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Protein

23726_FusoPortal_Gene_481

Length

253 amino acids

Protein family membership

AP endonuclease 1 (IPR004808)

Homologous superfamilies

Homologous superfamily

1 50 100 150 200 253

Domains and repeats

Domain

1 50 100 150 200 253

Detailed signature matches

IPR036691

Endonuclease/exonuclease/phosphatase superfamily

SSF56219 (DNase I-like)
G3DSA:3.60.10.10

IPR004808

AP endonuclease 1

PS51435 (AP_NUCLEAS...)
TIGR00633
PTHR22748 (AP ENDON...)

IPR005135

Endonuclease/exonuclease/phosphatase

PF03372 (Exo_endo_phos)

IPR020847

AP endonuclease 1, binding site

PS00726 (AP_NUCLEAS...)

IPR020848

AP endonuclease 1, conserved site

PS00728 (AP_NUCLEAS...)

no IPR

Unintegrated signatures

PTHR22748:SF6 (DNA-...)
TIGR00195
cd09087 (Ape1-like_...)

Residue annotation

putative phosphate...
DNA binding site c...

211A

DNA binding site
7N, 9N, 10G, 11I, 12R, 13A, 17K, 35E, 37K, 42Q, 61G, 62Y, 105Y, 108N, 144D, 146N, 156N, 158K, 160N, 163N, 164A, 199W, 201S, 202Y, 203R, 209N, 211A, 213W, 215I, 242H
CDD
cd09087 (Ape1-like_AP-endo)

213W

DNA binding site
7N, 9N, 10G, 11I, 12R, 13A, 17K, 35E, 37K, 42Q, 61G, 62Y, 105Y, 108N, 144D, 146N, 156N, 158K, 160N, 163N, 164A, 199W, 201S, 202Y, 203R, 209N, 211A, 213W, 215I, 242H
CDD
cd09087 (Ape1-like_AP-endo)

215I

DNA binding site
7N, 9N, 10G, 11I, 12R, 13A, 17K, 35E, 37K, 42Q, 61G, 62Y, 105Y, 108N, 144D, 146N, 156N, 158K, 160N, 163N, 164A, 199W, 201S, 202Y, 203R, 209N, 211A, 213W, 215I, 242H
CDD
cd09087 (Ape1-like_AP-endo)

242H

DNA binding site
7N, 9N, 10G, 11I, 12R, 13A, 17K, 35E, 37K, 42Q, 61G, 62Y, 105Y, 108N, 144D, 146N, 156N, 158K, 160N, 163N, 164A, 199W, 201S, 202Y, 203R, 209N, 211A, 213W, 215I, 242H
CDD
cd09087 (Ape1-like_AP-endo)
putative catalytic...

7N

putative catalytic site
7N, 35E, 105Y, 144D, 146N, 216D, 241D, 242H
CDD
cd09087 (Ape1-like_AP-endo)

35E

putative catalytic site
7N, 35E, 105Y, 144D, 146N, 216D, 241D, 242H
CDD
cd09087 (Ape1-like_AP-endo)

105Y

putative catalytic site
7N, 35E, 105Y, 144D, 146N, 216D, 241D, 242H
CDD
cd09087 (Ape1-like_AP-endo)

144D

putative catalytic site
7N, 35E, 105Y, 144D, 146N, 216D, 241D, 242H
CDD
cd09087 (Ape1-like_AP-endo)

146N

putative catalytic site
7N, 35E, 105Y, 144D, 146N, 216D, 241D, 242H
CDD
cd09087 (Ape1-like_AP-endo)

216D

putative catalytic site
7N, 35E, 105Y, 144D, 146N, 216D, 241D, 242H
CDD
cd09087 (Ape1-like_AP-endo)

241D

putative catalytic site
7N, 35E, 105Y, 144D, 146N, 216D, 241D, 242H
CDD
cd09087 (Ape1-like_AP-endo)

242H

putative catalytic site
7N, 35E, 105Y, 144D, 146N, 216D, 241D, 242H
CDD
cd09087 (Ape1-like_AP-endo)
active site cd09087

7N

active site
7N, 9N, 10G, 11I, 12R, 13A, 17K, 35E, 37K, 42Q, 61G, 62Y, 105Y, 108N, 144D, 146N, 156N, 158K, 160N, 163N, 164A, 199W, 201S, 202Y, 203R, 209N, 211A, 213W, 215I, 216D, 242H
CDD
cd09087 (Ape1-like_AP-endo)

9N

active site
7N, 9N, 10G, 11I, 12R, 13A, 17K, 35E, 37K, 42Q, 61G, 62Y, 105Y, 108N, 144D, 146N, 156N, 158K, 160N, 163N, 164A, 199W, 201S, 202Y, 203R, 209N, 211A, 213W, 215I, 216D, 242H
CDD
cd09087 (Ape1-like_AP-endo)

10G

active site
7N, 9N, 10G, 11I, 12R, 13A, 17K, 35E, 37K, 42Q, 61G, 62Y, 105Y, 108N, 144D, 146N, 156N, 158K, 160N, 163N, 164A, 199W, 201S, 202Y, 203R, 209N, 211A, 213W, 215I, 216D, 242H
CDD
cd09087 (Ape1-like_AP-endo)

11I

active site
7N, 9N, 10G, 11I, 12R, 13A, 17K, 35E, 37K, 42Q, 61G, 62Y, 105Y, 108N, 144D, 146N, 156N, 158K, 160N, 163N, 164A, 199W, 201S, 202Y, 203R, 209N, 211A, 213W, 215I, 216D, 242H
CDD
cd09087 (Ape1-like_AP-endo)

12R

active site
7N, 9N, 10G, 11I, 12R, 13A, 17K, 35E, 37K, 42Q, 61G, 62Y, 105Y, 108N, 144D, 146N, 156N, 158K, 160N, 163N, 164A, 199W, 201S, 202Y, 203R, 209N, 211A, 213W, 215I, 216D, 242H
CDD
cd09087 (Ape1-like_AP-endo)

13A

active site
7N, 9N, 10G, 11I, 12R, 13A, 17K, 35E, 37K, 42Q, 61G, 62Y, 105Y, 108N, 144D, 146N, 156N, 158K, 160N, 163N, 164A, 199W, 201S, 202Y, 203R, 209N, 211A, 213W, 215I, 216D, 242H
CDD
cd09087 (Ape1-like_AP-endo)

17K

active site
7N, 9N, 10G, 11I, 12R, 13A, 17K, 35E, 37K, 42Q, 61G, 62Y, 105Y, 108N, 144D, 146N, 156N, 158K, 160N, 163N, 164A, 199W, 201S, 202Y, 203R, 209N, 211A, 213W, 215I, 216D, 242H
CDD
cd09087 (Ape1-like_AP-endo)

35E

active site
7N, 9N, 10G, 11I, 12R, 13A, 17K, 35E, 37K, 42Q, 61G, 62Y, 105Y, 108N, 144D, 146N, 156N, 158K, 160N, 163N, 164A, 199W, 201S, 202Y, 203R, 209N, 211A, 213W, 215I, 216D, 242H
CDD
cd09087 (Ape1-like_AP-endo)

37K

active site
7N, 9N, 10G, 11I, 12R, 13A, 17K, 35E, 37K, 42Q, 61G, 62Y, 105Y, 108N, 144D, 146N, 156N, 158K, 160N, 163N, 164A, 199W, 201S, 202Y, 203R, 209N, 211A, 213W, 215I, 216D, 242H
CDD
cd09087 (Ape1-like_AP-endo)

42Q

active site
7N, 9N, 10G, 11I, 12R, 13A, 17K, 35E, 37K, 42Q, 61G, 62Y, 105Y, 108N, 144D, 146N, 156N, 158K, 160N, 163N, 164A, 199W, 201S, 202Y, 203R, 209N, 211A, 213W, 215I, 216D, 242H
CDD
cd09087 (Ape1-like_AP-endo)

61G

active site
7N, 9N, 10G, 11I, 12R, 13A, 17K, 35E, 37K, 42Q, 61G, 62Y, 105Y, 108N, 144D, 146N, 156N, 158K, 160N, 163N, 164A, 199W, 201S, 202Y, 203R, 209N, 211A, 213W, 215I, 216D, 242H
CDD
cd09087 (Ape1-like_AP-endo)

62Y

active site
7N, 9N, 10G, 11I, 12R, 13A, 17K, 35E, 37K, 42Q, 61G, 62Y, 105Y, 108N, 144D, 146N, 156N, 158K, 160N, 163N, 164A, 199W, 201S, 202Y, 203R, 209N, 211A, 213W, 215I, 216D, 242H
CDD
cd09087 (Ape1-like_AP-endo)

105Y

active site
7N, 9N, 10G, 11I, 12R, 13A, 17K, 35E, 37K, 42Q, 61G, 62Y, 105Y, 108N, 144D, 146N, 156N, 158K, 160N, 163N, 164A, 199W, 201S, 202Y, 203R, 209N, 211A, 213W, 215I, 216D, 242H
CDD
cd09087 (Ape1-like_AP-endo)

108N

active site
7N, 9N, 10G, 11I, 12R, 13A, 17K, 35E, 37K, 42Q, 61G, 62Y, 105Y, 108N, 144D, 146N, 156N, 158K, 160N, 163N, 164A, 199W, 201S, 202Y, 203R, 209N, 211A, 213W, 215I, 216D, 242H
CDD
cd09087 (Ape1-like_AP-endo)

144D

active site
7N, 9N, 10G, 11I, 12R, 13A, 17K, 35E, 37K, 42Q, 61G, 62Y, 105Y, 108N, 144D, 146N, 156N, 158K, 160N, 163N, 164A, 199W, 201S, 202Y, 203R, 209N, 211A, 213W, 215I, 216D, 242H
CDD
cd09087 (Ape1-like_AP-endo)

146N

active site
7N, 9N, 10G, 11I, 12R, 13A, 17K, 35E, 37K, 42Q, 61G, 62Y, 105Y, 108N, 144D, 146N, 156N, 158K, 160N, 163N, 164A, 199W, 201S, 202Y, 203R, 209N, 211A, 213W, 215I, 216D, 242H
CDD
cd09087 (Ape1-like_AP-endo)

156N

active site
7N, 9N, 10G, 11I, 12R, 13A, 17K, 35E, 37K, 42Q, 61G, 62Y, 105Y, 108N, 144D, 146N, 156N, 158K, 160N, 163N, 164A, 199W, 201S, 202Y, 203R, 209N, 211A, 213W, 215I, 216D, 242H
CDD
cd09087 (Ape1-like_AP-endo)

158K

active site
7N, 9N, 10G, 11I, 12R, 13A, 17K, 35E, 37K, 42Q, 61G, 62Y, 105Y, 108N, 144D, 146N, 156N, 158K, 160N, 163N, 164A, 199W, 201S, 202Y, 203R, 209N, 211A, 213W, 215I, 216D, 242H
CDD
cd09087 (Ape1-like_AP-endo)

160N

active site
7N, 9N, 10G, 11I, 12R, 13A, 17K, 35E, 37K, 42Q, 61G, 62Y, 105Y, 108N, 144D, 146N, 156N, 158K, 160N, 163N, 164A, 199W, 201S, 202Y, 203R, 209N, 211A, 213W, 215I, 216D, 242H
CDD
cd09087 (Ape1-like_AP-endo)

163N

active site
7N, 9N, 10G, 11I, 12R, 13A, 17K, 35E, 37K, 42Q, 61G, 62Y, 105Y, 108N, 144D, 146N, 156N, 158K, 160N, 163N, 164A, 199W, 201S, 202Y, 203R, 209N, 211A, 213W, 215I, 216D, 242H
CDD
cd09087 (Ape1-like_AP-endo)

164A

active site
7N, 9N, 10G, 11I, 12R, 13A, 17K, 35E, 37K, 42Q, 61G, 62Y, 105Y, 108N, 144D, 146N, 156N, 158K, 160N, 163N, 164A, 199W, 201S, 202Y, 203R, 209N, 211A, 213W, 215I, 216D, 242H
CDD
cd09087 (Ape1-like_AP-endo)

199W

active site
7N, 9N, 10G, 11I, 12R, 13A, 17K, 35E, 37K, 42Q, 61G, 62Y, 105Y, 108N, 144D, 146N, 156N, 158K, 160N, 163N, 164A, 199W, 201S, 202Y, 203R, 209N, 211A, 213W, 215I, 216D, 242H
CDD
cd09087 (Ape1-like_AP-endo)

201S

active site
7N, 9N, 10G, 11I, 12R, 13A, 17K, 35E, 37K, 42Q, 61G, 62Y, 105Y, 108N, 144D, 146N, 156N, 158K, 160N, 163N, 164A, 199W, 201S, 202Y, 203R, 209N, 211A, 213W, 215I, 216D, 242H
CDD
cd09087 (Ape1-like_AP-endo)

202Y

active site
7N, 9N, 10G, 11I, 12R, 13A, 17K, 35E, 37K, 42Q, 61G, 62Y, 105Y, 108N, 144D, 146N, 156N, 158K, 160N, 163N, 164A, 199W, 201S, 202Y, 203R, 209N, 211A, 213W, 215I, 216D, 242H
CDD
cd09087 (Ape1-like_AP-endo)

203R

active site
7N, 9N, 10G, 11I, 12R, 13A, 17K, 35E, 37K, 42Q, 61G, 62Y, 105Y, 108N, 144D, 146N, 156N, 158K, 160N, 163N, 164A, 199W, 201S, 202Y, 203R, 209N, 211A, 213W, 215I, 216D, 242H
CDD
cd09087 (Ape1-like_AP-endo)

209N

active site
7N, 9N, 10G, 11I, 12R, 13A, 17K, 35E, 37K, 42Q, 61G, 62Y, 105Y, 108N, 144D, 146N, 156N, 158K, 160N, 163N, 164A, 199W, 201S, 202Y, 203R, 209N, 211A, 213W, 215I, 216D, 242H
CDD
cd09087 (Ape1-like_AP-endo)

211A

active site
7N, 9N, 10G, 11I, 12R, 13A, 17K, 35E, 37K, 42Q, 61G, 62Y, 105Y, 108N, 144D, 146N, 156N, 158K, 160N, 163N, 164A, 199W, 201S, 202Y, 203R, 209N, 211A, 213W, 215I, 216D, 242H
CDD
cd09087 (Ape1-like_AP-endo)

213W

active site
7N, 9N, 10G, 11I, 12R, 13A, 17K, 35E, 37K, 42Q, 61G, 62Y, 105Y, 108N, 144D, 146N, 156N, 158K, 160N, 163N, 164A, 199W, 201S, 202Y, 203R, 209N, 211A, 213W, 215I, 216D, 242H
CDD
cd09087 (Ape1-like_AP-endo)

215I

active site
7N, 9N, 10G, 11I, 12R, 13A, 17K, 35E, 37K, 42Q, 61G, 62Y, 105Y, 108N, 144D, 146N, 156N, 158K, 160N, 163N, 164A, 199W, 201S, 202Y, 203R, 209N, 211A, 213W, 215I, 216D, 242H
CDD
cd09087 (Ape1-like_AP-endo)

216D

active site
7N, 9N, 10G, 11I, 12R, 13A, 17K, 35E, 37K, 42Q, 61G, 62Y, 105Y, 108N, 144D, 146N, 156N, 158K, 160N, 163N, 164A, 199W, 201S, 202Y, 203R, 209N, 211A, 213W, 215I, 216D, 242H
CDD
cd09087 (Ape1-like_AP-endo)

242H

active site
7N, 9N, 10G, 11I, 12R, 13A, 17K, 35E, 37K, 42Q, 61G, 62Y, 105Y, 108N, 144D, 146N, 156N, 158K, 160N, 163N, 164A, 199W, 201S, 202Y, 203R, 209N, 211A, 213W, 215I, 216D, 242H
CDD
cd09087 (Ape1-like_AP-endo)
metal binding site...

9N

metal binding site A
9N, 35E, 241D
CDD
cd09087 (Ape1-like_AP-endo)

35E

metal binding site A
9N, 35E, 241D
CDD
cd09087 (Ape1-like_AP-endo)

241D

metal binding site A
9N, 35E, 241D
CDD
cd09087 (Ape1-like_AP-endo)
AP binding site cd...

105Y

AP binding site
105Y, 108N, 144D, 146N, 164A, 199W, 213W, 215I, 242H
CDD
cd09087 (Ape1-like_AP-endo)

108N

AP binding site
105Y, 108N, 144D, 146N, 164A, 199W, 213W, 215I, 242H
CDD
cd09087 (Ape1-like_AP-endo)

144D

AP binding site
105Y, 108N, 144D, 146N, 164A, 199W, 213W, 215I, 242H
CDD
cd09087 (Ape1-like_AP-endo)

146N

AP binding site
105Y, 108N, 144D, 146N, 164A, 199W, 213W, 215I, 242H
CDD
cd09087 (Ape1-like_AP-endo)

164A

AP binding site
105Y, 108N, 144D, 146N, 164A, 199W, 213W, 215I, 242H
CDD
cd09087 (Ape1-like_AP-endo)

199W

AP binding site
105Y, 108N, 144D, 146N, 164A, 199W, 213W, 215I, 242H
CDD
cd09087 (Ape1-like_AP-endo)

213W

AP binding site
105Y, 108N, 144D, 146N, 164A, 199W, 213W, 215I, 242H
CDD
cd09087 (Ape1-like_AP-endo)

215I

AP binding site
105Y, 108N, 144D, 146N, 164A, 199W, 213W, 215I, 242H
CDD
cd09087 (Ape1-like_AP-endo)

242H

AP binding site
105Y, 108N, 144D, 146N, 164A, 199W, 213W, 215I, 242H
CDD
cd09087 (Ape1-like_AP-endo)
metal binding site...

144D

metal binding site B
144D, 146N, 242H
CDD
cd09087 (Ape1-like_AP-endo)

146N

metal binding site B
144D, 146N, 242H
CDD
cd09087 (Ape1-like_AP-endo)

242H

metal binding site B
144D, 146N, 242H
CDD
cd09087 (Ape1-like_AP-endo)

GO term prediction

Biological Process

GO:0006281 DNA repair

Molecular Function

GO:0003677 DNA binding
GO:0004518 nuclease activity
GO:0004519 endonuclease activity

Cellular Component

GO:0005622 intracellular