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Protein

25586_FusoPortal_Gene_1527

Length

237 amino acids

Protein family membership

Phosphoribosylaminoimidazole-succinocarboxamide synthase (IPR001636)
- Bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide synthase (IPR033934)

Homologous superfamilies

None predicted.

Domains and repeats

Domain
4 - 235
SAICAR synthetase/ADE2, N-terminal (IPR028923)

1 50 100 150 200 237

Detailed signature matches

IPR001636

Phosphoribosylaminoimidazole-succinocarboxamide synthase

TIGR00081

7 - 234

TIGRFAMs
TIGR00081 (TIGR00081)

IPR033934

Bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide synthase

cd01415 (SAICAR_syn...)

7 - 235

CDD
cd01415 (SAICAR_synt_PurC)

IPR028923

SAICAR synthetase/ADE2, N-terminal

MF_00137 (SAICAR_synth)

4 - 235

HAMAP
MF_00137 (SAICAR_synth)
PF01259 (SAICAR_synt)

7 - 232

Pfam
PF01259 (SAICAR_synt)

IPR018236

SAICAR synthetase, conserved site

PS01057 (SAICAR_SYN...)

86 - 100

PROSITE patterns
PS01057 (SAICAR_SYNTHETASE_1)
PS01058 (SAICAR_SYN...)

173 - 181

PROSITE patterns
PS01058 (SAICAR_SYNTHETASE_2)

no IPR

Unintegrated signatures

G3DSA:3.30.20...

1 - 93

GENE3D
G3DSA:3.30.200.20 (G3DSA:3.30.200.20)
G3DSA:3.30.47...

94 - 221

GENE3D
G3DSA:3.30.470.20 (G3DSA:3.30.470.20)
PTHR43599 (FAMILY N...)

2 - 234

PANTHER
PTHR43599 (FAMILY NOT NAMED)
PTHR43599:SF2 (MULT...)

2 - 234

PANTHER
PTHR43599:SF2 (MULTIFUNCTIONAL PROTEIN ADE2)
SSF56104 (SAICAR sy...)

2 - 236

SUPERFAMILY
SSF56104 (SAICAR synthase-like)

Residue annotation

ATP binding site c...

7I

ATP binding site
7I, 8Y, 10G, 11K, 13K, 15L, 16Y, 24V, 26V, 69H, 82Q, 84V, 86I, 123K, 179E, 191A, 192D
CDD
cd01415 (SAICAR_synt_PurC)

8Y

ATP binding site
7I, 8Y, 10G, 11K, 13K, 15L, 16Y, 24V, 26V, 69H, 82Q, 84V, 86I, 123K, 179E, 191A, 192D
CDD
cd01415 (SAICAR_synt_PurC)

10G

ATP binding site
7I, 8Y, 10G, 11K, 13K, 15L, 16Y, 24V, 26V, 69H, 82Q, 84V, 86I, 123K, 179E, 191A, 192D
CDD
cd01415 (SAICAR_synt_PurC)

11K

ATP binding site
7I, 8Y, 10G, 11K, 13K, 15L, 16Y, 24V, 26V, 69H, 82Q, 84V, 86I, 123K, 179E, 191A, 192D
CDD
cd01415 (SAICAR_synt_PurC)

13K

ATP binding site
7I, 8Y, 10G, 11K, 13K, 15L, 16Y, 24V, 26V, 69H, 82Q, 84V, 86I, 123K, 179E, 191A, 192D
CDD
cd01415 (SAICAR_synt_PurC)

15L

ATP binding site
7I, 8Y, 10G, 11K, 13K, 15L, 16Y, 24V, 26V, 69H, 82Q, 84V, 86I, 123K, 179E, 191A, 192D
CDD
cd01415 (SAICAR_synt_PurC)

16Y

ATP binding site
7I, 8Y, 10G, 11K, 13K, 15L, 16Y, 24V, 26V, 69H, 82Q, 84V, 86I, 123K, 179E, 191A, 192D
CDD
cd01415 (SAICAR_synt_PurC)

24V

ATP binding site
7I, 8Y, 10G, 11K, 13K, 15L, 16Y, 24V, 26V, 69H, 82Q, 84V, 86I, 123K, 179E, 191A, 192D
CDD
cd01415 (SAICAR_synt_PurC)

26V

ATP binding site
7I, 8Y, 10G, 11K, 13K, 15L, 16Y, 24V, 26V, 69H, 82Q, 84V, 86I, 123K, 179E, 191A, 192D
CDD
cd01415 (SAICAR_synt_PurC)

69H

ATP binding site
7I, 8Y, 10G, 11K, 13K, 15L, 16Y, 24V, 26V, 69H, 82Q, 84V, 86I, 123K, 179E, 191A, 192D
CDD
cd01415 (SAICAR_synt_PurC)

82Q

ATP binding site
7I, 8Y, 10G, 11K, 13K, 15L, 16Y, 24V, 26V, 69H, 82Q, 84V, 86I, 123K, 179E, 191A, 192D
CDD
cd01415 (SAICAR_synt_PurC)

84V

ATP binding site
7I, 8Y, 10G, 11K, 13K, 15L, 16Y, 24V, 26V, 69H, 82Q, 84V, 86I, 123K, 179E, 191A, 192D
CDD
cd01415 (SAICAR_synt_PurC)

86I

ATP binding site
7I, 8Y, 10G, 11K, 13K, 15L, 16Y, 24V, 26V, 69H, 82Q, 84V, 86I, 123K, 179E, 191A, 192D
CDD
cd01415 (SAICAR_synt_PurC)

123K

ATP binding site
7I, 8Y, 10G, 11K, 13K, 15L, 16Y, 24V, 26V, 69H, 82Q, 84V, 86I, 123K, 179E, 191A, 192D
CDD
cd01415 (SAICAR_synt_PurC)

179E

ATP binding site
7I, 8Y, 10G, 11K, 13K, 15L, 16Y, 24V, 26V, 69H, 82Q, 84V, 86I, 123K, 179E, 191A, 192D
CDD
cd01415 (SAICAR_synt_PurC)

191A

ATP binding site
7I, 8Y, 10G, 11K, 13K, 15L, 16Y, 24V, 26V, 69H, 82Q, 84V, 86I, 123K, 179E, 191A, 192D
CDD
cd01415 (SAICAR_synt_PurC)

192D

ATP binding site
7I, 8Y, 10G, 11K, 13K, 15L, 16Y, 24V, 26V, 69H, 82Q, 84V, 86I, 123K, 179E, 191A, 192D
CDD
cd01415 (SAICAR_synt_PurC)
active site cd01415

8Y

active site
8Y, 10G, 11K, 12A, 13K, 15L, 24V, 36N, 70F, 81C, 82Q, 83R, 84V, 86I, 90E, 92I, 94R, 98A, 99G, 100S, 121C, 123K, 129D, 175D, 176F, 177K, 179E, 192D, 197D, 198T, 199C, 200R
CDD
cd01415 (SAICAR_synt_PurC)

10G

active site
8Y, 10G, 11K, 12A, 13K, 15L, 24V, 36N, 70F, 81C, 82Q, 83R, 84V, 86I, 90E, 92I, 94R, 98A, 99G, 100S, 121C, 123K, 129D, 175D, 176F, 177K, 179E, 192D, 197D, 198T, 199C, 200R
CDD
cd01415 (SAICAR_synt_PurC)

11K

active site
8Y, 10G, 11K, 12A, 13K, 15L, 24V, 36N, 70F, 81C, 82Q, 83R, 84V, 86I, 90E, 92I, 94R, 98A, 99G, 100S, 121C, 123K, 129D, 175D, 176F, 177K, 179E, 192D, 197D, 198T, 199C, 200R
CDD
cd01415 (SAICAR_synt_PurC)

12A

active site
8Y, 10G, 11K, 12A, 13K, 15L, 24V, 36N, 70F, 81C, 82Q, 83R, 84V, 86I, 90E, 92I, 94R, 98A, 99G, 100S, 121C, 123K, 129D, 175D, 176F, 177K, 179E, 192D, 197D, 198T, 199C, 200R
CDD
cd01415 (SAICAR_synt_PurC)

13K

active site
8Y, 10G, 11K, 12A, 13K, 15L, 24V, 36N, 70F, 81C, 82Q, 83R, 84V, 86I, 90E, 92I, 94R, 98A, 99G, 100S, 121C, 123K, 129D, 175D, 176F, 177K, 179E, 192D, 197D, 198T, 199C, 200R
CDD
cd01415 (SAICAR_synt_PurC)

15L

active site
8Y, 10G, 11K, 12A, 13K, 15L, 24V, 36N, 70F, 81C, 82Q, 83R, 84V, 86I, 90E, 92I, 94R, 98A, 99G, 100S, 121C, 123K, 129D, 175D, 176F, 177K, 179E, 192D, 197D, 198T, 199C, 200R
CDD
cd01415 (SAICAR_synt_PurC)

24V

active site
8Y, 10G, 11K, 12A, 13K, 15L, 24V, 36N, 70F, 81C, 82Q, 83R, 84V, 86I, 90E, 92I, 94R, 98A, 99G, 100S, 121C, 123K, 129D, 175D, 176F, 177K, 179E, 192D, 197D, 198T, 199C, 200R
CDD
cd01415 (SAICAR_synt_PurC)

36N

active site
8Y, 10G, 11K, 12A, 13K, 15L, 24V, 36N, 70F, 81C, 82Q, 83R, 84V, 86I, 90E, 92I, 94R, 98A, 99G, 100S, 121C, 123K, 129D, 175D, 176F, 177K, 179E, 192D, 197D, 198T, 199C, 200R
CDD
cd01415 (SAICAR_synt_PurC)

70F

active site
8Y, 10G, 11K, 12A, 13K, 15L, 24V, 36N, 70F, 81C, 82Q, 83R, 84V, 86I, 90E, 92I, 94R, 98A, 99G, 100S, 121C, 123K, 129D, 175D, 176F, 177K, 179E, 192D, 197D, 198T, 199C, 200R
CDD
cd01415 (SAICAR_synt_PurC)

81C

active site
8Y, 10G, 11K, 12A, 13K, 15L, 24V, 36N, 70F, 81C, 82Q, 83R, 84V, 86I, 90E, 92I, 94R, 98A, 99G, 100S, 121C, 123K, 129D, 175D, 176F, 177K, 179E, 192D, 197D, 198T, 199C, 200R
CDD
cd01415 (SAICAR_synt_PurC)

82Q

active site
8Y, 10G, 11K, 12A, 13K, 15L, 24V, 36N, 70F, 81C, 82Q, 83R, 84V, 86I, 90E, 92I, 94R, 98A, 99G, 100S, 121C, 123K, 129D, 175D, 176F, 177K, 179E, 192D, 197D, 198T, 199C, 200R
CDD
cd01415 (SAICAR_synt_PurC)

83R

active site
8Y, 10G, 11K, 12A, 13K, 15L, 24V, 36N, 70F, 81C, 82Q, 83R, 84V, 86I, 90E, 92I, 94R, 98A, 99G, 100S, 121C, 123K, 129D, 175D, 176F, 177K, 179E, 192D, 197D, 198T, 199C, 200R
CDD
cd01415 (SAICAR_synt_PurC)

84V

active site
8Y, 10G, 11K, 12A, 13K, 15L, 24V, 36N, 70F, 81C, 82Q, 83R, 84V, 86I, 90E, 92I, 94R, 98A, 99G, 100S, 121C, 123K, 129D, 175D, 176F, 177K, 179E, 192D, 197D, 198T, 199C, 200R
CDD
cd01415 (SAICAR_synt_PurC)

86I

active site
8Y, 10G, 11K, 12A, 13K, 15L, 24V, 36N, 70F, 81C, 82Q, 83R, 84V, 86I, 90E, 92I, 94R, 98A, 99G, 100S, 121C, 123K, 129D, 175D, 176F, 177K, 179E, 192D, 197D, 198T, 199C, 200R
CDD
cd01415 (SAICAR_synt_PurC)

90E

active site
8Y, 10G, 11K, 12A, 13K, 15L, 24V, 36N, 70F, 81C, 82Q, 83R, 84V, 86I, 90E, 92I, 94R, 98A, 99G, 100S, 121C, 123K, 129D, 175D, 176F, 177K, 179E, 192D, 197D, 198T, 199C, 200R
CDD
cd01415 (SAICAR_synt_PurC)

92I

active site
8Y, 10G, 11K, 12A, 13K, 15L, 24V, 36N, 70F, 81C, 82Q, 83R, 84V, 86I, 90E, 92I, 94R, 98A, 99G, 100S, 121C, 123K, 129D, 175D, 176F, 177K, 179E, 192D, 197D, 198T, 199C, 200R
CDD
cd01415 (SAICAR_synt_PurC)

94R

active site
8Y, 10G, 11K, 12A, 13K, 15L, 24V, 36N, 70F, 81C, 82Q, 83R, 84V, 86I, 90E, 92I, 94R, 98A, 99G, 100S, 121C, 123K, 129D, 175D, 176F, 177K, 179E, 192D, 197D, 198T, 199C, 200R
CDD
cd01415 (SAICAR_synt_PurC)

98A

active site
8Y, 10G, 11K, 12A, 13K, 15L, 24V, 36N, 70F, 81C, 82Q, 83R, 84V, 86I, 90E, 92I, 94R, 98A, 99G, 100S, 121C, 123K, 129D, 175D, 176F, 177K, 179E, 192D, 197D, 198T, 199C, 200R
CDD
cd01415 (SAICAR_synt_PurC)

99G

active site
8Y, 10G, 11K, 12A, 13K, 15L, 24V, 36N, 70F, 81C, 82Q, 83R, 84V, 86I, 90E, 92I, 94R, 98A, 99G, 100S, 121C, 123K, 129D, 175D, 176F, 177K, 179E, 192D, 197D, 198T, 199C, 200R
CDD
cd01415 (SAICAR_synt_PurC)

100S

active site
8Y, 10G, 11K, 12A, 13K, 15L, 24V, 36N, 70F, 81C, 82Q, 83R, 84V, 86I, 90E, 92I, 94R, 98A, 99G, 100S, 121C, 123K, 129D, 175D, 176F, 177K, 179E, 192D, 197D, 198T, 199C, 200R
CDD
cd01415 (SAICAR_synt_PurC)

121C

active site
8Y, 10G, 11K, 12A, 13K, 15L, 24V, 36N, 70F, 81C, 82Q, 83R, 84V, 86I, 90E, 92I, 94R, 98A, 99G, 100S, 121C, 123K, 129D, 175D, 176F, 177K, 179E, 192D, 197D, 198T, 199C, 200R
CDD
cd01415 (SAICAR_synt_PurC)

123K

active site
8Y, 10G, 11K, 12A, 13K, 15L, 24V, 36N, 70F, 81C, 82Q, 83R, 84V, 86I, 90E, 92I, 94R, 98A, 99G, 100S, 121C, 123K, 129D, 175D, 176F, 177K, 179E, 192D, 197D, 198T, 199C, 200R
CDD
cd01415 (SAICAR_synt_PurC)

129D

active site
8Y, 10G, 11K, 12A, 13K, 15L, 24V, 36N, 70F, 81C, 82Q, 83R, 84V, 86I, 90E, 92I, 94R, 98A, 99G, 100S, 121C, 123K, 129D, 175D, 176F, 177K, 179E, 192D, 197D, 198T, 199C, 200R
CDD
cd01415 (SAICAR_synt_PurC)

175D

active site
8Y, 10G, 11K, 12A, 13K, 15L, 24V, 36N, 70F, 81C, 82Q, 83R, 84V, 86I, 90E, 92I, 94R, 98A, 99G, 100S, 121C, 123K, 129D, 175D, 176F, 177K, 179E, 192D, 197D, 198T, 199C, 200R
CDD
cd01415 (SAICAR_synt_PurC)

176F

active site
8Y, 10G, 11K, 12A, 13K, 15L, 24V, 36N, 70F, 81C, 82Q, 83R, 84V, 86I, 90E, 92I, 94R, 98A, 99G, 100S, 121C, 123K, 129D, 175D, 176F, 177K, 179E, 192D, 197D, 198T, 199C, 200R
CDD
cd01415 (SAICAR_synt_PurC)

177K

active site
8Y, 10G, 11K, 12A, 13K, 15L, 24V, 36N, 70F, 81C, 82Q, 83R, 84V, 86I, 90E, 92I, 94R, 98A, 99G, 100S, 121C, 123K, 129D, 175D, 176F, 177K, 179E, 192D, 197D, 198T, 199C, 200R
CDD
cd01415 (SAICAR_synt_PurC)

179E

active site
8Y, 10G, 11K, 12A, 13K, 15L, 24V, 36N, 70F, 81C, 82Q, 83R, 84V, 86I, 90E, 92I, 94R, 98A, 99G, 100S, 121C, 123K, 129D, 175D, 176F, 177K, 179E, 192D, 197D, 198T, 199C, 200R
CDD
cd01415 (SAICAR_synt_PurC)

192D

active site
8Y, 10G, 11K, 12A, 13K, 15L, 24V, 36N, 70F, 81C, 82Q, 83R, 84V, 86I, 90E, 92I, 94R, 98A, 99G, 100S, 121C, 123K, 129D, 175D, 176F, 177K, 179E, 192D, 197D, 198T, 199C, 200R
CDD
cd01415 (SAICAR_synt_PurC)

197D

active site
8Y, 10G, 11K, 12A, 13K, 15L, 24V, 36N, 70F, 81C, 82Q, 83R, 84V, 86I, 90E, 92I, 94R, 98A, 99G, 100S, 121C, 123K, 129D, 175D, 176F, 177K, 179E, 192D, 197D, 198T, 199C, 200R
CDD
cd01415 (SAICAR_synt_PurC)

198T

active site
8Y, 10G, 11K, 12A, 13K, 15L, 24V, 36N, 70F, 81C, 82Q, 83R, 84V, 86I, 90E, 92I, 94R, 98A, 99G, 100S, 121C, 123K, 129D, 175D, 176F, 177K, 179E, 192D, 197D, 198T, 199C, 200R
CDD
cd01415 (SAICAR_synt_PurC)

199C

active site
8Y, 10G, 11K, 12A, 13K, 15L, 24V, 36N, 70F, 81C, 82Q, 83R, 84V, 86I, 90E, 92I, 94R, 98A, 99G, 100S, 121C, 123K, 129D, 175D, 176F, 177K, 179E, 192D, 197D, 198T, 199C, 200R
CDD
cd01415 (SAICAR_synt_PurC)

200R

active site
8Y, 10G, 11K, 12A, 13K, 15L, 24V, 36N, 70F, 81C, 82Q, 83R, 84V, 86I, 90E, 92I, 94R, 98A, 99G, 100S, 121C, 123K, 129D, 175D, 176F, 177K, 179E, 192D, 197D, 198T, 199C, 200R
CDD
cd01415 (SAICAR_synt_PurC)
substrate binding ...

36N

substrate binding site
36N, 90E, 92I, 94R, 98A, 99G, 100S, 121C, 129D, 175D, 176F, 177K, 197D, 198T, 199C, 200R
CDD
cd01415 (SAICAR_synt_PurC)

90E

substrate binding site
36N, 90E, 92I, 94R, 98A, 99G, 100S, 121C, 129D, 175D, 176F, 177K, 197D, 198T, 199C, 200R
CDD
cd01415 (SAICAR_synt_PurC)

92I

substrate binding site
36N, 90E, 92I, 94R, 98A, 99G, 100S, 121C, 129D, 175D, 176F, 177K, 197D, 198T, 199C, 200R
CDD
cd01415 (SAICAR_synt_PurC)

94R

substrate binding site
36N, 90E, 92I, 94R, 98A, 99G, 100S, 121C, 129D, 175D, 176F, 177K, 197D, 198T, 199C, 200R
CDD
cd01415 (SAICAR_synt_PurC)

98A

substrate binding site
36N, 90E, 92I, 94R, 98A, 99G, 100S, 121C, 129D, 175D, 176F, 177K, 197D, 198T, 199C, 200R
CDD
cd01415 (SAICAR_synt_PurC)

99G

substrate binding site
36N, 90E, 92I, 94R, 98A, 99G, 100S, 121C, 129D, 175D, 176F, 177K, 197D, 198T, 199C, 200R
CDD
cd01415 (SAICAR_synt_PurC)

100S

substrate binding site
36N, 90E, 92I, 94R, 98A, 99G, 100S, 121C, 129D, 175D, 176F, 177K, 197D, 198T, 199C, 200R
CDD
cd01415 (SAICAR_synt_PurC)

121C

substrate binding site
36N, 90E, 92I, 94R, 98A, 99G, 100S, 121C, 129D, 175D, 176F, 177K, 197D, 198T, 199C, 200R
CDD
cd01415 (SAICAR_synt_PurC)

129D

substrate binding site
36N, 90E, 92I, 94R, 98A, 99G, 100S, 121C, 129D, 175D, 176F, 177K, 197D, 198T, 199C, 200R
CDD
cd01415 (SAICAR_synt_PurC)

175D

substrate binding site
36N, 90E, 92I, 94R, 98A, 99G, 100S, 121C, 129D, 175D, 176F, 177K, 197D, 198T, 199C, 200R
CDD
cd01415 (SAICAR_synt_PurC)

176F

substrate binding site
36N, 90E, 92I, 94R, 98A, 99G, 100S, 121C, 129D, 175D, 176F, 177K, 197D, 198T, 199C, 200R
CDD
cd01415 (SAICAR_synt_PurC)

177K

substrate binding site
36N, 90E, 92I, 94R, 98A, 99G, 100S, 121C, 129D, 175D, 176F, 177K, 197D, 198T, 199C, 200R
CDD
cd01415 (SAICAR_synt_PurC)

197D

substrate binding site
36N, 90E, 92I, 94R, 98A, 99G, 100S, 121C, 129D, 175D, 176F, 177K, 197D, 198T, 199C, 200R
CDD
cd01415 (SAICAR_synt_PurC)

198T

substrate binding site
36N, 90E, 92I, 94R, 98A, 99G, 100S, 121C, 129D, 175D, 176F, 177K, 197D, 198T, 199C, 200R
CDD
cd01415 (SAICAR_synt_PurC)

199C

substrate binding site
36N, 90E, 92I, 94R, 98A, 99G, 100S, 121C, 129D, 175D, 176F, 177K, 197D, 198T, 199C, 200R
CDD
cd01415 (SAICAR_synt_PurC)

200R

substrate binding site
36N, 90E, 92I, 94R, 98A, 99G, 100S, 121C, 129D, 175D, 176F, 177K, 197D, 198T, 199C, 200R
CDD
cd01415 (SAICAR_synt_PurC)

GO term prediction

Biological Process

GO:0006164 purine nucleotide biosynthetic process
GO:0009236 cobalamin biosynthetic process

Molecular Function

GO:0004639 phosphoribosylaminoimidazolesuccinocarboxamide synthase activity

Cellular Component