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Protein

25563_FusoPortal_Gene_850

Length

477 amino acids

Protein family membership

Peptidase M17, leucine aminopeptidase/peptidase B (IPR011356)
- Peptidase M17, leucine aminopeptidase (IPR023042)

Homologous superfamilies

None predicted.

Domains and repeats

Domain
34 - 133
Peptidase M17, leucyl aminopeptidase, N-terminal (IPR008283)
163 - 467
Peptidase M17, leucyl aminopeptidase, C-terminal (IPR000819)

1 50 100 150 200 250 300 350 400 450 477

Detailed signature matches

IPR011356

Peptidase M17, leucine aminopeptidase/peptidase B

PTHR11963 (LEUCINE ...)

27 - 475

PANTHER
PTHR11963 (LEUCINE AMINOPEPTIDASE-RELATED)
cd00433 (Peptidase_M17)

32 - 472

CDD
cd00433 (Peptidase_M17)
PR00481 (LAMNOPPTDASE)

320 - 340

PRINTS
PR00481 (LAMNOPPTDASE)

349 - 364

PRINTS
PR00481 (LAMNOPPTDASE)

261 - 282

PRINTS
PR00481 (LAMNOPPTDASE)

239 - 256

PRINTS
PR00481 (LAMNOPPTDASE)

298 - 319

PRINTS
PR00481 (LAMNOPPTDASE)

IPR023042

Peptidase M17, leucine aminopeptidase

MF_00181 (Cytosol_p...)

1 - 477

HAMAP
MF_00181 (Cytosol_peptidase_M17)

IPR008283

Peptidase M17, leucyl aminopeptidase, N-terminal

PF02789 (Peptidase_...)

34 - 133

Pfam
PF02789 (Peptidase_M17_N)

IPR000819

Peptidase M17, leucyl aminopeptidase, C-terminal

PS00631 (CYTOSOL_AP)

324 - 331

PROSITE patterns
PS00631 (CYTOSOL_AP)
PF00883 (Peptidase_M17)

163 - 467

Pfam
PF00883 (Peptidase_M17)

no IPR

Unintegrated signatures

G3DSA:3.40.22...

26 - 142

GENE3D
G3DSA:3.40.220.10 (G3DSA:3.40.220.10)
G3DSA:3.40.63...

150 - 476

GENE3D
G3DSA:3.40.630.10 (G3DSA:3.40.630.10)
PTHR11963:SF23 (DIP...)

27 - 475

PANTHER
PTHR11963:SF23 (DIPEPTIDASE B, ISOFORM A)
SSF52949 (Macro dom...)

30 - 136

SUPERFAMILY
SSF52949 (Macro domain-like)
SSF53187 (Zn-depend...)

160 - 474

SUPERFAMILY
SSF53187 (Zn-dependent exopeptidases)

Residue annotation

interface (dimer o...

45K

interface (dimer of trimers)
45K, 46K, 59S, 68T, 83N, 169N, 171P, 172A, 173A, 217A, 219F, 248Y, 254S, 259S, 262L, 265K, 266D, 298E, 300A, 301I, 302G, 303P, 305A, 307R, 308P, 309G, 310D, 311V, 317G, 319T, 323T, 360Y, 361M, 362A, 363L, 364G, 367A, 393W, 394Q, 396P, 401Q, 403K, 404S, 409I, 411D, 420A, 421G, 423S, 458K
CDD
cd00433 (Peptidase_M17)

46K

interface (dimer of trimers)
45K, 46K, 59S, 68T, 83N, 169N, 171P, 172A, 173A, 217A, 219F, 248Y, 254S, 259S, 262L, 265K, 266D, 298E, 300A, 301I, 302G, 303P, 305A, 307R, 308P, 309G, 310D, 311V, 317G, 319T, 323T, 360Y, 361M, 362A, 363L, 364G, 367A, 393W, 394Q, 396P, 401Q, 403K, 404S, 409I, 411D, 420A, 421G, 423S, 458K
CDD
cd00433 (Peptidase_M17)

59S

interface (dimer of trimers)
45K, 46K, 59S, 68T, 83N, 169N, 171P, 172A, 173A, 217A, 219F, 248Y, 254S, 259S, 262L, 265K, 266D, 298E, 300A, 301I, 302G, 303P, 305A, 307R, 308P, 309G, 310D, 311V, 317G, 319T, 323T, 360Y, 361M, 362A, 363L, 364G, 367A, 393W, 394Q, 396P, 401Q, 403K, 404S, 409I, 411D, 420A, 421G, 423S, 458K
CDD
cd00433 (Peptidase_M17)

68T

interface (dimer of trimers)
45K, 46K, 59S, 68T, 83N, 169N, 171P, 172A, 173A, 217A, 219F, 248Y, 254S, 259S, 262L, 265K, 266D, 298E, 300A, 301I, 302G, 303P, 305A, 307R, 308P, 309G, 310D, 311V, 317G, 319T, 323T, 360Y, 361M, 362A, 363L, 364G, 367A, 393W, 394Q, 396P, 401Q, 403K, 404S, 409I, 411D, 420A, 421G, 423S, 458K
CDD
cd00433 (Peptidase_M17)

83N

interface (dimer of trimers)
45K, 46K, 59S, 68T, 83N, 169N, 171P, 172A, 173A, 217A, 219F, 248Y, 254S, 259S, 262L, 265K, 266D, 298E, 300A, 301I, 302G, 303P, 305A, 307R, 308P, 309G, 310D, 311V, 317G, 319T, 323T, 360Y, 361M, 362A, 363L, 364G, 367A, 393W, 394Q, 396P, 401Q, 403K, 404S, 409I, 411D, 420A, 421G, 423S, 458K
CDD
cd00433 (Peptidase_M17)

169N

interface (dimer of trimers)
45K, 46K, 59S, 68T, 83N, 169N, 171P, 172A, 173A, 217A, 219F, 248Y, 254S, 259S, 262L, 265K, 266D, 298E, 300A, 301I, 302G, 303P, 305A, 307R, 308P, 309G, 310D, 311V, 317G, 319T, 323T, 360Y, 361M, 362A, 363L, 364G, 367A, 393W, 394Q, 396P, 401Q, 403K, 404S, 409I, 411D, 420A, 421G, 423S, 458K
CDD
cd00433 (Peptidase_M17)

171P

interface (dimer of trimers)
45K, 46K, 59S, 68T, 83N, 169N, 171P, 172A, 173A, 217A, 219F, 248Y, 254S, 259S, 262L, 265K, 266D, 298E, 300A, 301I, 302G, 303P, 305A, 307R, 308P, 309G, 310D, 311V, 317G, 319T, 323T, 360Y, 361M, 362A, 363L, 364G, 367A, 393W, 394Q, 396P, 401Q, 403K, 404S, 409I, 411D, 420A, 421G, 423S, 458K
CDD
cd00433 (Peptidase_M17)

172A

interface (dimer of trimers)
45K, 46K, 59S, 68T, 83N, 169N, 171P, 172A, 173A, 217A, 219F, 248Y, 254S, 259S, 262L, 265K, 266D, 298E, 300A, 301I, 302G, 303P, 305A, 307R, 308P, 309G, 310D, 311V, 317G, 319T, 323T, 360Y, 361M, 362A, 363L, 364G, 367A, 393W, 394Q, 396P, 401Q, 403K, 404S, 409I, 411D, 420A, 421G, 423S, 458K
CDD
cd00433 (Peptidase_M17)

173A

interface (dimer of trimers)
45K, 46K, 59S, 68T, 83N, 169N, 171P, 172A, 173A, 217A, 219F, 248Y, 254S, 259S, 262L, 265K, 266D, 298E, 300A, 301I, 302G, 303P, 305A, 307R, 308P, 309G, 310D, 311V, 317G, 319T, 323T, 360Y, 361M, 362A, 363L, 364G, 367A, 393W, 394Q, 396P, 401Q, 403K, 404S, 409I, 411D, 420A, 421G, 423S, 458K
CDD
cd00433 (Peptidase_M17)

217A

interface (dimer of trimers)
45K, 46K, 59S, 68T, 83N, 169N, 171P, 172A, 173A, 217A, 219F, 248Y, 254S, 259S, 262L, 265K, 266D, 298E, 300A, 301I, 302G, 303P, 305A, 307R, 308P, 309G, 310D, 311V, 317G, 319T, 323T, 360Y, 361M, 362A, 363L, 364G, 367A, 393W, 394Q, 396P, 401Q, 403K, 404S, 409I, 411D, 420A, 421G, 423S, 458K
CDD
cd00433 (Peptidase_M17)

219F

interface (dimer of trimers)
45K, 46K, 59S, 68T, 83N, 169N, 171P, 172A, 173A, 217A, 219F, 248Y, 254S, 259S, 262L, 265K, 266D, 298E, 300A, 301I, 302G, 303P, 305A, 307R, 308P, 309G, 310D, 311V, 317G, 319T, 323T, 360Y, 361M, 362A, 363L, 364G, 367A, 393W, 394Q, 396P, 401Q, 403K, 404S, 409I, 411D, 420A, 421G, 423S, 458K
CDD
cd00433 (Peptidase_M17)

248Y

interface (dimer of trimers)
45K, 46K, 59S, 68T, 83N, 169N, 171P, 172A, 173A, 217A, 219F, 248Y, 254S, 259S, 262L, 265K, 266D, 298E, 300A, 301I, 302G, 303P, 305A, 307R, 308P, 309G, 310D, 311V, 317G, 319T, 323T, 360Y, 361M, 362A, 363L, 364G, 367A, 393W, 394Q, 396P, 401Q, 403K, 404S, 409I, 411D, 420A, 421G, 423S, 458K
CDD
cd00433 (Peptidase_M17)

254S

interface (dimer of trimers)
45K, 46K, 59S, 68T, 83N, 169N, 171P, 172A, 173A, 217A, 219F, 248Y, 254S, 259S, 262L, 265K, 266D, 298E, 300A, 301I, 302G, 303P, 305A, 307R, 308P, 309G, 310D, 311V, 317G, 319T, 323T, 360Y, 361M, 362A, 363L, 364G, 367A, 393W, 394Q, 396P, 401Q, 403K, 404S, 409I, 411D, 420A, 421G, 423S, 458K
CDD
cd00433 (Peptidase_M17)

259S

interface (dimer of trimers)
45K, 46K, 59S, 68T, 83N, 169N, 171P, 172A, 173A, 217A, 219F, 248Y, 254S, 259S, 262L, 265K, 266D, 298E, 300A, 301I, 302G, 303P, 305A, 307R, 308P, 309G, 310D, 311V, 317G, 319T, 323T, 360Y, 361M, 362A, 363L, 364G, 367A, 393W, 394Q, 396P, 401Q, 403K, 404S, 409I, 411D, 420A, 421G, 423S, 458K
CDD
cd00433 (Peptidase_M17)

262L

interface (dimer of trimers)
45K, 46K, 59S, 68T, 83N, 169N, 171P, 172A, 173A, 217A, 219F, 248Y, 254S, 259S, 262L, 265K, 266D, 298E, 300A, 301I, 302G, 303P, 305A, 307R, 308P, 309G, 310D, 311V, 317G, 319T, 323T, 360Y, 361M, 362A, 363L, 364G, 367A, 393W, 394Q, 396P, 401Q, 403K, 404S, 409I, 411D, 420A, 421G, 423S, 458K
CDD
cd00433 (Peptidase_M17)

265K

interface (dimer of trimers)
45K, 46K, 59S, 68T, 83N, 169N, 171P, 172A, 173A, 217A, 219F, 248Y, 254S, 259S, 262L, 265K, 266D, 298E, 300A, 301I, 302G, 303P, 305A, 307R, 308P, 309G, 310D, 311V, 317G, 319T, 323T, 360Y, 361M, 362A, 363L, 364G, 367A, 393W, 394Q, 396P, 401Q, 403K, 404S, 409I, 411D, 420A, 421G, 423S, 458K
CDD
cd00433 (Peptidase_M17)

266D

interface (dimer of trimers)
45K, 46K, 59S, 68T, 83N, 169N, 171P, 172A, 173A, 217A, 219F, 248Y, 254S, 259S, 262L, 265K, 266D, 298E, 300A, 301I, 302G, 303P, 305A, 307R, 308P, 309G, 310D, 311V, 317G, 319T, 323T, 360Y, 361M, 362A, 363L, 364G, 367A, 393W, 394Q, 396P, 401Q, 403K, 404S, 409I, 411D, 420A, 421G, 423S, 458K
CDD
cd00433 (Peptidase_M17)

298E

interface (dimer of trimers)
45K, 46K, 59S, 68T, 83N, 169N, 171P, 172A, 173A, 217A, 219F, 248Y, 254S, 259S, 262L, 265K, 266D, 298E, 300A, 301I, 302G, 303P, 305A, 307R, 308P, 309G, 310D, 311V, 317G, 319T, 323T, 360Y, 361M, 362A, 363L, 364G, 367A, 393W, 394Q, 396P, 401Q, 403K, 404S, 409I, 411D, 420A, 421G, 423S, 458K
CDD
cd00433 (Peptidase_M17)

300A

interface (dimer of trimers)
45K, 46K, 59S, 68T, 83N, 169N, 171P, 172A, 173A, 217A, 219F, 248Y, 254S, 259S, 262L, 265K, 266D, 298E, 300A, 301I, 302G, 303P, 305A, 307R, 308P, 309G, 310D, 311V, 317G, 319T, 323T, 360Y, 361M, 362A, 363L, 364G, 367A, 393W, 394Q, 396P, 401Q, 403K, 404S, 409I, 411D, 420A, 421G, 423S, 458K
CDD
cd00433 (Peptidase_M17)

301I

interface (dimer of trimers)
45K, 46K, 59S, 68T, 83N, 169N, 171P, 172A, 173A, 217A, 219F, 248Y, 254S, 259S, 262L, 265K, 266D, 298E, 300A, 301I, 302G, 303P, 305A, 307R, 308P, 309G, 310D, 311V, 317G, 319T, 323T, 360Y, 361M, 362A, 363L, 364G, 367A, 393W, 394Q, 396P, 401Q, 403K, 404S, 409I, 411D, 420A, 421G, 423S, 458K
CDD
cd00433 (Peptidase_M17)

302G

interface (dimer of trimers)
45K, 46K, 59S, 68T, 83N, 169N, 171P, 172A, 173A, 217A, 219F, 248Y, 254S, 259S, 262L, 265K, 266D, 298E, 300A, 301I, 302G, 303P, 305A, 307R, 308P, 309G, 310D, 311V, 317G, 319T, 323T, 360Y, 361M, 362A, 363L, 364G, 367A, 393W, 394Q, 396P, 401Q, 403K, 404S, 409I, 411D, 420A, 421G, 423S, 458K
CDD
cd00433 (Peptidase_M17)

303P

interface (dimer of trimers)
45K, 46K, 59S, 68T, 83N, 169N, 171P, 172A, 173A, 217A, 219F, 248Y, 254S, 259S, 262L, 265K, 266D, 298E, 300A, 301I, 302G, 303P, 305A, 307R, 308P, 309G, 310D, 311V, 317G, 319T, 323T, 360Y, 361M, 362A, 363L, 364G, 367A, 393W, 394Q, 396P, 401Q, 403K, 404S, 409I, 411D, 420A, 421G, 423S, 458K
CDD
cd00433 (Peptidase_M17)

305A

interface (dimer of trimers)
45K, 46K, 59S, 68T, 83N, 169N, 171P, 172A, 173A, 217A, 219F, 248Y, 254S, 259S, 262L, 265K, 266D, 298E, 300A, 301I, 302G, 303P, 305A, 307R, 308P, 309G, 310D, 311V, 317G, 319T, 323T, 360Y, 361M, 362A, 363L, 364G, 367A, 393W, 394Q, 396P, 401Q, 403K, 404S, 409I, 411D, 420A, 421G, 423S, 458K
CDD
cd00433 (Peptidase_M17)

307R

interface (dimer of trimers)
45K, 46K, 59S, 68T, 83N, 169N, 171P, 172A, 173A, 217A, 219F, 248Y, 254S, 259S, 262L, 265K, 266D, 298E, 300A, 301I, 302G, 303P, 305A, 307R, 308P, 309G, 310D, 311V, 317G, 319T, 323T, 360Y, 361M, 362A, 363L, 364G, 367A, 393W, 394Q, 396P, 401Q, 403K, 404S, 409I, 411D, 420A, 421G, 423S, 458K
CDD
cd00433 (Peptidase_M17)

308P

interface (dimer of trimers)
45K, 46K, 59S, 68T, 83N, 169N, 171P, 172A, 173A, 217A, 219F, 248Y, 254S, 259S, 262L, 265K, 266D, 298E, 300A, 301I, 302G, 303P, 305A, 307R, 308P, 309G, 310D, 311V, 317G, 319T, 323T, 360Y, 361M, 362A, 363L, 364G, 367A, 393W, 394Q, 396P, 401Q, 403K, 404S, 409I, 411D, 420A, 421G, 423S, 458K
CDD
cd00433 (Peptidase_M17)

309G

interface (dimer of trimers)
45K, 46K, 59S, 68T, 83N, 169N, 171P, 172A, 173A, 217A, 219F, 248Y, 254S, 259S, 262L, 265K, 266D, 298E, 300A, 301I, 302G, 303P, 305A, 307R, 308P, 309G, 310D, 311V, 317G, 319T, 323T, 360Y, 361M, 362A, 363L, 364G, 367A, 393W, 394Q, 396P, 401Q, 403K, 404S, 409I, 411D, 420A, 421G, 423S, 458K
CDD
cd00433 (Peptidase_M17)

310D

interface (dimer of trimers)
45K, 46K, 59S, 68T, 83N, 169N, 171P, 172A, 173A, 217A, 219F, 248Y, 254S, 259S, 262L, 265K, 266D, 298E, 300A, 301I, 302G, 303P, 305A, 307R, 308P, 309G, 310D, 311V, 317G, 319T, 323T, 360Y, 361M, 362A, 363L, 364G, 367A, 393W, 394Q, 396P, 401Q, 403K, 404S, 409I, 411D, 420A, 421G, 423S, 458K
CDD
cd00433 (Peptidase_M17)

311V

interface (dimer of trimers)
45K, 46K, 59S, 68T, 83N, 169N, 171P, 172A, 173A, 217A, 219F, 248Y, 254S, 259S, 262L, 265K, 266D, 298E, 300A, 301I, 302G, 303P, 305A, 307R, 308P, 309G, 310D, 311V, 317G, 319T, 323T, 360Y, 361M, 362A, 363L, 364G, 367A, 393W, 394Q, 396P, 401Q, 403K, 404S, 409I, 411D, 420A, 421G, 423S, 458K
CDD
cd00433 (Peptidase_M17)

317G

interface (dimer of trimers)
45K, 46K, 59S, 68T, 83N, 169N, 171P, 172A, 173A, 217A, 219F, 248Y, 254S, 259S, 262L, 265K, 266D, 298E, 300A, 301I, 302G, 303P, 305A, 307R, 308P, 309G, 310D, 311V, 317G, 319T, 323T, 360Y, 361M, 362A, 363L, 364G, 367A, 393W, 394Q, 396P, 401Q, 403K, 404S, 409I, 411D, 420A, 421G, 423S, 458K
CDD
cd00433 (Peptidase_M17)

319T

interface (dimer of trimers)
45K, 46K, 59S, 68T, 83N, 169N, 171P, 172A, 173A, 217A, 219F, 248Y, 254S, 259S, 262L, 265K, 266D, 298E, 300A, 301I, 302G, 303P, 305A, 307R, 308P, 309G, 310D, 311V, 317G, 319T, 323T, 360Y, 361M, 362A, 363L, 364G, 367A, 393W, 394Q, 396P, 401Q, 403K, 404S, 409I, 411D, 420A, 421G, 423S, 458K
CDD
cd00433 (Peptidase_M17)

323T

interface (dimer of trimers)
45K, 46K, 59S, 68T, 83N, 169N, 171P, 172A, 173A, 217A, 219F, 248Y, 254S, 259S, 262L, 265K, 266D, 298E, 300A, 301I, 302G, 303P, 305A, 307R, 308P, 309G, 310D, 311V, 317G, 319T, 323T, 360Y, 361M, 362A, 363L, 364G, 367A, 393W, 394Q, 396P, 401Q, 403K, 404S, 409I, 411D, 420A, 421G, 423S, 458K
CDD
cd00433 (Peptidase_M17)

360Y

interface (dimer of trimers)
45K, 46K, 59S, 68T, 83N, 169N, 171P, 172A, 173A, 217A, 219F, 248Y, 254S, 259S, 262L, 265K, 266D, 298E, 300A, 301I, 302G, 303P, 305A, 307R, 308P, 309G, 310D, 311V, 317G, 319T, 323T, 360Y, 361M, 362A, 363L, 364G, 367A, 393W, 394Q, 396P, 401Q, 403K, 404S, 409I, 411D, 420A, 421G, 423S, 458K
CDD
cd00433 (Peptidase_M17)

361M

interface (dimer of trimers)
45K, 46K, 59S, 68T, 83N, 169N, 171P, 172A, 173A, 217A, 219F, 248Y, 254S, 259S, 262L, 265K, 266D, 298E, 300A, 301I, 302G, 303P, 305A, 307R, 308P, 309G, 310D, 311V, 317G, 319T, 323T, 360Y, 361M, 362A, 363L, 364G, 367A, 393W, 394Q, 396P, 401Q, 403K, 404S, 409I, 411D, 420A, 421G, 423S, 458K
CDD
cd00433 (Peptidase_M17)

362A

interface (dimer of trimers)
45K, 46K, 59S, 68T, 83N, 169N, 171P, 172A, 173A, 217A, 219F, 248Y, 254S, 259S, 262L, 265K, 266D, 298E, 300A, 301I, 302G, 303P, 305A, 307R, 308P, 309G, 310D, 311V, 317G, 319T, 323T, 360Y, 361M, 362A, 363L, 364G, 367A, 393W, 394Q, 396P, 401Q, 403K, 404S, 409I, 411D, 420A, 421G, 423S, 458K
CDD
cd00433 (Peptidase_M17)

363L

interface (dimer of trimers)
45K, 46K, 59S, 68T, 83N, 169N, 171P, 172A, 173A, 217A, 219F, 248Y, 254S, 259S, 262L, 265K, 266D, 298E, 300A, 301I, 302G, 303P, 305A, 307R, 308P, 309G, 310D, 311V, 317G, 319T, 323T, 360Y, 361M, 362A, 363L, 364G, 367A, 393W, 394Q, 396P, 401Q, 403K, 404S, 409I, 411D, 420A, 421G, 423S, 458K
CDD
cd00433 (Peptidase_M17)

364G

interface (dimer of trimers)
45K, 46K, 59S, 68T, 83N, 169N, 171P, 172A, 173A, 217A, 219F, 248Y, 254S, 259S, 262L, 265K, 266D, 298E, 300A, 301I, 302G, 303P, 305A, 307R, 308P, 309G, 310D, 311V, 317G, 319T, 323T, 360Y, 361M, 362A, 363L, 364G, 367A, 393W, 394Q, 396P, 401Q, 403K, 404S, 409I, 411D, 420A, 421G, 423S, 458K
CDD
cd00433 (Peptidase_M17)

367A

interface (dimer of trimers)
45K, 46K, 59S, 68T, 83N, 169N, 171P, 172A, 173A, 217A, 219F, 248Y, 254S, 259S, 262L, 265K, 266D, 298E, 300A, 301I, 302G, 303P, 305A, 307R, 308P, 309G, 310D, 311V, 317G, 319T, 323T, 360Y, 361M, 362A, 363L, 364G, 367A, 393W, 394Q, 396P, 401Q, 403K, 404S, 409I, 411D, 420A, 421G, 423S, 458K
CDD
cd00433 (Peptidase_M17)

393W

interface (dimer of trimers)
45K, 46K, 59S, 68T, 83N, 169N, 171P, 172A, 173A, 217A, 219F, 248Y, 254S, 259S, 262L, 265K, 266D, 298E, 300A, 301I, 302G, 303P, 305A, 307R, 308P, 309G, 310D, 311V, 317G, 319T, 323T, 360Y, 361M, 362A, 363L, 364G, 367A, 393W, 394Q, 396P, 401Q, 403K, 404S, 409I, 411D, 420A, 421G, 423S, 458K
CDD
cd00433 (Peptidase_M17)

394Q

interface (dimer of trimers)
45K, 46K, 59S, 68T, 83N, 169N, 171P, 172A, 173A, 217A, 219F, 248Y, 254S, 259S, 262L, 265K, 266D, 298E, 300A, 301I, 302G, 303P, 305A, 307R, 308P, 309G, 310D, 311V, 317G, 319T, 323T, 360Y, 361M, 362A, 363L, 364G, 367A, 393W, 394Q, 396P, 401Q, 403K, 404S, 409I, 411D, 420A, 421G, 423S, 458K
CDD
cd00433 (Peptidase_M17)

396P

interface (dimer of trimers)
45K, 46K, 59S, 68T, 83N, 169N, 171P, 172A, 173A, 217A, 219F, 248Y, 254S, 259S, 262L, 265K, 266D, 298E, 300A, 301I, 302G, 303P, 305A, 307R, 308P, 309G, 310D, 311V, 317G, 319T, 323T, 360Y, 361M, 362A, 363L, 364G, 367A, 393W, 394Q, 396P, 401Q, 403K, 404S, 409I, 411D, 420A, 421G, 423S, 458K
CDD
cd00433 (Peptidase_M17)

401Q

interface (dimer of trimers)
45K, 46K, 59S, 68T, 83N, 169N, 171P, 172A, 173A, 217A, 219F, 248Y, 254S, 259S, 262L, 265K, 266D, 298E, 300A, 301I, 302G, 303P, 305A, 307R, 308P, 309G, 310D, 311V, 317G, 319T, 323T, 360Y, 361M, 362A, 363L, 364G, 367A, 393W, 394Q, 396P, 401Q, 403K, 404S, 409I, 411D, 420A, 421G, 423S, 458K
CDD
cd00433 (Peptidase_M17)

403K

interface (dimer of trimers)
45K, 46K, 59S, 68T, 83N, 169N, 171P, 172A, 173A, 217A, 219F, 248Y, 254S, 259S, 262L, 265K, 266D, 298E, 300A, 301I, 302G, 303P, 305A, 307R, 308P, 309G, 310D, 311V, 317G, 319T, 323T, 360Y, 361M, 362A, 363L, 364G, 367A, 393W, 394Q, 396P, 401Q, 403K, 404S, 409I, 411D, 420A, 421G, 423S, 458K
CDD
cd00433 (Peptidase_M17)

404S

interface (dimer of trimers)
45K, 46K, 59S, 68T, 83N, 169N, 171P, 172A, 173A, 217A, 219F, 248Y, 254S, 259S, 262L, 265K, 266D, 298E, 300A, 301I, 302G, 303P, 305A, 307R, 308P, 309G, 310D, 311V, 317G, 319T, 323T, 360Y, 361M, 362A, 363L, 364G, 367A, 393W, 394Q, 396P, 401Q, 403K, 404S, 409I, 411D, 420A, 421G, 423S, 458K
CDD
cd00433 (Peptidase_M17)

409I

interface (dimer of trimers)
45K, 46K, 59S, 68T, 83N, 169N, 171P, 172A, 173A, 217A, 219F, 248Y, 254S, 259S, 262L, 265K, 266D, 298E, 300A, 301I, 302G, 303P, 305A, 307R, 308P, 309G, 310D, 311V, 317G, 319T, 323T, 360Y, 361M, 362A, 363L, 364G, 367A, 393W, 394Q, 396P, 401Q, 403K, 404S, 409I, 411D, 420A, 421G, 423S, 458K
CDD
cd00433 (Peptidase_M17)

411D

interface (dimer of trimers)
45K, 46K, 59S, 68T, 83N, 169N, 171P, 172A, 173A, 217A, 219F, 248Y, 254S, 259S, 262L, 265K, 266D, 298E, 300A, 301I, 302G, 303P, 305A, 307R, 308P, 309G, 310D, 311V, 317G, 319T, 323T, 360Y, 361M, 362A, 363L, 364G, 367A, 393W, 394Q, 396P, 401Q, 403K, 404S, 409I, 411D, 420A, 421G, 423S, 458K
CDD
cd00433 (Peptidase_M17)

420A

interface (dimer of trimers)
45K, 46K, 59S, 68T, 83N, 169N, 171P, 172A, 173A, 217A, 219F, 248Y, 254S, 259S, 262L, 265K, 266D, 298E, 300A, 301I, 302G, 303P, 305A, 307R, 308P, 309G, 310D, 311V, 317G, 319T, 323T, 360Y, 361M, 362A, 363L, 364G, 367A, 393W, 394Q, 396P, 401Q, 403K, 404S, 409I, 411D, 420A, 421G, 423S, 458K
CDD
cd00433 (Peptidase_M17)

421G

interface (dimer of trimers)
45K, 46K, 59S, 68T, 83N, 169N, 171P, 172A, 173A, 217A, 219F, 248Y, 254S, 259S, 262L, 265K, 266D, 298E, 300A, 301I, 302G, 303P, 305A, 307R, 308P, 309G, 310D, 311V, 317G, 319T, 323T, 360Y, 361M, 362A, 363L, 364G, 367A, 393W, 394Q, 396P, 401Q, 403K, 404S, 409I, 411D, 420A, 421G, 423S, 458K
CDD
cd00433 (Peptidase_M17)

423S

interface (dimer of trimers)
45K, 46K, 59S, 68T, 83N, 169N, 171P, 172A, 173A, 217A, 219F, 248Y, 254S, 259S, 262L, 265K, 266D, 298E, 300A, 301I, 302G, 303P, 305A, 307R, 308P, 309G, 310D, 311V, 317G, 319T, 323T, 360Y, 361M, 362A, 363L, 364G, 367A, 393W, 394Q, 396P, 401Q, 403K, 404S, 409I, 411D, 420A, 421G, 423S, 458K
CDD
cd00433 (Peptidase_M17)

458K

interface (dimer of trimers)
45K, 46K, 59S, 68T, 83N, 169N, 171P, 172A, 173A, 217A, 219F, 248Y, 254S, 259S, 262L, 265K, 266D, 298E, 300A, 301I, 302G, 303P, 305A, 307R, 308P, 309G, 310D, 311V, 317G, 319T, 323T, 360Y, 361M, 362A, 363L, 364G, 367A, 393W, 394Q, 396P, 401Q, 403K, 404S, 409I, 411D, 420A, 421G, 423S, 458K
CDD
cd00433 (Peptidase_M17)
Zn-binding sites c...

244K

Zn-binding sites
244K, 249D, 267D, 326D, 328E
CDD
cd00433 (Peptidase_M17)

249D

Zn-binding sites
244K, 249D, 267D, 326D, 328E
CDD
cd00433 (Peptidase_M17)

267D

Zn-binding sites
244K, 249D, 267D, 326D, 328E
CDD
cd00433 (Peptidase_M17)

326D

Zn-binding sites
244K, 249D, 267D, 326D, 328E
CDD
cd00433 (Peptidase_M17)

328E

Zn-binding sites
244K, 249D, 267D, 326D, 328E
CDD
cd00433 (Peptidase_M17)
Substrate-binding/...

244K

Substrate-binding/catalytic site
244K, 249D, 256K, 267D, 326D, 328E, 330R, 355L
CDD
cd00433 (Peptidase_M17)

249D

Substrate-binding/catalytic site
244K, 249D, 256K, 267D, 326D, 328E, 330R, 355L
CDD
cd00433 (Peptidase_M17)

256K

Substrate-binding/catalytic site
244K, 249D, 256K, 267D, 326D, 328E, 330R, 355L
CDD
cd00433 (Peptidase_M17)

267D

Substrate-binding/catalytic site
244K, 249D, 256K, 267D, 326D, 328E, 330R, 355L
CDD
cd00433 (Peptidase_M17)

326D

Substrate-binding/catalytic site
244K, 249D, 256K, 267D, 326D, 328E, 330R, 355L
CDD
cd00433 (Peptidase_M17)

328E

Substrate-binding/catalytic site
244K, 249D, 256K, 267D, 326D, 328E, 330R, 355L
CDD
cd00433 (Peptidase_M17)

330R

Substrate-binding/catalytic site
244K, 249D, 256K, 267D, 326D, 328E, 330R, 355L
CDD
cd00433 (Peptidase_M17)

355L

Substrate-binding/catalytic site
244K, 249D, 256K, 267D, 326D, 328E, 330R, 355L
CDD
cd00433 (Peptidase_M17)

GO term prediction

Biological Process

GO:0006508 proteolysis
GO:0019538 protein metabolic process

Molecular Function

GO:0004177 aminopeptidase activity
GO:0008235 metalloexopeptidase activity
GO:0030145 manganese ion binding

Cellular Component

GO:0005622 intracellular
GO:0005737 cytoplasm