23726_FusoPortal_Gene_278

Protein

23726_FusoPortal_Gene_278

Length

252 amino acids

Protein family membership

Mutator MutX protein (IPR003562)

Homologous superfamilies

Homologous superfamily
3 - 141
NUDIX hydrolase-like domain superfamily (IPR015797)
153 - 252
Nitrogen regulatory protein PII/ATP phosphoribosyltransferase, C-terminal (IPR015867)
Homologous superfamily
151 - 251
GTP cyclohydrolase 1 type 2/Nif3 superfamily (IPR036069)

1 50 100 150 200 252

Domains and repeats

Domain
1 - 127
NUDIX hydrolase domain (IPR000086)

1 50 100 150 200 252

Detailed signature matches

IPR015797

NUDIX hydrolase-like domain superfamily
1. SSF55811 (Nudix)
  
  3 - 141
  
  SUPERFAMILY
  SSF55811 (Nudix)
IPR036069

GTP cyclohydrolase 1 type 2/Nif3 superfamily
1. SSF102705 (NIF3 (NG...)
  
  151 - 251
  
  SUPERFAMILY
  SSF102705 (NIF3 (NGG1p interacting factor 3)-like)
IPR015867

Nitrogen regulatory protein PII/ATP phosphoribosyltransferase, C-terminal
1. G3DSA:3.30.70...
  
  153 - 252
  
  GENE3D
  G3DSA:3.30.70.120 (G3DSA:3.30.70.120)
IPR003562

Mutator MutX protein
1. PR01402 (MUTATORMUTX)
  
  115 - 132
  
  PRINTS
  PR01402 (MUTATORMUTX)
  
  20 - 35
  
  PRINTS
  PR01402 (MUTATORMUTX)
  
  95 - 115
  
  PRINTS
  PR01402 (MUTATORMUTX)
  
  65 - 91
  
  PRINTS
  PR01402 (MUTATORMUTX)
  
  132 - 152
  
  PRINTS
  PR01402 (MUTATORMUTX)
  
  2 - 20
  
  PRINTS
  PR01402 (MUTATORMUTX)
IPR000086

NUDIX hydrolase domain
1. PS51462 (NUDIX)
  
  1 - 127
  
  PROSITE profiles
  PS51462 (NUDIX)
2. PF00293 (NUDIX)
  
  8 - 123
  
  Pfam
  PF00293 (NUDIX)
IPR020084

NUDIX hydrolase, conserved site
1. PS00893 (NUDIX_BOX)
  
  36 - 57
  
  PROSITE patterns
  PS00893 (NUDIX_BOX)

no IPR

Unintegrated signatures

G3DSA:3.90.79.10

2 - 152

GENE3D
G3DSA:3.90.79.10 (G3DSA:3.90.79.10)
PTHR42904 (FAMILY N...)

2 - 210

PANTHER
PTHR42904 (FAMILY NOT NAMED)
PTHR42904:SF3 (SUBF...)

2 - 210

PANTHER
PTHR42904:SF3 (SUBFAMILY NOT NAMED)
cd03427 (MTH1)

1 - 134

CDD
cd03427 (MTH1)

Residue annotation

putative active si...

1M

putative active site
1M, 3T, 5L, 32L, 37K, 50R, 51E, 54E, 55E, 71F, 79L, 81M, 97S, 98E, 115W, 117G
CDD
cd03427 (MTH1)

3T

putative active site
1M, 3T, 5L, 32L, 37K, 50R, 51E, 54E, 55E, 71F, 79L, 81M, 97S, 98E, 115W, 117G
CDD
cd03427 (MTH1)

5L

putative active site
1M, 3T, 5L, 32L, 37K, 50R, 51E, 54E, 55E, 71F, 79L, 81M, 97S, 98E, 115W, 117G
CDD
cd03427 (MTH1)

32L

putative active site
1M, 3T, 5L, 32L, 37K, 50R, 51E, 54E, 55E, 71F, 79L, 81M, 97S, 98E, 115W, 117G
CDD
cd03427 (MTH1)

37K

putative active site
1M, 3T, 5L, 32L, 37K, 50R, 51E, 54E, 55E, 71F, 79L, 81M, 97S, 98E, 115W, 117G
CDD
cd03427 (MTH1)

50R

putative active site
1M, 3T, 5L, 32L, 37K, 50R, 51E, 54E, 55E, 71F, 79L, 81M, 97S, 98E, 115W, 117G
CDD
cd03427 (MTH1)

51E

putative active site
1M, 3T, 5L, 32L, 37K, 50R, 51E, 54E, 55E, 71F, 79L, 81M, 97S, 98E, 115W, 117G
CDD
cd03427 (MTH1)

54E

putative active site
1M, 3T, 5L, 32L, 37K, 50R, 51E, 54E, 55E, 71F, 79L, 81M, 97S, 98E, 115W, 117G
CDD
cd03427 (MTH1)

55E

putative active site
1M, 3T, 5L, 32L, 37K, 50R, 51E, 54E, 55E, 71F, 79L, 81M, 97S, 98E, 115W, 117G
CDD
cd03427 (MTH1)

71F

putative active site
1M, 3T, 5L, 32L, 37K, 50R, 51E, 54E, 55E, 71F, 79L, 81M, 97S, 98E, 115W, 117G
CDD
cd03427 (MTH1)

79L

putative active site
1M, 3T, 5L, 32L, 37K, 50R, 51E, 54E, 55E, 71F, 79L, 81M, 97S, 98E, 115W, 117G
CDD
cd03427 (MTH1)

81M

putative active site
1M, 3T, 5L, 32L, 37K, 50R, 51E, 54E, 55E, 71F, 79L, 81M, 97S, 98E, 115W, 117G
CDD
cd03427 (MTH1)

97S

putative active site
1M, 3T, 5L, 32L, 37K, 50R, 51E, 54E, 55E, 71F, 79L, 81M, 97S, 98E, 115W, 117G
CDD
cd03427 (MTH1)

98E

putative active site
1M, 3T, 5L, 32L, 37K, 50R, 51E, 54E, 55E, 71F, 79L, 81M, 97S, 98E, 115W, 117G
CDD
cd03427 (MTH1)

115W

putative active site
1M, 3T, 5L, 32L, 37K, 50R, 51E, 54E, 55E, 71F, 79L, 81M, 97S, 98E, 115W, 117G
CDD
cd03427 (MTH1)

117G

putative active site
1M, 3T, 5L, 32L, 37K, 50R, 51E, 54E, 55E, 71F, 79L, 81M, 97S, 98E, 115W, 117G
CDD
cd03427 (MTH1)
nucleotide binding...

1M

nucleotide binding site
1M, 3T, 5L, 32L, 37K, 50R, 51E, 54E, 55E, 71F, 79L, 81M, 115W, 117G
CDD
cd03427 (MTH1)

3T

nucleotide binding site
1M, 3T, 5L, 32L, 37K, 50R, 51E, 54E, 55E, 71F, 79L, 81M, 115W, 117G
CDD
cd03427 (MTH1)

5L

nucleotide binding site
1M, 3T, 5L, 32L, 37K, 50R, 51E, 54E, 55E, 71F, 79L, 81M, 115W, 117G
CDD
cd03427 (MTH1)

32L

nucleotide binding site
1M, 3T, 5L, 32L, 37K, 50R, 51E, 54E, 55E, 71F, 79L, 81M, 115W, 117G
CDD
cd03427 (MTH1)

37K

nucleotide binding site
1M, 3T, 5L, 32L, 37K, 50R, 51E, 54E, 55E, 71F, 79L, 81M, 115W, 117G
CDD
cd03427 (MTH1)

50R

nucleotide binding site
1M, 3T, 5L, 32L, 37K, 50R, 51E, 54E, 55E, 71F, 79L, 81M, 115W, 117G
CDD
cd03427 (MTH1)

51E

nucleotide binding site
1M, 3T, 5L, 32L, 37K, 50R, 51E, 54E, 55E, 71F, 79L, 81M, 115W, 117G
CDD
cd03427 (MTH1)

54E

nucleotide binding site
1M, 3T, 5L, 32L, 37K, 50R, 51E, 54E, 55E, 71F, 79L, 81M, 115W, 117G
CDD
cd03427 (MTH1)

55E

nucleotide binding site
1M, 3T, 5L, 32L, 37K, 50R, 51E, 54E, 55E, 71F, 79L, 81M, 115W, 117G
CDD
cd03427 (MTH1)

71F

nucleotide binding site
1M, 3T, 5L, 32L, 37K, 50R, 51E, 54E, 55E, 71F, 79L, 81M, 115W, 117G
CDD
cd03427 (MTH1)

79L

nucleotide binding site
1M, 3T, 5L, 32L, 37K, 50R, 51E, 54E, 55E, 71F, 79L, 81M, 115W, 117G
CDD
cd03427 (MTH1)

81M

nucleotide binding site
1M, 3T, 5L, 32L, 37K, 50R, 51E, 54E, 55E, 71F, 79L, 81M, 115W, 117G
CDD
cd03427 (MTH1)

115W

nucleotide binding site
1M, 3T, 5L, 32L, 37K, 50R, 51E, 54E, 55E, 71F, 79L, 81M, 115W, 117G
CDD
cd03427 (MTH1)

117G

nucleotide binding site
1M, 3T, 5L, 32L, 37K, 50R, 51E, 54E, 55E, 71F, 79L, 81M, 115W, 117G
CDD
cd03427 (MTH1)
nudix motif cd03427

36G

nudix motif
36G, 37K, 38L, 39E, 40K, 41S, 42E, 43T, 44P, 45E, 46Q, 47C, 48L, 49F, 50R, 51E, 52V, 53K, 54E, 55E, 56T, 57G, 58L
CDD
cd03427 (MTH1)

37K

nudix motif
36G, 37K, 38L, 39E, 40K, 41S, 42E, 43T, 44P, 45E, 46Q, 47C, 48L, 49F, 50R, 51E, 52V, 53K, 54E, 55E, 56T, 57G, 58L
CDD
cd03427 (MTH1)

38L

nudix motif
36G, 37K, 38L, 39E, 40K, 41S, 42E, 43T, 44P, 45E, 46Q, 47C, 48L, 49F, 50R, 51E, 52V, 53K, 54E, 55E, 56T, 57G, 58L
CDD
cd03427 (MTH1)

39E

nudix motif
36G, 37K, 38L, 39E, 40K, 41S, 42E, 43T, 44P, 45E, 46Q, 47C, 48L, 49F, 50R, 51E, 52V, 53K, 54E, 55E, 56T, 57G, 58L
CDD
cd03427 (MTH1)

40K

nudix motif
36G, 37K, 38L, 39E, 40K, 41S, 42E, 43T, 44P, 45E, 46Q, 47C, 48L, 49F, 50R, 51E, 52V, 53K, 54E, 55E, 56T, 57G, 58L
CDD
cd03427 (MTH1)

41S

nudix motif
36G, 37K, 38L, 39E, 40K, 41S, 42E, 43T, 44P, 45E, 46Q, 47C, 48L, 49F, 50R, 51E, 52V, 53K, 54E, 55E, 56T, 57G, 58L
CDD
cd03427 (MTH1)

42E

nudix motif
36G, 37K, 38L, 39E, 40K, 41S, 42E, 43T, 44P, 45E, 46Q, 47C, 48L, 49F, 50R, 51E, 52V, 53K, 54E, 55E, 56T, 57G, 58L
CDD
cd03427 (MTH1)

43T

nudix motif
36G, 37K, 38L, 39E, 40K, 41S, 42E, 43T, 44P, 45E, 46Q, 47C, 48L, 49F, 50R, 51E, 52V, 53K, 54E, 55E, 56T, 57G, 58L
CDD
cd03427 (MTH1)

44P

nudix motif
36G, 37K, 38L, 39E, 40K, 41S, 42E, 43T, 44P, 45E, 46Q, 47C, 48L, 49F, 50R, 51E, 52V, 53K, 54E, 55E, 56T, 57G, 58L
CDD
cd03427 (MTH1)

45E

nudix motif
36G, 37K, 38L, 39E, 40K, 41S, 42E, 43T, 44P, 45E, 46Q, 47C, 48L, 49F, 50R, 51E, 52V, 53K, 54E, 55E, 56T, 57G, 58L
CDD
cd03427 (MTH1)

46Q

nudix motif
36G, 37K, 38L, 39E, 40K, 41S, 42E, 43T, 44P, 45E, 46Q, 47C, 48L, 49F, 50R, 51E, 52V, 53K, 54E, 55E, 56T, 57G, 58L
CDD
cd03427 (MTH1)

47C

nudix motif
36G, 37K, 38L, 39E, 40K, 41S, 42E, 43T, 44P, 45E, 46Q, 47C, 48L, 49F, 50R, 51E, 52V, 53K, 54E, 55E, 56T, 57G, 58L
CDD
cd03427 (MTH1)

48L

nudix motif
36G, 37K, 38L, 39E, 40K, 41S, 42E, 43T, 44P, 45E, 46Q, 47C, 48L, 49F, 50R, 51E, 52V, 53K, 54E, 55E, 56T, 57G, 58L
CDD
cd03427 (MTH1)

49F

nudix motif
36G, 37K, 38L, 39E, 40K, 41S, 42E, 43T, 44P, 45E, 46Q, 47C, 48L, 49F, 50R, 51E, 52V, 53K, 54E, 55E, 56T, 57G, 58L
CDD
cd03427 (MTH1)

50R

nudix motif
36G, 37K, 38L, 39E, 40K, 41S, 42E, 43T, 44P, 45E, 46Q, 47C, 48L, 49F, 50R, 51E, 52V, 53K, 54E, 55E, 56T, 57G, 58L
CDD
cd03427 (MTH1)

51E

nudix motif
36G, 37K, 38L, 39E, 40K, 41S, 42E, 43T, 44P, 45E, 46Q, 47C, 48L, 49F, 50R, 51E, 52V, 53K, 54E, 55E, 56T, 57G, 58L
CDD
cd03427 (MTH1)

52V

nudix motif
36G, 37K, 38L, 39E, 40K, 41S, 42E, 43T, 44P, 45E, 46Q, 47C, 48L, 49F, 50R, 51E, 52V, 53K, 54E, 55E, 56T, 57G, 58L
CDD
cd03427 (MTH1)

53K

nudix motif
36G, 37K, 38L, 39E, 40K, 41S, 42E, 43T, 44P, 45E, 46Q, 47C, 48L, 49F, 50R, 51E, 52V, 53K, 54E, 55E, 56T, 57G, 58L
CDD
cd03427 (MTH1)

54E

nudix motif
36G, 37K, 38L, 39E, 40K, 41S, 42E, 43T, 44P, 45E, 46Q, 47C, 48L, 49F, 50R, 51E, 52V, 53K, 54E, 55E, 56T, 57G, 58L
CDD
cd03427 (MTH1)

55E

nudix motif
36G, 37K, 38L, 39E, 40K, 41S, 42E, 43T, 44P, 45E, 46Q, 47C, 48L, 49F, 50R, 51E, 52V, 53K, 54E, 55E, 56T, 57G, 58L
CDD
cd03427 (MTH1)

56T

nudix motif
36G, 37K, 38L, 39E, 40K, 41S, 42E, 43T, 44P, 45E, 46Q, 47C, 48L, 49F, 50R, 51E, 52V, 53K, 54E, 55E, 56T, 57G, 58L
CDD
cd03427 (MTH1)

57G

nudix motif
36G, 37K, 38L, 39E, 40K, 41S, 42E, 43T, 44P, 45E, 46Q, 47C, 48L, 49F, 50R, 51E, 52V, 53K, 54E, 55E, 56T, 57G, 58L
CDD
cd03427 (MTH1)

58L

nudix motif
36G, 37K, 38L, 39E, 40K, 41S, 42E, 43T, 44P, 45E, 46Q, 47C, 48L, 49F, 50R, 51E, 52V, 53K, 54E, 55E, 56T, 57G, 58L
CDD
cd03427 (MTH1)
putative metal bin...

97S

putative metal binding site
97S, 98E
CDD
cd03427 (MTH1)

98E

putative metal binding site
97S, 98E
CDD
cd03427 (MTH1)

GO term prediction

Biological Process

GO:0006281 DNA repair

Molecular Function

GO:0008413 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
GO:0016787 hydrolase activity

Cellular Component

None predicted.

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Entry type

Status

Per-residue features

23726_FusoPortal_Gene_278

Protein family membership

Homologous superfamilies

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component