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Protein

23726_FusoPortal_Gene_202

Length

699 amino acids

Protein family membership

Polyribonucleotide nucleotidyltransferase (IPR012162)

Homologous superfamilies

Homologous superfamily
8 - 144
Ribosomal protein S5 domain 2-type fold (IPR020568)
303 - 497
Ribosomal protein S5 domain 2-type fold (IPR020568)
554 - 644
K Homology domain, type 1 superfamily (IPR036612)
Homologous superfamily
12 - 253
PNPase/RNase PH domain superfamily (IPR027408)
326 - 553
PNPase/RNase PH domain superfamily (IPR027408)
Homologous superfamily
138 - 230
Exoribonuclease, PH domain 2 superfamily (IPR036345)
254 - 325
Polyribonucleotide nucleotidyltransferase, RNA-binding domain superfamily (IPR036456)
459 - 555
Exoribonuclease, PH domain 2 superfamily (IPR036345)
616 - 698
Nucleic acid-binding, OB-fold (IPR012340)

1 100 200 300 400 500 600 699

Domains and repeats

Domain
14 - 144
Exoribonuclease, phosphorolytic domain 1 (IPR001247)
147 - 210
Exoribonuclease, phosphorolytic domain 2 (IPR015847)
243 - 329
Polyribonucleotide nucleotidyltransferase, RNA-binding domain (IPR015848)
332 - 465
Exoribonuclease, phosphorolytic domain 1 (IPR001247)
564 - 615
K Homology domain, type 1 (IPR004088)
628 - 697
S1 domain (IPR003029)

1 100 200 300 400 500 600 699

Detailed signature matches

IPR020568

Ribosomal protein S5 domain 2-type fold

SSF54211 (Ribosomal...)

303 - 497

SUPERFAMILY
SSF54211 (Ribosomal protein S5 domain 2-like)

8 - 144

SUPERFAMILY
SSF54211 (Ribosomal protein S5 domain 2-like)

IPR027408

PNPase/RNase PH domain superfamily

G3DSA:3.30.23...

326 - 553

GENE3D
G3DSA:3.30.230.70 (G3DSA:3.30.230.70)

12 - 253

GENE3D
G3DSA:3.30.230.70 (G3DSA:3.30.230.70)

IPR036345

Exoribonuclease, PH domain 2 superfamily

SSF55666 (Ribonucle...)

459 - 555

SUPERFAMILY
SSF55666 (Ribonuclease PH domain 2-like)

138 - 230

SUPERFAMILY
SSF55666 (Ribonuclease PH domain 2-like)

IPR036456

Polyribonucleotide nucleotidyltransferase, RNA-binding domain superfamily

G3DSA:1.10.10...

254 - 325

GENE3D
G3DSA:1.10.10.400 (G3DSA:1.10.10.400)

IPR036612

K Homology domain, type 1 superfamily

G3DSA:3.30.13...

554 - 625

GENE3D
G3DSA:3.30.1370.10 (G3DSA:3.30.1370.10)
SSF54791 (Eukaryoti...)

555 - 644

SUPERFAMILY
SSF54791 (Eukaryotic type KH-domain (KH-domain type I))

IPR012340

Nucleic acid-binding, OB-fold

SSF50249 (Nucleic a...)

616 - 698

SUPERFAMILY
SSF50249 (Nucleic acid-binding proteins)

IPR012162

Polyribonucleotide nucleotidyltransferase

TIGR03591

12 - 698

TIGRFAMs
TIGR03591 (TIGR03591)
PTHR11252 (POLYRIBO...)

4 - 698

PANTHER
PTHR11252 (POLYRIBONUCLEOTIDE NUCLEOTIDYLTRANSFERASE)
MF_01595 (PNPase)

3 - 699

HAMAP
MF_01595 (PNPase)
PIRSF005499 (PNPase)

1 - 699

PIRSF
PIRSF005499 (PNPase)

IPR001247

Exoribonuclease, phosphorolytic domain 1

PF01138 (RNase_PH)

332 - 465

Pfam
PF01138 (RNase_PH)

14 - 144

Pfam
PF01138 (RNase_PH)

IPR015847

Exoribonuclease, phosphorolytic domain 2

PF03725 (RNase_PH_C)

147 - 210

Pfam
PF03725 (RNase_PH_C)

IPR015848

Polyribonucleotide nucleotidyltransferase, RNA-binding domain

PF03726 (PNPase)

243 - 329

Pfam
PF03726 (PNPase)

IPR004088

K Homology domain, type 1

PF00013 (KH_1)

564 - 615

Pfam
PF00013 (KH_1)

IPR003029

S1 domain

PS50126 (S1)

630 - 697

PROSITE profiles
PS50126 (S1)
PF00575 (S1)

628 - 696

Pfam
PF00575 (S1)

no IPR

Unintegrated signatures

G3DSA:2.40.50...

630 - 699

GENE3D
G3DSA:2.40.50.140 (G3DSA:2.40.50.140)
PS50084 (KH_TYPE_1)

561 - 620

PROSITE profiles
PS50084 (KH_TYPE_1)
PTHR11252:SF0 (POLY...)

4 - 698

PANTHER
PTHR11252:SF0 (POLYRIBONUCLEOTIDE NUCLEOTIDYLTRANSFERASE 1, MITOCHONDRIAL)
cd02393 (PNPase_KH)

561 - 621

CDD
cd02393 (PNPase_KH)
cd04472 (S1_PNPase)

630 - 696

CDD
cd04472 (S1_PNPase)
cd11363 (RNase_PH_P...)

5 - 233

CDD
cd11363 (RNase_PH_PNPase_1)
cd11364 (RNase_PH_P...)

332 - 553

CDD
cd11364 (RNase_PH_PNPase_2)

Residue annotation

RNase E interface ...

6I

RNase E interface
6I, 8E, 17K, 19S, 22K, 32V, 34Q, 36G, 39V
CDD
cd11363 (RNase_PH_PNPase_1)

8E

RNase E interface
6I, 8E, 17K, 19S, 22K, 32V, 34Q, 36G, 39V
CDD
cd11363 (RNase_PH_PNPase_1)

17K

RNase E interface
6I, 8E, 17K, 19S, 22K, 32V, 34Q, 36G, 39V
CDD
cd11363 (RNase_PH_PNPase_1)

19S

RNase E interface
6I, 8E, 17K, 19S, 22K, 32V, 34Q, 36G, 39V
CDD
cd11363 (RNase_PH_PNPase_1)

22K

RNase E interface
6I, 8E, 17K, 19S, 22K, 32V, 34Q, 36G, 39V
CDD
cd11363 (RNase_PH_PNPase_1)

32V

RNase E interface
6I, 8E, 17K, 19S, 22K, 32V, 34Q, 36G, 39V
CDD
cd11363 (RNase_PH_PNPase_1)

34Q

RNase E interface
6I, 8E, 17K, 19S, 22K, 32V, 34Q, 36G, 39V
CDD
cd11363 (RNase_PH_PNPase_1)

36G

RNase E interface
6I, 8E, 17K, 19S, 22K, 32V, 34Q, 36G, 39V
CDD
cd11363 (RNase_PH_PNPase_1)

39V

RNase E interface
6I, 8E, 17K, 19S, 22K, 32V, 34Q, 36G, 39V
CDD
cd11363 (RNase_PH_PNPase_1)
trimer interface c...

22K

trimer interface
22K, 23I, 24S, 25R, 26Q, 27S, 32V, 41L, 43T, 45N, 47S, 62D, 64I, 66K, 67F, 68Y, 69S, 71G, 72K, 73F, 74P, 77F, 78N, 79K, 80R, 81E, 85S, 110D, 112H, 114V, 118L, 119S, 120Y, 121D, 122E
CDD
cd11363 (RNase_PH_PNPase_1)

23I

trimer interface
22K, 23I, 24S, 25R, 26Q, 27S, 32V, 41L, 43T, 45N, 47S, 62D, 64I, 66K, 67F, 68Y, 69S, 71G, 72K, 73F, 74P, 77F, 78N, 79K, 80R, 81E, 85S, 110D, 112H, 114V, 118L, 119S, 120Y, 121D, 122E
CDD
cd11363 (RNase_PH_PNPase_1)

24S

trimer interface
22K, 23I, 24S, 25R, 26Q, 27S, 32V, 41L, 43T, 45N, 47S, 62D, 64I, 66K, 67F, 68Y, 69S, 71G, 72K, 73F, 74P, 77F, 78N, 79K, 80R, 81E, 85S, 110D, 112H, 114V, 118L, 119S, 120Y, 121D, 122E
CDD
cd11363 (RNase_PH_PNPase_1)

25R

trimer interface
22K, 23I, 24S, 25R, 26Q, 27S, 32V, 41L, 43T, 45N, 47S, 62D, 64I, 66K, 67F, 68Y, 69S, 71G, 72K, 73F, 74P, 77F, 78N, 79K, 80R, 81E, 85S, 110D, 112H, 114V, 118L, 119S, 120Y, 121D, 122E
CDD
cd11363 (RNase_PH_PNPase_1)

26Q

trimer interface
22K, 23I, 24S, 25R, 26Q, 27S, 32V, 41L, 43T, 45N, 47S, 62D, 64I, 66K, 67F, 68Y, 69S, 71G, 72K, 73F, 74P, 77F, 78N, 79K, 80R, 81E, 85S, 110D, 112H, 114V, 118L, 119S, 120Y, 121D, 122E
CDD
cd11363 (RNase_PH_PNPase_1)

27S

trimer interface
22K, 23I, 24S, 25R, 26Q, 27S, 32V, 41L, 43T, 45N, 47S, 62D, 64I, 66K, 67F, 68Y, 69S, 71G, 72K, 73F, 74P, 77F, 78N, 79K, 80R, 81E, 85S, 110D, 112H, 114V, 118L, 119S, 120Y, 121D, 122E
CDD
cd11363 (RNase_PH_PNPase_1)

32V

trimer interface
22K, 23I, 24S, 25R, 26Q, 27S, 32V, 41L, 43T, 45N, 47S, 62D, 64I, 66K, 67F, 68Y, 69S, 71G, 72K, 73F, 74P, 77F, 78N, 79K, 80R, 81E, 85S, 110D, 112H, 114V, 118L, 119S, 120Y, 121D, 122E
CDD
cd11363 (RNase_PH_PNPase_1)

41L

trimer interface
22K, 23I, 24S, 25R, 26Q, 27S, 32V, 41L, 43T, 45N, 47S, 62D, 64I, 66K, 67F, 68Y, 69S, 71G, 72K, 73F, 74P, 77F, 78N, 79K, 80R, 81E, 85S, 110D, 112H, 114V, 118L, 119S, 120Y, 121D, 122E
CDD
cd11363 (RNase_PH_PNPase_1)

43T

trimer interface
22K, 23I, 24S, 25R, 26Q, 27S, 32V, 41L, 43T, 45N, 47S, 62D, 64I, 66K, 67F, 68Y, 69S, 71G, 72K, 73F, 74P, 77F, 78N, 79K, 80R, 81E, 85S, 110D, 112H, 114V, 118L, 119S, 120Y, 121D, 122E
CDD
cd11363 (RNase_PH_PNPase_1)

45N

trimer interface
22K, 23I, 24S, 25R, 26Q, 27S, 32V, 41L, 43T, 45N, 47S, 62D, 64I, 66K, 67F, 68Y, 69S, 71G, 72K, 73F, 74P, 77F, 78N, 79K, 80R, 81E, 85S, 110D, 112H, 114V, 118L, 119S, 120Y, 121D, 122E
CDD
cd11363 (RNase_PH_PNPase_1)

47S

trimer interface
22K, 23I, 24S, 25R, 26Q, 27S, 32V, 41L, 43T, 45N, 47S, 62D, 64I, 66K, 67F, 68Y, 69S, 71G, 72K, 73F, 74P, 77F, 78N, 79K, 80R, 81E, 85S, 110D, 112H, 114V, 118L, 119S, 120Y, 121D, 122E
CDD
cd11363 (RNase_PH_PNPase_1)

62D

trimer interface
22K, 23I, 24S, 25R, 26Q, 27S, 32V, 41L, 43T, 45N, 47S, 62D, 64I, 66K, 67F, 68Y, 69S, 71G, 72K, 73F, 74P, 77F, 78N, 79K, 80R, 81E, 85S, 110D, 112H, 114V, 118L, 119S, 120Y, 121D, 122E
CDD
cd11363 (RNase_PH_PNPase_1)

64I

trimer interface
22K, 23I, 24S, 25R, 26Q, 27S, 32V, 41L, 43T, 45N, 47S, 62D, 64I, 66K, 67F, 68Y, 69S, 71G, 72K, 73F, 74P, 77F, 78N, 79K, 80R, 81E, 85S, 110D, 112H, 114V, 118L, 119S, 120Y, 121D, 122E
CDD
cd11363 (RNase_PH_PNPase_1)

66K

trimer interface
22K, 23I, 24S, 25R, 26Q, 27S, 32V, 41L, 43T, 45N, 47S, 62D, 64I, 66K, 67F, 68Y, 69S, 71G, 72K, 73F, 74P, 77F, 78N, 79K, 80R, 81E, 85S, 110D, 112H, 114V, 118L, 119S, 120Y, 121D, 122E
CDD
cd11363 (RNase_PH_PNPase_1)

67F

trimer interface
22K, 23I, 24S, 25R, 26Q, 27S, 32V, 41L, 43T, 45N, 47S, 62D, 64I, 66K, 67F, 68Y, 69S, 71G, 72K, 73F, 74P, 77F, 78N, 79K, 80R, 81E, 85S, 110D, 112H, 114V, 118L, 119S, 120Y, 121D, 122E
CDD
cd11363 (RNase_PH_PNPase_1)

68Y

trimer interface
22K, 23I, 24S, 25R, 26Q, 27S, 32V, 41L, 43T, 45N, 47S, 62D, 64I, 66K, 67F, 68Y, 69S, 71G, 72K, 73F, 74P, 77F, 78N, 79K, 80R, 81E, 85S, 110D, 112H, 114V, 118L, 119S, 120Y, 121D, 122E
CDD
cd11363 (RNase_PH_PNPase_1)

69S

trimer interface
22K, 23I, 24S, 25R, 26Q, 27S, 32V, 41L, 43T, 45N, 47S, 62D, 64I, 66K, 67F, 68Y, 69S, 71G, 72K, 73F, 74P, 77F, 78N, 79K, 80R, 81E, 85S, 110D, 112H, 114V, 118L, 119S, 120Y, 121D, 122E
CDD
cd11363 (RNase_PH_PNPase_1)

71G

trimer interface
22K, 23I, 24S, 25R, 26Q, 27S, 32V, 41L, 43T, 45N, 47S, 62D, 64I, 66K, 67F, 68Y, 69S, 71G, 72K, 73F, 74P, 77F, 78N, 79K, 80R, 81E, 85S, 110D, 112H, 114V, 118L, 119S, 120Y, 121D, 122E
CDD
cd11363 (RNase_PH_PNPase_1)

72K

trimer interface
22K, 23I, 24S, 25R, 26Q, 27S, 32V, 41L, 43T, 45N, 47S, 62D, 64I, 66K, 67F, 68Y, 69S, 71G, 72K, 73F, 74P, 77F, 78N, 79K, 80R, 81E, 85S, 110D, 112H, 114V, 118L, 119S, 120Y, 121D, 122E
CDD
cd11363 (RNase_PH_PNPase_1)

73F

trimer interface
22K, 23I, 24S, 25R, 26Q, 27S, 32V, 41L, 43T, 45N, 47S, 62D, 64I, 66K, 67F, 68Y, 69S, 71G, 72K, 73F, 74P, 77F, 78N, 79K, 80R, 81E, 85S, 110D, 112H, 114V, 118L, 119S, 120Y, 121D, 122E
CDD
cd11363 (RNase_PH_PNPase_1)

74P

trimer interface
22K, 23I, 24S, 25R, 26Q, 27S, 32V, 41L, 43T, 45N, 47S, 62D, 64I, 66K, 67F, 68Y, 69S, 71G, 72K, 73F, 74P, 77F, 78N, 79K, 80R, 81E, 85S, 110D, 112H, 114V, 118L, 119S, 120Y, 121D, 122E
CDD
cd11363 (RNase_PH_PNPase_1)

77F

trimer interface
22K, 23I, 24S, 25R, 26Q, 27S, 32V, 41L, 43T, 45N, 47S, 62D, 64I, 66K, 67F, 68Y, 69S, 71G, 72K, 73F, 74P, 77F, 78N, 79K, 80R, 81E, 85S, 110D, 112H, 114V, 118L, 119S, 120Y, 121D, 122E
CDD
cd11363 (RNase_PH_PNPase_1)

78N

trimer interface
22K, 23I, 24S, 25R, 26Q, 27S, 32V, 41L, 43T, 45N, 47S, 62D, 64I, 66K, 67F, 68Y, 69S, 71G, 72K, 73F, 74P, 77F, 78N, 79K, 80R, 81E, 85S, 110D, 112H, 114V, 118L, 119S, 120Y, 121D, 122E
CDD
cd11363 (RNase_PH_PNPase_1)

79K

trimer interface
22K, 23I, 24S, 25R, 26Q, 27S, 32V, 41L, 43T, 45N, 47S, 62D, 64I, 66K, 67F, 68Y, 69S, 71G, 72K, 73F, 74P, 77F, 78N, 79K, 80R, 81E, 85S, 110D, 112H, 114V, 118L, 119S, 120Y, 121D, 122E
CDD
cd11363 (RNase_PH_PNPase_1)

80R

trimer interface
22K, 23I, 24S, 25R, 26Q, 27S, 32V, 41L, 43T, 45N, 47S, 62D, 64I, 66K, 67F, 68Y, 69S, 71G, 72K, 73F, 74P, 77F, 78N, 79K, 80R, 81E, 85S, 110D, 112H, 114V, 118L, 119S, 120Y, 121D, 122E
CDD
cd11363 (RNase_PH_PNPase_1)

81E

trimer interface
22K, 23I, 24S, 25R, 26Q, 27S, 32V, 41L, 43T, 45N, 47S, 62D, 64I, 66K, 67F, 68Y, 69S, 71G, 72K, 73F, 74P, 77F, 78N, 79K, 80R, 81E, 85S, 110D, 112H, 114V, 118L, 119S, 120Y, 121D, 122E
CDD
cd11363 (RNase_PH_PNPase_1)

85S

trimer interface
22K, 23I, 24S, 25R, 26Q, 27S, 32V, 41L, 43T, 45N, 47S, 62D, 64I, 66K, 67F, 68Y, 69S, 71G, 72K, 73F, 74P, 77F, 78N, 79K, 80R, 81E, 85S, 110D, 112H, 114V, 118L, 119S, 120Y, 121D, 122E
CDD
cd11363 (RNase_PH_PNPase_1)

110D

trimer interface
22K, 23I, 24S, 25R, 26Q, 27S, 32V, 41L, 43T, 45N, 47S, 62D, 64I, 66K, 67F, 68Y, 69S, 71G, 72K, 73F, 74P, 77F, 78N, 79K, 80R, 81E, 85S, 110D, 112H, 114V, 118L, 119S, 120Y, 121D, 122E
CDD
cd11363 (RNase_PH_PNPase_1)

112H

trimer interface
22K, 23I, 24S, 25R, 26Q, 27S, 32V, 41L, 43T, 45N, 47S, 62D, 64I, 66K, 67F, 68Y, 69S, 71G, 72K, 73F, 74P, 77F, 78N, 79K, 80R, 81E, 85S, 110D, 112H, 114V, 118L, 119S, 120Y, 121D, 122E
CDD
cd11363 (RNase_PH_PNPase_1)

114V

trimer interface
22K, 23I, 24S, 25R, 26Q, 27S, 32V, 41L, 43T, 45N, 47S, 62D, 64I, 66K, 67F, 68Y, 69S, 71G, 72K, 73F, 74P, 77F, 78N, 79K, 80R, 81E, 85S, 110D, 112H, 114V, 118L, 119S, 120Y, 121D, 122E
CDD
cd11363 (RNase_PH_PNPase_1)

118L

trimer interface
22K, 23I, 24S, 25R, 26Q, 27S, 32V, 41L, 43T, 45N, 47S, 62D, 64I, 66K, 67F, 68Y, 69S, 71G, 72K, 73F, 74P, 77F, 78N, 79K, 80R, 81E, 85S, 110D, 112H, 114V, 118L, 119S, 120Y, 121D, 122E
CDD
cd11363 (RNase_PH_PNPase_1)

119S

trimer interface
22K, 23I, 24S, 25R, 26Q, 27S, 32V, 41L, 43T, 45N, 47S, 62D, 64I, 66K, 67F, 68Y, 69S, 71G, 72K, 73F, 74P, 77F, 78N, 79K, 80R, 81E, 85S, 110D, 112H, 114V, 118L, 119S, 120Y, 121D, 122E
CDD
cd11363 (RNase_PH_PNPase_1)

120Y

trimer interface
22K, 23I, 24S, 25R, 26Q, 27S, 32V, 41L, 43T, 45N, 47S, 62D, 64I, 66K, 67F, 68Y, 69S, 71G, 72K, 73F, 74P, 77F, 78N, 79K, 80R, 81E, 85S, 110D, 112H, 114V, 118L, 119S, 120Y, 121D, 122E
CDD
cd11363 (RNase_PH_PNPase_1)

121D

trimer interface
22K, 23I, 24S, 25R, 26Q, 27S, 32V, 41L, 43T, 45N, 47S, 62D, 64I, 66K, 67F, 68Y, 69S, 71G, 72K, 73F, 74P, 77F, 78N, 79K, 80R, 81E, 85S, 110D, 112H, 114V, 118L, 119S, 120Y, 121D, 122E
CDD
cd11363 (RNase_PH_PNPase_1)

122E

trimer interface
22K, 23I, 24S, 25R, 26Q, 27S, 32V, 41L, 43T, 45N, 47S, 62D, 64I, 66K, 67F, 68Y, 69S, 71G, 72K, 73F, 74P, 77F, 78N, 79K, 80R, 81E, 85S, 110D, 112H, 114V, 118L, 119S, 120Y, 121D, 122E
CDD
cd11363 (RNase_PH_PNPase_1)
RNase E interface ...

332E

RNase E interface
332E, 333I, 334R, 335P, 336L, 337D, 338A, 339Q, 340I, 341N, 344P, 537Q, 541Q, 545L, 549T, 550I
CDD
cd11364 (RNase_PH_PNPase_2)

333I

RNase E interface
332E, 333I, 334R, 335P, 336L, 337D, 338A, 339Q, 340I, 341N, 344P, 537Q, 541Q, 545L, 549T, 550I
CDD
cd11364 (RNase_PH_PNPase_2)

334R

RNase E interface
332E, 333I, 334R, 335P, 336L, 337D, 338A, 339Q, 340I, 341N, 344P, 537Q, 541Q, 545L, 549T, 550I
CDD
cd11364 (RNase_PH_PNPase_2)

335P

RNase E interface
332E, 333I, 334R, 335P, 336L, 337D, 338A, 339Q, 340I, 341N, 344P, 537Q, 541Q, 545L, 549T, 550I
CDD
cd11364 (RNase_PH_PNPase_2)

336L

RNase E interface
332E, 333I, 334R, 335P, 336L, 337D, 338A, 339Q, 340I, 341N, 344P, 537Q, 541Q, 545L, 549T, 550I
CDD
cd11364 (RNase_PH_PNPase_2)

337D

RNase E interface
332E, 333I, 334R, 335P, 336L, 337D, 338A, 339Q, 340I, 341N, 344P, 537Q, 541Q, 545L, 549T, 550I
CDD
cd11364 (RNase_PH_PNPase_2)

338A

RNase E interface
332E, 333I, 334R, 335P, 336L, 337D, 338A, 339Q, 340I, 341N, 344P, 537Q, 541Q, 545L, 549T, 550I
CDD
cd11364 (RNase_PH_PNPase_2)

339Q

RNase E interface
332E, 333I, 334R, 335P, 336L, 337D, 338A, 339Q, 340I, 341N, 344P, 537Q, 541Q, 545L, 549T, 550I
CDD
cd11364 (RNase_PH_PNPase_2)

340I

RNase E interface
332E, 333I, 334R, 335P, 336L, 337D, 338A, 339Q, 340I, 341N, 344P, 537Q, 541Q, 545L, 549T, 550I
CDD
cd11364 (RNase_PH_PNPase_2)

341N

RNase E interface
332E, 333I, 334R, 335P, 336L, 337D, 338A, 339Q, 340I, 341N, 344P, 537Q, 541Q, 545L, 549T, 550I
CDD
cd11364 (RNase_PH_PNPase_2)

344P

RNase E interface
332E, 333I, 334R, 335P, 336L, 337D, 338A, 339Q, 340I, 341N, 344P, 537Q, 541Q, 545L, 549T, 550I
CDD
cd11364 (RNase_PH_PNPase_2)

537Q

RNase E interface
332E, 333I, 334R, 335P, 336L, 337D, 338A, 339Q, 340I, 341N, 344P, 537Q, 541Q, 545L, 549T, 550I
CDD
cd11364 (RNase_PH_PNPase_2)

541Q

RNase E interface
332E, 333I, 334R, 335P, 336L, 337D, 338A, 339Q, 340I, 341N, 344P, 537Q, 541Q, 545L, 549T, 550I
CDD
cd11364 (RNase_PH_PNPase_2)

545L

RNase E interface
332E, 333I, 334R, 335P, 336L, 337D, 338A, 339Q, 340I, 341N, 344P, 537Q, 541Q, 545L, 549T, 550I
CDD
cd11364 (RNase_PH_PNPase_2)

549T

RNase E interface
332E, 333I, 334R, 335P, 336L, 337D, 338A, 339Q, 340I, 341N, 344P, 537Q, 541Q, 545L, 549T, 550I
CDD
cd11364 (RNase_PH_PNPase_2)

550I

RNase E interface
332E, 333I, 334R, 335P, 336L, 337D, 338A, 339Q, 340I, 341N, 344P, 537Q, 541Q, 545L, 549T, 550I
CDD
cd11364 (RNase_PH_PNPase_2)
trimer interface c...

337D

trimer interface
337D, 339Q, 343L, 344P, 345I, 346P, 347H, 355G, 356E, 360L, 362I, 364T, 365L, 366G, 370D, 371E, 372Q, 388H, 390N, 393P, 394Y, 395S, 396V, 398E, 399V, 400G, 403G, 405P, 435R, 437V, 439E, 441T, 442E, 443S
CDD
cd11364 (RNase_PH_PNPase_2)

339Q

trimer interface
337D, 339Q, 343L, 344P, 345I, 346P, 347H, 355G, 356E, 360L, 362I, 364T, 365L, 366G, 370D, 371E, 372Q, 388H, 390N, 393P, 394Y, 395S, 396V, 398E, 399V, 400G, 403G, 405P, 435R, 437V, 439E, 441T, 442E, 443S
CDD
cd11364 (RNase_PH_PNPase_2)

343L

trimer interface
337D, 339Q, 343L, 344P, 345I, 346P, 347H, 355G, 356E, 360L, 362I, 364T, 365L, 366G, 370D, 371E, 372Q, 388H, 390N, 393P, 394Y, 395S, 396V, 398E, 399V, 400G, 403G, 405P, 435R, 437V, 439E, 441T, 442E, 443S
CDD
cd11364 (RNase_PH_PNPase_2)

344P

trimer interface
337D, 339Q, 343L, 344P, 345I, 346P, 347H, 355G, 356E, 360L, 362I, 364T, 365L, 366G, 370D, 371E, 372Q, 388H, 390N, 393P, 394Y, 395S, 396V, 398E, 399V, 400G, 403G, 405P, 435R, 437V, 439E, 441T, 442E, 443S
CDD
cd11364 (RNase_PH_PNPase_2)

345I

trimer interface
337D, 339Q, 343L, 344P, 345I, 346P, 347H, 355G, 356E, 360L, 362I, 364T, 365L, 366G, 370D, 371E, 372Q, 388H, 390N, 393P, 394Y, 395S, 396V, 398E, 399V, 400G, 403G, 405P, 435R, 437V, 439E, 441T, 442E, 443S
CDD
cd11364 (RNase_PH_PNPase_2)

346P

trimer interface
337D, 339Q, 343L, 344P, 345I, 346P, 347H, 355G, 356E, 360L, 362I, 364T, 365L, 366G, 370D, 371E, 372Q, 388H, 390N, 393P, 394Y, 395S, 396V, 398E, 399V, 400G, 403G, 405P, 435R, 437V, 439E, 441T, 442E, 443S
CDD
cd11364 (RNase_PH_PNPase_2)

347H

trimer interface
337D, 339Q, 343L, 344P, 345I, 346P, 347H, 355G, 356E, 360L, 362I, 364T, 365L, 366G, 370D, 371E, 372Q, 388H, 390N, 393P, 394Y, 395S, 396V, 398E, 399V, 400G, 403G, 405P, 435R, 437V, 439E, 441T, 442E, 443S
CDD
cd11364 (RNase_PH_PNPase_2)

355G

trimer interface
337D, 339Q, 343L, 344P, 345I, 346P, 347H, 355G, 356E, 360L, 362I, 364T, 365L, 366G, 370D, 371E, 372Q, 388H, 390N, 393P, 394Y, 395S, 396V, 398E, 399V, 400G, 403G, 405P, 435R, 437V, 439E, 441T, 442E, 443S
CDD
cd11364 (RNase_PH_PNPase_2)

356E

trimer interface
337D, 339Q, 343L, 344P, 345I, 346P, 347H, 355G, 356E, 360L, 362I, 364T, 365L, 366G, 370D, 371E, 372Q, 388H, 390N, 393P, 394Y, 395S, 396V, 398E, 399V, 400G, 403G, 405P, 435R, 437V, 439E, 441T, 442E, 443S
CDD
cd11364 (RNase_PH_PNPase_2)

360L

trimer interface
337D, 339Q, 343L, 344P, 345I, 346P, 347H, 355G, 356E, 360L, 362I, 364T, 365L, 366G, 370D, 371E, 372Q, 388H, 390N, 393P, 394Y, 395S, 396V, 398E, 399V, 400G, 403G, 405P, 435R, 437V, 439E, 441T, 442E, 443S
CDD
cd11364 (RNase_PH_PNPase_2)

362I

trimer interface
337D, 339Q, 343L, 344P, 345I, 346P, 347H, 355G, 356E, 360L, 362I, 364T, 365L, 366G, 370D, 371E, 372Q, 388H, 390N, 393P, 394Y, 395S, 396V, 398E, 399V, 400G, 403G, 405P, 435R, 437V, 439E, 441T, 442E, 443S
CDD
cd11364 (RNase_PH_PNPase_2)

364T

trimer interface
337D, 339Q, 343L, 344P, 345I, 346P, 347H, 355G, 356E, 360L, 362I, 364T, 365L, 366G, 370D, 371E, 372Q, 388H, 390N, 393P, 394Y, 395S, 396V, 398E, 399V, 400G, 403G, 405P, 435R, 437V, 439E, 441T, 442E, 443S
CDD
cd11364 (RNase_PH_PNPase_2)

365L

trimer interface
337D, 339Q, 343L, 344P, 345I, 346P, 347H, 355G, 356E, 360L, 362I, 364T, 365L, 366G, 370D, 371E, 372Q, 388H, 390N, 393P, 394Y, 395S, 396V, 398E, 399V, 400G, 403G, 405P, 435R, 437V, 439E, 441T, 442E, 443S
CDD
cd11364 (RNase_PH_PNPase_2)

366G

trimer interface
337D, 339Q, 343L, 344P, 345I, 346P, 347H, 355G, 356E, 360L, 362I, 364T, 365L, 366G, 370D, 371E, 372Q, 388H, 390N, 393P, 394Y, 395S, 396V, 398E, 399V, 400G, 403G, 405P, 435R, 437V, 439E, 441T, 442E, 443S
CDD
cd11364 (RNase_PH_PNPase_2)

370D

trimer interface
337D, 339Q, 343L, 344P, 345I, 346P, 347H, 355G, 356E, 360L, 362I, 364T, 365L, 366G, 370D, 371E, 372Q, 388H, 390N, 393P, 394Y, 395S, 396V, 398E, 399V, 400G, 403G, 405P, 435R, 437V, 439E, 441T, 442E, 443S
CDD
cd11364 (RNase_PH_PNPase_2)

371E

trimer interface
337D, 339Q, 343L, 344P, 345I, 346P, 347H, 355G, 356E, 360L, 362I, 364T, 365L, 366G, 370D, 371E, 372Q, 388H, 390N, 393P, 394Y, 395S, 396V, 398E, 399V, 400G, 403G, 405P, 435R, 437V, 439E, 441T, 442E, 443S
CDD
cd11364 (RNase_PH_PNPase_2)

372Q

trimer interface
337D, 339Q, 343L, 344P, 345I, 346P, 347H, 355G, 356E, 360L, 362I, 364T, 365L, 366G, 370D, 371E, 372Q, 388H, 390N, 393P, 394Y, 395S, 396V, 398E, 399V, 400G, 403G, 405P, 435R, 437V, 439E, 441T, 442E, 443S
CDD
cd11364 (RNase_PH_PNPase_2)

388H

trimer interface
337D, 339Q, 343L, 344P, 345I, 346P, 347H, 355G, 356E, 360L, 362I, 364T, 365L, 366G, 370D, 371E, 372Q, 388H, 390N, 393P, 394Y, 395S, 396V, 398E, 399V, 400G, 403G, 405P, 435R, 437V, 439E, 441T, 442E, 443S
CDD
cd11364 (RNase_PH_PNPase_2)

390N

trimer interface
337D, 339Q, 343L, 344P, 345I, 346P, 347H, 355G, 356E, 360L, 362I, 364T, 365L, 366G, 370D, 371E, 372Q, 388H, 390N, 393P, 394Y, 395S, 396V, 398E, 399V, 400G, 403G, 405P, 435R, 437V, 439E, 441T, 442E, 443S
CDD
cd11364 (RNase_PH_PNPase_2)

393P

trimer interface
337D, 339Q, 343L, 344P, 345I, 346P, 347H, 355G, 356E, 360L, 362I, 364T, 365L, 366G, 370D, 371E, 372Q, 388H, 390N, 393P, 394Y, 395S, 396V, 398E, 399V, 400G, 403G, 405P, 435R, 437V, 439E, 441T, 442E, 443S
CDD
cd11364 (RNase_PH_PNPase_2)

394Y

trimer interface
337D, 339Q, 343L, 344P, 345I, 346P, 347H, 355G, 356E, 360L, 362I, 364T, 365L, 366G, 370D, 371E, 372Q, 388H, 390N, 393P, 394Y, 395S, 396V, 398E, 399V, 400G, 403G, 405P, 435R, 437V, 439E, 441T, 442E, 443S
CDD
cd11364 (RNase_PH_PNPase_2)

395S

trimer interface
337D, 339Q, 343L, 344P, 345I, 346P, 347H, 355G, 356E, 360L, 362I, 364T, 365L, 366G, 370D, 371E, 372Q, 388H, 390N, 393P, 394Y, 395S, 396V, 398E, 399V, 400G, 403G, 405P, 435R, 437V, 439E, 441T, 442E, 443S
CDD
cd11364 (RNase_PH_PNPase_2)

396V

trimer interface
337D, 339Q, 343L, 344P, 345I, 346P, 347H, 355G, 356E, 360L, 362I, 364T, 365L, 366G, 370D, 371E, 372Q, 388H, 390N, 393P, 394Y, 395S, 396V, 398E, 399V, 400G, 403G, 405P, 435R, 437V, 439E, 441T, 442E, 443S
CDD
cd11364 (RNase_PH_PNPase_2)

398E

trimer interface
337D, 339Q, 343L, 344P, 345I, 346P, 347H, 355G, 356E, 360L, 362I, 364T, 365L, 366G, 370D, 371E, 372Q, 388H, 390N, 393P, 394Y, 395S, 396V, 398E, 399V, 400G, 403G, 405P, 435R, 437V, 439E, 441T, 442E, 443S
CDD
cd11364 (RNase_PH_PNPase_2)

399V

trimer interface
337D, 339Q, 343L, 344P, 345I, 346P, 347H, 355G, 356E, 360L, 362I, 364T, 365L, 366G, 370D, 371E, 372Q, 388H, 390N, 393P, 394Y, 395S, 396V, 398E, 399V, 400G, 403G, 405P, 435R, 437V, 439E, 441T, 442E, 443S
CDD
cd11364 (RNase_PH_PNPase_2)

400G

trimer interface
337D, 339Q, 343L, 344P, 345I, 346P, 347H, 355G, 356E, 360L, 362I, 364T, 365L, 366G, 370D, 371E, 372Q, 388H, 390N, 393P, 394Y, 395S, 396V, 398E, 399V, 400G, 403G, 405P, 435R, 437V, 439E, 441T, 442E, 443S
CDD
cd11364 (RNase_PH_PNPase_2)

403G

trimer interface
337D, 339Q, 343L, 344P, 345I, 346P, 347H, 355G, 356E, 360L, 362I, 364T, 365L, 366G, 370D, 371E, 372Q, 388H, 390N, 393P, 394Y, 395S, 396V, 398E, 399V, 400G, 403G, 405P, 435R, 437V, 439E, 441T, 442E, 443S
CDD
cd11364 (RNase_PH_PNPase_2)

405P

trimer interface
337D, 339Q, 343L, 344P, 345I, 346P, 347H, 355G, 356E, 360L, 362I, 364T, 365L, 366G, 370D, 371E, 372Q, 388H, 390N, 393P, 394Y, 395S, 396V, 398E, 399V, 400G, 403G, 405P, 435R, 437V, 439E, 441T, 442E, 443S
CDD
cd11364 (RNase_PH_PNPase_2)

435R

trimer interface
337D, 339Q, 343L, 344P, 345I, 346P, 347H, 355G, 356E, 360L, 362I, 364T, 365L, 366G, 370D, 371E, 372Q, 388H, 390N, 393P, 394Y, 395S, 396V, 398E, 399V, 400G, 403G, 405P, 435R, 437V, 439E, 441T, 442E, 443S
CDD
cd11364 (RNase_PH_PNPase_2)

437V

trimer interface
337D, 339Q, 343L, 344P, 345I, 346P, 347H, 355G, 356E, 360L, 362I, 364T, 365L, 366G, 370D, 371E, 372Q, 388H, 390N, 393P, 394Y, 395S, 396V, 398E, 399V, 400G, 403G, 405P, 435R, 437V, 439E, 441T, 442E, 443S
CDD
cd11364 (RNase_PH_PNPase_2)

439E

trimer interface
337D, 339Q, 343L, 344P, 345I, 346P, 347H, 355G, 356E, 360L, 362I, 364T, 365L, 366G, 370D, 371E, 372Q, 388H, 390N, 393P, 394Y, 395S, 396V, 398E, 399V, 400G, 403G, 405P, 435R, 437V, 439E, 441T, 442E, 443S
CDD
cd11364 (RNase_PH_PNPase_2)

441T

trimer interface
337D, 339Q, 343L, 344P, 345I, 346P, 347H, 355G, 356E, 360L, 362I, 364T, 365L, 366G, 370D, 371E, 372Q, 388H, 390N, 393P, 394Y, 395S, 396V, 398E, 399V, 400G, 403G, 405P, 435R, 437V, 439E, 441T, 442E, 443S
CDD
cd11364 (RNase_PH_PNPase_2)

442E

trimer interface
337D, 339Q, 343L, 344P, 345I, 346P, 347H, 355G, 356E, 360L, 362I, 364T, 365L, 366G, 370D, 371E, 372Q, 388H, 390N, 393P, 394Y, 395S, 396V, 398E, 399V, 400G, 403G, 405P, 435R, 437V, 439E, 441T, 442E, 443S
CDD
cd11364 (RNase_PH_PNPase_2)

443S

trimer interface
337D, 339Q, 343L, 344P, 345I, 346P, 347H, 355G, 356E, 360L, 362I, 364T, 365L, 366G, 370D, 371E, 372Q, 388H, 390N, 393P, 394Y, 395S, 396V, 398E, 399V, 400G, 403G, 405P, 435R, 437V, 439E, 441T, 442E, 443S
CDD
cd11364 (RNase_PH_PNPase_2)
active site cd11364

389Y

active site
389Y, 391F, 408R, 412H, 446S, 447S, 448S, 495D, 501D, 503K, 515Q, 517D
CDD
cd11364 (RNase_PH_PNPase_2)

391F

active site
389Y, 391F, 408R, 412H, 446S, 447S, 448S, 495D, 501D, 503K, 515Q, 517D
CDD
cd11364 (RNase_PH_PNPase_2)

408R

active site
389Y, 391F, 408R, 412H, 446S, 447S, 448S, 495D, 501D, 503K, 515Q, 517D
CDD
cd11364 (RNase_PH_PNPase_2)

412H

active site
389Y, 391F, 408R, 412H, 446S, 447S, 448S, 495D, 501D, 503K, 515Q, 517D
CDD
cd11364 (RNase_PH_PNPase_2)

446S

active site
389Y, 391F, 408R, 412H, 446S, 447S, 448S, 495D, 501D, 503K, 515Q, 517D
CDD
cd11364 (RNase_PH_PNPase_2)

447S

active site
389Y, 391F, 408R, 412H, 446S, 447S, 448S, 495D, 501D, 503K, 515Q, 517D
CDD
cd11364 (RNase_PH_PNPase_2)

448S

active site
389Y, 391F, 408R, 412H, 446S, 447S, 448S, 495D, 501D, 503K, 515Q, 517D
CDD
cd11364 (RNase_PH_PNPase_2)

495D

active site
389Y, 391F, 408R, 412H, 446S, 447S, 448S, 495D, 501D, 503K, 515Q, 517D
CDD
cd11364 (RNase_PH_PNPase_2)

501D

active site
389Y, 391F, 408R, 412H, 446S, 447S, 448S, 495D, 501D, 503K, 515Q, 517D
CDD
cd11364 (RNase_PH_PNPase_2)

503K

active site
389Y, 391F, 408R, 412H, 446S, 447S, 448S, 495D, 501D, 503K, 515Q, 517D
CDD
cd11364 (RNase_PH_PNPase_2)

515Q

active site
389Y, 391F, 408R, 412H, 446S, 447S, 448S, 495D, 501D, 503K, 515Q, 517D
CDD
cd11364 (RNase_PH_PNPase_2)

517D

active site
389Y, 391F, 408R, 412H, 446S, 447S, 448S, 495D, 501D, 503K, 515Q, 517D
CDD
cd11364 (RNase_PH_PNPase_2)
putative nucleic a...

571D

putative nucleic acid binding region
571D, 573I, 574A, 575V, 577I, 578G, 579P, 580G, 581G, 584I, 585K, 588I, 589E, 594T, 595V, 596D, 597I
CDD
cd02393 (PNPase_KH)

573I

putative nucleic acid binding region
571D, 573I, 574A, 575V, 577I, 578G, 579P, 580G, 581G, 584I, 585K, 588I, 589E, 594T, 595V, 596D, 597I
CDD
cd02393 (PNPase_KH)

574A

putative nucleic acid binding region
571D, 573I, 574A, 575V, 577I, 578G, 579P, 580G, 581G, 584I, 585K, 588I, 589E, 594T, 595V, 596D, 597I
CDD
cd02393 (PNPase_KH)

575V

putative nucleic acid binding region
571D, 573I, 574A, 575V, 577I, 578G, 579P, 580G, 581G, 584I, 585K, 588I, 589E, 594T, 595V, 596D, 597I
CDD
cd02393 (PNPase_KH)

577I

putative nucleic acid binding region
571D, 573I, 574A, 575V, 577I, 578G, 579P, 580G, 581G, 584I, 585K, 588I, 589E, 594T, 595V, 596D, 597I
CDD
cd02393 (PNPase_KH)

578G

putative nucleic acid binding region
571D, 573I, 574A, 575V, 577I, 578G, 579P, 580G, 581G, 584I, 585K, 588I, 589E, 594T, 595V, 596D, 597I
CDD
cd02393 (PNPase_KH)

579P

putative nucleic acid binding region
571D, 573I, 574A, 575V, 577I, 578G, 579P, 580G, 581G, 584I, 585K, 588I, 589E, 594T, 595V, 596D, 597I
CDD
cd02393 (PNPase_KH)

580G

putative nucleic acid binding region
571D, 573I, 574A, 575V, 577I, 578G, 579P, 580G, 581G, 584I, 585K, 588I, 589E, 594T, 595V, 596D, 597I
CDD
cd02393 (PNPase_KH)

581G

putative nucleic acid binding region
571D, 573I, 574A, 575V, 577I, 578G, 579P, 580G, 581G, 584I, 585K, 588I, 589E, 594T, 595V, 596D, 597I
CDD
cd02393 (PNPase_KH)

584I

putative nucleic acid binding region
571D, 573I, 574A, 575V, 577I, 578G, 579P, 580G, 581G, 584I, 585K, 588I, 589E, 594T, 595V, 596D, 597I
CDD
cd02393 (PNPase_KH)

585K

putative nucleic acid binding region
571D, 573I, 574A, 575V, 577I, 578G, 579P, 580G, 581G, 584I, 585K, 588I, 589E, 594T, 595V, 596D, 597I
CDD
cd02393 (PNPase_KH)

588I

putative nucleic acid binding region
571D, 573I, 574A, 575V, 577I, 578G, 579P, 580G, 581G, 584I, 585K, 588I, 589E, 594T, 595V, 596D, 597I
CDD
cd02393 (PNPase_KH)

589E

putative nucleic acid binding region
571D, 573I, 574A, 575V, 577I, 578G, 579P, 580G, 581G, 584I, 585K, 588I, 589E, 594T, 595V, 596D, 597I
CDD
cd02393 (PNPase_KH)

594T

putative nucleic acid binding region
571D, 573I, 574A, 575V, 577I, 578G, 579P, 580G, 581G, 584I, 585K, 588I, 589E, 594T, 595V, 596D, 597I
CDD
cd02393 (PNPase_KH)

595V

putative nucleic acid binding region
571D, 573I, 574A, 575V, 577I, 578G, 579P, 580G, 581G, 584I, 585K, 588I, 589E, 594T, 595V, 596D, 597I
CDD
cd02393 (PNPase_KH)

596D

putative nucleic acid binding region
571D, 573I, 574A, 575V, 577I, 578G, 579P, 580G, 581G, 584I, 585K, 588I, 589E, 594T, 595V, 596D, 597I
CDD
cd02393 (PNPase_KH)

597I

putative nucleic acid binding region
571D, 573I, 574A, 575V, 577I, 578G, 579P, 580G, 581G, 584I, 585K, 588I, 589E, 594T, 595V, 596D, 597I
CDD
cd02393 (PNPase_KH)
G-X-X-G motif cd02...

578G

G-X-X-G motif
578G, 579P, 580G, 581G
CDD
cd02393 (PNPase_KH)

579P

G-X-X-G motif
578G, 579P, 580G, 581G
CDD
cd02393 (PNPase_KH)

580G

G-X-X-G motif
578G, 579P, 580G, 581G
CDD
cd02393 (PNPase_KH)

581G

G-X-X-G motif
578G, 579P, 580G, 581G
CDD
cd02393 (PNPase_KH)
RNA binding site c...

638V

RNA binding site
638V, 646F, 656L, 658H
CDD
cd04472 (S1_PNPase)

646F

RNA binding site
638V, 646F, 656L, 658H
CDD
cd04472 (S1_PNPase)

656L

RNA binding site
638V, 646F, 656L, 658H
CDD
cd04472 (S1_PNPase)

658H

RNA binding site
638V, 646F, 656L, 658H
CDD
cd04472 (S1_PNPase)
domain interface c...

677G

domain interface
677G, 678D
CDD
cd04472 (S1_PNPase)

678D

domain interface
677G, 678D
CDD
cd04472 (S1_PNPase)

GO term prediction

Biological Process

GO:0006396 RNA processing
GO:0006402 mRNA catabolic process

Molecular Function

GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0004654 polyribonucleotide nucleotidyltransferase activity

Cellular Component

None predicted.