25563_FusoPortal_Gene_201

Protein

25563_FusoPortal_Gene_201

Length

329 amino acids

Protein family membership

None predicted.

Homologous superfamilies

Homologous superfamily
101 - 298
NAD(P)-binding domain superfamily (IPR036291)

1 50 100 150 200 250 300 329

Domains and repeats

Domain
3 - 328
D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain (IPR006139)
Domain
110 - 297
D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain (IPR006140)

1 50 100 150 200 250 300 329

Detailed signature matches

IPR036291

NAD(P)-binding domain superfamily
1. SSF51735 (NAD(P)-bi...)
  
  101 - 298
  
  SUPERFAMILY
  SSF51735 (NAD(P)-binding Rossmann-fold domains)
IPR006139

D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
1. PF00389 (2-Hacid_dh)
  
  3 - 328
  
  Pfam
  PF00389 (2-Hacid_dh)
IPR006140

D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain
1. PF02826 (2-Hacid_dh_C)
  
  110 - 297
  
  Pfam
  PF02826 (2-Hacid_dh_C)
IPR029753

D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site
1. PS00671 (D_2_HYDROX...)
  
  223 - 239
  
  PROSITE patterns
  PS00671 (D_2_HYDROXYACID_DH_3)
2. PS00670 (D_2_HYDROX...)
  
  194 - 216
  
  PROSITE patterns
  PS00670 (D_2_HYDROXYACID_DH_2)

no IPR

Unintegrated signatures

Coil

321 - 329

COILS
Coil (Coil)
G3DSA:3.40.50...

116 - 300

GENE3D
G3DSA:3.40.50.720 (G3DSA:3.40.50.720)

1 - 115

GENE3D
G3DSA:3.40.50.720 (G3DSA:3.40.50.720)
PTHR43026 (FAMILY N...)

1 - 328

PANTHER
PTHR43026 (FAMILY NOT NAMED)
PTHR43026:SF1 (D-LA...)

1 - 328

PANTHER
PTHR43026:SF1 (D-LACTATE DEHYDROGENASE-RELATED)
SSF52283 (Formate/g...)

2 - 134

SUPERFAMILY
SSF52283 (Formate/glycerate dehydrogenase catalytic domain-like)
cd12183 (LDH_like_2)

1 - 328

CDD
cd12183 (LDH_like_2)

Residue annotation

putative ligand bi...

76C

putative ligand binding site
76C, 77A, 78G, 99Y, 234R, 295H, 298Y
CDD
cd12183 (LDH_like_2)

77A

putative ligand binding site
76C, 77A, 78G, 99Y, 234R, 295H, 298Y
CDD
cd12183 (LDH_like_2)

78G

putative ligand binding site
76C, 77A, 78G, 99Y, 234R, 295H, 298Y
CDD
cd12183 (LDH_like_2)

99Y

putative ligand binding site
76C, 77A, 78G, 99Y, 234R, 295H, 298Y
CDD
cd12183 (LDH_like_2)

234R

putative ligand binding site
76C, 77A, 78G, 99Y, 234R, 295H, 298Y
CDD
cd12183 (LDH_like_2)

295H

putative ligand binding site
76C, 77A, 78G, 99Y, 234R, 295H, 298Y
CDD
cd12183 (LDH_like_2)

298Y

putative ligand binding site
76C, 77A, 78G, 99Y, 234R, 295H, 298Y
CDD
cd12183 (LDH_like_2)
putative NAD bindi...

99Y

putative NAD binding site
99Y, 104V, 150G, 152G, 153R, 154I, 155A, 172Y, 173D, 174P, 204H, 205C, 206P, 207L, 211N, 214L, 232T, 233G, 234R, 258D, 259V, 295H, 297A, 298Y
CDD
cd12183 (LDH_like_2)

104V

putative NAD binding site
99Y, 104V, 150G, 152G, 153R, 154I, 155A, 172Y, 173D, 174P, 204H, 205C, 206P, 207L, 211N, 214L, 232T, 233G, 234R, 258D, 259V, 295H, 297A, 298Y
CDD
cd12183 (LDH_like_2)

150G

putative NAD binding site
99Y, 104V, 150G, 152G, 153R, 154I, 155A, 172Y, 173D, 174P, 204H, 205C, 206P, 207L, 211N, 214L, 232T, 233G, 234R, 258D, 259V, 295H, 297A, 298Y
CDD
cd12183 (LDH_like_2)

152G

putative NAD binding site
99Y, 104V, 150G, 152G, 153R, 154I, 155A, 172Y, 173D, 174P, 204H, 205C, 206P, 207L, 211N, 214L, 232T, 233G, 234R, 258D, 259V, 295H, 297A, 298Y
CDD
cd12183 (LDH_like_2)

153R

putative NAD binding site
99Y, 104V, 150G, 152G, 153R, 154I, 155A, 172Y, 173D, 174P, 204H, 205C, 206P, 207L, 211N, 214L, 232T, 233G, 234R, 258D, 259V, 295H, 297A, 298Y
CDD
cd12183 (LDH_like_2)

154I

putative NAD binding site
99Y, 104V, 150G, 152G, 153R, 154I, 155A, 172Y, 173D, 174P, 204H, 205C, 206P, 207L, 211N, 214L, 232T, 233G, 234R, 258D, 259V, 295H, 297A, 298Y
CDD
cd12183 (LDH_like_2)

155A

putative NAD binding site
99Y, 104V, 150G, 152G, 153R, 154I, 155A, 172Y, 173D, 174P, 204H, 205C, 206P, 207L, 211N, 214L, 232T, 233G, 234R, 258D, 259V, 295H, 297A, 298Y
CDD
cd12183 (LDH_like_2)

172Y

putative NAD binding site
99Y, 104V, 150G, 152G, 153R, 154I, 155A, 172Y, 173D, 174P, 204H, 205C, 206P, 207L, 211N, 214L, 232T, 233G, 234R, 258D, 259V, 295H, 297A, 298Y
CDD
cd12183 (LDH_like_2)

173D

putative NAD binding site
99Y, 104V, 150G, 152G, 153R, 154I, 155A, 172Y, 173D, 174P, 204H, 205C, 206P, 207L, 211N, 214L, 232T, 233G, 234R, 258D, 259V, 295H, 297A, 298Y
CDD
cd12183 (LDH_like_2)

174P

putative NAD binding site
99Y, 104V, 150G, 152G, 153R, 154I, 155A, 172Y, 173D, 174P, 204H, 205C, 206P, 207L, 211N, 214L, 232T, 233G, 234R, 258D, 259V, 295H, 297A, 298Y
CDD
cd12183 (LDH_like_2)

204H

putative NAD binding site
99Y, 104V, 150G, 152G, 153R, 154I, 155A, 172Y, 173D, 174P, 204H, 205C, 206P, 207L, 211N, 214L, 232T, 233G, 234R, 258D, 259V, 295H, 297A, 298Y
CDD
cd12183 (LDH_like_2)

205C

putative NAD binding site
99Y, 104V, 150G, 152G, 153R, 154I, 155A, 172Y, 173D, 174P, 204H, 205C, 206P, 207L, 211N, 214L, 232T, 233G, 234R, 258D, 259V, 295H, 297A, 298Y
CDD
cd12183 (LDH_like_2)

206P

putative NAD binding site
99Y, 104V, 150G, 152G, 153R, 154I, 155A, 172Y, 173D, 174P, 204H, 205C, 206P, 207L, 211N, 214L, 232T, 233G, 234R, 258D, 259V, 295H, 297A, 298Y
CDD
cd12183 (LDH_like_2)

207L

putative NAD binding site
99Y, 104V, 150G, 152G, 153R, 154I, 155A, 172Y, 173D, 174P, 204H, 205C, 206P, 207L, 211N, 214L, 232T, 233G, 234R, 258D, 259V, 295H, 297A, 298Y
CDD
cd12183 (LDH_like_2)

211N

putative NAD binding site
99Y, 104V, 150G, 152G, 153R, 154I, 155A, 172Y, 173D, 174P, 204H, 205C, 206P, 207L, 211N, 214L, 232T, 233G, 234R, 258D, 259V, 295H, 297A, 298Y
CDD
cd12183 (LDH_like_2)

214L

putative NAD binding site
99Y, 104V, 150G, 152G, 153R, 154I, 155A, 172Y, 173D, 174P, 204H, 205C, 206P, 207L, 211N, 214L, 232T, 233G, 234R, 258D, 259V, 295H, 297A, 298Y
CDD
cd12183 (LDH_like_2)

232T

putative NAD binding site
99Y, 104V, 150G, 152G, 153R, 154I, 155A, 172Y, 173D, 174P, 204H, 205C, 206P, 207L, 211N, 214L, 232T, 233G, 234R, 258D, 259V, 295H, 297A, 298Y
CDD
cd12183 (LDH_like_2)

233G

putative NAD binding site
99Y, 104V, 150G, 152G, 153R, 154I, 155A, 172Y, 173D, 174P, 204H, 205C, 206P, 207L, 211N, 214L, 232T, 233G, 234R, 258D, 259V, 295H, 297A, 298Y
CDD
cd12183 (LDH_like_2)

234R

putative NAD binding site
99Y, 104V, 150G, 152G, 153R, 154I, 155A, 172Y, 173D, 174P, 204H, 205C, 206P, 207L, 211N, 214L, 232T, 233G, 234R, 258D, 259V, 295H, 297A, 298Y
CDD
cd12183 (LDH_like_2)

258D

putative NAD binding site
99Y, 104V, 150G, 152G, 153R, 154I, 155A, 172Y, 173D, 174P, 204H, 205C, 206P, 207L, 211N, 214L, 232T, 233G, 234R, 258D, 259V, 295H, 297A, 298Y
CDD
cd12183 (LDH_like_2)

259V

putative NAD binding site
99Y, 104V, 150G, 152G, 153R, 154I, 155A, 172Y, 173D, 174P, 204H, 205C, 206P, 207L, 211N, 214L, 232T, 233G, 234R, 258D, 259V, 295H, 297A, 298Y
CDD
cd12183 (LDH_like_2)

295H

putative NAD binding site
99Y, 104V, 150G, 152G, 153R, 154I, 155A, 172Y, 173D, 174P, 204H, 205C, 206P, 207L, 211N, 214L, 232T, 233G, 234R, 258D, 259V, 295H, 297A, 298Y
CDD
cd12183 (LDH_like_2)

297A

putative NAD binding site
99Y, 104V, 150G, 152G, 153R, 154I, 155A, 172Y, 173D, 174P, 204H, 205C, 206P, 207L, 211N, 214L, 232T, 233G, 234R, 258D, 259V, 295H, 297A, 298Y
CDD
cd12183 (LDH_like_2)

298Y

putative NAD binding site
99Y, 104V, 150G, 152G, 153R, 154I, 155A, 172Y, 173D, 174P, 204H, 205C, 206P, 207L, 211N, 214L, 232T, 233G, 234R, 258D, 259V, 295H, 297A, 298Y
CDD
cd12183 (LDH_like_2)
catalytic site cd1...

234R

catalytic site
234R, 263E, 295H
CDD
cd12183 (LDH_like_2)

263E

catalytic site
234R, 263E, 295H
CDD
cd12183 (LDH_like_2)

295H

catalytic site
234R, 263E, 295H
CDD
cd12183 (LDH_like_2)

GO term prediction

Biological Process

GO:0008152 metabolic process
GO:0055114 oxidation-reduction process

Molecular Function

GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0051287 NAD binding

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features

25563_FusoPortal_Gene_201

Protein family membership

Homologous superfamilies

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component