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Entry type
Status
Per-residue features
Colour by
23726_FusoPortal_Gene_1951
Length
304 amino acids
Protein family membership
- Dihydroorotate dehydrogenase, class 1/ 2 (IPR012135)
- Dihydroorotate dehydrogenase, class 1 (IPR024920)
- Dihydroorotate dehydrogenase, class 1B (IPR033888)
- Dihydroorotate dehydrogenase, class 1 (IPR024920)
Homologous superfamilies
-
Homologous superfamily1 - 304
- Aldolase-type TIM barrel (IPR013785)
1
50
100
150
200
250
304
Domains and repeats
-
Domain5 - 303
- Dihydroorotate dehydrogenase domain (IPR005720)
1
50
100
150
200
250
304
Detailed signature matches
-
-
1 - 304
-
-
-
PIRSF000164 (DHO_ox...)1 - 304
-

Unintegrated signatures
-
PTHR43843 (FAMILY N...)6 - 302
-
PTHR43843:SF1 (DIHY...)6 - 302
-
SSF51395 (FMN-linke...)4 - 302
Residue annotation
-
heterodimer interf...30Eheterodimer interface
30E, 31Y, 34L, 46K, 54F, 60R, 61V, 63E, 75Q, 219P, 271T, 273P, 274F
CDD
cd04740 (DHOD_1B_like)31Yheterodimer interface
30E, 31Y, 34L, 46K, 54F, 60R, 61V, 63E, 75Q, 219P, 271T, 273P, 274F
CDD
cd04740 (DHOD_1B_like)34Lheterodimer interface
30E, 31Y, 34L, 46K, 54F, 60R, 61V, 63E, 75Q, 219P, 271T, 273P, 274F
CDD
cd04740 (DHOD_1B_like)46Kheterodimer interface
30E, 31Y, 34L, 46K, 54F, 60R, 61V, 63E, 75Q, 219P, 271T, 273P, 274F
CDD
cd04740 (DHOD_1B_like)54Fheterodimer interface
30E, 31Y, 34L, 46K, 54F, 60R, 61V, 63E, 75Q, 219P, 271T, 273P, 274F
CDD
cd04740 (DHOD_1B_like)60Rheterodimer interface
30E, 31Y, 34L, 46K, 54F, 60R, 61V, 63E, 75Q, 219P, 271T, 273P, 274F
CDD
cd04740 (DHOD_1B_like)61Vheterodimer interface
30E, 31Y, 34L, 46K, 54F, 60R, 61V, 63E, 75Q, 219P, 271T, 273P, 274F
CDD
cd04740 (DHOD_1B_like)63Eheterodimer interface
30E, 31Y, 34L, 46K, 54F, 60R, 61V, 63E, 75Q, 219P, 271T, 273P, 274F
CDD
cd04740 (DHOD_1B_like)75Qheterodimer interface
30E, 31Y, 34L, 46K, 54F, 60R, 61V, 63E, 75Q, 219P, 271T, 273P, 274F
CDD
cd04740 (DHOD_1B_like)219Pheterodimer interface
30E, 31Y, 34L, 46K, 54F, 60R, 61V, 63E, 75Q, 219P, 271T, 273P, 274F
CDD
cd04740 (DHOD_1B_like)271Theterodimer interface
30E, 31Y, 34L, 46K, 54F, 60R, 61V, 63E, 75Q, 219P, 271T, 273P, 274F
CDD
cd04740 (DHOD_1B_like)273Pheterodimer interface
30E, 31Y, 34L, 46K, 54F, 60R, 61V, 63E, 75Q, 219P, 271T, 273P, 274F
CDD
cd04740 (DHOD_1B_like)274Fheterodimer interface
30E, 31Y, 34L, 46K, 54F, 60R, 61V, 63E, 75Q, 219P, 271T, 273P, 274F
CDD
cd04740 (DHOD_1B_like) -
FMN binding site c...47AFMN binding site
47A, 70N, 128N, 166K, 192I, 193N, 218G, 245G, 266G, 267T
CDD
cd04740 (DHOD_1B_like)70NFMN binding site
47A, 70N, 128N, 166K, 192I, 193N, 218G, 245G, 266G, 267T
CDD
cd04740 (DHOD_1B_like)128NFMN binding site
47A, 70N, 128N, 166K, 192I, 193N, 218G, 245G, 266G, 267T
CDD
cd04740 (DHOD_1B_like)166KFMN binding site
47A, 70N, 128N, 166K, 192I, 193N, 218G, 245G, 266G, 267T
CDD
cd04740 (DHOD_1B_like)192IFMN binding site
47A, 70N, 128N, 166K, 192I, 193N, 218G, 245G, 266G, 267T
CDD
cd04740 (DHOD_1B_like)193NFMN binding site
47A, 70N, 128N, 166K, 192I, 193N, 218G, 245G, 266G, 267T
CDD
cd04740 (DHOD_1B_like)218GFMN binding site
47A, 70N, 128N, 166K, 192I, 193N, 218G, 245G, 266G, 267T
CDD
cd04740 (DHOD_1B_like)245GFMN binding site
47A, 70N, 128N, 166K, 192I, 193N, 218G, 245G, 266G, 267T
CDD
cd04740 (DHOD_1B_like)266GFMN binding site
47A, 70N, 128N, 166K, 192I, 193N, 218G, 245G, 266G, 267T
CDD
cd04740 (DHOD_1B_like)267TFMN binding site
47A, 70N, 128N, 166K, 192I, 193N, 218G, 245G, 266G, 267T
CDD
cd04740 (DHOD_1B_like) -
active site cd0474047Aactive site
47A, 70N, 128N, 131C, 166K, 192I, 193N, 194T, 218G, 245G, 266G, 267T
CDD
cd04740 (DHOD_1B_like)70Nactive site
47A, 70N, 128N, 131C, 166K, 192I, 193N, 194T, 218G, 245G, 266G, 267T
CDD
cd04740 (DHOD_1B_like)128Nactive site
47A, 70N, 128N, 131C, 166K, 192I, 193N, 194T, 218G, 245G, 266G, 267T
CDD
cd04740 (DHOD_1B_like)131Cactive site
47A, 70N, 128N, 131C, 166K, 192I, 193N, 194T, 218G, 245G, 266G, 267T
CDD
cd04740 (DHOD_1B_like)166Kactive site
47A, 70N, 128N, 131C, 166K, 192I, 193N, 194T, 218G, 245G, 266G, 267T
CDD
cd04740 (DHOD_1B_like)192Iactive site
47A, 70N, 128N, 131C, 166K, 192I, 193N, 194T, 218G, 245G, 266G, 267T
CDD
cd04740 (DHOD_1B_like)193Nactive site
47A, 70N, 128N, 131C, 166K, 192I, 193N, 194T, 218G, 245G, 266G, 267T
CDD
cd04740 (DHOD_1B_like)194Tactive site
47A, 70N, 128N, 131C, 166K, 192I, 193N, 194T, 218G, 245G, 266G, 267T
CDD
cd04740 (DHOD_1B_like)218Gactive site
47A, 70N, 128N, 131C, 166K, 192I, 193N, 194T, 218G, 245G, 266G, 267T
CDD
cd04740 (DHOD_1B_like)245Gactive site
47A, 70N, 128N, 131C, 166K, 192I, 193N, 194T, 218G, 245G, 266G, 267T
CDD
cd04740 (DHOD_1B_like)266Gactive site
47A, 70N, 128N, 131C, 166K, 192I, 193N, 194T, 218G, 245G, 266G, 267T
CDD
cd04740 (DHOD_1B_like)267Tactive site
47A, 70N, 128N, 131C, 166K, 192I, 193N, 194T, 218G, 245G, 266G, 267T
CDD
cd04740 (DHOD_1B_like) -
homodimer interfac...64Thomodimer interface
64T, 65S, 66S, 143T, 171V, 196V, 197G, 198I, 199V, 200L, 201D, 202R, 205G, 206K, 207P, 219P, 222K, 223P, 224V, 226I, 227R, 254D, 257S, 258A, 298L, 301R
CDD
cd04740 (DHOD_1B_like)65Shomodimer interface
64T, 65S, 66S, 143T, 171V, 196V, 197G, 198I, 199V, 200L, 201D, 202R, 205G, 206K, 207P, 219P, 222K, 223P, 224V, 226I, 227R, 254D, 257S, 258A, 298L, 301R
CDD
cd04740 (DHOD_1B_like)66Shomodimer interface
64T, 65S, 66S, 143T, 171V, 196V, 197G, 198I, 199V, 200L, 201D, 202R, 205G, 206K, 207P, 219P, 222K, 223P, 224V, 226I, 227R, 254D, 257S, 258A, 298L, 301R
CDD
cd04740 (DHOD_1B_like)143Thomodimer interface
64T, 65S, 66S, 143T, 171V, 196V, 197G, 198I, 199V, 200L, 201D, 202R, 205G, 206K, 207P, 219P, 222K, 223P, 224V, 226I, 227R, 254D, 257S, 258A, 298L, 301R
CDD
cd04740 (DHOD_1B_like)171Vhomodimer interface
64T, 65S, 66S, 143T, 171V, 196V, 197G, 198I, 199V, 200L, 201D, 202R, 205G, 206K, 207P, 219P, 222K, 223P, 224V, 226I, 227R, 254D, 257S, 258A, 298L, 301R
CDD
cd04740 (DHOD_1B_like)196Vhomodimer interface
64T, 65S, 66S, 143T, 171V, 196V, 197G, 198I, 199V, 200L, 201D, 202R, 205G, 206K, 207P, 219P, 222K, 223P, 224V, 226I, 227R, 254D, 257S, 258A, 298L, 301R
CDD
cd04740 (DHOD_1B_like)197Ghomodimer interface
64T, 65S, 66S, 143T, 171V, 196V, 197G, 198I, 199V, 200L, 201D, 202R, 205G, 206K, 207P, 219P, 222K, 223P, 224V, 226I, 227R, 254D, 257S, 258A, 298L, 301R
CDD
cd04740 (DHOD_1B_like)198Ihomodimer interface
64T, 65S, 66S, 143T, 171V, 196V, 197G, 198I, 199V, 200L, 201D, 202R, 205G, 206K, 207P, 219P, 222K, 223P, 224V, 226I, 227R, 254D, 257S, 258A, 298L, 301R
CDD
cd04740 (DHOD_1B_like)199Vhomodimer interface
64T, 65S, 66S, 143T, 171V, 196V, 197G, 198I, 199V, 200L, 201D, 202R, 205G, 206K, 207P, 219P, 222K, 223P, 224V, 226I, 227R, 254D, 257S, 258A, 298L, 301R
CDD
cd04740 (DHOD_1B_like)200Lhomodimer interface
64T, 65S, 66S, 143T, 171V, 196V, 197G, 198I, 199V, 200L, 201D, 202R, 205G, 206K, 207P, 219P, 222K, 223P, 224V, 226I, 227R, 254D, 257S, 258A, 298L, 301R
CDD
cd04740 (DHOD_1B_like)201Dhomodimer interface
64T, 65S, 66S, 143T, 171V, 196V, 197G, 198I, 199V, 200L, 201D, 202R, 205G, 206K, 207P, 219P, 222K, 223P, 224V, 226I, 227R, 254D, 257S, 258A, 298L, 301R
CDD
cd04740 (DHOD_1B_like)202Rhomodimer interface
64T, 65S, 66S, 143T, 171V, 196V, 197G, 198I, 199V, 200L, 201D, 202R, 205G, 206K, 207P, 219P, 222K, 223P, 224V, 226I, 227R, 254D, 257S, 258A, 298L, 301R
CDD
cd04740 (DHOD_1B_like)205Ghomodimer interface
64T, 65S, 66S, 143T, 171V, 196V, 197G, 198I, 199V, 200L, 201D, 202R, 205G, 206K, 207P, 219P, 222K, 223P, 224V, 226I, 227R, 254D, 257S, 258A, 298L, 301R
CDD
cd04740 (DHOD_1B_like)206Khomodimer interface
64T, 65S, 66S, 143T, 171V, 196V, 197G, 198I, 199V, 200L, 201D, 202R, 205G, 206K, 207P, 219P, 222K, 223P, 224V, 226I, 227R, 254D, 257S, 258A, 298L, 301R
CDD
cd04740 (DHOD_1B_like)207Phomodimer interface
64T, 65S, 66S, 143T, 171V, 196V, 197G, 198I, 199V, 200L, 201D, 202R, 205G, 206K, 207P, 219P, 222K, 223P, 224V, 226I, 227R, 254D, 257S, 258A, 298L, 301R
CDD
cd04740 (DHOD_1B_like)219Phomodimer interface
64T, 65S, 66S, 143T, 171V, 196V, 197G, 198I, 199V, 200L, 201D, 202R, 205G, 206K, 207P, 219P, 222K, 223P, 224V, 226I, 227R, 254D, 257S, 258A, 298L, 301R
CDD
cd04740 (DHOD_1B_like)222Khomodimer interface
64T, 65S, 66S, 143T, 171V, 196V, 197G, 198I, 199V, 200L, 201D, 202R, 205G, 206K, 207P, 219P, 222K, 223P, 224V, 226I, 227R, 254D, 257S, 258A, 298L, 301R
CDD
cd04740 (DHOD_1B_like)223Phomodimer interface
64T, 65S, 66S, 143T, 171V, 196V, 197G, 198I, 199V, 200L, 201D, 202R, 205G, 206K, 207P, 219P, 222K, 223P, 224V, 226I, 227R, 254D, 257S, 258A, 298L, 301R
CDD
cd04740 (DHOD_1B_like)224Vhomodimer interface
64T, 65S, 66S, 143T, 171V, 196V, 197G, 198I, 199V, 200L, 201D, 202R, 205G, 206K, 207P, 219P, 222K, 223P, 224V, 226I, 227R, 254D, 257S, 258A, 298L, 301R
CDD
cd04740 (DHOD_1B_like)226Ihomodimer interface
64T, 65S, 66S, 143T, 171V, 196V, 197G, 198I, 199V, 200L, 201D, 202R, 205G, 206K, 207P, 219P, 222K, 223P, 224V, 226I, 227R, 254D, 257S, 258A, 298L, 301R
CDD
cd04740 (DHOD_1B_like)227Rhomodimer interface
64T, 65S, 66S, 143T, 171V, 196V, 197G, 198I, 199V, 200L, 201D, 202R, 205G, 206K, 207P, 219P, 222K, 223P, 224V, 226I, 227R, 254D, 257S, 258A, 298L, 301R
CDD
cd04740 (DHOD_1B_like)254Dhomodimer interface
64T, 65S, 66S, 143T, 171V, 196V, 197G, 198I, 199V, 200L, 201D, 202R, 205G, 206K, 207P, 219P, 222K, 223P, 224V, 226I, 227R, 254D, 257S, 258A, 298L, 301R
CDD
cd04740 (DHOD_1B_like)257Shomodimer interface
64T, 65S, 66S, 143T, 171V, 196V, 197G, 198I, 199V, 200L, 201D, 202R, 205G, 206K, 207P, 219P, 222K, 223P, 224V, 226I, 227R, 254D, 257S, 258A, 298L, 301R
CDD
cd04740 (DHOD_1B_like)258Ahomodimer interface
64T, 65S, 66S, 143T, 171V, 196V, 197G, 198I, 199V, 200L, 201D, 202R, 205G, 206K, 207P, 219P, 222K, 223P, 224V, 226I, 227R, 254D, 257S, 258A, 298L, 301R
CDD
cd04740 (DHOD_1B_like)298Lhomodimer interface
64T, 65S, 66S, 143T, 171V, 196V, 197G, 198I, 199V, 200L, 201D, 202R, 205G, 206K, 207P, 219P, 222K, 223P, 224V, 226I, 227R, 254D, 257S, 258A, 298L, 301R
CDD
cd04740 (DHOD_1B_like)301Rhomodimer interface
64T, 65S, 66S, 143T, 171V, 196V, 197G, 198I, 199V, 200L, 201D, 202R, 205G, 206K, 207P, 219P, 222K, 223P, 224V, 226I, 227R, 254D, 257S, 258A, 298L, 301R
CDD
cd04740 (DHOD_1B_like) -
substrate binding ...70N128N130S193N194T
GO term prediction
Biological Process
GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process
GO:0006221 pyrimidine nucleotide biosynthetic process
GO:0006222 UMP biosynthetic process
GO:0055114 oxidation-reduction process
Molecular Function
GO:0003824 catalytic activity
GO:0004152 dihydroorotate dehydrogenase activity
GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors
Cellular Component
GO:0005737 cytoplasm