25586_FusoPortal_Gene_1274

Protein

25586_FusoPortal_Gene_1274

Length

412 amino acids

Protein family membership

Peptidase M20 (IPR002933)
- Peptidase M20B, tripeptide aminopeptidase (IPR010161)

Homologous superfamilies

Homologous superfamily
214 - 325
Bacterial exopeptidase dimerisation domain (IPR036264)

1 50 100 150 200 250 300 350 412

Domains and repeats

Domain
212 - 311
Peptidase M20, dimerisation domain (IPR011650)

1 50 100 150 200 250 300 350 412

Detailed signature matches

IPR036264

Bacterial exopeptidase dimerisation domain
1. SSF55031 (Bacterial...)
  
  214 - 325
  
  SUPERFAMILY
  SSF55031 (Bacterial exopeptidase dimerisation domain)
IPR002933

Peptidase M20
1. PF01546 (Peptidase_M20)
  
  144 - 407
  
  Pfam
  PF01546 (Peptidase_M20)
IPR010161

Peptidase M20B, tripeptide aminopeptidase
1. PIRSF037215 (Peptid...)
  
  4 - 412
  
  PIRSF
  PIRSF037215 (Peptidase_T)
2. PTHR42994:SF1 (PEPT...)
  
  5 - 411
  
  PANTHER
  PTHR42994:SF1 (PEPTIDASE T)
3. TIGR01882
  
  5 - 412
  
  TIGRFAMs
  TIGR01882 (TIGR01882)
4. cd03892 (M20_peptT)
  
  9 - 408
  
  CDD
  cd03892 (M20_peptT)
5. MF_00550 (Aminopept...)
  
  6 - 409
  
  HAMAP
  MF_00550 (Aminopeptidase_M20)
IPR011650

Peptidase M20, dimerisation domain
1. PF07687 (M20_dimer)
  
  212 - 311
  
  Pfam
  PF07687 (M20_dimer)
IPR001261

ArgE/DapE/ACY1/CPG2/YscS, conserved site
1. PS00759 (ARGE_DAPE_...)
  
  143 - 182
  
  PROSITE patterns
  PS00759 (ARGE_DAPE_CPG2_2)
2. PS00758 (ARGE_DAPE_...)
  
  78 - 87
  
  PROSITE patterns
  PS00758 (ARGE_DAPE_CPG2_1)

no IPR

Unintegrated signatures

G3DSA:3.40.63...

3 - 412

GENE3D
G3DSA:3.40.630.10 (G3DSA:3.40.630.10)
PTHR42994 (FAMILY N...)

5 - 411

PANTHER
PTHR42994 (FAMILY NOT NAMED)
SSF53187 (Zn-depend...)

8 - 215

SUPERFAMILY
SSF53187 (Zn-dependent exopeptidases)

327 - 409

SUPERFAMILY
SSF53187 (Zn-dependent exopeptidases)

Residue annotation

metal binding site...

83H

metal binding site
83H, 145D, 179E, 180E, 202D, 384H
CDD
cd03892 (M20_peptT)

145D

metal binding site
83H, 145D, 179E, 180E, 202D, 384H
CDD
cd03892 (M20_peptT)

179E

metal binding site
83H, 145D, 179E, 180E, 202D, 384H
CDD
cd03892 (M20_peptT)

180E

metal binding site
83H, 145D, 179E, 180E, 202D, 384H
CDD
cd03892 (M20_peptT)

202D

metal binding site
83H, 145D, 179E, 180E, 202D, 384H
CDD
cd03892 (M20_peptT)

384H

metal binding site
83H, 145D, 179E, 180E, 202D, 384H
CDD
cd03892 (M20_peptT)
dimer interface cd...

89F

dimer interface
89F, 229H, 230P, 231G, 233A, 234K, 235G, 237M, 239N, 241S, 242L, 245S, 248I, 257P, 258E, 259K, 260T, 261E, 266F, 268F, 269L, 270D, 271E, 272M, 273K, 274S, 275N, 276C, 358R, 384H
CDD
cd03892 (M20_peptT)

229H

dimer interface
89F, 229H, 230P, 231G, 233A, 234K, 235G, 237M, 239N, 241S, 242L, 245S, 248I, 257P, 258E, 259K, 260T, 261E, 266F, 268F, 269L, 270D, 271E, 272M, 273K, 274S, 275N, 276C, 358R, 384H
CDD
cd03892 (M20_peptT)

230P

dimer interface
89F, 229H, 230P, 231G, 233A, 234K, 235G, 237M, 239N, 241S, 242L, 245S, 248I, 257P, 258E, 259K, 260T, 261E, 266F, 268F, 269L, 270D, 271E, 272M, 273K, 274S, 275N, 276C, 358R, 384H
CDD
cd03892 (M20_peptT)

231G

dimer interface
89F, 229H, 230P, 231G, 233A, 234K, 235G, 237M, 239N, 241S, 242L, 245S, 248I, 257P, 258E, 259K, 260T, 261E, 266F, 268F, 269L, 270D, 271E, 272M, 273K, 274S, 275N, 276C, 358R, 384H
CDD
cd03892 (M20_peptT)

233A

dimer interface
89F, 229H, 230P, 231G, 233A, 234K, 235G, 237M, 239N, 241S, 242L, 245S, 248I, 257P, 258E, 259K, 260T, 261E, 266F, 268F, 269L, 270D, 271E, 272M, 273K, 274S, 275N, 276C, 358R, 384H
CDD
cd03892 (M20_peptT)

234K

dimer interface
89F, 229H, 230P, 231G, 233A, 234K, 235G, 237M, 239N, 241S, 242L, 245S, 248I, 257P, 258E, 259K, 260T, 261E, 266F, 268F, 269L, 270D, 271E, 272M, 273K, 274S, 275N, 276C, 358R, 384H
CDD
cd03892 (M20_peptT)

235G

dimer interface
89F, 229H, 230P, 231G, 233A, 234K, 235G, 237M, 239N, 241S, 242L, 245S, 248I, 257P, 258E, 259K, 260T, 261E, 266F, 268F, 269L, 270D, 271E, 272M, 273K, 274S, 275N, 276C, 358R, 384H
CDD
cd03892 (M20_peptT)

237M

dimer interface
89F, 229H, 230P, 231G, 233A, 234K, 235G, 237M, 239N, 241S, 242L, 245S, 248I, 257P, 258E, 259K, 260T, 261E, 266F, 268F, 269L, 270D, 271E, 272M, 273K, 274S, 275N, 276C, 358R, 384H
CDD
cd03892 (M20_peptT)

239N

dimer interface
89F, 229H, 230P, 231G, 233A, 234K, 235G, 237M, 239N, 241S, 242L, 245S, 248I, 257P, 258E, 259K, 260T, 261E, 266F, 268F, 269L, 270D, 271E, 272M, 273K, 274S, 275N, 276C, 358R, 384H
CDD
cd03892 (M20_peptT)

241S

dimer interface
89F, 229H, 230P, 231G, 233A, 234K, 235G, 237M, 239N, 241S, 242L, 245S, 248I, 257P, 258E, 259K, 260T, 261E, 266F, 268F, 269L, 270D, 271E, 272M, 273K, 274S, 275N, 276C, 358R, 384H
CDD
cd03892 (M20_peptT)

242L

dimer interface
89F, 229H, 230P, 231G, 233A, 234K, 235G, 237M, 239N, 241S, 242L, 245S, 248I, 257P, 258E, 259K, 260T, 261E, 266F, 268F, 269L, 270D, 271E, 272M, 273K, 274S, 275N, 276C, 358R, 384H
CDD
cd03892 (M20_peptT)

245S

dimer interface
89F, 229H, 230P, 231G, 233A, 234K, 235G, 237M, 239N, 241S, 242L, 245S, 248I, 257P, 258E, 259K, 260T, 261E, 266F, 268F, 269L, 270D, 271E, 272M, 273K, 274S, 275N, 276C, 358R, 384H
CDD
cd03892 (M20_peptT)

248I

dimer interface
89F, 229H, 230P, 231G, 233A, 234K, 235G, 237M, 239N, 241S, 242L, 245S, 248I, 257P, 258E, 259K, 260T, 261E, 266F, 268F, 269L, 270D, 271E, 272M, 273K, 274S, 275N, 276C, 358R, 384H
CDD
cd03892 (M20_peptT)

257P

dimer interface
89F, 229H, 230P, 231G, 233A, 234K, 235G, 237M, 239N, 241S, 242L, 245S, 248I, 257P, 258E, 259K, 260T, 261E, 266F, 268F, 269L, 270D, 271E, 272M, 273K, 274S, 275N, 276C, 358R, 384H
CDD
cd03892 (M20_peptT)

258E

dimer interface
89F, 229H, 230P, 231G, 233A, 234K, 235G, 237M, 239N, 241S, 242L, 245S, 248I, 257P, 258E, 259K, 260T, 261E, 266F, 268F, 269L, 270D, 271E, 272M, 273K, 274S, 275N, 276C, 358R, 384H
CDD
cd03892 (M20_peptT)

259K

dimer interface
89F, 229H, 230P, 231G, 233A, 234K, 235G, 237M, 239N, 241S, 242L, 245S, 248I, 257P, 258E, 259K, 260T, 261E, 266F, 268F, 269L, 270D, 271E, 272M, 273K, 274S, 275N, 276C, 358R, 384H
CDD
cd03892 (M20_peptT)

260T

dimer interface
89F, 229H, 230P, 231G, 233A, 234K, 235G, 237M, 239N, 241S, 242L, 245S, 248I, 257P, 258E, 259K, 260T, 261E, 266F, 268F, 269L, 270D, 271E, 272M, 273K, 274S, 275N, 276C, 358R, 384H
CDD
cd03892 (M20_peptT)

261E

dimer interface
89F, 229H, 230P, 231G, 233A, 234K, 235G, 237M, 239N, 241S, 242L, 245S, 248I, 257P, 258E, 259K, 260T, 261E, 266F, 268F, 269L, 270D, 271E, 272M, 273K, 274S, 275N, 276C, 358R, 384H
CDD
cd03892 (M20_peptT)

266F

dimer interface
89F, 229H, 230P, 231G, 233A, 234K, 235G, 237M, 239N, 241S, 242L, 245S, 248I, 257P, 258E, 259K, 260T, 261E, 266F, 268F, 269L, 270D, 271E, 272M, 273K, 274S, 275N, 276C, 358R, 384H
CDD
cd03892 (M20_peptT)

268F

dimer interface
89F, 229H, 230P, 231G, 233A, 234K, 235G, 237M, 239N, 241S, 242L, 245S, 248I, 257P, 258E, 259K, 260T, 261E, 266F, 268F, 269L, 270D, 271E, 272M, 273K, 274S, 275N, 276C, 358R, 384H
CDD
cd03892 (M20_peptT)

269L

dimer interface
89F, 229H, 230P, 231G, 233A, 234K, 235G, 237M, 239N, 241S, 242L, 245S, 248I, 257P, 258E, 259K, 260T, 261E, 266F, 268F, 269L, 270D, 271E, 272M, 273K, 274S, 275N, 276C, 358R, 384H
CDD
cd03892 (M20_peptT)

270D

dimer interface
89F, 229H, 230P, 231G, 233A, 234K, 235G, 237M, 239N, 241S, 242L, 245S, 248I, 257P, 258E, 259K, 260T, 261E, 266F, 268F, 269L, 270D, 271E, 272M, 273K, 274S, 275N, 276C, 358R, 384H
CDD
cd03892 (M20_peptT)

271E

dimer interface
89F, 229H, 230P, 231G, 233A, 234K, 235G, 237M, 239N, 241S, 242L, 245S, 248I, 257P, 258E, 259K, 260T, 261E, 266F, 268F, 269L, 270D, 271E, 272M, 273K, 274S, 275N, 276C, 358R, 384H
CDD
cd03892 (M20_peptT)

272M

dimer interface
89F, 229H, 230P, 231G, 233A, 234K, 235G, 237M, 239N, 241S, 242L, 245S, 248I, 257P, 258E, 259K, 260T, 261E, 266F, 268F, 269L, 270D, 271E, 272M, 273K, 274S, 275N, 276C, 358R, 384H
CDD
cd03892 (M20_peptT)

273K

dimer interface
89F, 229H, 230P, 231G, 233A, 234K, 235G, 237M, 239N, 241S, 242L, 245S, 248I, 257P, 258E, 259K, 260T, 261E, 266F, 268F, 269L, 270D, 271E, 272M, 273K, 274S, 275N, 276C, 358R, 384H
CDD
cd03892 (M20_peptT)

274S

dimer interface
89F, 229H, 230P, 231G, 233A, 234K, 235G, 237M, 239N, 241S, 242L, 245S, 248I, 257P, 258E, 259K, 260T, 261E, 266F, 268F, 269L, 270D, 271E, 272M, 273K, 274S, 275N, 276C, 358R, 384H
CDD
cd03892 (M20_peptT)

275N

dimer interface
89F, 229H, 230P, 231G, 233A, 234K, 235G, 237M, 239N, 241S, 242L, 245S, 248I, 257P, 258E, 259K, 260T, 261E, 266F, 268F, 269L, 270D, 271E, 272M, 273K, 274S, 275N, 276C, 358R, 384H
CDD
cd03892 (M20_peptT)

276C

dimer interface
89F, 229H, 230P, 231G, 233A, 234K, 235G, 237M, 239N, 241S, 242L, 245S, 248I, 257P, 258E, 259K, 260T, 261E, 266F, 268F, 269L, 270D, 271E, 272M, 273K, 274S, 275N, 276C, 358R, 384H
CDD
cd03892 (M20_peptT)

358R

dimer interface
89F, 229H, 230P, 231G, 233A, 234K, 235G, 237M, 239N, 241S, 242L, 245S, 248I, 257P, 258E, 259K, 260T, 261E, 266F, 268F, 269L, 270D, 271E, 272M, 273K, 274S, 275N, 276C, 358R, 384H
CDD
cd03892 (M20_peptT)

384H

dimer interface
89F, 229H, 230P, 231G, 233A, 234K, 235G, 237M, 239N, 241S, 242L, 245S, 248I, 257P, 258E, 259K, 260T, 261E, 266F, 268F, 269L, 270D, 271E, 272M, 273K, 274S, 275N, 276C, 358R, 384H
CDD
cd03892 (M20_peptT)

GO term prediction

Biological Process

GO:0006508 proteolysis
GO:0006518 peptide metabolic process
GO:0008152 metabolic process

Molecular Function

GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
GO:0045148 tripeptide aminopeptidase activity

Cellular Component

GO:0005737 cytoplasm

Filter view on

Entry type

Status

Per-residue features

25586_FusoPortal_Gene_1274

Protein family membership

Homologous superfamilies

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component