25563_FusoPortal_Gene_1378

Protein

25563_FusoPortal_Gene_1378

Length

435 amino acids

Protein family membership

Enolase-like superfamily (IPR034390)
- Enolase (IPR000941)

Homologous superfamilies

Homologous superfamily
3 - 138
Enolase-like, N-terminal (IPR029017)
Homologous superfamily
128 - 435
Enolase-like, C-terminal (IPR036849)

1 50 100 150 200 250 300 350 400 435

Domains and repeats

Domain
4 - 134
Enolase, N-terminal (IPR020811)
141 - 430
Enolase, C-terminal TIM barrel domain (IPR020810)

1 50 100 150 200 250 300 350 400 435

Detailed signature matches

IPR029017

Enolase-like, N-terminal
1. SSF54826 (Enolase N...)
  
  3 - 138
  
  SUPERFAMILY
  SSF54826 (Enolase N-terminal domain-like)
2. G3DSA:3.30.39...
  
  3 - 126
  
  GENE3D
  G3DSA:3.30.390.10 (G3DSA:3.30.390.10)
IPR036849

Enolase-like, C-terminal
1. G3DSA:3.20.20...
  
  128 - 435
  
  GENE3D
  G3DSA:3.20.20.120 (G3DSA:3.20.20.120)
2. SSF51604 (Enolase C...)
  
  139 - 432
  
  SUPERFAMILY
  SSF51604 (Enolase C-terminal domain-like)
IPR034390

Enolase-like superfamily
1. SFLDS00001 (Enolase)
  
  4 - 429
  
  SFLD
  SFLDS00001 (Enolase)
IPR000941

Enolase
1. PR00148 (ENOLASE)
  
  107 - 123
  
  PRINTS
  PR00148 (ENOLASE)
  
  340 - 354
  
  PRINTS
  PR00148 (ENOLASE)
  
  317 - 328
  
  PRINTS
  PR00148 (ENOLASE)
  
  37 - 51
  
  PRINTS
  PR00148 (ENOLASE)
  
  161 - 174
  
  PRINTS
  PR00148 (ENOLASE)
  
  369 - 386
  
  PRINTS
  PR00148 (ENOLASE)
2. PIRSF001400 (Enolase)
  
  1 - 431
  
  PIRSF
  PIRSF001400 (Enolase)
3. SFLDG00178 (enolase)
  
  2 - 417
  
  SFLD
  SFLDG00178 (enolase)
4. PTHR11902 (ENOLASE)
  
  1 - 425
  
  PANTHER
  PTHR11902 (ENOLASE)
5. cd03313 (enolase)
  
  6 - 416
  
  CDD
  cd03313 (enolase)
6. MF_00318 (Enolase)
  
  2 - 417
  
  HAMAP
  MF_00318 (Enolase)
7. TIGR01060
  
  4 - 431
  
  TIGRFAMs
  TIGR01060 (TIGR01060)
IPR020811

Enolase, N-terminal
1. PF03952 (Enolase_N)
  
  4 - 134
  
  Pfam
  PF03952 (Enolase_N)
IPR020810

Enolase, C-terminal TIM barrel domain
1. PF00113 (Enolase_C)
  
  141 - 430
  
  Pfam
  PF00113 (Enolase_C)
IPR020809

Enolase, conserved site
1. PS00164 (ENOLASE)
  
  340 - 353
  
  PROSITE patterns
  PS00164 (ENOLASE)

no IPR

Unintegrated signatures

PTHR11902:SF1 (ENOLASE)

1 - 425

PANTHER
PTHR11902:SF1 (ENOLASE)
SFLDF00002 (enolase)

2 - 417

SFLD
SFLDF00002 (enolase)

Residue annotation

dimer interface cd...

8V

dimer interface
8V, 10R, 11E, 12I, 13L, 14D, 15S, 16R, 17G, 18N, 22E, 34R, 156A, 157D, 158S, 179M, 180Q, 183C, 184E, 187H, 188H, 201N, 202V, 209A, 212K, 375E, 376T, 377E, 400R, 401T, 402D, 404M, 405A, 408N, 411L, 412R, 415Q
CDD
cd03313 (enolase)

10R

dimer interface
8V, 10R, 11E, 12I, 13L, 14D, 15S, 16R, 17G, 18N, 22E, 34R, 156A, 157D, 158S, 179M, 180Q, 183C, 184E, 187H, 188H, 201N, 202V, 209A, 212K, 375E, 376T, 377E, 400R, 401T, 402D, 404M, 405A, 408N, 411L, 412R, 415Q
CDD
cd03313 (enolase)

11E

dimer interface
8V, 10R, 11E, 12I, 13L, 14D, 15S, 16R, 17G, 18N, 22E, 34R, 156A, 157D, 158S, 179M, 180Q, 183C, 184E, 187H, 188H, 201N, 202V, 209A, 212K, 375E, 376T, 377E, 400R, 401T, 402D, 404M, 405A, 408N, 411L, 412R, 415Q
CDD
cd03313 (enolase)

12I

dimer interface
8V, 10R, 11E, 12I, 13L, 14D, 15S, 16R, 17G, 18N, 22E, 34R, 156A, 157D, 158S, 179M, 180Q, 183C, 184E, 187H, 188H, 201N, 202V, 209A, 212K, 375E, 376T, 377E, 400R, 401T, 402D, 404M, 405A, 408N, 411L, 412R, 415Q
CDD
cd03313 (enolase)

13L

dimer interface
8V, 10R, 11E, 12I, 13L, 14D, 15S, 16R, 17G, 18N, 22E, 34R, 156A, 157D, 158S, 179M, 180Q, 183C, 184E, 187H, 188H, 201N, 202V, 209A, 212K, 375E, 376T, 377E, 400R, 401T, 402D, 404M, 405A, 408N, 411L, 412R, 415Q
CDD
cd03313 (enolase)

14D

dimer interface
8V, 10R, 11E, 12I, 13L, 14D, 15S, 16R, 17G, 18N, 22E, 34R, 156A, 157D, 158S, 179M, 180Q, 183C, 184E, 187H, 188H, 201N, 202V, 209A, 212K, 375E, 376T, 377E, 400R, 401T, 402D, 404M, 405A, 408N, 411L, 412R, 415Q
CDD
cd03313 (enolase)

15S

dimer interface
8V, 10R, 11E, 12I, 13L, 14D, 15S, 16R, 17G, 18N, 22E, 34R, 156A, 157D, 158S, 179M, 180Q, 183C, 184E, 187H, 188H, 201N, 202V, 209A, 212K, 375E, 376T, 377E, 400R, 401T, 402D, 404M, 405A, 408N, 411L, 412R, 415Q
CDD
cd03313 (enolase)

16R

dimer interface
8V, 10R, 11E, 12I, 13L, 14D, 15S, 16R, 17G, 18N, 22E, 34R, 156A, 157D, 158S, 179M, 180Q, 183C, 184E, 187H, 188H, 201N, 202V, 209A, 212K, 375E, 376T, 377E, 400R, 401T, 402D, 404M, 405A, 408N, 411L, 412R, 415Q
CDD
cd03313 (enolase)

17G

dimer interface
8V, 10R, 11E, 12I, 13L, 14D, 15S, 16R, 17G, 18N, 22E, 34R, 156A, 157D, 158S, 179M, 180Q, 183C, 184E, 187H, 188H, 201N, 202V, 209A, 212K, 375E, 376T, 377E, 400R, 401T, 402D, 404M, 405A, 408N, 411L, 412R, 415Q
CDD
cd03313 (enolase)

18N

dimer interface
8V, 10R, 11E, 12I, 13L, 14D, 15S, 16R, 17G, 18N, 22E, 34R, 156A, 157D, 158S, 179M, 180Q, 183C, 184E, 187H, 188H, 201N, 202V, 209A, 212K, 375E, 376T, 377E, 400R, 401T, 402D, 404M, 405A, 408N, 411L, 412R, 415Q
CDD
cd03313 (enolase)

22E

dimer interface
8V, 10R, 11E, 12I, 13L, 14D, 15S, 16R, 17G, 18N, 22E, 34R, 156A, 157D, 158S, 179M, 180Q, 183C, 184E, 187H, 188H, 201N, 202V, 209A, 212K, 375E, 376T, 377E, 400R, 401T, 402D, 404M, 405A, 408N, 411L, 412R, 415Q
CDD
cd03313 (enolase)

34R

dimer interface
8V, 10R, 11E, 12I, 13L, 14D, 15S, 16R, 17G, 18N, 22E, 34R, 156A, 157D, 158S, 179M, 180Q, 183C, 184E, 187H, 188H, 201N, 202V, 209A, 212K, 375E, 376T, 377E, 400R, 401T, 402D, 404M, 405A, 408N, 411L, 412R, 415Q
CDD
cd03313 (enolase)

156A

dimer interface
8V, 10R, 11E, 12I, 13L, 14D, 15S, 16R, 17G, 18N, 22E, 34R, 156A, 157D, 158S, 179M, 180Q, 183C, 184E, 187H, 188H, 201N, 202V, 209A, 212K, 375E, 376T, 377E, 400R, 401T, 402D, 404M, 405A, 408N, 411L, 412R, 415Q
CDD
cd03313 (enolase)

157D

dimer interface
8V, 10R, 11E, 12I, 13L, 14D, 15S, 16R, 17G, 18N, 22E, 34R, 156A, 157D, 158S, 179M, 180Q, 183C, 184E, 187H, 188H, 201N, 202V, 209A, 212K, 375E, 376T, 377E, 400R, 401T, 402D, 404M, 405A, 408N, 411L, 412R, 415Q
CDD
cd03313 (enolase)

158S

dimer interface
8V, 10R, 11E, 12I, 13L, 14D, 15S, 16R, 17G, 18N, 22E, 34R, 156A, 157D, 158S, 179M, 180Q, 183C, 184E, 187H, 188H, 201N, 202V, 209A, 212K, 375E, 376T, 377E, 400R, 401T, 402D, 404M, 405A, 408N, 411L, 412R, 415Q
CDD
cd03313 (enolase)

179M

dimer interface
8V, 10R, 11E, 12I, 13L, 14D, 15S, 16R, 17G, 18N, 22E, 34R, 156A, 157D, 158S, 179M, 180Q, 183C, 184E, 187H, 188H, 201N, 202V, 209A, 212K, 375E, 376T, 377E, 400R, 401T, 402D, 404M, 405A, 408N, 411L, 412R, 415Q
CDD
cd03313 (enolase)

180Q

dimer interface
8V, 10R, 11E, 12I, 13L, 14D, 15S, 16R, 17G, 18N, 22E, 34R, 156A, 157D, 158S, 179M, 180Q, 183C, 184E, 187H, 188H, 201N, 202V, 209A, 212K, 375E, 376T, 377E, 400R, 401T, 402D, 404M, 405A, 408N, 411L, 412R, 415Q
CDD
cd03313 (enolase)

183C

dimer interface
8V, 10R, 11E, 12I, 13L, 14D, 15S, 16R, 17G, 18N, 22E, 34R, 156A, 157D, 158S, 179M, 180Q, 183C, 184E, 187H, 188H, 201N, 202V, 209A, 212K, 375E, 376T, 377E, 400R, 401T, 402D, 404M, 405A, 408N, 411L, 412R, 415Q
CDD
cd03313 (enolase)

184E

dimer interface
8V, 10R, 11E, 12I, 13L, 14D, 15S, 16R, 17G, 18N, 22E, 34R, 156A, 157D, 158S, 179M, 180Q, 183C, 184E, 187H, 188H, 201N, 202V, 209A, 212K, 375E, 376T, 377E, 400R, 401T, 402D, 404M, 405A, 408N, 411L, 412R, 415Q
CDD
cd03313 (enolase)

187H

dimer interface
8V, 10R, 11E, 12I, 13L, 14D, 15S, 16R, 17G, 18N, 22E, 34R, 156A, 157D, 158S, 179M, 180Q, 183C, 184E, 187H, 188H, 201N, 202V, 209A, 212K, 375E, 376T, 377E, 400R, 401T, 402D, 404M, 405A, 408N, 411L, 412R, 415Q
CDD
cd03313 (enolase)

188H

dimer interface
8V, 10R, 11E, 12I, 13L, 14D, 15S, 16R, 17G, 18N, 22E, 34R, 156A, 157D, 158S, 179M, 180Q, 183C, 184E, 187H, 188H, 201N, 202V, 209A, 212K, 375E, 376T, 377E, 400R, 401T, 402D, 404M, 405A, 408N, 411L, 412R, 415Q
CDD
cd03313 (enolase)

201N

dimer interface
8V, 10R, 11E, 12I, 13L, 14D, 15S, 16R, 17G, 18N, 22E, 34R, 156A, 157D, 158S, 179M, 180Q, 183C, 184E, 187H, 188H, 201N, 202V, 209A, 212K, 375E, 376T, 377E, 400R, 401T, 402D, 404M, 405A, 408N, 411L, 412R, 415Q
CDD
cd03313 (enolase)

202V

dimer interface
8V, 10R, 11E, 12I, 13L, 14D, 15S, 16R, 17G, 18N, 22E, 34R, 156A, 157D, 158S, 179M, 180Q, 183C, 184E, 187H, 188H, 201N, 202V, 209A, 212K, 375E, 376T, 377E, 400R, 401T, 402D, 404M, 405A, 408N, 411L, 412R, 415Q
CDD
cd03313 (enolase)

209A

dimer interface
8V, 10R, 11E, 12I, 13L, 14D, 15S, 16R, 17G, 18N, 22E, 34R, 156A, 157D, 158S, 179M, 180Q, 183C, 184E, 187H, 188H, 201N, 202V, 209A, 212K, 375E, 376T, 377E, 400R, 401T, 402D, 404M, 405A, 408N, 411L, 412R, 415Q
CDD
cd03313 (enolase)

212K

dimer interface
8V, 10R, 11E, 12I, 13L, 14D, 15S, 16R, 17G, 18N, 22E, 34R, 156A, 157D, 158S, 179M, 180Q, 183C, 184E, 187H, 188H, 201N, 202V, 209A, 212K, 375E, 376T, 377E, 400R, 401T, 402D, 404M, 405A, 408N, 411L, 412R, 415Q
CDD
cd03313 (enolase)

375E

dimer interface
8V, 10R, 11E, 12I, 13L, 14D, 15S, 16R, 17G, 18N, 22E, 34R, 156A, 157D, 158S, 179M, 180Q, 183C, 184E, 187H, 188H, 201N, 202V, 209A, 212K, 375E, 376T, 377E, 400R, 401T, 402D, 404M, 405A, 408N, 411L, 412R, 415Q
CDD
cd03313 (enolase)

376T

dimer interface
8V, 10R, 11E, 12I, 13L, 14D, 15S, 16R, 17G, 18N, 22E, 34R, 156A, 157D, 158S, 179M, 180Q, 183C, 184E, 187H, 188H, 201N, 202V, 209A, 212K, 375E, 376T, 377E, 400R, 401T, 402D, 404M, 405A, 408N, 411L, 412R, 415Q
CDD
cd03313 (enolase)

377E

dimer interface
8V, 10R, 11E, 12I, 13L, 14D, 15S, 16R, 17G, 18N, 22E, 34R, 156A, 157D, 158S, 179M, 180Q, 183C, 184E, 187H, 188H, 201N, 202V, 209A, 212K, 375E, 376T, 377E, 400R, 401T, 402D, 404M, 405A, 408N, 411L, 412R, 415Q
CDD
cd03313 (enolase)

400R

dimer interface
8V, 10R, 11E, 12I, 13L, 14D, 15S, 16R, 17G, 18N, 22E, 34R, 156A, 157D, 158S, 179M, 180Q, 183C, 184E, 187H, 188H, 201N, 202V, 209A, 212K, 375E, 376T, 377E, 400R, 401T, 402D, 404M, 405A, 408N, 411L, 412R, 415Q
CDD
cd03313 (enolase)

401T

dimer interface
8V, 10R, 11E, 12I, 13L, 14D, 15S, 16R, 17G, 18N, 22E, 34R, 156A, 157D, 158S, 179M, 180Q, 183C, 184E, 187H, 188H, 201N, 202V, 209A, 212K, 375E, 376T, 377E, 400R, 401T, 402D, 404M, 405A, 408N, 411L, 412R, 415Q
CDD
cd03313 (enolase)

402D

dimer interface
8V, 10R, 11E, 12I, 13L, 14D, 15S, 16R, 17G, 18N, 22E, 34R, 156A, 157D, 158S, 179M, 180Q, 183C, 184E, 187H, 188H, 201N, 202V, 209A, 212K, 375E, 376T, 377E, 400R, 401T, 402D, 404M, 405A, 408N, 411L, 412R, 415Q
CDD
cd03313 (enolase)

404M

dimer interface
8V, 10R, 11E, 12I, 13L, 14D, 15S, 16R, 17G, 18N, 22E, 34R, 156A, 157D, 158S, 179M, 180Q, 183C, 184E, 187H, 188H, 201N, 202V, 209A, 212K, 375E, 376T, 377E, 400R, 401T, 402D, 404M, 405A, 408N, 411L, 412R, 415Q
CDD
cd03313 (enolase)

405A

dimer interface
8V, 10R, 11E, 12I, 13L, 14D, 15S, 16R, 17G, 18N, 22E, 34R, 156A, 157D, 158S, 179M, 180Q, 183C, 184E, 187H, 188H, 201N, 202V, 209A, 212K, 375E, 376T, 377E, 400R, 401T, 402D, 404M, 405A, 408N, 411L, 412R, 415Q
CDD
cd03313 (enolase)

408N

dimer interface
8V, 10R, 11E, 12I, 13L, 14D, 15S, 16R, 17G, 18N, 22E, 34R, 156A, 157D, 158S, 179M, 180Q, 183C, 184E, 187H, 188H, 201N, 202V, 209A, 212K, 375E, 376T, 377E, 400R, 401T, 402D, 404M, 405A, 408N, 411L, 412R, 415Q
CDD
cd03313 (enolase)

411L

dimer interface
8V, 10R, 11E, 12I, 13L, 14D, 15S, 16R, 17G, 18N, 22E, 34R, 156A, 157D, 158S, 179M, 180Q, 183C, 184E, 187H, 188H, 201N, 202V, 209A, 212K, 375E, 376T, 377E, 400R, 401T, 402D, 404M, 405A, 408N, 411L, 412R, 415Q
CDD
cd03313 (enolase)

412R

dimer interface
8V, 10R, 11E, 12I, 13L, 14D, 15S, 16R, 17G, 18N, 22E, 34R, 156A, 157D, 158S, 179M, 180Q, 183C, 184E, 187H, 188H, 201N, 202V, 209A, 212K, 375E, 376T, 377E, 400R, 401T, 402D, 404M, 405A, 408N, 411L, 412R, 415Q
CDD
cd03313 (enolase)

415Q

dimer interface
8V, 10R, 11E, 12I, 13L, 14D, 15S, 16R, 17G, 18N, 22E, 34R, 156A, 157D, 158S, 179M, 180Q, 183C, 184E, 187H, 188H, 201N, 202V, 209A, 212K, 375E, 376T, 377E, 400R, 401T, 402D, 404M, 405A, 408N, 411L, 412R, 415Q
CDD
cd03313 (enolase)
metal binding site...

42S

metal binding site
42S, 243D, 291E, 318D
CDD
cd03313 (enolase)

243D

metal binding site
42S, 243D, 291E, 318D
CDD
cd03313 (enolase)

291E

metal binding site
42S, 243D, 291E, 318D
CDD
cd03313 (enolase)

318D

metal binding site
42S, 243D, 291E, 318D
CDD
cd03313 (enolase)
SFLDF00002

42S

SFLD_Res01
42S, 205E, 243D, 291E, 318D, 343K
SFLD
SFLDF00002 (enolase)

205E

SFLD_Res01
42S, 205E, 243D, 291E, 318D, 343K
SFLD
SFLDF00002 (enolase)

243D

SFLD_Res01
42S, 205E, 243D, 291E, 318D, 343K
SFLD
SFLDF00002 (enolase)

291E

SFLD_Res01
42S, 205E, 243D, 291E, 318D, 343K
SFLD
SFLDF00002 (enolase)

318D

SFLD_Res01
42S, 205E, 243D, 291E, 318D, 343K
SFLD
SFLDF00002 (enolase)

343K

SFLD_Res01
42S, 205E, 243D, 291E, 318D, 343K
SFLD
SFLDF00002 (enolase)
substrate binding ...

155H

substrate binding pocket
155H, 205E, 343K, 371H, 372R, 373S, 394K
CDD
cd03313 (enolase)

205E

substrate binding pocket
155H, 205E, 343K, 371H, 372R, 373S, 394K
CDD
cd03313 (enolase)

343K

substrate binding pocket
155H, 205E, 343K, 371H, 372R, 373S, 394K
CDD
cd03313 (enolase)

371H

substrate binding pocket
155H, 205E, 343K, 371H, 372R, 373S, 394K
CDD
cd03313 (enolase)

372R

substrate binding pocket
155H, 205E, 343K, 371H, 372R, 373S, 394K
CDD
cd03313 (enolase)

373S

substrate binding pocket
155H, 205E, 343K, 371H, 372R, 373S, 394K
CDD
cd03313 (enolase)

394K

substrate binding pocket
155H, 205E, 343K, 371H, 372R, 373S, 394K
CDD
cd03313 (enolase)
SFLDG00178

205E

SFLD_Res01
205E, 243D, 291E, 318D, 343K
SFLD
SFLDG00178 (enolase)

243D

SFLD_Res01
205E, 243D, 291E, 318D, 343K
SFLD
SFLDG00178 (enolase)

291E

SFLD_Res01
205E, 243D, 291E, 318D, 343K
SFLD
SFLDG00178 (enolase)

318D

SFLD_Res01
205E, 243D, 291E, 318D, 343K
SFLD
SFLDG00178 (enolase)

343K

SFLD_Res01
205E, 243D, 291E, 318D, 343K
SFLD
SFLDG00178 (enolase)
SFLDS00001

243D

SFLD_Res03
243D, 291E, 318D
SFLD
SFLDS00001 (Enolase)

291E

SFLD_Res03
243D, 291E, 318D
SFLD
SFLDS00001 (Enolase)

318D

SFLD_Res03
243D, 291E, 318D
SFLD
SFLDS00001 (Enolase)

GO term prediction

Biological Process

GO:0006096 glycolytic process

Molecular Function

GO:0000287 magnesium ion binding
GO:0004634 phosphopyruvate hydratase activity
GO:0046872 metal ion binding

Cellular Component

GO:0000015 phosphopyruvate hydratase complex

Filter view on

Entry type

Status

Per-residue features

25563_FusoPortal_Gene_1378

Protein family membership

Homologous superfamilies

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component