25586_FusoPortal_Gene_1291

Protein

25586_FusoPortal_Gene_1291

Length

336 amino acids

Protein family membership

Asparaginase/glutaminase-like (IPR006034)
- L-asparaginase, type I (IPR006033)

Homologous superfamilies

Homologous superfamily
1 - 208
L-asparaginase, N-terminal domain superfamily (IPR037152)
209 - 336
L-asparaginase, C-terminal (IPR027473)
Homologous superfamily
3 - 335
Asparaginase/glutaminase-like superfamily (IPR036152)

1 50 100 150 200 250 300 336

Domains and repeats

Domain
4 - 190
L-asparaginase, N-terminal (IPR027474)

1 50 100 150 200 250 300 336

Detailed signature matches

IPR037152

L-asparaginase, N-terminal domain superfamily
1. G3DSA:3.40.50...
  
  1 - 208
  
  GENE3D
  G3DSA:3.40.50.1170 (G3DSA:3.40.50.1170)
IPR036152

Asparaginase/glutaminase-like superfamily
1. SSF53774 (Glutamina...)
  
  3 - 335
  
  SUPERFAMILY
  SSF53774 (Glutaminase/Asparaginase)
IPR027473

L-asparaginase, C-terminal
1. G3DSA:3.40.50.40
  
  209 - 336
  
  GENE3D
  G3DSA:3.40.50.40 (G3DSA:3.40.50.40)
IPR006034

Asparaginase/glutaminase-like
1. PIRSF001220 (L-ASNa...)
  
  1 - 334
  
  PIRSF
  PIRSF001220 (L-ASNase_gatD)
2. PR00139 (ASNGLNASE)
  
  5 - 16
  
  PRINTS
  PR00139 (ASNGLNASE)
  
  260 - 278
  
  PRINTS
  PR00139 (ASNGLNASE)
  
  76 - 94
  
  PRINTS
  PR00139 (ASNGLNASE)
3. PS51732 (ASN_GLN_ASE_3)
  
  3 - 329
  
  PROSITE profiles
  PS51732 (ASN_GLN_ASE_3)
IPR006033

L-asparaginase, type I
1. TIGR00519
  
  4 - 333
  
  TIGRFAMs
  TIGR00519 (TIGR00519)
IPR027474

L-asparaginase, N-terminal
1. PF00710 (Asparaginase)
  
  4 - 190
  
  Pfam
  PF00710 (Asparaginase)
IPR020827

Asparaginase/glutaminase, active site 1
1. PS00144 (ASN_GLN_ASE_1)
  
  7 - 15
  
  PROSITE patterns
  PS00144 (ASN_GLN_ASE_1)
IPR027475

Asparaginase/glutaminase, active site 2
1. PS00917 (ASN_GLN_ASE_2)
  
  77 - 87
  
  PROSITE patterns
  PS00917 (ASN_GLN_ASE_2)

no IPR

Unintegrated signatures

PIRSF500176 (L_ASNase)

1 - 332

PIRSF
PIRSF500176 (L_ASNase)
PTHR11707 (L-ASPARA...)

2 - 336

PANTHER
PTHR11707 (L-ASPARAGINASE)
PTHR11707:SF28 (60 ...)

2 - 336

PANTHER
PTHR11707:SF28 (60 KDA LYSOPHOSPHOLIPASE)
SFLDS00057 (Glutami...)

2 - 335

SFLD
SFLDS00057 (Glutaminase/Asparaginase)
cd08963 (L-asparagi...)

3 - 323

CDD
cd08963 (L-asparaginase_I)

Residue annotation

active site cd08963

12G

active site
12G, 13T, 53S, 54S, 83G, 84T, 85D, 110A, 161K
CDD
cd08963 (L-asparaginase_I)

13T

active site
12G, 13T, 53S, 54S, 83G, 84T, 85D, 110A, 161K
CDD
cd08963 (L-asparaginase_I)

53S

active site
12G, 13T, 53S, 54S, 83G, 84T, 85D, 110A, 161K
CDD
cd08963 (L-asparaginase_I)

54S

active site
12G, 13T, 53S, 54S, 83G, 84T, 85D, 110A, 161K
CDD
cd08963 (L-asparaginase_I)

83G

active site
12G, 13T, 53S, 54S, 83G, 84T, 85D, 110A, 161K
CDD
cd08963 (L-asparaginase_I)

84T

active site
12G, 13T, 53S, 54S, 83G, 84T, 85D, 110A, 161K
CDD
cd08963 (L-asparaginase_I)

85D

active site
12G, 13T, 53S, 54S, 83G, 84T, 85D, 110A, 161K
CDD
cd08963 (L-asparaginase_I)

110A

active site
12G, 13T, 53S, 54S, 83G, 84T, 85D, 110A, 161K
CDD
cd08963 (L-asparaginase_I)

161K

active site
12G, 13T, 53S, 54S, 83G, 84T, 85D, 110A, 161K
CDD
cd08963 (L-asparaginase_I)
SFLDS00057

13T

SFLD_Res01
13T, 108T
SFLD
SFLDS00057 (Glutaminase/Asparaginase)

108T

SFLD_Res01
13T, 108T
SFLD
SFLDS00057 (Glutaminase/Asparaginase)
homodimer interfac...

13T

homodimer interface
13T, 20P, 21L, 22R, 49K, 52D, 53S, 54S, 55D, 56V, 57T, 58T, 60F, 61W, 85D, 86T, 89Y, 111Q, 112A, 161K, 162T, 163D, 164S, 165N, 166N, 209N, 210V, 211L, 212L, 213L, 214E, 215L, 216F, 217P, 218G, 219L, 221S, 222K, 226D, 230S, 231N, 240K, 242Y, 243G, 244S, 248P, 272Q, 275S, 276G, 277S, 278V, 279K, 283Y, 302S, 306L, 310M
CDD
cd08963 (L-asparaginase_I)

20P

homodimer interface
13T, 20P, 21L, 22R, 49K, 52D, 53S, 54S, 55D, 56V, 57T, 58T, 60F, 61W, 85D, 86T, 89Y, 111Q, 112A, 161K, 162T, 163D, 164S, 165N, 166N, 209N, 210V, 211L, 212L, 213L, 214E, 215L, 216F, 217P, 218G, 219L, 221S, 222K, 226D, 230S, 231N, 240K, 242Y, 243G, 244S, 248P, 272Q, 275S, 276G, 277S, 278V, 279K, 283Y, 302S, 306L, 310M
CDD
cd08963 (L-asparaginase_I)

21L

homodimer interface
13T, 20P, 21L, 22R, 49K, 52D, 53S, 54S, 55D, 56V, 57T, 58T, 60F, 61W, 85D, 86T, 89Y, 111Q, 112A, 161K, 162T, 163D, 164S, 165N, 166N, 209N, 210V, 211L, 212L, 213L, 214E, 215L, 216F, 217P, 218G, 219L, 221S, 222K, 226D, 230S, 231N, 240K, 242Y, 243G, 244S, 248P, 272Q, 275S, 276G, 277S, 278V, 279K, 283Y, 302S, 306L, 310M
CDD
cd08963 (L-asparaginase_I)

22R

homodimer interface
13T, 20P, 21L, 22R, 49K, 52D, 53S, 54S, 55D, 56V, 57T, 58T, 60F, 61W, 85D, 86T, 89Y, 111Q, 112A, 161K, 162T, 163D, 164S, 165N, 166N, 209N, 210V, 211L, 212L, 213L, 214E, 215L, 216F, 217P, 218G, 219L, 221S, 222K, 226D, 230S, 231N, 240K, 242Y, 243G, 244S, 248P, 272Q, 275S, 276G, 277S, 278V, 279K, 283Y, 302S, 306L, 310M
CDD
cd08963 (L-asparaginase_I)

49K

homodimer interface
13T, 20P, 21L, 22R, 49K, 52D, 53S, 54S, 55D, 56V, 57T, 58T, 60F, 61W, 85D, 86T, 89Y, 111Q, 112A, 161K, 162T, 163D, 164S, 165N, 166N, 209N, 210V, 211L, 212L, 213L, 214E, 215L, 216F, 217P, 218G, 219L, 221S, 222K, 226D, 230S, 231N, 240K, 242Y, 243G, 244S, 248P, 272Q, 275S, 276G, 277S, 278V, 279K, 283Y, 302S, 306L, 310M
CDD
cd08963 (L-asparaginase_I)

52D

homodimer interface
13T, 20P, 21L, 22R, 49K, 52D, 53S, 54S, 55D, 56V, 57T, 58T, 60F, 61W, 85D, 86T, 89Y, 111Q, 112A, 161K, 162T, 163D, 164S, 165N, 166N, 209N, 210V, 211L, 212L, 213L, 214E, 215L, 216F, 217P, 218G, 219L, 221S, 222K, 226D, 230S, 231N, 240K, 242Y, 243G, 244S, 248P, 272Q, 275S, 276G, 277S, 278V, 279K, 283Y, 302S, 306L, 310M
CDD
cd08963 (L-asparaginase_I)

53S

homodimer interface
13T, 20P, 21L, 22R, 49K, 52D, 53S, 54S, 55D, 56V, 57T, 58T, 60F, 61W, 85D, 86T, 89Y, 111Q, 112A, 161K, 162T, 163D, 164S, 165N, 166N, 209N, 210V, 211L, 212L, 213L, 214E, 215L, 216F, 217P, 218G, 219L, 221S, 222K, 226D, 230S, 231N, 240K, 242Y, 243G, 244S, 248P, 272Q, 275S, 276G, 277S, 278V, 279K, 283Y, 302S, 306L, 310M
CDD
cd08963 (L-asparaginase_I)

54S

homodimer interface
13T, 20P, 21L, 22R, 49K, 52D, 53S, 54S, 55D, 56V, 57T, 58T, 60F, 61W, 85D, 86T, 89Y, 111Q, 112A, 161K, 162T, 163D, 164S, 165N, 166N, 209N, 210V, 211L, 212L, 213L, 214E, 215L, 216F, 217P, 218G, 219L, 221S, 222K, 226D, 230S, 231N, 240K, 242Y, 243G, 244S, 248P, 272Q, 275S, 276G, 277S, 278V, 279K, 283Y, 302S, 306L, 310M
CDD
cd08963 (L-asparaginase_I)

55D

homodimer interface
13T, 20P, 21L, 22R, 49K, 52D, 53S, 54S, 55D, 56V, 57T, 58T, 60F, 61W, 85D, 86T, 89Y, 111Q, 112A, 161K, 162T, 163D, 164S, 165N, 166N, 209N, 210V, 211L, 212L, 213L, 214E, 215L, 216F, 217P, 218G, 219L, 221S, 222K, 226D, 230S, 231N, 240K, 242Y, 243G, 244S, 248P, 272Q, 275S, 276G, 277S, 278V, 279K, 283Y, 302S, 306L, 310M
CDD
cd08963 (L-asparaginase_I)

56V

homodimer interface
13T, 20P, 21L, 22R, 49K, 52D, 53S, 54S, 55D, 56V, 57T, 58T, 60F, 61W, 85D, 86T, 89Y, 111Q, 112A, 161K, 162T, 163D, 164S, 165N, 166N, 209N, 210V, 211L, 212L, 213L, 214E, 215L, 216F, 217P, 218G, 219L, 221S, 222K, 226D, 230S, 231N, 240K, 242Y, 243G, 244S, 248P, 272Q, 275S, 276G, 277S, 278V, 279K, 283Y, 302S, 306L, 310M
CDD
cd08963 (L-asparaginase_I)

57T

homodimer interface
13T, 20P, 21L, 22R, 49K, 52D, 53S, 54S, 55D, 56V, 57T, 58T, 60F, 61W, 85D, 86T, 89Y, 111Q, 112A, 161K, 162T, 163D, 164S, 165N, 166N, 209N, 210V, 211L, 212L, 213L, 214E, 215L, 216F, 217P, 218G, 219L, 221S, 222K, 226D, 230S, 231N, 240K, 242Y, 243G, 244S, 248P, 272Q, 275S, 276G, 277S, 278V, 279K, 283Y, 302S, 306L, 310M
CDD
cd08963 (L-asparaginase_I)

58T

homodimer interface
13T, 20P, 21L, 22R, 49K, 52D, 53S, 54S, 55D, 56V, 57T, 58T, 60F, 61W, 85D, 86T, 89Y, 111Q, 112A, 161K, 162T, 163D, 164S, 165N, 166N, 209N, 210V, 211L, 212L, 213L, 214E, 215L, 216F, 217P, 218G, 219L, 221S, 222K, 226D, 230S, 231N, 240K, 242Y, 243G, 244S, 248P, 272Q, 275S, 276G, 277S, 278V, 279K, 283Y, 302S, 306L, 310M
CDD
cd08963 (L-asparaginase_I)

60F

homodimer interface
13T, 20P, 21L, 22R, 49K, 52D, 53S, 54S, 55D, 56V, 57T, 58T, 60F, 61W, 85D, 86T, 89Y, 111Q, 112A, 161K, 162T, 163D, 164S, 165N, 166N, 209N, 210V, 211L, 212L, 213L, 214E, 215L, 216F, 217P, 218G, 219L, 221S, 222K, 226D, 230S, 231N, 240K, 242Y, 243G, 244S, 248P, 272Q, 275S, 276G, 277S, 278V, 279K, 283Y, 302S, 306L, 310M
CDD
cd08963 (L-asparaginase_I)

61W

homodimer interface
13T, 20P, 21L, 22R, 49K, 52D, 53S, 54S, 55D, 56V, 57T, 58T, 60F, 61W, 85D, 86T, 89Y, 111Q, 112A, 161K, 162T, 163D, 164S, 165N, 166N, 209N, 210V, 211L, 212L, 213L, 214E, 215L, 216F, 217P, 218G, 219L, 221S, 222K, 226D, 230S, 231N, 240K, 242Y, 243G, 244S, 248P, 272Q, 275S, 276G, 277S, 278V, 279K, 283Y, 302S, 306L, 310M
CDD
cd08963 (L-asparaginase_I)

85D

homodimer interface
13T, 20P, 21L, 22R, 49K, 52D, 53S, 54S, 55D, 56V, 57T, 58T, 60F, 61W, 85D, 86T, 89Y, 111Q, 112A, 161K, 162T, 163D, 164S, 165N, 166N, 209N, 210V, 211L, 212L, 213L, 214E, 215L, 216F, 217P, 218G, 219L, 221S, 222K, 226D, 230S, 231N, 240K, 242Y, 243G, 244S, 248P, 272Q, 275S, 276G, 277S, 278V, 279K, 283Y, 302S, 306L, 310M
CDD
cd08963 (L-asparaginase_I)

86T

homodimer interface
13T, 20P, 21L, 22R, 49K, 52D, 53S, 54S, 55D, 56V, 57T, 58T, 60F, 61W, 85D, 86T, 89Y, 111Q, 112A, 161K, 162T, 163D, 164S, 165N, 166N, 209N, 210V, 211L, 212L, 213L, 214E, 215L, 216F, 217P, 218G, 219L, 221S, 222K, 226D, 230S, 231N, 240K, 242Y, 243G, 244S, 248P, 272Q, 275S, 276G, 277S, 278V, 279K, 283Y, 302S, 306L, 310M
CDD
cd08963 (L-asparaginase_I)

89Y

homodimer interface
13T, 20P, 21L, 22R, 49K, 52D, 53S, 54S, 55D, 56V, 57T, 58T, 60F, 61W, 85D, 86T, 89Y, 111Q, 112A, 161K, 162T, 163D, 164S, 165N, 166N, 209N, 210V, 211L, 212L, 213L, 214E, 215L, 216F, 217P, 218G, 219L, 221S, 222K, 226D, 230S, 231N, 240K, 242Y, 243G, 244S, 248P, 272Q, 275S, 276G, 277S, 278V, 279K, 283Y, 302S, 306L, 310M
CDD
cd08963 (L-asparaginase_I)

111Q

homodimer interface
13T, 20P, 21L, 22R, 49K, 52D, 53S, 54S, 55D, 56V, 57T, 58T, 60F, 61W, 85D, 86T, 89Y, 111Q, 112A, 161K, 162T, 163D, 164S, 165N, 166N, 209N, 210V, 211L, 212L, 213L, 214E, 215L, 216F, 217P, 218G, 219L, 221S, 222K, 226D, 230S, 231N, 240K, 242Y, 243G, 244S, 248P, 272Q, 275S, 276G, 277S, 278V, 279K, 283Y, 302S, 306L, 310M
CDD
cd08963 (L-asparaginase_I)

112A

homodimer interface
13T, 20P, 21L, 22R, 49K, 52D, 53S, 54S, 55D, 56V, 57T, 58T, 60F, 61W, 85D, 86T, 89Y, 111Q, 112A, 161K, 162T, 163D, 164S, 165N, 166N, 209N, 210V, 211L, 212L, 213L, 214E, 215L, 216F, 217P, 218G, 219L, 221S, 222K, 226D, 230S, 231N, 240K, 242Y, 243G, 244S, 248P, 272Q, 275S, 276G, 277S, 278V, 279K, 283Y, 302S, 306L, 310M
CDD
cd08963 (L-asparaginase_I)

161K

homodimer interface
13T, 20P, 21L, 22R, 49K, 52D, 53S, 54S, 55D, 56V, 57T, 58T, 60F, 61W, 85D, 86T, 89Y, 111Q, 112A, 161K, 162T, 163D, 164S, 165N, 166N, 209N, 210V, 211L, 212L, 213L, 214E, 215L, 216F, 217P, 218G, 219L, 221S, 222K, 226D, 230S, 231N, 240K, 242Y, 243G, 244S, 248P, 272Q, 275S, 276G, 277S, 278V, 279K, 283Y, 302S, 306L, 310M
CDD
cd08963 (L-asparaginase_I)

162T

homodimer interface
13T, 20P, 21L, 22R, 49K, 52D, 53S, 54S, 55D, 56V, 57T, 58T, 60F, 61W, 85D, 86T, 89Y, 111Q, 112A, 161K, 162T, 163D, 164S, 165N, 166N, 209N, 210V, 211L, 212L, 213L, 214E, 215L, 216F, 217P, 218G, 219L, 221S, 222K, 226D, 230S, 231N, 240K, 242Y, 243G, 244S, 248P, 272Q, 275S, 276G, 277S, 278V, 279K, 283Y, 302S, 306L, 310M
CDD
cd08963 (L-asparaginase_I)

163D

homodimer interface
13T, 20P, 21L, 22R, 49K, 52D, 53S, 54S, 55D, 56V, 57T, 58T, 60F, 61W, 85D, 86T, 89Y, 111Q, 112A, 161K, 162T, 163D, 164S, 165N, 166N, 209N, 210V, 211L, 212L, 213L, 214E, 215L, 216F, 217P, 218G, 219L, 221S, 222K, 226D, 230S, 231N, 240K, 242Y, 243G, 244S, 248P, 272Q, 275S, 276G, 277S, 278V, 279K, 283Y, 302S, 306L, 310M
CDD
cd08963 (L-asparaginase_I)

164S

homodimer interface
13T, 20P, 21L, 22R, 49K, 52D, 53S, 54S, 55D, 56V, 57T, 58T, 60F, 61W, 85D, 86T, 89Y, 111Q, 112A, 161K, 162T, 163D, 164S, 165N, 166N, 209N, 210V, 211L, 212L, 213L, 214E, 215L, 216F, 217P, 218G, 219L, 221S, 222K, 226D, 230S, 231N, 240K, 242Y, 243G, 244S, 248P, 272Q, 275S, 276G, 277S, 278V, 279K, 283Y, 302S, 306L, 310M
CDD
cd08963 (L-asparaginase_I)

165N

homodimer interface
13T, 20P, 21L, 22R, 49K, 52D, 53S, 54S, 55D, 56V, 57T, 58T, 60F, 61W, 85D, 86T, 89Y, 111Q, 112A, 161K, 162T, 163D, 164S, 165N, 166N, 209N, 210V, 211L, 212L, 213L, 214E, 215L, 216F, 217P, 218G, 219L, 221S, 222K, 226D, 230S, 231N, 240K, 242Y, 243G, 244S, 248P, 272Q, 275S, 276G, 277S, 278V, 279K, 283Y, 302S, 306L, 310M
CDD
cd08963 (L-asparaginase_I)

166N

homodimer interface
13T, 20P, 21L, 22R, 49K, 52D, 53S, 54S, 55D, 56V, 57T, 58T, 60F, 61W, 85D, 86T, 89Y, 111Q, 112A, 161K, 162T, 163D, 164S, 165N, 166N, 209N, 210V, 211L, 212L, 213L, 214E, 215L, 216F, 217P, 218G, 219L, 221S, 222K, 226D, 230S, 231N, 240K, 242Y, 243G, 244S, 248P, 272Q, 275S, 276G, 277S, 278V, 279K, 283Y, 302S, 306L, 310M
CDD
cd08963 (L-asparaginase_I)

209N

homodimer interface
13T, 20P, 21L, 22R, 49K, 52D, 53S, 54S, 55D, 56V, 57T, 58T, 60F, 61W, 85D, 86T, 89Y, 111Q, 112A, 161K, 162T, 163D, 164S, 165N, 166N, 209N, 210V, 211L, 212L, 213L, 214E, 215L, 216F, 217P, 218G, 219L, 221S, 222K, 226D, 230S, 231N, 240K, 242Y, 243G, 244S, 248P, 272Q, 275S, 276G, 277S, 278V, 279K, 283Y, 302S, 306L, 310M
CDD
cd08963 (L-asparaginase_I)

210V

homodimer interface
13T, 20P, 21L, 22R, 49K, 52D, 53S, 54S, 55D, 56V, 57T, 58T, 60F, 61W, 85D, 86T, 89Y, 111Q, 112A, 161K, 162T, 163D, 164S, 165N, 166N, 209N, 210V, 211L, 212L, 213L, 214E, 215L, 216F, 217P, 218G, 219L, 221S, 222K, 226D, 230S, 231N, 240K, 242Y, 243G, 244S, 248P, 272Q, 275S, 276G, 277S, 278V, 279K, 283Y, 302S, 306L, 310M
CDD
cd08963 (L-asparaginase_I)

211L

homodimer interface
13T, 20P, 21L, 22R, 49K, 52D, 53S, 54S, 55D, 56V, 57T, 58T, 60F, 61W, 85D, 86T, 89Y, 111Q, 112A, 161K, 162T, 163D, 164S, 165N, 166N, 209N, 210V, 211L, 212L, 213L, 214E, 215L, 216F, 217P, 218G, 219L, 221S, 222K, 226D, 230S, 231N, 240K, 242Y, 243G, 244S, 248P, 272Q, 275S, 276G, 277S, 278V, 279K, 283Y, 302S, 306L, 310M
CDD
cd08963 (L-asparaginase_I)

212L

homodimer interface
13T, 20P, 21L, 22R, 49K, 52D, 53S, 54S, 55D, 56V, 57T, 58T, 60F, 61W, 85D, 86T, 89Y, 111Q, 112A, 161K, 162T, 163D, 164S, 165N, 166N, 209N, 210V, 211L, 212L, 213L, 214E, 215L, 216F, 217P, 218G, 219L, 221S, 222K, 226D, 230S, 231N, 240K, 242Y, 243G, 244S, 248P, 272Q, 275S, 276G, 277S, 278V, 279K, 283Y, 302S, 306L, 310M
CDD
cd08963 (L-asparaginase_I)

213L

homodimer interface
13T, 20P, 21L, 22R, 49K, 52D, 53S, 54S, 55D, 56V, 57T, 58T, 60F, 61W, 85D, 86T, 89Y, 111Q, 112A, 161K, 162T, 163D, 164S, 165N, 166N, 209N, 210V, 211L, 212L, 213L, 214E, 215L, 216F, 217P, 218G, 219L, 221S, 222K, 226D, 230S, 231N, 240K, 242Y, 243G, 244S, 248P, 272Q, 275S, 276G, 277S, 278V, 279K, 283Y, 302S, 306L, 310M
CDD
cd08963 (L-asparaginase_I)

214E

homodimer interface
13T, 20P, 21L, 22R, 49K, 52D, 53S, 54S, 55D, 56V, 57T, 58T, 60F, 61W, 85D, 86T, 89Y, 111Q, 112A, 161K, 162T, 163D, 164S, 165N, 166N, 209N, 210V, 211L, 212L, 213L, 214E, 215L, 216F, 217P, 218G, 219L, 221S, 222K, 226D, 230S, 231N, 240K, 242Y, 243G, 244S, 248P, 272Q, 275S, 276G, 277S, 278V, 279K, 283Y, 302S, 306L, 310M
CDD
cd08963 (L-asparaginase_I)

215L

homodimer interface
13T, 20P, 21L, 22R, 49K, 52D, 53S, 54S, 55D, 56V, 57T, 58T, 60F, 61W, 85D, 86T, 89Y, 111Q, 112A, 161K, 162T, 163D, 164S, 165N, 166N, 209N, 210V, 211L, 212L, 213L, 214E, 215L, 216F, 217P, 218G, 219L, 221S, 222K, 226D, 230S, 231N, 240K, 242Y, 243G, 244S, 248P, 272Q, 275S, 276G, 277S, 278V, 279K, 283Y, 302S, 306L, 310M
CDD
cd08963 (L-asparaginase_I)

216F

homodimer interface
13T, 20P, 21L, 22R, 49K, 52D, 53S, 54S, 55D, 56V, 57T, 58T, 60F, 61W, 85D, 86T, 89Y, 111Q, 112A, 161K, 162T, 163D, 164S, 165N, 166N, 209N, 210V, 211L, 212L, 213L, 214E, 215L, 216F, 217P, 218G, 219L, 221S, 222K, 226D, 230S, 231N, 240K, 242Y, 243G, 244S, 248P, 272Q, 275S, 276G, 277S, 278V, 279K, 283Y, 302S, 306L, 310M
CDD
cd08963 (L-asparaginase_I)

217P

homodimer interface
13T, 20P, 21L, 22R, 49K, 52D, 53S, 54S, 55D, 56V, 57T, 58T, 60F, 61W, 85D, 86T, 89Y, 111Q, 112A, 161K, 162T, 163D, 164S, 165N, 166N, 209N, 210V, 211L, 212L, 213L, 214E, 215L, 216F, 217P, 218G, 219L, 221S, 222K, 226D, 230S, 231N, 240K, 242Y, 243G, 244S, 248P, 272Q, 275S, 276G, 277S, 278V, 279K, 283Y, 302S, 306L, 310M
CDD
cd08963 (L-asparaginase_I)

218G

homodimer interface
13T, 20P, 21L, 22R, 49K, 52D, 53S, 54S, 55D, 56V, 57T, 58T, 60F, 61W, 85D, 86T, 89Y, 111Q, 112A, 161K, 162T, 163D, 164S, 165N, 166N, 209N, 210V, 211L, 212L, 213L, 214E, 215L, 216F, 217P, 218G, 219L, 221S, 222K, 226D, 230S, 231N, 240K, 242Y, 243G, 244S, 248P, 272Q, 275S, 276G, 277S, 278V, 279K, 283Y, 302S, 306L, 310M
CDD
cd08963 (L-asparaginase_I)

219L

homodimer interface
13T, 20P, 21L, 22R, 49K, 52D, 53S, 54S, 55D, 56V, 57T, 58T, 60F, 61W, 85D, 86T, 89Y, 111Q, 112A, 161K, 162T, 163D, 164S, 165N, 166N, 209N, 210V, 211L, 212L, 213L, 214E, 215L, 216F, 217P, 218G, 219L, 221S, 222K, 226D, 230S, 231N, 240K, 242Y, 243G, 244S, 248P, 272Q, 275S, 276G, 277S, 278V, 279K, 283Y, 302S, 306L, 310M
CDD
cd08963 (L-asparaginase_I)

221S

homodimer interface
13T, 20P, 21L, 22R, 49K, 52D, 53S, 54S, 55D, 56V, 57T, 58T, 60F, 61W, 85D, 86T, 89Y, 111Q, 112A, 161K, 162T, 163D, 164S, 165N, 166N, 209N, 210V, 211L, 212L, 213L, 214E, 215L, 216F, 217P, 218G, 219L, 221S, 222K, 226D, 230S, 231N, 240K, 242Y, 243G, 244S, 248P, 272Q, 275S, 276G, 277S, 278V, 279K, 283Y, 302S, 306L, 310M
CDD
cd08963 (L-asparaginase_I)

222K

homodimer interface
13T, 20P, 21L, 22R, 49K, 52D, 53S, 54S, 55D, 56V, 57T, 58T, 60F, 61W, 85D, 86T, 89Y, 111Q, 112A, 161K, 162T, 163D, 164S, 165N, 166N, 209N, 210V, 211L, 212L, 213L, 214E, 215L, 216F, 217P, 218G, 219L, 221S, 222K, 226D, 230S, 231N, 240K, 242Y, 243G, 244S, 248P, 272Q, 275S, 276G, 277S, 278V, 279K, 283Y, 302S, 306L, 310M
CDD
cd08963 (L-asparaginase_I)

226D

homodimer interface
13T, 20P, 21L, 22R, 49K, 52D, 53S, 54S, 55D, 56V, 57T, 58T, 60F, 61W, 85D, 86T, 89Y, 111Q, 112A, 161K, 162T, 163D, 164S, 165N, 166N, 209N, 210V, 211L, 212L, 213L, 214E, 215L, 216F, 217P, 218G, 219L, 221S, 222K, 226D, 230S, 231N, 240K, 242Y, 243G, 244S, 248P, 272Q, 275S, 276G, 277S, 278V, 279K, 283Y, 302S, 306L, 310M
CDD
cd08963 (L-asparaginase_I)

230S

homodimer interface
13T, 20P, 21L, 22R, 49K, 52D, 53S, 54S, 55D, 56V, 57T, 58T, 60F, 61W, 85D, 86T, 89Y, 111Q, 112A, 161K, 162T, 163D, 164S, 165N, 166N, 209N, 210V, 211L, 212L, 213L, 214E, 215L, 216F, 217P, 218G, 219L, 221S, 222K, 226D, 230S, 231N, 240K, 242Y, 243G, 244S, 248P, 272Q, 275S, 276G, 277S, 278V, 279K, 283Y, 302S, 306L, 310M
CDD
cd08963 (L-asparaginase_I)

231N

homodimer interface
13T, 20P, 21L, 22R, 49K, 52D, 53S, 54S, 55D, 56V, 57T, 58T, 60F, 61W, 85D, 86T, 89Y, 111Q, 112A, 161K, 162T, 163D, 164S, 165N, 166N, 209N, 210V, 211L, 212L, 213L, 214E, 215L, 216F, 217P, 218G, 219L, 221S, 222K, 226D, 230S, 231N, 240K, 242Y, 243G, 244S, 248P, 272Q, 275S, 276G, 277S, 278V, 279K, 283Y, 302S, 306L, 310M
CDD
cd08963 (L-asparaginase_I)

240K

homodimer interface
13T, 20P, 21L, 22R, 49K, 52D, 53S, 54S, 55D, 56V, 57T, 58T, 60F, 61W, 85D, 86T, 89Y, 111Q, 112A, 161K, 162T, 163D, 164S, 165N, 166N, 209N, 210V, 211L, 212L, 213L, 214E, 215L, 216F, 217P, 218G, 219L, 221S, 222K, 226D, 230S, 231N, 240K, 242Y, 243G, 244S, 248P, 272Q, 275S, 276G, 277S, 278V, 279K, 283Y, 302S, 306L, 310M
CDD
cd08963 (L-asparaginase_I)

242Y

homodimer interface
13T, 20P, 21L, 22R, 49K, 52D, 53S, 54S, 55D, 56V, 57T, 58T, 60F, 61W, 85D, 86T, 89Y, 111Q, 112A, 161K, 162T, 163D, 164S, 165N, 166N, 209N, 210V, 211L, 212L, 213L, 214E, 215L, 216F, 217P, 218G, 219L, 221S, 222K, 226D, 230S, 231N, 240K, 242Y, 243G, 244S, 248P, 272Q, 275S, 276G, 277S, 278V, 279K, 283Y, 302S, 306L, 310M
CDD
cd08963 (L-asparaginase_I)

243G

homodimer interface
13T, 20P, 21L, 22R, 49K, 52D, 53S, 54S, 55D, 56V, 57T, 58T, 60F, 61W, 85D, 86T, 89Y, 111Q, 112A, 161K, 162T, 163D, 164S, 165N, 166N, 209N, 210V, 211L, 212L, 213L, 214E, 215L, 216F, 217P, 218G, 219L, 221S, 222K, 226D, 230S, 231N, 240K, 242Y, 243G, 244S, 248P, 272Q, 275S, 276G, 277S, 278V, 279K, 283Y, 302S, 306L, 310M
CDD
cd08963 (L-asparaginase_I)

244S

homodimer interface
13T, 20P, 21L, 22R, 49K, 52D, 53S, 54S, 55D, 56V, 57T, 58T, 60F, 61W, 85D, 86T, 89Y, 111Q, 112A, 161K, 162T, 163D, 164S, 165N, 166N, 209N, 210V, 211L, 212L, 213L, 214E, 215L, 216F, 217P, 218G, 219L, 221S, 222K, 226D, 230S, 231N, 240K, 242Y, 243G, 244S, 248P, 272Q, 275S, 276G, 277S, 278V, 279K, 283Y, 302S, 306L, 310M
CDD
cd08963 (L-asparaginase_I)

248P

homodimer interface
13T, 20P, 21L, 22R, 49K, 52D, 53S, 54S, 55D, 56V, 57T, 58T, 60F, 61W, 85D, 86T, 89Y, 111Q, 112A, 161K, 162T, 163D, 164S, 165N, 166N, 209N, 210V, 211L, 212L, 213L, 214E, 215L, 216F, 217P, 218G, 219L, 221S, 222K, 226D, 230S, 231N, 240K, 242Y, 243G, 244S, 248P, 272Q, 275S, 276G, 277S, 278V, 279K, 283Y, 302S, 306L, 310M
CDD
cd08963 (L-asparaginase_I)

272Q

homodimer interface
13T, 20P, 21L, 22R, 49K, 52D, 53S, 54S, 55D, 56V, 57T, 58T, 60F, 61W, 85D, 86T, 89Y, 111Q, 112A, 161K, 162T, 163D, 164S, 165N, 166N, 209N, 210V, 211L, 212L, 213L, 214E, 215L, 216F, 217P, 218G, 219L, 221S, 222K, 226D, 230S, 231N, 240K, 242Y, 243G, 244S, 248P, 272Q, 275S, 276G, 277S, 278V, 279K, 283Y, 302S, 306L, 310M
CDD
cd08963 (L-asparaginase_I)

275S

homodimer interface
13T, 20P, 21L, 22R, 49K, 52D, 53S, 54S, 55D, 56V, 57T, 58T, 60F, 61W, 85D, 86T, 89Y, 111Q, 112A, 161K, 162T, 163D, 164S, 165N, 166N, 209N, 210V, 211L, 212L, 213L, 214E, 215L, 216F, 217P, 218G, 219L, 221S, 222K, 226D, 230S, 231N, 240K, 242Y, 243G, 244S, 248P, 272Q, 275S, 276G, 277S, 278V, 279K, 283Y, 302S, 306L, 310M
CDD
cd08963 (L-asparaginase_I)

276G

homodimer interface
13T, 20P, 21L, 22R, 49K, 52D, 53S, 54S, 55D, 56V, 57T, 58T, 60F, 61W, 85D, 86T, 89Y, 111Q, 112A, 161K, 162T, 163D, 164S, 165N, 166N, 209N, 210V, 211L, 212L, 213L, 214E, 215L, 216F, 217P, 218G, 219L, 221S, 222K, 226D, 230S, 231N, 240K, 242Y, 243G, 244S, 248P, 272Q, 275S, 276G, 277S, 278V, 279K, 283Y, 302S, 306L, 310M
CDD
cd08963 (L-asparaginase_I)

277S

homodimer interface
13T, 20P, 21L, 22R, 49K, 52D, 53S, 54S, 55D, 56V, 57T, 58T, 60F, 61W, 85D, 86T, 89Y, 111Q, 112A, 161K, 162T, 163D, 164S, 165N, 166N, 209N, 210V, 211L, 212L, 213L, 214E, 215L, 216F, 217P, 218G, 219L, 221S, 222K, 226D, 230S, 231N, 240K, 242Y, 243G, 244S, 248P, 272Q, 275S, 276G, 277S, 278V, 279K, 283Y, 302S, 306L, 310M
CDD
cd08963 (L-asparaginase_I)

278V

homodimer interface
13T, 20P, 21L, 22R, 49K, 52D, 53S, 54S, 55D, 56V, 57T, 58T, 60F, 61W, 85D, 86T, 89Y, 111Q, 112A, 161K, 162T, 163D, 164S, 165N, 166N, 209N, 210V, 211L, 212L, 213L, 214E, 215L, 216F, 217P, 218G, 219L, 221S, 222K, 226D, 230S, 231N, 240K, 242Y, 243G, 244S, 248P, 272Q, 275S, 276G, 277S, 278V, 279K, 283Y, 302S, 306L, 310M
CDD
cd08963 (L-asparaginase_I)

279K

homodimer interface
13T, 20P, 21L, 22R, 49K, 52D, 53S, 54S, 55D, 56V, 57T, 58T, 60F, 61W, 85D, 86T, 89Y, 111Q, 112A, 161K, 162T, 163D, 164S, 165N, 166N, 209N, 210V, 211L, 212L, 213L, 214E, 215L, 216F, 217P, 218G, 219L, 221S, 222K, 226D, 230S, 231N, 240K, 242Y, 243G, 244S, 248P, 272Q, 275S, 276G, 277S, 278V, 279K, 283Y, 302S, 306L, 310M
CDD
cd08963 (L-asparaginase_I)

283Y

homodimer interface
13T, 20P, 21L, 22R, 49K, 52D, 53S, 54S, 55D, 56V, 57T, 58T, 60F, 61W, 85D, 86T, 89Y, 111Q, 112A, 161K, 162T, 163D, 164S, 165N, 166N, 209N, 210V, 211L, 212L, 213L, 214E, 215L, 216F, 217P, 218G, 219L, 221S, 222K, 226D, 230S, 231N, 240K, 242Y, 243G, 244S, 248P, 272Q, 275S, 276G, 277S, 278V, 279K, 283Y, 302S, 306L, 310M
CDD
cd08963 (L-asparaginase_I)

302S

homodimer interface
13T, 20P, 21L, 22R, 49K, 52D, 53S, 54S, 55D, 56V, 57T, 58T, 60F, 61W, 85D, 86T, 89Y, 111Q, 112A, 161K, 162T, 163D, 164S, 165N, 166N, 209N, 210V, 211L, 212L, 213L, 214E, 215L, 216F, 217P, 218G, 219L, 221S, 222K, 226D, 230S, 231N, 240K, 242Y, 243G, 244S, 248P, 272Q, 275S, 276G, 277S, 278V, 279K, 283Y, 302S, 306L, 310M
CDD
cd08963 (L-asparaginase_I)

306L

homodimer interface
13T, 20P, 21L, 22R, 49K, 52D, 53S, 54S, 55D, 56V, 57T, 58T, 60F, 61W, 85D, 86T, 89Y, 111Q, 112A, 161K, 162T, 163D, 164S, 165N, 166N, 209N, 210V, 211L, 212L, 213L, 214E, 215L, 216F, 217P, 218G, 219L, 221S, 222K, 226D, 230S, 231N, 240K, 242Y, 243G, 244S, 248P, 272Q, 275S, 276G, 277S, 278V, 279K, 283Y, 302S, 306L, 310M
CDD
cd08963 (L-asparaginase_I)

310M

homodimer interface
13T, 20P, 21L, 22R, 49K, 52D, 53S, 54S, 55D, 56V, 57T, 58T, 60F, 61W, 85D, 86T, 89Y, 111Q, 112A, 161K, 162T, 163D, 164S, 165N, 166N, 209N, 210V, 211L, 212L, 213L, 214E, 215L, 216F, 217P, 218G, 219L, 221S, 222K, 226D, 230S, 231N, 240K, 242Y, 243G, 244S, 248P, 272Q, 275S, 276G, 277S, 278V, 279K, 283Y, 302S, 306L, 310M
CDD
cd08963 (L-asparaginase_I)

GO term prediction

Biological Process

GO:0006520 cellular amino acid metabolic process

Molecular Function

GO:0004067 asparaginase activity

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features

25586_FusoPortal_Gene_1291

Protein family membership

Homologous superfamilies

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component