25563_FusoPortal_Gene_1203

Protein

25563_FusoPortal_Gene_1203

Length

348 amino acids

Protein family membership

Enoyl-CoA hydratase/isomerase, HIBYL-CoA-H type (IPR032259)

Homologous superfamilies

Homologous superfamily
3 - 195
ClpP/crotonase-like domain superfamily (IPR029045)
261 - 330
ClpP/crotonase-like domain superfamily (IPR029045)

1 50 100 150 200 250 300 348

Domains and repeats

None predicted.

Detailed signature matches

IPR029045

ClpP/crotonase-like domain superfamily
1. SSF52096 (ClpP/crot...)
  
  261 - 330
  
  SUPERFAMILY
  SSF52096 (ClpP/crotonase)
  
  3 - 195
  
  SUPERFAMILY
  SSF52096 (ClpP/crotonase)
IPR032259

Enoyl-CoA hydratase/isomerase, HIBYL-CoA-H type
1. PF16113 (ECH_2)
  
  14 - 347
  
  Pfam
  PF16113 (ECH_2)

no IPR

Unintegrated signatures

G3DSA:3.90.22...

1 - 341

GENE3D
G3DSA:3.90.226.10 (G3DSA:3.90.226.10)
PTHR43176 (FAMILY N...)

4 - 347

PANTHER
PTHR43176 (FAMILY NOT NAMED)
PTHR43176:SF3 (3-HY...)

4 - 347

PANTHER
PTHR43176:SF3 (3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL)
cd06558 (crotonase-...)

5 - 183

CDD
cd06558 (crotonase-like)

Residue annotation

substrate binding ...

24L

substrate binding site
24L, 26A, 59K, 63A, 64G, 65G, 66D, 67L, 110I, 112M, 113G, 114G, 136P, 137E, 140I
CDD
cd06558 (crotonase-like)

26A

substrate binding site
24L, 26A, 59K, 63A, 64G, 65G, 66D, 67L, 110I, 112M, 113G, 114G, 136P, 137E, 140I
CDD
cd06558 (crotonase-like)

59K

substrate binding site
24L, 26A, 59K, 63A, 64G, 65G, 66D, 67L, 110I, 112M, 113G, 114G, 136P, 137E, 140I
CDD
cd06558 (crotonase-like)

63A

substrate binding site
24L, 26A, 59K, 63A, 64G, 65G, 66D, 67L, 110I, 112M, 113G, 114G, 136P, 137E, 140I
CDD
cd06558 (crotonase-like)

64G

substrate binding site
24L, 26A, 59K, 63A, 64G, 65G, 66D, 67L, 110I, 112M, 113G, 114G, 136P, 137E, 140I
CDD
cd06558 (crotonase-like)

65G

substrate binding site
24L, 26A, 59K, 63A, 64G, 65G, 66D, 67L, 110I, 112M, 113G, 114G, 136P, 137E, 140I
CDD
cd06558 (crotonase-like)

66D

substrate binding site
24L, 26A, 59K, 63A, 64G, 65G, 66D, 67L, 110I, 112M, 113G, 114G, 136P, 137E, 140I
CDD
cd06558 (crotonase-like)

67L

substrate binding site
24L, 26A, 59K, 63A, 64G, 65G, 66D, 67L, 110I, 112M, 113G, 114G, 136P, 137E, 140I
CDD
cd06558 (crotonase-like)

110I

substrate binding site
24L, 26A, 59K, 63A, 64G, 65G, 66D, 67L, 110I, 112M, 113G, 114G, 136P, 137E, 140I
CDD
cd06558 (crotonase-like)

112M

substrate binding site
24L, 26A, 59K, 63A, 64G, 65G, 66D, 67L, 110I, 112M, 113G, 114G, 136P, 137E, 140I
CDD
cd06558 (crotonase-like)

113G

substrate binding site
24L, 26A, 59K, 63A, 64G, 65G, 66D, 67L, 110I, 112M, 113G, 114G, 136P, 137E, 140I
CDD
cd06558 (crotonase-like)

114G

substrate binding site
24L, 26A, 59K, 63A, 64G, 65G, 66D, 67L, 110I, 112M, 113G, 114G, 136P, 137E, 140I
CDD
cd06558 (crotonase-like)

136P

substrate binding site
24L, 26A, 59K, 63A, 64G, 65G, 66D, 67L, 110I, 112M, 113G, 114G, 136P, 137E, 140I
CDD
cd06558 (crotonase-like)

137E

substrate binding site
24L, 26A, 59K, 63A, 64G, 65G, 66D, 67L, 110I, 112M, 113G, 114G, 136P, 137E, 140I
CDD
cd06558 (crotonase-like)

140I

substrate binding site
24L, 26A, 59K, 63A, 64G, 65G, 66D, 67L, 110I, 112M, 113G, 114G, 136P, 137E, 140I
CDD
cd06558 (crotonase-like)
oxyanion hole (OAH...

65G

oxyanion hole (OAH) forming residues
65G, 114G
CDD
cd06558 (crotonase-like)

114G

oxyanion hole (OAH) forming residues
65G, 114G
CDD
cd06558 (crotonase-like)
trimer interface c...

94S

trimer interface
94S, 102P, 123D, 124I, 125R, 126I, 138M, 139R, 140I, 141G, 147A, 149S, 150Y, 151Y, 153A, 154R, 158G, 159L, 161E, 162Y, 164A, 165I, 168N, 179G, 182D
CDD
cd06558 (crotonase-like)

102P

trimer interface
94S, 102P, 123D, 124I, 125R, 126I, 138M, 139R, 140I, 141G, 147A, 149S, 150Y, 151Y, 153A, 154R, 158G, 159L, 161E, 162Y, 164A, 165I, 168N, 179G, 182D
CDD
cd06558 (crotonase-like)

123D

trimer interface
94S, 102P, 123D, 124I, 125R, 126I, 138M, 139R, 140I, 141G, 147A, 149S, 150Y, 151Y, 153A, 154R, 158G, 159L, 161E, 162Y, 164A, 165I, 168N, 179G, 182D
CDD
cd06558 (crotonase-like)

124I

trimer interface
94S, 102P, 123D, 124I, 125R, 126I, 138M, 139R, 140I, 141G, 147A, 149S, 150Y, 151Y, 153A, 154R, 158G, 159L, 161E, 162Y, 164A, 165I, 168N, 179G, 182D
CDD
cd06558 (crotonase-like)

125R

trimer interface
94S, 102P, 123D, 124I, 125R, 126I, 138M, 139R, 140I, 141G, 147A, 149S, 150Y, 151Y, 153A, 154R, 158G, 159L, 161E, 162Y, 164A, 165I, 168N, 179G, 182D
CDD
cd06558 (crotonase-like)

126I

trimer interface
94S, 102P, 123D, 124I, 125R, 126I, 138M, 139R, 140I, 141G, 147A, 149S, 150Y, 151Y, 153A, 154R, 158G, 159L, 161E, 162Y, 164A, 165I, 168N, 179G, 182D
CDD
cd06558 (crotonase-like)

138M

trimer interface
94S, 102P, 123D, 124I, 125R, 126I, 138M, 139R, 140I, 141G, 147A, 149S, 150Y, 151Y, 153A, 154R, 158G, 159L, 161E, 162Y, 164A, 165I, 168N, 179G, 182D
CDD
cd06558 (crotonase-like)

139R

trimer interface
94S, 102P, 123D, 124I, 125R, 126I, 138M, 139R, 140I, 141G, 147A, 149S, 150Y, 151Y, 153A, 154R, 158G, 159L, 161E, 162Y, 164A, 165I, 168N, 179G, 182D
CDD
cd06558 (crotonase-like)

140I

trimer interface
94S, 102P, 123D, 124I, 125R, 126I, 138M, 139R, 140I, 141G, 147A, 149S, 150Y, 151Y, 153A, 154R, 158G, 159L, 161E, 162Y, 164A, 165I, 168N, 179G, 182D
CDD
cd06558 (crotonase-like)

141G

trimer interface
94S, 102P, 123D, 124I, 125R, 126I, 138M, 139R, 140I, 141G, 147A, 149S, 150Y, 151Y, 153A, 154R, 158G, 159L, 161E, 162Y, 164A, 165I, 168N, 179G, 182D
CDD
cd06558 (crotonase-like)

147A

trimer interface
94S, 102P, 123D, 124I, 125R, 126I, 138M, 139R, 140I, 141G, 147A, 149S, 150Y, 151Y, 153A, 154R, 158G, 159L, 161E, 162Y, 164A, 165I, 168N, 179G, 182D
CDD
cd06558 (crotonase-like)

149S

trimer interface
94S, 102P, 123D, 124I, 125R, 126I, 138M, 139R, 140I, 141G, 147A, 149S, 150Y, 151Y, 153A, 154R, 158G, 159L, 161E, 162Y, 164A, 165I, 168N, 179G, 182D
CDD
cd06558 (crotonase-like)

150Y

trimer interface
94S, 102P, 123D, 124I, 125R, 126I, 138M, 139R, 140I, 141G, 147A, 149S, 150Y, 151Y, 153A, 154R, 158G, 159L, 161E, 162Y, 164A, 165I, 168N, 179G, 182D
CDD
cd06558 (crotonase-like)

151Y

trimer interface
94S, 102P, 123D, 124I, 125R, 126I, 138M, 139R, 140I, 141G, 147A, 149S, 150Y, 151Y, 153A, 154R, 158G, 159L, 161E, 162Y, 164A, 165I, 168N, 179G, 182D
CDD
cd06558 (crotonase-like)

153A

trimer interface
94S, 102P, 123D, 124I, 125R, 126I, 138M, 139R, 140I, 141G, 147A, 149S, 150Y, 151Y, 153A, 154R, 158G, 159L, 161E, 162Y, 164A, 165I, 168N, 179G, 182D
CDD
cd06558 (crotonase-like)

154R

trimer interface
94S, 102P, 123D, 124I, 125R, 126I, 138M, 139R, 140I, 141G, 147A, 149S, 150Y, 151Y, 153A, 154R, 158G, 159L, 161E, 162Y, 164A, 165I, 168N, 179G, 182D
CDD
cd06558 (crotonase-like)

158G

trimer interface
94S, 102P, 123D, 124I, 125R, 126I, 138M, 139R, 140I, 141G, 147A, 149S, 150Y, 151Y, 153A, 154R, 158G, 159L, 161E, 162Y, 164A, 165I, 168N, 179G, 182D
CDD
cd06558 (crotonase-like)

159L

trimer interface
94S, 102P, 123D, 124I, 125R, 126I, 138M, 139R, 140I, 141G, 147A, 149S, 150Y, 151Y, 153A, 154R, 158G, 159L, 161E, 162Y, 164A, 165I, 168N, 179G, 182D
CDD
cd06558 (crotonase-like)

161E

trimer interface
94S, 102P, 123D, 124I, 125R, 126I, 138M, 139R, 140I, 141G, 147A, 149S, 150Y, 151Y, 153A, 154R, 158G, 159L, 161E, 162Y, 164A, 165I, 168N, 179G, 182D
CDD
cd06558 (crotonase-like)

162Y

trimer interface
94S, 102P, 123D, 124I, 125R, 126I, 138M, 139R, 140I, 141G, 147A, 149S, 150Y, 151Y, 153A, 154R, 158G, 159L, 161E, 162Y, 164A, 165I, 168N, 179G, 182D
CDD
cd06558 (crotonase-like)

164A

trimer interface
94S, 102P, 123D, 124I, 125R, 126I, 138M, 139R, 140I, 141G, 147A, 149S, 150Y, 151Y, 153A, 154R, 158G, 159L, 161E, 162Y, 164A, 165I, 168N, 179G, 182D
CDD
cd06558 (crotonase-like)

165I

trimer interface
94S, 102P, 123D, 124I, 125R, 126I, 138M, 139R, 140I, 141G, 147A, 149S, 150Y, 151Y, 153A, 154R, 158G, 159L, 161E, 162Y, 164A, 165I, 168N, 179G, 182D
CDD
cd06558 (crotonase-like)

168N

trimer interface
94S, 102P, 123D, 124I, 125R, 126I, 138M, 139R, 140I, 141G, 147A, 149S, 150Y, 151Y, 153A, 154R, 158G, 159L, 161E, 162Y, 164A, 165I, 168N, 179G, 182D
CDD
cd06558 (crotonase-like)

179G

trimer interface
94S, 102P, 123D, 124I, 125R, 126I, 138M, 139R, 140I, 141G, 147A, 149S, 150Y, 151Y, 153A, 154R, 158G, 159L, 161E, 162Y, 164A, 165I, 168N, 179G, 182D
CDD
cd06558 (crotonase-like)

182D

trimer interface
94S, 102P, 123D, 124I, 125R, 126I, 138M, 139R, 140I, 141G, 147A, 149S, 150Y, 151Y, 153A, 154R, 158G, 159L, 161E, 162Y, 164A, 165I, 168N, 179G, 182D
CDD
cd06558 (crotonase-like)

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0003860 3-hydroxyisobutyryl-CoA hydrolase activity

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features

25563_FusoPortal_Gene_1203

Protein family membership

Homologous superfamilies

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component