23726_FusoPortal_Gene_412

Protein

23726_FusoPortal_Gene_412

Length

329 amino acids

Protein family membership

UDP-glucose 4-epimerase (IPR005886)

Homologous superfamilies

Homologous superfamily
1 - 328
NAD(P)-binding domain superfamily (IPR036291)

1 50 100 150 200 250 300 329

Domains and repeats

Domain
3 - 252
NAD-dependent epimerase/dehydratase (IPR001509)

1 50 100 150 200 250 300 329

Detailed signature matches

IPR036291

NAD(P)-binding domain superfamily
1. SSF51735 (NAD(P)-bi...)
  
  1 - 328
  
  SUPERFAMILY
  SSF51735 (NAD(P)-binding Rossmann-fold domains)
IPR005886

UDP-glucose 4-epimerase
1. TIGR01179
  
  3 - 326
  
  TIGRFAMs
  TIGR01179 (TIGR01179)
2. cd05247 (UDP_G4E_1_...)
  
  3 - 321
  
  CDD
  cd05247 (UDP_G4E_1_SDR_e)
IPR001509

NAD-dependent epimerase/dehydratase
1. PF01370 (Epimerase)
  
  3 - 252
  
  Pfam
  PF01370 (Epimerase)

no IPR

Unintegrated signatures

G3DSA:3.40.50...

1 - 164

GENE3D
G3DSA:3.40.50.720 (G3DSA:3.40.50.720)
G3DSA:3.90.25.10

165 - 329

GENE3D
G3DSA:3.90.25.10 (G3DSA:3.90.25.10)
PTHR43349 (FAMILY N...)

2 - 325

PANTHER
PTHR43349 (FAMILY NOT NAMED)
PTHR43349:SF11 (UDP...)

2 - 325

PANTHER
PTHR43349:SF11 (UDP-ARABINOSE 4-EPIMERASE 1-RELATED)

Residue annotation

NAD binding site c...

7G

NAD binding site
7G, 9A, 10G, 11Y, 12I, 31D, 32S, 33L, 34I, 35T, 36G, 50G, 51D, 52L, 73F, 74A, 75A, 77S, 92N, 115S, 116S, 117T, 141Y, 145K, 168Y, 169F, 171V
CDD
cd05247 (UDP_G4E_1_SDR_e)

9A

NAD binding site
7G, 9A, 10G, 11Y, 12I, 31D, 32S, 33L, 34I, 35T, 36G, 50G, 51D, 52L, 73F, 74A, 75A, 77S, 92N, 115S, 116S, 117T, 141Y, 145K, 168Y, 169F, 171V
CDD
cd05247 (UDP_G4E_1_SDR_e)

10G

NAD binding site
7G, 9A, 10G, 11Y, 12I, 31D, 32S, 33L, 34I, 35T, 36G, 50G, 51D, 52L, 73F, 74A, 75A, 77S, 92N, 115S, 116S, 117T, 141Y, 145K, 168Y, 169F, 171V
CDD
cd05247 (UDP_G4E_1_SDR_e)

11Y

NAD binding site
7G, 9A, 10G, 11Y, 12I, 31D, 32S, 33L, 34I, 35T, 36G, 50G, 51D, 52L, 73F, 74A, 75A, 77S, 92N, 115S, 116S, 117T, 141Y, 145K, 168Y, 169F, 171V
CDD
cd05247 (UDP_G4E_1_SDR_e)

12I

NAD binding site
7G, 9A, 10G, 11Y, 12I, 31D, 32S, 33L, 34I, 35T, 36G, 50G, 51D, 52L, 73F, 74A, 75A, 77S, 92N, 115S, 116S, 117T, 141Y, 145K, 168Y, 169F, 171V
CDD
cd05247 (UDP_G4E_1_SDR_e)

31D

NAD binding site
7G, 9A, 10G, 11Y, 12I, 31D, 32S, 33L, 34I, 35T, 36G, 50G, 51D, 52L, 73F, 74A, 75A, 77S, 92N, 115S, 116S, 117T, 141Y, 145K, 168Y, 169F, 171V
CDD
cd05247 (UDP_G4E_1_SDR_e)

32S

NAD binding site
7G, 9A, 10G, 11Y, 12I, 31D, 32S, 33L, 34I, 35T, 36G, 50G, 51D, 52L, 73F, 74A, 75A, 77S, 92N, 115S, 116S, 117T, 141Y, 145K, 168Y, 169F, 171V
CDD
cd05247 (UDP_G4E_1_SDR_e)

33L

NAD binding site
7G, 9A, 10G, 11Y, 12I, 31D, 32S, 33L, 34I, 35T, 36G, 50G, 51D, 52L, 73F, 74A, 75A, 77S, 92N, 115S, 116S, 117T, 141Y, 145K, 168Y, 169F, 171V
CDD
cd05247 (UDP_G4E_1_SDR_e)

34I

NAD binding site
7G, 9A, 10G, 11Y, 12I, 31D, 32S, 33L, 34I, 35T, 36G, 50G, 51D, 52L, 73F, 74A, 75A, 77S, 92N, 115S, 116S, 117T, 141Y, 145K, 168Y, 169F, 171V
CDD
cd05247 (UDP_G4E_1_SDR_e)

35T

NAD binding site
7G, 9A, 10G, 11Y, 12I, 31D, 32S, 33L, 34I, 35T, 36G, 50G, 51D, 52L, 73F, 74A, 75A, 77S, 92N, 115S, 116S, 117T, 141Y, 145K, 168Y, 169F, 171V
CDD
cd05247 (UDP_G4E_1_SDR_e)

36G

NAD binding site
7G, 9A, 10G, 11Y, 12I, 31D, 32S, 33L, 34I, 35T, 36G, 50G, 51D, 52L, 73F, 74A, 75A, 77S, 92N, 115S, 116S, 117T, 141Y, 145K, 168Y, 169F, 171V
CDD
cd05247 (UDP_G4E_1_SDR_e)

50G

NAD binding site
7G, 9A, 10G, 11Y, 12I, 31D, 32S, 33L, 34I, 35T, 36G, 50G, 51D, 52L, 73F, 74A, 75A, 77S, 92N, 115S, 116S, 117T, 141Y, 145K, 168Y, 169F, 171V
CDD
cd05247 (UDP_G4E_1_SDR_e)

51D

NAD binding site
7G, 9A, 10G, 11Y, 12I, 31D, 32S, 33L, 34I, 35T, 36G, 50G, 51D, 52L, 73F, 74A, 75A, 77S, 92N, 115S, 116S, 117T, 141Y, 145K, 168Y, 169F, 171V
CDD
cd05247 (UDP_G4E_1_SDR_e)

52L

NAD binding site
7G, 9A, 10G, 11Y, 12I, 31D, 32S, 33L, 34I, 35T, 36G, 50G, 51D, 52L, 73F, 74A, 75A, 77S, 92N, 115S, 116S, 117T, 141Y, 145K, 168Y, 169F, 171V
CDD
cd05247 (UDP_G4E_1_SDR_e)

73F

NAD binding site
7G, 9A, 10G, 11Y, 12I, 31D, 32S, 33L, 34I, 35T, 36G, 50G, 51D, 52L, 73F, 74A, 75A, 77S, 92N, 115S, 116S, 117T, 141Y, 145K, 168Y, 169F, 171V
CDD
cd05247 (UDP_G4E_1_SDR_e)

74A

NAD binding site
7G, 9A, 10G, 11Y, 12I, 31D, 32S, 33L, 34I, 35T, 36G, 50G, 51D, 52L, 73F, 74A, 75A, 77S, 92N, 115S, 116S, 117T, 141Y, 145K, 168Y, 169F, 171V
CDD
cd05247 (UDP_G4E_1_SDR_e)

75A

NAD binding site
7G, 9A, 10G, 11Y, 12I, 31D, 32S, 33L, 34I, 35T, 36G, 50G, 51D, 52L, 73F, 74A, 75A, 77S, 92N, 115S, 116S, 117T, 141Y, 145K, 168Y, 169F, 171V
CDD
cd05247 (UDP_G4E_1_SDR_e)

77S

NAD binding site
7G, 9A, 10G, 11Y, 12I, 31D, 32S, 33L, 34I, 35T, 36G, 50G, 51D, 52L, 73F, 74A, 75A, 77S, 92N, 115S, 116S, 117T, 141Y, 145K, 168Y, 169F, 171V
CDD
cd05247 (UDP_G4E_1_SDR_e)

92N

NAD binding site
7G, 9A, 10G, 11Y, 12I, 31D, 32S, 33L, 34I, 35T, 36G, 50G, 51D, 52L, 73F, 74A, 75A, 77S, 92N, 115S, 116S, 117T, 141Y, 145K, 168Y, 169F, 171V
CDD
cd05247 (UDP_G4E_1_SDR_e)

115S

NAD binding site
7G, 9A, 10G, 11Y, 12I, 31D, 32S, 33L, 34I, 35T, 36G, 50G, 51D, 52L, 73F, 74A, 75A, 77S, 92N, 115S, 116S, 117T, 141Y, 145K, 168Y, 169F, 171V
CDD
cd05247 (UDP_G4E_1_SDR_e)

116S

NAD binding site
7G, 9A, 10G, 11Y, 12I, 31D, 32S, 33L, 34I, 35T, 36G, 50G, 51D, 52L, 73F, 74A, 75A, 77S, 92N, 115S, 116S, 117T, 141Y, 145K, 168Y, 169F, 171V
CDD
cd05247 (UDP_G4E_1_SDR_e)

117T

NAD binding site
7G, 9A, 10G, 11Y, 12I, 31D, 32S, 33L, 34I, 35T, 36G, 50G, 51D, 52L, 73F, 74A, 75A, 77S, 92N, 115S, 116S, 117T, 141Y, 145K, 168Y, 169F, 171V
CDD
cd05247 (UDP_G4E_1_SDR_e)

141Y

NAD binding site
7G, 9A, 10G, 11Y, 12I, 31D, 32S, 33L, 34I, 35T, 36G, 50G, 51D, 52L, 73F, 74A, 75A, 77S, 92N, 115S, 116S, 117T, 141Y, 145K, 168Y, 169F, 171V
CDD
cd05247 (UDP_G4E_1_SDR_e)

145K

NAD binding site
7G, 9A, 10G, 11Y, 12I, 31D, 32S, 33L, 34I, 35T, 36G, 50G, 51D, 52L, 73F, 74A, 75A, 77S, 92N, 115S, 116S, 117T, 141Y, 145K, 168Y, 169F, 171V
CDD
cd05247 (UDP_G4E_1_SDR_e)

168Y

NAD binding site
7G, 9A, 10G, 11Y, 12I, 31D, 32S, 33L, 34I, 35T, 36G, 50G, 51D, 52L, 73F, 74A, 75A, 77S, 92N, 115S, 116S, 117T, 141Y, 145K, 168Y, 169F, 171V
CDD
cd05247 (UDP_G4E_1_SDR_e)

169F

NAD binding site
7G, 9A, 10G, 11Y, 12I, 31D, 32S, 33L, 34I, 35T, 36G, 50G, 51D, 52L, 73F, 74A, 75A, 77S, 92N, 115S, 116S, 117T, 141Y, 145K, 168Y, 169F, 171V
CDD
cd05247 (UDP_G4E_1_SDR_e)

171V

NAD binding site
7G, 9A, 10G, 11Y, 12I, 31D, 32S, 33L, 34I, 35T, 36G, 50G, 51D, 52L, 73F, 74A, 75A, 77S, 92N, 115S, 116S, 117T, 141Y, 145K, 168Y, 169F, 171V
CDD
cd05247 (UDP_G4E_1_SDR_e)
homodimer interfac...

83V

homodimer interface
83V, 85E, 86P, 87L, 90F, 91E, 94F, 95Y, 98L, 99C, 101L, 102K, 105K, 140P, 143E, 147A, 150K, 151M, 153K, 154W, 155C
CDD
cd05247 (UDP_G4E_1_SDR_e)

85E

homodimer interface
83V, 85E, 86P, 87L, 90F, 91E, 94F, 95Y, 98L, 99C, 101L, 102K, 105K, 140P, 143E, 147A, 150K, 151M, 153K, 154W, 155C
CDD
cd05247 (UDP_G4E_1_SDR_e)

86P

homodimer interface
83V, 85E, 86P, 87L, 90F, 91E, 94F, 95Y, 98L, 99C, 101L, 102K, 105K, 140P, 143E, 147A, 150K, 151M, 153K, 154W, 155C
CDD
cd05247 (UDP_G4E_1_SDR_e)

87L

homodimer interface
83V, 85E, 86P, 87L, 90F, 91E, 94F, 95Y, 98L, 99C, 101L, 102K, 105K, 140P, 143E, 147A, 150K, 151M, 153K, 154W, 155C
CDD
cd05247 (UDP_G4E_1_SDR_e)

90F

homodimer interface
83V, 85E, 86P, 87L, 90F, 91E, 94F, 95Y, 98L, 99C, 101L, 102K, 105K, 140P, 143E, 147A, 150K, 151M, 153K, 154W, 155C
CDD
cd05247 (UDP_G4E_1_SDR_e)

91E

homodimer interface
83V, 85E, 86P, 87L, 90F, 91E, 94F, 95Y, 98L, 99C, 101L, 102K, 105K, 140P, 143E, 147A, 150K, 151M, 153K, 154W, 155C
CDD
cd05247 (UDP_G4E_1_SDR_e)

94F

homodimer interface
83V, 85E, 86P, 87L, 90F, 91E, 94F, 95Y, 98L, 99C, 101L, 102K, 105K, 140P, 143E, 147A, 150K, 151M, 153K, 154W, 155C
CDD
cd05247 (UDP_G4E_1_SDR_e)

95Y

homodimer interface
83V, 85E, 86P, 87L, 90F, 91E, 94F, 95Y, 98L, 99C, 101L, 102K, 105K, 140P, 143E, 147A, 150K, 151M, 153K, 154W, 155C
CDD
cd05247 (UDP_G4E_1_SDR_e)

98L

homodimer interface
83V, 85E, 86P, 87L, 90F, 91E, 94F, 95Y, 98L, 99C, 101L, 102K, 105K, 140P, 143E, 147A, 150K, 151M, 153K, 154W, 155C
CDD
cd05247 (UDP_G4E_1_SDR_e)

99C

homodimer interface
83V, 85E, 86P, 87L, 90F, 91E, 94F, 95Y, 98L, 99C, 101L, 102K, 105K, 140P, 143E, 147A, 150K, 151M, 153K, 154W, 155C
CDD
cd05247 (UDP_G4E_1_SDR_e)

101L

homodimer interface
83V, 85E, 86P, 87L, 90F, 91E, 94F, 95Y, 98L, 99C, 101L, 102K, 105K, 140P, 143E, 147A, 150K, 151M, 153K, 154W, 155C
CDD
cd05247 (UDP_G4E_1_SDR_e)

102K

homodimer interface
83V, 85E, 86P, 87L, 90F, 91E, 94F, 95Y, 98L, 99C, 101L, 102K, 105K, 140P, 143E, 147A, 150K, 151M, 153K, 154W, 155C
CDD
cd05247 (UDP_G4E_1_SDR_e)

105K

homodimer interface
83V, 85E, 86P, 87L, 90F, 91E, 94F, 95Y, 98L, 99C, 101L, 102K, 105K, 140P, 143E, 147A, 150K, 151M, 153K, 154W, 155C
CDD
cd05247 (UDP_G4E_1_SDR_e)

140P

homodimer interface
83V, 85E, 86P, 87L, 90F, 91E, 94F, 95Y, 98L, 99C, 101L, 102K, 105K, 140P, 143E, 147A, 150K, 151M, 153K, 154W, 155C
CDD
cd05247 (UDP_G4E_1_SDR_e)

143E

homodimer interface
83V, 85E, 86P, 87L, 90F, 91E, 94F, 95Y, 98L, 99C, 101L, 102K, 105K, 140P, 143E, 147A, 150K, 151M, 153K, 154W, 155C
CDD
cd05247 (UDP_G4E_1_SDR_e)

147A

homodimer interface
83V, 85E, 86P, 87L, 90F, 91E, 94F, 95Y, 98L, 99C, 101L, 102K, 105K, 140P, 143E, 147A, 150K, 151M, 153K, 154W, 155C
CDD
cd05247 (UDP_G4E_1_SDR_e)

150K

homodimer interface
83V, 85E, 86P, 87L, 90F, 91E, 94F, 95Y, 98L, 99C, 101L, 102K, 105K, 140P, 143E, 147A, 150K, 151M, 153K, 154W, 155C
CDD
cd05247 (UDP_G4E_1_SDR_e)

151M

homodimer interface
83V, 85E, 86P, 87L, 90F, 91E, 94F, 95Y, 98L, 99C, 101L, 102K, 105K, 140P, 143E, 147A, 150K, 151M, 153K, 154W, 155C
CDD
cd05247 (UDP_G4E_1_SDR_e)

153K

homodimer interface
83V, 85E, 86P, 87L, 90F, 91E, 94F, 95Y, 98L, 99C, 101L, 102K, 105K, 140P, 143E, 147A, 150K, 151M, 153K, 154W, 155C
CDD
cd05247 (UDP_G4E_1_SDR_e)

154W

homodimer interface
83V, 85E, 86P, 87L, 90F, 91E, 94F, 95Y, 98L, 99C, 101L, 102K, 105K, 140P, 143E, 147A, 150K, 151M, 153K, 154W, 155C
CDD
cd05247 (UDP_G4E_1_SDR_e)

155C

homodimer interface
83V, 85E, 86P, 87L, 90F, 91E, 94F, 95Y, 98L, 99C, 101L, 102K, 105K, 140P, 143E, 147A, 150K, 151M, 153K, 154W, 155C
CDD
cd05247 (UDP_G4E_1_SDR_e)
active site cd05247

93N

active site
93N, 117T, 141Y, 145K
CDD
cd05247 (UDP_G4E_1_SDR_e)

117T

active site
93N, 117T, 141Y, 145K
CDD
cd05247 (UDP_G4E_1_SDR_e)

141Y

active site
93N, 117T, 141Y, 145K
CDD
cd05247 (UDP_G4E_1_SDR_e)

145K

active site
93N, 117T, 141Y, 145K
CDD
cd05247 (UDP_G4E_1_SDR_e)
substrate binding ...

117T

substrate binding site
117T, 118A, 119A, 141Y, 168Y, 169F, 170N, 188T, 189H, 190L, 205I, 206S, 207I, 208Y, 219C, 221R, 223Y, 259V, 282R, 285D
CDD
cd05247 (UDP_G4E_1_SDR_e)

118A

substrate binding site
117T, 118A, 119A, 141Y, 168Y, 169F, 170N, 188T, 189H, 190L, 205I, 206S, 207I, 208Y, 219C, 221R, 223Y, 259V, 282R, 285D
CDD
cd05247 (UDP_G4E_1_SDR_e)

119A

substrate binding site
117T, 118A, 119A, 141Y, 168Y, 169F, 170N, 188T, 189H, 190L, 205I, 206S, 207I, 208Y, 219C, 221R, 223Y, 259V, 282R, 285D
CDD
cd05247 (UDP_G4E_1_SDR_e)

141Y

substrate binding site
117T, 118A, 119A, 141Y, 168Y, 169F, 170N, 188T, 189H, 190L, 205I, 206S, 207I, 208Y, 219C, 221R, 223Y, 259V, 282R, 285D
CDD
cd05247 (UDP_G4E_1_SDR_e)

168Y

substrate binding site
117T, 118A, 119A, 141Y, 168Y, 169F, 170N, 188T, 189H, 190L, 205I, 206S, 207I, 208Y, 219C, 221R, 223Y, 259V, 282R, 285D
CDD
cd05247 (UDP_G4E_1_SDR_e)

169F

substrate binding site
117T, 118A, 119A, 141Y, 168Y, 169F, 170N, 188T, 189H, 190L, 205I, 206S, 207I, 208Y, 219C, 221R, 223Y, 259V, 282R, 285D
CDD
cd05247 (UDP_G4E_1_SDR_e)

170N

substrate binding site
117T, 118A, 119A, 141Y, 168Y, 169F, 170N, 188T, 189H, 190L, 205I, 206S, 207I, 208Y, 219C, 221R, 223Y, 259V, 282R, 285D
CDD
cd05247 (UDP_G4E_1_SDR_e)

188T

substrate binding site
117T, 118A, 119A, 141Y, 168Y, 169F, 170N, 188T, 189H, 190L, 205I, 206S, 207I, 208Y, 219C, 221R, 223Y, 259V, 282R, 285D
CDD
cd05247 (UDP_G4E_1_SDR_e)

189H

substrate binding site
117T, 118A, 119A, 141Y, 168Y, 169F, 170N, 188T, 189H, 190L, 205I, 206S, 207I, 208Y, 219C, 221R, 223Y, 259V, 282R, 285D
CDD
cd05247 (UDP_G4E_1_SDR_e)

190L

substrate binding site
117T, 118A, 119A, 141Y, 168Y, 169F, 170N, 188T, 189H, 190L, 205I, 206S, 207I, 208Y, 219C, 221R, 223Y, 259V, 282R, 285D
CDD
cd05247 (UDP_G4E_1_SDR_e)

205I

substrate binding site
117T, 118A, 119A, 141Y, 168Y, 169F, 170N, 188T, 189H, 190L, 205I, 206S, 207I, 208Y, 219C, 221R, 223Y, 259V, 282R, 285D
CDD
cd05247 (UDP_G4E_1_SDR_e)

206S

substrate binding site
117T, 118A, 119A, 141Y, 168Y, 169F, 170N, 188T, 189H, 190L, 205I, 206S, 207I, 208Y, 219C, 221R, 223Y, 259V, 282R, 285D
CDD
cd05247 (UDP_G4E_1_SDR_e)

207I

substrate binding site
117T, 118A, 119A, 141Y, 168Y, 169F, 170N, 188T, 189H, 190L, 205I, 206S, 207I, 208Y, 219C, 221R, 223Y, 259V, 282R, 285D
CDD
cd05247 (UDP_G4E_1_SDR_e)

208Y

substrate binding site
117T, 118A, 119A, 141Y, 168Y, 169F, 170N, 188T, 189H, 190L, 205I, 206S, 207I, 208Y, 219C, 221R, 223Y, 259V, 282R, 285D
CDD
cd05247 (UDP_G4E_1_SDR_e)

219C

substrate binding site
117T, 118A, 119A, 141Y, 168Y, 169F, 170N, 188T, 189H, 190L, 205I, 206S, 207I, 208Y, 219C, 221R, 223Y, 259V, 282R, 285D
CDD
cd05247 (UDP_G4E_1_SDR_e)

221R

substrate binding site
117T, 118A, 119A, 141Y, 168Y, 169F, 170N, 188T, 189H, 190L, 205I, 206S, 207I, 208Y, 219C, 221R, 223Y, 259V, 282R, 285D
CDD
cd05247 (UDP_G4E_1_SDR_e)

223Y

substrate binding site
117T, 118A, 119A, 141Y, 168Y, 169F, 170N, 188T, 189H, 190L, 205I, 206S, 207I, 208Y, 219C, 221R, 223Y, 259V, 282R, 285D
CDD
cd05247 (UDP_G4E_1_SDR_e)

259V

substrate binding site
117T, 118A, 119A, 141Y, 168Y, 169F, 170N, 188T, 189H, 190L, 205I, 206S, 207I, 208Y, 219C, 221R, 223Y, 259V, 282R, 285D
CDD
cd05247 (UDP_G4E_1_SDR_e)

282R

substrate binding site
117T, 118A, 119A, 141Y, 168Y, 169F, 170N, 188T, 189H, 190L, 205I, 206S, 207I, 208Y, 219C, 221R, 223Y, 259V, 282R, 285D
CDD
cd05247 (UDP_G4E_1_SDR_e)

285D

substrate binding site
117T, 118A, 119A, 141Y, 168Y, 169F, 170N, 188T, 189H, 190L, 205I, 206S, 207I, 208Y, 219C, 221R, 223Y, 259V, 282R, 285D
CDD
cd05247 (UDP_G4E_1_SDR_e)

GO term prediction

Biological Process

GO:0006012 galactose metabolic process

Molecular Function

GO:0003824 catalytic activity
GO:0003978 UDP-glucose 4-epimerase activity
GO:0050662 coenzyme binding

Cellular Component

None predicted.

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Entry type

Status

Per-residue features

23726_FusoPortal_Gene_412

Protein family membership

Homologous superfamilies

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component