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Protein

25586_FusoPortal_Gene_1755

Length

306 amino acids

Protein family membership

Cysteine synthase (IPR005856)
- Cysteine synthase CysK (IPR005859)

Homologous superfamilies

Homologous superfamily
2 - 303
Tryptophan synthase beta subunit-like PLP-dependent enzyme (IPR036052)

1 50 100 150 200 250 306

Domains and repeats

Domain
9 - 293
Pyridoxal-phosphate dependent enzyme (IPR001926)

1 50 100 150 200 250 306

Detailed signature matches

IPR036052

Tryptophan synthase beta subunit-like PLP-dependent enzyme

SSF53686 (Tryptopha...)

2 - 303

SUPERFAMILY
SSF53686 (Tryptophan synthase beta subunit-like PLP-dependent enzymes)

IPR005856

Cysteine synthase

TIGR01136

8 - 302

TIGRFAMs
TIGR01136 (TIGR01136)

IPR005859

Cysteine synthase CysK

TIGR01139

8 - 301

TIGRFAMs
TIGR01139 (TIGR01139)

IPR001926

Pyridoxal-phosphate dependent enzyme

PF00291 (PALP)

9 - 293

Pfam
PF00291 (PALP)

no IPR

Unintegrated signatures

G3DSA:3.40.50...

132 - 305

GENE3D
G3DSA:3.40.50.1100 (G3DSA:3.40.50.1100)

19 - 131

GENE3D
G3DSA:3.40.50.1100 (G3DSA:3.40.50.1100)
PTHR10314 (SER/THR ...)

2 - 302

PANTHER
PTHR10314 (SER/THR DEHYDRATASE, TRP SYNTHASE)
PTHR10314:SF133 (SU...)

2 - 302

PANTHER
PTHR10314:SF133 (SUBFAMILY NOT NAMED)
cd01561 (CBS_like)

11 - 301

CDD
cd01561 (CBS_like)

Residue annotation

dimer interface cd...

15L

dimer interface
15L, 16V, 17K, 29Y, 35S, 37P, 79M, 82A, 98I, 99E, 102Q, 103L, 106A, 107Y, 162K, 163D, 256S, 257F, 258K, 260G, 261I, 262L, 287K, 297E, 300L
CDD
cd01561 (CBS_like)

16V

dimer interface
15L, 16V, 17K, 29Y, 35S, 37P, 79M, 82A, 98I, 99E, 102Q, 103L, 106A, 107Y, 162K, 163D, 256S, 257F, 258K, 260G, 261I, 262L, 287K, 297E, 300L
CDD
cd01561 (CBS_like)

17K

dimer interface
15L, 16V, 17K, 29Y, 35S, 37P, 79M, 82A, 98I, 99E, 102Q, 103L, 106A, 107Y, 162K, 163D, 256S, 257F, 258K, 260G, 261I, 262L, 287K, 297E, 300L
CDD
cd01561 (CBS_like)

29Y

dimer interface
15L, 16V, 17K, 29Y, 35S, 37P, 79M, 82A, 98I, 99E, 102Q, 103L, 106A, 107Y, 162K, 163D, 256S, 257F, 258K, 260G, 261I, 262L, 287K, 297E, 300L
CDD
cd01561 (CBS_like)

35S

dimer interface
15L, 16V, 17K, 29Y, 35S, 37P, 79M, 82A, 98I, 99E, 102Q, 103L, 106A, 107Y, 162K, 163D, 256S, 257F, 258K, 260G, 261I, 262L, 287K, 297E, 300L
CDD
cd01561 (CBS_like)

37P

dimer interface
15L, 16V, 17K, 29Y, 35S, 37P, 79M, 82A, 98I, 99E, 102Q, 103L, 106A, 107Y, 162K, 163D, 256S, 257F, 258K, 260G, 261I, 262L, 287K, 297E, 300L
CDD
cd01561 (CBS_like)

79M

dimer interface
15L, 16V, 17K, 29Y, 35S, 37P, 79M, 82A, 98I, 99E, 102Q, 103L, 106A, 107Y, 162K, 163D, 256S, 257F, 258K, 260G, 261I, 262L, 287K, 297E, 300L
CDD
cd01561 (CBS_like)

82A

dimer interface
15L, 16V, 17K, 29Y, 35S, 37P, 79M, 82A, 98I, 99E, 102Q, 103L, 106A, 107Y, 162K, 163D, 256S, 257F, 258K, 260G, 261I, 262L, 287K, 297E, 300L
CDD
cd01561 (CBS_like)

98I

dimer interface
15L, 16V, 17K, 29Y, 35S, 37P, 79M, 82A, 98I, 99E, 102Q, 103L, 106A, 107Y, 162K, 163D, 256S, 257F, 258K, 260G, 261I, 262L, 287K, 297E, 300L
CDD
cd01561 (CBS_like)

99E

dimer interface
15L, 16V, 17K, 29Y, 35S, 37P, 79M, 82A, 98I, 99E, 102Q, 103L, 106A, 107Y, 162K, 163D, 256S, 257F, 258K, 260G, 261I, 262L, 287K, 297E, 300L
CDD
cd01561 (CBS_like)

102Q

dimer interface
15L, 16V, 17K, 29Y, 35S, 37P, 79M, 82A, 98I, 99E, 102Q, 103L, 106A, 107Y, 162K, 163D, 256S, 257F, 258K, 260G, 261I, 262L, 287K, 297E, 300L
CDD
cd01561 (CBS_like)

103L

dimer interface
15L, 16V, 17K, 29Y, 35S, 37P, 79M, 82A, 98I, 99E, 102Q, 103L, 106A, 107Y, 162K, 163D, 256S, 257F, 258K, 260G, 261I, 262L, 287K, 297E, 300L
CDD
cd01561 (CBS_like)

106A

dimer interface
15L, 16V, 17K, 29Y, 35S, 37P, 79M, 82A, 98I, 99E, 102Q, 103L, 106A, 107Y, 162K, 163D, 256S, 257F, 258K, 260G, 261I, 262L, 287K, 297E, 300L
CDD
cd01561 (CBS_like)

107Y

dimer interface
15L, 16V, 17K, 29Y, 35S, 37P, 79M, 82A, 98I, 99E, 102Q, 103L, 106A, 107Y, 162K, 163D, 256S, 257F, 258K, 260G, 261I, 262L, 287K, 297E, 300L
CDD
cd01561 (CBS_like)

162K

dimer interface
15L, 16V, 17K, 29Y, 35S, 37P, 79M, 82A, 98I, 99E, 102Q, 103L, 106A, 107Y, 162K, 163D, 256S, 257F, 258K, 260G, 261I, 262L, 287K, 297E, 300L
CDD
cd01561 (CBS_like)

163D

dimer interface
15L, 16V, 17K, 29Y, 35S, 37P, 79M, 82A, 98I, 99E, 102Q, 103L, 106A, 107Y, 162K, 163D, 256S, 257F, 258K, 260G, 261I, 262L, 287K, 297E, 300L
CDD
cd01561 (CBS_like)

256S

dimer interface
15L, 16V, 17K, 29Y, 35S, 37P, 79M, 82A, 98I, 99E, 102Q, 103L, 106A, 107Y, 162K, 163D, 256S, 257F, 258K, 260G, 261I, 262L, 287K, 297E, 300L
CDD
cd01561 (CBS_like)

257F

dimer interface
15L, 16V, 17K, 29Y, 35S, 37P, 79M, 82A, 98I, 99E, 102Q, 103L, 106A, 107Y, 162K, 163D, 256S, 257F, 258K, 260G, 261I, 262L, 287K, 297E, 300L
CDD
cd01561 (CBS_like)

258K

dimer interface
15L, 16V, 17K, 29Y, 35S, 37P, 79M, 82A, 98I, 99E, 102Q, 103L, 106A, 107Y, 162K, 163D, 256S, 257F, 258K, 260G, 261I, 262L, 287K, 297E, 300L
CDD
cd01561 (CBS_like)

260G

dimer interface
15L, 16V, 17K, 29Y, 35S, 37P, 79M, 82A, 98I, 99E, 102Q, 103L, 106A, 107Y, 162K, 163D, 256S, 257F, 258K, 260G, 261I, 262L, 287K, 297E, 300L
CDD
cd01561 (CBS_like)

261I

dimer interface
15L, 16V, 17K, 29Y, 35S, 37P, 79M, 82A, 98I, 99E, 102Q, 103L, 106A, 107Y, 162K, 163D, 256S, 257F, 258K, 260G, 261I, 262L, 287K, 297E, 300L
CDD
cd01561 (CBS_like)

262L

dimer interface
15L, 16V, 17K, 29Y, 35S, 37P, 79M, 82A, 98I, 99E, 102Q, 103L, 106A, 107Y, 162K, 163D, 256S, 257F, 258K, 260G, 261I, 262L, 287K, 297E, 300L
CDD
cd01561 (CBS_like)

287K

dimer interface
15L, 16V, 17K, 29Y, 35S, 37P, 79M, 82A, 98I, 99E, 102Q, 103L, 106A, 107Y, 162K, 163D, 256S, 257F, 258K, 260G, 261I, 262L, 287K, 297E, 300L
CDD
cd01561 (CBS_like)

297E

dimer interface
15L, 16V, 17K, 29Y, 35S, 37P, 79M, 82A, 98I, 99E, 102Q, 103L, 106A, 107Y, 162K, 163D, 256S, 257F, 258K, 260G, 261I, 262L, 287K, 297E, 300L
CDD
cd01561 (CBS_like)

300L

dimer interface
15L, 16V, 17K, 29Y, 35S, 37P, 79M, 82A, 98I, 99E, 102Q, 103L, 106A, 107Y, 162K, 163D, 256S, 257F, 258K, 260G, 261I, 262L, 287K, 297E, 300L
CDD
cd01561 (CBS_like)
catalytic residue ...

42K

catalytic residue
42K
CDD
cd01561 (CBS_like)
pyridoxal 5'-phosp...

42K

pyridoxal 5'-phosphate binding site
42K, 72N, 175T, 176G, 177T, 178G, 179G, 180S, 220G, 266S, 293T, 294D
CDD
cd01561 (CBS_like)

72N

pyridoxal 5'-phosphate binding site
42K, 72N, 175T, 176G, 177T, 178G, 179G, 180S, 220G, 266S, 293T, 294D
CDD
cd01561 (CBS_like)

175T

pyridoxal 5'-phosphate binding site
42K, 72N, 175T, 176G, 177T, 178G, 179G, 180S, 220G, 266S, 293T, 294D
CDD
cd01561 (CBS_like)

176G

pyridoxal 5'-phosphate binding site
42K, 72N, 175T, 176G, 177T, 178G, 179G, 180S, 220G, 266S, 293T, 294D
CDD
cd01561 (CBS_like)

177T

pyridoxal 5'-phosphate binding site
42K, 72N, 175T, 176G, 177T, 178G, 179G, 180S, 220G, 266S, 293T, 294D
CDD
cd01561 (CBS_like)

178G

pyridoxal 5'-phosphate binding site
42K, 72N, 175T, 176G, 177T, 178G, 179G, 180S, 220G, 266S, 293T, 294D
CDD
cd01561 (CBS_like)

179G

pyridoxal 5'-phosphate binding site
42K, 72N, 175T, 176G, 177T, 178G, 179G, 180S, 220G, 266S, 293T, 294D
CDD
cd01561 (CBS_like)

180S

pyridoxal 5'-phosphate binding site
42K, 72N, 175T, 176G, 177T, 178G, 179G, 180S, 220G, 266S, 293T, 294D
CDD
cd01561 (CBS_like)

220G

pyridoxal 5'-phosphate binding site
42K, 72N, 175T, 176G, 177T, 178G, 179G, 180S, 220G, 266S, 293T, 294D
CDD
cd01561 (CBS_like)

266S

pyridoxal 5'-phosphate binding site
42K, 72N, 175T, 176G, 177T, 178G, 179G, 180S, 220G, 266S, 293T, 294D
CDD
cd01561 (CBS_like)

293T

pyridoxal 5'-phosphate binding site
42K, 72N, 175T, 176G, 177T, 178G, 179G, 180S, 220G, 266S, 293T, 294D
CDD
cd01561 (CBS_like)

294D

pyridoxal 5'-phosphate binding site
42K, 72N, 175T, 176G, 177T, 178G, 179G, 180S, 220G, 266S, 293T, 294D
CDD
cd01561 (CBS_like)

GO term prediction

Biological Process

GO:0006535 cysteine biosynthetic process from serine

Molecular Function

GO:0004124 cysteine synthase activity

Cellular Component

None predicted.