606N, 608R
CDD
cd00860 (ThrRS_anticodon)

588K

anticodon binding site
545L, 546N, 581R, 588K, 596G, 606N, 608R
CDD
cd00860 (ThrRS_anticodon)

596G

anticodon binding site
545L, 546N, 581R, 588K, 596G, 606N, 608R
CDD
cd00860 (ThrRS_anticodon)

606N

anticodon binding site
545L, 546N, 581R, 588K, 596G, 606N, 608R
CDD
cd00860 (ThrRS_anticodon)

608R

anticodon binding site
545L, 546N, 581R, 588K, 596G, 606N, 608R
CDD
cd00860 (ThrRS_anticodon)

GO term prediction

Biological Process

GO:0006418 tRNA aminoacylation for protein translation
GO:0006435 threonyl-tRNA aminoacylation
GO:0043039 tRNA aminoacylation

Molecular Function

GO:0000166 nucleotide binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004829 threonine-tRNA ligase activity
GO:0005524 ATP binding

Cellular Component

GO:0005737 cytoplasm

Filter view on

Entry type

Status

Per-residue features

23726_FusoPortal_Gene_1783

Protein family membership

Homologous superfamilies

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component