23726_FusoPortal_Gene_701

Protein

23726_FusoPortal_Gene_701

Length

485 amino acids

Protein family membership

Glutamate mutase epsilon subunit (IPR006396)

Homologous superfamilies

Homologous superfamily
1 - 482
Cobalamin (vitamin B12)-dependent enzyme, catalytic (IPR016176)
Homologous superfamily
418 - 482
Glutamate mutase E subunit, C-terminal domain superfamily (IPR014714)

1 50 100 150 200 250 300 350 400 450 485

Domains and repeats

None predicted.

Detailed signature matches

IPR016176

Cobalamin (vitamin B12)-dependent enzyme, catalytic
1. G3DSA:3.20.20...
  
  1 - 417
  
  GENE3D
  G3DSA:3.20.20.240 (G3DSA:3.20.20.240)
2. SSF51703 (Cobalamin...)
  
  1 - 482
  
  SUPERFAMILY
  SSF51703 (Cobalamin (vitamin B12)-dependent enzymes)
IPR014714

Glutamate mutase E subunit, C-terminal domain superfamily
1. G3DSA:3.90.97...
  
  418 - 482
  
  GENE3D
  G3DSA:3.90.970.10 (G3DSA:3.90.970.10)
IPR006396

Glutamate mutase epsilon subunit
1. MF_01923 (Me_Asp_mu...)
  
  2 - 482
  
  HAMAP
  MF_01923 (Me_Asp_mutase_E)
2. TIGR01503
  
  3 - 482
  
  TIGRFAMs
  TIGR01503 (TIGR01503)
3. PIRSF001495 (Met_as...)
  
  1 - 483
  
  PIRSF
  PIRSF001495 (Met_asp_mut_epsi)
4. cd00245 (Glm_e)
  
  46 - 473
  
  CDD
  cd00245 (Glm_e)
5. PF06368 (Met_asp_mut_E)
  
  42 - 481
  
  Pfam
  PF06368 (Met_asp_mut_E)

Residue annotation

substrate binding ...

66H

substrate binding site
66H, 94I, 100R, 149K, 150H, 171D, 177H, 181F, 216F
CDD
cd00245 (Glm_e)

94I

substrate binding site
66H, 94I, 100R, 149K, 150H, 171D, 177H, 181F, 216F
CDD
cd00245 (Glm_e)

100R

substrate binding site
66H, 94I, 100R, 149K, 150H, 171D, 177H, 181F, 216F
CDD
cd00245 (Glm_e)

149K

substrate binding site
66H, 94I, 100R, 149K, 150H, 171D, 177H, 181F, 216F
CDD
cd00245 (Glm_e)

150H

substrate binding site
66H, 94I, 100R, 149K, 150H, 171D, 177H, 181F, 216F
CDD
cd00245 (Glm_e)

171D

substrate binding site
66H, 94I, 100R, 149K, 150H, 171D, 177H, 181F, 216F
CDD
cd00245 (Glm_e)

177H

substrate binding site
66H, 94I, 100R, 149K, 150H, 171D, 177H, 181F, 216F
CDD
cd00245 (Glm_e)

181F

substrate binding site
66H, 94I, 100R, 149K, 150H, 171D, 177H, 181F, 216F
CDD
cd00245 (Glm_e)

216F

substrate binding site
66H, 94I, 100R, 149K, 150H, 171D, 177H, 181F, 216F
CDD
cd00245 (Glm_e)
B12 cofactor bindi...

94I

B12 cofactor binding site
94I, 180P, 220T, 294I, 295G, 296G, 297F, 329D, 330E, 333K, 334N, 471F
CDD
cd00245 (Glm_e)

180P

B12 cofactor binding site
94I, 180P, 220T, 294I, 295G, 296G, 297F, 329D, 330E, 333K, 334N, 471F
CDD
cd00245 (Glm_e)

220T

B12 cofactor binding site
94I, 180P, 220T, 294I, 295G, 296G, 297F, 329D, 330E, 333K, 334N, 471F
CDD
cd00245 (Glm_e)

294I

B12 cofactor binding site
94I, 180P, 220T, 294I, 295G, 296G, 297F, 329D, 330E, 333K, 334N, 471F
CDD
cd00245 (Glm_e)

295G

B12 cofactor binding site
94I, 180P, 220T, 294I, 295G, 296G, 297F, 329D, 330E, 333K, 334N, 471F
CDD
cd00245 (Glm_e)

296G

B12 cofactor binding site
94I, 180P, 220T, 294I, 295G, 296G, 297F, 329D, 330E, 333K, 334N, 471F
CDD
cd00245 (Glm_e)

297F

B12 cofactor binding site
94I, 180P, 220T, 294I, 295G, 296G, 297F, 329D, 330E, 333K, 334N, 471F
CDD
cd00245 (Glm_e)

329D

B12 cofactor binding site
94I, 180P, 220T, 294I, 295G, 296G, 297F, 329D, 330E, 333K, 334N, 471F
CDD
cd00245 (Glm_e)

330E

B12 cofactor binding site
94I, 180P, 220T, 294I, 295G, 296G, 297F, 329D, 330E, 333K, 334N, 471F
CDD
cd00245 (Glm_e)

333K

B12 cofactor binding site
94I, 180P, 220T, 294I, 295G, 296G, 297F, 329D, 330E, 333K, 334N, 471F
CDD
cd00245 (Glm_e)

334N

B12 cofactor binding site
94I, 180P, 220T, 294I, 295G, 296G, 297F, 329D, 330E, 333K, 334N, 471F
CDD
cd00245 (Glm_e)

471F

B12 cofactor binding site
94I, 180P, 220T, 294I, 295G, 296G, 297F, 329D, 330E, 333K, 334N, 471F
CDD
cd00245 (Glm_e)
heterodimer (sigma...

97S

heterodimer (sigma-epsilon) interface
97S, 98H, 101E, 122L, 123N, 180P, 181F, 183K, 331Y, 332A, 467I
CDD
cd00245 (Glm_e)

98H

heterodimer (sigma-epsilon) interface
97S, 98H, 101E, 122L, 123N, 180P, 181F, 183K, 331Y, 332A, 467I
CDD
cd00245 (Glm_e)

101E

heterodimer (sigma-epsilon) interface
97S, 98H, 101E, 122L, 123N, 180P, 181F, 183K, 331Y, 332A, 467I
CDD
cd00245 (Glm_e)

122L

heterodimer (sigma-epsilon) interface
97S, 98H, 101E, 122L, 123N, 180P, 181F, 183K, 331Y, 332A, 467I
CDD
cd00245 (Glm_e)

123N

heterodimer (sigma-epsilon) interface
97S, 98H, 101E, 122L, 123N, 180P, 181F, 183K, 331Y, 332A, 467I
CDD
cd00245 (Glm_e)

180P

heterodimer (sigma-epsilon) interface
97S, 98H, 101E, 122L, 123N, 180P, 181F, 183K, 331Y, 332A, 467I
CDD
cd00245 (Glm_e)

181F

heterodimer (sigma-epsilon) interface
97S, 98H, 101E, 122L, 123N, 180P, 181F, 183K, 331Y, 332A, 467I
CDD
cd00245 (Glm_e)

183K

heterodimer (sigma-epsilon) interface
97S, 98H, 101E, 122L, 123N, 180P, 181F, 183K, 331Y, 332A, 467I
CDD
cd00245 (Glm_e)

331Y

heterodimer (sigma-epsilon) interface
97S, 98H, 101E, 122L, 123N, 180P, 181F, 183K, 331Y, 332A, 467I
CDD
cd00245 (Glm_e)

332A

heterodimer (sigma-epsilon) interface
97S, 98H, 101E, 122L, 123N, 180P, 181F, 183K, 331Y, 332A, 467I
CDD
cd00245 (Glm_e)

467I

heterodimer (sigma-epsilon) interface
97S, 98H, 101E, 122L, 123N, 180P, 181F, 183K, 331Y, 332A, 467I
CDD
cd00245 (Glm_e)
homodimer (epsilon...

256G

homodimer (epsilon-epsilon) interface
256G, 258I, 300E, 302L, 303K, 309S, 310Y, 313T, 342N, 345L, 346L, 349T, 352D, 425E, 473M
CDD
cd00245 (Glm_e)

258I

homodimer (epsilon-epsilon) interface
256G, 258I, 300E, 302L, 303K, 309S, 310Y, 313T, 342N, 345L, 346L, 349T, 352D, 425E, 473M
CDD
cd00245 (Glm_e)

300E

homodimer (epsilon-epsilon) interface
256G, 258I, 300E, 302L, 303K, 309S, 310Y, 313T, 342N, 345L, 346L, 349T, 352D, 425E, 473M
CDD
cd00245 (Glm_e)

302L

homodimer (epsilon-epsilon) interface
256G, 258I, 300E, 302L, 303K, 309S, 310Y, 313T, 342N, 345L, 346L, 349T, 352D, 425E, 473M
CDD
cd00245 (Glm_e)

303K

homodimer (epsilon-epsilon) interface
256G, 258I, 300E, 302L, 303K, 309S, 310Y, 313T, 342N, 345L, 346L, 349T, 352D, 425E, 473M
CDD
cd00245 (Glm_e)

309S

homodimer (epsilon-epsilon) interface
256G, 258I, 300E, 302L, 303K, 309S, 310Y, 313T, 342N, 345L, 346L, 349T, 352D, 425E, 473M
CDD
cd00245 (Glm_e)

310Y

homodimer (epsilon-epsilon) interface
256G, 258I, 300E, 302L, 303K, 309S, 310Y, 313T, 342N, 345L, 346L, 349T, 352D, 425E, 473M
CDD
cd00245 (Glm_e)

313T

homodimer (epsilon-epsilon) interface
256G, 258I, 300E, 302L, 303K, 309S, 310Y, 313T, 342N, 345L, 346L, 349T, 352D, 425E, 473M
CDD
cd00245 (Glm_e)

342N

homodimer (epsilon-epsilon) interface
256G, 258I, 300E, 302L, 303K, 309S, 310Y, 313T, 342N, 345L, 346L, 349T, 352D, 425E, 473M
CDD
cd00245 (Glm_e)

345L

homodimer (epsilon-epsilon) interface
256G, 258I, 300E, 302L, 303K, 309S, 310Y, 313T, 342N, 345L, 346L, 349T, 352D, 425E, 473M
CDD
cd00245 (Glm_e)

346L

homodimer (epsilon-epsilon) interface
256G, 258I, 300E, 302L, 303K, 309S, 310Y, 313T, 342N, 345L, 346L, 349T, 352D, 425E, 473M
CDD
cd00245 (Glm_e)

349T

homodimer (epsilon-epsilon) interface
256G, 258I, 300E, 302L, 303K, 309S, 310Y, 313T, 342N, 345L, 346L, 349T, 352D, 425E, 473M
CDD
cd00245 (Glm_e)

352D

homodimer (epsilon-epsilon) interface
256G, 258I, 300E, 302L, 303K, 309S, 310Y, 313T, 342N, 345L, 346L, 349T, 352D, 425E, 473M
CDD
cd00245 (Glm_e)

425E

homodimer (epsilon-epsilon) interface
256G, 258I, 300E, 302L, 303K, 309S, 310Y, 313T, 342N, 345L, 346L, 349T, 352D, 425E, 473M
CDD
cd00245 (Glm_e)

473M

homodimer (epsilon-epsilon) interface
256G, 258I, 300E, 302L, 303K, 309S, 310Y, 313T, 342N, 345L, 346L, 349T, 352D, 425E, 473M
CDD
cd00245 (Glm_e)

GO term prediction

Biological Process

GO:0008152 metabolic process
GO:0019670 anaerobic glutamate catabolic process

Molecular Function

GO:0003824 catalytic activity
GO:0016866 intramolecular transferase activity
GO:0031419 cobalamin binding
GO:0050097 methylaspartate mutase activity

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features

23726_FusoPortal_Gene_701

Protein family membership

Homologous superfamilies

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component