25586_FusoPortal_Gene_161

Protein

25586_FusoPortal_Gene_161

Length

598 amino acids

Protein family membership

Bifunctional CTP:phosphocholine cytidylyltransferase/choline kinase (IPR017190)

Homologous superfamilies

Homologous superfamily
2 - 71
Winged helix-like DNA-binding domain superfamily (IPR036388)
Homologous superfamily
4 - 69
Winged helix DNA-binding domain superfamily (IPR036390)
72 - 295
Nucleotide-diphospho-sugar transferases (IPR029044)
307 - 592
Protein kinase-like domain superfamily (IPR011009)

1 100 200 300 400 500 598

Domains and repeats

Domain
76 - 194
MobA-like NTP transferase (IPR025877)

1 100 200 300 400 500 598

Detailed signature matches

IPR036388

Winged helix-like DNA-binding domain superfamily
1. G3DSA:1.10.10.10
  
  2 - 71
  
  GENE3D
  G3DSA:1.10.10.10 (G3DSA:1.10.10.10)
IPR036390

Winged helix DNA-binding domain superfamily
1. SSF46785 ("Winged h...)
  
  4 - 69
  
  SUPERFAMILY
  SSF46785 ("Winged helix" DNA-binding domain)
IPR029044

Nucleotide-diphospho-sugar transferases
1. G3DSA:3.90.55...
  
  72 - 295
  
  GENE3D
  G3DSA:3.90.550.10 (G3DSA:3.90.550.10)
2. SSF53448 (Nucleotid...)
  
  75 - 295
  
  SUPERFAMILY
  SSF53448 (Nucleotide-diphospho-sugar transferases)
IPR011009

Protein kinase-like domain superfamily
1. SSF56112 (Protein k...)
  
  307 - 592
  
  SUPERFAMILY
  SSF56112 (Protein kinase-like (PK-like))
IPR017190

Bifunctional CTP:phosphocholine cytidylyltransferase/choline kinase
1. PIRSF037383 (LicCA)
  
  1 - 598
  
  PIRSF
  PIRSF037383 (LicCA)
IPR025877

MobA-like NTP transferase
1. PF12804 (NTP_transf_3)
  
  76 - 194
  
  Pfam
  PF12804 (NTP_transf_3)

no IPR

Unintegrated signatures

G3DSA:3.90.12...

403 - 598

GENE3D
G3DSA:3.90.1200.10 (G3DSA:3.90.1200.10)
PF01633 (Choline_ki...)

347 - 542

Pfam
PF01633 (Choline_kinase)
PF13412 (HTH_24)

3 - 44

Pfam
PF13412 (HTH_24)
PTHR22603 (CHOLINE/...)

201 - 596

PANTHER
PTHR22603 (CHOLINE/ETHANOALAMINE KINASE)
PTHR22603:SF66 (ETH...)

201 - 596

PANTHER
PTHR22603:SF66 (ETHANOLAMINE KINASE 2)
cd05151 (ChoK-like)

326 - 524

CDD
cd05151 (ChoK-like)

Residue annotation

ATP binding site c...

332L

ATP binding site
332L, 337N, 339N, 350V, 352R, 381A, 395A, 396K, 397Y, 398I, 400R, 401A, 402E, 489E, 492I, 501I, 502D
CDD
cd05151 (ChoK-like)

337N

ATP binding site
332L, 337N, 339N, 350V, 352R, 381A, 395A, 396K, 397Y, 398I, 400R, 401A, 402E, 489E, 492I, 501I, 502D
CDD
cd05151 (ChoK-like)

339N

ATP binding site
332L, 337N, 339N, 350V, 352R, 381A, 395A, 396K, 397Y, 398I, 400R, 401A, 402E, 489E, 492I, 501I, 502D
CDD
cd05151 (ChoK-like)

350V

ATP binding site
332L, 337N, 339N, 350V, 352R, 381A, 395A, 396K, 397Y, 398I, 400R, 401A, 402E, 489E, 492I, 501I, 502D
CDD
cd05151 (ChoK-like)

352R

ATP binding site
332L, 337N, 339N, 350V, 352R, 381A, 395A, 396K, 397Y, 398I, 400R, 401A, 402E, 489E, 492I, 501I, 502D
CDD
cd05151 (ChoK-like)

381A

ATP binding site
332L, 337N, 339N, 350V, 352R, 381A, 395A, 396K, 397Y, 398I, 400R, 401A, 402E, 489E, 492I, 501I, 502D
CDD
cd05151 (ChoK-like)

395A

ATP binding site
332L, 337N, 339N, 350V, 352R, 381A, 395A, 396K, 397Y, 398I, 400R, 401A, 402E, 489E, 492I, 501I, 502D
CDD
cd05151 (ChoK-like)

396K

ATP binding site
332L, 337N, 339N, 350V, 352R, 381A, 395A, 396K, 397Y, 398I, 400R, 401A, 402E, 489E, 492I, 501I, 502D
CDD
cd05151 (ChoK-like)

397Y

ATP binding site
332L, 337N, 339N, 350V, 352R, 381A, 395A, 396K, 397Y, 398I, 400R, 401A, 402E, 489E, 492I, 501I, 502D
CDD
cd05151 (ChoK-like)

398I

ATP binding site
332L, 337N, 339N, 350V, 352R, 381A, 395A, 396K, 397Y, 398I, 400R, 401A, 402E, 489E, 492I, 501I, 502D
CDD
cd05151 (ChoK-like)

400R

ATP binding site
332L, 337N, 339N, 350V, 352R, 381A, 395A, 396K, 397Y, 398I, 400R, 401A, 402E, 489E, 492I, 501I, 502D
CDD
cd05151 (ChoK-like)

401A

ATP binding site
332L, 337N, 339N, 350V, 352R, 381A, 395A, 396K, 397Y, 398I, 400R, 401A, 402E, 489E, 492I, 501I, 502D
CDD
cd05151 (ChoK-like)

402E

ATP binding site
332L, 337N, 339N, 350V, 352R, 381A, 395A, 396K, 397Y, 398I, 400R, 401A, 402E, 489E, 492I, 501I, 502D
CDD
cd05151 (ChoK-like)

489E

ATP binding site
332L, 337N, 339N, 350V, 352R, 381A, 395A, 396K, 397Y, 398I, 400R, 401A, 402E, 489E, 492I, 501I, 502D
CDD
cd05151 (ChoK-like)

492I

ATP binding site
332L, 337N, 339N, 350V, 352R, 381A, 395A, 396K, 397Y, 398I, 400R, 401A, 402E, 489E, 492I, 501I, 502D
CDD
cd05151 (ChoK-like)

501I

ATP binding site
332L, 337N, 339N, 350V, 352R, 381A, 395A, 396K, 397Y, 398I, 400R, 401A, 402E, 489E, 492I, 501I, 502D
CDD
cd05151 (ChoK-like)

502D

ATP binding site
332L, 337N, 339N, 350V, 352R, 381A, 395A, 396K, 397Y, 398I, 400R, 401A, 402E, 489E, 492I, 501I, 502D
CDD
cd05151 (ChoK-like)
active site cd05151

332L

active site
332L, 334G, 335M, 336T, 337N, 339N, 350V, 352R, 381A, 395A, 396K, 397Y, 398I, 400R, 401A, 402E, 485D, 487V, 489E, 490N, 492I, 501I, 502D, 505Y, 521E
CDD
cd05151 (ChoK-like)

334G

active site
332L, 334G, 335M, 336T, 337N, 339N, 350V, 352R, 381A, 395A, 396K, 397Y, 398I, 400R, 401A, 402E, 485D, 487V, 489E, 490N, 492I, 501I, 502D, 505Y, 521E
CDD
cd05151 (ChoK-like)

335M

active site
332L, 334G, 335M, 336T, 337N, 339N, 350V, 352R, 381A, 395A, 396K, 397Y, 398I, 400R, 401A, 402E, 485D, 487V, 489E, 490N, 492I, 501I, 502D, 505Y, 521E
CDD
cd05151 (ChoK-like)

336T

active site
332L, 334G, 335M, 336T, 337N, 339N, 350V, 352R, 381A, 395A, 396K, 397Y, 398I, 400R, 401A, 402E, 485D, 487V, 489E, 490N, 492I, 501I, 502D, 505Y, 521E
CDD
cd05151 (ChoK-like)

337N

active site
332L, 334G, 335M, 336T, 337N, 339N, 350V, 352R, 381A, 395A, 396K, 397Y, 398I, 400R, 401A, 402E, 485D, 487V, 489E, 490N, 492I, 501I, 502D, 505Y, 521E
CDD
cd05151 (ChoK-like)

339N

active site
332L, 334G, 335M, 336T, 337N, 339N, 350V, 352R, 381A, 395A, 396K, 397Y, 398I, 400R, 401A, 402E, 485D, 487V, 489E, 490N, 492I, 501I, 502D, 505Y, 521E
CDD
cd05151 (ChoK-like)

350V

active site
332L, 334G, 335M, 336T, 337N, 339N, 350V, 352R, 381A, 395A, 396K, 397Y, 398I, 400R, 401A, 402E, 485D, 487V, 489E, 490N, 492I, 501I, 502D, 505Y, 521E
CDD
cd05151 (ChoK-like)

352R

active site
332L, 334G, 335M, 336T, 337N, 339N, 350V, 352R, 381A, 395A, 396K, 397Y, 398I, 400R, 401A, 402E, 485D, 487V, 489E, 490N, 492I, 501I, 502D, 505Y, 521E
CDD
cd05151 (ChoK-like)

381A

active site
332L, 334G, 335M, 336T, 337N, 339N, 350V, 352R, 381A, 395A, 396K, 397Y, 398I, 400R, 401A, 402E, 485D, 487V, 489E, 490N, 492I, 501I, 502D, 505Y, 521E
CDD
cd05151 (ChoK-like)

395A

active site
332L, 334G, 335M, 336T, 337N, 339N, 350V, 352R, 381A, 395A, 396K, 397Y, 398I, 400R, 401A, 402E, 485D, 487V, 489E, 490N, 492I, 501I, 502D, 505Y, 521E
CDD
cd05151 (ChoK-like)

396K

active site
332L, 334G, 335M, 336T, 337N, 339N, 350V, 352R, 381A, 395A, 396K, 397Y, 398I, 400R, 401A, 402E, 485D, 487V, 489E, 490N, 492I, 501I, 502D, 505Y, 521E
CDD
cd05151 (ChoK-like)

397Y

active site
332L, 334G, 335M, 336T, 337N, 339N, 350V, 352R, 381A, 395A, 396K, 397Y, 398I, 400R, 401A, 402E, 485D, 487V, 489E, 490N, 492I, 501I, 502D, 505Y, 521E
CDD
cd05151 (ChoK-like)

398I

active site
332L, 334G, 335M, 336T, 337N, 339N, 350V, 352R, 381A, 395A, 396K, 397Y, 398I, 400R, 401A, 402E, 485D, 487V, 489E, 490N, 492I, 501I, 502D, 505Y, 521E
CDD
cd05151 (ChoK-like)

400R

active site
332L, 334G, 335M, 336T, 337N, 339N, 350V, 352R, 381A, 395A, 396K, 397Y, 398I, 400R, 401A, 402E, 485D, 487V, 489E, 490N, 492I, 501I, 502D, 505Y, 521E
CDD
cd05151 (ChoK-like)

401A

active site
332L, 334G, 335M, 336T, 337N, 339N, 350V, 352R, 381A, 395A, 396K, 397Y, 398I, 400R, 401A, 402E, 485D, 487V, 489E, 490N, 492I, 501I, 502D, 505Y, 521E
CDD
cd05151 (ChoK-like)

402E

active site
332L, 334G, 335M, 336T, 337N, 339N, 350V, 352R, 381A, 395A, 396K, 397Y, 398I, 400R, 401A, 402E, 485D, 487V, 489E, 490N, 492I, 501I, 502D, 505Y, 521E
CDD
cd05151 (ChoK-like)

485D

active site
332L, 334G, 335M, 336T, 337N, 339N, 350V, 352R, 381A, 395A, 396K, 397Y, 398I, 400R, 401A, 402E, 485D, 487V, 489E, 490N, 492I, 501I, 502D, 505Y, 521E
CDD
cd05151 (ChoK-like)

487V

active site
332L, 334G, 335M, 336T, 337N, 339N, 350V, 352R, 381A, 395A, 396K, 397Y, 398I, 400R, 401A, 402E, 485D, 487V, 489E, 490N, 492I, 501I, 502D, 505Y, 521E
CDD
cd05151 (ChoK-like)

489E

active site
332L, 334G, 335M, 336T, 337N, 339N, 350V, 352R, 381A, 395A, 396K, 397Y, 398I, 400R, 401A, 402E, 485D, 487V, 489E, 490N, 492I, 501I, 502D, 505Y, 521E
CDD
cd05151 (ChoK-like)

490N

active site
332L, 334G, 335M, 336T, 337N, 339N, 350V, 352R, 381A, 395A, 396K, 397Y, 398I, 400R, 401A, 402E, 485D, 487V, 489E, 490N, 492I, 501I, 502D, 505Y, 521E
CDD
cd05151 (ChoK-like)

492I

active site
332L, 334G, 335M, 336T, 337N, 339N, 350V, 352R, 381A, 395A, 396K, 397Y, 398I, 400R, 401A, 402E, 485D, 487V, 489E, 490N, 492I, 501I, 502D, 505Y, 521E
CDD
cd05151 (ChoK-like)

501I

active site
332L, 334G, 335M, 336T, 337N, 339N, 350V, 352R, 381A, 395A, 396K, 397Y, 398I, 400R, 401A, 402E, 485D, 487V, 489E, 490N, 492I, 501I, 502D, 505Y, 521E
CDD
cd05151 (ChoK-like)

502D

active site
332L, 334G, 335M, 336T, 337N, 339N, 350V, 352R, 381A, 395A, 396K, 397Y, 398I, 400R, 401A, 402E, 485D, 487V, 489E, 490N, 492I, 501I, 502D, 505Y, 521E
CDD
cd05151 (ChoK-like)

505Y

active site
332L, 334G, 335M, 336T, 337N, 339N, 350V, 352R, 381A, 395A, 396K, 397Y, 398I, 400R, 401A, 402E, 485D, 487V, 489E, 490N, 492I, 501I, 502D, 505Y, 521E
CDD
cd05151 (ChoK-like)

521E

active site
332L, 334G, 335M, 336T, 337N, 339N, 350V, 352R, 381A, 395A, 396K, 397Y, 398I, 400R, 401A, 402E, 485D, 487V, 489E, 490N, 492I, 501I, 502D, 505Y, 521E
CDD
cd05151 (ChoK-like)
substrate binding ...

334G

substrate binding site
334G, 335M, 336T, 485D, 487V, 490N, 505Y, 521E
CDD
cd05151 (ChoK-like)

335M

substrate binding site
334G, 335M, 336T, 485D, 487V, 490N, 505Y, 521E
CDD
cd05151 (ChoK-like)

336T

substrate binding site
334G, 335M, 336T, 485D, 487V, 490N, 505Y, 521E
CDD
cd05151 (ChoK-like)

485D

substrate binding site
334G, 335M, 336T, 485D, 487V, 490N, 505Y, 521E
CDD
cd05151 (ChoK-like)

487V

substrate binding site
334G, 335M, 336T, 485D, 487V, 490N, 505Y, 521E
CDD
cd05151 (ChoK-like)

490N

substrate binding site
334G, 335M, 336T, 485D, 487V, 490N, 505Y, 521E
CDD
cd05151 (ChoK-like)

505Y

substrate binding site
334G, 335M, 336T, 485D, 487V, 490N, 505Y, 521E
CDD
cd05151 (ChoK-like)

521E

substrate binding site
334G, 335M, 336T, 485D, 487V, 490N, 505Y, 521E
CDD
cd05151 (ChoK-like)
dimer interface cd...

365K

dimer interface
365K, 368N, 369Y, 372Q, 373L, 383I, 384M, 385H, 386F, 477I
CDD
cd05151 (ChoK-like)

368N

dimer interface
365K, 368N, 369Y, 372Q, 373L, 383I, 384M, 385H, 386F, 477I
CDD
cd05151 (ChoK-like)

369Y

dimer interface
365K, 368N, 369Y, 372Q, 373L, 383I, 384M, 385H, 386F, 477I
CDD
cd05151 (ChoK-like)

372Q

dimer interface
365K, 368N, 369Y, 372Q, 373L, 383I, 384M, 385H, 386F, 477I
CDD
cd05151 (ChoK-like)

373L

dimer interface
365K, 368N, 369Y, 372Q, 373L, 383I, 384M, 385H, 386F, 477I
CDD
cd05151 (ChoK-like)

383I

dimer interface
365K, 368N, 369Y, 372Q, 373L, 383I, 384M, 385H, 386F, 477I
CDD
cd05151 (ChoK-like)

384M

dimer interface
365K, 368N, 369Y, 372Q, 373L, 383I, 384M, 385H, 386F, 477I
CDD
cd05151 (ChoK-like)

385H

dimer interface
365K, 368N, 369Y, 372Q, 373L, 383I, 384M, 385H, 386F, 477I
CDD
cd05151 (ChoK-like)

386F

dimer interface
365K, 368N, 369Y, 372Q, 373L, 383I, 384M, 385H, 386F, 477I
CDD
cd05151 (ChoK-like)

477I

dimer interface
365K, 368N, 369Y, 372Q, 373L, 383I, 384M, 385H, 386F, 477I
CDD
cd05151 (ChoK-like)

GO term prediction

Biological Process

None predicted.

Molecular Function

None predicted.

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features

25586_FusoPortal_Gene_161

Protein family membership

Homologous superfamilies

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component