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Protein

25563_FusoPortal_Gene_484

Length

172 amino acids

Protein family membership

ATP:cob(I)alamin adenosyltransferase CobA/CobO/ButR (IPR003724)

Homologous superfamilies

Homologous superfamily
3 - 171
P-loop containing nucleoside triphosphate hydrolase (IPR027417)

1 20 40 60 80 100 120 140 160 172

Domains and repeats

None predicted.

Detailed signature matches

IPR027417

P-loop containing nucleoside triphosphate hydrolase

SSF52540 (P-loop co...)

3 - 171

SUPERFAMILY
SSF52540 (P-loop containing nucleoside triphosphate hydrolases)

IPR003724

ATP:cob(I)alamin adenosyltransferase CobA/CobO/ButR

PF02572 (CobA_CobO_...)

2 - 171

Pfam
PF02572 (CobA_CobO_BtuR)
cd00561 (CobA_CobO_...)

1 - 160

CDD
cd00561 (CobA_CobO_BtuR)
PIRSF015617 (Adenos...)

1 - 172

PIRSF
PIRSF015617 (Adenosyltransferase_CobA)

no IPR

Unintegrated signatures

G3DSA:3.40.50...

1 - 171

GENE3D
G3DSA:3.40.50.300 (G3DSA:3.40.50.300)

Residue annotation

homodimer interfac...

2K

homodimer interface
2K, 13K, 17T, 21G, 22L, 24V, 25R, 26A, 27L, 28G, 29N, 43N, 45G, 46E, 48R, 49T, 131E, 144I, 145E, 147A, 148D, 149L, 150V, 151T, 152E, 153M, 154C, 156V, 157K, 159Y
CDD
cd00561 (CobA_CobO_BtuR)

13K

homodimer interface
2K, 13K, 17T, 21G, 22L, 24V, 25R, 26A, 27L, 28G, 29N, 43N, 45G, 46E, 48R, 49T, 131E, 144I, 145E, 147A, 148D, 149L, 150V, 151T, 152E, 153M, 154C, 156V, 157K, 159Y
CDD
cd00561 (CobA_CobO_BtuR)

17T

homodimer interface
2K, 13K, 17T, 21G, 22L, 24V, 25R, 26A, 27L, 28G, 29N, 43N, 45G, 46E, 48R, 49T, 131E, 144I, 145E, 147A, 148D, 149L, 150V, 151T, 152E, 153M, 154C, 156V, 157K, 159Y
CDD
cd00561 (CobA_CobO_BtuR)

21G

homodimer interface
2K, 13K, 17T, 21G, 22L, 24V, 25R, 26A, 27L, 28G, 29N, 43N, 45G, 46E, 48R, 49T, 131E, 144I, 145E, 147A, 148D, 149L, 150V, 151T, 152E, 153M, 154C, 156V, 157K, 159Y
CDD
cd00561 (CobA_CobO_BtuR)

22L

homodimer interface
2K, 13K, 17T, 21G, 22L, 24V, 25R, 26A, 27L, 28G, 29N, 43N, 45G, 46E, 48R, 49T, 131E, 144I, 145E, 147A, 148D, 149L, 150V, 151T, 152E, 153M, 154C, 156V, 157K, 159Y
CDD
cd00561 (CobA_CobO_BtuR)

24V

homodimer interface
2K, 13K, 17T, 21G, 22L, 24V, 25R, 26A, 27L, 28G, 29N, 43N, 45G, 46E, 48R, 49T, 131E, 144I, 145E, 147A, 148D, 149L, 150V, 151T, 152E, 153M, 154C, 156V, 157K, 159Y
CDD
cd00561 (CobA_CobO_BtuR)

25R

homodimer interface
2K, 13K, 17T, 21G, 22L, 24V, 25R, 26A, 27L, 28G, 29N, 43N, 45G, 46E, 48R, 49T, 131E, 144I, 145E, 147A, 148D, 149L, 150V, 151T, 152E, 153M, 154C, 156V, 157K, 159Y
CDD
cd00561 (CobA_CobO_BtuR)

26A

homodimer interface
2K, 13K, 17T, 21G, 22L, 24V, 25R, 26A, 27L, 28G, 29N, 43N, 45G, 46E, 48R, 49T, 131E, 144I, 145E, 147A, 148D, 149L, 150V, 151T, 152E, 153M, 154C, 156V, 157K, 159Y
CDD
cd00561 (CobA_CobO_BtuR)

27L

homodimer interface
2K, 13K, 17T, 21G, 22L, 24V, 25R, 26A, 27L, 28G, 29N, 43N, 45G, 46E, 48R, 49T, 131E, 144I, 145E, 147A, 148D, 149L, 150V, 151T, 152E, 153M, 154C, 156V, 157K, 159Y
CDD
cd00561 (CobA_CobO_BtuR)

28G

homodimer interface
2K, 13K, 17T, 21G, 22L, 24V, 25R, 26A, 27L, 28G, 29N, 43N, 45G, 46E, 48R, 49T, 131E, 144I, 145E, 147A, 148D, 149L, 150V, 151T, 152E, 153M, 154C, 156V, 157K, 159Y
CDD
cd00561 (CobA_CobO_BtuR)

29N

homodimer interface
2K, 13K, 17T, 21G, 22L, 24V, 25R, 26A, 27L, 28G, 29N, 43N, 45G, 46E, 48R, 49T, 131E, 144I, 145E, 147A, 148D, 149L, 150V, 151T, 152E, 153M, 154C, 156V, 157K, 159Y
CDD
cd00561 (CobA_CobO_BtuR)

43N

homodimer interface
2K, 13K, 17T, 21G, 22L, 24V, 25R, 26A, 27L, 28G, 29N, 43N, 45G, 46E, 48R, 49T, 131E, 144I, 145E, 147A, 148D, 149L, 150V, 151T, 152E, 153M, 154C, 156V, 157K, 159Y
CDD
cd00561 (CobA_CobO_BtuR)

45G

homodimer interface
2K, 13K, 17T, 21G, 22L, 24V, 25R, 26A, 27L, 28G, 29N, 43N, 45G, 46E, 48R, 49T, 131E, 144I, 145E, 147A, 148D, 149L, 150V, 151T, 152E, 153M, 154C, 156V, 157K, 159Y
CDD
cd00561 (CobA_CobO_BtuR)

46E

homodimer interface
2K, 13K, 17T, 21G, 22L, 24V, 25R, 26A, 27L, 28G, 29N, 43N, 45G, 46E, 48R, 49T, 131E, 144I, 145E, 147A, 148D, 149L, 150V, 151T, 152E, 153M, 154C, 156V, 157K, 159Y
CDD
cd00561 (CobA_CobO_BtuR)

48R

homodimer interface
2K, 13K, 17T, 21G, 22L, 24V, 25R, 26A, 27L, 28G, 29N, 43N, 45G, 46E, 48R, 49T, 131E, 144I, 145E, 147A, 148D, 149L, 150V, 151T, 152E, 153M, 154C, 156V, 157K, 159Y
CDD
cd00561 (CobA_CobO_BtuR)

49T

homodimer interface
2K, 13K, 17T, 21G, 22L, 24V, 25R, 26A, 27L, 28G, 29N, 43N, 45G, 46E, 48R, 49T, 131E, 144I, 145E, 147A, 148D, 149L, 150V, 151T, 152E, 153M, 154C, 156V, 157K, 159Y
CDD
cd00561 (CobA_CobO_BtuR)

131E

homodimer interface
2K, 13K, 17T, 21G, 22L, 24V, 25R, 26A, 27L, 28G, 29N, 43N, 45G, 46E, 48R, 49T, 131E, 144I, 145E, 147A, 148D, 149L, 150V, 151T, 152E, 153M, 154C, 156V, 157K, 159Y
CDD
cd00561 (CobA_CobO_BtuR)

144I

homodimer interface
2K, 13K, 17T, 21G, 22L, 24V, 25R, 26A, 27L, 28G, 29N, 43N, 45G, 46E, 48R, 49T, 131E, 144I, 145E, 147A, 148D, 149L, 150V, 151T, 152E, 153M, 154C, 156V, 157K, 159Y
CDD
cd00561 (CobA_CobO_BtuR)

145E

homodimer interface
2K, 13K, 17T, 21G, 22L, 24V, 25R, 26A, 27L, 28G, 29N, 43N, 45G, 46E, 48R, 49T, 131E, 144I, 145E, 147A, 148D, 149L, 150V, 151T, 152E, 153M, 154C, 156V, 157K, 159Y
CDD
cd00561 (CobA_CobO_BtuR)

147A

homodimer interface
2K, 13K, 17T, 21G, 22L, 24V, 25R, 26A, 27L, 28G, 29N, 43N, 45G, 46E, 48R, 49T, 131E, 144I, 145E, 147A, 148D, 149L, 150V, 151T, 152E, 153M, 154C, 156V, 157K, 159Y
CDD
cd00561 (CobA_CobO_BtuR)

148D

homodimer interface
2K, 13K, 17T, 21G, 22L, 24V, 25R, 26A, 27L, 28G, 29N, 43N, 45G, 46E, 48R, 49T, 131E, 144I, 145E, 147A, 148D, 149L, 150V, 151T, 152E, 153M, 154C, 156V, 157K, 159Y
CDD
cd00561 (CobA_CobO_BtuR)

149L

homodimer interface
2K, 13K, 17T, 21G, 22L, 24V, 25R, 26A, 27L, 28G, 29N, 43N, 45G, 46E, 48R, 49T, 131E, 144I, 145E, 147A, 148D, 149L, 150V, 151T, 152E, 153M, 154C, 156V, 157K, 159Y
CDD
cd00561 (CobA_CobO_BtuR)

150V

homodimer interface
2K, 13K, 17T, 21G, 22L, 24V, 25R, 26A, 27L, 28G, 29N, 43N, 45G, 46E, 48R, 49T, 131E, 144I, 145E, 147A, 148D, 149L, 150V, 151T, 152E, 153M, 154C, 156V, 157K, 159Y
CDD
cd00561 (CobA_CobO_BtuR)

151T

homodimer interface
2K, 13K, 17T, 21G, 22L, 24V, 25R, 26A, 27L, 28G, 29N, 43N, 45G, 46E, 48R, 49T, 131E, 144I, 145E, 147A, 148D, 149L, 150V, 151T, 152E, 153M, 154C, 156V, 157K, 159Y
CDD
cd00561 (CobA_CobO_BtuR)

152E

homodimer interface
2K, 13K, 17T, 21G, 22L, 24V, 25R, 26A, 27L, 28G, 29N, 43N, 45G, 46E, 48R, 49T, 131E, 144I, 145E, 147A, 148D, 149L, 150V, 151T, 152E, 153M, 154C, 156V, 157K, 159Y
CDD
cd00561 (CobA_CobO_BtuR)

153M

homodimer interface
2K, 13K, 17T, 21G, 22L, 24V, 25R, 26A, 27L, 28G, 29N, 43N, 45G, 46E, 48R, 49T, 131E, 144I, 145E, 147A, 148D, 149L, 150V, 151T, 152E, 153M, 154C, 156V, 157K, 159Y
CDD
cd00561 (CobA_CobO_BtuR)

154C

homodimer interface
2K, 13K, 17T, 21G, 22L, 24V, 25R, 26A, 27L, 28G, 29N, 43N, 45G, 46E, 48R, 49T, 131E, 144I, 145E, 147A, 148D, 149L, 150V, 151T, 152E, 153M, 154C, 156V, 157K, 159Y
CDD
cd00561 (CobA_CobO_BtuR)

156V

homodimer interface
2K, 13K, 17T, 21G, 22L, 24V, 25R, 26A, 27L, 28G, 29N, 43N, 45G, 46E, 48R, 49T, 131E, 144I, 145E, 147A, 148D, 149L, 150V, 151T, 152E, 153M, 154C, 156V, 157K, 159Y
CDD
cd00561 (CobA_CobO_BtuR)

157K

homodimer interface
2K, 13K, 17T, 21G, 22L, 24V, 25R, 26A, 27L, 28G, 29N, 43N, 45G, 46E, 48R, 49T, 131E, 144I, 145E, 147A, 148D, 149L, 150V, 151T, 152E, 153M, 154C, 156V, 157K, 159Y
CDD
cd00561 (CobA_CobO_BtuR)

159Y

homodimer interface
2K, 13K, 17T, 21G, 22L, 24V, 25R, 26A, 27L, 28G, 29N, 43N, 45G, 46E, 48R, 49T, 131E, 144I, 145E, 147A, 148D, 149L, 150V, 151T, 152E, 153M, 154C, 156V, 157K, 159Y
CDD
cd00561 (CobA_CobO_BtuR)
Walker A motif cd0...

10G

Walker A motif
10G, 11N, 12G, 13K, 14G, 15K, 16T
CDD
cd00561 (CobA_CobO_BtuR)

11N

Walker A motif
10G, 11N, 12G, 13K, 14G, 15K, 16T
CDD
cd00561 (CobA_CobO_BtuR)

12G

Walker A motif
10G, 11N, 12G, 13K, 14G, 15K, 16T
CDD
cd00561 (CobA_CobO_BtuR)

13K

Walker A motif
10G, 11N, 12G, 13K, 14G, 15K, 16T
CDD
cd00561 (CobA_CobO_BtuR)

14G

Walker A motif
10G, 11N, 12G, 13K, 14G, 15K, 16T
CDD
cd00561 (CobA_CobO_BtuR)

15K

Walker A motif
10G, 11N, 12G, 13K, 14G, 15K, 16T
CDD
cd00561 (CobA_CobO_BtuR)

16T

Walker A motif
10G, 11N, 12G, 13K, 14G, 15K, 16T
CDD
cd00561 (CobA_CobO_BtuR)
ATP binding site c...

13K

ATP binding site
13K, 15K, 16T, 17T, 25R, 104E
CDD
cd00561 (CobA_CobO_BtuR)

15K

ATP binding site
13K, 15K, 16T, 17T, 25R, 104E
CDD
cd00561 (CobA_CobO_BtuR)

16T

ATP binding site
13K, 15K, 16T, 17T, 25R, 104E
CDD
cd00561 (CobA_CobO_BtuR)

17T

ATP binding site
13K, 15K, 16T, 17T, 25R, 104E
CDD
cd00561 (CobA_CobO_BtuR)

25R

ATP binding site
13K, 15K, 16T, 17T, 25R, 104E
CDD
cd00561 (CobA_CobO_BtuR)

104E

ATP binding site
13K, 15K, 16T, 17T, 25R, 104E
CDD
cd00561 (CobA_CobO_BtuR)
hydroxycobalamin b...

40K

hydroxycobalamin binding site
40K, 42Q, 67I, 107V, 111F, 137R, 160F
CDD
cd00561 (CobA_CobO_BtuR)

42Q

hydroxycobalamin binding site
40K, 42Q, 67I, 107V, 111F, 137R, 160F
CDD
cd00561 (CobA_CobO_BtuR)

67I

hydroxycobalamin binding site
40K, 42Q, 67I, 107V, 111F, 137R, 160F
CDD
cd00561 (CobA_CobO_BtuR)

107V

hydroxycobalamin binding site
40K, 42Q, 67I, 107V, 111F, 137R, 160F
CDD
cd00561 (CobA_CobO_BtuR)

111F

hydroxycobalamin binding site
40K, 42Q, 67I, 107V, 111F, 137R, 160F
CDD
cd00561 (CobA_CobO_BtuR)

137R

hydroxycobalamin binding site
40K, 42Q, 67I, 107V, 111F, 137R, 160F
CDD
cd00561 (CobA_CobO_BtuR)

160F

hydroxycobalamin binding site
40K, 42Q, 67I, 107V, 111F, 137R, 160F
CDD
cd00561 (CobA_CobO_BtuR)
Walker B motif cd0...

99L

Walker B motif
99L, 100V, 101I, 102A, 103D
CDD
cd00561 (CobA_CobO_BtuR)

100V

Walker B motif
99L, 100V, 101I, 102A, 103D
CDD
cd00561 (CobA_CobO_BtuR)

101I

Walker B motif
99L, 100V, 101I, 102A, 103D
CDD
cd00561 (CobA_CobO_BtuR)

102A

Walker B motif
99L, 100V, 101I, 102A, 103D
CDD
cd00561 (CobA_CobO_BtuR)

103D

Walker B motif
99L, 100V, 101I, 102A, 103D
CDD
cd00561 (CobA_CobO_BtuR)

GO term prediction

Biological Process

GO:0009236 cobalamin biosynthetic process

Molecular Function

GO:0005524 ATP binding
GO:0008817 cob(I)yrinic acid a,c-diamide adenosyltransferase activity

Cellular Component