25563_FusoPortal_Gene_88

Protein

25563_FusoPortal_Gene_88

Length

500 amino acids

Protein family membership

ATP synthase, F1 complex, alpha subunit (IPR005294)

Homologous superfamilies

Homologous superfamily
3 - 82
ATP synthase subunit alpha-like domain superfamily (IPR023366)
Homologous superfamily
10 - 94
ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain superfamily (IPR036121)
96 - 370
P-loop containing nucleoside triphosphate hydrolase (IPR027417)

1 50 100 150 200 250 300 350 400 450 500 500

Domains and repeats

Domain
25 - 92
ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain (IPR004100)
94 - 367
ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain (IPR000194)
ATP synthase, F1 complex, alpha subunit nucleotide-binding domain (IPR033732)
371 - 495
ATP synthase, alpha subunit, C-terminal (IPR000793)

1 50 100 150 200 250 300 350 400 450 500 500

Detailed signature matches

IPR023366

ATP synthase subunit alpha-like domain superfamily
1. G3DSA:2.40.30.20
  
  3 - 82
  
  GENE3D
  G3DSA:2.40.30.20 (G3DSA:2.40.30.20)
IPR036121

ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain superfamily
1. SSF50615 (N-termina...)
  
  10 - 94
  
  SUPERFAMILY
  SSF50615 (N-terminal domain of alpha and beta subunits of F1 ATP synthase)
IPR027417

P-loop containing nucleoside triphosphate hydrolase
1. SSF52540 (P-loop co...)
  
  96 - 370
  
  SUPERFAMILY
  SSF52540 (P-loop containing nucleoside triphosphate hydrolases)
IPR005294

ATP synthase, F1 complex, alpha subunit
1. MF_01346 (ATP_synth...)
  
  1 - 500
  
  HAMAP
  MF_01346 (ATP_synth_alpha_bact)
2. PIRSF039088 (F_ATPa...)
  
  1 - 500
  
  PIRSF
  PIRSF039088 (F_ATPase_subunit_alpha)
3. TIGR00962
  
  3 - 499
  
  TIGRFAMs
  TIGR00962 (TIGR00962)
IPR004100

ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain
1. PF02874 (ATP-synt_ab_N)
  
  25 - 92
  
  Pfam
  PF02874 (ATP-synt_ab_N)
IPR000194

ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain
1. PF00006 (ATP-synt_ab)
  
  149 - 364
  
  Pfam
  PF00006 (ATP-synt_ab)
IPR033732

ATP synthase, F1 complex, alpha subunit nucleotide-binding domain
1. cd01132 (F1_ATPase_...)
  
  94 - 367
  
  CDD
  cd01132 (F1_ATPase_alpha)
IPR000793

ATP synthase, alpha subunit, C-terminal
1. PF00306 (ATP-synt_ab_C)
  
  371 - 495
  
  Pfam
  PF00306 (ATP-synt_ab_C)
IPR020003

ATPase, alpha/beta subunit, nucleotide-binding domain, active site
1. PS00152 (ATPASE_ALP...)
  
  355 - 364
  
  PROSITE patterns
  PS00152 (ATPASE_ALPHA_BETA)

no IPR

Unintegrated signatures

Coil

474 - 494

COILS
Coil (Coil)

372 - 392

COILS
Coil (Coil)
G3DSA:1.20.15...

373 - 499

GENE3D
G3DSA:1.20.150.20 (G3DSA:1.20.150.20)
G3DSA:3.40.50...

83 - 364

GENE3D
G3DSA:3.40.50.300 (G3DSA:3.40.50.300)
PTHR42875 (FAMILY N...)

2 - 499

PANTHER
PTHR42875 (FAMILY NOT NAMED)
SSF47917 (C-termina...)

372 - 499

SUPERFAMILY
SSF47917 (C-terminal domain of alpha and beta subunits of F1 ATP synthase)

Residue annotation

beta subunit inter...

115I

beta subunit interaction interface
115I, 116D, 132K, 133A, 135G, 136I, 139R, 141P, 171R, 172Q, 201K, 202R, 203S, 204T, 206A, 207Q, 210Q, 271R, 272E, 278R, 279R, 280P, 282G, 283R, 288G, 292Y, 295S, 299E, 336S, 339D, 350N, 351S, 354R, 365R
CDD
cd01132 (F1_ATPase_alpha)

116D

beta subunit interaction interface
115I, 116D, 132K, 133A, 135G, 136I, 139R, 141P, 171R, 172Q, 201K, 202R, 203S, 204T, 206A, 207Q, 210Q, 271R, 272E, 278R, 279R, 280P, 282G, 283R, 288G, 292Y, 295S, 299E, 336S, 339D, 350N, 351S, 354R, 365R
CDD
cd01132 (F1_ATPase_alpha)

132K

beta subunit interaction interface
115I, 116D, 132K, 133A, 135G, 136I, 139R, 141P, 171R, 172Q, 201K, 202R, 203S, 204T, 206A, 207Q, 210Q, 271R, 272E, 278R, 279R, 280P, 282G, 283R, 288G, 292Y, 295S, 299E, 336S, 339D, 350N, 351S, 354R, 365R
CDD
cd01132 (F1_ATPase_alpha)

133A

beta subunit interaction interface
115I, 116D, 132K, 133A, 135G, 136I, 139R, 141P, 171R, 172Q, 201K, 202R, 203S, 204T, 206A, 207Q, 210Q, 271R, 272E, 278R, 279R, 280P, 282G, 283R, 288G, 292Y, 295S, 299E, 336S, 339D, 350N, 351S, 354R, 365R
CDD
cd01132 (F1_ATPase_alpha)

135G

beta subunit interaction interface
115I, 116D, 132K, 133A, 135G, 136I, 139R, 141P, 171R, 172Q, 201K, 202R, 203S, 204T, 206A, 207Q, 210Q, 271R, 272E, 278R, 279R, 280P, 282G, 283R, 288G, 292Y, 295S, 299E, 336S, 339D, 350N, 351S, 354R, 365R
CDD
cd01132 (F1_ATPase_alpha)

136I

beta subunit interaction interface
115I, 116D, 132K, 133A, 135G, 136I, 139R, 141P, 171R, 172Q, 201K, 202R, 203S, 204T, 206A, 207Q, 210Q, 271R, 272E, 278R, 279R, 280P, 282G, 283R, 288G, 292Y, 295S, 299E, 336S, 339D, 350N, 351S, 354R, 365R
CDD
cd01132 (F1_ATPase_alpha)

139R

beta subunit interaction interface
115I, 116D, 132K, 133A, 135G, 136I, 139R, 141P, 171R, 172Q, 201K, 202R, 203S, 204T, 206A, 207Q, 210Q, 271R, 272E, 278R, 279R, 280P, 282G, 283R, 288G, 292Y, 295S, 299E, 336S, 339D, 350N, 351S, 354R, 365R
CDD
cd01132 (F1_ATPase_alpha)

141P

beta subunit interaction interface
115I, 116D, 132K, 133A, 135G, 136I, 139R, 141P, 171R, 172Q, 201K, 202R, 203S, 204T, 206A, 207Q, 210Q, 271R, 272E, 278R, 279R, 280P, 282G, 283R, 288G, 292Y, 295S, 299E, 336S, 339D, 350N, 351S, 354R, 365R
CDD
cd01132 (F1_ATPase_alpha)

171R

beta subunit interaction interface
115I, 116D, 132K, 133A, 135G, 136I, 139R, 141P, 171R, 172Q, 201K, 202R, 203S, 204T, 206A, 207Q, 210Q, 271R, 272E, 278R, 279R, 280P, 282G, 283R, 288G, 292Y, 295S, 299E, 336S, 339D, 350N, 351S, 354R, 365R
CDD
cd01132 (F1_ATPase_alpha)

172Q

beta subunit interaction interface
115I, 116D, 132K, 133A, 135G, 136I, 139R, 141P, 171R, 172Q, 201K, 202R, 203S, 204T, 206A, 207Q, 210Q, 271R, 272E, 278R, 279R, 280P, 282G, 283R, 288G, 292Y, 295S, 299E, 336S, 339D, 350N, 351S, 354R, 365R
CDD
cd01132 (F1_ATPase_alpha)

201K

beta subunit interaction interface
115I, 116D, 132K, 133A, 135G, 136I, 139R, 141P, 171R, 172Q, 201K, 202R, 203S, 204T, 206A, 207Q, 210Q, 271R, 272E, 278R, 279R, 280P, 282G, 283R, 288G, 292Y, 295S, 299E, 336S, 339D, 350N, 351S, 354R, 365R
CDD
cd01132 (F1_ATPase_alpha)

202R

beta subunit interaction interface
115I, 116D, 132K, 133A, 135G, 136I, 139R, 141P, 171R, 172Q, 201K, 202R, 203S, 204T, 206A, 207Q, 210Q, 271R, 272E, 278R, 279R, 280P, 282G, 283R, 288G, 292Y, 295S, 299E, 336S, 339D, 350N, 351S, 354R, 365R
CDD
cd01132 (F1_ATPase_alpha)

203S

beta subunit interaction interface
115I, 116D, 132K, 133A, 135G, 136I, 139R, 141P, 171R, 172Q, 201K, 202R, 203S, 204T, 206A, 207Q, 210Q, 271R, 272E, 278R, 279R, 280P, 282G, 283R, 288G, 292Y, 295S, 299E, 336S, 339D, 350N, 351S, 354R, 365R
CDD
cd01132 (F1_ATPase_alpha)

204T

beta subunit interaction interface
115I, 116D, 132K, 133A, 135G, 136I, 139R, 141P, 171R, 172Q, 201K, 202R, 203S, 204T, 206A, 207Q, 210Q, 271R, 272E, 278R, 279R, 280P, 282G, 283R, 288G, 292Y, 295S, 299E, 336S, 339D, 350N, 351S, 354R, 365R
CDD
cd01132 (F1_ATPase_alpha)

206A

beta subunit interaction interface
115I, 116D, 132K, 133A, 135G, 136I, 139R, 141P, 171R, 172Q, 201K, 202R, 203S, 204T, 206A, 207Q, 210Q, 271R, 272E, 278R, 279R, 280P, 282G, 283R, 288G, 292Y, 295S, 299E, 336S, 339D, 350N, 351S, 354R, 365R
CDD
cd01132 (F1_ATPase_alpha)

207Q

beta subunit interaction interface
115I, 116D, 132K, 133A, 135G, 136I, 139R, 141P, 171R, 172Q, 201K, 202R, 203S, 204T, 206A, 207Q, 210Q, 271R, 272E, 278R, 279R, 280P, 282G, 283R, 288G, 292Y, 295S, 299E, 336S, 339D, 350N, 351S, 354R, 365R
CDD
cd01132 (F1_ATPase_alpha)

210Q

beta subunit interaction interface
115I, 116D, 132K, 133A, 135G, 136I, 139R, 141P, 171R, 172Q, 201K, 202R, 203S, 204T, 206A, 207Q, 210Q, 271R, 272E, 278R, 279R, 280P, 282G, 283R, 288G, 292Y, 295S, 299E, 336S, 339D, 350N, 351S, 354R, 365R
CDD
cd01132 (F1_ATPase_alpha)

271R

beta subunit interaction interface
115I, 116D, 132K, 133A, 135G, 136I, 139R, 141P, 171R, 172Q, 201K, 202R, 203S, 204T, 206A, 207Q, 210Q, 271R, 272E, 278R, 279R, 280P, 282G, 283R, 288G, 292Y, 295S, 299E, 336S, 339D, 350N, 351S, 354R, 365R
CDD
cd01132 (F1_ATPase_alpha)

272E

beta subunit interaction interface
115I, 116D, 132K, 133A, 135G, 136I, 139R, 141P, 171R, 172Q, 201K, 202R, 203S, 204T, 206A, 207Q, 210Q, 271R, 272E, 278R, 279R, 280P, 282G, 283R, 288G, 292Y, 295S, 299E, 336S, 339D, 350N, 351S, 354R, 365R
CDD
cd01132 (F1_ATPase_alpha)

278R

beta subunit interaction interface
115I, 116D, 132K, 133A, 135G, 136I, 139R, 141P, 171R, 172Q, 201K, 202R, 203S, 204T, 206A, 207Q, 210Q, 271R, 272E, 278R, 279R, 280P, 282G, 283R, 288G, 292Y, 295S, 299E, 336S, 339D, 350N, 351S, 354R, 365R
CDD
cd01132 (F1_ATPase_alpha)

279R

beta subunit interaction interface
115I, 116D, 132K, 133A, 135G, 136I, 139R, 141P, 171R, 172Q, 201K, 202R, 203S, 204T, 206A, 207Q, 210Q, 271R, 272E, 278R, 279R, 280P, 282G, 283R, 288G, 292Y, 295S, 299E, 336S, 339D, 350N, 351S, 354R, 365R
CDD
cd01132 (F1_ATPase_alpha)

280P

beta subunit interaction interface
115I, 116D, 132K, 133A, 135G, 136I, 139R, 141P, 171R, 172Q, 201K, 202R, 203S, 204T, 206A, 207Q, 210Q, 271R, 272E, 278R, 279R, 280P, 282G, 283R, 288G, 292Y, 295S, 299E, 336S, 339D, 350N, 351S, 354R, 365R
CDD
cd01132 (F1_ATPase_alpha)

282G

beta subunit interaction interface
115I, 116D, 132K, 133A, 135G, 136I, 139R, 141P, 171R, 172Q, 201K, 202R, 203S, 204T, 206A, 207Q, 210Q, 271R, 272E, 278R, 279R, 280P, 282G, 283R, 288G, 292Y, 295S, 299E, 336S, 339D, 350N, 351S, 354R, 365R
CDD
cd01132 (F1_ATPase_alpha)

283R

beta subunit interaction interface
115I, 116D, 132K, 133A, 135G, 136I, 139R, 141P, 171R, 172Q, 201K, 202R, 203S, 204T, 206A, 207Q, 210Q, 271R, 272E, 278R, 279R, 280P, 282G, 283R, 288G, 292Y, 295S, 299E, 336S, 339D, 350N, 351S, 354R, 365R
CDD
cd01132 (F1_ATPase_alpha)

288G

beta subunit interaction interface
115I, 116D, 132K, 133A, 135G, 136I, 139R, 141P, 171R, 172Q, 201K, 202R, 203S, 204T, 206A, 207Q, 210Q, 271R, 272E, 278R, 279R, 280P, 282G, 283R, 288G, 292Y, 295S, 299E, 336S, 339D, 350N, 351S, 354R, 365R
CDD
cd01132 (F1_ATPase_alpha)

292Y

beta subunit interaction interface
115I, 116D, 132K, 133A, 135G, 136I, 139R, 141P, 171R, 172Q, 201K, 202R, 203S, 204T, 206A, 207Q, 210Q, 271R, 272E, 278R, 279R, 280P, 282G, 283R, 288G, 292Y, 295S, 299E, 336S, 339D, 350N, 351S, 354R, 365R
CDD
cd01132 (F1_ATPase_alpha)

295S

beta subunit interaction interface
115I, 116D, 132K, 133A, 135G, 136I, 139R, 141P, 171R, 172Q, 201K, 202R, 203S, 204T, 206A, 207Q, 210Q, 271R, 272E, 278R, 279R, 280P, 282G, 283R, 288G, 292Y, 295S, 299E, 336S, 339D, 350N, 351S, 354R, 365R
CDD
cd01132 (F1_ATPase_alpha)

299E

beta subunit interaction interface
115I, 116D, 132K, 133A, 135G, 136I, 139R, 141P, 171R, 172Q, 201K, 202R, 203S, 204T, 206A, 207Q, 210Q, 271R, 272E, 278R, 279R, 280P, 282G, 283R, 288G, 292Y, 295S, 299E, 336S, 339D, 350N, 351S, 354R, 365R
CDD
cd01132 (F1_ATPase_alpha)

336S

beta subunit interaction interface
115I, 116D, 132K, 133A, 135G, 136I, 139R, 141P, 171R, 172Q, 201K, 202R, 203S, 204T, 206A, 207Q, 210Q, 271R, 272E, 278R, 279R, 280P, 282G, 283R, 288G, 292Y, 295S, 299E, 336S, 339D, 350N, 351S, 354R, 365R
CDD
cd01132 (F1_ATPase_alpha)

339D

beta subunit interaction interface
115I, 116D, 132K, 133A, 135G, 136I, 139R, 141P, 171R, 172Q, 201K, 202R, 203S, 204T, 206A, 207Q, 210Q, 271R, 272E, 278R, 279R, 280P, 282G, 283R, 288G, 292Y, 295S, 299E, 336S, 339D, 350N, 351S, 354R, 365R
CDD
cd01132 (F1_ATPase_alpha)

350N

beta subunit interaction interface
115I, 116D, 132K, 133A, 135G, 136I, 139R, 141P, 171R, 172Q, 201K, 202R, 203S, 204T, 206A, 207Q, 210Q, 271R, 272E, 278R, 279R, 280P, 282G, 283R, 288G, 292Y, 295S, 299E, 336S, 339D, 350N, 351S, 354R, 365R
CDD
cd01132 (F1_ATPase_alpha)

351S

beta subunit interaction interface
115I, 116D, 132K, 133A, 135G, 136I, 139R, 141P, 171R, 172Q, 201K, 202R, 203S, 204T, 206A, 207Q, 210Q, 271R, 272E, 278R, 279R, 280P, 282G, 283R, 288G, 292Y, 295S, 299E, 336S, 339D, 350N, 351S, 354R, 365R
CDD
cd01132 (F1_ATPase_alpha)

354R

beta subunit interaction interface
115I, 116D, 132K, 133A, 135G, 136I, 139R, 141P, 171R, 172Q, 201K, 202R, 203S, 204T, 206A, 207Q, 210Q, 271R, 272E, 278R, 279R, 280P, 282G, 283R, 288G, 292Y, 295S, 299E, 336S, 339D, 350N, 351S, 354R, 365R
CDD
cd01132 (F1_ATPase_alpha)

365R

beta subunit interaction interface
115I, 116D, 132K, 133A, 135G, 136I, 139R, 141P, 171R, 172Q, 201K, 202R, 203S, 204T, 206A, 207Q, 210Q, 271R, 272E, 278R, 279R, 280P, 282G, 283R, 288G, 292Y, 295S, 299E, 336S, 339D, 350N, 351S, 354R, 365R
CDD
cd01132 (F1_ATPase_alpha)
Walker A motif cd0...

169G

Walker A motif
169G, 170D, 171R, 172Q, 173T, 174G, 175K, 176T
CDD
cd01132 (F1_ATPase_alpha)

170D

Walker A motif
169G, 170D, 171R, 172Q, 173T, 174G, 175K, 176T
CDD
cd01132 (F1_ATPase_alpha)

171R

Walker A motif
169G, 170D, 171R, 172Q, 173T, 174G, 175K, 176T
CDD
cd01132 (F1_ATPase_alpha)

172Q

Walker A motif
169G, 170D, 171R, 172Q, 173T, 174G, 175K, 176T
CDD
cd01132 (F1_ATPase_alpha)

173T

Walker A motif
169G, 170D, 171R, 172Q, 173T, 174G, 175K, 176T
CDD
cd01132 (F1_ATPase_alpha)

174G

Walker A motif
169G, 170D, 171R, 172Q, 173T, 174G, 175K, 176T
CDD
cd01132 (F1_ATPase_alpha)

175K

Walker A motif
169G, 170D, 171R, 172Q, 173T, 174G, 175K, 176T
CDD
cd01132 (F1_ATPase_alpha)

176T

Walker A motif
169G, 170D, 171R, 172Q, 173T, 174G, 175K, 176T
CDD
cd01132 (F1_ATPase_alpha)
ATP binding site c...

171R

ATP binding site
171R, 175K, 176T, 177A, 195Y, 200Q, 261D, 262D, 265K, 320E, 336S, 349F, 354R, 355P, 365R
CDD
cd01132 (F1_ATPase_alpha)

175K

ATP binding site
171R, 175K, 176T, 177A, 195Y, 200Q, 261D, 262D, 265K, 320E, 336S, 349F, 354R, 355P, 365R
CDD
cd01132 (F1_ATPase_alpha)

176T

ATP binding site
171R, 175K, 176T, 177A, 195Y, 200Q, 261D, 262D, 265K, 320E, 336S, 349F, 354R, 355P, 365R
CDD
cd01132 (F1_ATPase_alpha)

177A

ATP binding site
171R, 175K, 176T, 177A, 195Y, 200Q, 261D, 262D, 265K, 320E, 336S, 349F, 354R, 355P, 365R
CDD
cd01132 (F1_ATPase_alpha)

195Y

ATP binding site
171R, 175K, 176T, 177A, 195Y, 200Q, 261D, 262D, 265K, 320E, 336S, 349F, 354R, 355P, 365R
CDD
cd01132 (F1_ATPase_alpha)

200Q

ATP binding site
171R, 175K, 176T, 177A, 195Y, 200Q, 261D, 262D, 265K, 320E, 336S, 349F, 354R, 355P, 365R
CDD
cd01132 (F1_ATPase_alpha)

261D

ATP binding site
171R, 175K, 176T, 177A, 195Y, 200Q, 261D, 262D, 265K, 320E, 336S, 349F, 354R, 355P, 365R
CDD
cd01132 (F1_ATPase_alpha)

262D

ATP binding site
171R, 175K, 176T, 177A, 195Y, 200Q, 261D, 262D, 265K, 320E, 336S, 349F, 354R, 355P, 365R
CDD
cd01132 (F1_ATPase_alpha)

265K

ATP binding site
171R, 175K, 176T, 177A, 195Y, 200Q, 261D, 262D, 265K, 320E, 336S, 349F, 354R, 355P, 365R
CDD
cd01132 (F1_ATPase_alpha)

320E

ATP binding site
171R, 175K, 176T, 177A, 195Y, 200Q, 261D, 262D, 265K, 320E, 336S, 349F, 354R, 355P, 365R
CDD
cd01132 (F1_ATPase_alpha)

336S

ATP binding site
171R, 175K, 176T, 177A, 195Y, 200Q, 261D, 262D, 265K, 320E, 336S, 349F, 354R, 355P, 365R
CDD
cd01132 (F1_ATPase_alpha)

349F

ATP binding site
171R, 175K, 176T, 177A, 195Y, 200Q, 261D, 262D, 265K, 320E, 336S, 349F, 354R, 355P, 365R
CDD
cd01132 (F1_ATPase_alpha)

354R

ATP binding site
171R, 175K, 176T, 177A, 195Y, 200Q, 261D, 262D, 265K, 320E, 336S, 349F, 354R, 355P, 365R
CDD
cd01132 (F1_ATPase_alpha)

355P

ATP binding site
171R, 175K, 176T, 177A, 195Y, 200Q, 261D, 262D, 265K, 320E, 336S, 349F, 354R, 355P, 365R
CDD
cd01132 (F1_ATPase_alpha)

365R

ATP binding site
171R, 175K, 176T, 177A, 195Y, 200Q, 261D, 262D, 265K, 320E, 336S, 349F, 354R, 355P, 365R
CDD
cd01132 (F1_ATPase_alpha)
Walker B motif cd0...

257L

Walker B motif
257L, 258I, 259I, 260Y, 261D
CDD
cd01132 (F1_ATPase_alpha)

258I

Walker B motif
257L, 258I, 259I, 260Y, 261D
CDD
cd01132 (F1_ATPase_alpha)

259I

Walker B motif
257L, 258I, 259I, 260Y, 261D
CDD
cd01132 (F1_ATPase_alpha)

260Y

Walker B motif
257L, 258I, 259I, 260Y, 261D
CDD
cd01132 (F1_ATPase_alpha)

261D

Walker B motif
257L, 258I, 259I, 260Y, 261D
CDD
cd01132 (F1_ATPase_alpha)

GO term prediction

Biological Process

GO:0015986 ATP synthesis coupled proton transport
GO:0015992 proton transport
GO:0046034 ATP metabolic process

Molecular Function

GO:0005524 ATP binding
GO:0032559 adenyl ribonucleotide binding
GO:0046933 proton-transporting ATP synthase activity, rotational mechanism

Cellular Component

GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1)

Filter view on

Entry type

Status

Per-residue features

25563_FusoPortal_Gene_88

Protein family membership

Homologous superfamilies

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component