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Entry type
Status
Per-residue features
Colour by
23726_FusoPortal_Gene_894
Length
1,449 amino acids
Protein family membership
Homologous superfamilies
-
Homologous superfamily409 - 559
- Ribonuclease H superfamily (IPR036397)
-
Homologous superfamily421 - 886
- Ribonuclease H-like superfamily (IPR012337)
1
200
400
600
800
1000
1200
1449
Domains and repeats
-
Domain332 - 696
- PHP domain (IPR004013)
835 - 1,262- Bacterial DNA polymerase III, alpha subunit (IPR011708)
1,361 - 1,443- DNA polymerase, helix-hairpin-helix motif (IPR029460)
-
Domain417 - 635
- Exonuclease, RNase T/DNA polymerase III (IPR013520)
1
200
400
600
800
1000
1200
1449
Detailed signature matches
-
-
409 - 559
-

Unintegrated signatures
-
1,330 - 1,443
-
563 - 584
-
178 - 326
-
585 - 804
-
327 - 402
-
PTHR23044 (3'-5' EX...)39 - 1,296
-
PTHR23044:SF26 (SUB...)39 - 1,296
-
cd04484 (polC_OBF)236 - 315
-
cd06127 (DEDDh)423 - 579
-
cd07435 (PHP_PolIII...)330 - 818
Residue annotation
-
generic binding su...238I288F290K292S313N
-
generic binding su...243Igeneric binding surface I
243I, 244F, 245S, 259T, 260I, 261R, 262V, 264D, 270T, 271S, 272K, 274F, 287M, 294K, 295L, 296Q, 304E, 305K, 306T
CDD
cd04484 (polC_OBF)244Fgeneric binding surface I
243I, 244F, 245S, 259T, 260I, 261R, 262V, 264D, 270T, 271S, 272K, 274F, 287M, 294K, 295L, 296Q, 304E, 305K, 306T
CDD
cd04484 (polC_OBF)245Sgeneric binding surface I
243I, 244F, 245S, 259T, 260I, 261R, 262V, 264D, 270T, 271S, 272K, 274F, 287M, 294K, 295L, 296Q, 304E, 305K, 306T
CDD
cd04484 (polC_OBF)259Tgeneric binding surface I
243I, 244F, 245S, 259T, 260I, 261R, 262V, 264D, 270T, 271S, 272K, 274F, 287M, 294K, 295L, 296Q, 304E, 305K, 306T
CDD
cd04484 (polC_OBF)260Igeneric binding surface I
243I, 244F, 245S, 259T, 260I, 261R, 262V, 264D, 270T, 271S, 272K, 274F, 287M, 294K, 295L, 296Q, 304E, 305K, 306T
CDD
cd04484 (polC_OBF)261Rgeneric binding surface I
243I, 244F, 245S, 259T, 260I, 261R, 262V, 264D, 270T, 271S, 272K, 274F, 287M, 294K, 295L, 296Q, 304E, 305K, 306T
CDD
cd04484 (polC_OBF)262Vgeneric binding surface I
243I, 244F, 245S, 259T, 260I, 261R, 262V, 264D, 270T, 271S, 272K, 274F, 287M, 294K, 295L, 296Q, 304E, 305K, 306T
CDD
cd04484 (polC_OBF)264Dgeneric binding surface I
243I, 244F, 245S, 259T, 260I, 261R, 262V, 264D, 270T, 271S, 272K, 274F, 287M, 294K, 295L, 296Q, 304E, 305K, 306T
CDD
cd04484 (polC_OBF)270Tgeneric binding surface I
243I, 244F, 245S, 259T, 260I, 261R, 262V, 264D, 270T, 271S, 272K, 274F, 287M, 294K, 295L, 296Q, 304E, 305K, 306T
CDD
cd04484 (polC_OBF)271Sgeneric binding surface I
243I, 244F, 245S, 259T, 260I, 261R, 262V, 264D, 270T, 271S, 272K, 274F, 287M, 294K, 295L, 296Q, 304E, 305K, 306T
CDD
cd04484 (polC_OBF)272Kgeneric binding surface I
243I, 244F, 245S, 259T, 260I, 261R, 262V, 264D, 270T, 271S, 272K, 274F, 287M, 294K, 295L, 296Q, 304E, 305K, 306T
CDD
cd04484 (polC_OBF)274Fgeneric binding surface I
243I, 244F, 245S, 259T, 260I, 261R, 262V, 264D, 270T, 271S, 272K, 274F, 287M, 294K, 295L, 296Q, 304E, 305K, 306T
CDD
cd04484 (polC_OBF)287Mgeneric binding surface I
243I, 244F, 245S, 259T, 260I, 261R, 262V, 264D, 270T, 271S, 272K, 274F, 287M, 294K, 295L, 296Q, 304E, 305K, 306T
CDD
cd04484 (polC_OBF)294Kgeneric binding surface I
243I, 244F, 245S, 259T, 260I, 261R, 262V, 264D, 270T, 271S, 272K, 274F, 287M, 294K, 295L, 296Q, 304E, 305K, 306T
CDD
cd04484 (polC_OBF)295Lgeneric binding surface I
243I, 244F, 245S, 259T, 260I, 261R, 262V, 264D, 270T, 271S, 272K, 274F, 287M, 294K, 295L, 296Q, 304E, 305K, 306T
CDD
cd04484 (polC_OBF)296Qgeneric binding surface I
243I, 244F, 245S, 259T, 260I, 261R, 262V, 264D, 270T, 271S, 272K, 274F, 287M, 294K, 295L, 296Q, 304E, 305K, 306T
CDD
cd04484 (polC_OBF)304Egeneric binding surface I
243I, 244F, 245S, 259T, 260I, 261R, 262V, 264D, 270T, 271S, 272K, 274F, 287M, 294K, 295L, 296Q, 304E, 305K, 306T
CDD
cd04484 (polC_OBF)305Kgeneric binding surface I
243I, 244F, 245S, 259T, 260I, 261R, 262V, 264D, 270T, 271S, 272K, 274F, 287M, 294K, 295L, 296Q, 304E, 305K, 306T
CDD
cd04484 (polC_OBF)306Tgeneric binding surface I
243I, 244F, 245S, 259T, 260I, 261R, 262V, 264D, 270T, 271S, 272K, 274F, 287M, 294K, 295L, 296Q, 304E, 305K, 306T
CDD
cd04484 (polC_OBF) -
active site cd07435336H343V368Y398E743N745H
-
putative PHP Thumb...382K391M392K393A813E
-
catalytic site cd0...426D428E511D565H570D
-
substrate binding ...426Dsubstrate binding site
426D, 427I, 428E, 429T, 431G, 506H, 507N, 509P, 510F, 565H, 570D
CDD
cd06127 (DEDDh)427Isubstrate binding site
426D, 427I, 428E, 429T, 431G, 506H, 507N, 509P, 510F, 565H, 570D
CDD
cd06127 (DEDDh)428Esubstrate binding site
426D, 427I, 428E, 429T, 431G, 506H, 507N, 509P, 510F, 565H, 570D
CDD
cd06127 (DEDDh)429Tsubstrate binding site
426D, 427I, 428E, 429T, 431G, 506H, 507N, 509P, 510F, 565H, 570D
CDD
cd06127 (DEDDh)431Gsubstrate binding site
426D, 427I, 428E, 429T, 431G, 506H, 507N, 509P, 510F, 565H, 570D
CDD
cd06127 (DEDDh)506Hsubstrate binding site
426D, 427I, 428E, 429T, 431G, 506H, 507N, 509P, 510F, 565H, 570D
CDD
cd06127 (DEDDh)507Nsubstrate binding site
426D, 427I, 428E, 429T, 431G, 506H, 507N, 509P, 510F, 565H, 570D
CDD
cd06127 (DEDDh)509Psubstrate binding site
426D, 427I, 428E, 429T, 431G, 506H, 507N, 509P, 510F, 565H, 570D
CDD
cd06127 (DEDDh)510Fsubstrate binding site
426D, 427I, 428E, 429T, 431G, 506H, 507N, 509P, 510F, 565H, 570D
CDD
cd06127 (DEDDh)565Hsubstrate binding site
426D, 427I, 428E, 429T, 431G, 506H, 507N, 509P, 510F, 565H, 570D
CDD
cd06127 (DEDDh)570Dsubstrate binding site
426D, 427I, 428E, 429T, 431G, 506H, 507N, 509P, 510F, 565H, 570D
CDD
cd06127 (DEDDh) -
active site cd06127426Dactive site
426D, 427I, 428E, 429T, 431G, 506H, 507N, 509P, 510F, 511D, 565H, 570D
CDD
cd06127 (DEDDh)427Iactive site
426D, 427I, 428E, 429T, 431G, 506H, 507N, 509P, 510F, 511D, 565H, 570D
CDD
cd06127 (DEDDh)428Eactive site
426D, 427I, 428E, 429T, 431G, 506H, 507N, 509P, 510F, 511D, 565H, 570D
CDD
cd06127 (DEDDh)429Tactive site
426D, 427I, 428E, 429T, 431G, 506H, 507N, 509P, 510F, 511D, 565H, 570D
CDD
cd06127 (DEDDh)431Gactive site
426D, 427I, 428E, 429T, 431G, 506H, 507N, 509P, 510F, 511D, 565H, 570D
CDD
cd06127 (DEDDh)506Hactive site
426D, 427I, 428E, 429T, 431G, 506H, 507N, 509P, 510F, 511D, 565H, 570D
CDD
cd06127 (DEDDh)507Nactive site
426D, 427I, 428E, 429T, 431G, 506H, 507N, 509P, 510F, 511D, 565H, 570D
CDD
cd06127 (DEDDh)509Pactive site
426D, 427I, 428E, 429T, 431G, 506H, 507N, 509P, 510F, 511D, 565H, 570D
CDD
cd06127 (DEDDh)510Factive site
426D, 427I, 428E, 429T, 431G, 506H, 507N, 509P, 510F, 511D, 565H, 570D
CDD
cd06127 (DEDDh)511Dactive site
426D, 427I, 428E, 429T, 431G, 506H, 507N, 509P, 510F, 511D, 565H, 570D
CDD
cd06127 (DEDDh)565Hactive site
426D, 427I, 428E, 429T, 431G, 506H, 507N, 509P, 510F, 511D, 565H, 570D
CDD
cd06127 (DEDDh)570Dactive site
426D, 427I, 428E, 429T, 431G, 506H, 507N, 509P, 510F, 511D, 565H, 570D
CDD
cd06127 (DEDDh)
GO term prediction
Biological Process
GO:0006260 DNA replication
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003824 catalytic activity
GO:0003887 DNA-directed DNA polymerase activity
GO:0008408 3'-5' exonuclease activity
Cellular Component
GO:0005737 cytoplasm