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Protein

23726_FusoPortal_Gene_318

Length

201 amino acids

Protein family membership

GrpE nucleotide exchange factor (IPR000740)

Homologous superfamilies

Homologous superfamily
2 - 143
GrpE nucleotide exchange factor, coiled-coil (IPR013805)
146 - 200
GrpE nucleotide exchange factor, head (IPR009012)

1 20 40 60 80 100 120 140 160 180 201

Domains and repeats

None predicted.

Detailed signature matches

IPR013805

GrpE nucleotide exchange factor, coiled-coil

G3DSA:3.90.20.20

2 - 143

GENE3D
G3DSA:3.90.20.20 (G3DSA:3.90.20.20)

IPR009012

GrpE nucleotide exchange factor, head

SSF51064 (Head doma...)

153 - 200

SUPERFAMILY
SSF51064 (Head domain of nucleotide exchange factor GrpE)
G3DSA:2.30.22.10

146 - 200

GENE3D
G3DSA:2.30.22.10 (G3DSA:2.30.22.10)

IPR000740

GrpE nucleotide exchange factor

MF_01151 (GrpE)

2 - 200

HAMAP
MF_01151 (GrpE)
PR00773 (GRPEPROTEIN)

179 - 198

PRINTS
PR00773 (GRPEPROTEIN)

71 - 87

PRINTS
PR00773 (GRPEPROTEIN)

152 - 167

PRINTS
PR00773 (GRPEPROTEIN)

99 - 114

PRINTS
PR00773 (GRPEPROTEIN)
PTHR21237 (GRPE PRO...)

19 - 200

PANTHER
PTHR21237 (GRPE PROTEIN)
PS01071 (GRPE)

155 - 198

PROSITE patterns
PS01071 (GRPE)
cd00446 (GrpE)

64 - 198

CDD
cd00446 (GrpE)
PF01025 (GrpE)

38 - 200

Pfam
PF01025 (GrpE)

no IPR

Unintegrated signatures

Coil

49 - 76

COILS
Coil (Coil)

1 - 40

COILS
Coil (Coil)
PTHR21237:SF23 (GRP...)

19 - 200

PANTHER
PTHR21237:SF23 (GRPE PROTEIN HOMOLOG, MITOCHONDRIAL)
SSF58014 (Coiled-co...)

51 - 142

SUPERFAMILY
SSF58014 (Coiled-coil domain of nucleotide exchange factor GrpE)

Residue annotation

dimer interface cd...

66W

dimer interface
66W, 69S, 70F, 73K, 74Q, 76D, 77F, 80F, 81T, 82K, 84K, 87E, 88V, 91L, 92K, 95A, 96S, 98K, 99I, 102Q, 103F, 104L, 106S, 107L, 108D, 109N, 110F, 112R, 113A, 129G, 130V, 132M, 133I, 134V, 137L, 143S, 144E
CDD
cd00446 (GrpE)

69S

dimer interface
66W, 69S, 70F, 73K, 74Q, 76D, 77F, 80F, 81T, 82K, 84K, 87E, 88V, 91L, 92K, 95A, 96S, 98K, 99I, 102Q, 103F, 104L, 106S, 107L, 108D, 109N, 110F, 112R, 113A, 129G, 130V, 132M, 133I, 134V, 137L, 143S, 144E
CDD
cd00446 (GrpE)

70F

dimer interface
66W, 69S, 70F, 73K, 74Q, 76D, 77F, 80F, 81T, 82K, 84K, 87E, 88V, 91L, 92K, 95A, 96S, 98K, 99I, 102Q, 103F, 104L, 106S, 107L, 108D, 109N, 110F, 112R, 113A, 129G, 130V, 132M, 133I, 134V, 137L, 143S, 144E
CDD
cd00446 (GrpE)

73K

dimer interface
66W, 69S, 70F, 73K, 74Q, 76D, 77F, 80F, 81T, 82K, 84K, 87E, 88V, 91L, 92K, 95A, 96S, 98K, 99I, 102Q, 103F, 104L, 106S, 107L, 108D, 109N, 110F, 112R, 113A, 129G, 130V, 132M, 133I, 134V, 137L, 143S, 144E
CDD
cd00446 (GrpE)

74Q

dimer interface
66W, 69S, 70F, 73K, 74Q, 76D, 77F, 80F, 81T, 82K, 84K, 87E, 88V, 91L, 92K, 95A, 96S, 98K, 99I, 102Q, 103F, 104L, 106S, 107L, 108D, 109N, 110F, 112R, 113A, 129G, 130V, 132M, 133I, 134V, 137L, 143S, 144E
CDD
cd00446 (GrpE)

76D

dimer interface
66W, 69S, 70F, 73K, 74Q, 76D, 77F, 80F, 81T, 82K, 84K, 87E, 88V, 91L, 92K, 95A, 96S, 98K, 99I, 102Q, 103F, 104L, 106S, 107L, 108D, 109N, 110F, 112R, 113A, 129G, 130V, 132M, 133I, 134V, 137L, 143S, 144E
CDD
cd00446 (GrpE)

77F

dimer interface
66W, 69S, 70F, 73K, 74Q, 76D, 77F, 80F, 81T, 82K, 84K, 87E, 88V, 91L, 92K, 95A, 96S, 98K, 99I, 102Q, 103F, 104L, 106S, 107L, 108D, 109N, 110F, 112R, 113A, 129G, 130V, 132M, 133I, 134V, 137L, 143S, 144E
CDD
cd00446 (GrpE)

80F

dimer interface
66W, 69S, 70F, 73K, 74Q, 76D, 77F, 80F, 81T, 82K, 84K, 87E, 88V, 91L, 92K, 95A, 96S, 98K, 99I, 102Q, 103F, 104L, 106S, 107L, 108D, 109N, 110F, 112R, 113A, 129G, 130V, 132M, 133I, 134V, 137L, 143S, 144E
CDD
cd00446 (GrpE)

81T

dimer interface
66W, 69S, 70F, 73K, 74Q, 76D, 77F, 80F, 81T, 82K, 84K, 87E, 88V, 91L, 92K, 95A, 96S, 98K, 99I, 102Q, 103F, 104L, 106S, 107L, 108D, 109N, 110F, 112R, 113A, 129G, 130V, 132M, 133I, 134V, 137L, 143S, 144E
CDD
cd00446 (GrpE)

82K

dimer interface
66W, 69S, 70F, 73K, 74Q, 76D, 77F, 80F, 81T, 82K, 84K, 87E, 88V, 91L, 92K, 95A, 96S, 98K, 99I, 102Q, 103F, 104L, 106S, 107L, 108D, 109N, 110F, 112R, 113A, 129G, 130V, 132M, 133I, 134V, 137L, 143S, 144E
CDD
cd00446 (GrpE)

84K

dimer interface
66W, 69S, 70F, 73K, 74Q, 76D, 77F, 80F, 81T, 82K, 84K, 87E, 88V, 91L, 92K, 95A, 96S, 98K, 99I, 102Q, 103F, 104L, 106S, 107L, 108D, 109N, 110F, 112R, 113A, 129G, 130V, 132M, 133I, 134V, 137L, 143S, 144E
CDD
cd00446 (GrpE)

87E

dimer interface
66W, 69S, 70F, 73K, 74Q, 76D, 77F, 80F, 81T, 82K, 84K, 87E, 88V, 91L, 92K, 95A, 96S, 98K, 99I, 102Q, 103F, 104L, 106S, 107L, 108D, 109N, 110F, 112R, 113A, 129G, 130V, 132M, 133I, 134V, 137L, 143S, 144E
CDD
cd00446 (GrpE)

88V

dimer interface
66W, 69S, 70F, 73K, 74Q, 76D, 77F, 80F, 81T, 82K, 84K, 87E, 88V, 91L, 92K, 95A, 96S, 98K, 99I, 102Q, 103F, 104L, 106S, 107L, 108D, 109N, 110F, 112R, 113A, 129G, 130V, 132M, 133I, 134V, 137L, 143S, 144E
CDD
cd00446 (GrpE)

91L

dimer interface
66W, 69S, 70F, 73K, 74Q, 76D, 77F, 80F, 81T, 82K, 84K, 87E, 88V, 91L, 92K, 95A, 96S, 98K, 99I, 102Q, 103F, 104L, 106S, 107L, 108D, 109N, 110F, 112R, 113A, 129G, 130V, 132M, 133I, 134V, 137L, 143S, 144E
CDD
cd00446 (GrpE)

92K

dimer interface
66W, 69S, 70F, 73K, 74Q, 76D, 77F, 80F, 81T, 82K, 84K, 87E, 88V, 91L, 92K, 95A, 96S, 98K, 99I, 102Q, 103F, 104L, 106S, 107L, 108D, 109N, 110F, 112R, 113A, 129G, 130V, 132M, 133I, 134V, 137L, 143S, 144E
CDD
cd00446 (GrpE)

95A

dimer interface
66W, 69S, 70F, 73K, 74Q, 76D, 77F, 80F, 81T, 82K, 84K, 87E, 88V, 91L, 92K, 95A, 96S, 98K, 99I, 102Q, 103F, 104L, 106S, 107L, 108D, 109N, 110F, 112R, 113A, 129G, 130V, 132M, 133I, 134V, 137L, 143S, 144E
CDD
cd00446 (GrpE)

96S

dimer interface
66W, 69S, 70F, 73K, 74Q, 76D, 77F, 80F, 81T, 82K, 84K, 87E, 88V, 91L, 92K, 95A, 96S, 98K, 99I, 102Q, 103F, 104L, 106S, 107L, 108D, 109N, 110F, 112R, 113A, 129G, 130V, 132M, 133I, 134V, 137L, 143S, 144E
CDD
cd00446 (GrpE)

98K

dimer interface
66W, 69S, 70F, 73K, 74Q, 76D, 77F, 80F, 81T, 82K, 84K, 87E, 88V, 91L, 92K, 95A, 96S, 98K, 99I, 102Q, 103F, 104L, 106S, 107L, 108D, 109N, 110F, 112R, 113A, 129G, 130V, 132M, 133I, 134V, 137L, 143S, 144E
CDD
cd00446 (GrpE)

99I

dimer interface
66W, 69S, 70F, 73K, 74Q, 76D, 77F, 80F, 81T, 82K, 84K, 87E, 88V, 91L, 92K, 95A, 96S, 98K, 99I, 102Q, 103F, 104L, 106S, 107L, 108D, 109N, 110F, 112R, 113A, 129G, 130V, 132M, 133I, 134V, 137L, 143S, 144E
CDD
cd00446 (GrpE)

102Q

dimer interface
66W, 69S, 70F, 73K, 74Q, 76D, 77F, 80F, 81T, 82K, 84K, 87E, 88V, 91L, 92K, 95A, 96S, 98K, 99I, 102Q, 103F, 104L, 106S, 107L, 108D, 109N, 110F, 112R, 113A, 129G, 130V, 132M, 133I, 134V, 137L, 143S, 144E
CDD
cd00446 (GrpE)

103F

dimer interface
66W, 69S, 70F, 73K, 74Q, 76D, 77F, 80F, 81T, 82K, 84K, 87E, 88V, 91L, 92K, 95A, 96S, 98K, 99I, 102Q, 103F, 104L, 106S, 107L, 108D, 109N, 110F, 112R, 113A, 129G, 130V, 132M, 133I, 134V, 137L, 143S, 144E
CDD
cd00446 (GrpE)

104L

dimer interface
66W, 69S, 70F, 73K, 74Q, 76D, 77F, 80F, 81T, 82K, 84K, 87E, 88V, 91L, 92K, 95A, 96S, 98K, 99I, 102Q, 103F, 104L, 106S, 107L, 108D, 109N, 110F, 112R, 113A, 129G, 130V, 132M, 133I, 134V, 137L, 143S, 144E
CDD
cd00446 (GrpE)

106S

dimer interface
66W, 69S, 70F, 73K, 74Q, 76D, 77F, 80F, 81T, 82K, 84K, 87E, 88V, 91L, 92K, 95A, 96S, 98K, 99I, 102Q, 103F, 104L, 106S, 107L, 108D, 109N, 110F, 112R, 113A, 129G, 130V, 132M, 133I, 134V, 137L, 143S, 144E
CDD
cd00446 (GrpE)

107L

dimer interface
66W, 69S, 70F, 73K, 74Q, 76D, 77F, 80F, 81T, 82K, 84K, 87E, 88V, 91L, 92K, 95A, 96S, 98K, 99I, 102Q, 103F, 104L, 106S, 107L, 108D, 109N, 110F, 112R, 113A, 129G, 130V, 132M, 133I, 134V, 137L, 143S, 144E
CDD
cd00446 (GrpE)

108D

dimer interface
66W, 69S, 70F, 73K, 74Q, 76D, 77F, 80F, 81T, 82K, 84K, 87E, 88V, 91L, 92K, 95A, 96S, 98K, 99I, 102Q, 103F, 104L, 106S, 107L, 108D, 109N, 110F, 112R, 113A, 129G, 130V, 132M, 133I, 134V, 137L, 143S, 144E
CDD
cd00446 (GrpE)

109N

dimer interface
66W, 69S, 70F, 73K, 74Q, 76D, 77F, 80F, 81T, 82K, 84K, 87E, 88V, 91L, 92K, 95A, 96S, 98K, 99I, 102Q, 103F, 104L, 106S, 107L, 108D, 109N, 110F, 112R, 113A, 129G, 130V, 132M, 133I, 134V, 137L, 143S, 144E
CDD
cd00446 (GrpE)

110F

dimer interface
66W, 69S, 70F, 73K, 74Q, 76D, 77F, 80F, 81T, 82K, 84K, 87E, 88V, 91L, 92K, 95A, 96S, 98K, 99I, 102Q, 103F, 104L, 106S, 107L, 108D, 109N, 110F, 112R, 113A, 129G, 130V, 132M, 133I, 134V, 137L, 143S, 144E
CDD
cd00446 (GrpE)

112R

dimer interface
66W, 69S, 70F, 73K, 74Q, 76D, 77F, 80F, 81T, 82K, 84K, 87E, 88V, 91L, 92K, 95A, 96S, 98K, 99I, 102Q, 103F, 104L, 106S, 107L, 108D, 109N, 110F, 112R, 113A, 129G, 130V, 132M, 133I, 134V, 137L, 143S, 144E
CDD
cd00446 (GrpE)

113A

dimer interface
66W, 69S, 70F, 73K, 74Q, 76D, 77F, 80F, 81T, 82K, 84K, 87E, 88V, 91L, 92K, 95A, 96S, 98K, 99I, 102Q, 103F, 104L, 106S, 107L, 108D, 109N, 110F, 112R, 113A, 129G, 130V, 132M, 133I, 134V, 137L, 143S, 144E
CDD
cd00446 (GrpE)

129G

dimer interface
66W, 69S, 70F, 73K, 74Q, 76D, 77F, 80F, 81T, 82K, 84K, 87E, 88V, 91L, 92K, 95A, 96S, 98K, 99I, 102Q, 103F, 104L, 106S, 107L, 108D, 109N, 110F, 112R, 113A, 129G, 130V, 132M, 133I, 134V, 137L, 143S, 144E
CDD
cd00446 (GrpE)

130V

dimer interface
66W, 69S, 70F, 73K, 74Q, 76D, 77F, 80F, 81T, 82K, 84K, 87E, 88V, 91L, 92K, 95A, 96S, 98K, 99I, 102Q, 103F, 104L, 106S, 107L, 108D, 109N, 110F, 112R, 113A, 129G, 130V, 132M, 133I, 134V, 137L, 143S, 144E
CDD
cd00446 (GrpE)

132M

dimer interface
66W, 69S, 70F, 73K, 74Q, 76D, 77F, 80F, 81T, 82K, 84K, 87E, 88V, 91L, 92K, 95A, 96S, 98K, 99I, 102Q, 103F, 104L, 106S, 107L, 108D, 109N, 110F, 112R, 113A, 129G, 130V, 132M, 133I, 134V, 137L, 143S, 144E
CDD
cd00446 (GrpE)

133I

dimer interface
66W, 69S, 70F, 73K, 74Q, 76D, 77F, 80F, 81T, 82K, 84K, 87E, 88V, 91L, 92K, 95A, 96S, 98K, 99I, 102Q, 103F, 104L, 106S, 107L, 108D, 109N, 110F, 112R, 113A, 129G, 130V, 132M, 133I, 134V, 137L, 143S, 144E
CDD
cd00446 (GrpE)

134V

dimer interface
66W, 69S, 70F, 73K, 74Q, 76D, 77F, 80F, 81T, 82K, 84K, 87E, 88V, 91L, 92K, 95A, 96S, 98K, 99I, 102Q, 103F, 104L, 106S, 107L, 108D, 109N, 110F, 112R, 113A, 129G, 130V, 132M, 133I, 134V, 137L, 143S, 144E
CDD
cd00446 (GrpE)

137L

dimer interface
66W, 69S, 70F, 73K, 74Q, 76D, 77F, 80F, 81T, 82K, 84K, 87E, 88V, 91L, 92K, 95A, 96S, 98K, 99I, 102Q, 103F, 104L, 106S, 107L, 108D, 109N, 110F, 112R, 113A, 129G, 130V, 132M, 133I, 134V, 137L, 143S, 144E
CDD
cd00446 (GrpE)

143S

dimer interface
66W, 69S, 70F, 73K, 74Q, 76D, 77F, 80F, 81T, 82K, 84K, 87E, 88V, 91L, 92K, 95A, 96S, 98K, 99I, 102Q, 103F, 104L, 106S, 107L, 108D, 109N, 110F, 112R, 113A, 129G, 130V, 132M, 133I, 134V, 137L, 143S, 144E
CDD
cd00446 (GrpE)

144E

dimer interface
66W, 69S, 70F, 73K, 74Q, 76D, 77F, 80F, 81T, 82K, 84K, 87E, 88V, 91L, 92K, 95A, 96S, 98K, 99I, 102Q, 103F, 104L, 106S, 107L, 108D, 109N, 110F, 112R, 113A, 129G, 130V, 132M, 133I, 134V, 137L, 143S, 144E
CDD
cd00446 (GrpE)
Hsp70 (ATPase doma...

82K

Hsp70 (ATPase domain) interactions
82K, 90E, 112R, 115E, 155F, 157P, 158E, 160H, 161H, 162A, 163V, 164G, 180L, 189K, 193P, 195M, 198V
CDD
cd00446 (GrpE)

90E

Hsp70 (ATPase domain) interactions
82K, 90E, 112R, 115E, 155F, 157P, 158E, 160H, 161H, 162A, 163V, 164G, 180L, 189K, 193P, 195M, 198V
CDD
cd00446 (GrpE)

112R

Hsp70 (ATPase domain) interactions
82K, 90E, 112R, 115E, 155F, 157P, 158E, 160H, 161H, 162A, 163V, 164G, 180L, 189K, 193P, 195M, 198V
CDD
cd00446 (GrpE)

115E

Hsp70 (ATPase domain) interactions
82K, 90E, 112R, 115E, 155F, 157P, 158E, 160H, 161H, 162A, 163V, 164G, 180L, 189K, 193P, 195M, 198V
CDD
cd00446 (GrpE)

155F

Hsp70 (ATPase domain) interactions
82K, 90E, 112R, 115E, 155F, 157P, 158E, 160H, 161H, 162A, 163V, 164G, 180L, 189K, 193P, 195M, 198V
CDD
cd00446 (GrpE)

157P

Hsp70 (ATPase domain) interactions
82K, 90E, 112R, 115E, 155F, 157P, 158E, 160H, 161H, 162A, 163V, 164G, 180L, 189K, 193P, 195M, 198V
CDD
cd00446 (GrpE)

158E

Hsp70 (ATPase domain) interactions
82K, 90E, 112R, 115E, 155F, 157P, 158E, 160H, 161H, 162A, 163V, 164G, 180L, 189K, 193P, 195M, 198V
CDD
cd00446 (GrpE)

160H

Hsp70 (ATPase domain) interactions
82K, 90E, 112R, 115E, 155F, 157P, 158E, 160H, 161H, 162A, 163V, 164G, 180L, 189K, 193P, 195M, 198V
CDD
cd00446 (GrpE)

161H

Hsp70 (ATPase domain) interactions
82K, 90E, 112R, 115E, 155F, 157P, 158E, 160H, 161H, 162A, 163V, 164G, 180L, 189K, 193P, 195M, 198V
CDD
cd00446 (GrpE)

162A

Hsp70 (ATPase domain) interactions
82K, 90E, 112R, 115E, 155F, 157P, 158E, 160H, 161H, 162A, 163V, 164G, 180L, 189K, 193P, 195M, 198V
CDD
cd00446 (GrpE)

163V

Hsp70 (ATPase domain) interactions
82K, 90E, 112R, 115E, 155F, 157P, 158E, 160H, 161H, 162A, 163V, 164G, 180L, 189K, 193P, 195M, 198V
CDD
cd00446 (GrpE)

164G

Hsp70 (ATPase domain) interactions
82K, 90E, 112R, 115E, 155F, 157P, 158E, 160H, 161H, 162A, 163V, 164G, 180L, 189K, 193P, 195M, 198V
CDD
cd00446 (GrpE)

180L

Hsp70 (ATPase domain) interactions
82K, 90E, 112R, 115E, 155F, 157P, 158E, 160H, 161H, 162A, 163V, 164G, 180L, 189K, 193P, 195M, 198V
CDD
cd00446 (GrpE)

189K

Hsp70 (ATPase domain) interactions
82K, 90E, 112R, 115E, 155F, 157P, 158E, 160H, 161H, 162A, 163V, 164G, 180L, 189K, 193P, 195M, 198V
CDD
cd00446 (GrpE)

193P

Hsp70 (ATPase domain) interactions
82K, 90E, 112R, 115E, 155F, 157P, 158E, 160H, 161H, 162A, 163V, 164G, 180L, 189K, 193P, 195M, 198V
CDD
cd00446 (GrpE)

195M

Hsp70 (ATPase domain) interactions
82K, 90E, 112R, 115E, 155F, 157P, 158E, 160H, 161H, 162A, 163V, 164G, 180L, 189K, 193P, 195M, 198V
CDD
cd00446 (GrpE)

198V

Hsp70 (ATPase domain) interactions
82K, 90E, 112R, 115E, 155F, 157P, 158E, 160H, 161H, 162A, 163V, 164G, 180L, 189K, 193P, 195M, 198V
CDD
cd00446 (GrpE)

GO term prediction

Biological Process

GO:0006457 protein folding

Molecular Function

GO:0000774 adenyl-nucleotide exchange factor activity
GO:0042803 protein homodimerization activity
GO:0051087 chaperone binding

Cellular Component