25563_FusoPortal_Gene_1125

Protein

25563_FusoPortal_Gene_1125

Length

328 amino acids

Protein family membership

Asparaginase/glutaminase-like (IPR006034)
- L-asparaginase, type I (IPR006033)

Homologous superfamilies

Homologous superfamily
1 - 201
L-asparaginase, N-terminal domain superfamily (IPR037152)
203 - 328
L-asparaginase, C-terminal (IPR027473)
Homologous superfamily
2 - 328
Asparaginase/glutaminase-like superfamily (IPR036152)

1 50 100 150 200 250 300 328

Domains and repeats

Domain
4 - 186
L-asparaginase, N-terminal (IPR027474)

1 50 100 150 200 250 300 328

Detailed signature matches

IPR037152

L-asparaginase, N-terminal domain superfamily
1. G3DSA:3.40.50...
  
  1 - 201
  
  GENE3D
  G3DSA:3.40.50.1170 (G3DSA:3.40.50.1170)
IPR036152

Asparaginase/glutaminase-like superfamily
1. SSF53774 (Glutamina...)
  
  2 - 328
  
  SUPERFAMILY
  SSF53774 (Glutaminase/Asparaginase)
IPR027473

L-asparaginase, C-terminal
1. G3DSA:3.40.50.40
  
  203 - 328
  
  GENE3D
  G3DSA:3.40.50.40 (G3DSA:3.40.50.40)
IPR006034

Asparaginase/glutaminase-like
1. PIRSF001220 (L-ASNa...)
  
  1 - 327
  
  PIRSF
  PIRSF001220 (L-ASNase_gatD)
2. PR00139 (ASNGLNASE)
  
  76 - 94
  
  PRINTS
  PR00139 (ASNGLNASE)
  
  253 - 271
  
  PRINTS
  PR00139 (ASNGLNASE)
  
  5 - 16
  
  PRINTS
  PR00139 (ASNGLNASE)
3. PS51732 (ASN_GLN_ASE_3)
  
  3 - 322
  
  PROSITE profiles
  PS51732 (ASN_GLN_ASE_3)
IPR006033

L-asparaginase, type I
1. TIGR00519
  
  4 - 327
  
  TIGRFAMs
  TIGR00519 (TIGR00519)
IPR027474

L-asparaginase, N-terminal
1. PF00710 (Asparaginase)
  
  4 - 186
  
  Pfam
  PF00710 (Asparaginase)
IPR020827

Asparaginase/glutaminase, active site 1
1. PS00144 (ASN_GLN_ASE_1)
  
  7 - 15
  
  PROSITE patterns
  PS00144 (ASN_GLN_ASE_1)
IPR027475

Asparaginase/glutaminase, active site 2
1. PS00917 (ASN_GLN_ASE_2)
  
  77 - 87
  
  PROSITE patterns
  PS00917 (ASN_GLN_ASE_2)

no IPR

Unintegrated signatures

PIRSF500176 (L_ASNase)

1 - 325

PIRSF
PIRSF500176 (L_ASNase)
PTHR11707 (L-ASPARA...)

2 - 327

PANTHER
PTHR11707 (L-ASPARAGINASE)
PTHR11707:SF28 (60 ...)

2 - 327

PANTHER
PTHR11707:SF28 (60 KDA LYSOPHOSPHOLIPASE)
SFLDS00057 (Glutami...)

2 - 327

SFLD
SFLDS00057 (Glutaminase/Asparaginase)
cd08963 (L-asparagi...)

3 - 317

CDD
cd08963 (L-asparaginase_I)

Residue annotation

active site cd08963

12G

active site
12G, 13T, 53S, 54S, 83G, 84T, 85D, 110S, 156K
CDD
cd08963 (L-asparaginase_I)

13T

active site
12G, 13T, 53S, 54S, 83G, 84T, 85D, 110S, 156K
CDD
cd08963 (L-asparaginase_I)

53S

active site
12G, 13T, 53S, 54S, 83G, 84T, 85D, 110S, 156K
CDD
cd08963 (L-asparaginase_I)

54S

active site
12G, 13T, 53S, 54S, 83G, 84T, 85D, 110S, 156K
CDD
cd08963 (L-asparaginase_I)

83G

active site
12G, 13T, 53S, 54S, 83G, 84T, 85D, 110S, 156K
CDD
cd08963 (L-asparaginase_I)

84T

active site
12G, 13T, 53S, 54S, 83G, 84T, 85D, 110S, 156K
CDD
cd08963 (L-asparaginase_I)

85D

active site
12G, 13T, 53S, 54S, 83G, 84T, 85D, 110S, 156K
CDD
cd08963 (L-asparaginase_I)

110S

active site
12G, 13T, 53S, 54S, 83G, 84T, 85D, 110S, 156K
CDD
cd08963 (L-asparaginase_I)

156K

active site
12G, 13T, 53S, 54S, 83G, 84T, 85D, 110S, 156K
CDD
cd08963 (L-asparaginase_I)
SFLDS00057

13T

SFLD_Res01
13T, 108T
SFLD
SFLDS00057 (Glutaminase/Asparaginase)

108T

SFLD_Res01
13T, 108T
SFLD
SFLDS00057 (Glutaminase/Asparaginase)
homodimer interfac...

13T

homodimer interface
13T, 20P, 21L, 22Q, 49N, 52D, 53S, 54S, 55D, 56M, 57N, 58P, 60I, 61W, 85D, 86T, 89Y, 111Q, 112V, 156K, 157I, 158D, 159A, 160T, 161N, 204D, 205I, 206I, 207V, 208L, 209E, 210I, 211F, 212P, 213G, 214M, 216I, 217E, 220N, 223L, 224N, 233K, 235F, 236G, 237N, 241P, 265Q, 268R, 269G, 270S, 271V, 272E, 276Y, 295T, 299I, 303M
CDD
cd08963 (L-asparaginase_I)

20P

homodimer interface
13T, 20P, 21L, 22Q, 49N, 52D, 53S, 54S, 55D, 56M, 57N, 58P, 60I, 61W, 85D, 86T, 89Y, 111Q, 112V, 156K, 157I, 158D, 159A, 160T, 161N, 204D, 205I, 206I, 207V, 208L, 209E, 210I, 211F, 212P, 213G, 214M, 216I, 217E, 220N, 223L, 224N, 233K, 235F, 236G, 237N, 241P, 265Q, 268R, 269G, 270S, 271V, 272E, 276Y, 295T, 299I, 303M
CDD
cd08963 (L-asparaginase_I)

21L

homodimer interface
13T, 20P, 21L, 22Q, 49N, 52D, 53S, 54S, 55D, 56M, 57N, 58P, 60I, 61W, 85D, 86T, 89Y, 111Q, 112V, 156K, 157I, 158D, 159A, 160T, 161N, 204D, 205I, 206I, 207V, 208L, 209E, 210I, 211F, 212P, 213G, 214M, 216I, 217E, 220N, 223L, 224N, 233K, 235F, 236G, 237N, 241P, 265Q, 268R, 269G, 270S, 271V, 272E, 276Y, 295T, 299I, 303M
CDD
cd08963 (L-asparaginase_I)

22Q

homodimer interface
13T, 20P, 21L, 22Q, 49N, 52D, 53S, 54S, 55D, 56M, 57N, 58P, 60I, 61W, 85D, 86T, 89Y, 111Q, 112V, 156K, 157I, 158D, 159A, 160T, 161N, 204D, 205I, 206I, 207V, 208L, 209E, 210I, 211F, 212P, 213G, 214M, 216I, 217E, 220N, 223L, 224N, 233K, 235F, 236G, 237N, 241P, 265Q, 268R, 269G, 270S, 271V, 272E, 276Y, 295T, 299I, 303M
CDD
cd08963 (L-asparaginase_I)

49N

homodimer interface
13T, 20P, 21L, 22Q, 49N, 52D, 53S, 54S, 55D, 56M, 57N, 58P, 60I, 61W, 85D, 86T, 89Y, 111Q, 112V, 156K, 157I, 158D, 159A, 160T, 161N, 204D, 205I, 206I, 207V, 208L, 209E, 210I, 211F, 212P, 213G, 214M, 216I, 217E, 220N, 223L, 224N, 233K, 235F, 236G, 237N, 241P, 265Q, 268R, 269G, 270S, 271V, 272E, 276Y, 295T, 299I, 303M
CDD
cd08963 (L-asparaginase_I)

52D

homodimer interface
13T, 20P, 21L, 22Q, 49N, 52D, 53S, 54S, 55D, 56M, 57N, 58P, 60I, 61W, 85D, 86T, 89Y, 111Q, 112V, 156K, 157I, 158D, 159A, 160T, 161N, 204D, 205I, 206I, 207V, 208L, 209E, 210I, 211F, 212P, 213G, 214M, 216I, 217E, 220N, 223L, 224N, 233K, 235F, 236G, 237N, 241P, 265Q, 268R, 269G, 270S, 271V, 272E, 276Y, 295T, 299I, 303M
CDD
cd08963 (L-asparaginase_I)

53S

homodimer interface
13T, 20P, 21L, 22Q, 49N, 52D, 53S, 54S, 55D, 56M, 57N, 58P, 60I, 61W, 85D, 86T, 89Y, 111Q, 112V, 156K, 157I, 158D, 159A, 160T, 161N, 204D, 205I, 206I, 207V, 208L, 209E, 210I, 211F, 212P, 213G, 214M, 216I, 217E, 220N, 223L, 224N, 233K, 235F, 236G, 237N, 241P, 265Q, 268R, 269G, 270S, 271V, 272E, 276Y, 295T, 299I, 303M
CDD
cd08963 (L-asparaginase_I)

54S

homodimer interface
13T, 20P, 21L, 22Q, 49N, 52D, 53S, 54S, 55D, 56M, 57N, 58P, 60I, 61W, 85D, 86T, 89Y, 111Q, 112V, 156K, 157I, 158D, 159A, 160T, 161N, 204D, 205I, 206I, 207V, 208L, 209E, 210I, 211F, 212P, 213G, 214M, 216I, 217E, 220N, 223L, 224N, 233K, 235F, 236G, 237N, 241P, 265Q, 268R, 269G, 270S, 271V, 272E, 276Y, 295T, 299I, 303M
CDD
cd08963 (L-asparaginase_I)

55D

homodimer interface
13T, 20P, 21L, 22Q, 49N, 52D, 53S, 54S, 55D, 56M, 57N, 58P, 60I, 61W, 85D, 86T, 89Y, 111Q, 112V, 156K, 157I, 158D, 159A, 160T, 161N, 204D, 205I, 206I, 207V, 208L, 209E, 210I, 211F, 212P, 213G, 214M, 216I, 217E, 220N, 223L, 224N, 233K, 235F, 236G, 237N, 241P, 265Q, 268R, 269G, 270S, 271V, 272E, 276Y, 295T, 299I, 303M
CDD
cd08963 (L-asparaginase_I)

56M

homodimer interface
13T, 20P, 21L, 22Q, 49N, 52D, 53S, 54S, 55D, 56M, 57N, 58P, 60I, 61W, 85D, 86T, 89Y, 111Q, 112V, 156K, 157I, 158D, 159A, 160T, 161N, 204D, 205I, 206I, 207V, 208L, 209E, 210I, 211F, 212P, 213G, 214M, 216I, 217E, 220N, 223L, 224N, 233K, 235F, 236G, 237N, 241P, 265Q, 268R, 269G, 270S, 271V, 272E, 276Y, 295T, 299I, 303M
CDD
cd08963 (L-asparaginase_I)

57N

homodimer interface
13T, 20P, 21L, 22Q, 49N, 52D, 53S, 54S, 55D, 56M, 57N, 58P, 60I, 61W, 85D, 86T, 89Y, 111Q, 112V, 156K, 157I, 158D, 159A, 160T, 161N, 204D, 205I, 206I, 207V, 208L, 209E, 210I, 211F, 212P, 213G, 214M, 216I, 217E, 220N, 223L, 224N, 233K, 235F, 236G, 237N, 241P, 265Q, 268R, 269G, 270S, 271V, 272E, 276Y, 295T, 299I, 303M
CDD
cd08963 (L-asparaginase_I)

58P

homodimer interface
13T, 20P, 21L, 22Q, 49N, 52D, 53S, 54S, 55D, 56M, 57N, 58P, 60I, 61W, 85D, 86T, 89Y, 111Q, 112V, 156K, 157I, 158D, 159A, 160T, 161N, 204D, 205I, 206I, 207V, 208L, 209E, 210I, 211F, 212P, 213G, 214M, 216I, 217E, 220N, 223L, 224N, 233K, 235F, 236G, 237N, 241P, 265Q, 268R, 269G, 270S, 271V, 272E, 276Y, 295T, 299I, 303M
CDD
cd08963 (L-asparaginase_I)

60I

homodimer interface
13T, 20P, 21L, 22Q, 49N, 52D, 53S, 54S, 55D, 56M, 57N, 58P, 60I, 61W, 85D, 86T, 89Y, 111Q, 112V, 156K, 157I, 158D, 159A, 160T, 161N, 204D, 205I, 206I, 207V, 208L, 209E, 210I, 211F, 212P, 213G, 214M, 216I, 217E, 220N, 223L, 224N, 233K, 235F, 236G, 237N, 241P, 265Q, 268R, 269G, 270S, 271V, 272E, 276Y, 295T, 299I, 303M
CDD
cd08963 (L-asparaginase_I)

61W

homodimer interface
13T, 20P, 21L, 22Q, 49N, 52D, 53S, 54S, 55D, 56M, 57N, 58P, 60I, 61W, 85D, 86T, 89Y, 111Q, 112V, 156K, 157I, 158D, 159A, 160T, 161N, 204D, 205I, 206I, 207V, 208L, 209E, 210I, 211F, 212P, 213G, 214M, 216I, 217E, 220N, 223L, 224N, 233K, 235F, 236G, 237N, 241P, 265Q, 268R, 269G, 270S, 271V, 272E, 276Y, 295T, 299I, 303M
CDD
cd08963 (L-asparaginase_I)

85D

homodimer interface
13T, 20P, 21L, 22Q, 49N, 52D, 53S, 54S, 55D, 56M, 57N, 58P, 60I, 61W, 85D, 86T, 89Y, 111Q, 112V, 156K, 157I, 158D, 159A, 160T, 161N, 204D, 205I, 206I, 207V, 208L, 209E, 210I, 211F, 212P, 213G, 214M, 216I, 217E, 220N, 223L, 224N, 233K, 235F, 236G, 237N, 241P, 265Q, 268R, 269G, 270S, 271V, 272E, 276Y, 295T, 299I, 303M
CDD
cd08963 (L-asparaginase_I)

86T

homodimer interface
13T, 20P, 21L, 22Q, 49N, 52D, 53S, 54S, 55D, 56M, 57N, 58P, 60I, 61W, 85D, 86T, 89Y, 111Q, 112V, 156K, 157I, 158D, 159A, 160T, 161N, 204D, 205I, 206I, 207V, 208L, 209E, 210I, 211F, 212P, 213G, 214M, 216I, 217E, 220N, 223L, 224N, 233K, 235F, 236G, 237N, 241P, 265Q, 268R, 269G, 270S, 271V, 272E, 276Y, 295T, 299I, 303M
CDD
cd08963 (L-asparaginase_I)

89Y

homodimer interface
13T, 20P, 21L, 22Q, 49N, 52D, 53S, 54S, 55D, 56M, 57N, 58P, 60I, 61W, 85D, 86T, 89Y, 111Q, 112V, 156K, 157I, 158D, 159A, 160T, 161N, 204D, 205I, 206I, 207V, 208L, 209E, 210I, 211F, 212P, 213G, 214M, 216I, 217E, 220N, 223L, 224N, 233K, 235F, 236G, 237N, 241P, 265Q, 268R, 269G, 270S, 271V, 272E, 276Y, 295T, 299I, 303M
CDD
cd08963 (L-asparaginase_I)

111Q

homodimer interface
13T, 20P, 21L, 22Q, 49N, 52D, 53S, 54S, 55D, 56M, 57N, 58P, 60I, 61W, 85D, 86T, 89Y, 111Q, 112V, 156K, 157I, 158D, 159A, 160T, 161N, 204D, 205I, 206I, 207V, 208L, 209E, 210I, 211F, 212P, 213G, 214M, 216I, 217E, 220N, 223L, 224N, 233K, 235F, 236G, 237N, 241P, 265Q, 268R, 269G, 270S, 271V, 272E, 276Y, 295T, 299I, 303M
CDD
cd08963 (L-asparaginase_I)

112V

homodimer interface
13T, 20P, 21L, 22Q, 49N, 52D, 53S, 54S, 55D, 56M, 57N, 58P, 60I, 61W, 85D, 86T, 89Y, 111Q, 112V, 156K, 157I, 158D, 159A, 160T, 161N, 204D, 205I, 206I, 207V, 208L, 209E, 210I, 211F, 212P, 213G, 214M, 216I, 217E, 220N, 223L, 224N, 233K, 235F, 236G, 237N, 241P, 265Q, 268R, 269G, 270S, 271V, 272E, 276Y, 295T, 299I, 303M
CDD
cd08963 (L-asparaginase_I)

156K

homodimer interface
13T, 20P, 21L, 22Q, 49N, 52D, 53S, 54S, 55D, 56M, 57N, 58P, 60I, 61W, 85D, 86T, 89Y, 111Q, 112V, 156K, 157I, 158D, 159A, 160T, 161N, 204D, 205I, 206I, 207V, 208L, 209E, 210I, 211F, 212P, 213G, 214M, 216I, 217E, 220N, 223L, 224N, 233K, 235F, 236G, 237N, 241P, 265Q, 268R, 269G, 270S, 271V, 272E, 276Y, 295T, 299I, 303M
CDD
cd08963 (L-asparaginase_I)

157I

homodimer interface
13T, 20P, 21L, 22Q, 49N, 52D, 53S, 54S, 55D, 56M, 57N, 58P, 60I, 61W, 85D, 86T, 89Y, 111Q, 112V, 156K, 157I, 158D, 159A, 160T, 161N, 204D, 205I, 206I, 207V, 208L, 209E, 210I, 211F, 212P, 213G, 214M, 216I, 217E, 220N, 223L, 224N, 233K, 235F, 236G, 237N, 241P, 265Q, 268R, 269G, 270S, 271V, 272E, 276Y, 295T, 299I, 303M
CDD
cd08963 (L-asparaginase_I)

158D

homodimer interface
13T, 20P, 21L, 22Q, 49N, 52D, 53S, 54S, 55D, 56M, 57N, 58P, 60I, 61W, 85D, 86T, 89Y, 111Q, 112V, 156K, 157I, 158D, 159A, 160T, 161N, 204D, 205I, 206I, 207V, 208L, 209E, 210I, 211F, 212P, 213G, 214M, 216I, 217E, 220N, 223L, 224N, 233K, 235F, 236G, 237N, 241P, 265Q, 268R, 269G, 270S, 271V, 272E, 276Y, 295T, 299I, 303M
CDD
cd08963 (L-asparaginase_I)

159A

homodimer interface
13T, 20P, 21L, 22Q, 49N, 52D, 53S, 54S, 55D, 56M, 57N, 58P, 60I, 61W, 85D, 86T, 89Y, 111Q, 112V, 156K, 157I, 158D, 159A, 160T, 161N, 204D, 205I, 206I, 207V, 208L, 209E, 210I, 211F, 212P, 213G, 214M, 216I, 217E, 220N, 223L, 224N, 233K, 235F, 236G, 237N, 241P, 265Q, 268R, 269G, 270S, 271V, 272E, 276Y, 295T, 299I, 303M
CDD
cd08963 (L-asparaginase_I)

160T

homodimer interface
13T, 20P, 21L, 22Q, 49N, 52D, 53S, 54S, 55D, 56M, 57N, 58P, 60I, 61W, 85D, 86T, 89Y, 111Q, 112V, 156K, 157I, 158D, 159A, 160T, 161N, 204D, 205I, 206I, 207V, 208L, 209E, 210I, 211F, 212P, 213G, 214M, 216I, 217E, 220N, 223L, 224N, 233K, 235F, 236G, 237N, 241P, 265Q, 268R, 269G, 270S, 271V, 272E, 276Y, 295T, 299I, 303M
CDD
cd08963 (L-asparaginase_I)

161N

homodimer interface
13T, 20P, 21L, 22Q, 49N, 52D, 53S, 54S, 55D, 56M, 57N, 58P, 60I, 61W, 85D, 86T, 89Y, 111Q, 112V, 156K, 157I, 158D, 159A, 160T, 161N, 204D, 205I, 206I, 207V, 208L, 209E, 210I, 211F, 212P, 213G, 214M, 216I, 217E, 220N, 223L, 224N, 233K, 235F, 236G, 237N, 241P, 265Q, 268R, 269G, 270S, 271V, 272E, 276Y, 295T, 299I, 303M
CDD
cd08963 (L-asparaginase_I)

204D

homodimer interface
13T, 20P, 21L, 22Q, 49N, 52D, 53S, 54S, 55D, 56M, 57N, 58P, 60I, 61W, 85D, 86T, 89Y, 111Q, 112V, 156K, 157I, 158D, 159A, 160T, 161N, 204D, 205I, 206I, 207V, 208L, 209E, 210I, 211F, 212P, 213G, 214M, 216I, 217E, 220N, 223L, 224N, 233K, 235F, 236G, 237N, 241P, 265Q, 268R, 269G, 270S, 271V, 272E, 276Y, 295T, 299I, 303M
CDD
cd08963 (L-asparaginase_I)

205I

homodimer interface
13T, 20P, 21L, 22Q, 49N, 52D, 53S, 54S, 55D, 56M, 57N, 58P, 60I, 61W, 85D, 86T, 89Y, 111Q, 112V, 156K, 157I, 158D, 159A, 160T, 161N, 204D, 205I, 206I, 207V, 208L, 209E, 210I, 211F, 212P, 213G, 214M, 216I, 217E, 220N, 223L, 224N, 233K, 235F, 236G, 237N, 241P, 265Q, 268R, 269G, 270S, 271V, 272E, 276Y, 295T, 299I, 303M
CDD
cd08963 (L-asparaginase_I)

206I

homodimer interface
13T, 20P, 21L, 22Q, 49N, 52D, 53S, 54S, 55D, 56M, 57N, 58P, 60I, 61W, 85D, 86T, 89Y, 111Q, 112V, 156K, 157I, 158D, 159A, 160T, 161N, 204D, 205I, 206I, 207V, 208L, 209E, 210I, 211F, 212P, 213G, 214M, 216I, 217E, 220N, 223L, 224N, 233K, 235F, 236G, 237N, 241P, 265Q, 268R, 269G, 270S, 271V, 272E, 276Y, 295T, 299I, 303M
CDD
cd08963 (L-asparaginase_I)

207V

homodimer interface
13T, 20P, 21L, 22Q, 49N, 52D, 53S, 54S, 55D, 56M, 57N, 58P, 60I, 61W, 85D, 86T, 89Y, 111Q, 112V, 156K, 157I, 158D, 159A, 160T, 161N, 204D, 205I, 206I, 207V, 208L, 209E, 210I, 211F, 212P, 213G, 214M, 216I, 217E, 220N, 223L, 224N, 233K, 235F, 236G, 237N, 241P, 265Q, 268R, 269G, 270S, 271V, 272E, 276Y, 295T, 299I, 303M
CDD
cd08963 (L-asparaginase_I)

208L

homodimer interface
13T, 20P, 21L, 22Q, 49N, 52D, 53S, 54S, 55D, 56M, 57N, 58P, 60I, 61W, 85D, 86T, 89Y, 111Q, 112V, 156K, 157I, 158D, 159A, 160T, 161N, 204D, 205I, 206I, 207V, 208L, 209E, 210I, 211F, 212P, 213G, 214M, 216I, 217E, 220N, 223L, 224N, 233K, 235F, 236G, 237N, 241P, 265Q, 268R, 269G, 270S, 271V, 272E, 276Y, 295T, 299I, 303M
CDD
cd08963 (L-asparaginase_I)

209E

homodimer interface
13T, 20P, 21L, 22Q, 49N, 52D, 53S, 54S, 55D, 56M, 57N, 58P, 60I, 61W, 85D, 86T, 89Y, 111Q, 112V, 156K, 157I, 158D, 159A, 160T, 161N, 204D, 205I, 206I, 207V, 208L, 209E, 210I, 211F, 212P, 213G, 214M, 216I, 217E, 220N, 223L, 224N, 233K, 235F, 236G, 237N, 241P, 265Q, 268R, 269G, 270S, 271V, 272E, 276Y, 295T, 299I, 303M
CDD
cd08963 (L-asparaginase_I)

210I

homodimer interface
13T, 20P, 21L, 22Q, 49N, 52D, 53S, 54S, 55D, 56M, 57N, 58P, 60I, 61W, 85D, 86T, 89Y, 111Q, 112V, 156K, 157I, 158D, 159A, 160T, 161N, 204D, 205I, 206I, 207V, 208L, 209E, 210I, 211F, 212P, 213G, 214M, 216I, 217E, 220N, 223L, 224N, 233K, 235F, 236G, 237N, 241P, 265Q, 268R, 269G, 270S, 271V, 272E, 276Y, 295T, 299I, 303M
CDD
cd08963 (L-asparaginase_I)

211F

homodimer interface
13T, 20P, 21L, 22Q, 49N, 52D, 53S, 54S, 55D, 56M, 57N, 58P, 60I, 61W, 85D, 86T, 89Y, 111Q, 112V, 156K, 157I, 158D, 159A, 160T, 161N, 204D, 205I, 206I, 207V, 208L, 209E, 210I, 211F, 212P, 213G, 214M, 216I, 217E, 220N, 223L, 224N, 233K, 235F, 236G, 237N, 241P, 265Q, 268R, 269G, 270S, 271V, 272E, 276Y, 295T, 299I, 303M
CDD
cd08963 (L-asparaginase_I)

212P

homodimer interface
13T, 20P, 21L, 22Q, 49N, 52D, 53S, 54S, 55D, 56M, 57N, 58P, 60I, 61W, 85D, 86T, 89Y, 111Q, 112V, 156K, 157I, 158D, 159A, 160T, 161N, 204D, 205I, 206I, 207V, 208L, 209E, 210I, 211F, 212P, 213G, 214M, 216I, 217E, 220N, 223L, 224N, 233K, 235F, 236G, 237N, 241P, 265Q, 268R, 269G, 270S, 271V, 272E, 276Y, 295T, 299I, 303M
CDD
cd08963 (L-asparaginase_I)

213G

homodimer interface
13T, 20P, 21L, 22Q, 49N, 52D, 53S, 54S, 55D, 56M, 57N, 58P, 60I, 61W, 85D, 86T, 89Y, 111Q, 112V, 156K, 157I, 158D, 159A, 160T, 161N, 204D, 205I, 206I, 207V, 208L, 209E, 210I, 211F, 212P, 213G, 214M, 216I, 217E, 220N, 223L, 224N, 233K, 235F, 236G, 237N, 241P, 265Q, 268R, 269G, 270S, 271V, 272E, 276Y, 295T, 299I, 303M
CDD
cd08963 (L-asparaginase_I)

214M

homodimer interface
13T, 20P, 21L, 22Q, 49N, 52D, 53S, 54S, 55D, 56M, 57N, 58P, 60I, 61W, 85D, 86T, 89Y, 111Q, 112V, 156K, 157I, 158D, 159A, 160T, 161N, 204D, 205I, 206I, 207V, 208L, 209E, 210I, 211F, 212P, 213G, 214M, 216I, 217E, 220N, 223L, 224N, 233K, 235F, 236G, 237N, 241P, 265Q, 268R, 269G, 270S, 271V, 272E, 276Y, 295T, 299I, 303M
CDD
cd08963 (L-asparaginase_I)

216I

homodimer interface
13T, 20P, 21L, 22Q, 49N, 52D, 53S, 54S, 55D, 56M, 57N, 58P, 60I, 61W, 85D, 86T, 89Y, 111Q, 112V, 156K, 157I, 158D, 159A, 160T, 161N, 204D, 205I, 206I, 207V, 208L, 209E, 210I, 211F, 212P, 213G, 214M, 216I, 217E, 220N, 223L, 224N, 233K, 235F, 236G, 237N, 241P, 265Q, 268R, 269G, 270S, 271V, 272E, 276Y, 295T, 299I, 303M
CDD
cd08963 (L-asparaginase_I)

217E

homodimer interface
13T, 20P, 21L, 22Q, 49N, 52D, 53S, 54S, 55D, 56M, 57N, 58P, 60I, 61W, 85D, 86T, 89Y, 111Q, 112V, 156K, 157I, 158D, 159A, 160T, 161N, 204D, 205I, 206I, 207V, 208L, 209E, 210I, 211F, 212P, 213G, 214M, 216I, 217E, 220N, 223L, 224N, 233K, 235F, 236G, 237N, 241P, 265Q, 268R, 269G, 270S, 271V, 272E, 276Y, 295T, 299I, 303M
CDD
cd08963 (L-asparaginase_I)

220N

homodimer interface
13T, 20P, 21L, 22Q, 49N, 52D, 53S, 54S, 55D, 56M, 57N, 58P, 60I, 61W, 85D, 86T, 89Y, 111Q, 112V, 156K, 157I, 158D, 159A, 160T, 161N, 204D, 205I, 206I, 207V, 208L, 209E, 210I, 211F, 212P, 213G, 214M, 216I, 217E, 220N, 223L, 224N, 233K, 235F, 236G, 237N, 241P, 265Q, 268R, 269G, 270S, 271V, 272E, 276Y, 295T, 299I, 303M
CDD
cd08963 (L-asparaginase_I)

223L

homodimer interface
13T, 20P, 21L, 22Q, 49N, 52D, 53S, 54S, 55D, 56M, 57N, 58P, 60I, 61W, 85D, 86T, 89Y, 111Q, 112V, 156K, 157I, 158D, 159A, 160T, 161N, 204D, 205I, 206I, 207V, 208L, 209E, 210I, 211F, 212P, 213G, 214M, 216I, 217E, 220N, 223L, 224N, 233K, 235F, 236G, 237N, 241P, 265Q, 268R, 269G, 270S, 271V, 272E, 276Y, 295T, 299I, 303M
CDD
cd08963 (L-asparaginase_I)

224N

homodimer interface
13T, 20P, 21L, 22Q, 49N, 52D, 53S, 54S, 55D, 56M, 57N, 58P, 60I, 61W, 85D, 86T, 89Y, 111Q, 112V, 156K, 157I, 158D, 159A, 160T, 161N, 204D, 205I, 206I, 207V, 208L, 209E, 210I, 211F, 212P, 213G, 214M, 216I, 217E, 220N, 223L, 224N, 233K, 235F, 236G, 237N, 241P, 265Q, 268R, 269G, 270S, 271V, 272E, 276Y, 295T, 299I, 303M
CDD
cd08963 (L-asparaginase_I)

233K

homodimer interface
13T, 20P, 21L, 22Q, 49N, 52D, 53S, 54S, 55D, 56M, 57N, 58P, 60I, 61W, 85D, 86T, 89Y, 111Q, 112V, 156K, 157I, 158D, 159A, 160T, 161N, 204D, 205I, 206I, 207V, 208L, 209E, 210I, 211F, 212P, 213G, 214M, 216I, 217E, 220N, 223L, 224N, 233K, 235F, 236G, 237N, 241P, 265Q, 268R, 269G, 270S, 271V, 272E, 276Y, 295T, 299I, 303M
CDD
cd08963 (L-asparaginase_I)

235F

homodimer interface
13T, 20P, 21L, 22Q, 49N, 52D, 53S, 54S, 55D, 56M, 57N, 58P, 60I, 61W, 85D, 86T, 89Y, 111Q, 112V, 156K, 157I, 158D, 159A, 160T, 161N, 204D, 205I, 206I, 207V, 208L, 209E, 210I, 211F, 212P, 213G, 214M, 216I, 217E, 220N, 223L, 224N, 233K, 235F, 236G, 237N, 241P, 265Q, 268R, 269G, 270S, 271V, 272E, 276Y, 295T, 299I, 303M
CDD
cd08963 (L-asparaginase_I)

236G

homodimer interface
13T, 20P, 21L, 22Q, 49N, 52D, 53S, 54S, 55D, 56M, 57N, 58P, 60I, 61W, 85D, 86T, 89Y, 111Q, 112V, 156K, 157I, 158D, 159A, 160T, 161N, 204D, 205I, 206I, 207V, 208L, 209E, 210I, 211F, 212P, 213G, 214M, 216I, 217E, 220N, 223L, 224N, 233K, 235F, 236G, 237N, 241P, 265Q, 268R, 269G, 270S, 271V, 272E, 276Y, 295T, 299I, 303M
CDD
cd08963 (L-asparaginase_I)

237N

homodimer interface
13T, 20P, 21L, 22Q, 49N, 52D, 53S, 54S, 55D, 56M, 57N, 58P, 60I, 61W, 85D, 86T, 89Y, 111Q, 112V, 156K, 157I, 158D, 159A, 160T, 161N, 204D, 205I, 206I, 207V, 208L, 209E, 210I, 211F, 212P, 213G, 214M, 216I, 217E, 220N, 223L, 224N, 233K, 235F, 236G, 237N, 241P, 265Q, 268R, 269G, 270S, 271V, 272E, 276Y, 295T, 299I, 303M
CDD
cd08963 (L-asparaginase_I)

241P

homodimer interface
13T, 20P, 21L, 22Q, 49N, 52D, 53S, 54S, 55D, 56M, 57N, 58P, 60I, 61W, 85D, 86T, 89Y, 111Q, 112V, 156K, 157I, 158D, 159A, 160T, 161N, 204D, 205I, 206I, 207V, 208L, 209E, 210I, 211F, 212P, 213G, 214M, 216I, 217E, 220N, 223L, 224N, 233K, 235F, 236G, 237N, 241P, 265Q, 268R, 269G, 270S, 271V, 272E, 276Y, 295T, 299I, 303M
CDD
cd08963 (L-asparaginase_I)

265Q

homodimer interface
13T, 20P, 21L, 22Q, 49N, 52D, 53S, 54S, 55D, 56M, 57N, 58P, 60I, 61W, 85D, 86T, 89Y, 111Q, 112V, 156K, 157I, 158D, 159A, 160T, 161N, 204D, 205I, 206I, 207V, 208L, 209E, 210I, 211F, 212P, 213G, 214M, 216I, 217E, 220N, 223L, 224N, 233K, 235F, 236G, 237N, 241P, 265Q, 268R, 269G, 270S, 271V, 272E, 276Y, 295T, 299I, 303M
CDD
cd08963 (L-asparaginase_I)

268R

homodimer interface
13T, 20P, 21L, 22Q, 49N, 52D, 53S, 54S, 55D, 56M, 57N, 58P, 60I, 61W, 85D, 86T, 89Y, 111Q, 112V, 156K, 157I, 158D, 159A, 160T, 161N, 204D, 205I, 206I, 207V, 208L, 209E, 210I, 211F, 212P, 213G, 214M, 216I, 217E, 220N, 223L, 224N, 233K, 235F, 236G, 237N, 241P, 265Q, 268R, 269G, 270S, 271V, 272E, 276Y, 295T, 299I, 303M
CDD
cd08963 (L-asparaginase_I)

269G

homodimer interface
13T, 20P, 21L, 22Q, 49N, 52D, 53S, 54S, 55D, 56M, 57N, 58P, 60I, 61W, 85D, 86T, 89Y, 111Q, 112V, 156K, 157I, 158D, 159A, 160T, 161N, 204D, 205I, 206I, 207V, 208L, 209E, 210I, 211F, 212P, 213G, 214M, 216I, 217E, 220N, 223L, 224N, 233K, 235F, 236G, 237N, 241P, 265Q, 268R, 269G, 270S, 271V, 272E, 276Y, 295T, 299I, 303M
CDD
cd08963 (L-asparaginase_I)

270S

homodimer interface
13T, 20P, 21L, 22Q, 49N, 52D, 53S, 54S, 55D, 56M, 57N, 58P, 60I, 61W, 85D, 86T, 89Y, 111Q, 112V, 156K, 157I, 158D, 159A, 160T, 161N, 204D, 205I, 206I, 207V, 208L, 209E, 210I, 211F, 212P, 213G, 214M, 216I, 217E, 220N, 223L, 224N, 233K, 235F, 236G, 237N, 241P, 265Q, 268R, 269G, 270S, 271V, 272E, 276Y, 295T, 299I, 303M
CDD
cd08963 (L-asparaginase_I)

271V

homodimer interface
13T, 20P, 21L, 22Q, 49N, 52D, 53S, 54S, 55D, 56M, 57N, 58P, 60I, 61W, 85D, 86T, 89Y, 111Q, 112V, 156K, 157I, 158D, 159A, 160T, 161N, 204D, 205I, 206I, 207V, 208L, 209E, 210I, 211F, 212P, 213G, 214M, 216I, 217E, 220N, 223L, 224N, 233K, 235F, 236G, 237N, 241P, 265Q, 268R, 269G, 270S, 271V, 272E, 276Y, 295T, 299I, 303M
CDD
cd08963 (L-asparaginase_I)

272E

homodimer interface
13T, 20P, 21L, 22Q, 49N, 52D, 53S, 54S, 55D, 56M, 57N, 58P, 60I, 61W, 85D, 86T, 89Y, 111Q, 112V, 156K, 157I, 158D, 159A, 160T, 161N, 204D, 205I, 206I, 207V, 208L, 209E, 210I, 211F, 212P, 213G, 214M, 216I, 217E, 220N, 223L, 224N, 233K, 235F, 236G, 237N, 241P, 265Q, 268R, 269G, 270S, 271V, 272E, 276Y, 295T, 299I, 303M
CDD
cd08963 (L-asparaginase_I)

276Y

homodimer interface
13T, 20P, 21L, 22Q, 49N, 52D, 53S, 54S, 55D, 56M, 57N, 58P, 60I, 61W, 85D, 86T, 89Y, 111Q, 112V, 156K, 157I, 158D, 159A, 160T, 161N, 204D, 205I, 206I, 207V, 208L, 209E, 210I, 211F, 212P, 213G, 214M, 216I, 217E, 220N, 223L, 224N, 233K, 235F, 236G, 237N, 241P, 265Q, 268R, 269G, 270S, 271V, 272E, 276Y, 295T, 299I, 303M
CDD
cd08963 (L-asparaginase_I)

295T

homodimer interface
13T, 20P, 21L, 22Q, 49N, 52D, 53S, 54S, 55D, 56M, 57N, 58P, 60I, 61W, 85D, 86T, 89Y, 111Q, 112V, 156K, 157I, 158D, 159A, 160T, 161N, 204D, 205I, 206I, 207V, 208L, 209E, 210I, 211F, 212P, 213G, 214M, 216I, 217E, 220N, 223L, 224N, 233K, 235F, 236G, 237N, 241P, 265Q, 268R, 269G, 270S, 271V, 272E, 276Y, 295T, 299I, 303M
CDD
cd08963 (L-asparaginase_I)

299I

homodimer interface
13T, 20P, 21L, 22Q, 49N, 52D, 53S, 54S, 55D, 56M, 57N, 58P, 60I, 61W, 85D, 86T, 89Y, 111Q, 112V, 156K, 157I, 158D, 159A, 160T, 161N, 204D, 205I, 206I, 207V, 208L, 209E, 210I, 211F, 212P, 213G, 214M, 216I, 217E, 220N, 223L, 224N, 233K, 235F, 236G, 237N, 241P, 265Q, 268R, 269G, 270S, 271V, 272E, 276Y, 295T, 299I, 303M
CDD
cd08963 (L-asparaginase_I)

303M

homodimer interface
13T, 20P, 21L, 22Q, 49N, 52D, 53S, 54S, 55D, 56M, 57N, 58P, 60I, 61W, 85D, 86T, 89Y, 111Q, 112V, 156K, 157I, 158D, 159A, 160T, 161N, 204D, 205I, 206I, 207V, 208L, 209E, 210I, 211F, 212P, 213G, 214M, 216I, 217E, 220N, 223L, 224N, 233K, 235F, 236G, 237N, 241P, 265Q, 268R, 269G, 270S, 271V, 272E, 276Y, 295T, 299I, 303M
CDD
cd08963 (L-asparaginase_I)

GO term prediction

Biological Process

GO:0006520 cellular amino acid metabolic process

Molecular Function

GO:0004067 asparaginase activity

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features

25563_FusoPortal_Gene_1125

Protein family membership

Homologous superfamilies

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component