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Protein

25563_FusoPortal_Gene_486

Length

158 amino acids

Protein family membership

None predicted.

Homologous superfamilies

Homologous superfamily
1 - 158
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase superfamily (IPR036571)

1 20 40 60 80 100 120 140 158

Domains and repeats

Domain
2 - 157
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (IPR003526)

1 20 40 60 80 100 120 140 158

Detailed signature matches

IPR036571

2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase superfamily

SSF69765 (IpsF-like)

1 - 157

SUPERFAMILY
SSF69765 (IpsF-like)
G3DSA:3.30.13...

1 - 158

GENE3D
G3DSA:3.30.1330.50 (G3DSA:3.30.1330.50)

IPR003526

2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase

PF02542 (YgbB)

2 - 156

Pfam
PF02542 (YgbB)
cd00554 (MECDP_synt...)

3 - 155

CDD
cd00554 (MECDP_synthase)
MF_00107 (IspF)

2 - 157

HAMAP
MF_00107 (IspF)
TIGR00151

3 - 157

TIGRFAMs
TIGR00151 (TIGR00151)

IPR020555

2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, conserved site

PS01350 (ISPF)

36 - 51

PROSITE patterns
PS01350 (ISPF)

no IPR

Unintegrated signatures

PTHR43181 (FAMILY N...)

2 - 157

PANTHER
PTHR43181 (FAMILY NOT NAMED)

Residue annotation

homotrimer interac...

3R

homotrimer interaction site
3R, 4I, 6N, 8Y, 10V, 11H, 12V, 16G, 51G, 53L, 54S, 56G, 57D, 94N, 96D, 98T, 105K, 107R, 129S, 131K, 132A, 135E, 136E, 137K, 150Y, 152V, 154L
CDD
cd00554 (MECDP_synthase)

4I

homotrimer interaction site
3R, 4I, 6N, 8Y, 10V, 11H, 12V, 16G, 51G, 53L, 54S, 56G, 57D, 94N, 96D, 98T, 105K, 107R, 129S, 131K, 132A, 135E, 136E, 137K, 150Y, 152V, 154L
CDD
cd00554 (MECDP_synthase)

6N

homotrimer interaction site
3R, 4I, 6N, 8Y, 10V, 11H, 12V, 16G, 51G, 53L, 54S, 56G, 57D, 94N, 96D, 98T, 105K, 107R, 129S, 131K, 132A, 135E, 136E, 137K, 150Y, 152V, 154L
CDD
cd00554 (MECDP_synthase)

8Y

homotrimer interaction site
3R, 4I, 6N, 8Y, 10V, 11H, 12V, 16G, 51G, 53L, 54S, 56G, 57D, 94N, 96D, 98T, 105K, 107R, 129S, 131K, 132A, 135E, 136E, 137K, 150Y, 152V, 154L
CDD
cd00554 (MECDP_synthase)

10V

homotrimer interaction site
3R, 4I, 6N, 8Y, 10V, 11H, 12V, 16G, 51G, 53L, 54S, 56G, 57D, 94N, 96D, 98T, 105K, 107R, 129S, 131K, 132A, 135E, 136E, 137K, 150Y, 152V, 154L
CDD
cd00554 (MECDP_synthase)

11H

homotrimer interaction site
3R, 4I, 6N, 8Y, 10V, 11H, 12V, 16G, 51G, 53L, 54S, 56G, 57D, 94N, 96D, 98T, 105K, 107R, 129S, 131K, 132A, 135E, 136E, 137K, 150Y, 152V, 154L
CDD
cd00554 (MECDP_synthase)

12V

homotrimer interaction site
3R, 4I, 6N, 8Y, 10V, 11H, 12V, 16G, 51G, 53L, 54S, 56G, 57D, 94N, 96D, 98T, 105K, 107R, 129S, 131K, 132A, 135E, 136E, 137K, 150Y, 152V, 154L
CDD
cd00554 (MECDP_synthase)

16G

homotrimer interaction site
3R, 4I, 6N, 8Y, 10V, 11H, 12V, 16G, 51G, 53L, 54S, 56G, 57D, 94N, 96D, 98T, 105K, 107R, 129S, 131K, 132A, 135E, 136E, 137K, 150Y, 152V, 154L
CDD
cd00554 (MECDP_synthase)

51G

homotrimer interaction site
3R, 4I, 6N, 8Y, 10V, 11H, 12V, 16G, 51G, 53L, 54S, 56G, 57D, 94N, 96D, 98T, 105K, 107R, 129S, 131K, 132A, 135E, 136E, 137K, 150Y, 152V, 154L
CDD
cd00554 (MECDP_synthase)

53L

homotrimer interaction site
3R, 4I, 6N, 8Y, 10V, 11H, 12V, 16G, 51G, 53L, 54S, 56G, 57D, 94N, 96D, 98T, 105K, 107R, 129S, 131K, 132A, 135E, 136E, 137K, 150Y, 152V, 154L
CDD
cd00554 (MECDP_synthase)

54S

homotrimer interaction site
3R, 4I, 6N, 8Y, 10V, 11H, 12V, 16G, 51G, 53L, 54S, 56G, 57D, 94N, 96D, 98T, 105K, 107R, 129S, 131K, 132A, 135E, 136E, 137K, 150Y, 152V, 154L
CDD
cd00554 (MECDP_synthase)

56G

homotrimer interaction site
3R, 4I, 6N, 8Y, 10V, 11H, 12V, 16G, 51G, 53L, 54S, 56G, 57D, 94N, 96D, 98T, 105K, 107R, 129S, 131K, 132A, 135E, 136E, 137K, 150Y, 152V, 154L
CDD
cd00554 (MECDP_synthase)

57D

homotrimer interaction site
3R, 4I, 6N, 8Y, 10V, 11H, 12V, 16G, 51G, 53L, 54S, 56G, 57D, 94N, 96D, 98T, 105K, 107R, 129S, 131K, 132A, 135E, 136E, 137K, 150Y, 152V, 154L
CDD
cd00554 (MECDP_synthase)

94N

homotrimer interaction site
3R, 4I, 6N, 8Y, 10V, 11H, 12V, 16G, 51G, 53L, 54S, 56G, 57D, 94N, 96D, 98T, 105K, 107R, 129S, 131K, 132A, 135E, 136E, 137K, 150Y, 152V, 154L
CDD
cd00554 (MECDP_synthase)

96D

homotrimer interaction site
3R, 4I, 6N, 8Y, 10V, 11H, 12V, 16G, 51G, 53L, 54S, 56G, 57D, 94N, 96D, 98T, 105K, 107R, 129S, 131K, 132A, 135E, 136E, 137K, 150Y, 152V, 154L
CDD
cd00554 (MECDP_synthase)

98T

homotrimer interaction site
3R, 4I, 6N, 8Y, 10V, 11H, 12V, 16G, 51G, 53L, 54S, 56G, 57D, 94N, 96D, 98T, 105K, 107R, 129S, 131K, 132A, 135E, 136E, 137K, 150Y, 152V, 154L
CDD
cd00554 (MECDP_synthase)

105K

homotrimer interaction site
3R, 4I, 6N, 8Y, 10V, 11H, 12V, 16G, 51G, 53L, 54S, 56G, 57D, 94N, 96D, 98T, 105K, 107R, 129S, 131K, 132A, 135E, 136E, 137K, 150Y, 152V, 154L
CDD
cd00554 (MECDP_synthase)

107R

homotrimer interaction site
3R, 4I, 6N, 8Y, 10V, 11H, 12V, 16G, 51G, 53L, 54S, 56G, 57D, 94N, 96D, 98T, 105K, 107R, 129S, 131K, 132A, 135E, 136E, 137K, 150Y, 152V, 154L
CDD
cd00554 (MECDP_synthase)

129S

homotrimer interaction site
3R, 4I, 6N, 8Y, 10V, 11H, 12V, 16G, 51G, 53L, 54S, 56G, 57D, 94N, 96D, 98T, 105K, 107R, 129S, 131K, 132A, 135E, 136E, 137K, 150Y, 152V, 154L
CDD
cd00554 (MECDP_synthase)

131K

homotrimer interaction site
3R, 4I, 6N, 8Y, 10V, 11H, 12V, 16G, 51G, 53L, 54S, 56G, 57D, 94N, 96D, 98T, 105K, 107R, 129S, 131K, 132A, 135E, 136E, 137K, 150Y, 152V, 154L
CDD
cd00554 (MECDP_synthase)

132A

homotrimer interaction site
3R, 4I, 6N, 8Y, 10V, 11H, 12V, 16G, 51G, 53L, 54S, 56G, 57D, 94N, 96D, 98T, 105K, 107R, 129S, 131K, 132A, 135E, 136E, 137K, 150Y, 152V, 154L
CDD
cd00554 (MECDP_synthase)

135E

homotrimer interaction site
3R, 4I, 6N, 8Y, 10V, 11H, 12V, 16G, 51G, 53L, 54S, 56G, 57D, 94N, 96D, 98T, 105K, 107R, 129S, 131K, 132A, 135E, 136E, 137K, 150Y, 152V, 154L
CDD
cd00554 (MECDP_synthase)

136E

homotrimer interaction site
3R, 4I, 6N, 8Y, 10V, 11H, 12V, 16G, 51G, 53L, 54S, 56G, 57D, 94N, 96D, 98T, 105K, 107R, 129S, 131K, 132A, 135E, 136E, 137K, 150Y, 152V, 154L
CDD
cd00554 (MECDP_synthase)

137K

homotrimer interaction site
3R, 4I, 6N, 8Y, 10V, 11H, 12V, 16G, 51G, 53L, 54S, 56G, 57D, 94N, 96D, 98T, 105K, 107R, 129S, 131K, 132A, 135E, 136E, 137K, 150Y, 152V, 154L
CDD
cd00554 (MECDP_synthase)

150Y

homotrimer interaction site
3R, 4I, 6N, 8Y, 10V, 11H, 12V, 16G, 51G, 53L, 54S, 56G, 57D, 94N, 96D, 98T, 105K, 107R, 129S, 131K, 132A, 135E, 136E, 137K, 150Y, 152V, 154L
CDD
cd00554 (MECDP_synthase)

152V

homotrimer interaction site
3R, 4I, 6N, 8Y, 10V, 11H, 12V, 16G, 51G, 53L, 54S, 56G, 57D, 94N, 96D, 98T, 105K, 107R, 129S, 131K, 132A, 135E, 136E, 137K, 150Y, 152V, 154L
CDD
cd00554 (MECDP_synthase)

154L

homotrimer interaction site
3R, 4I, 6N, 8Y, 10V, 11H, 12V, 16G, 51G, 53L, 54S, 56G, 57D, 94N, 96D, 98T, 105K, 107R, 129S, 131K, 132A, 135E, 136E, 137K, 150Y, 152V, 154L
CDD
cd00554 (MECDP_synthase)
zinc binding site ...

9D

zinc binding site
9D, 11H, 43H
CDD
cd00554 (MECDP_synthase)

11H

zinc binding site
9D, 11H, 43H
CDD
cd00554 (MECDP_synthase)

43H

zinc binding site
9D, 11H, 43H
CDD
cd00554 (MECDP_synthase)
CDP-binding sites ...

57D

CDP-binding sites
57D, 59G, 101L, 102Q, 104P, 105K, 106L, 107R, 132A, 133T, 134T
CDD
cd00554 (MECDP_synthase)

59G

CDP-binding sites
57D, 59G, 101L, 102Q, 104P, 105K, 106L, 107R, 132A, 133T, 134T
CDD
cd00554 (MECDP_synthase)

101L

CDP-binding sites
57D, 59G, 101L, 102Q, 104P, 105K, 106L, 107R, 132A, 133T, 134T
CDD
cd00554 (MECDP_synthase)

102Q

CDP-binding sites
57D, 59G, 101L, 102Q, 104P, 105K, 106L, 107R, 132A, 133T, 134T
CDD
cd00554 (MECDP_synthase)

104P

CDP-binding sites
57D, 59G, 101L, 102Q, 104P, 105K, 106L, 107R, 132A, 133T, 134T
CDD
cd00554 (MECDP_synthase)

105K

CDP-binding sites
57D, 59G, 101L, 102Q, 104P, 105K, 106L, 107R, 132A, 133T, 134T
CDD
cd00554 (MECDP_synthase)

106L

CDP-binding sites
57D, 59G, 101L, 102Q, 104P, 105K, 106L, 107R, 132A, 133T, 134T
CDD
cd00554 (MECDP_synthase)

107R

CDP-binding sites
57D, 59G, 101L, 102Q, 104P, 105K, 106L, 107R, 132A, 133T, 134T
CDD
cd00554 (MECDP_synthase)

132A

CDP-binding sites
57D, 59G, 101L, 102Q, 104P, 105K, 106L, 107R, 132A, 133T, 134T
CDD
cd00554 (MECDP_synthase)

133T

CDP-binding sites
57D, 59G, 101L, 102Q, 104P, 105K, 106L, 107R, 132A, 133T, 134T
CDD
cd00554 (MECDP_synthase)

134T

CDP-binding sites
57D, 59G, 101L, 102Q, 104P, 105K, 106L, 107R, 132A, 133T, 134T
CDD
cd00554 (MECDP_synthase)

GO term prediction

Biological Process

GO:0016114 terpenoid biosynthetic process

Molecular Function

GO:0008685 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity

Cellular Component