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Entry type
Status
Per-residue features
Colour by
23726_FusoPortal_Gene_2106
Length
283 amino acids
Protein family membership
- Tetrahydrofolate dehydrogenase/cyclohydrolase (IPR000672)
Homologous superfamilies
-
Homologous superfamily122 - 276
- NAD(P)-binding domain superfamily (IPR036291)
1
50
100
150
200
250
283
Domains and repeats
-
Domain2 - 118123 - 278
1
50
100
150
200
250
283
Detailed signature matches

Unintegrated signatures
-
8 - 138
-
139 - 261
-
PTHR10025:SF46 (BIF...)2 - 280PANTHER
PTHR10025:SF46 (BIFUNCTIONAL METHYLENETETRAHYDROFOLATE DEHYDROGENASE/CYCLOHYDROLASE, MITOCHONDRIAL) -
SSF53223 (Aminoacid...)2 - 119
-
cd01080 (NAD_bind_m...)115 - 277
Residue annotation
-
homodimer interfac...122Ahomodimer interface
122A, 123E, 126G, 157G, 159D, 165S, 174A, 175A, 178L, 181R, 182G, 183T, 184V, 185T, 186I, 188N, 190Y, 191T, 200N
CDD
cd01080 (NAD_bind_m-THF_DH_Cyclohyd)123Ehomodimer interface
122A, 123E, 126G, 157G, 159D, 165S, 174A, 175A, 178L, 181R, 182G, 183T, 184V, 185T, 186I, 188N, 190Y, 191T, 200N
CDD
cd01080 (NAD_bind_m-THF_DH_Cyclohyd)126Ghomodimer interface
122A, 123E, 126G, 157G, 159D, 165S, 174A, 175A, 178L, 181R, 182G, 183T, 184V, 185T, 186I, 188N, 190Y, 191T, 200N
CDD
cd01080 (NAD_bind_m-THF_DH_Cyclohyd)157Ghomodimer interface
122A, 123E, 126G, 157G, 159D, 165S, 174A, 175A, 178L, 181R, 182G, 183T, 184V, 185T, 186I, 188N, 190Y, 191T, 200N
CDD
cd01080 (NAD_bind_m-THF_DH_Cyclohyd)159Dhomodimer interface
122A, 123E, 126G, 157G, 159D, 165S, 174A, 175A, 178L, 181R, 182G, 183T, 184V, 185T, 186I, 188N, 190Y, 191T, 200N
CDD
cd01080 (NAD_bind_m-THF_DH_Cyclohyd)165Shomodimer interface
122A, 123E, 126G, 157G, 159D, 165S, 174A, 175A, 178L, 181R, 182G, 183T, 184V, 185T, 186I, 188N, 190Y, 191T, 200N
CDD
cd01080 (NAD_bind_m-THF_DH_Cyclohyd)174Ahomodimer interface
122A, 123E, 126G, 157G, 159D, 165S, 174A, 175A, 178L, 181R, 182G, 183T, 184V, 185T, 186I, 188N, 190Y, 191T, 200N
CDD
cd01080 (NAD_bind_m-THF_DH_Cyclohyd)175Ahomodimer interface
122A, 123E, 126G, 157G, 159D, 165S, 174A, 175A, 178L, 181R, 182G, 183T, 184V, 185T, 186I, 188N, 190Y, 191T, 200N
CDD
cd01080 (NAD_bind_m-THF_DH_Cyclohyd)178Lhomodimer interface
122A, 123E, 126G, 157G, 159D, 165S, 174A, 175A, 178L, 181R, 182G, 183T, 184V, 185T, 186I, 188N, 190Y, 191T, 200N
CDD
cd01080 (NAD_bind_m-THF_DH_Cyclohyd)181Rhomodimer interface
122A, 123E, 126G, 157G, 159D, 165S, 174A, 175A, 178L, 181R, 182G, 183T, 184V, 185T, 186I, 188N, 190Y, 191T, 200N
CDD
cd01080 (NAD_bind_m-THF_DH_Cyclohyd)182Ghomodimer interface
122A, 123E, 126G, 157G, 159D, 165S, 174A, 175A, 178L, 181R, 182G, 183T, 184V, 185T, 186I, 188N, 190Y, 191T, 200N
CDD
cd01080 (NAD_bind_m-THF_DH_Cyclohyd)183Thomodimer interface
122A, 123E, 126G, 157G, 159D, 165S, 174A, 175A, 178L, 181R, 182G, 183T, 184V, 185T, 186I, 188N, 190Y, 191T, 200N
CDD
cd01080 (NAD_bind_m-THF_DH_Cyclohyd)184Vhomodimer interface
122A, 123E, 126G, 157G, 159D, 165S, 174A, 175A, 178L, 181R, 182G, 183T, 184V, 185T, 186I, 188N, 190Y, 191T, 200N
CDD
cd01080 (NAD_bind_m-THF_DH_Cyclohyd)185Thomodimer interface
122A, 123E, 126G, 157G, 159D, 165S, 174A, 175A, 178L, 181R, 182G, 183T, 184V, 185T, 186I, 188N, 190Y, 191T, 200N
CDD
cd01080 (NAD_bind_m-THF_DH_Cyclohyd)186Ihomodimer interface
122A, 123E, 126G, 157G, 159D, 165S, 174A, 175A, 178L, 181R, 182G, 183T, 184V, 185T, 186I, 188N, 190Y, 191T, 200N
CDD
cd01080 (NAD_bind_m-THF_DH_Cyclohyd)188Nhomodimer interface
122A, 123E, 126G, 157G, 159D, 165S, 174A, 175A, 178L, 181R, 182G, 183T, 184V, 185T, 186I, 188N, 190Y, 191T, 200N
CDD
cd01080 (NAD_bind_m-THF_DH_Cyclohyd)190Yhomodimer interface
122A, 123E, 126G, 157G, 159D, 165S, 174A, 175A, 178L, 181R, 182G, 183T, 184V, 185T, 186I, 188N, 190Y, 191T, 200N
CDD
cd01080 (NAD_bind_m-THF_DH_Cyclohyd)191Thomodimer interface
122A, 123E, 126G, 157G, 159D, 165S, 174A, 175A, 178L, 181R, 182G, 183T, 184V, 185T, 186I, 188N, 190Y, 191T, 200N
CDD
cd01080 (NAD_bind_m-THF_DH_Cyclohyd)200Nhomodimer interface
122A, 123E, 126G, 157G, 159D, 165S, 174A, 175A, 178L, 181R, 182G, 183T, 184V, 185T, 186I, 188N, 190Y, 191T, 200N
CDD
cd01080 (NAD_bind_m-THF_DH_Cyclohyd) -
NADP binding site ...140TNADP binding site
140T, 165S, 166S, 188N, 189I, 208V, 210K, 213L, 228V, 230I, 261G, 264T
CDD
cd01080 (NAD_bind_m-THF_DH_Cyclohyd)165SNADP binding site
140T, 165S, 166S, 188N, 189I, 208V, 210K, 213L, 228V, 230I, 261G, 264T
CDD
cd01080 (NAD_bind_m-THF_DH_Cyclohyd)166SNADP binding site
140T, 165S, 166S, 188N, 189I, 208V, 210K, 213L, 228V, 230I, 261G, 264T
CDD
cd01080 (NAD_bind_m-THF_DH_Cyclohyd)188NNADP binding site
140T, 165S, 166S, 188N, 189I, 208V, 210K, 213L, 228V, 230I, 261G, 264T
CDD
cd01080 (NAD_bind_m-THF_DH_Cyclohyd)189INADP binding site
140T, 165S, 166S, 188N, 189I, 208V, 210K, 213L, 228V, 230I, 261G, 264T
CDD
cd01080 (NAD_bind_m-THF_DH_Cyclohyd)208VNADP binding site
140T, 165S, 166S, 188N, 189I, 208V, 210K, 213L, 228V, 230I, 261G, 264T
CDD
cd01080 (NAD_bind_m-THF_DH_Cyclohyd)210KNADP binding site
140T, 165S, 166S, 188N, 189I, 208V, 210K, 213L, 228V, 230I, 261G, 264T
CDD
cd01080 (NAD_bind_m-THF_DH_Cyclohyd)213LNADP binding site
140T, 165S, 166S, 188N, 189I, 208V, 210K, 213L, 228V, 230I, 261G, 264T
CDD
cd01080 (NAD_bind_m-THF_DH_Cyclohyd)228VNADP binding site
140T, 165S, 166S, 188N, 189I, 208V, 210K, 213L, 228V, 230I, 261G, 264T
CDD
cd01080 (NAD_bind_m-THF_DH_Cyclohyd)230INADP binding site
140T, 165S, 166S, 188N, 189I, 208V, 210K, 213L, 228V, 230I, 261G, 264T
CDD
cd01080 (NAD_bind_m-THF_DH_Cyclohyd)261GNADP binding site
140T, 165S, 166S, 188N, 189I, 208V, 210K, 213L, 228V, 230I, 261G, 264T
CDD
cd01080 (NAD_bind_m-THF_DH_Cyclohyd)264TNADP binding site
140T, 165S, 166S, 188N, 189I, 208V, 210K, 213L, 228V, 230I, 261G, 264T
CDD
cd01080 (NAD_bind_m-THF_DH_Cyclohyd) -
substrate binding ...
GO term prediction
Biological Process
GO:0055114 oxidation-reduction process
Molecular Function
GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity
Cellular Component
None predicted.