25586_FusoPortal_Gene_1734

Protein

25586_FusoPortal_Gene_1734

Length

350 amino acids

Protein family membership

DNA polymerase IV (IPR022880)

Homologous superfamilies

Homologous superfamily
236 - 348
DNA polymerase, Y-family, little finger domain superfamily (IPR036775)

1 50 100 150 200 250 300 350 350

Domains and repeats

Domain
5 - 181
UmuC domain (IPR001126)
231 - 337
DNA polymerase, Y-family, little finger domain (IPR017961)

1 50 100 150 200 250 300 350 350

Detailed signature matches

IPR036775

DNA polymerase, Y-family, little finger domain superfamily
1. SSF100879 (Lesion b...)
  
  236 - 336
  
  SUPERFAMILY
  SSF100879 (Lesion bypass DNA polymerase (Y-family), little finger domain)
2. G3DSA:3.30.14...
  
  238 - 348
  
  GENE3D
  G3DSA:3.30.1490.100 (G3DSA:3.30.1490.100)
IPR022880

DNA polymerase IV
1. MF_01113 (DNApol_IV)
  
  2 - 346
  
  HAMAP
  MF_01113 (DNApol_IV)
2. cd03586 (PolY_Pol_I...)
  
  6 - 336
  
  CDD
  cd03586 (PolY_Pol_IV_kappa)
IPR001126

UmuC domain
1. PF00817 (IMS)
  
  9 - 149
  
  Pfam
  PF00817 (IMS)
2. PS50173 (UMUC)
  
  5 - 181
  
  PROSITE profiles
  PS50173 (UMUC)
IPR017961

DNA polymerase, Y-family, little finger domain
1. PF11799 (IMS_C)
  
  231 - 337
  
  Pfam
  PF11799 (IMS_C)

no IPR

Unintegrated signatures

G3DSA:1.10.15...

167 - 237

GENE3D
G3DSA:1.10.150.20 (G3DSA:1.10.150.20)
G3DSA:3.30.70...

115 - 166

GENE3D
G3DSA:3.30.70.270 (G3DSA:3.30.70.270)

37 - 114

GENE3D
G3DSA:3.30.70.270 (G3DSA:3.30.70.270)
PTHR11076 (DNA REPA...)

2 - 334

PANTHER
PTHR11076 (DNA REPAIR POLYMERASE UMUC / TRANSFERASE FAMILY MEMBER)
PTHR11076:SF33 (DNA...)

2 - 334

PANTHER
PTHR11076:SF33 (DNA POLYMERASE KAPPA)
SSF56672 (DNA/RNA p...)

2 - 230

SUPERFAMILY
SSF56672 (DNA/RNA polymerases)

Residue annotation

active site cd03586

9D

active site
9D, 10M, 12A, 13F, 14Y, 38T, 39T, 42Y, 45R, 99D, 152K
CDD
cd03586 (PolY_Pol_IV_kappa)

10M

active site
9D, 10M, 12A, 13F, 14Y, 38T, 39T, 42Y, 45R, 99D, 152K
CDD
cd03586 (PolY_Pol_IV_kappa)

12A

active site
9D, 10M, 12A, 13F, 14Y, 38T, 39T, 42Y, 45R, 99D, 152K
CDD
cd03586 (PolY_Pol_IV_kappa)

13F

active site
9D, 10M, 12A, 13F, 14Y, 38T, 39T, 42Y, 45R, 99D, 152K
CDD
cd03586 (PolY_Pol_IV_kappa)

14Y

active site
9D, 10M, 12A, 13F, 14Y, 38T, 39T, 42Y, 45R, 99D, 152K
CDD
cd03586 (PolY_Pol_IV_kappa)

38T

active site
9D, 10M, 12A, 13F, 14Y, 38T, 39T, 42Y, 45R, 99D, 152K
CDD
cd03586 (PolY_Pol_IV_kappa)

39T

active site
9D, 10M, 12A, 13F, 14Y, 38T, 39T, 42Y, 45R, 99D, 152K
CDD
cd03586 (PolY_Pol_IV_kappa)

42Y

active site
9D, 10M, 12A, 13F, 14Y, 38T, 39T, 42Y, 45R, 99D, 152K
CDD
cd03586 (PolY_Pol_IV_kappa)

45R

active site
9D, 10M, 12A, 13F, 14Y, 38T, 39T, 42Y, 45R, 99D, 152K
CDD
cd03586 (PolY_Pol_IV_kappa)

99D

active site
9D, 10M, 12A, 13F, 14Y, 38T, 39T, 42Y, 45R, 99D, 152K
CDD
cd03586 (PolY_Pol_IV_kappa)

152K

active site
9D, 10M, 12A, 13F, 14Y, 38T, 39T, 42Y, 45R, 99D, 152K
CDD
cd03586 (PolY_Pol_IV_kappa)
DNA binding site c...

34E

DNA binding site
34E, 54K, 97A, 99D, 100E, 145K, 178P, 179G, 180V, 181G, 182K, 183K, 184F, 213K, 214S, 238Y, 239S, 240I, 241G, 242N, 243E, 244E, 245T, 270R, 293Y, 294T, 295K, 296S, 298K, 327R, 328L, 332Y, 335D
CDD
cd03586 (PolY_Pol_IV_kappa)

54K

DNA binding site
34E, 54K, 97A, 99D, 100E, 145K, 178P, 179G, 180V, 181G, 182K, 183K, 184F, 213K, 214S, 238Y, 239S, 240I, 241G, 242N, 243E, 244E, 245T, 270R, 293Y, 294T, 295K, 296S, 298K, 327R, 328L, 332Y, 335D
CDD
cd03586 (PolY_Pol_IV_kappa)

97A

DNA binding site
34E, 54K, 97A, 99D, 100E, 145K, 178P, 179G, 180V, 181G, 182K, 183K, 184F, 213K, 214S, 238Y, 239S, 240I, 241G, 242N, 243E, 244E, 245T, 270R, 293Y, 294T, 295K, 296S, 298K, 327R, 328L, 332Y, 335D
CDD
cd03586 (PolY_Pol_IV_kappa)

99D

DNA binding site
34E, 54K, 97A, 99D, 100E, 145K, 178P, 179G, 180V, 181G, 182K, 183K, 184F, 213K, 214S, 238Y, 239S, 240I, 241G, 242N, 243E, 244E, 245T, 270R, 293Y, 294T, 295K, 296S, 298K, 327R, 328L, 332Y, 335D
CDD
cd03586 (PolY_Pol_IV_kappa)

100E

DNA binding site
34E, 54K, 97A, 99D, 100E, 145K, 178P, 179G, 180V, 181G, 182K, 183K, 184F, 213K, 214S, 238Y, 239S, 240I, 241G, 242N, 243E, 244E, 245T, 270R, 293Y, 294T, 295K, 296S, 298K, 327R, 328L, 332Y, 335D
CDD
cd03586 (PolY_Pol_IV_kappa)

145K

DNA binding site
34E, 54K, 97A, 99D, 100E, 145K, 178P, 179G, 180V, 181G, 182K, 183K, 184F, 213K, 214S, 238Y, 239S, 240I, 241G, 242N, 243E, 244E, 245T, 270R, 293Y, 294T, 295K, 296S, 298K, 327R, 328L, 332Y, 335D
CDD
cd03586 (PolY_Pol_IV_kappa)

178P

DNA binding site
34E, 54K, 97A, 99D, 100E, 145K, 178P, 179G, 180V, 181G, 182K, 183K, 184F, 213K, 214S, 238Y, 239S, 240I, 241G, 242N, 243E, 244E, 245T, 270R, 293Y, 294T, 295K, 296S, 298K, 327R, 328L, 332Y, 335D
CDD
cd03586 (PolY_Pol_IV_kappa)

179G

DNA binding site
34E, 54K, 97A, 99D, 100E, 145K, 178P, 179G, 180V, 181G, 182K, 183K, 184F, 213K, 214S, 238Y, 239S, 240I, 241G, 242N, 243E, 244E, 245T, 270R, 293Y, 294T, 295K, 296S, 298K, 327R, 328L, 332Y, 335D
CDD
cd03586 (PolY_Pol_IV_kappa)

180V

DNA binding site
34E, 54K, 97A, 99D, 100E, 145K, 178P, 179G, 180V, 181G, 182K, 183K, 184F, 213K, 214S, 238Y, 239S, 240I, 241G, 242N, 243E, 244E, 245T, 270R, 293Y, 294T, 295K, 296S, 298K, 327R, 328L, 332Y, 335D
CDD
cd03586 (PolY_Pol_IV_kappa)

181G

DNA binding site
34E, 54K, 97A, 99D, 100E, 145K, 178P, 179G, 180V, 181G, 182K, 183K, 184F, 213K, 214S, 238Y, 239S, 240I, 241G, 242N, 243E, 244E, 245T, 270R, 293Y, 294T, 295K, 296S, 298K, 327R, 328L, 332Y, 335D
CDD
cd03586 (PolY_Pol_IV_kappa)

182K

DNA binding site
34E, 54K, 97A, 99D, 100E, 145K, 178P, 179G, 180V, 181G, 182K, 183K, 184F, 213K, 214S, 238Y, 239S, 240I, 241G, 242N, 243E, 244E, 245T, 270R, 293Y, 294T, 295K, 296S, 298K, 327R, 328L, 332Y, 335D
CDD
cd03586 (PolY_Pol_IV_kappa)

183K

DNA binding site
34E, 54K, 97A, 99D, 100E, 145K, 178P, 179G, 180V, 181G, 182K, 183K, 184F, 213K, 214S, 238Y, 239S, 240I, 241G, 242N, 243E, 244E, 245T, 270R, 293Y, 294T, 295K, 296S, 298K, 327R, 328L, 332Y, 335D
CDD
cd03586 (PolY_Pol_IV_kappa)

184F

DNA binding site
34E, 54K, 97A, 99D, 100E, 145K, 178P, 179G, 180V, 181G, 182K, 183K, 184F, 213K, 214S, 238Y, 239S, 240I, 241G, 242N, 243E, 244E, 245T, 270R, 293Y, 294T, 295K, 296S, 298K, 327R, 328L, 332Y, 335D
CDD
cd03586 (PolY_Pol_IV_kappa)

213K

DNA binding site
34E, 54K, 97A, 99D, 100E, 145K, 178P, 179G, 180V, 181G, 182K, 183K, 184F, 213K, 214S, 238Y, 239S, 240I, 241G, 242N, 243E, 244E, 245T, 270R, 293Y, 294T, 295K, 296S, 298K, 327R, 328L, 332Y, 335D
CDD
cd03586 (PolY_Pol_IV_kappa)

214S

DNA binding site
34E, 54K, 97A, 99D, 100E, 145K, 178P, 179G, 180V, 181G, 182K, 183K, 184F, 213K, 214S, 238Y, 239S, 240I, 241G, 242N, 243E, 244E, 245T, 270R, 293Y, 294T, 295K, 296S, 298K, 327R, 328L, 332Y, 335D
CDD
cd03586 (PolY_Pol_IV_kappa)

238Y

DNA binding site
34E, 54K, 97A, 99D, 100E, 145K, 178P, 179G, 180V, 181G, 182K, 183K, 184F, 213K, 214S, 238Y, 239S, 240I, 241G, 242N, 243E, 244E, 245T, 270R, 293Y, 294T, 295K, 296S, 298K, 327R, 328L, 332Y, 335D
CDD
cd03586 (PolY_Pol_IV_kappa)

239S

DNA binding site
34E, 54K, 97A, 99D, 100E, 145K, 178P, 179G, 180V, 181G, 182K, 183K, 184F, 213K, 214S, 238Y, 239S, 240I, 241G, 242N, 243E, 244E, 245T, 270R, 293Y, 294T, 295K, 296S, 298K, 327R, 328L, 332Y, 335D
CDD
cd03586 (PolY_Pol_IV_kappa)

240I

DNA binding site
34E, 54K, 97A, 99D, 100E, 145K, 178P, 179G, 180V, 181G, 182K, 183K, 184F, 213K, 214S, 238Y, 239S, 240I, 241G, 242N, 243E, 244E, 245T, 270R, 293Y, 294T, 295K, 296S, 298K, 327R, 328L, 332Y, 335D
CDD
cd03586 (PolY_Pol_IV_kappa)

241G

DNA binding site
34E, 54K, 97A, 99D, 100E, 145K, 178P, 179G, 180V, 181G, 182K, 183K, 184F, 213K, 214S, 238Y, 239S, 240I, 241G, 242N, 243E, 244E, 245T, 270R, 293Y, 294T, 295K, 296S, 298K, 327R, 328L, 332Y, 335D
CDD
cd03586 (PolY_Pol_IV_kappa)

242N

DNA binding site
34E, 54K, 97A, 99D, 100E, 145K, 178P, 179G, 180V, 181G, 182K, 183K, 184F, 213K, 214S, 238Y, 239S, 240I, 241G, 242N, 243E, 244E, 245T, 270R, 293Y, 294T, 295K, 296S, 298K, 327R, 328L, 332Y, 335D
CDD
cd03586 (PolY_Pol_IV_kappa)

243E

DNA binding site
34E, 54K, 97A, 99D, 100E, 145K, 178P, 179G, 180V, 181G, 182K, 183K, 184F, 213K, 214S, 238Y, 239S, 240I, 241G, 242N, 243E, 244E, 245T, 270R, 293Y, 294T, 295K, 296S, 298K, 327R, 328L, 332Y, 335D
CDD
cd03586 (PolY_Pol_IV_kappa)

244E

DNA binding site
34E, 54K, 97A, 99D, 100E, 145K, 178P, 179G, 180V, 181G, 182K, 183K, 184F, 213K, 214S, 238Y, 239S, 240I, 241G, 242N, 243E, 244E, 245T, 270R, 293Y, 294T, 295K, 296S, 298K, 327R, 328L, 332Y, 335D
CDD
cd03586 (PolY_Pol_IV_kappa)

245T

DNA binding site
34E, 54K, 97A, 99D, 100E, 145K, 178P, 179G, 180V, 181G, 182K, 183K, 184F, 213K, 214S, 238Y, 239S, 240I, 241G, 242N, 243E, 244E, 245T, 270R, 293Y, 294T, 295K, 296S, 298K, 327R, 328L, 332Y, 335D
CDD
cd03586 (PolY_Pol_IV_kappa)

270R

DNA binding site
34E, 54K, 97A, 99D, 100E, 145K, 178P, 179G, 180V, 181G, 182K, 183K, 184F, 213K, 214S, 238Y, 239S, 240I, 241G, 242N, 243E, 244E, 245T, 270R, 293Y, 294T, 295K, 296S, 298K, 327R, 328L, 332Y, 335D
CDD
cd03586 (PolY_Pol_IV_kappa)

293Y

DNA binding site
34E, 54K, 97A, 99D, 100E, 145K, 178P, 179G, 180V, 181G, 182K, 183K, 184F, 213K, 214S, 238Y, 239S, 240I, 241G, 242N, 243E, 244E, 245T, 270R, 293Y, 294T, 295K, 296S, 298K, 327R, 328L, 332Y, 335D
CDD
cd03586 (PolY_Pol_IV_kappa)

294T

DNA binding site
34E, 54K, 97A, 99D, 100E, 145K, 178P, 179G, 180V, 181G, 182K, 183K, 184F, 213K, 214S, 238Y, 239S, 240I, 241G, 242N, 243E, 244E, 245T, 270R, 293Y, 294T, 295K, 296S, 298K, 327R, 328L, 332Y, 335D
CDD
cd03586 (PolY_Pol_IV_kappa)

295K

DNA binding site
34E, 54K, 97A, 99D, 100E, 145K, 178P, 179G, 180V, 181G, 182K, 183K, 184F, 213K, 214S, 238Y, 239S, 240I, 241G, 242N, 243E, 244E, 245T, 270R, 293Y, 294T, 295K, 296S, 298K, 327R, 328L, 332Y, 335D
CDD
cd03586 (PolY_Pol_IV_kappa)

296S

DNA binding site
34E, 54K, 97A, 99D, 100E, 145K, 178P, 179G, 180V, 181G, 182K, 183K, 184F, 213K, 214S, 238Y, 239S, 240I, 241G, 242N, 243E, 244E, 245T, 270R, 293Y, 294T, 295K, 296S, 298K, 327R, 328L, 332Y, 335D
CDD
cd03586 (PolY_Pol_IV_kappa)

298K

DNA binding site
34E, 54K, 97A, 99D, 100E, 145K, 178P, 179G, 180V, 181G, 182K, 183K, 184F, 213K, 214S, 238Y, 239S, 240I, 241G, 242N, 243E, 244E, 245T, 270R, 293Y, 294T, 295K, 296S, 298K, 327R, 328L, 332Y, 335D
CDD
cd03586 (PolY_Pol_IV_kappa)

327R

DNA binding site
34E, 54K, 97A, 99D, 100E, 145K, 178P, 179G, 180V, 181G, 182K, 183K, 184F, 213K, 214S, 238Y, 239S, 240I, 241G, 242N, 243E, 244E, 245T, 270R, 293Y, 294T, 295K, 296S, 298K, 327R, 328L, 332Y, 335D
CDD
cd03586 (PolY_Pol_IV_kappa)

328L

DNA binding site
34E, 54K, 97A, 99D, 100E, 145K, 178P, 179G, 180V, 181G, 182K, 183K, 184F, 213K, 214S, 238Y, 239S, 240I, 241G, 242N, 243E, 244E, 245T, 270R, 293Y, 294T, 295K, 296S, 298K, 327R, 328L, 332Y, 335D
CDD
cd03586 (PolY_Pol_IV_kappa)

332Y

DNA binding site
34E, 54K, 97A, 99D, 100E, 145K, 178P, 179G, 180V, 181G, 182K, 183K, 184F, 213K, 214S, 238Y, 239S, 240I, 241G, 242N, 243E, 244E, 245T, 270R, 293Y, 294T, 295K, 296S, 298K, 327R, 328L, 332Y, 335D
CDD
cd03586 (PolY_Pol_IV_kappa)

335D

DNA binding site
34E, 54K, 97A, 99D, 100E, 145K, 178P, 179G, 180V, 181G, 182K, 183K, 184F, 213K, 214S, 238Y, 239S, 240I, 241G, 242N, 243E, 244E, 245T, 270R, 293Y, 294T, 295K, 296S, 298K, 327R, 328L, 332Y, 335D
CDD
cd03586 (PolY_Pol_IV_kappa)

GO term prediction

Biological Process

GO:0006281 DNA repair

Molecular Function

GO:0003684 damaged DNA binding
GO:0003887 DNA-directed DNA polymerase activity

Cellular Component

None predicted.

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Entry type

Status

Per-residue features

25586_FusoPortal_Gene_1734

Protein family membership

Homologous superfamilies

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component