23726_FusoPortal_Gene_251

Protein

23726_FusoPortal_Gene_251

Length

400 amino acids

Protein family membership

Cys/Met metabolism, pyridoxal phosphate-dependent enzyme (IPR000277)

Homologous superfamilies

Homologous superfamily
6 - 259
Pyridoxal phosphate-dependent transferase, major region, subdomain 1 (IPR015421)
262 - 400
Pyridoxal phosphate-dependent transferase, subdomain 2 (IPR015422)
Homologous superfamily
54 - 394
Pyridoxal phosphate-dependent transferase (IPR015424)

1 50 100 150 200 250 300 350 400 400

Domains and repeats

None predicted.

Detailed signature matches

IPR015421

Pyridoxal phosphate-dependent transferase, major region, subdomain 1
1. G3DSA:3.40.64...
  
  6 - 259
  
  GENE3D
  G3DSA:3.40.640.10 (G3DSA:3.40.640.10)
IPR015424

Pyridoxal phosphate-dependent transferase
1. SSF53383 (PLP-depen...)
  
  54 - 394
  
  SUPERFAMILY
  SSF53383 (PLP-dependent transferases)
IPR015422

Pyridoxal phosphate-dependent transferase, subdomain 2
1. G3DSA:3.90.11...
  
  262 - 400
  
  GENE3D
  G3DSA:3.90.1150.10 (G3DSA:3.90.1150.10)
IPR000277

Cys/Met metabolism, pyridoxal phosphate-dependent enzyme
1. cd00614 (CGS_like)
  
  28 - 394
  
  CDD
  cd00614 (CGS_like)
2. PTHR11808 (TRANS-SU...)
  
  12 - 395
  
  PANTHER
  PTHR11808 (TRANS-SULFURATION ENZYME FAMILY MEMBER)
3. PIRSF001434 (CGS)
  
  2 - 397
  
  PIRSF
  PIRSF001434 (CGS)
4. PF01053 (Cys_Met_Me...)
  
  26 - 394
  
  Pfam
  PF01053 (Cys_Met_Meta_PP)

no IPR

Unintegrated signatures

PTHR11808:SF72 (CYS...)

12 - 395

PANTHER
PTHR11808:SF72 (CYSTATHIONINE BETA LYASE)

Residue annotation

homodimer interfac...

36L

homodimer interface
36L, 37T, 38T, 39A, 41N, 42V, 59Y, 61R, 87S, 88S, 90M, 91A, 114Y, 119E, 122T, 210T, 218D, 220V, 236E, 246D, 248F, 249S, 329R
CDD
cd00614 (CGS_like)

37T

homodimer interface
36L, 37T, 38T, 39A, 41N, 42V, 59Y, 61R, 87S, 88S, 90M, 91A, 114Y, 119E, 122T, 210T, 218D, 220V, 236E, 246D, 248F, 249S, 329R
CDD
cd00614 (CGS_like)

38T

homodimer interface
36L, 37T, 38T, 39A, 41N, 42V, 59Y, 61R, 87S, 88S, 90M, 91A, 114Y, 119E, 122T, 210T, 218D, 220V, 236E, 246D, 248F, 249S, 329R
CDD
cd00614 (CGS_like)

39A

homodimer interface
36L, 37T, 38T, 39A, 41N, 42V, 59Y, 61R, 87S, 88S, 90M, 91A, 114Y, 119E, 122T, 210T, 218D, 220V, 236E, 246D, 248F, 249S, 329R
CDD
cd00614 (CGS_like)

41N

homodimer interface
36L, 37T, 38T, 39A, 41N, 42V, 59Y, 61R, 87S, 88S, 90M, 91A, 114Y, 119E, 122T, 210T, 218D, 220V, 236E, 246D, 248F, 249S, 329R
CDD
cd00614 (CGS_like)

42V

homodimer interface
36L, 37T, 38T, 39A, 41N, 42V, 59Y, 61R, 87S, 88S, 90M, 91A, 114Y, 119E, 122T, 210T, 218D, 220V, 236E, 246D, 248F, 249S, 329R
CDD
cd00614 (CGS_like)

59Y

homodimer interface
36L, 37T, 38T, 39A, 41N, 42V, 59Y, 61R, 87S, 88S, 90M, 91A, 114Y, 119E, 122T, 210T, 218D, 220V, 236E, 246D, 248F, 249S, 329R
CDD
cd00614 (CGS_like)

61R

homodimer interface
36L, 37T, 38T, 39A, 41N, 42V, 59Y, 61R, 87S, 88S, 90M, 91A, 114Y, 119E, 122T, 210T, 218D, 220V, 236E, 246D, 248F, 249S, 329R
CDD
cd00614 (CGS_like)

87S

homodimer interface
36L, 37T, 38T, 39A, 41N, 42V, 59Y, 61R, 87S, 88S, 90M, 91A, 114Y, 119E, 122T, 210T, 218D, 220V, 236E, 246D, 248F, 249S, 329R
CDD
cd00614 (CGS_like)

88S

homodimer interface
36L, 37T, 38T, 39A, 41N, 42V, 59Y, 61R, 87S, 88S, 90M, 91A, 114Y, 119E, 122T, 210T, 218D, 220V, 236E, 246D, 248F, 249S, 329R
CDD
cd00614 (CGS_like)

90M

homodimer interface
36L, 37T, 38T, 39A, 41N, 42V, 59Y, 61R, 87S, 88S, 90M, 91A, 114Y, 119E, 122T, 210T, 218D, 220V, 236E, 246D, 248F, 249S, 329R
CDD
cd00614 (CGS_like)

91A

homodimer interface
36L, 37T, 38T, 39A, 41N, 42V, 59Y, 61R, 87S, 88S, 90M, 91A, 114Y, 119E, 122T, 210T, 218D, 220V, 236E, 246D, 248F, 249S, 329R
CDD
cd00614 (CGS_like)

114Y

homodimer interface
36L, 37T, 38T, 39A, 41N, 42V, 59Y, 61R, 87S, 88S, 90M, 91A, 114Y, 119E, 122T, 210T, 218D, 220V, 236E, 246D, 248F, 249S, 329R
CDD
cd00614 (CGS_like)

119E

homodimer interface
36L, 37T, 38T, 39A, 41N, 42V, 59Y, 61R, 87S, 88S, 90M, 91A, 114Y, 119E, 122T, 210T, 218D, 220V, 236E, 246D, 248F, 249S, 329R
CDD
cd00614 (CGS_like)

122T

homodimer interface
36L, 37T, 38T, 39A, 41N, 42V, 59Y, 61R, 87S, 88S, 90M, 91A, 114Y, 119E, 122T, 210T, 218D, 220V, 236E, 246D, 248F, 249S, 329R
CDD
cd00614 (CGS_like)

210T

homodimer interface
36L, 37T, 38T, 39A, 41N, 42V, 59Y, 61R, 87S, 88S, 90M, 91A, 114Y, 119E, 122T, 210T, 218D, 220V, 236E, 246D, 248F, 249S, 329R
CDD
cd00614 (CGS_like)

218D

homodimer interface
36L, 37T, 38T, 39A, 41N, 42V, 59Y, 61R, 87S, 88S, 90M, 91A, 114Y, 119E, 122T, 210T, 218D, 220V, 236E, 246D, 248F, 249S, 329R
CDD
cd00614 (CGS_like)

220V

homodimer interface
36L, 37T, 38T, 39A, 41N, 42V, 59Y, 61R, 87S, 88S, 90M, 91A, 114Y, 119E, 122T, 210T, 218D, 220V, 236E, 246D, 248F, 249S, 329R
CDD
cd00614 (CGS_like)

236E

homodimer interface
36L, 37T, 38T, 39A, 41N, 42V, 59Y, 61R, 87S, 88S, 90M, 91A, 114Y, 119E, 122T, 210T, 218D, 220V, 236E, 246D, 248F, 249S, 329R
CDD
cd00614 (CGS_like)

246D

homodimer interface
36L, 37T, 38T, 39A, 41N, 42V, 59Y, 61R, 87S, 88S, 90M, 91A, 114Y, 119E, 122T, 210T, 218D, 220V, 236E, 246D, 248F, 249S, 329R
CDD
cd00614 (CGS_like)

248F

homodimer interface
36L, 37T, 38T, 39A, 41N, 42V, 59Y, 61R, 87S, 88S, 90M, 91A, 114Y, 119E, 122T, 210T, 218D, 220V, 236E, 246D, 248F, 249S, 329R
CDD
cd00614 (CGS_like)

249S

homodimer interface
36L, 37T, 38T, 39A, 41N, 42V, 59Y, 61R, 87S, 88S, 90M, 91A, 114Y, 119E, 122T, 210T, 218D, 220V, 236E, 246D, 248F, 249S, 329R
CDD
cd00614 (CGS_like)

329R

homodimer interface
36L, 37T, 38T, 39A, 41N, 42V, 59Y, 61R, 87S, 88S, 90M, 91A, 114Y, 119E, 122T, 210T, 218D, 220V, 236E, 246D, 248F, 249S, 329R
CDD
cd00614 (CGS_like)
pyridoxal 5'-phosp...

88S

pyridoxal 5'-phosphate binding site
88S, 89G, 90M, 114Y, 186D, 189F, 208S, 210T, 211K
CDD
cd00614 (CGS_like)

89G

pyridoxal 5'-phosphate binding site
88S, 89G, 90M, 114Y, 186D, 189F, 208S, 210T, 211K
CDD
cd00614 (CGS_like)

90M

pyridoxal 5'-phosphate binding site
88S, 89G, 90M, 114Y, 186D, 189F, 208S, 210T, 211K
CDD
cd00614 (CGS_like)

114Y

pyridoxal 5'-phosphate binding site
88S, 89G, 90M, 114Y, 186D, 189F, 208S, 210T, 211K
CDD
cd00614 (CGS_like)

186D

pyridoxal 5'-phosphate binding site
88S, 89G, 90M, 114Y, 186D, 189F, 208S, 210T, 211K
CDD
cd00614 (CGS_like)

189F

pyridoxal 5'-phosphate binding site
88S, 89G, 90M, 114Y, 186D, 189F, 208S, 210T, 211K
CDD
cd00614 (CGS_like)

208S

pyridoxal 5'-phosphate binding site
88S, 89G, 90M, 114Y, 186D, 189F, 208S, 210T, 211K
CDD
cd00614 (CGS_like)

210T

pyridoxal 5'-phosphate binding site
88S, 89G, 90M, 114Y, 186D, 189F, 208S, 210T, 211K
CDD
cd00614 (CGS_like)

211K

pyridoxal 5'-phosphate binding site
88S, 89G, 90M, 114Y, 186D, 189F, 208S, 210T, 211K
CDD
cd00614 (CGS_like)
substrate-cofactor...

88S

substrate-cofactor binding pocket
88S, 89G, 90M, 114Y, 157E, 186D, 208S, 210T, 211K, 220V
CDD
cd00614 (CGS_like)

89G

substrate-cofactor binding pocket
88S, 89G, 90M, 114Y, 157E, 186D, 208S, 210T, 211K, 220V
CDD
cd00614 (CGS_like)

90M

substrate-cofactor binding pocket
88S, 89G, 90M, 114Y, 157E, 186D, 208S, 210T, 211K, 220V
CDD
cd00614 (CGS_like)

114Y

substrate-cofactor binding pocket
88S, 89G, 90M, 114Y, 157E, 186D, 208S, 210T, 211K, 220V
CDD
cd00614 (CGS_like)

157E

substrate-cofactor binding pocket
88S, 89G, 90M, 114Y, 157E, 186D, 208S, 210T, 211K, 220V
CDD
cd00614 (CGS_like)

186D

substrate-cofactor binding pocket
88S, 89G, 90M, 114Y, 157E, 186D, 208S, 210T, 211K, 220V
CDD
cd00614 (CGS_like)

208S

substrate-cofactor binding pocket
88S, 89G, 90M, 114Y, 157E, 186D, 208S, 210T, 211K, 220V
CDD
cd00614 (CGS_like)

210T

substrate-cofactor binding pocket
88S, 89G, 90M, 114Y, 157E, 186D, 208S, 210T, 211K, 220V
CDD
cd00614 (CGS_like)

211K

substrate-cofactor binding pocket
88S, 89G, 90M, 114Y, 157E, 186D, 208S, 210T, 211K, 220V
CDD
cd00614 (CGS_like)

220V

substrate-cofactor binding pocket
88S, 89G, 90M, 114Y, 157E, 186D, 208S, 210T, 211K, 220V
CDD
cd00614 (CGS_like)
catalytic residue ...

211K

catalytic residue
211K
CDD
cd00614 (CGS_like)

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0003824 catalytic activity
GO:0030170 pyridoxal phosphate binding

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features

23726_FusoPortal_Gene_251

Protein family membership

Homologous superfamilies

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component