25563_FusoPortal_Gene_1060

Protein

25563_FusoPortal_Gene_1060

Length

707 amino acids

Protein family membership

Polyribonucleotide nucleotidyltransferase (IPR012162)

Homologous superfamilies

Homologous superfamily
7 - 144
Ribosomal protein S5 domain 2-type fold (IPR020568)
302 - 497
Ribosomal protein S5 domain 2-type fold (IPR020568)
618 - 701
Nucleic acid-binding, OB-fold (IPR012340)
Homologous superfamily
11 - 250
PNPase/RNase PH domain superfamily (IPR027408)
326 - 553
PNPase/RNase PH domain superfamily (IPR027408)
Homologous superfamily
138 - 230
Exoribonuclease, PH domain 2 superfamily (IPR036345)
239 - 329
Polyribonucleotide nucleotidyltransferase, RNA-binding domain superfamily (IPR036456)
459 - 553
Exoribonuclease, PH domain 2 superfamily (IPR036345)
554 - 637
K Homology domain, type 1 superfamily (IPR036612)

1 100 200 300 400 500 600 707

Domains and repeats

Domain
14 - 144
Exoribonuclease, phosphorolytic domain 1 (IPR001247)
147 - 210
Exoribonuclease, phosphorolytic domain 2 (IPR015847)
244 - 329
Polyribonucleotide nucleotidyltransferase, RNA-binding domain (IPR015848)
332 - 465
Exoribonuclease, phosphorolytic domain 1 (IPR001247)
470 - 536
Exoribonuclease, phosphorolytic domain 2 (IPR015847)
564 - 607
K Homology domain, type 1 (IPR004088)
628 - 697
S1 domain (IPR003029)

1 100 200 300 400 500 600 707

Detailed signature matches

IPR020568

Ribosomal protein S5 domain 2-type fold
1. SSF54211 (Ribosomal...)
  
  302 - 497
  
  SUPERFAMILY
  SSF54211 (Ribosomal protein S5 domain 2-like)
  
  7 - 144
  
  SUPERFAMILY
  SSF54211 (Ribosomal protein S5 domain 2-like)
IPR027408

PNPase/RNase PH domain superfamily
1. G3DSA:3.30.23...
  
  11 - 250
  
  GENE3D
  G3DSA:3.30.230.70 (G3DSA:3.30.230.70)
  
  326 - 553
  
  GENE3D
  G3DSA:3.30.230.70 (G3DSA:3.30.230.70)
IPR036345

Exoribonuclease, PH domain 2 superfamily
1. SSF55666 (Ribonucle...)
  
  459 - 553
  
  SUPERFAMILY
  SSF55666 (Ribonuclease PH domain 2-like)
  
  138 - 230
  
  SUPERFAMILY
  SSF55666 (Ribonuclease PH domain 2-like)
IPR036456

Polyribonucleotide nucleotidyltransferase, RNA-binding domain superfamily
1. G3DSA:1.10.10...
  
  251 - 325
  
  GENE3D
  G3DSA:1.10.10.400 (G3DSA:1.10.10.400)
2. SSF46915 (Polynucle...)
  
  239 - 329
  
  SUPERFAMILY
  SSF46915 (Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3)
IPR036612

K Homology domain, type 1 superfamily
1. G3DSA:3.30.13...
  
  554 - 625
  
  GENE3D
  G3DSA:3.30.1370.10 (G3DSA:3.30.1370.10)
2. SSF54791 (Eukaryoti...)
  
  561 - 637
  
  SUPERFAMILY
  SSF54791 (Eukaryotic type KH-domain (KH-domain type I))
IPR012340

Nucleic acid-binding, OB-fold
1. SSF50249 (Nucleic a...)
  
  618 - 701
  
  SUPERFAMILY
  SSF50249 (Nucleic acid-binding proteins)
IPR012162

Polyribonucleotide nucleotidyltransferase
1. TIGR03591
  
  11 - 698
  
  TIGRFAMs
  TIGR03591 (TIGR03591)
2. PTHR11252 (POLYRIBO...)
  
  3 - 704
  
  PANTHER
  PTHR11252 (POLYRIBONUCLEOTIDE NUCLEOTIDYLTRANSFERASE)
3. MF_01595 (PNPase)
  
  3 - 700
  
  HAMAP
  MF_01595 (PNPase)
4. PIRSF005499 (PNPase)
  
  1 - 707
  
  PIRSF
  PIRSF005499 (PNPase)
IPR001247

Exoribonuclease, phosphorolytic domain 1
1. PF01138 (RNase_PH)
  
  14 - 144
  
  Pfam
  PF01138 (RNase_PH)
  
  332 - 465
  
  Pfam
  PF01138 (RNase_PH)
IPR015847

Exoribonuclease, phosphorolytic domain 2
1. PF03725 (RNase_PH_C)
  
  147 - 210
  
  Pfam
  PF03725 (RNase_PH_C)
  
  470 - 536
  
  Pfam
  PF03725 (RNase_PH_C)
IPR015848

Polyribonucleotide nucleotidyltransferase, RNA-binding domain
1. PF03726 (PNPase)
  
  244 - 329
  
  Pfam
  PF03726 (PNPase)
IPR004088

K Homology domain, type 1
1. PF00013 (KH_1)
  
  564 - 607
  
  Pfam
  PF00013 (KH_1)
IPR003029

S1 domain
1. PS50126 (S1)
  
  630 - 697
  
  PROSITE profiles
  PS50126 (S1)
2. PF00575 (S1)
  
  628 - 696
  
  Pfam
  PF00575 (S1)

no IPR

Unintegrated signatures

G3DSA:2.40.50...

630 - 704

GENE3D
G3DSA:2.40.50.140 (G3DSA:2.40.50.140)
PS50084 (KH_TYPE_1)

561 - 620

PROSITE profiles
PS50084 (KH_TYPE_1)
PTHR11252:SF0 (POLY...)

3 - 704

PANTHER
PTHR11252:SF0 (POLYRIBONUCLEOTIDE NUCLEOTIDYLTRANSFERASE 1, MITOCHONDRIAL)
cd02393 (PNPase_KH)

561 - 621

CDD
cd02393 (PNPase_KH)
cd04472 (S1_PNPase)

630 - 696

CDD
cd04472 (S1_PNPase)
cd11363 (RNase_PH_P...)

5 - 233

CDD
cd11363 (RNase_PH_PNPase_1)
cd11364 (RNase_PH_P...)

332 - 553

CDD
cd11364 (RNase_PH_PNPase_2)

Residue annotation

RNase E interface ...

6T

RNase E interface
6T, 8E, 17K, 19S, 22K, 32M, 34Q, 36G, 39V
CDD
cd11363 (RNase_PH_PNPase_1)

8E

RNase E interface
6T, 8E, 17K, 19S, 22K, 32M, 34Q, 36G, 39V
CDD
cd11363 (RNase_PH_PNPase_1)

17K

RNase E interface
6T, 8E, 17K, 19S, 22K, 32M, 34Q, 36G, 39V
CDD
cd11363 (RNase_PH_PNPase_1)

19S

RNase E interface
6T, 8E, 17K, 19S, 22K, 32M, 34Q, 36G, 39V
CDD
cd11363 (RNase_PH_PNPase_1)

22K

RNase E interface
6T, 8E, 17K, 19S, 22K, 32M, 34Q, 36G, 39V
CDD
cd11363 (RNase_PH_PNPase_1)

32M

RNase E interface
6T, 8E, 17K, 19S, 22K, 32M, 34Q, 36G, 39V
CDD
cd11363 (RNase_PH_PNPase_1)

34Q

RNase E interface
6T, 8E, 17K, 19S, 22K, 32M, 34Q, 36G, 39V
CDD
cd11363 (RNase_PH_PNPase_1)

36G

RNase E interface
6T, 8E, 17K, 19S, 22K, 32M, 34Q, 36G, 39V
CDD
cd11363 (RNase_PH_PNPase_1)

39V

RNase E interface
6T, 8E, 17K, 19S, 22K, 32M, 34Q, 36G, 39V
CDD
cd11363 (RNase_PH_PNPase_1)
trimer interface c...

22K

trimer interface
22K, 23I, 24A, 25R, 26Q, 27S, 32M, 41L, 43T, 45N, 47S, 62D, 64I, 66K, 67F, 68Y, 69A, 71G, 72K, 73F, 74P, 77F, 78N, 79K, 80R, 81E, 85S, 110D, 112H, 114V, 118F, 119S, 120F, 121D, 122E
CDD
cd11363 (RNase_PH_PNPase_1)

23I

trimer interface
22K, 23I, 24A, 25R, 26Q, 27S, 32M, 41L, 43T, 45N, 47S, 62D, 64I, 66K, 67F, 68Y, 69A, 71G, 72K, 73F, 74P, 77F, 78N, 79K, 80R, 81E, 85S, 110D, 112H, 114V, 118F, 119S, 120F, 121D, 122E
CDD
cd11363 (RNase_PH_PNPase_1)

24A

trimer interface
22K, 23I, 24A, 25R, 26Q, 27S, 32M, 41L, 43T, 45N, 47S, 62D, 64I, 66K, 67F, 68Y, 69A, 71G, 72K, 73F, 74P, 77F, 78N, 79K, 80R, 81E, 85S, 110D, 112H, 114V, 118F, 119S, 120F, 121D, 122E
CDD
cd11363 (RNase_PH_PNPase_1)

25R

trimer interface
22K, 23I, 24A, 25R, 26Q, 27S, 32M, 41L, 43T, 45N, 47S, 62D, 64I, 66K, 67F, 68Y, 69A, 71G, 72K, 73F, 74P, 77F, 78N, 79K, 80R, 81E, 85S, 110D, 112H, 114V, 118F, 119S, 120F, 121D, 122E
CDD
cd11363 (RNase_PH_PNPase_1)

26Q

trimer interface
22K, 23I, 24A, 25R, 26Q, 27S, 32M, 41L, 43T, 45N, 47S, 62D, 64I, 66K, 67F, 68Y, 69A, 71G, 72K, 73F, 74P, 77F, 78N, 79K, 80R, 81E, 85S, 110D, 112H, 114V, 118F, 119S, 120F, 121D, 122E
CDD
cd11363 (RNase_PH_PNPase_1)

27S

trimer interface
22K, 23I, 24A, 25R, 26Q, 27S, 32M, 41L, 43T, 45N, 47S, 62D, 64I, 66K, 67F, 68Y, 69A, 71G, 72K, 73F, 74P, 77F, 78N, 79K, 80R, 81E, 85S, 110D, 112H, 114V, 118F, 119S, 120F, 121D, 122E
CDD
cd11363 (RNase_PH_PNPase_1)

32M

trimer interface
22K, 23I, 24A, 25R, 26Q, 27S, 32M, 41L, 43T, 45N, 47S, 62D, 64I, 66K, 67F, 68Y, 69A, 71G, 72K, 73F, 74P, 77F, 78N, 79K, 80R, 81E, 85S, 110D, 112H, 114V, 118F, 119S, 120F, 121D, 122E
CDD
cd11363 (RNase_PH_PNPase_1)

41L

trimer interface
22K, 23I, 24A, 25R, 26Q, 27S, 32M, 41L, 43T, 45N, 47S, 62D, 64I, 66K, 67F, 68Y, 69A, 71G, 72K, 73F, 74P, 77F, 78N, 79K, 80R, 81E, 85S, 110D, 112H, 114V, 118F, 119S, 120F, 121D, 122E
CDD
cd11363 (RNase_PH_PNPase_1)

43T

trimer interface
22K, 23I, 24A, 25R, 26Q, 27S, 32M, 41L, 43T, 45N, 47S, 62D, 64I, 66K, 67F, 68Y, 69A, 71G, 72K, 73F, 74P, 77F, 78N, 79K, 80R, 81E, 85S, 110D, 112H, 114V, 118F, 119S, 120F, 121D, 122E
CDD
cd11363 (RNase_PH_PNPase_1)

45N

trimer interface
22K, 23I, 24A, 25R, 26Q, 27S, 32M, 41L, 43T, 45N, 47S, 62D, 64I, 66K, 67F, 68Y, 69A, 71G, 72K, 73F, 74P, 77F, 78N, 79K, 80R, 81E, 85S, 110D, 112H, 114V, 118F, 119S, 120F, 121D, 122E
CDD
cd11363 (RNase_PH_PNPase_1)

47S

trimer interface
22K, 23I, 24A, 25R, 26Q, 27S, 32M, 41L, 43T, 45N, 47S, 62D, 64I, 66K, 67F, 68Y, 69A, 71G, 72K, 73F, 74P, 77F, 78N, 79K, 80R, 81E, 85S, 110D, 112H, 114V, 118F, 119S, 120F, 121D, 122E
CDD
cd11363 (RNase_PH_PNPase_1)

62D

trimer interface
22K, 23I, 24A, 25R, 26Q, 27S, 32M, 41L, 43T, 45N, 47S, 62D, 64I, 66K, 67F, 68Y, 69A, 71G, 72K, 73F, 74P, 77F, 78N, 79K, 80R, 81E, 85S, 110D, 112H, 114V, 118F, 119S, 120F, 121D, 122E
CDD
cd11363 (RNase_PH_PNPase_1)

64I

trimer interface
22K, 23I, 24A, 25R, 26Q, 27S, 32M, 41L, 43T, 45N, 47S, 62D, 64I, 66K, 67F, 68Y, 69A, 71G, 72K, 73F, 74P, 77F, 78N, 79K, 80R, 81E, 85S, 110D, 112H, 114V, 118F, 119S, 120F, 121D, 122E
CDD
cd11363 (RNase_PH_PNPase_1)

66K

trimer interface
22K, 23I, 24A, 25R, 26Q, 27S, 32M, 41L, 43T, 45N, 47S, 62D, 64I, 66K, 67F, 68Y, 69A, 71G, 72K, 73F, 74P, 77F, 78N, 79K, 80R, 81E, 85S, 110D, 112H, 114V, 118F, 119S, 120F, 121D, 122E
CDD
cd11363 (RNase_PH_PNPase_1)

67F

trimer interface
22K, 23I, 24A, 25R, 26Q, 27S, 32M, 41L, 43T, 45N, 47S, 62D, 64I, 66K, 67F, 68Y, 69A, 71G, 72K, 73F, 74P, 77F, 78N, 79K, 80R, 81E, 85S, 110D, 112H, 114V, 118F, 119S, 120F, 121D, 122E
CDD
cd11363 (RNase_PH_PNPase_1)

68Y

trimer interface
22K, 23I, 24A, 25R, 26Q, 27S, 32M, 41L, 43T, 45N, 47S, 62D, 64I, 66K, 67F, 68Y, 69A, 71G, 72K, 73F, 74P, 77F, 78N, 79K, 80R, 81E, 85S, 110D, 112H, 114V, 118F, 119S, 120F, 121D, 122E
CDD
cd11363 (RNase_PH_PNPase_1)

69A

trimer interface
22K, 23I, 24A, 25R, 26Q, 27S, 32M, 41L, 43T, 45N, 47S, 62D, 64I, 66K, 67F, 68Y, 69A, 71G, 72K, 73F, 74P, 77F, 78N, 79K, 80R, 81E, 85S, 110D, 112H, 114V, 118F, 119S, 120F, 121D, 122E
CDD
cd11363 (RNase_PH_PNPase_1)

71G

trimer interface
22K, 23I, 24A, 25R, 26Q, 27S, 32M, 41L, 43T, 45N, 47S, 62D, 64I, 66K, 67F, 68Y, 69A, 71G, 72K, 73F, 74P, 77F, 78N, 79K, 80R, 81E, 85S, 110D, 112H, 114V, 118F, 119S, 120F, 121D, 122E
CDD
cd11363 (RNase_PH_PNPase_1)

72K

trimer interface
22K, 23I, 24A, 25R, 26Q, 27S, 32M, 41L, 43T, 45N, 47S, 62D, 64I, 66K, 67F, 68Y, 69A, 71G, 72K, 73F, 74P, 77F, 78N, 79K, 80R, 81E, 85S, 110D, 112H, 114V, 118F, 119S, 120F, 121D, 122E
CDD
cd11363 (RNase_PH_PNPase_1)

73F

trimer interface
22K, 23I, 24A, 25R, 26Q, 27S, 32M, 41L, 43T, 45N, 47S, 62D, 64I, 66K, 67F, 68Y, 69A, 71G, 72K, 73F, 74P, 77F, 78N, 79K, 80R, 81E, 85S, 110D, 112H, 114V, 118F, 119S, 120F, 121D, 122E
CDD
cd11363 (RNase_PH_PNPase_1)

74P

trimer interface
22K, 23I, 24A, 25R, 26Q, 27S, 32M, 41L, 43T, 45N, 47S, 62D, 64I, 66K, 67F, 68Y, 69A, 71G, 72K, 73F, 74P, 77F, 78N, 79K, 80R, 81E, 85S, 110D, 112H, 114V, 118F, 119S, 120F, 121D, 122E
CDD
cd11363 (RNase_PH_PNPase_1)

77F

trimer interface
22K, 23I, 24A, 25R, 26Q, 27S, 32M, 41L, 43T, 45N, 47S, 62D, 64I, 66K, 67F, 68Y, 69A, 71G, 72K, 73F, 74P, 77F, 78N, 79K, 80R, 81E, 85S, 110D, 112H, 114V, 118F, 119S, 120F, 121D, 122E
CDD
cd11363 (RNase_PH_PNPase_1)

78N

trimer interface
22K, 23I, 24A, 25R, 26Q, 27S, 32M, 41L, 43T, 45N, 47S, 62D, 64I, 66K, 67F, 68Y, 69A, 71G, 72K, 73F, 74P, 77F, 78N, 79K, 80R, 81E, 85S, 110D, 112H, 114V, 118F, 119S, 120F, 121D, 122E
CDD
cd11363 (RNase_PH_PNPase_1)

79K

trimer interface
22K, 23I, 24A, 25R, 26Q, 27S, 32M, 41L, 43T, 45N, 47S, 62D, 64I, 66K, 67F, 68Y, 69A, 71G, 72K, 73F, 74P, 77F, 78N, 79K, 80R, 81E, 85S, 110D, 112H, 114V, 118F, 119S, 120F, 121D, 122E
CDD
cd11363 (RNase_PH_PNPase_1)

80R

trimer interface
22K, 23I, 24A, 25R, 26Q, 27S, 32M, 41L, 43T, 45N, 47S, 62D, 64I, 66K, 67F, 68Y, 69A, 71G, 72K, 73F, 74P, 77F, 78N, 79K, 80R, 81E, 85S, 110D, 112H, 114V, 118F, 119S, 120F, 121D, 122E
CDD
cd11363 (RNase_PH_PNPase_1)

81E

trimer interface
22K, 23I, 24A, 25R, 26Q, 27S, 32M, 41L, 43T, 45N, 47S, 62D, 64I, 66K, 67F, 68Y, 69A, 71G, 72K, 73F, 74P, 77F, 78N, 79K, 80R, 81E, 85S, 110D, 112H, 114V, 118F, 119S, 120F, 121D, 122E
CDD
cd11363 (RNase_PH_PNPase_1)

85S

trimer interface
22K, 23I, 24A, 25R, 26Q, 27S, 32M, 41L, 43T, 45N, 47S, 62D, 64I, 66K, 67F, 68Y, 69A, 71G, 72K, 73F, 74P, 77F, 78N, 79K, 80R, 81E, 85S, 110D, 112H, 114V, 118F, 119S, 120F, 121D, 122E
CDD
cd11363 (RNase_PH_PNPase_1)

110D

trimer interface
22K, 23I, 24A, 25R, 26Q, 27S, 32M, 41L, 43T, 45N, 47S, 62D, 64I, 66K, 67F, 68Y, 69A, 71G, 72K, 73F, 74P, 77F, 78N, 79K, 80R, 81E, 85S, 110D, 112H, 114V, 118F, 119S, 120F, 121D, 122E
CDD
cd11363 (RNase_PH_PNPase_1)

112H

trimer interface
22K, 23I, 24A, 25R, 26Q, 27S, 32M, 41L, 43T, 45N, 47S, 62D, 64I, 66K, 67F, 68Y, 69A, 71G, 72K, 73F, 74P, 77F, 78N, 79K, 80R, 81E, 85S, 110D, 112H, 114V, 118F, 119S, 120F, 121D, 122E
CDD
cd11363 (RNase_PH_PNPase_1)

114V

trimer interface
22K, 23I, 24A, 25R, 26Q, 27S, 32M, 41L, 43T, 45N, 47S, 62D, 64I, 66K, 67F, 68Y, 69A, 71G, 72K, 73F, 74P, 77F, 78N, 79K, 80R, 81E, 85S, 110D, 112H, 114V, 118F, 119S, 120F, 121D, 122E
CDD
cd11363 (RNase_PH_PNPase_1)

118F

trimer interface
22K, 23I, 24A, 25R, 26Q, 27S, 32M, 41L, 43T, 45N, 47S, 62D, 64I, 66K, 67F, 68Y, 69A, 71G, 72K, 73F, 74P, 77F, 78N, 79K, 80R, 81E, 85S, 110D, 112H, 114V, 118F, 119S, 120F, 121D, 122E
CDD
cd11363 (RNase_PH_PNPase_1)

119S

trimer interface
22K, 23I, 24A, 25R, 26Q, 27S, 32M, 41L, 43T, 45N, 47S, 62D, 64I, 66K, 67F, 68Y, 69A, 71G, 72K, 73F, 74P, 77F, 78N, 79K, 80R, 81E, 85S, 110D, 112H, 114V, 118F, 119S, 120F, 121D, 122E
CDD
cd11363 (RNase_PH_PNPase_1)

120F

trimer interface
22K, 23I, 24A, 25R, 26Q, 27S, 32M, 41L, 43T, 45N, 47S, 62D, 64I, 66K, 67F, 68Y, 69A, 71G, 72K, 73F, 74P, 77F, 78N, 79K, 80R, 81E, 85S, 110D, 112H, 114V, 118F, 119S, 120F, 121D, 122E
CDD
cd11363 (RNase_PH_PNPase_1)

121D

trimer interface
22K, 23I, 24A, 25R, 26Q, 27S, 32M, 41L, 43T, 45N, 47S, 62D, 64I, 66K, 67F, 68Y, 69A, 71G, 72K, 73F, 74P, 77F, 78N, 79K, 80R, 81E, 85S, 110D, 112H, 114V, 118F, 119S, 120F, 121D, 122E
CDD
cd11363 (RNase_PH_PNPase_1)

122E

trimer interface
22K, 23I, 24A, 25R, 26Q, 27S, 32M, 41L, 43T, 45N, 47S, 62D, 64I, 66K, 67F, 68Y, 69A, 71G, 72K, 73F, 74P, 77F, 78N, 79K, 80R, 81E, 85S, 110D, 112H, 114V, 118F, 119S, 120F, 121D, 122E
CDD
cd11363 (RNase_PH_PNPase_1)
RNase E interface ...

332E

RNase E interface
332E, 333I, 334R, 335P, 336L, 337D, 338A, 339Q, 340I, 341N, 344P, 537V, 541Q, 545V, 549A, 550I
CDD
cd11364 (RNase_PH_PNPase_2)

333I

RNase E interface
332E, 333I, 334R, 335P, 336L, 337D, 338A, 339Q, 340I, 341N, 344P, 537V, 541Q, 545V, 549A, 550I
CDD
cd11364 (RNase_PH_PNPase_2)

334R

RNase E interface
332E, 333I, 334R, 335P, 336L, 337D, 338A, 339Q, 340I, 341N, 344P, 537V, 541Q, 545V, 549A, 550I
CDD
cd11364 (RNase_PH_PNPase_2)

335P

RNase E interface
332E, 333I, 334R, 335P, 336L, 337D, 338A, 339Q, 340I, 341N, 344P, 537V, 541Q, 545V, 549A, 550I
CDD
cd11364 (RNase_PH_PNPase_2)

336L

RNase E interface
332E, 333I, 334R, 335P, 336L, 337D, 338A, 339Q, 340I, 341N, 344P, 537V, 541Q, 545V, 549A, 550I
CDD
cd11364 (RNase_PH_PNPase_2)

337D

RNase E interface
332E, 333I, 334R, 335P, 336L, 337D, 338A, 339Q, 340I, 341N, 344P, 537V, 541Q, 545V, 549A, 550I
CDD
cd11364 (RNase_PH_PNPase_2)

338A

RNase E interface
332E, 333I, 334R, 335P, 336L, 337D, 338A, 339Q, 340I, 341N, 344P, 537V, 541Q, 545V, 549A, 550I
CDD
cd11364 (RNase_PH_PNPase_2)

339Q

RNase E interface
332E, 333I, 334R, 335P, 336L, 337D, 338A, 339Q, 340I, 341N, 344P, 537V, 541Q, 545V, 549A, 550I
CDD
cd11364 (RNase_PH_PNPase_2)

340I

RNase E interface
332E, 333I, 334R, 335P, 336L, 337D, 338A, 339Q, 340I, 341N, 344P, 537V, 541Q, 545V, 549A, 550I
CDD
cd11364 (RNase_PH_PNPase_2)

341N

RNase E interface
332E, 333I, 334R, 335P, 336L, 337D, 338A, 339Q, 340I, 341N, 344P, 537V, 541Q, 545V, 549A, 550I
CDD
cd11364 (RNase_PH_PNPase_2)

344P

RNase E interface
332E, 333I, 334R, 335P, 336L, 337D, 338A, 339Q, 340I, 341N, 344P, 537V, 541Q, 545V, 549A, 550I
CDD
cd11364 (RNase_PH_PNPase_2)

537V

RNase E interface
332E, 333I, 334R, 335P, 336L, 337D, 338A, 339Q, 340I, 341N, 344P, 537V, 541Q, 545V, 549A, 550I
CDD
cd11364 (RNase_PH_PNPase_2)

541Q

RNase E interface
332E, 333I, 334R, 335P, 336L, 337D, 338A, 339Q, 340I, 341N, 344P, 537V, 541Q, 545V, 549A, 550I
CDD
cd11364 (RNase_PH_PNPase_2)

545V

RNase E interface
332E, 333I, 334R, 335P, 336L, 337D, 338A, 339Q, 340I, 341N, 344P, 537V, 541Q, 545V, 549A, 550I
CDD
cd11364 (RNase_PH_PNPase_2)

549A

RNase E interface
332E, 333I, 334R, 335P, 336L, 337D, 338A, 339Q, 340I, 341N, 344P, 537V, 541Q, 545V, 549A, 550I
CDD
cd11364 (RNase_PH_PNPase_2)

550I

RNase E interface
332E, 333I, 334R, 335P, 336L, 337D, 338A, 339Q, 340I, 341N, 344P, 537V, 541Q, 545V, 549A, 550I
CDD
cd11364 (RNase_PH_PNPase_2)
trimer interface c...

337D

trimer interface
337D, 339Q, 343L, 344P, 345I, 346P, 347H, 355G, 356E, 360L, 362T, 364T, 365L, 366G, 370D, 371E, 372Q, 388H, 390N, 393P, 394Y, 395S, 396V, 398E, 399T, 400G, 403G, 405P, 435R, 437V, 439D, 441T, 442E, 443S
CDD
cd11364 (RNase_PH_PNPase_2)

339Q

trimer interface
337D, 339Q, 343L, 344P, 345I, 346P, 347H, 355G, 356E, 360L, 362T, 364T, 365L, 366G, 370D, 371E, 372Q, 388H, 390N, 393P, 394Y, 395S, 396V, 398E, 399T, 400G, 403G, 405P, 435R, 437V, 439D, 441T, 442E, 443S
CDD
cd11364 (RNase_PH_PNPase_2)

343L

trimer interface
337D, 339Q, 343L, 344P, 345I, 346P, 347H, 355G, 356E, 360L, 362T, 364T, 365L, 366G, 370D, 371E, 372Q, 388H, 390N, 393P, 394Y, 395S, 396V, 398E, 399T, 400G, 403G, 405P, 435R, 437V, 439D, 441T, 442E, 443S
CDD
cd11364 (RNase_PH_PNPase_2)

344P

trimer interface
337D, 339Q, 343L, 344P, 345I, 346P, 347H, 355G, 356E, 360L, 362T, 364T, 365L, 366G, 370D, 371E, 372Q, 388H, 390N, 393P, 394Y, 395S, 396V, 398E, 399T, 400G, 403G, 405P, 435R, 437V, 439D, 441T, 442E, 443S
CDD
cd11364 (RNase_PH_PNPase_2)

345I

trimer interface
337D, 339Q, 343L, 344P, 345I, 346P, 347H, 355G, 356E, 360L, 362T, 364T, 365L, 366G, 370D, 371E, 372Q, 388H, 390N, 393P, 394Y, 395S, 396V, 398E, 399T, 400G, 403G, 405P, 435R, 437V, 439D, 441T, 442E, 443S
CDD
cd11364 (RNase_PH_PNPase_2)

346P

trimer interface
337D, 339Q, 343L, 344P, 345I, 346P, 347H, 355G, 356E, 360L, 362T, 364T, 365L, 366G, 370D, 371E, 372Q, 388H, 390N, 393P, 394Y, 395S, 396V, 398E, 399T, 400G, 403G, 405P, 435R, 437V, 439D, 441T, 442E, 443S
CDD
cd11364 (RNase_PH_PNPase_2)

347H

trimer interface
337D, 339Q, 343L, 344P, 345I, 346P, 347H, 355G, 356E, 360L, 362T, 364T, 365L, 366G, 370D, 371E, 372Q, 388H, 390N, 393P, 394Y, 395S, 396V, 398E, 399T, 400G, 403G, 405P, 435R, 437V, 439D, 441T, 442E, 443S
CDD
cd11364 (RNase_PH_PNPase_2)

355G

trimer interface
337D, 339Q, 343L, 344P, 345I, 346P, 347H, 355G, 356E, 360L, 362T, 364T, 365L, 366G, 370D, 371E, 372Q, 388H, 390N, 393P, 394Y, 395S, 396V, 398E, 399T, 400G, 403G, 405P, 435R, 437V, 439D, 441T, 442E, 443S
CDD
cd11364 (RNase_PH_PNPase_2)

356E

trimer interface
337D, 339Q, 343L, 344P, 345I, 346P, 347H, 355G, 356E, 360L, 362T, 364T, 365L, 366G, 370D, 371E, 372Q, 388H, 390N, 393P, 394Y, 395S, 396V, 398E, 399T, 400G, 403G, 405P, 435R, 437V, 439D, 441T, 442E, 443S
CDD
cd11364 (RNase_PH_PNPase_2)

360L

trimer interface
337D, 339Q, 343L, 344P, 345I, 346P, 347H, 355G, 356E, 360L, 362T, 364T, 365L, 366G, 370D, 371E, 372Q, 388H, 390N, 393P, 394Y, 395S, 396V, 398E, 399T, 400G, 403G, 405P, 435R, 437V, 439D, 441T, 442E, 443S
CDD
cd11364 (RNase_PH_PNPase_2)

362T

trimer interface
337D, 339Q, 343L, 344P, 345I, 346P, 347H, 355G, 356E, 360L, 362T, 364T, 365L, 366G, 370D, 371E, 372Q, 388H, 390N, 393P, 394Y, 395S, 396V, 398E, 399T, 400G, 403G, 405P, 435R, 437V, 439D, 441T, 442E, 443S
CDD
cd11364 (RNase_PH_PNPase_2)

364T

trimer interface
337D, 339Q, 343L, 344P, 345I, 346P, 347H, 355G, 356E, 360L, 362T, 364T, 365L, 366G, 370D, 371E, 372Q, 388H, 390N, 393P, 394Y, 395S, 396V, 398E, 399T, 400G, 403G, 405P, 435R, 437V, 439D, 441T, 442E, 443S
CDD
cd11364 (RNase_PH_PNPase_2)

365L

trimer interface
337D, 339Q, 343L, 344P, 345I, 346P, 347H, 355G, 356E, 360L, 362T, 364T, 365L, 366G, 370D, 371E, 372Q, 388H, 390N, 393P, 394Y, 395S, 396V, 398E, 399T, 400G, 403G, 405P, 435R, 437V, 439D, 441T, 442E, 443S
CDD
cd11364 (RNase_PH_PNPase_2)

366G

trimer interface
337D, 339Q, 343L, 344P, 345I, 346P, 347H, 355G, 356E, 360L, 362T, 364T, 365L, 366G, 370D, 371E, 372Q, 388H, 390N, 393P, 394Y, 395S, 396V, 398E, 399T, 400G, 403G, 405P, 435R, 437V, 439D, 441T, 442E, 443S
CDD
cd11364 (RNase_PH_PNPase_2)

370D

trimer interface
337D, 339Q, 343L, 344P, 345I, 346P, 347H, 355G, 356E, 360L, 362T, 364T, 365L, 366G, 370D, 371E, 372Q, 388H, 390N, 393P, 394Y, 395S, 396V, 398E, 399T, 400G, 403G, 405P, 435R, 437V, 439D, 441T, 442E, 443S
CDD
cd11364 (RNase_PH_PNPase_2)

371E

trimer interface
337D, 339Q, 343L, 344P, 345I, 346P, 347H, 355G, 356E, 360L, 362T, 364T, 365L, 366G, 370D, 371E, 372Q, 388H, 390N, 393P, 394Y, 395S, 396V, 398E, 399T, 400G, 403G, 405P, 435R, 437V, 439D, 441T, 442E, 443S
CDD
cd11364 (RNase_PH_PNPase_2)

372Q

trimer interface
337D, 339Q, 343L, 344P, 345I, 346P, 347H, 355G, 356E, 360L, 362T, 364T, 365L, 366G, 370D, 371E, 372Q, 388H, 390N, 393P, 394Y, 395S, 396V, 398E, 399T, 400G, 403G, 405P, 435R, 437V, 439D, 441T, 442E, 443S
CDD
cd11364 (RNase_PH_PNPase_2)

388H

trimer interface
337D, 339Q, 343L, 344P, 345I, 346P, 347H, 355G, 356E, 360L, 362T, 364T, 365L, 366G, 370D, 371E, 372Q, 388H, 390N, 393P, 394Y, 395S, 396V, 398E, 399T, 400G, 403G, 405P, 435R, 437V, 439D, 441T, 442E, 443S
CDD
cd11364 (RNase_PH_PNPase_2)

390N

trimer interface
337D, 339Q, 343L, 344P, 345I, 346P, 347H, 355G, 356E, 360L, 362T, 364T, 365L, 366G, 370D, 371E, 372Q, 388H, 390N, 393P, 394Y, 395S, 396V, 398E, 399T, 400G, 403G, 405P, 435R, 437V, 439D, 441T, 442E, 443S
CDD
cd11364 (RNase_PH_PNPase_2)

393P

trimer interface
337D, 339Q, 343L, 344P, 345I, 346P, 347H, 355G, 356E, 360L, 362T, 364T, 365L, 366G, 370D, 371E, 372Q, 388H, 390N, 393P, 394Y, 395S, 396V, 398E, 399T, 400G, 403G, 405P, 435R, 437V, 439D, 441T, 442E, 443S
CDD
cd11364 (RNase_PH_PNPase_2)

394Y

trimer interface
337D, 339Q, 343L, 344P, 345I, 346P, 347H, 355G, 356E, 360L, 362T, 364T, 365L, 366G, 370D, 371E, 372Q, 388H, 390N, 393P, 394Y, 395S, 396V, 398E, 399T, 400G, 403G, 405P, 435R, 437V, 439D, 441T, 442E, 443S
CDD
cd11364 (RNase_PH_PNPase_2)

395S

trimer interface
337D, 339Q, 343L, 344P, 345I, 346P, 347H, 355G, 356E, 360L, 362T, 364T, 365L, 366G, 370D, 371E, 372Q, 388H, 390N, 393P, 394Y, 395S, 396V, 398E, 399T, 400G, 403G, 405P, 435R, 437V, 439D, 441T, 442E, 443S
CDD
cd11364 (RNase_PH_PNPase_2)

396V

trimer interface
337D, 339Q, 343L, 344P, 345I, 346P, 347H, 355G, 356E, 360L, 362T, 364T, 365L, 366G, 370D, 371E, 372Q, 388H, 390N, 393P, 394Y, 395S, 396V, 398E, 399T, 400G, 403G, 405P, 435R, 437V, 439D, 441T, 442E, 443S
CDD
cd11364 (RNase_PH_PNPase_2)

398E

trimer interface
337D, 339Q, 343L, 344P, 345I, 346P, 347H, 355G, 356E, 360L, 362T, 364T, 365L, 366G, 370D, 371E, 372Q, 388H, 390N, 393P, 394Y, 395S, 396V, 398E, 399T, 400G, 403G, 405P, 435R, 437V, 439D, 441T, 442E, 443S
CDD
cd11364 (RNase_PH_PNPase_2)

399T

trimer interface
337D, 339Q, 343L, 344P, 345I, 346P, 347H, 355G, 356E, 360L, 362T, 364T, 365L, 366G, 370D, 371E, 372Q, 388H, 390N, 393P, 394Y, 395S, 396V, 398E, 399T, 400G, 403G, 405P, 435R, 437V, 439D, 441T, 442E, 443S
CDD
cd11364 (RNase_PH_PNPase_2)

400G

trimer interface
337D, 339Q, 343L, 344P, 345I, 346P, 347H, 355G, 356E, 360L, 362T, 364T, 365L, 366G, 370D, 371E, 372Q, 388H, 390N, 393P, 394Y, 395S, 396V, 398E, 399T, 400G, 403G, 405P, 435R, 437V, 439D, 441T, 442E, 443S
CDD
cd11364 (RNase_PH_PNPase_2)

403G

trimer interface
337D, 339Q, 343L, 344P, 345I, 346P, 347H, 355G, 356E, 360L, 362T, 364T, 365L, 366G, 370D, 371E, 372Q, 388H, 390N, 393P, 394Y, 395S, 396V, 398E, 399T, 400G, 403G, 405P, 435R, 437V, 439D, 441T, 442E, 443S
CDD
cd11364 (RNase_PH_PNPase_2)

405P

trimer interface
337D, 339Q, 343L, 344P, 345I, 346P, 347H, 355G, 356E, 360L, 362T, 364T, 365L, 366G, 370D, 371E, 372Q, 388H, 390N, 393P, 394Y, 395S, 396V, 398E, 399T, 400G, 403G, 405P, 435R, 437V, 439D, 441T, 442E, 443S
CDD
cd11364 (RNase_PH_PNPase_2)

435R

trimer interface
337D, 339Q, 343L, 344P, 345I, 346P, 347H, 355G, 356E, 360L, 362T, 364T, 365L, 366G, 370D, 371E, 372Q, 388H, 390N, 393P, 394Y, 395S, 396V, 398E, 399T, 400G, 403G, 405P, 435R, 437V, 439D, 441T, 442E, 443S
CDD
cd11364 (RNase_PH_PNPase_2)

437V

trimer interface
337D, 339Q, 343L, 344P, 345I, 346P, 347H, 355G, 356E, 360L, 362T, 364T, 365L, 366G, 370D, 371E, 372Q, 388H, 390N, 393P, 394Y, 395S, 396V, 398E, 399T, 400G, 403G, 405P, 435R, 437V, 439D, 441T, 442E, 443S
CDD
cd11364 (RNase_PH_PNPase_2)

439D

trimer interface
337D, 339Q, 343L, 344P, 345I, 346P, 347H, 355G, 356E, 360L, 362T, 364T, 365L, 366G, 370D, 371E, 372Q, 388H, 390N, 393P, 394Y, 395S, 396V, 398E, 399T, 400G, 403G, 405P, 435R, 437V, 439D, 441T, 442E, 443S
CDD
cd11364 (RNase_PH_PNPase_2)

441T

trimer interface
337D, 339Q, 343L, 344P, 345I, 346P, 347H, 355G, 356E, 360L, 362T, 364T, 365L, 366G, 370D, 371E, 372Q, 388H, 390N, 393P, 394Y, 395S, 396V, 398E, 399T, 400G, 403G, 405P, 435R, 437V, 439D, 441T, 442E, 443S
CDD
cd11364 (RNase_PH_PNPase_2)

442E

trimer interface
337D, 339Q, 343L, 344P, 345I, 346P, 347H, 355G, 356E, 360L, 362T, 364T, 365L, 366G, 370D, 371E, 372Q, 388H, 390N, 393P, 394Y, 395S, 396V, 398E, 399T, 400G, 403G, 405P, 435R, 437V, 439D, 441T, 442E, 443S
CDD
cd11364 (RNase_PH_PNPase_2)

443S

trimer interface
337D, 339Q, 343L, 344P, 345I, 346P, 347H, 355G, 356E, 360L, 362T, 364T, 365L, 366G, 370D, 371E, 372Q, 388H, 390N, 393P, 394Y, 395S, 396V, 398E, 399T, 400G, 403G, 405P, 435R, 437V, 439D, 441T, 442E, 443S
CDD
cd11364 (RNase_PH_PNPase_2)
active site cd11364

389Y

active site
389Y, 391F, 408R, 412H, 446S, 447S, 448S, 495D, 501D, 503K, 515Q, 517D
CDD
cd11364 (RNase_PH_PNPase_2)

391F

active site
389Y, 391F, 408R, 412H, 446S, 447S, 448S, 495D, 501D, 503K, 515Q, 517D
CDD
cd11364 (RNase_PH_PNPase_2)

408R

active site
389Y, 391F, 408R, 412H, 446S, 447S, 448S, 495D, 501D, 503K, 515Q, 517D
CDD
cd11364 (RNase_PH_PNPase_2)

412H

active site
389Y, 391F, 408R, 412H, 446S, 447S, 448S, 495D, 501D, 503K, 515Q, 517D
CDD
cd11364 (RNase_PH_PNPase_2)

446S

active site
389Y, 391F, 408R, 412H, 446S, 447S, 448S, 495D, 501D, 503K, 515Q, 517D
CDD
cd11364 (RNase_PH_PNPase_2)

447S

active site
389Y, 391F, 408R, 412H, 446S, 447S, 448S, 495D, 501D, 503K, 515Q, 517D
CDD
cd11364 (RNase_PH_PNPase_2)

448S

active site
389Y, 391F, 408R, 412H, 446S, 447S, 448S, 495D, 501D, 503K, 515Q, 517D
CDD
cd11364 (RNase_PH_PNPase_2)

495D

active site
389Y, 391F, 408R, 412H, 446S, 447S, 448S, 495D, 501D, 503K, 515Q, 517D
CDD
cd11364 (RNase_PH_PNPase_2)

501D

active site
389Y, 391F, 408R, 412H, 446S, 447S, 448S, 495D, 501D, 503K, 515Q, 517D
CDD
cd11364 (RNase_PH_PNPase_2)

503K

active site
389Y, 391F, 408R, 412H, 446S, 447S, 448S, 495D, 501D, 503K, 515Q, 517D
CDD
cd11364 (RNase_PH_PNPase_2)

515Q

active site
389Y, 391F, 408R, 412H, 446S, 447S, 448S, 495D, 501D, 503K, 515Q, 517D
CDD
cd11364 (RNase_PH_PNPase_2)

517D

active site
389Y, 391F, 408R, 412H, 446S, 447S, 448S, 495D, 501D, 503K, 515Q, 517D
CDD
cd11364 (RNase_PH_PNPase_2)
putative nucleic a...

571D

putative nucleic acid binding region
571D, 573I, 574A, 575I, 577I, 578G, 579P, 580G, 581G, 584I, 585K, 588I, 589E, 594T, 595I, 596D, 597I
CDD
cd02393 (PNPase_KH)

573I

putative nucleic acid binding region
571D, 573I, 574A, 575I, 577I, 578G, 579P, 580G, 581G, 584I, 585K, 588I, 589E, 594T, 595I, 596D, 597I
CDD
cd02393 (PNPase_KH)

574A

putative nucleic acid binding region
571D, 573I, 574A, 575I, 577I, 578G, 579P, 580G, 581G, 584I, 585K, 588I, 589E, 594T, 595I, 596D, 597I
CDD
cd02393 (PNPase_KH)

575I

putative nucleic acid binding region
571D, 573I, 574A, 575I, 577I, 578G, 579P, 580G, 581G, 584I, 585K, 588I, 589E, 594T, 595I, 596D, 597I
CDD
cd02393 (PNPase_KH)

577I

putative nucleic acid binding region
571D, 573I, 574A, 575I, 577I, 578G, 579P, 580G, 581G, 584I, 585K, 588I, 589E, 594T, 595I, 596D, 597I
CDD
cd02393 (PNPase_KH)

578G

putative nucleic acid binding region
571D, 573I, 574A, 575I, 577I, 578G, 579P, 580G, 581G, 584I, 585K, 588I, 589E, 594T, 595I, 596D, 597I
CDD
cd02393 (PNPase_KH)

579P

putative nucleic acid binding region
571D, 573I, 574A, 575I, 577I, 578G, 579P, 580G, 581G, 584I, 585K, 588I, 589E, 594T, 595I, 596D, 597I
CDD
cd02393 (PNPase_KH)

580G

putative nucleic acid binding region
571D, 573I, 574A, 575I, 577I, 578G, 579P, 580G, 581G, 584I, 585K, 588I, 589E, 594T, 595I, 596D, 597I
CDD
cd02393 (PNPase_KH)

581G

putative nucleic acid binding region
571D, 573I, 574A, 575I, 577I, 578G, 579P, 580G, 581G, 584I, 585K, 588I, 589E, 594T, 595I, 596D, 597I
CDD
cd02393 (PNPase_KH)

584I

putative nucleic acid binding region
571D, 573I, 574A, 575I, 577I, 578G, 579P, 580G, 581G, 584I, 585K, 588I, 589E, 594T, 595I, 596D, 597I
CDD
cd02393 (PNPase_KH)

585K

putative nucleic acid binding region
571D, 573I, 574A, 575I, 577I, 578G, 579P, 580G, 581G, 584I, 585K, 588I, 589E, 594T, 595I, 596D, 597I
CDD
cd02393 (PNPase_KH)

588I

putative nucleic acid binding region
571D, 573I, 574A, 575I, 577I, 578G, 579P, 580G, 581G, 584I, 585K, 588I, 589E, 594T, 595I, 596D, 597I
CDD
cd02393 (PNPase_KH)

589E

putative nucleic acid binding region
571D, 573I, 574A, 575I, 577I, 578G, 579P, 580G, 581G, 584I, 585K, 588I, 589E, 594T, 595I, 596D, 597I
CDD
cd02393 (PNPase_KH)

594T

putative nucleic acid binding region
571D, 573I, 574A, 575I, 577I, 578G, 579P, 580G, 581G, 584I, 585K, 588I, 589E, 594T, 595I, 596D, 597I
CDD
cd02393 (PNPase_KH)

595I

putative nucleic acid binding region
571D, 573I, 574A, 575I, 577I, 578G, 579P, 580G, 581G, 584I, 585K, 588I, 589E, 594T, 595I, 596D, 597I
CDD
cd02393 (PNPase_KH)

596D

putative nucleic acid binding region
571D, 573I, 574A, 575I, 577I, 578G, 579P, 580G, 581G, 584I, 585K, 588I, 589E, 594T, 595I, 596D, 597I
CDD
cd02393 (PNPase_KH)

597I

putative nucleic acid binding region
571D, 573I, 574A, 575I, 577I, 578G, 579P, 580G, 581G, 584I, 585K, 588I, 589E, 594T, 595I, 596D, 597I
CDD
cd02393 (PNPase_KH)
G-X-X-G motif cd02...

578G

G-X-X-G motif
578G, 579P, 580G, 581G
CDD
cd02393 (PNPase_KH)

579P

G-X-X-G motif
578G, 579P, 580G, 581G
CDD
cd02393 (PNPase_KH)

580G

G-X-X-G motif
578G, 579P, 580G, 581G
CDD
cd02393 (PNPase_KH)

581G

G-X-X-G motif
578G, 579P, 580G, 581G
CDD
cd02393 (PNPase_KH)
RNA binding site c...

638V

RNA binding site
638V, 646F, 656L, 658H
CDD
cd04472 (S1_PNPase)

646F

RNA binding site
638V, 646F, 656L, 658H
CDD
cd04472 (S1_PNPase)

656L

RNA binding site
638V, 646F, 656L, 658H
CDD
cd04472 (S1_PNPase)

658H

RNA binding site
638V, 646F, 656L, 658H
CDD
cd04472 (S1_PNPase)
domain interface c...

677G

domain interface
677G, 678D
CDD
cd04472 (S1_PNPase)

678D

domain interface
677G, 678D
CDD
cd04472 (S1_PNPase)

GO term prediction

Biological Process

GO:0006396 RNA processing
GO:0006402 mRNA catabolic process

Molecular Function

GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0004654 polyribonucleotide nucleotidyltransferase activity

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features

25563_FusoPortal_Gene_1060

Protein family membership

Homologous superfamilies

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component