23726_FusoPortal_Gene_712

Protein

23726_FusoPortal_Gene_712

Length

257 amino acids

Protein family membership

Short-chain dehydrogenase/reductase SDR (IPR002347)

Homologous superfamilies

Homologous superfamily
3 - 252
NAD(P)-binding domain superfamily (IPR036291)

1 50 100 150 200 257

Domains and repeats

None predicted.

Detailed signature matches

IPR036291

NAD(P)-binding domain superfamily
1. SSF51735 (NAD(P)-bi...)
  
  3 - 252
  
  SUPERFAMILY
  SSF51735 (NAD(P)-binding Rossmann-fold domains)
IPR002347

Short-chain dehydrogenase/reductase SDR
1. PR00080 (SDRFAMILY)
  
  147 - 166
  
  PRINTS
  PR00080 (SDRFAMILY)
  
  74 - 85
  
  PRINTS
  PR00080 (SDRFAMILY)
  
  127 - 135
  
  PRINTS
  PR00080 (SDRFAMILY)
2. PR00081 (GDHRDH)
  
  74 - 85
  
  PRINTS
  PR00081 (GDHRDH)
  
  3 - 20
  
  PRINTS
  PR00081 (GDHRDH)
  
  121 - 137
  
  PRINTS
  PR00081 (GDHRDH)
  
  147 - 166
  
  PRINTS
  PR00081 (GDHRDH)
  
  170 - 187
  
  PRINTS
  PR00081 (GDHRDH)
3. PF00106 (adh_short)
  
  3 - 190
  
  Pfam
  PF00106 (adh_short)

no IPR

Unintegrated signatures

Coil

28 - 55

COILS
Coil (Coil)
G3DSA:3.40.50...

4 - 243

GENE3D
G3DSA:3.40.50.720 (G3DSA:3.40.50.720)
PIRSF000126 (11-bet...)

2 - 252

PIRSF
PIRSF000126 (11-beta-HSD1)
PTHR43086 (FAMILY N...)

4 - 254

PANTHER
PTHR43086 (FAMILY NOT NAMED)
PTHR43086:SF2 (HYDR...)

4 - 254

PANTHER
PTHR43086:SF2 (HYDROXYSTEROID DEHYDROGENASE-LIKE PROTEIN 1)
cd05233 (SDR_c)

4 - 222

CDD
cd05233 (SDR_c)

Residue annotation

NAD(P) binding sit...

8G

NAD(P) binding site
8G, 10S, 11S, 12G, 13I, 32A, 33R, 34S, 59Y, 60D, 61L, 82C, 83A, 84G, 105V, 132I, 133C, 134S, 147Y, 151K, 179P, 180G, 181P, 182T, 184S, 185N
CDD
cd05233 (SDR_c)

10S

NAD(P) binding site
8G, 10S, 11S, 12G, 13I, 32A, 33R, 34S, 59Y, 60D, 61L, 82C, 83A, 84G, 105V, 132I, 133C, 134S, 147Y, 151K, 179P, 180G, 181P, 182T, 184S, 185N
CDD
cd05233 (SDR_c)

11S

NAD(P) binding site
8G, 10S, 11S, 12G, 13I, 32A, 33R, 34S, 59Y, 60D, 61L, 82C, 83A, 84G, 105V, 132I, 133C, 134S, 147Y, 151K, 179P, 180G, 181P, 182T, 184S, 185N
CDD
cd05233 (SDR_c)

12G

NAD(P) binding site
8G, 10S, 11S, 12G, 13I, 32A, 33R, 34S, 59Y, 60D, 61L, 82C, 83A, 84G, 105V, 132I, 133C, 134S, 147Y, 151K, 179P, 180G, 181P, 182T, 184S, 185N
CDD
cd05233 (SDR_c)

13I

NAD(P) binding site
8G, 10S, 11S, 12G, 13I, 32A, 33R, 34S, 59Y, 60D, 61L, 82C, 83A, 84G, 105V, 132I, 133C, 134S, 147Y, 151K, 179P, 180G, 181P, 182T, 184S, 185N
CDD
cd05233 (SDR_c)

32A

NAD(P) binding site
8G, 10S, 11S, 12G, 13I, 32A, 33R, 34S, 59Y, 60D, 61L, 82C, 83A, 84G, 105V, 132I, 133C, 134S, 147Y, 151K, 179P, 180G, 181P, 182T, 184S, 185N
CDD
cd05233 (SDR_c)

33R

NAD(P) binding site
8G, 10S, 11S, 12G, 13I, 32A, 33R, 34S, 59Y, 60D, 61L, 82C, 83A, 84G, 105V, 132I, 133C, 134S, 147Y, 151K, 179P, 180G, 181P, 182T, 184S, 185N
CDD
cd05233 (SDR_c)

34S

NAD(P) binding site
8G, 10S, 11S, 12G, 13I, 32A, 33R, 34S, 59Y, 60D, 61L, 82C, 83A, 84G, 105V, 132I, 133C, 134S, 147Y, 151K, 179P, 180G, 181P, 182T, 184S, 185N
CDD
cd05233 (SDR_c)

59Y

NAD(P) binding site
8G, 10S, 11S, 12G, 13I, 32A, 33R, 34S, 59Y, 60D, 61L, 82C, 83A, 84G, 105V, 132I, 133C, 134S, 147Y, 151K, 179P, 180G, 181P, 182T, 184S, 185N
CDD
cd05233 (SDR_c)

60D

NAD(P) binding site
8G, 10S, 11S, 12G, 13I, 32A, 33R, 34S, 59Y, 60D, 61L, 82C, 83A, 84G, 105V, 132I, 133C, 134S, 147Y, 151K, 179P, 180G, 181P, 182T, 184S, 185N
CDD
cd05233 (SDR_c)

61L

NAD(P) binding site
8G, 10S, 11S, 12G, 13I, 32A, 33R, 34S, 59Y, 60D, 61L, 82C, 83A, 84G, 105V, 132I, 133C, 134S, 147Y, 151K, 179P, 180G, 181P, 182T, 184S, 185N
CDD
cd05233 (SDR_c)

82C

NAD(P) binding site
8G, 10S, 11S, 12G, 13I, 32A, 33R, 34S, 59Y, 60D, 61L, 82C, 83A, 84G, 105V, 132I, 133C, 134S, 147Y, 151K, 179P, 180G, 181P, 182T, 184S, 185N
CDD
cd05233 (SDR_c)

83A

NAD(P) binding site
8G, 10S, 11S, 12G, 13I, 32A, 33R, 34S, 59Y, 60D, 61L, 82C, 83A, 84G, 105V, 132I, 133C, 134S, 147Y, 151K, 179P, 180G, 181P, 182T, 184S, 185N
CDD
cd05233 (SDR_c)

84G

NAD(P) binding site
8G, 10S, 11S, 12G, 13I, 32A, 33R, 34S, 59Y, 60D, 61L, 82C, 83A, 84G, 105V, 132I, 133C, 134S, 147Y, 151K, 179P, 180G, 181P, 182T, 184S, 185N
CDD
cd05233 (SDR_c)

105V

NAD(P) binding site
8G, 10S, 11S, 12G, 13I, 32A, 33R, 34S, 59Y, 60D, 61L, 82C, 83A, 84G, 105V, 132I, 133C, 134S, 147Y, 151K, 179P, 180G, 181P, 182T, 184S, 185N
CDD
cd05233 (SDR_c)

132I

NAD(P) binding site
8G, 10S, 11S, 12G, 13I, 32A, 33R, 34S, 59Y, 60D, 61L, 82C, 83A, 84G, 105V, 132I, 133C, 134S, 147Y, 151K, 179P, 180G, 181P, 182T, 184S, 185N
CDD
cd05233 (SDR_c)

133C

NAD(P) binding site
8G, 10S, 11S, 12G, 13I, 32A, 33R, 34S, 59Y, 60D, 61L, 82C, 83A, 84G, 105V, 132I, 133C, 134S, 147Y, 151K, 179P, 180G, 181P, 182T, 184S, 185N
CDD
cd05233 (SDR_c)

134S

NAD(P) binding site
8G, 10S, 11S, 12G, 13I, 32A, 33R, 34S, 59Y, 60D, 61L, 82C, 83A, 84G, 105V, 132I, 133C, 134S, 147Y, 151K, 179P, 180G, 181P, 182T, 184S, 185N
CDD
cd05233 (SDR_c)

147Y

NAD(P) binding site
8G, 10S, 11S, 12G, 13I, 32A, 33R, 34S, 59Y, 60D, 61L, 82C, 83A, 84G, 105V, 132I, 133C, 134S, 147Y, 151K, 179P, 180G, 181P, 182T, 184S, 185N
CDD
cd05233 (SDR_c)

151K

NAD(P) binding site
8G, 10S, 11S, 12G, 13I, 32A, 33R, 34S, 59Y, 60D, 61L, 82C, 83A, 84G, 105V, 132I, 133C, 134S, 147Y, 151K, 179P, 180G, 181P, 182T, 184S, 185N
CDD
cd05233 (SDR_c)

179P

NAD(P) binding site
8G, 10S, 11S, 12G, 13I, 32A, 33R, 34S, 59Y, 60D, 61L, 82C, 83A, 84G, 105V, 132I, 133C, 134S, 147Y, 151K, 179P, 180G, 181P, 182T, 184S, 185N
CDD
cd05233 (SDR_c)

180G

NAD(P) binding site
8G, 10S, 11S, 12G, 13I, 32A, 33R, 34S, 59Y, 60D, 61L, 82C, 83A, 84G, 105V, 132I, 133C, 134S, 147Y, 151K, 179P, 180G, 181P, 182T, 184S, 185N
CDD
cd05233 (SDR_c)

181P

NAD(P) binding site
8G, 10S, 11S, 12G, 13I, 32A, 33R, 34S, 59Y, 60D, 61L, 82C, 83A, 84G, 105V, 132I, 133C, 134S, 147Y, 151K, 179P, 180G, 181P, 182T, 184S, 185N
CDD
cd05233 (SDR_c)

182T

NAD(P) binding site
8G, 10S, 11S, 12G, 13I, 32A, 33R, 34S, 59Y, 60D, 61L, 82C, 83A, 84G, 105V, 132I, 133C, 134S, 147Y, 151K, 179P, 180G, 181P, 182T, 184S, 185N
CDD
cd05233 (SDR_c)

184S

NAD(P) binding site
8G, 10S, 11S, 12G, 13I, 32A, 33R, 34S, 59Y, 60D, 61L, 82C, 83A, 84G, 105V, 132I, 133C, 134S, 147Y, 151K, 179P, 180G, 181P, 182T, 184S, 185N
CDD
cd05233 (SDR_c)

185N

NAD(P) binding site
8G, 10S, 11S, 12G, 13I, 32A, 33R, 34S, 59Y, 60D, 61L, 82C, 83A, 84G, 105V, 132I, 133C, 134S, 147Y, 151K, 179P, 180G, 181P, 182T, 184S, 185N
CDD
cd05233 (SDR_c)
active site cd05233

106N

active site
106N, 134S, 147Y, 151K
CDD
cd05233 (SDR_c)

134S

active site
106N, 134S, 147Y, 151K
CDD
cd05233 (SDR_c)

147Y

active site
106N, 134S, 147Y, 151K
CDD
cd05233 (SDR_c)

151K

active site
106N, 134S, 147Y, 151K
CDD
cd05233 (SDR_c)

GO term prediction

Biological Process

None predicted.

Molecular Function

None predicted.

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features

23726_FusoPortal_Gene_712

Protein family membership

Homologous superfamilies

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component