23726_FusoPortal_Gene_277

Protein

23726_FusoPortal_Gene_277

Length

173 amino acids

Protein family membership

ATP:cob(I)alamin adenosyltransferase CobA/CobO/ButR (IPR003724)

Homologous superfamilies

Homologous superfamily
2 - 172
P-loop containing nucleoside triphosphate hydrolase (IPR027417)

1 20 40 60 80 100 120 140 160 173

Domains and repeats

None predicted.

Detailed signature matches

IPR027417

P-loop containing nucleoside triphosphate hydrolase
1. SSF52540 (P-loop co...)
  
  2 - 172
  
  SUPERFAMILY
  SSF52540 (P-loop containing nucleoside triphosphate hydrolases)
IPR003724

ATP:cob(I)alamin adenosyltransferase CobA/CobO/ButR
1. PF02572 (CobA_CobO_...)
  
  2 - 172
  
  Pfam
  PF02572 (CobA_CobO_BtuR)
2. cd00561 (CobA_CobO_...)
  
  2 - 161
  
  CDD
  cd00561 (CobA_CobO_BtuR)
3. PIRSF015617 (Adenos...)
  
  1 - 173
  
  PIRSF
  PIRSF015617 (Adenosyltransferase_CobA)

no IPR

Unintegrated signatures

Coil

173 - 173

COILS
Coil (Coil)
G3DSA:3.40.50...

1 - 172

GENE3D
G3DSA:3.40.50.300 (G3DSA:3.40.50.300)

Residue annotation

homodimer interfac...

3K

homodimer interface
3K, 14K, 18T, 22G, 23L, 25T, 26R, 27A, 28V, 29G, 30S, 44D, 46G, 47E, 49Y, 50T, 132E, 145I, 146E, 148A, 149D, 150L, 151V, 152T, 153E, 154M, 155R, 157V, 158K, 160Y
CDD
cd00561 (CobA_CobO_BtuR)

14K

homodimer interface
3K, 14K, 18T, 22G, 23L, 25T, 26R, 27A, 28V, 29G, 30S, 44D, 46G, 47E, 49Y, 50T, 132E, 145I, 146E, 148A, 149D, 150L, 151V, 152T, 153E, 154M, 155R, 157V, 158K, 160Y
CDD
cd00561 (CobA_CobO_BtuR)

18T

homodimer interface
3K, 14K, 18T, 22G, 23L, 25T, 26R, 27A, 28V, 29G, 30S, 44D, 46G, 47E, 49Y, 50T, 132E, 145I, 146E, 148A, 149D, 150L, 151V, 152T, 153E, 154M, 155R, 157V, 158K, 160Y
CDD
cd00561 (CobA_CobO_BtuR)

22G

homodimer interface
3K, 14K, 18T, 22G, 23L, 25T, 26R, 27A, 28V, 29G, 30S, 44D, 46G, 47E, 49Y, 50T, 132E, 145I, 146E, 148A, 149D, 150L, 151V, 152T, 153E, 154M, 155R, 157V, 158K, 160Y
CDD
cd00561 (CobA_CobO_BtuR)

23L

homodimer interface
3K, 14K, 18T, 22G, 23L, 25T, 26R, 27A, 28V, 29G, 30S, 44D, 46G, 47E, 49Y, 50T, 132E, 145I, 146E, 148A, 149D, 150L, 151V, 152T, 153E, 154M, 155R, 157V, 158K, 160Y
CDD
cd00561 (CobA_CobO_BtuR)

25T

homodimer interface
3K, 14K, 18T, 22G, 23L, 25T, 26R, 27A, 28V, 29G, 30S, 44D, 46G, 47E, 49Y, 50T, 132E, 145I, 146E, 148A, 149D, 150L, 151V, 152T, 153E, 154M, 155R, 157V, 158K, 160Y
CDD
cd00561 (CobA_CobO_BtuR)

26R

homodimer interface
3K, 14K, 18T, 22G, 23L, 25T, 26R, 27A, 28V, 29G, 30S, 44D, 46G, 47E, 49Y, 50T, 132E, 145I, 146E, 148A, 149D, 150L, 151V, 152T, 153E, 154M, 155R, 157V, 158K, 160Y
CDD
cd00561 (CobA_CobO_BtuR)

27A

homodimer interface
3K, 14K, 18T, 22G, 23L, 25T, 26R, 27A, 28V, 29G, 30S, 44D, 46G, 47E, 49Y, 50T, 132E, 145I, 146E, 148A, 149D, 150L, 151V, 152T, 153E, 154M, 155R, 157V, 158K, 160Y
CDD
cd00561 (CobA_CobO_BtuR)

28V

homodimer interface
3K, 14K, 18T, 22G, 23L, 25T, 26R, 27A, 28V, 29G, 30S, 44D, 46G, 47E, 49Y, 50T, 132E, 145I, 146E, 148A, 149D, 150L, 151V, 152T, 153E, 154M, 155R, 157V, 158K, 160Y
CDD
cd00561 (CobA_CobO_BtuR)

29G

homodimer interface
3K, 14K, 18T, 22G, 23L, 25T, 26R, 27A, 28V, 29G, 30S, 44D, 46G, 47E, 49Y, 50T, 132E, 145I, 146E, 148A, 149D, 150L, 151V, 152T, 153E, 154M, 155R, 157V, 158K, 160Y
CDD
cd00561 (CobA_CobO_BtuR)

30S

homodimer interface
3K, 14K, 18T, 22G, 23L, 25T, 26R, 27A, 28V, 29G, 30S, 44D, 46G, 47E, 49Y, 50T, 132E, 145I, 146E, 148A, 149D, 150L, 151V, 152T, 153E, 154M, 155R, 157V, 158K, 160Y
CDD
cd00561 (CobA_CobO_BtuR)

44D

homodimer interface
3K, 14K, 18T, 22G, 23L, 25T, 26R, 27A, 28V, 29G, 30S, 44D, 46G, 47E, 49Y, 50T, 132E, 145I, 146E, 148A, 149D, 150L, 151V, 152T, 153E, 154M, 155R, 157V, 158K, 160Y
CDD
cd00561 (CobA_CobO_BtuR)

46G

homodimer interface
3K, 14K, 18T, 22G, 23L, 25T, 26R, 27A, 28V, 29G, 30S, 44D, 46G, 47E, 49Y, 50T, 132E, 145I, 146E, 148A, 149D, 150L, 151V, 152T, 153E, 154M, 155R, 157V, 158K, 160Y
CDD
cd00561 (CobA_CobO_BtuR)

47E

homodimer interface
3K, 14K, 18T, 22G, 23L, 25T, 26R, 27A, 28V, 29G, 30S, 44D, 46G, 47E, 49Y, 50T, 132E, 145I, 146E, 148A, 149D, 150L, 151V, 152T, 153E, 154M, 155R, 157V, 158K, 160Y
CDD
cd00561 (CobA_CobO_BtuR)

49Y

homodimer interface
3K, 14K, 18T, 22G, 23L, 25T, 26R, 27A, 28V, 29G, 30S, 44D, 46G, 47E, 49Y, 50T, 132E, 145I, 146E, 148A, 149D, 150L, 151V, 152T, 153E, 154M, 155R, 157V, 158K, 160Y
CDD
cd00561 (CobA_CobO_BtuR)

50T

homodimer interface
3K, 14K, 18T, 22G, 23L, 25T, 26R, 27A, 28V, 29G, 30S, 44D, 46G, 47E, 49Y, 50T, 132E, 145I, 146E, 148A, 149D, 150L, 151V, 152T, 153E, 154M, 155R, 157V, 158K, 160Y
CDD
cd00561 (CobA_CobO_BtuR)

132E

homodimer interface
3K, 14K, 18T, 22G, 23L, 25T, 26R, 27A, 28V, 29G, 30S, 44D, 46G, 47E, 49Y, 50T, 132E, 145I, 146E, 148A, 149D, 150L, 151V, 152T, 153E, 154M, 155R, 157V, 158K, 160Y
CDD
cd00561 (CobA_CobO_BtuR)

145I

homodimer interface
3K, 14K, 18T, 22G, 23L, 25T, 26R, 27A, 28V, 29G, 30S, 44D, 46G, 47E, 49Y, 50T, 132E, 145I, 146E, 148A, 149D, 150L, 151V, 152T, 153E, 154M, 155R, 157V, 158K, 160Y
CDD
cd00561 (CobA_CobO_BtuR)

146E

homodimer interface
3K, 14K, 18T, 22G, 23L, 25T, 26R, 27A, 28V, 29G, 30S, 44D, 46G, 47E, 49Y, 50T, 132E, 145I, 146E, 148A, 149D, 150L, 151V, 152T, 153E, 154M, 155R, 157V, 158K, 160Y
CDD
cd00561 (CobA_CobO_BtuR)

148A

homodimer interface
3K, 14K, 18T, 22G, 23L, 25T, 26R, 27A, 28V, 29G, 30S, 44D, 46G, 47E, 49Y, 50T, 132E, 145I, 146E, 148A, 149D, 150L, 151V, 152T, 153E, 154M, 155R, 157V, 158K, 160Y
CDD
cd00561 (CobA_CobO_BtuR)

149D

homodimer interface
3K, 14K, 18T, 22G, 23L, 25T, 26R, 27A, 28V, 29G, 30S, 44D, 46G, 47E, 49Y, 50T, 132E, 145I, 146E, 148A, 149D, 150L, 151V, 152T, 153E, 154M, 155R, 157V, 158K, 160Y
CDD
cd00561 (CobA_CobO_BtuR)

150L

homodimer interface
3K, 14K, 18T, 22G, 23L, 25T, 26R, 27A, 28V, 29G, 30S, 44D, 46G, 47E, 49Y, 50T, 132E, 145I, 146E, 148A, 149D, 150L, 151V, 152T, 153E, 154M, 155R, 157V, 158K, 160Y
CDD
cd00561 (CobA_CobO_BtuR)

151V

homodimer interface
3K, 14K, 18T, 22G, 23L, 25T, 26R, 27A, 28V, 29G, 30S, 44D, 46G, 47E, 49Y, 50T, 132E, 145I, 146E, 148A, 149D, 150L, 151V, 152T, 153E, 154M, 155R, 157V, 158K, 160Y
CDD
cd00561 (CobA_CobO_BtuR)

152T

homodimer interface
3K, 14K, 18T, 22G, 23L, 25T, 26R, 27A, 28V, 29G, 30S, 44D, 46G, 47E, 49Y, 50T, 132E, 145I, 146E, 148A, 149D, 150L, 151V, 152T, 153E, 154M, 155R, 157V, 158K, 160Y
CDD
cd00561 (CobA_CobO_BtuR)

153E

homodimer interface
3K, 14K, 18T, 22G, 23L, 25T, 26R, 27A, 28V, 29G, 30S, 44D, 46G, 47E, 49Y, 50T, 132E, 145I, 146E, 148A, 149D, 150L, 151V, 152T, 153E, 154M, 155R, 157V, 158K, 160Y
CDD
cd00561 (CobA_CobO_BtuR)

154M

homodimer interface
3K, 14K, 18T, 22G, 23L, 25T, 26R, 27A, 28V, 29G, 30S, 44D, 46G, 47E, 49Y, 50T, 132E, 145I, 146E, 148A, 149D, 150L, 151V, 152T, 153E, 154M, 155R, 157V, 158K, 160Y
CDD
cd00561 (CobA_CobO_BtuR)

155R

homodimer interface
3K, 14K, 18T, 22G, 23L, 25T, 26R, 27A, 28V, 29G, 30S, 44D, 46G, 47E, 49Y, 50T, 132E, 145I, 146E, 148A, 149D, 150L, 151V, 152T, 153E, 154M, 155R, 157V, 158K, 160Y
CDD
cd00561 (CobA_CobO_BtuR)

157V

homodimer interface
3K, 14K, 18T, 22G, 23L, 25T, 26R, 27A, 28V, 29G, 30S, 44D, 46G, 47E, 49Y, 50T, 132E, 145I, 146E, 148A, 149D, 150L, 151V, 152T, 153E, 154M, 155R, 157V, 158K, 160Y
CDD
cd00561 (CobA_CobO_BtuR)

158K

homodimer interface
3K, 14K, 18T, 22G, 23L, 25T, 26R, 27A, 28V, 29G, 30S, 44D, 46G, 47E, 49Y, 50T, 132E, 145I, 146E, 148A, 149D, 150L, 151V, 152T, 153E, 154M, 155R, 157V, 158K, 160Y
CDD
cd00561 (CobA_CobO_BtuR)

160Y

homodimer interface
3K, 14K, 18T, 22G, 23L, 25T, 26R, 27A, 28V, 29G, 30S, 44D, 46G, 47E, 49Y, 50T, 132E, 145I, 146E, 148A, 149D, 150L, 151V, 152T, 153E, 154M, 155R, 157V, 158K, 160Y
CDD
cd00561 (CobA_CobO_BtuR)
Walker A motif cd0...

11G

Walker A motif
11G, 12N, 13G, 14K, 15G, 16K, 17T
CDD
cd00561 (CobA_CobO_BtuR)

12N

Walker A motif
11G, 12N, 13G, 14K, 15G, 16K, 17T
CDD
cd00561 (CobA_CobO_BtuR)

13G

Walker A motif
11G, 12N, 13G, 14K, 15G, 16K, 17T
CDD
cd00561 (CobA_CobO_BtuR)

14K

Walker A motif
11G, 12N, 13G, 14K, 15G, 16K, 17T
CDD
cd00561 (CobA_CobO_BtuR)

15G

Walker A motif
11G, 12N, 13G, 14K, 15G, 16K, 17T
CDD
cd00561 (CobA_CobO_BtuR)

16K

Walker A motif
11G, 12N, 13G, 14K, 15G, 16K, 17T
CDD
cd00561 (CobA_CobO_BtuR)

17T

Walker A motif
11G, 12N, 13G, 14K, 15G, 16K, 17T
CDD
cd00561 (CobA_CobO_BtuR)
ATP binding site c...

14K

ATP binding site
14K, 16K, 17T, 18T, 26R, 105E
CDD
cd00561 (CobA_CobO_BtuR)

16K

ATP binding site
14K, 16K, 17T, 18T, 26R, 105E
CDD
cd00561 (CobA_CobO_BtuR)

17T

ATP binding site
14K, 16K, 17T, 18T, 26R, 105E
CDD
cd00561 (CobA_CobO_BtuR)

18T

ATP binding site
14K, 16K, 17T, 18T, 26R, 105E
CDD
cd00561 (CobA_CobO_BtuR)

26R

ATP binding site
14K, 16K, 17T, 18T, 26R, 105E
CDD
cd00561 (CobA_CobO_BtuR)

105E

ATP binding site
14K, 16K, 17T, 18T, 26R, 105E
CDD
cd00561 (CobA_CobO_BtuR)
hydroxycobalamin b...

41K

hydroxycobalamin binding site
41K, 43R, 68I, 108G, 112Y, 138R, 161F
CDD
cd00561 (CobA_CobO_BtuR)

43R

hydroxycobalamin binding site
41K, 43R, 68I, 108G, 112Y, 138R, 161F
CDD
cd00561 (CobA_CobO_BtuR)

68I

hydroxycobalamin binding site
41K, 43R, 68I, 108G, 112Y, 138R, 161F
CDD
cd00561 (CobA_CobO_BtuR)

108G

hydroxycobalamin binding site
41K, 43R, 68I, 108G, 112Y, 138R, 161F
CDD
cd00561 (CobA_CobO_BtuR)

112Y

hydroxycobalamin binding site
41K, 43R, 68I, 108G, 112Y, 138R, 161F
CDD
cd00561 (CobA_CobO_BtuR)

138R

hydroxycobalamin binding site
41K, 43R, 68I, 108G, 112Y, 138R, 161F
CDD
cd00561 (CobA_CobO_BtuR)

161F

hydroxycobalamin binding site
41K, 43R, 68I, 108G, 112Y, 138R, 161F
CDD
cd00561 (CobA_CobO_BtuR)
Walker B motif cd0...

100I

Walker B motif
100I, 101V, 102I, 103A, 104D
CDD
cd00561 (CobA_CobO_BtuR)

101V

Walker B motif
100I, 101V, 102I, 103A, 104D
CDD
cd00561 (CobA_CobO_BtuR)

102I

Walker B motif
100I, 101V, 102I, 103A, 104D
CDD
cd00561 (CobA_CobO_BtuR)

103A

Walker B motif
100I, 101V, 102I, 103A, 104D
CDD
cd00561 (CobA_CobO_BtuR)

104D

Walker B motif
100I, 101V, 102I, 103A, 104D
CDD
cd00561 (CobA_CobO_BtuR)

GO term prediction

Biological Process

GO:0009236 cobalamin biosynthetic process

Molecular Function

GO:0005524 ATP binding
GO:0008817 cob(I)yrinic acid a,c-diamide adenosyltransferase activity

Cellular Component

None predicted.

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Entry type

Status

Per-residue features

23726_FusoPortal_Gene_277

Protein family membership

Homologous superfamilies

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component