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Protein

25586_FusoPortal_Gene_176

Length

336 amino acids

Protein family membership

UDP-N-acetylglucosamine 4,6-dehydratase (inverting) (IPR020025)

Homologous superfamilies

Homologous superfamily
1 - 264
NAD(P)-binding domain superfamily (IPR036291)

1 50 100 150 200 250 300 336

Domains and repeats

Domain
4 - 286
Polysaccharide biosynthesis protein, CapD-like domain (IPR003869)

1 50 100 150 200 250 300 336

Detailed signature matches

IPR036291

NAD(P)-binding domain superfamily

SSF51735 (NAD(P)-bi...)

1 - 264

SUPERFAMILY
SSF51735 (NAD(P)-binding Rossmann-fold domains)

IPR020025

UDP-N-acetylglucosamine 4,6-dehydratase (inverting)

TIGR03589

1 - 327

TIGRFAMs
TIGR03589 (TIGR03589)

IPR003869

Polysaccharide biosynthesis protein, CapD-like domain

cd05237 (UDP_invert...)

4 - 285

CDD
cd05237 (UDP_invert_4-6DH_SDR_e)
PF02719 (Polysacc_s...)

7 - 286

Pfam
PF02719 (Polysacc_synt_2)

no IPR

Unintegrated signatures

G3DSA:3.40.50...

1 - 335

GENE3D
G3DSA:3.40.50.720 (G3DSA:3.40.50.720)
PTHR43318 (FAMILY N...)

1 - 331

PANTHER
PTHR43318 (FAMILY NOT NAMED)
PTHR43318:SF2 (SUBF...)

1 - 331

PANTHER
PTHR43318:SF2 (SUBFAMILY NOT NAMED)

Residue annotation

NAD(P) binding sit...

11G

NAD(P) binding site
11G, 13T, 14G, 15S, 16F, 37S, 38R, 67G, 68D, 69V, 88A, 89A, 90A, 92K, 107T, 130L, 146K, 172Y, 173G, 174N, 175V, 178S, 179R
CDD
cd05237 (UDP_invert_4-6DH_SDR_e)

13T

NAD(P) binding site
11G, 13T, 14G, 15S, 16F, 37S, 38R, 67G, 68D, 69V, 88A, 89A, 90A, 92K, 107T, 130L, 146K, 172Y, 173G, 174N, 175V, 178S, 179R
CDD
cd05237 (UDP_invert_4-6DH_SDR_e)

14G

NAD(P) binding site
11G, 13T, 14G, 15S, 16F, 37S, 38R, 67G, 68D, 69V, 88A, 89A, 90A, 92K, 107T, 130L, 146K, 172Y, 173G, 174N, 175V, 178S, 179R
CDD
cd05237 (UDP_invert_4-6DH_SDR_e)

15S

NAD(P) binding site
11G, 13T, 14G, 15S, 16F, 37S, 38R, 67G, 68D, 69V, 88A, 89A, 90A, 92K, 107T, 130L, 146K, 172Y, 173G, 174N, 175V, 178S, 179R
CDD
cd05237 (UDP_invert_4-6DH_SDR_e)

16F

NAD(P) binding site
11G, 13T, 14G, 15S, 16F, 37S, 38R, 67G, 68D, 69V, 88A, 89A, 90A, 92K, 107T, 130L, 146K, 172Y, 173G, 174N, 175V, 178S, 179R
CDD
cd05237 (UDP_invert_4-6DH_SDR_e)

37S

NAD(P) binding site
11G, 13T, 14G, 15S, 16F, 37S, 38R, 67G, 68D, 69V, 88A, 89A, 90A, 92K, 107T, 130L, 146K, 172Y, 173G, 174N, 175V, 178S, 179R
CDD
cd05237 (UDP_invert_4-6DH_SDR_e)

38R

NAD(P) binding site
11G, 13T, 14G, 15S, 16F, 37S, 38R, 67G, 68D, 69V, 88A, 89A, 90A, 92K, 107T, 130L, 146K, 172Y, 173G, 174N, 175V, 178S, 179R
CDD
cd05237 (UDP_invert_4-6DH_SDR_e)

67G

NAD(P) binding site
11G, 13T, 14G, 15S, 16F, 37S, 38R, 67G, 68D, 69V, 88A, 89A, 90A, 92K, 107T, 130L, 146K, 172Y, 173G, 174N, 175V, 178S, 179R
CDD
cd05237 (UDP_invert_4-6DH_SDR_e)

68D

NAD(P) binding site
11G, 13T, 14G, 15S, 16F, 37S, 38R, 67G, 68D, 69V, 88A, 89A, 90A, 92K, 107T, 130L, 146K, 172Y, 173G, 174N, 175V, 178S, 179R
CDD
cd05237 (UDP_invert_4-6DH_SDR_e)

69V

NAD(P) binding site
11G, 13T, 14G, 15S, 16F, 37S, 38R, 67G, 68D, 69V, 88A, 89A, 90A, 92K, 107T, 130L, 146K, 172Y, 173G, 174N, 175V, 178S, 179R
CDD
cd05237 (UDP_invert_4-6DH_SDR_e)

88A

NAD(P) binding site
11G, 13T, 14G, 15S, 16F, 37S, 38R, 67G, 68D, 69V, 88A, 89A, 90A, 92K, 107T, 130L, 146K, 172Y, 173G, 174N, 175V, 178S, 179R
CDD
cd05237 (UDP_invert_4-6DH_SDR_e)

89A

NAD(P) binding site
11G, 13T, 14G, 15S, 16F, 37S, 38R, 67G, 68D, 69V, 88A, 89A, 90A, 92K, 107T, 130L, 146K, 172Y, 173G, 174N, 175V, 178S, 179R
CDD
cd05237 (UDP_invert_4-6DH_SDR_e)

90A

NAD(P) binding site
11G, 13T, 14G, 15S, 16F, 37S, 38R, 67G, 68D, 69V, 88A, 89A, 90A, 92K, 107T, 130L, 146K, 172Y, 173G, 174N, 175V, 178S, 179R
CDD
cd05237 (UDP_invert_4-6DH_SDR_e)

92K

NAD(P) binding site
11G, 13T, 14G, 15S, 16F, 37S, 38R, 67G, 68D, 69V, 88A, 89A, 90A, 92K, 107T, 130L, 146K, 172Y, 173G, 174N, 175V, 178S, 179R
CDD
cd05237 (UDP_invert_4-6DH_SDR_e)

107T

NAD(P) binding site
11G, 13T, 14G, 15S, 16F, 37S, 38R, 67G, 68D, 69V, 88A, 89A, 90A, 92K, 107T, 130L, 146K, 172Y, 173G, 174N, 175V, 178S, 179R
CDD
cd05237 (UDP_invert_4-6DH_SDR_e)

130L

NAD(P) binding site
11G, 13T, 14G, 15S, 16F, 37S, 38R, 67G, 68D, 69V, 88A, 89A, 90A, 92K, 107T, 130L, 146K, 172Y, 173G, 174N, 175V, 178S, 179R
CDD
cd05237 (UDP_invert_4-6DH_SDR_e)

146K

NAD(P) binding site
11G, 13T, 14G, 15S, 16F, 37S, 38R, 67G, 68D, 69V, 88A, 89A, 90A, 92K, 107T, 130L, 146K, 172Y, 173G, 174N, 175V, 178S, 179R
CDD
cd05237 (UDP_invert_4-6DH_SDR_e)

172Y

NAD(P) binding site
11G, 13T, 14G, 15S, 16F, 37S, 38R, 67G, 68D, 69V, 88A, 89A, 90A, 92K, 107T, 130L, 146K, 172Y, 173G, 174N, 175V, 178S, 179R
CDD
cd05237 (UDP_invert_4-6DH_SDR_e)

173G

NAD(P) binding site
11G, 13T, 14G, 15S, 16F, 37S, 38R, 67G, 68D, 69V, 88A, 89A, 90A, 92K, 107T, 130L, 146K, 172Y, 173G, 174N, 175V, 178S, 179R
CDD
cd05237 (UDP_invert_4-6DH_SDR_e)

174N

NAD(P) binding site
11G, 13T, 14G, 15S, 16F, 37S, 38R, 67G, 68D, 69V, 88A, 89A, 90A, 92K, 107T, 130L, 146K, 172Y, 173G, 174N, 175V, 178S, 179R
CDD
cd05237 (UDP_invert_4-6DH_SDR_e)

175V

NAD(P) binding site
11G, 13T, 14G, 15S, 16F, 37S, 38R, 67G, 68D, 69V, 88A, 89A, 90A, 92K, 107T, 130L, 146K, 172Y, 173G, 174N, 175V, 178S, 179R
CDD
cd05237 (UDP_invert_4-6DH_SDR_e)

178S

NAD(P) binding site
11G, 13T, 14G, 15S, 16F, 37S, 38R, 67G, 68D, 69V, 88A, 89A, 90A, 92K, 107T, 130L, 146K, 172Y, 173G, 174N, 175V, 178S, 179R
CDD
cd05237 (UDP_invert_4-6DH_SDR_e)

179R

NAD(P) binding site
11G, 13T, 14G, 15S, 16F, 37S, 38R, 67G, 68D, 69V, 88A, 89A, 90A, 92K, 107T, 130L, 146K, 172Y, 173G, 174N, 175V, 178S, 179R
CDD
cd05237 (UDP_invert_4-6DH_SDR_e)
homodimer interfac...

38R

homodimer interface
38R, 40E, 44D, 48K, 65F, 66I, 67G, 68D, 71D, 74R, 90A, 91M, 92K, 93Q, 96A, 100N, 103E, 106K, 179R, 180G, 185F
CDD
cd05237 (UDP_invert_4-6DH_SDR_e)

40E

homodimer interface
38R, 40E, 44D, 48K, 65F, 66I, 67G, 68D, 71D, 74R, 90A, 91M, 92K, 93Q, 96A, 100N, 103E, 106K, 179R, 180G, 185F
CDD
cd05237 (UDP_invert_4-6DH_SDR_e)

44D

homodimer interface
38R, 40E, 44D, 48K, 65F, 66I, 67G, 68D, 71D, 74R, 90A, 91M, 92K, 93Q, 96A, 100N, 103E, 106K, 179R, 180G, 185F
CDD
cd05237 (UDP_invert_4-6DH_SDR_e)

48K

homodimer interface
38R, 40E, 44D, 48K, 65F, 66I, 67G, 68D, 71D, 74R, 90A, 91M, 92K, 93Q, 96A, 100N, 103E, 106K, 179R, 180G, 185F
CDD
cd05237 (UDP_invert_4-6DH_SDR_e)

65F

homodimer interface
38R, 40E, 44D, 48K, 65F, 66I, 67G, 68D, 71D, 74R, 90A, 91M, 92K, 93Q, 96A, 100N, 103E, 106K, 179R, 180G, 185F
CDD
cd05237 (UDP_invert_4-6DH_SDR_e)

66I

homodimer interface
38R, 40E, 44D, 48K, 65F, 66I, 67G, 68D, 71D, 74R, 90A, 91M, 92K, 93Q, 96A, 100N, 103E, 106K, 179R, 180G, 185F
CDD
cd05237 (UDP_invert_4-6DH_SDR_e)

67G

homodimer interface
38R, 40E, 44D, 48K, 65F, 66I, 67G, 68D, 71D, 74R, 90A, 91M, 92K, 93Q, 96A, 100N, 103E, 106K, 179R, 180G, 185F
CDD
cd05237 (UDP_invert_4-6DH_SDR_e)

68D

homodimer interface
38R, 40E, 44D, 48K, 65F, 66I, 67G, 68D, 71D, 74R, 90A, 91M, 92K, 93Q, 96A, 100N, 103E, 106K, 179R, 180G, 185F
CDD
cd05237 (UDP_invert_4-6DH_SDR_e)

71D

homodimer interface
38R, 40E, 44D, 48K, 65F, 66I, 67G, 68D, 71D, 74R, 90A, 91M, 92K, 93Q, 96A, 100N, 103E, 106K, 179R, 180G, 185F
CDD
cd05237 (UDP_invert_4-6DH_SDR_e)

74R

homodimer interface
38R, 40E, 44D, 48K, 65F, 66I, 67G, 68D, 71D, 74R, 90A, 91M, 92K, 93Q, 96A, 100N, 103E, 106K, 179R, 180G, 185F
CDD
cd05237 (UDP_invert_4-6DH_SDR_e)

90A

homodimer interface
38R, 40E, 44D, 48K, 65F, 66I, 67G, 68D, 71D, 74R, 90A, 91M, 92K, 93Q, 96A, 100N, 103E, 106K, 179R, 180G, 185F
CDD
cd05237 (UDP_invert_4-6DH_SDR_e)

91M

homodimer interface
38R, 40E, 44D, 48K, 65F, 66I, 67G, 68D, 71D, 74R, 90A, 91M, 92K, 93Q, 96A, 100N, 103E, 106K, 179R, 180G, 185F
CDD
cd05237 (UDP_invert_4-6DH_SDR_e)

92K

homodimer interface
38R, 40E, 44D, 48K, 65F, 66I, 67G, 68D, 71D, 74R, 90A, 91M, 92K, 93Q, 96A, 100N, 103E, 106K, 179R, 180G, 185F
CDD
cd05237 (UDP_invert_4-6DH_SDR_e)

93Q

homodimer interface
38R, 40E, 44D, 48K, 65F, 66I, 67G, 68D, 71D, 74R, 90A, 91M, 92K, 93Q, 96A, 100N, 103E, 106K, 179R, 180G, 185F
CDD
cd05237 (UDP_invert_4-6DH_SDR_e)

96A

homodimer interface
38R, 40E, 44D, 48K, 65F, 66I, 67G, 68D, 71D, 74R, 90A, 91M, 92K, 93Q, 96A, 100N, 103E, 106K, 179R, 180G, 185F
CDD
cd05237 (UDP_invert_4-6DH_SDR_e)

100N

homodimer interface
38R, 40E, 44D, 48K, 65F, 66I, 67G, 68D, 71D, 74R, 90A, 91M, 92K, 93Q, 96A, 100N, 103E, 106K, 179R, 180G, 185F
CDD
cd05237 (UDP_invert_4-6DH_SDR_e)

103E

homodimer interface
38R, 40E, 44D, 48K, 65F, 66I, 67G, 68D, 71D, 74R, 90A, 91M, 92K, 93Q, 96A, 100N, 103E, 106K, 179R, 180G, 185F
CDD
cd05237 (UDP_invert_4-6DH_SDR_e)

106K

homodimer interface
38R, 40E, 44D, 48K, 65F, 66I, 67G, 68D, 71D, 74R, 90A, 91M, 92K, 93Q, 96A, 100N, 103E, 106K, 179R, 180G, 185F
CDD
cd05237 (UDP_invert_4-6DH_SDR_e)

179R

homodimer interface
38R, 40E, 44D, 48K, 65F, 66I, 67G, 68D, 71D, 74R, 90A, 91M, 92K, 93Q, 96A, 100N, 103E, 106K, 179R, 180G, 185F
CDD
cd05237 (UDP_invert_4-6DH_SDR_e)

180G

homodimer interface
38R, 40E, 44D, 48K, 65F, 66I, 67G, 68D, 71D, 74R, 90A, 91M, 92K, 93Q, 96A, 100N, 103E, 106K, 179R, 180G, 185F
CDD
cd05237 (UDP_invert_4-6DH_SDR_e)

185F

homodimer interface
38R, 40E, 44D, 48K, 65F, 66I, 67G, 68D, 71D, 74R, 90A, 91M, 92K, 93Q, 96A, 100N, 103E, 106K, 179R, 180G, 185F
CDD
cd05237 (UDP_invert_4-6DH_SDR_e)
substrate binding ...

92K

substrate binding site
92K, 132T, 133D, 134K, 142Y, 173G, 174N, 180G, 181S, 182V, 185F, 186F, 198P, 199I, 200T, 204M, 206R, 240I, 259R, 262E
CDD
cd05237 (UDP_invert_4-6DH_SDR_e)

132T

substrate binding site
92K, 132T, 133D, 134K, 142Y, 173G, 174N, 180G, 181S, 182V, 185F, 186F, 198P, 199I, 200T, 204M, 206R, 240I, 259R, 262E
CDD
cd05237 (UDP_invert_4-6DH_SDR_e)

133D

substrate binding site
92K, 132T, 133D, 134K, 142Y, 173G, 174N, 180G, 181S, 182V, 185F, 186F, 198P, 199I, 200T, 204M, 206R, 240I, 259R, 262E
CDD
cd05237 (UDP_invert_4-6DH_SDR_e)

134K

substrate binding site
92K, 132T, 133D, 134K, 142Y, 173G, 174N, 180G, 181S, 182V, 185F, 186F, 198P, 199I, 200T, 204M, 206R, 240I, 259R, 262E
CDD
cd05237 (UDP_invert_4-6DH_SDR_e)

142Y

substrate binding site
92K, 132T, 133D, 134K, 142Y, 173G, 174N, 180G, 181S, 182V, 185F, 186F, 198P, 199I, 200T, 204M, 206R, 240I, 259R, 262E
CDD
cd05237 (UDP_invert_4-6DH_SDR_e)

173G

substrate binding site
92K, 132T, 133D, 134K, 142Y, 173G, 174N, 180G, 181S, 182V, 185F, 186F, 198P, 199I, 200T, 204M, 206R, 240I, 259R, 262E
CDD
cd05237 (UDP_invert_4-6DH_SDR_e)

174N

substrate binding site
92K, 132T, 133D, 134K, 142Y, 173G, 174N, 180G, 181S, 182V, 185F, 186F, 198P, 199I, 200T, 204M, 206R, 240I, 259R, 262E
CDD
cd05237 (UDP_invert_4-6DH_SDR_e)

180G

substrate binding site
92K, 132T, 133D, 134K, 142Y, 173G, 174N, 180G, 181S, 182V, 185F, 186F, 198P, 199I, 200T, 204M, 206R, 240I, 259R, 262E
CDD
cd05237 (UDP_invert_4-6DH_SDR_e)

181S

substrate binding site
92K, 132T, 133D, 134K, 142Y, 173G, 174N, 180G, 181S, 182V, 185F, 186F, 198P, 199I, 200T, 204M, 206R, 240I, 259R, 262E
CDD
cd05237 (UDP_invert_4-6DH_SDR_e)

182V

substrate binding site
92K, 132T, 133D, 134K, 142Y, 173G, 174N, 180G, 181S, 182V, 185F, 186F, 198P, 199I, 200T, 204M, 206R, 240I, 259R, 262E
CDD
cd05237 (UDP_invert_4-6DH_SDR_e)

185F

substrate binding site
92K, 132T, 133D, 134K, 142Y, 173G, 174N, 180G, 181S, 182V, 185F, 186F, 198P, 199I, 200T, 204M, 206R, 240I, 259R, 262E
CDD
cd05237 (UDP_invert_4-6DH_SDR_e)

186F

substrate binding site
92K, 132T, 133D, 134K, 142Y, 173G, 174N, 180G, 181S, 182V, 185F, 186F, 198P, 199I, 200T, 204M, 206R, 240I, 259R, 262E
CDD
cd05237 (UDP_invert_4-6DH_SDR_e)

198P

substrate binding site
92K, 132T, 133D, 134K, 142Y, 173G, 174N, 180G, 181S, 182V, 185F, 186F, 198P, 199I, 200T, 204M, 206R, 240I, 259R, 262E
CDD
cd05237 (UDP_invert_4-6DH_SDR_e)

199I

substrate binding site
92K, 132T, 133D, 134K, 142Y, 173G, 174N, 180G, 181S, 182V, 185F, 186F, 198P, 199I, 200T, 204M, 206R, 240I, 259R, 262E
CDD
cd05237 (UDP_invert_4-6DH_SDR_e)

200T

substrate binding site
92K, 132T, 133D, 134K, 142Y, 173G, 174N, 180G, 181S, 182V, 185F, 186F, 198P, 199I, 200T, 204M, 206R, 240I, 259R, 262E
CDD
cd05237 (UDP_invert_4-6DH_SDR_e)

204M

substrate binding site
92K, 132T, 133D, 134K, 142Y, 173G, 174N, 180G, 181S, 182V, 185F, 186F, 198P, 199I, 200T, 204M, 206R, 240I, 259R, 262E
CDD
cd05237 (UDP_invert_4-6DH_SDR_e)

206R

substrate binding site
92K, 132T, 133D, 134K, 142Y, 173G, 174N, 180G, 181S, 182V, 185F, 186F, 198P, 199I, 200T, 204M, 206R, 240I, 259R, 262E
CDD
cd05237 (UDP_invert_4-6DH_SDR_e)

240I

substrate binding site
92K, 132T, 133D, 134K, 142Y, 173G, 174N, 180G, 181S, 182V, 185F, 186F, 198P, 199I, 200T, 204M, 206R, 240I, 259R, 262E
CDD
cd05237 (UDP_invert_4-6DH_SDR_e)

259R

substrate binding site
92K, 132T, 133D, 134K, 142Y, 173G, 174N, 180G, 181S, 182V, 185F, 186F, 198P, 199I, 200T, 204M, 206R, 240I, 259R, 262E
CDD
cd05237 (UDP_invert_4-6DH_SDR_e)

262E

substrate binding site
92K, 132T, 133D, 134K, 142Y, 173G, 174N, 180G, 181S, 182V, 185F, 186F, 198P, 199I, 200T, 204M, 206R, 240I, 259R, 262E
CDD
cd05237 (UDP_invert_4-6DH_SDR_e)
active site cd05237

108N

active site
108N, 132T, 142Y, 146K
CDD
cd05237 (UDP_invert_4-6DH_SDR_e)

132T

active site
108N, 132T, 142Y, 146K
CDD
cd05237 (UDP_invert_4-6DH_SDR_e)

142Y

active site
108N, 132T, 142Y, 146K
CDD
cd05237 (UDP_invert_4-6DH_SDR_e)

146K

active site
108N, 132T, 142Y, 146K
CDD
cd05237 (UDP_invert_4-6DH_SDR_e)

GO term prediction

Biological Process

None predicted.

Molecular Function

None predicted.

Cellular Component

None predicted.

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Entry type

Status

Per-residue features

25586_FusoPortal_Gene_176

Protein family membership

Homologous superfamilies

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component