25563_FusoPortal_Gene_919

Protein

25563_FusoPortal_Gene_919

Length

471 amino acids

Protein family membership

Fumarate lyase family (IPR000362)

Homologous superfamilies

Homologous superfamily
1 - 136
Fumarase/histidase, N-terminal (IPR024083)
Homologous superfamily
3 - 458
L-Aspartase-like (IPR008948)

1 50 100 150 200 250 300 350 400 471

Domains and repeats

Domain
11 - 340
Fumarate lyase, N-terminal (IPR022761)
406 - 459
Fumarase C, C-terminal (IPR018951)

1 50 100 150 200 250 300 350 400 471

Detailed signature matches

IPR024083

Fumarase/histidase, N-terminal
1. G3DSA:1.10.27...
  
  1 - 136
  
  GENE3D
  G3DSA:1.10.275.10 (G3DSA:1.10.275.10)
IPR008948

L-Aspartase-like
1. SSF48557 (L-asparta...)
  
  3 - 458
  
  SUPERFAMILY
  SSF48557 (L-aspartase-like)
IPR000362

Fumarate lyase family
1. PR00149 (FUMRATELYASE)
  
  133 - 151
  
  PRINTS
  PR00149 (FUMRATELYASE)
  
  178 - 196
  
  PRINTS
  PR00149 (FUMRATELYASE)
  
  269 - 296
  
  PRINTS
  PR00149 (FUMRATELYASE)
  
  315 - 331
  
  PRINTS
  PR00149 (FUMRATELYASE)
IPR022761

Fumarate lyase, N-terminal
1. PF00206 (Lyase_1)
  
  11 - 340
  
  Pfam
  PF00206 (Lyase_1)
IPR018951

Fumarase C, C-terminal
1. PF10415 (FumaraseC_C)
  
  406 - 459
  
  Pfam
  PF10415 (FumaraseC_C)
IPR020557

Fumarate lyase, conserved site
1. PS00163 (FUMARATE_L...)
  
  315 - 324
  
  PROSITE patterns
  PS00163 (FUMARATE_LYASES)

no IPR

Unintegrated signatures

G3DSA:1.10.40.30

413 - 460

GENE3D
G3DSA:1.10.40.30 (G3DSA:1.10.40.30)
G3DSA:1.20.20...

137 - 412

GENE3D
G3DSA:1.20.200.10 (G3DSA:1.20.200.10)
PR00145 (ARGSUCLYASE)

173 - 193

PRINTS
PR00145 (ARGSUCLYASE)

315 - 331

PRINTS
PR00145 (ARGSUCLYASE)

132 - 154

PRINTS
PR00145 (ARGSUCLYASE)
PTHR42696 (FAMILY N...)

1 - 467

PANTHER
PTHR42696 (FAMILY NOT NAMED)
cd01357 (Aspartase)

4 - 453

CDD
cd01357 (Aspartase)

Residue annotation

active sites cd01357

96G

active sites
96G, 97A, 98G, 99T, 138S, 139T, 140N, 185T, 186H, 322K, 324N, 329E
CDD
cd01357 (Aspartase)

97A

active sites
96G, 97A, 98G, 99T, 138S, 139T, 140N, 185T, 186H, 322K, 324N, 329E
CDD
cd01357 (Aspartase)

98G

active sites
96G, 97A, 98G, 99T, 138S, 139T, 140N, 185T, 186H, 322K, 324N, 329E
CDD
cd01357 (Aspartase)

99T

active sites
96G, 97A, 98G, 99T, 138S, 139T, 140N, 185T, 186H, 322K, 324N, 329E
CDD
cd01357 (Aspartase)

138S

active sites
96G, 97A, 98G, 99T, 138S, 139T, 140N, 185T, 186H, 322K, 324N, 329E
CDD
cd01357 (Aspartase)

139T

active sites
96G, 97A, 98G, 99T, 138S, 139T, 140N, 185T, 186H, 322K, 324N, 329E
CDD
cd01357 (Aspartase)

140N

active sites
96G, 97A, 98G, 99T, 138S, 139T, 140N, 185T, 186H, 322K, 324N, 329E
CDD
cd01357 (Aspartase)

185T

active sites
96G, 97A, 98G, 99T, 138S, 139T, 140N, 185T, 186H, 322K, 324N, 329E
CDD
cd01357 (Aspartase)

186H

active sites
96G, 97A, 98G, 99T, 138S, 139T, 140N, 185T, 186H, 322K, 324N, 329E
CDD
cd01357 (Aspartase)

322K

active sites
96G, 97A, 98G, 99T, 138S, 139T, 140N, 185T, 186H, 322K, 324N, 329E
CDD
cd01357 (Aspartase)

324N

active sites
96G, 97A, 98G, 99T, 138S, 139T, 140N, 185T, 186H, 322K, 324N, 329E
CDD
cd01357 (Aspartase)

329E

active sites
96G, 97A, 98G, 99T, 138S, 139T, 140N, 185T, 186H, 322K, 324N, 329E
CDD
cd01357 (Aspartase)
tetramer interface...

184R

tetramer interface
184R, 185T, 186H, 187L, 191V, 197Q, 198E, 204G, 208R, 212R, 230V, 260E, 261D, 264D, 267R, 268N, 270D, 273V, 274Y, 277S, 280K, 281T, 284V, 285N, 287S, 288K, 291N, 292D, 342D, 350E, 353Q, 354L, 355E, 408T
CDD
cd01357 (Aspartase)

185T

tetramer interface
184R, 185T, 186H, 187L, 191V, 197Q, 198E, 204G, 208R, 212R, 230V, 260E, 261D, 264D, 267R, 268N, 270D, 273V, 274Y, 277S, 280K, 281T, 284V, 285N, 287S, 288K, 291N, 292D, 342D, 350E, 353Q, 354L, 355E, 408T
CDD
cd01357 (Aspartase)

186H

tetramer interface
184R, 185T, 186H, 187L, 191V, 197Q, 198E, 204G, 208R, 212R, 230V, 260E, 261D, 264D, 267R, 268N, 270D, 273V, 274Y, 277S, 280K, 281T, 284V, 285N, 287S, 288K, 291N, 292D, 342D, 350E, 353Q, 354L, 355E, 408T
CDD
cd01357 (Aspartase)

187L

tetramer interface
184R, 185T, 186H, 187L, 191V, 197Q, 198E, 204G, 208R, 212R, 230V, 260E, 261D, 264D, 267R, 268N, 270D, 273V, 274Y, 277S, 280K, 281T, 284V, 285N, 287S, 288K, 291N, 292D, 342D, 350E, 353Q, 354L, 355E, 408T
CDD
cd01357 (Aspartase)

191V

tetramer interface
184R, 185T, 186H, 187L, 191V, 197Q, 198E, 204G, 208R, 212R, 230V, 260E, 261D, 264D, 267R, 268N, 270D, 273V, 274Y, 277S, 280K, 281T, 284V, 285N, 287S, 288K, 291N, 292D, 342D, 350E, 353Q, 354L, 355E, 408T
CDD
cd01357 (Aspartase)

197Q

tetramer interface
184R, 185T, 186H, 187L, 191V, 197Q, 198E, 204G, 208R, 212R, 230V, 260E, 261D, 264D, 267R, 268N, 270D, 273V, 274Y, 277S, 280K, 281T, 284V, 285N, 287S, 288K, 291N, 292D, 342D, 350E, 353Q, 354L, 355E, 408T
CDD
cd01357 (Aspartase)

198E

tetramer interface
184R, 185T, 186H, 187L, 191V, 197Q, 198E, 204G, 208R, 212R, 230V, 260E, 261D, 264D, 267R, 268N, 270D, 273V, 274Y, 277S, 280K, 281T, 284V, 285N, 287S, 288K, 291N, 292D, 342D, 350E, 353Q, 354L, 355E, 408T
CDD
cd01357 (Aspartase)

204G

tetramer interface
184R, 185T, 186H, 187L, 191V, 197Q, 198E, 204G, 208R, 212R, 230V, 260E, 261D, 264D, 267R, 268N, 270D, 273V, 274Y, 277S, 280K, 281T, 284V, 285N, 287S, 288K, 291N, 292D, 342D, 350E, 353Q, 354L, 355E, 408T
CDD
cd01357 (Aspartase)

208R

tetramer interface
184R, 185T, 186H, 187L, 191V, 197Q, 198E, 204G, 208R, 212R, 230V, 260E, 261D, 264D, 267R, 268N, 270D, 273V, 274Y, 277S, 280K, 281T, 284V, 285N, 287S, 288K, 291N, 292D, 342D, 350E, 353Q, 354L, 355E, 408T
CDD
cd01357 (Aspartase)

212R

tetramer interface
184R, 185T, 186H, 187L, 191V, 197Q, 198E, 204G, 208R, 212R, 230V, 260E, 261D, 264D, 267R, 268N, 270D, 273V, 274Y, 277S, 280K, 281T, 284V, 285N, 287S, 288K, 291N, 292D, 342D, 350E, 353Q, 354L, 355E, 408T
CDD
cd01357 (Aspartase)

230V

tetramer interface
184R, 185T, 186H, 187L, 191V, 197Q, 198E, 204G, 208R, 212R, 230V, 260E, 261D, 264D, 267R, 268N, 270D, 273V, 274Y, 277S, 280K, 281T, 284V, 285N, 287S, 288K, 291N, 292D, 342D, 350E, 353Q, 354L, 355E, 408T
CDD
cd01357 (Aspartase)

260E

tetramer interface
184R, 185T, 186H, 187L, 191V, 197Q, 198E, 204G, 208R, 212R, 230V, 260E, 261D, 264D, 267R, 268N, 270D, 273V, 274Y, 277S, 280K, 281T, 284V, 285N, 287S, 288K, 291N, 292D, 342D, 350E, 353Q, 354L, 355E, 408T
CDD
cd01357 (Aspartase)

261D

tetramer interface
184R, 185T, 186H, 187L, 191V, 197Q, 198E, 204G, 208R, 212R, 230V, 260E, 261D, 264D, 267R, 268N, 270D, 273V, 274Y, 277S, 280K, 281T, 284V, 285N, 287S, 288K, 291N, 292D, 342D, 350E, 353Q, 354L, 355E, 408T
CDD
cd01357 (Aspartase)

264D

tetramer interface
184R, 185T, 186H, 187L, 191V, 197Q, 198E, 204G, 208R, 212R, 230V, 260E, 261D, 264D, 267R, 268N, 270D, 273V, 274Y, 277S, 280K, 281T, 284V, 285N, 287S, 288K, 291N, 292D, 342D, 350E, 353Q, 354L, 355E, 408T
CDD
cd01357 (Aspartase)

267R

tetramer interface
184R, 185T, 186H, 187L, 191V, 197Q, 198E, 204G, 208R, 212R, 230V, 260E, 261D, 264D, 267R, 268N, 270D, 273V, 274Y, 277S, 280K, 281T, 284V, 285N, 287S, 288K, 291N, 292D, 342D, 350E, 353Q, 354L, 355E, 408T
CDD
cd01357 (Aspartase)

268N

tetramer interface
184R, 185T, 186H, 187L, 191V, 197Q, 198E, 204G, 208R, 212R, 230V, 260E, 261D, 264D, 267R, 268N, 270D, 273V, 274Y, 277S, 280K, 281T, 284V, 285N, 287S, 288K, 291N, 292D, 342D, 350E, 353Q, 354L, 355E, 408T
CDD
cd01357 (Aspartase)

270D

tetramer interface
184R, 185T, 186H, 187L, 191V, 197Q, 198E, 204G, 208R, 212R, 230V, 260E, 261D, 264D, 267R, 268N, 270D, 273V, 274Y, 277S, 280K, 281T, 284V, 285N, 287S, 288K, 291N, 292D, 342D, 350E, 353Q, 354L, 355E, 408T
CDD
cd01357 (Aspartase)

273V

tetramer interface
184R, 185T, 186H, 187L, 191V, 197Q, 198E, 204G, 208R, 212R, 230V, 260E, 261D, 264D, 267R, 268N, 270D, 273V, 274Y, 277S, 280K, 281T, 284V, 285N, 287S, 288K, 291N, 292D, 342D, 350E, 353Q, 354L, 355E, 408T
CDD
cd01357 (Aspartase)

274Y

tetramer interface
184R, 185T, 186H, 187L, 191V, 197Q, 198E, 204G, 208R, 212R, 230V, 260E, 261D, 264D, 267R, 268N, 270D, 273V, 274Y, 277S, 280K, 281T, 284V, 285N, 287S, 288K, 291N, 292D, 342D, 350E, 353Q, 354L, 355E, 408T
CDD
cd01357 (Aspartase)

277S

tetramer interface
184R, 185T, 186H, 187L, 191V, 197Q, 198E, 204G, 208R, 212R, 230V, 260E, 261D, 264D, 267R, 268N, 270D, 273V, 274Y, 277S, 280K, 281T, 284V, 285N, 287S, 288K, 291N, 292D, 342D, 350E, 353Q, 354L, 355E, 408T
CDD
cd01357 (Aspartase)

280K

tetramer interface
184R, 185T, 186H, 187L, 191V, 197Q, 198E, 204G, 208R, 212R, 230V, 260E, 261D, 264D, 267R, 268N, 270D, 273V, 274Y, 277S, 280K, 281T, 284V, 285N, 287S, 288K, 291N, 292D, 342D, 350E, 353Q, 354L, 355E, 408T
CDD
cd01357 (Aspartase)

281T

tetramer interface
184R, 185T, 186H, 187L, 191V, 197Q, 198E, 204G, 208R, 212R, 230V, 260E, 261D, 264D, 267R, 268N, 270D, 273V, 274Y, 277S, 280K, 281T, 284V, 285N, 287S, 288K, 291N, 292D, 342D, 350E, 353Q, 354L, 355E, 408T
CDD
cd01357 (Aspartase)

284V

tetramer interface
184R, 185T, 186H, 187L, 191V, 197Q, 198E, 204G, 208R, 212R, 230V, 260E, 261D, 264D, 267R, 268N, 270D, 273V, 274Y, 277S, 280K, 281T, 284V, 285N, 287S, 288K, 291N, 292D, 342D, 350E, 353Q, 354L, 355E, 408T
CDD
cd01357 (Aspartase)

285N

tetramer interface
184R, 185T, 186H, 187L, 191V, 197Q, 198E, 204G, 208R, 212R, 230V, 260E, 261D, 264D, 267R, 268N, 270D, 273V, 274Y, 277S, 280K, 281T, 284V, 285N, 287S, 288K, 291N, 292D, 342D, 350E, 353Q, 354L, 355E, 408T
CDD
cd01357 (Aspartase)

287S

tetramer interface
184R, 185T, 186H, 187L, 191V, 197Q, 198E, 204G, 208R, 212R, 230V, 260E, 261D, 264D, 267R, 268N, 270D, 273V, 274Y, 277S, 280K, 281T, 284V, 285N, 287S, 288K, 291N, 292D, 342D, 350E, 353Q, 354L, 355E, 408T
CDD
cd01357 (Aspartase)

288K

tetramer interface
184R, 185T, 186H, 187L, 191V, 197Q, 198E, 204G, 208R, 212R, 230V, 260E, 261D, 264D, 267R, 268N, 270D, 273V, 274Y, 277S, 280K, 281T, 284V, 285N, 287S, 288K, 291N, 292D, 342D, 350E, 353Q, 354L, 355E, 408T
CDD
cd01357 (Aspartase)

291N

tetramer interface
184R, 185T, 186H, 187L, 191V, 197Q, 198E, 204G, 208R, 212R, 230V, 260E, 261D, 264D, 267R, 268N, 270D, 273V, 274Y, 277S, 280K, 281T, 284V, 285N, 287S, 288K, 291N, 292D, 342D, 350E, 353Q, 354L, 355E, 408T
CDD
cd01357 (Aspartase)

292D

tetramer interface
184R, 185T, 186H, 187L, 191V, 197Q, 198E, 204G, 208R, 212R, 230V, 260E, 261D, 264D, 267R, 268N, 270D, 273V, 274Y, 277S, 280K, 281T, 284V, 285N, 287S, 288K, 291N, 292D, 342D, 350E, 353Q, 354L, 355E, 408T
CDD
cd01357 (Aspartase)

342D

tetramer interface
184R, 185T, 186H, 187L, 191V, 197Q, 198E, 204G, 208R, 212R, 230V, 260E, 261D, 264D, 267R, 268N, 270D, 273V, 274Y, 277S, 280K, 281T, 284V, 285N, 287S, 288K, 291N, 292D, 342D, 350E, 353Q, 354L, 355E, 408T
CDD
cd01357 (Aspartase)

350E

tetramer interface
184R, 185T, 186H, 187L, 191V, 197Q, 198E, 204G, 208R, 212R, 230V, 260E, 261D, 264D, 267R, 268N, 270D, 273V, 274Y, 277S, 280K, 281T, 284V, 285N, 287S, 288K, 291N, 292D, 342D, 350E, 353Q, 354L, 355E, 408T
CDD
cd01357 (Aspartase)

353Q

tetramer interface
184R, 185T, 186H, 187L, 191V, 197Q, 198E, 204G, 208R, 212R, 230V, 260E, 261D, 264D, 267R, 268N, 270D, 273V, 274Y, 277S, 280K, 281T, 284V, 285N, 287S, 288K, 291N, 292D, 342D, 350E, 353Q, 354L, 355E, 408T
CDD
cd01357 (Aspartase)

354L

tetramer interface
184R, 185T, 186H, 187L, 191V, 197Q, 198E, 204G, 208R, 212R, 230V, 260E, 261D, 264D, 267R, 268N, 270D, 273V, 274Y, 277S, 280K, 281T, 284V, 285N, 287S, 288K, 291N, 292D, 342D, 350E, 353Q, 354L, 355E, 408T
CDD
cd01357 (Aspartase)

355E

tetramer interface
184R, 185T, 186H, 187L, 191V, 197Q, 198E, 204G, 208R, 212R, 230V, 260E, 261D, 264D, 267R, 268N, 270D, 273V, 274Y, 277S, 280K, 281T, 284V, 285N, 287S, 288K, 291N, 292D, 342D, 350E, 353Q, 354L, 355E, 408T
CDD
cd01357 (Aspartase)

408T

tetramer interface
184R, 185T, 186H, 187L, 191V, 197Q, 198E, 204G, 208R, 212R, 230V, 260E, 261D, 264D, 267R, 268N, 270D, 273V, 274Y, 277S, 280K, 281T, 284V, 285N, 287S, 288K, 291N, 292D, 342D, 350E, 353Q, 354L, 355E, 408T
CDD
cd01357 (Aspartase)

GO term prediction

Biological Process

GO:0006099 tricarboxylic acid cycle

Molecular Function

GO:0003824 catalytic activity
GO:0016829 lyase activity

Cellular Component

None predicted.

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Entry type

Status

Per-residue features

25563_FusoPortal_Gene_919

Protein family membership

Homologous superfamilies

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component