25586_FusoPortal_Gene_1935

Protein

25586_FusoPortal_Gene_1935

Length

511 amino acids

Protein family membership

Aromatic amino acid lyase (IPR001106)
- Histidine ammonia-lyase (IPR005921)

Homologous superfamilies

Homologous superfamily
2 - 501
L-Aspartase-like (IPR008948)
Homologous superfamily
3 - 198
Fumarase/histidase, N-terminal (IPR024083)

1 50 100 150 200 250 300 350 400 450 511

Domains and repeats

None predicted.

Detailed signature matches

IPR008948

L-Aspartase-like
1. SSF48557 (L-asparta...)
  
  2 - 501
  
  SUPERFAMILY
  SSF48557 (L-aspartase-like)
IPR024083

Fumarase/histidase, N-terminal
1. G3DSA:1.10.27...
  
  3 - 198
  
  GENE3D
  G3DSA:1.10.275.10 (G3DSA:1.10.275.10)
IPR001106

Aromatic amino acid lyase
1. PF00221 (Lyase_arom...)
  
  12 - 472
  
  Pfam
  PF00221 (Lyase_aromatic)
2. cd00332 (PAL-HAL)
  
  10 - 453
  
  CDD
  cd00332 (PAL-HAL)
IPR005921

Histidine ammonia-lyase
1. TIGR01225
  
  5 - 504
  
  TIGRFAMs
  TIGR01225 (TIGR01225)
2. MF_00229 (His_ammon...)
  
  4 - 505
  
  HAMAP
  MF_00229 (His_ammonia_lyase)
IPR022313

Phenylalanine/histidine ammonia-lyases, active site
1. PS00488 (PAL_HISTIDASE)
  
  140 - 156
  
  PROSITE patterns
  PS00488 (PAL_HISTIDASE)

no IPR

Unintegrated signatures

G3DSA:1.20.20...

200 - 509

GENE3D
G3DSA:1.20.200.10 (G3DSA:1.20.200.10)
PTHR10362 (HISTIDIN...)

3 - 506

PANTHER
PTHR10362 (HISTIDINE AMMONIA-LYASE)
PTHR10362:SF7 (HIST...)

3 - 506

PANTHER
PTHR10362:SF7 (HISTIDINE AMMONIA-LYASE)

Residue annotation

active sites cd00332

55Y

active sites
55Y, 56G, 57I, 59T, 61F, 78Q, 81L, 189A, 190K, 191E, 192G, 193L, 197N, 280Y, 283R, 313N, 326S
CDD
cd00332 (PAL-HAL)

56G

active sites
55Y, 56G, 57I, 59T, 61F, 78Q, 81L, 189A, 190K, 191E, 192G, 193L, 197N, 280Y, 283R, 313N, 326S
CDD
cd00332 (PAL-HAL)

57I

active sites
55Y, 56G, 57I, 59T, 61F, 78Q, 81L, 189A, 190K, 191E, 192G, 193L, 197N, 280Y, 283R, 313N, 326S
CDD
cd00332 (PAL-HAL)

59T

active sites
55Y, 56G, 57I, 59T, 61F, 78Q, 81L, 189A, 190K, 191E, 192G, 193L, 197N, 280Y, 283R, 313N, 326S
CDD
cd00332 (PAL-HAL)

61F

active sites
55Y, 56G, 57I, 59T, 61F, 78Q, 81L, 189A, 190K, 191E, 192G, 193L, 197N, 280Y, 283R, 313N, 326S
CDD
cd00332 (PAL-HAL)

78Q

active sites
55Y, 56G, 57I, 59T, 61F, 78Q, 81L, 189A, 190K, 191E, 192G, 193L, 197N, 280Y, 283R, 313N, 326S
CDD
cd00332 (PAL-HAL)

81L

active sites
55Y, 56G, 57I, 59T, 61F, 78Q, 81L, 189A, 190K, 191E, 192G, 193L, 197N, 280Y, 283R, 313N, 326S
CDD
cd00332 (PAL-HAL)

189A

active sites
55Y, 56G, 57I, 59T, 61F, 78Q, 81L, 189A, 190K, 191E, 192G, 193L, 197N, 280Y, 283R, 313N, 326S
CDD
cd00332 (PAL-HAL)

190K

active sites
55Y, 56G, 57I, 59T, 61F, 78Q, 81L, 189A, 190K, 191E, 192G, 193L, 197N, 280Y, 283R, 313N, 326S
CDD
cd00332 (PAL-HAL)

191E

active sites
55Y, 56G, 57I, 59T, 61F, 78Q, 81L, 189A, 190K, 191E, 192G, 193L, 197N, 280Y, 283R, 313N, 326S
CDD
cd00332 (PAL-HAL)

192G

active sites
55Y, 56G, 57I, 59T, 61F, 78Q, 81L, 189A, 190K, 191E, 192G, 193L, 197N, 280Y, 283R, 313N, 326S
CDD
cd00332 (PAL-HAL)

193L

active sites
55Y, 56G, 57I, 59T, 61F, 78Q, 81L, 189A, 190K, 191E, 192G, 193L, 197N, 280Y, 283R, 313N, 326S
CDD
cd00332 (PAL-HAL)

197N

active sites
55Y, 56G, 57I, 59T, 61F, 78Q, 81L, 189A, 190K, 191E, 192G, 193L, 197N, 280Y, 283R, 313N, 326S
CDD
cd00332 (PAL-HAL)

280Y

active sites
55Y, 56G, 57I, 59T, 61F, 78Q, 81L, 189A, 190K, 191E, 192G, 193L, 197N, 280Y, 283R, 313N, 326S
CDD
cd00332 (PAL-HAL)

283R

active sites
55Y, 56G, 57I, 59T, 61F, 78Q, 81L, 189A, 190K, 191E, 192G, 193L, 197N, 280Y, 283R, 313N, 326S
CDD
cd00332 (PAL-HAL)

313N

active sites
55Y, 56G, 57I, 59T, 61F, 78Q, 81L, 189A, 190K, 191E, 192G, 193L, 197N, 280Y, 283R, 313N, 326S
CDD
cd00332 (PAL-HAL)

326S

active sites
55Y, 56G, 57I, 59T, 61F, 78Q, 81L, 189A, 190K, 191E, 192G, 193L, 197N, 280Y, 283R, 313N, 326S
CDD
cd00332 (PAL-HAL)
tetramer interface...

60G

tetramer interface
60G, 61F, 80N, 83Y, 84S, 85D, 86A, 87C, 88G, 89V, 90G, 111K, 139K, 140G, 153H, 156L, 241R, 242I, 245I, 246R, 248H, 251Q, 277Q, 279A, 280Y, 281S, 283R, 284C, 287Q, 288V, 294L, 295A, 298Y, 301Q, 302T, 305T, 306E, 309S, 310V, 315L, 316I, 317F, 323A, 325I, 326S, 327G, 328G, 329N, 330F, 331H, 333Q, 334P, 337I, 341T, 348E, 351N, 355R, 359K, 362N, 365L, 378G, 379I, 381D, 382G, 384M, 385I, 386P, 387Q, 389V, 391A, 392A, 393L, 394V, 395S, 396E, 398K, 399V, 400L, 401A, 412S, 413A, 414N, 415Q, 416E, 417D, 418H, 421M, 427R, 428K, 431T, 434D, 435H
CDD
cd00332 (PAL-HAL)

61F

tetramer interface
60G, 61F, 80N, 83Y, 84S, 85D, 86A, 87C, 88G, 89V, 90G, 111K, 139K, 140G, 153H, 156L, 241R, 242I, 245I, 246R, 248H, 251Q, 277Q, 279A, 280Y, 281S, 283R, 284C, 287Q, 288V, 294L, 295A, 298Y, 301Q, 302T, 305T, 306E, 309S, 310V, 315L, 316I, 317F, 323A, 325I, 326S, 327G, 328G, 329N, 330F, 331H, 333Q, 334P, 337I, 341T, 348E, 351N, 355R, 359K, 362N, 365L, 378G, 379I, 381D, 382G, 384M, 385I, 386P, 387Q, 389V, 391A, 392A, 393L, 394V, 395S, 396E, 398K, 399V, 400L, 401A, 412S, 413A, 414N, 415Q, 416E, 417D, 418H, 421M, 427R, 428K, 431T, 434D, 435H
CDD
cd00332 (PAL-HAL)

80N

tetramer interface
60G, 61F, 80N, 83Y, 84S, 85D, 86A, 87C, 88G, 89V, 90G, 111K, 139K, 140G, 153H, 156L, 241R, 242I, 245I, 246R, 248H, 251Q, 277Q, 279A, 280Y, 281S, 283R, 284C, 287Q, 288V, 294L, 295A, 298Y, 301Q, 302T, 305T, 306E, 309S, 310V, 315L, 316I, 317F, 323A, 325I, 326S, 327G, 328G, 329N, 330F, 331H, 333Q, 334P, 337I, 341T, 348E, 351N, 355R, 359K, 362N, 365L, 378G, 379I, 381D, 382G, 384M, 385I, 386P, 387Q, 389V, 391A, 392A, 393L, 394V, 395S, 396E, 398K, 399V, 400L, 401A, 412S, 413A, 414N, 415Q, 416E, 417D, 418H, 421M, 427R, 428K, 431T, 434D, 435H
CDD
cd00332 (PAL-HAL)

83Y

tetramer interface
60G, 61F, 80N, 83Y, 84S, 85D, 86A, 87C, 88G, 89V, 90G, 111K, 139K, 140G, 153H, 156L, 241R, 242I, 245I, 246R, 248H, 251Q, 277Q, 279A, 280Y, 281S, 283R, 284C, 287Q, 288V, 294L, 295A, 298Y, 301Q, 302T, 305T, 306E, 309S, 310V, 315L, 316I, 317F, 323A, 325I, 326S, 327G, 328G, 329N, 330F, 331H, 333Q, 334P, 337I, 341T, 348E, 351N, 355R, 359K, 362N, 365L, 378G, 379I, 381D, 382G, 384M, 385I, 386P, 387Q, 389V, 391A, 392A, 393L, 394V, 395S, 396E, 398K, 399V, 400L, 401A, 412S, 413A, 414N, 415Q, 416E, 417D, 418H, 421M, 427R, 428K, 431T, 434D, 435H
CDD
cd00332 (PAL-HAL)

84S

tetramer interface
60G, 61F, 80N, 83Y, 84S, 85D, 86A, 87C, 88G, 89V, 90G, 111K, 139K, 140G, 153H, 156L, 241R, 242I, 245I, 246R, 248H, 251Q, 277Q, 279A, 280Y, 281S, 283R, 284C, 287Q, 288V, 294L, 295A, 298Y, 301Q, 302T, 305T, 306E, 309S, 310V, 315L, 316I, 317F, 323A, 325I, 326S, 327G, 328G, 329N, 330F, 331H, 333Q, 334P, 337I, 341T, 348E, 351N, 355R, 359K, 362N, 365L, 378G, 379I, 381D, 382G, 384M, 385I, 386P, 387Q, 389V, 391A, 392A, 393L, 394V, 395S, 396E, 398K, 399V, 400L, 401A, 412S, 413A, 414N, 415Q, 416E, 417D, 418H, 421M, 427R, 428K, 431T, 434D, 435H
CDD
cd00332 (PAL-HAL)

85D

tetramer interface
60G, 61F, 80N, 83Y, 84S, 85D, 86A, 87C, 88G, 89V, 90G, 111K, 139K, 140G, 153H, 156L, 241R, 242I, 245I, 246R, 248H, 251Q, 277Q, 279A, 280Y, 281S, 283R, 284C, 287Q, 288V, 294L, 295A, 298Y, 301Q, 302T, 305T, 306E, 309S, 310V, 315L, 316I, 317F, 323A, 325I, 326S, 327G, 328G, 329N, 330F, 331H, 333Q, 334P, 337I, 341T, 348E, 351N, 355R, 359K, 362N, 365L, 378G, 379I, 381D, 382G, 384M, 385I, 386P, 387Q, 389V, 391A, 392A, 393L, 394V, 395S, 396E, 398K, 399V, 400L, 401A, 412S, 413A, 414N, 415Q, 416E, 417D, 418H, 421M, 427R, 428K, 431T, 434D, 435H
CDD
cd00332 (PAL-HAL)

86A

tetramer interface
60G, 61F, 80N, 83Y, 84S, 85D, 86A, 87C, 88G, 89V, 90G, 111K, 139K, 140G, 153H, 156L, 241R, 242I, 245I, 246R, 248H, 251Q, 277Q, 279A, 280Y, 281S, 283R, 284C, 287Q, 288V, 294L, 295A, 298Y, 301Q, 302T, 305T, 306E, 309S, 310V, 315L, 316I, 317F, 323A, 325I, 326S, 327G, 328G, 329N, 330F, 331H, 333Q, 334P, 337I, 341T, 348E, 351N, 355R, 359K, 362N, 365L, 378G, 379I, 381D, 382G, 384M, 385I, 386P, 387Q, 389V, 391A, 392A, 393L, 394V, 395S, 396E, 398K, 399V, 400L, 401A, 412S, 413A, 414N, 415Q, 416E, 417D, 418H, 421M, 427R, 428K, 431T, 434D, 435H
CDD
cd00332 (PAL-HAL)

87C

tetramer interface
60G, 61F, 80N, 83Y, 84S, 85D, 86A, 87C, 88G, 89V, 90G, 111K, 139K, 140G, 153H, 156L, 241R, 242I, 245I, 246R, 248H, 251Q, 277Q, 279A, 280Y, 281S, 283R, 284C, 287Q, 288V, 294L, 295A, 298Y, 301Q, 302T, 305T, 306E, 309S, 310V, 315L, 316I, 317F, 323A, 325I, 326S, 327G, 328G, 329N, 330F, 331H, 333Q, 334P, 337I, 341T, 348E, 351N, 355R, 359K, 362N, 365L, 378G, 379I, 381D, 382G, 384M, 385I, 386P, 387Q, 389V, 391A, 392A, 393L, 394V, 395S, 396E, 398K, 399V, 400L, 401A, 412S, 413A, 414N, 415Q, 416E, 417D, 418H, 421M, 427R, 428K, 431T, 434D, 435H
CDD
cd00332 (PAL-HAL)

88G

tetramer interface
60G, 61F, 80N, 83Y, 84S, 85D, 86A, 87C, 88G, 89V, 90G, 111K, 139K, 140G, 153H, 156L, 241R, 242I, 245I, 246R, 248H, 251Q, 277Q, 279A, 280Y, 281S, 283R, 284C, 287Q, 288V, 294L, 295A, 298Y, 301Q, 302T, 305T, 306E, 309S, 310V, 315L, 316I, 317F, 323A, 325I, 326S, 327G, 328G, 329N, 330F, 331H, 333Q, 334P, 337I, 341T, 348E, 351N, 355R, 359K, 362N, 365L, 378G, 379I, 381D, 382G, 384M, 385I, 386P, 387Q, 389V, 391A, 392A, 393L, 394V, 395S, 396E, 398K, 399V, 400L, 401A, 412S, 413A, 414N, 415Q, 416E, 417D, 418H, 421M, 427R, 428K, 431T, 434D, 435H
CDD
cd00332 (PAL-HAL)

89V

tetramer interface
60G, 61F, 80N, 83Y, 84S, 85D, 86A, 87C, 88G, 89V, 90G, 111K, 139K, 140G, 153H, 156L, 241R, 242I, 245I, 246R, 248H, 251Q, 277Q, 279A, 280Y, 281S, 283R, 284C, 287Q, 288V, 294L, 295A, 298Y, 301Q, 302T, 305T, 306E, 309S, 310V, 315L, 316I, 317F, 323A, 325I, 326S, 327G, 328G, 329N, 330F, 331H, 333Q, 334P, 337I, 341T, 348E, 351N, 355R, 359K, 362N, 365L, 378G, 379I, 381D, 382G, 384M, 385I, 386P, 387Q, 389V, 391A, 392A, 393L, 394V, 395S, 396E, 398K, 399V, 400L, 401A, 412S, 413A, 414N, 415Q, 416E, 417D, 418H, 421M, 427R, 428K, 431T, 434D, 435H
CDD
cd00332 (PAL-HAL)

90G

tetramer interface
60G, 61F, 80N, 83Y, 84S, 85D, 86A, 87C, 88G, 89V, 90G, 111K, 139K, 140G, 153H, 156L, 241R, 242I, 245I, 246R, 248H, 251Q, 277Q, 279A, 280Y, 281S, 283R, 284C, 287Q, 288V, 294L, 295A, 298Y, 301Q, 302T, 305T, 306E, 309S, 310V, 315L, 316I, 317F, 323A, 325I, 326S, 327G, 328G, 329N, 330F, 331H, 333Q, 334P, 337I, 341T, 348E, 351N, 355R, 359K, 362N, 365L, 378G, 379I, 381D, 382G, 384M, 385I, 386P, 387Q, 389V, 391A, 392A, 393L, 394V, 395S, 396E, 398K, 399V, 400L, 401A, 412S, 413A, 414N, 415Q, 416E, 417D, 418H, 421M, 427R, 428K, 431T, 434D, 435H
CDD
cd00332 (PAL-HAL)

111K

tetramer interface
60G, 61F, 80N, 83Y, 84S, 85D, 86A, 87C, 88G, 89V, 90G, 111K, 139K, 140G, 153H, 156L, 241R, 242I, 245I, 246R, 248H, 251Q, 277Q, 279A, 280Y, 281S, 283R, 284C, 287Q, 288V, 294L, 295A, 298Y, 301Q, 302T, 305T, 306E, 309S, 310V, 315L, 316I, 317F, 323A, 325I, 326S, 327G, 328G, 329N, 330F, 331H, 333Q, 334P, 337I, 341T, 348E, 351N, 355R, 359K, 362N, 365L, 378G, 379I, 381D, 382G, 384M, 385I, 386P, 387Q, 389V, 391A, 392A, 393L, 394V, 395S, 396E, 398K, 399V, 400L, 401A, 412S, 413A, 414N, 415Q, 416E, 417D, 418H, 421M, 427R, 428K, 431T, 434D, 435H
CDD
cd00332 (PAL-HAL)

139K

tetramer interface
60G, 61F, 80N, 83Y, 84S, 85D, 86A, 87C, 88G, 89V, 90G, 111K, 139K, 140G, 153H, 156L, 241R, 242I, 245I, 246R, 248H, 251Q, 277Q, 279A, 280Y, 281S, 283R, 284C, 287Q, 288V, 294L, 295A, 298Y, 301Q, 302T, 305T, 306E, 309S, 310V, 315L, 316I, 317F, 323A, 325I, 326S, 327G, 328G, 329N, 330F, 331H, 333Q, 334P, 337I, 341T, 348E, 351N, 355R, 359K, 362N, 365L, 378G, 379I, 381D, 382G, 384M, 385I, 386P, 387Q, 389V, 391A, 392A, 393L, 394V, 395S, 396E, 398K, 399V, 400L, 401A, 412S, 413A, 414N, 415Q, 416E, 417D, 418H, 421M, 427R, 428K, 431T, 434D, 435H
CDD
cd00332 (PAL-HAL)

140G

tetramer interface
60G, 61F, 80N, 83Y, 84S, 85D, 86A, 87C, 88G, 89V, 90G, 111K, 139K, 140G, 153H, 156L, 241R, 242I, 245I, 246R, 248H, 251Q, 277Q, 279A, 280Y, 281S, 283R, 284C, 287Q, 288V, 294L, 295A, 298Y, 301Q, 302T, 305T, 306E, 309S, 310V, 315L, 316I, 317F, 323A, 325I, 326S, 327G, 328G, 329N, 330F, 331H, 333Q, 334P, 337I, 341T, 348E, 351N, 355R, 359K, 362N, 365L, 378G, 379I, 381D, 382G, 384M, 385I, 386P, 387Q, 389V, 391A, 392A, 393L, 394V, 395S, 396E, 398K, 399V, 400L, 401A, 412S, 413A, 414N, 415Q, 416E, 417D, 418H, 421M, 427R, 428K, 431T, 434D, 435H
CDD
cd00332 (PAL-HAL)

153H

tetramer interface
60G, 61F, 80N, 83Y, 84S, 85D, 86A, 87C, 88G, 89V, 90G, 111K, 139K, 140G, 153H, 156L, 241R, 242I, 245I, 246R, 248H, 251Q, 277Q, 279A, 280Y, 281S, 283R, 284C, 287Q, 288V, 294L, 295A, 298Y, 301Q, 302T, 305T, 306E, 309S, 310V, 315L, 316I, 317F, 323A, 325I, 326S, 327G, 328G, 329N, 330F, 331H, 333Q, 334P, 337I, 341T, 348E, 351N, 355R, 359K, 362N, 365L, 378G, 379I, 381D, 382G, 384M, 385I, 386P, 387Q, 389V, 391A, 392A, 393L, 394V, 395S, 396E, 398K, 399V, 400L, 401A, 412S, 413A, 414N, 415Q, 416E, 417D, 418H, 421M, 427R, 428K, 431T, 434D, 435H
CDD
cd00332 (PAL-HAL)

156L

tetramer interface
60G, 61F, 80N, 83Y, 84S, 85D, 86A, 87C, 88G, 89V, 90G, 111K, 139K, 140G, 153H, 156L, 241R, 242I, 245I, 246R, 248H, 251Q, 277Q, 279A, 280Y, 281S, 283R, 284C, 287Q, 288V, 294L, 295A, 298Y, 301Q, 302T, 305T, 306E, 309S, 310V, 315L, 316I, 317F, 323A, 325I, 326S, 327G, 328G, 329N, 330F, 331H, 333Q, 334P, 337I, 341T, 348E, 351N, 355R, 359K, 362N, 365L, 378G, 379I, 381D, 382G, 384M, 385I, 386P, 387Q, 389V, 391A, 392A, 393L, 394V, 395S, 396E, 398K, 399V, 400L, 401A, 412S, 413A, 414N, 415Q, 416E, 417D, 418H, 421M, 427R, 428K, 431T, 434D, 435H
CDD
cd00332 (PAL-HAL)

241R

tetramer interface
60G, 61F, 80N, 83Y, 84S, 85D, 86A, 87C, 88G, 89V, 90G, 111K, 139K, 140G, 153H, 156L, 241R, 242I, 245I, 246R, 248H, 251Q, 277Q, 279A, 280Y, 281S, 283R, 284C, 287Q, 288V, 294L, 295A, 298Y, 301Q, 302T, 305T, 306E, 309S, 310V, 315L, 316I, 317F, 323A, 325I, 326S, 327G, 328G, 329N, 330F, 331H, 333Q, 334P, 337I, 341T, 348E, 351N, 355R, 359K, 362N, 365L, 378G, 379I, 381D, 382G, 384M, 385I, 386P, 387Q, 389V, 391A, 392A, 393L, 394V, 395S, 396E, 398K, 399V, 400L, 401A, 412S, 413A, 414N, 415Q, 416E, 417D, 418H, 421M, 427R, 428K, 431T, 434D, 435H
CDD
cd00332 (PAL-HAL)

242I

tetramer interface
60G, 61F, 80N, 83Y, 84S, 85D, 86A, 87C, 88G, 89V, 90G, 111K, 139K, 140G, 153H, 156L, 241R, 242I, 245I, 246R, 248H, 251Q, 277Q, 279A, 280Y, 281S, 283R, 284C, 287Q, 288V, 294L, 295A, 298Y, 301Q, 302T, 305T, 306E, 309S, 310V, 315L, 316I, 317F, 323A, 325I, 326S, 327G, 328G, 329N, 330F, 331H, 333Q, 334P, 337I, 341T, 348E, 351N, 355R, 359K, 362N, 365L, 378G, 379I, 381D, 382G, 384M, 385I, 386P, 387Q, 389V, 391A, 392A, 393L, 394V, 395S, 396E, 398K, 399V, 400L, 401A, 412S, 413A, 414N, 415Q, 416E, 417D, 418H, 421M, 427R, 428K, 431T, 434D, 435H
CDD
cd00332 (PAL-HAL)

245I

tetramer interface
60G, 61F, 80N, 83Y, 84S, 85D, 86A, 87C, 88G, 89V, 90G, 111K, 139K, 140G, 153H, 156L, 241R, 242I, 245I, 246R, 248H, 251Q, 277Q, 279A, 280Y, 281S, 283R, 284C, 287Q, 288V, 294L, 295A, 298Y, 301Q, 302T, 305T, 306E, 309S, 310V, 315L, 316I, 317F, 323A, 325I, 326S, 327G, 328G, 329N, 330F, 331H, 333Q, 334P, 337I, 341T, 348E, 351N, 355R, 359K, 362N, 365L, 378G, 379I, 381D, 382G, 384M, 385I, 386P, 387Q, 389V, 391A, 392A, 393L, 394V, 395S, 396E, 398K, 399V, 400L, 401A, 412S, 413A, 414N, 415Q, 416E, 417D, 418H, 421M, 427R, 428K, 431T, 434D, 435H
CDD
cd00332 (PAL-HAL)

246R

tetramer interface
60G, 61F, 80N, 83Y, 84S, 85D, 86A, 87C, 88G, 89V, 90G, 111K, 139K, 140G, 153H, 156L, 241R, 242I, 245I, 246R, 248H, 251Q, 277Q, 279A, 280Y, 281S, 283R, 284C, 287Q, 288V, 294L, 295A, 298Y, 301Q, 302T, 305T, 306E, 309S, 310V, 315L, 316I, 317F, 323A, 325I, 326S, 327G, 328G, 329N, 330F, 331H, 333Q, 334P, 337I, 341T, 348E, 351N, 355R, 359K, 362N, 365L, 378G, 379I, 381D, 382G, 384M, 385I, 386P, 387Q, 389V, 391A, 392A, 393L, 394V, 395S, 396E, 398K, 399V, 400L, 401A, 412S, 413A, 414N, 415Q, 416E, 417D, 418H, 421M, 427R, 428K, 431T, 434D, 435H
CDD
cd00332 (PAL-HAL)

248H

tetramer interface
60G, 61F, 80N, 83Y, 84S, 85D, 86A, 87C, 88G, 89V, 90G, 111K, 139K, 140G, 153H, 156L, 241R, 242I, 245I, 246R, 248H, 251Q, 277Q, 279A, 280Y, 281S, 283R, 284C, 287Q, 288V, 294L, 295A, 298Y, 301Q, 302T, 305T, 306E, 309S, 310V, 315L, 316I, 317F, 323A, 325I, 326S, 327G, 328G, 329N, 330F, 331H, 333Q, 334P, 337I, 341T, 348E, 351N, 355R, 359K, 362N, 365L, 378G, 379I, 381D, 382G, 384M, 385I, 386P, 387Q, 389V, 391A, 392A, 393L, 394V, 395S, 396E, 398K, 399V, 400L, 401A, 412S, 413A, 414N, 415Q, 416E, 417D, 418H, 421M, 427R, 428K, 431T, 434D, 435H
CDD
cd00332 (PAL-HAL)

251Q

tetramer interface
60G, 61F, 80N, 83Y, 84S, 85D, 86A, 87C, 88G, 89V, 90G, 111K, 139K, 140G, 153H, 156L, 241R, 242I, 245I, 246R, 248H, 251Q, 277Q, 279A, 280Y, 281S, 283R, 284C, 287Q, 288V, 294L, 295A, 298Y, 301Q, 302T, 305T, 306E, 309S, 310V, 315L, 316I, 317F, 323A, 325I, 326S, 327G, 328G, 329N, 330F, 331H, 333Q, 334P, 337I, 341T, 348E, 351N, 355R, 359K, 362N, 365L, 378G, 379I, 381D, 382G, 384M, 385I, 386P, 387Q, 389V, 391A, 392A, 393L, 394V, 395S, 396E, 398K, 399V, 400L, 401A, 412S, 413A, 414N, 415Q, 416E, 417D, 418H, 421M, 427R, 428K, 431T, 434D, 435H
CDD
cd00332 (PAL-HAL)

277Q

tetramer interface
60G, 61F, 80N, 83Y, 84S, 85D, 86A, 87C, 88G, 89V, 90G, 111K, 139K, 140G, 153H, 156L, 241R, 242I, 245I, 246R, 248H, 251Q, 277Q, 279A, 280Y, 281S, 283R, 284C, 287Q, 288V, 294L, 295A, 298Y, 301Q, 302T, 305T, 306E, 309S, 310V, 315L, 316I, 317F, 323A, 325I, 326S, 327G, 328G, 329N, 330F, 331H, 333Q, 334P, 337I, 341T, 348E, 351N, 355R, 359K, 362N, 365L, 378G, 379I, 381D, 382G, 384M, 385I, 386P, 387Q, 389V, 391A, 392A, 393L, 394V, 395S, 396E, 398K, 399V, 400L, 401A, 412S, 413A, 414N, 415Q, 416E, 417D, 418H, 421M, 427R, 428K, 431T, 434D, 435H
CDD
cd00332 (PAL-HAL)

279A

tetramer interface
60G, 61F, 80N, 83Y, 84S, 85D, 86A, 87C, 88G, 89V, 90G, 111K, 139K, 140G, 153H, 156L, 241R, 242I, 245I, 246R, 248H, 251Q, 277Q, 279A, 280Y, 281S, 283R, 284C, 287Q, 288V, 294L, 295A, 298Y, 301Q, 302T, 305T, 306E, 309S, 310V, 315L, 316I, 317F, 323A, 325I, 326S, 327G, 328G, 329N, 330F, 331H, 333Q, 334P, 337I, 341T, 348E, 351N, 355R, 359K, 362N, 365L, 378G, 379I, 381D, 382G, 384M, 385I, 386P, 387Q, 389V, 391A, 392A, 393L, 394V, 395S, 396E, 398K, 399V, 400L, 401A, 412S, 413A, 414N, 415Q, 416E, 417D, 418H, 421M, 427R, 428K, 431T, 434D, 435H
CDD
cd00332 (PAL-HAL)

280Y

tetramer interface
60G, 61F, 80N, 83Y, 84S, 85D, 86A, 87C, 88G, 89V, 90G, 111K, 139K, 140G, 153H, 156L, 241R, 242I, 245I, 246R, 248H, 251Q, 277Q, 279A, 280Y, 281S, 283R, 284C, 287Q, 288V, 294L, 295A, 298Y, 301Q, 302T, 305T, 306E, 309S, 310V, 315L, 316I, 317F, 323A, 325I, 326S, 327G, 328G, 329N, 330F, 331H, 333Q, 334P, 337I, 341T, 348E, 351N, 355R, 359K, 362N, 365L, 378G, 379I, 381D, 382G, 384M, 385I, 386P, 387Q, 389V, 391A, 392A, 393L, 394V, 395S, 396E, 398K, 399V, 400L, 401A, 412S, 413A, 414N, 415Q, 416E, 417D, 418H, 421M, 427R, 428K, 431T, 434D, 435H
CDD
cd00332 (PAL-HAL)

281S

tetramer interface
60G, 61F, 80N, 83Y, 84S, 85D, 86A, 87C, 88G, 89V, 90G, 111K, 139K, 140G, 153H, 156L, 241R, 242I, 245I, 246R, 248H, 251Q, 277Q, 279A, 280Y, 281S, 283R, 284C, 287Q, 288V, 294L, 295A, 298Y, 301Q, 302T, 305T, 306E, 309S, 310V, 315L, 316I, 317F, 323A, 325I, 326S, 327G, 328G, 329N, 330F, 331H, 333Q, 334P, 337I, 341T, 348E, 351N, 355R, 359K, 362N, 365L, 378G, 379I, 381D, 382G, 384M, 385I, 386P, 387Q, 389V, 391A, 392A, 393L, 394V, 395S, 396E, 398K, 399V, 400L, 401A, 412S, 413A, 414N, 415Q, 416E, 417D, 418H, 421M, 427R, 428K, 431T, 434D, 435H
CDD
cd00332 (PAL-HAL)

283R

tetramer interface
60G, 61F, 80N, 83Y, 84S, 85D, 86A, 87C, 88G, 89V, 90G, 111K, 139K, 140G, 153H, 156L, 241R, 242I, 245I, 246R, 248H, 251Q, 277Q, 279A, 280Y, 281S, 283R, 284C, 287Q, 288V, 294L, 295A, 298Y, 301Q, 302T, 305T, 306E, 309S, 310V, 315L, 316I, 317F, 323A, 325I, 326S, 327G, 328G, 329N, 330F, 331H, 333Q, 334P, 337I, 341T, 348E, 351N, 355R, 359K, 362N, 365L, 378G, 379I, 381D, 382G, 384M, 385I, 386P, 387Q, 389V, 391A, 392A, 393L, 394V, 395S, 396E, 398K, 399V, 400L, 401A, 412S, 413A, 414N, 415Q, 416E, 417D, 418H, 421M, 427R, 428K, 431T, 434D, 435H
CDD
cd00332 (PAL-HAL)

284C

tetramer interface
60G, 61F, 80N, 83Y, 84S, 85D, 86A, 87C, 88G, 89V, 90G, 111K, 139K, 140G, 153H, 156L, 241R, 242I, 245I, 246R, 248H, 251Q, 277Q, 279A, 280Y, 281S, 283R, 284C, 287Q, 288V, 294L, 295A, 298Y, 301Q, 302T, 305T, 306E, 309S, 310V, 315L, 316I, 317F, 323A, 325I, 326S, 327G, 328G, 329N, 330F, 331H, 333Q, 334P, 337I, 341T, 348E, 351N, 355R, 359K, 362N, 365L, 378G, 379I, 381D, 382G, 384M, 385I, 386P, 387Q, 389V, 391A, 392A, 393L, 394V, 395S, 396E, 398K, 399V, 400L, 401A, 412S, 413A, 414N, 415Q, 416E, 417D, 418H, 421M, 427R, 428K, 431T, 434D, 435H
CDD
cd00332 (PAL-HAL)

287Q

tetramer interface
60G, 61F, 80N, 83Y, 84S, 85D, 86A, 87C, 88G, 89V, 90G, 111K, 139K, 140G, 153H, 156L, 241R, 242I, 245I, 246R, 248H, 251Q, 277Q, 279A, 280Y, 281S, 283R, 284C, 287Q, 288V, 294L, 295A, 298Y, 301Q, 302T, 305T, 306E, 309S, 310V, 315L, 316I, 317F, 323A, 325I, 326S, 327G, 328G, 329N, 330F, 331H, 333Q, 334P, 337I, 341T, 348E, 351N, 355R, 359K, 362N, 365L, 378G, 379I, 381D, 382G, 384M, 385I, 386P, 387Q, 389V, 391A, 392A, 393L, 394V, 395S, 396E, 398K, 399V, 400L, 401A, 412S, 413A, 414N, 415Q, 416E, 417D, 418H, 421M, 427R, 428K, 431T, 434D, 435H
CDD
cd00332 (PAL-HAL)

288V

tetramer interface
60G, 61F, 80N, 83Y, 84S, 85D, 86A, 87C, 88G, 89V, 90G, 111K, 139K, 140G, 153H, 156L, 241R, 242I, 245I, 246R, 248H, 251Q, 277Q, 279A, 280Y, 281S, 283R, 284C, 287Q, 288V, 294L, 295A, 298Y, 301Q, 302T, 305T, 306E, 309S, 310V, 315L, 316I, 317F, 323A, 325I, 326S, 327G, 328G, 329N, 330F, 331H, 333Q, 334P, 337I, 341T, 348E, 351N, 355R, 359K, 362N, 365L, 378G, 379I, 381D, 382G, 384M, 385I, 386P, 387Q, 389V, 391A, 392A, 393L, 394V, 395S, 396E, 398K, 399V, 400L, 401A, 412S, 413A, 414N, 415Q, 416E, 417D, 418H, 421M, 427R, 428K, 431T, 434D, 435H
CDD
cd00332 (PAL-HAL)

294L

tetramer interface
60G, 61F, 80N, 83Y, 84S, 85D, 86A, 87C, 88G, 89V, 90G, 111K, 139K, 140G, 153H, 156L, 241R, 242I, 245I, 246R, 248H, 251Q, 277Q, 279A, 280Y, 281S, 283R, 284C, 287Q, 288V, 294L, 295A, 298Y, 301Q, 302T, 305T, 306E, 309S, 310V, 315L, 316I, 317F, 323A, 325I, 326S, 327G, 328G, 329N, 330F, 331H, 333Q, 334P, 337I, 341T, 348E, 351N, 355R, 359K, 362N, 365L, 378G, 379I, 381D, 382G, 384M, 385I, 386P, 387Q, 389V, 391A, 392A, 393L, 394V, 395S, 396E, 398K, 399V, 400L, 401A, 412S, 413A, 414N, 415Q, 416E, 417D, 418H, 421M, 427R, 428K, 431T, 434D, 435H
CDD
cd00332 (PAL-HAL)

295A

tetramer interface
60G, 61F, 80N, 83Y, 84S, 85D, 86A, 87C, 88G, 89V, 90G, 111K, 139K, 140G, 153H, 156L, 241R, 242I, 245I, 246R, 248H, 251Q, 277Q, 279A, 280Y, 281S, 283R, 284C, 287Q, 288V, 294L, 295A, 298Y, 301Q, 302T, 305T, 306E, 309S, 310V, 315L, 316I, 317F, 323A, 325I, 326S, 327G, 328G, 329N, 330F, 331H, 333Q, 334P, 337I, 341T, 348E, 351N, 355R, 359K, 362N, 365L, 378G, 379I, 381D, 382G, 384M, 385I, 386P, 387Q, 389V, 391A, 392A, 393L, 394V, 395S, 396E, 398K, 399V, 400L, 401A, 412S, 413A, 414N, 415Q, 416E, 417D, 418H, 421M, 427R, 428K, 431T, 434D, 435H
CDD
cd00332 (PAL-HAL)

298Y

tetramer interface
60G, 61F, 80N, 83Y, 84S, 85D, 86A, 87C, 88G, 89V, 90G, 111K, 139K, 140G, 153H, 156L, 241R, 242I, 245I, 246R, 248H, 251Q, 277Q, 279A, 280Y, 281S, 283R, 284C, 287Q, 288V, 294L, 295A, 298Y, 301Q, 302T, 305T, 306E, 309S, 310V, 315L, 316I, 317F, 323A, 325I, 326S, 327G, 328G, 329N, 330F, 331H, 333Q, 334P, 337I, 341T, 348E, 351N, 355R, 359K, 362N, 365L, 378G, 379I, 381D, 382G, 384M, 385I, 386P, 387Q, 389V, 391A, 392A, 393L, 394V, 395S, 396E, 398K, 399V, 400L, 401A, 412S, 413A, 414N, 415Q, 416E, 417D, 418H, 421M, 427R, 428K, 431T, 434D, 435H
CDD
cd00332 (PAL-HAL)

301Q

tetramer interface
60G, 61F, 80N, 83Y, 84S, 85D, 86A, 87C, 88G, 89V, 90G, 111K, 139K, 140G, 153H, 156L, 241R, 242I, 245I, 246R, 248H, 251Q, 277Q, 279A, 280Y, 281S, 283R, 284C, 287Q, 288V, 294L, 295A, 298Y, 301Q, 302T, 305T, 306E, 309S, 310V, 315L, 316I, 317F, 323A, 325I, 326S, 327G, 328G, 329N, 330F, 331H, 333Q, 334P, 337I, 341T, 348E, 351N, 355R, 359K, 362N, 365L, 378G, 379I, 381D, 382G, 384M, 385I, 386P, 387Q, 389V, 391A, 392A, 393L, 394V, 395S, 396E, 398K, 399V, 400L, 401A, 412S, 413A, 414N, 415Q, 416E, 417D, 418H, 421M, 427R, 428K, 431T, 434D, 435H
CDD
cd00332 (PAL-HAL)

302T

tetramer interface
60G, 61F, 80N, 83Y, 84S, 85D, 86A, 87C, 88G, 89V, 90G, 111K, 139K, 140G, 153H, 156L, 241R, 242I, 245I, 246R, 248H, 251Q, 277Q, 279A, 280Y, 281S, 283R, 284C, 287Q, 288V, 294L, 295A, 298Y, 301Q, 302T, 305T, 306E, 309S, 310V, 315L, 316I, 317F, 323A, 325I, 326S, 327G, 328G, 329N, 330F, 331H, 333Q, 334P, 337I, 341T, 348E, 351N, 355R, 359K, 362N, 365L, 378G, 379I, 381D, 382G, 384M, 385I, 386P, 387Q, 389V, 391A, 392A, 393L, 394V, 395S, 396E, 398K, 399V, 400L, 401A, 412S, 413A, 414N, 415Q, 416E, 417D, 418H, 421M, 427R, 428K, 431T, 434D, 435H
CDD
cd00332 (PAL-HAL)

305T

tetramer interface
60G, 61F, 80N, 83Y, 84S, 85D, 86A, 87C, 88G, 89V, 90G, 111K, 139K, 140G, 153H, 156L, 241R, 242I, 245I, 246R, 248H, 251Q, 277Q, 279A, 280Y, 281S, 283R, 284C, 287Q, 288V, 294L, 295A, 298Y, 301Q, 302T, 305T, 306E, 309S, 310V, 315L, 316I, 317F, 323A, 325I, 326S, 327G, 328G, 329N, 330F, 331H, 333Q, 334P, 337I, 341T, 348E, 351N, 355R, 359K, 362N, 365L, 378G, 379I, 381D, 382G, 384M, 385I, 386P, 387Q, 389V, 391A, 392A, 393L, 394V, 395S, 396E, 398K, 399V, 400L, 401A, 412S, 413A, 414N, 415Q, 416E, 417D, 418H, 421M, 427R, 428K, 431T, 434D, 435H
CDD
cd00332 (PAL-HAL)

306E

tetramer interface
60G, 61F, 80N, 83Y, 84S, 85D, 86A, 87C, 88G, 89V, 90G, 111K, 139K, 140G, 153H, 156L, 241R, 242I, 245I, 246R, 248H, 251Q, 277Q, 279A, 280Y, 281S, 283R, 284C, 287Q, 288V, 294L, 295A, 298Y, 301Q, 302T, 305T, 306E, 309S, 310V, 315L, 316I, 317F, 323A, 325I, 326S, 327G, 328G, 329N, 330F, 331H, 333Q, 334P, 337I, 341T, 348E, 351N, 355R, 359K, 362N, 365L, 378G, 379I, 381D, 382G, 384M, 385I, 386P, 387Q, 389V, 391A, 392A, 393L, 394V, 395S, 396E, 398K, 399V, 400L, 401A, 412S, 413A, 414N, 415Q, 416E, 417D, 418H, 421M, 427R, 428K, 431T, 434D, 435H
CDD
cd00332 (PAL-HAL)

309S

tetramer interface
60G, 61F, 80N, 83Y, 84S, 85D, 86A, 87C, 88G, 89V, 90G, 111K, 139K, 140G, 153H, 156L, 241R, 242I, 245I, 246R, 248H, 251Q, 277Q, 279A, 280Y, 281S, 283R, 284C, 287Q, 288V, 294L, 295A, 298Y, 301Q, 302T, 305T, 306E, 309S, 310V, 315L, 316I, 317F, 323A, 325I, 326S, 327G, 328G, 329N, 330F, 331H, 333Q, 334P, 337I, 341T, 348E, 351N, 355R, 359K, 362N, 365L, 378G, 379I, 381D, 382G, 384M, 385I, 386P, 387Q, 389V, 391A, 392A, 393L, 394V, 395S, 396E, 398K, 399V, 400L, 401A, 412S, 413A, 414N, 415Q, 416E, 417D, 418H, 421M, 427R, 428K, 431T, 434D, 435H
CDD
cd00332 (PAL-HAL)

310V

tetramer interface
60G, 61F, 80N, 83Y, 84S, 85D, 86A, 87C, 88G, 89V, 90G, 111K, 139K, 140G, 153H, 156L, 241R, 242I, 245I, 246R, 248H, 251Q, 277Q, 279A, 280Y, 281S, 283R, 284C, 287Q, 288V, 294L, 295A, 298Y, 301Q, 302T, 305T, 306E, 309S, 310V, 315L, 316I, 317F, 323A, 325I, 326S, 327G, 328G, 329N, 330F, 331H, 333Q, 334P, 337I, 341T, 348E, 351N, 355R, 359K, 362N, 365L, 378G, 379I, 381D, 382G, 384M, 385I, 386P, 387Q, 389V, 391A, 392A, 393L, 394V, 395S, 396E, 398K, 399V, 400L, 401A, 412S, 413A, 414N, 415Q, 416E, 417D, 418H, 421M, 427R, 428K, 431T, 434D, 435H
CDD
cd00332 (PAL-HAL)

315L

tetramer interface
60G, 61F, 80N, 83Y, 84S, 85D, 86A, 87C, 88G, 89V, 90G, 111K, 139K, 140G, 153H, 156L, 241R, 242I, 245I, 246R, 248H, 251Q, 277Q, 279A, 280Y, 281S, 283R, 284C, 287Q, 288V, 294L, 295A, 298Y, 301Q, 302T, 305T, 306E, 309S, 310V, 315L, 316I, 317F, 323A, 325I, 326S, 327G, 328G, 329N, 330F, 331H, 333Q, 334P, 337I, 341T, 348E, 351N, 355R, 359K, 362N, 365L, 378G, 379I, 381D, 382G, 384M, 385I, 386P, 387Q, 389V, 391A, 392A, 393L, 394V, 395S, 396E, 398K, 399V, 400L, 401A, 412S, 413A, 414N, 415Q, 416E, 417D, 418H, 421M, 427R, 428K, 431T, 434D, 435H
CDD
cd00332 (PAL-HAL)

316I

tetramer interface
60G, 61F, 80N, 83Y, 84S, 85D, 86A, 87C, 88G, 89V, 90G, 111K, 139K, 140G, 153H, 156L, 241R, 242I, 245I, 246R, 248H, 251Q, 277Q, 279A, 280Y, 281S, 283R, 284C, 287Q, 288V, 294L, 295A, 298Y, 301Q, 302T, 305T, 306E, 309S, 310V, 315L, 316I, 317F, 323A, 325I, 326S, 327G, 328G, 329N, 330F, 331H, 333Q, 334P, 337I, 341T, 348E, 351N, 355R, 359K, 362N, 365L, 378G, 379I, 381D, 382G, 384M, 385I, 386P, 387Q, 389V, 391A, 392A, 393L, 394V, 395S, 396E, 398K, 399V, 400L, 401A, 412S, 413A, 414N, 415Q, 416E, 417D, 418H, 421M, 427R, 428K, 431T, 434D, 435H
CDD
cd00332 (PAL-HAL)

317F

tetramer interface
60G, 61F, 80N, 83Y, 84S, 85D, 86A, 87C, 88G, 89V, 90G, 111K, 139K, 140G, 153H, 156L, 241R, 242I, 245I, 246R, 248H, 251Q, 277Q, 279A, 280Y, 281S, 283R, 284C, 287Q, 288V, 294L, 295A, 298Y, 301Q, 302T, 305T, 306E, 309S, 310V, 315L, 316I, 317F, 323A, 325I, 326S, 327G, 328G, 329N, 330F, 331H, 333Q, 334P, 337I, 341T, 348E, 351N, 355R, 359K, 362N, 365L, 378G, 379I, 381D, 382G, 384M, 385I, 386P, 387Q, 389V, 391A, 392A, 393L, 394V, 395S, 396E, 398K, 399V, 400L, 401A, 412S, 413A, 414N, 415Q, 416E, 417D, 418H, 421M, 427R, 428K, 431T, 434D, 435H
CDD
cd00332 (PAL-HAL)

323A

tetramer interface
60G, 61F, 80N, 83Y, 84S, 85D, 86A, 87C, 88G, 89V, 90G, 111K, 139K, 140G, 153H, 156L, 241R, 242I, 245I, 246R, 248H, 251Q, 277Q, 279A, 280Y, 281S, 283R, 284C, 287Q, 288V, 294L, 295A, 298Y, 301Q, 302T, 305T, 306E, 309S, 310V, 315L, 316I, 317F, 323A, 325I, 326S, 327G, 328G, 329N, 330F, 331H, 333Q, 334P, 337I, 341T, 348E, 351N, 355R, 359K, 362N, 365L, 378G, 379I, 381D, 382G, 384M, 385I, 386P, 387Q, 389V, 391A, 392A, 393L, 394V, 395S, 396E, 398K, 399V, 400L, 401A, 412S, 413A, 414N, 415Q, 416E, 417D, 418H, 421M, 427R, 428K, 431T, 434D, 435H
CDD
cd00332 (PAL-HAL)

325I

tetramer interface
60G, 61F, 80N, 83Y, 84S, 85D, 86A, 87C, 88G, 89V, 90G, 111K, 139K, 140G, 153H, 156L, 241R, 242I, 245I, 246R, 248H, 251Q, 277Q, 279A, 280Y, 281S, 283R, 284C, 287Q, 288V, 294L, 295A, 298Y, 301Q, 302T, 305T, 306E, 309S, 310V, 315L, 316I, 317F, 323A, 325I, 326S, 327G, 328G, 329N, 330F, 331H, 333Q, 334P, 337I, 341T, 348E, 351N, 355R, 359K, 362N, 365L, 378G, 379I, 381D, 382G, 384M, 385I, 386P, 387Q, 389V, 391A, 392A, 393L, 394V, 395S, 396E, 398K, 399V, 400L, 401A, 412S, 413A, 414N, 415Q, 416E, 417D, 418H, 421M, 427R, 428K, 431T, 434D, 435H
CDD
cd00332 (PAL-HAL)

326S

tetramer interface
60G, 61F, 80N, 83Y, 84S, 85D, 86A, 87C, 88G, 89V, 90G, 111K, 139K, 140G, 153H, 156L, 241R, 242I, 245I, 246R, 248H, 251Q, 277Q, 279A, 280Y, 281S, 283R, 284C, 287Q, 288V, 294L, 295A, 298Y, 301Q, 302T, 305T, 306E, 309S, 310V, 315L, 316I, 317F, 323A, 325I, 326S, 327G, 328G, 329N, 330F, 331H, 333Q, 334P, 337I, 341T, 348E, 351N, 355R, 359K, 362N, 365L, 378G, 379I, 381D, 382G, 384M, 385I, 386P, 387Q, 389V, 391A, 392A, 393L, 394V, 395S, 396E, 398K, 399V, 400L, 401A, 412S, 413A, 414N, 415Q, 416E, 417D, 418H, 421M, 427R, 428K, 431T, 434D, 435H
CDD
cd00332 (PAL-HAL)

327G

tetramer interface
60G, 61F, 80N, 83Y, 84S, 85D, 86A, 87C, 88G, 89V, 90G, 111K, 139K, 140G, 153H, 156L, 241R, 242I, 245I, 246R, 248H, 251Q, 277Q, 279A, 280Y, 281S, 283R, 284C, 287Q, 288V, 294L, 295A, 298Y, 301Q, 302T, 305T, 306E, 309S, 310V, 315L, 316I, 317F, 323A, 325I, 326S, 327G, 328G, 329N, 330F, 331H, 333Q, 334P, 337I, 341T, 348E, 351N, 355R, 359K, 362N, 365L, 378G, 379I, 381D, 382G, 384M, 385I, 386P, 387Q, 389V, 391A, 392A, 393L, 394V, 395S, 396E, 398K, 399V, 400L, 401A, 412S, 413A, 414N, 415Q, 416E, 417D, 418H, 421M, 427R, 428K, 431T, 434D, 435H
CDD
cd00332 (PAL-HAL)

328G

tetramer interface
60G, 61F, 80N, 83Y, 84S, 85D, 86A, 87C, 88G, 89V, 90G, 111K, 139K, 140G, 153H, 156L, 241R, 242I, 245I, 246R, 248H, 251Q, 277Q, 279A, 280Y, 281S, 283R, 284C, 287Q, 288V, 294L, 295A, 298Y, 301Q, 302T, 305T, 306E, 309S, 310V, 315L, 316I, 317F, 323A, 325I, 326S, 327G, 328G, 329N, 330F, 331H, 333Q, 334P, 337I, 341T, 348E, 351N, 355R, 359K, 362N, 365L, 378G, 379I, 381D, 382G, 384M, 385I, 386P, 387Q, 389V, 391A, 392A, 393L, 394V, 395S, 396E, 398K, 399V, 400L, 401A, 412S, 413A, 414N, 415Q, 416E, 417D, 418H, 421M, 427R, 428K, 431T, 434D, 435H
CDD
cd00332 (PAL-HAL)

329N

tetramer interface
60G, 61F, 80N, 83Y, 84S, 85D, 86A, 87C, 88G, 89V, 90G, 111K, 139K, 140G, 153H, 156L, 241R, 242I, 245I, 246R, 248H, 251Q, 277Q, 279A, 280Y, 281S, 283R, 284C, 287Q, 288V, 294L, 295A, 298Y, 301Q, 302T, 305T, 306E, 309S, 310V, 315L, 316I, 317F, 323A, 325I, 326S, 327G, 328G, 329N, 330F, 331H, 333Q, 334P, 337I, 341T, 348E, 351N, 355R, 359K, 362N, 365L, 378G, 379I, 381D, 382G, 384M, 385I, 386P, 387Q, 389V, 391A, 392A, 393L, 394V, 395S, 396E, 398K, 399V, 400L, 401A, 412S, 413A, 414N, 415Q, 416E, 417D, 418H, 421M, 427R, 428K, 431T, 434D, 435H
CDD
cd00332 (PAL-HAL)

330F

tetramer interface
60G, 61F, 80N, 83Y, 84S, 85D, 86A, 87C, 88G, 89V, 90G, 111K, 139K, 140G, 153H, 156L, 241R, 242I, 245I, 246R, 248H, 251Q, 277Q, 279A, 280Y, 281S, 283R, 284C, 287Q, 288V, 294L, 295A, 298Y, 301Q, 302T, 305T, 306E, 309S, 310V, 315L, 316I, 317F, 323A, 325I, 326S, 327G, 328G, 329N, 330F, 331H, 333Q, 334P, 337I, 341T, 348E, 351N, 355R, 359K, 362N, 365L, 378G, 379I, 381D, 382G, 384M, 385I, 386P, 387Q, 389V, 391A, 392A, 393L, 394V, 395S, 396E, 398K, 399V, 400L, 401A, 412S, 413A, 414N, 415Q, 416E, 417D, 418H, 421M, 427R, 428K, 431T, 434D, 435H
CDD
cd00332 (PAL-HAL)

331H

tetramer interface
60G, 61F, 80N, 83Y, 84S, 85D, 86A, 87C, 88G, 89V, 90G, 111K, 139K, 140G, 153H, 156L, 241R, 242I, 245I, 246R, 248H, 251Q, 277Q, 279A, 280Y, 281S, 283R, 284C, 287Q, 288V, 294L, 295A, 298Y, 301Q, 302T, 305T, 306E, 309S, 310V, 315L, 316I, 317F, 323A, 325I, 326S, 327G, 328G, 329N, 330F, 331H, 333Q, 334P, 337I, 341T, 348E, 351N, 355R, 359K, 362N, 365L, 378G, 379I, 381D, 382G, 384M, 385I, 386P, 387Q, 389V, 391A, 392A, 393L, 394V, 395S, 396E, 398K, 399V, 400L, 401A, 412S, 413A, 414N, 415Q, 416E, 417D, 418H, 421M, 427R, 428K, 431T, 434D, 435H
CDD
cd00332 (PAL-HAL)

333Q

tetramer interface
60G, 61F, 80N, 83Y, 84S, 85D, 86A, 87C, 88G, 89V, 90G, 111K, 139K, 140G, 153H, 156L, 241R, 242I, 245I, 246R, 248H, 251Q, 277Q, 279A, 280Y, 281S, 283R, 284C, 287Q, 288V, 294L, 295A, 298Y, 301Q, 302T, 305T, 306E, 309S, 310V, 315L, 316I, 317F, 323A, 325I, 326S, 327G, 328G, 329N, 330F, 331H, 333Q, 334P, 337I, 341T, 348E, 351N, 355R, 359K, 362N, 365L, 378G, 379I, 381D, 382G, 384M, 385I, 386P, 387Q, 389V, 391A, 392A, 393L, 394V, 395S, 396E, 398K, 399V, 400L, 401A, 412S, 413A, 414N, 415Q, 416E, 417D, 418H, 421M, 427R, 428K, 431T, 434D, 435H
CDD
cd00332 (PAL-HAL)

334P

tetramer interface
60G, 61F, 80N, 83Y, 84S, 85D, 86A, 87C, 88G, 89V, 90G, 111K, 139K, 140G, 153H, 156L, 241R, 242I, 245I, 246R, 248H, 251Q, 277Q, 279A, 280Y, 281S, 283R, 284C, 287Q, 288V, 294L, 295A, 298Y, 301Q, 302T, 305T, 306E, 309S, 310V, 315L, 316I, 317F, 323A, 325I, 326S, 327G, 328G, 329N, 330F, 331H, 333Q, 334P, 337I, 341T, 348E, 351N, 355R, 359K, 362N, 365L, 378G, 379I, 381D, 382G, 384M, 385I, 386P, 387Q, 389V, 391A, 392A, 393L, 394V, 395S, 396E, 398K, 399V, 400L, 401A, 412S, 413A, 414N, 415Q, 416E, 417D, 418H, 421M, 427R, 428K, 431T, 434D, 435H
CDD
cd00332 (PAL-HAL)

337I

tetramer interface
60G, 61F, 80N, 83Y, 84S, 85D, 86A, 87C, 88G, 89V, 90G, 111K, 139K, 140G, 153H, 156L, 241R, 242I, 245I, 246R, 248H, 251Q, 277Q, 279A, 280Y, 281S, 283R, 284C, 287Q, 288V, 294L, 295A, 298Y, 301Q, 302T, 305T, 306E, 309S, 310V, 315L, 316I, 317F, 323A, 325I, 326S, 327G, 328G, 329N, 330F, 331H, 333Q, 334P, 337I, 341T, 348E, 351N, 355R, 359K, 362N, 365L, 378G, 379I, 381D, 382G, 384M, 385I, 386P, 387Q, 389V, 391A, 392A, 393L, 394V, 395S, 396E, 398K, 399V, 400L, 401A, 412S, 413A, 414N, 415Q, 416E, 417D, 418H, 421M, 427R, 428K, 431T, 434D, 435H
CDD
cd00332 (PAL-HAL)

341T

tetramer interface
60G, 61F, 80N, 83Y, 84S, 85D, 86A, 87C, 88G, 89V, 90G, 111K, 139K, 140G, 153H, 156L, 241R, 242I, 245I, 246R, 248H, 251Q, 277Q, 279A, 280Y, 281S, 283R, 284C, 287Q, 288V, 294L, 295A, 298Y, 301Q, 302T, 305T, 306E, 309S, 310V, 315L, 316I, 317F, 323A, 325I, 326S, 327G, 328G, 329N, 330F, 331H, 333Q, 334P, 337I, 341T, 348E, 351N, 355R, 359K, 362N, 365L, 378G, 379I, 381D, 382G, 384M, 385I, 386P, 387Q, 389V, 391A, 392A, 393L, 394V, 395S, 396E, 398K, 399V, 400L, 401A, 412S, 413A, 414N, 415Q, 416E, 417D, 418H, 421M, 427R, 428K, 431T, 434D, 435H
CDD
cd00332 (PAL-HAL)

348E

tetramer interface
60G, 61F, 80N, 83Y, 84S, 85D, 86A, 87C, 88G, 89V, 90G, 111K, 139K, 140G, 153H, 156L, 241R, 242I, 245I, 246R, 248H, 251Q, 277Q, 279A, 280Y, 281S, 283R, 284C, 287Q, 288V, 294L, 295A, 298Y, 301Q, 302T, 305T, 306E, 309S, 310V, 315L, 316I, 317F, 323A, 325I, 326S, 327G, 328G, 329N, 330F, 331H, 333Q, 334P, 337I, 341T, 348E, 351N, 355R, 359K, 362N, 365L, 378G, 379I, 381D, 382G, 384M, 385I, 386P, 387Q, 389V, 391A, 392A, 393L, 394V, 395S, 396E, 398K, 399V, 400L, 401A, 412S, 413A, 414N, 415Q, 416E, 417D, 418H, 421M, 427R, 428K, 431T, 434D, 435H
CDD
cd00332 (PAL-HAL)

351N

tetramer interface
60G, 61F, 80N, 83Y, 84S, 85D, 86A, 87C, 88G, 89V, 90G, 111K, 139K, 140G, 153H, 156L, 241R, 242I, 245I, 246R, 248H, 251Q, 277Q, 279A, 280Y, 281S, 283R, 284C, 287Q, 288V, 294L, 295A, 298Y, 301Q, 302T, 305T, 306E, 309S, 310V, 315L, 316I, 317F, 323A, 325I, 326S, 327G, 328G, 329N, 330F, 331H, 333Q, 334P, 337I, 341T, 348E, 351N, 355R, 359K, 362N, 365L, 378G, 379I, 381D, 382G, 384M, 385I, 386P, 387Q, 389V, 391A, 392A, 393L, 394V, 395S, 396E, 398K, 399V, 400L, 401A, 412S, 413A, 414N, 415Q, 416E, 417D, 418H, 421M, 427R, 428K, 431T, 434D, 435H
CDD
cd00332 (PAL-HAL)

355R

tetramer interface
60G, 61F, 80N, 83Y, 84S, 85D, 86A, 87C, 88G, 89V, 90G, 111K, 139K, 140G, 153H, 156L, 241R, 242I, 245I, 246R, 248H, 251Q, 277Q, 279A, 280Y, 281S, 283R, 284C, 287Q, 288V, 294L, 295A, 298Y, 301Q, 302T, 305T, 306E, 309S, 310V, 315L, 316I, 317F, 323A, 325I, 326S, 327G, 328G, 329N, 330F, 331H, 333Q, 334P, 337I, 341T, 348E, 351N, 355R, 359K, 362N, 365L, 378G, 379I, 381D, 382G, 384M, 385I, 386P, 387Q, 389V, 391A, 392A, 393L, 394V, 395S, 396E, 398K, 399V, 400L, 401A, 412S, 413A, 414N, 415Q, 416E, 417D, 418H, 421M, 427R, 428K, 431T, 434D, 435H
CDD
cd00332 (PAL-HAL)

359K

tetramer interface
60G, 61F, 80N, 83Y, 84S, 85D, 86A, 87C, 88G, 89V, 90G, 111K, 139K, 140G, 153H, 156L, 241R, 242I, 245I, 246R, 248H, 251Q, 277Q, 279A, 280Y, 281S, 283R, 284C, 287Q, 288V, 294L, 295A, 298Y, 301Q, 302T, 305T, 306E, 309S, 310V, 315L, 316I, 317F, 323A, 325I, 326S, 327G, 328G, 329N, 330F, 331H, 333Q, 334P, 337I, 341T, 348E, 351N, 355R, 359K, 362N, 365L, 378G, 379I, 381D, 382G, 384M, 385I, 386P, 387Q, 389V, 391A, 392A, 393L, 394V, 395S, 396E, 398K, 399V, 400L, 401A, 412S, 413A, 414N, 415Q, 416E, 417D, 418H, 421M, 427R, 428K, 431T, 434D, 435H
CDD
cd00332 (PAL-HAL)

362N

tetramer interface
60G, 61F, 80N, 83Y, 84S, 85D, 86A, 87C, 88G, 89V, 90G, 111K, 139K, 140G, 153H, 156L, 241R, 242I, 245I, 246R, 248H, 251Q, 277Q, 279A, 280Y, 281S, 283R, 284C, 287Q, 288V, 294L, 295A, 298Y, 301Q, 302T, 305T, 306E, 309S, 310V, 315L, 316I, 317F, 323A, 325I, 326S, 327G, 328G, 329N, 330F, 331H, 333Q, 334P, 337I, 341T, 348E, 351N, 355R, 359K, 362N, 365L, 378G, 379I, 381D, 382G, 384M, 385I, 386P, 387Q, 389V, 391A, 392A, 393L, 394V, 395S, 396E, 398K, 399V, 400L, 401A, 412S, 413A, 414N, 415Q, 416E, 417D, 418H, 421M, 427R, 428K, 431T, 434D, 435H
CDD
cd00332 (PAL-HAL)

365L

tetramer interface
60G, 61F, 80N, 83Y, 84S, 85D, 86A, 87C, 88G, 89V, 90G, 111K, 139K, 140G, 153H, 156L, 241R, 242I, 245I, 246R, 248H, 251Q, 277Q, 279A, 280Y, 281S, 283R, 284C, 287Q, 288V, 294L, 295A, 298Y, 301Q, 302T, 305T, 306E, 309S, 310V, 315L, 316I, 317F, 323A, 325I, 326S, 327G, 328G, 329N, 330F, 331H, 333Q, 334P, 337I, 341T, 348E, 351N, 355R, 359K, 362N, 365L, 378G, 379I, 381D, 382G, 384M, 385I, 386P, 387Q, 389V, 391A, 392A, 393L, 394V, 395S, 396E, 398K, 399V, 400L, 401A, 412S, 413A, 414N, 415Q, 416E, 417D, 418H, 421M, 427R, 428K, 431T, 434D, 435H
CDD
cd00332 (PAL-HAL)

378G

tetramer interface
60G, 61F, 80N, 83Y, 84S, 85D, 86A, 87C, 88G, 89V, 90G, 111K, 139K, 140G, 153H, 156L, 241R, 242I, 245I, 246R, 248H, 251Q, 277Q, 279A, 280Y, 281S, 283R, 284C, 287Q, 288V, 294L, 295A, 298Y, 301Q, 302T, 305T, 306E, 309S, 310V, 315L, 316I, 317F, 323A, 325I, 326S, 327G, 328G, 329N, 330F, 331H, 333Q, 334P, 337I, 341T, 348E, 351N, 355R, 359K, 362N, 365L, 378G, 379I, 381D, 382G, 384M, 385I, 386P, 387Q, 389V, 391A, 392A, 393L, 394V, 395S, 396E, 398K, 399V, 400L, 401A, 412S, 413A, 414N, 415Q, 416E, 417D, 418H, 421M, 427R, 428K, 431T, 434D, 435H
CDD
cd00332 (PAL-HAL)

379I

tetramer interface
60G, 61F, 80N, 83Y, 84S, 85D, 86A, 87C, 88G, 89V, 90G, 111K, 139K, 140G, 153H, 156L, 241R, 242I, 245I, 246R, 248H, 251Q, 277Q, 279A, 280Y, 281S, 283R, 284C, 287Q, 288V, 294L, 295A, 298Y, 301Q, 302T, 305T, 306E, 309S, 310V, 315L, 316I, 317F, 323A, 325I, 326S, 327G, 328G, 329N, 330F, 331H, 333Q, 334P, 337I, 341T, 348E, 351N, 355R, 359K, 362N, 365L, 378G, 379I, 381D, 382G, 384M, 385I, 386P, 387Q, 389V, 391A, 392A, 393L, 394V, 395S, 396E, 398K, 399V, 400L, 401A, 412S, 413A, 414N, 415Q, 416E, 417D, 418H, 421M, 427R, 428K, 431T, 434D, 435H
CDD
cd00332 (PAL-HAL)

381D

tetramer interface
60G, 61F, 80N, 83Y, 84S, 85D, 86A, 87C, 88G, 89V, 90G, 111K, 139K, 140G, 153H, 156L, 241R, 242I, 245I, 246R, 248H, 251Q, 277Q, 279A, 280Y, 281S, 283R, 284C, 287Q, 288V, 294L, 295A, 298Y, 301Q, 302T, 305T, 306E, 309S, 310V, 315L, 316I, 317F, 323A, 325I, 326S, 327G, 328G, 329N, 330F, 331H, 333Q, 334P, 337I, 341T, 348E, 351N, 355R, 359K, 362N, 365L, 378G, 379I, 381D, 382G, 384M, 385I, 386P, 387Q, 389V, 391A, 392A, 393L, 394V, 395S, 396E, 398K, 399V, 400L, 401A, 412S, 413A, 414N, 415Q, 416E, 417D, 418H, 421M, 427R, 428K, 431T, 434D, 435H
CDD
cd00332 (PAL-HAL)

382G

tetramer interface
60G, 61F, 80N, 83Y, 84S, 85D, 86A, 87C, 88G, 89V, 90G, 111K, 139K, 140G, 153H, 156L, 241R, 242I, 245I, 246R, 248H, 251Q, 277Q, 279A, 280Y, 281S, 283R, 284C, 287Q, 288V, 294L, 295A, 298Y, 301Q, 302T, 305T, 306E, 309S, 310V, 315L, 316I, 317F, 323A, 325I, 326S, 327G, 328G, 329N, 330F, 331H, 333Q, 334P, 337I, 341T, 348E, 351N, 355R, 359K, 362N, 365L, 378G, 379I, 381D, 382G, 384M, 385I, 386P, 387Q, 389V, 391A, 392A, 393L, 394V, 395S, 396E, 398K, 399V, 400L, 401A, 412S, 413A, 414N, 415Q, 416E, 417D, 418H, 421M, 427R, 428K, 431T, 434D, 435H
CDD
cd00332 (PAL-HAL)

384M

tetramer interface
60G, 61F, 80N, 83Y, 84S, 85D, 86A, 87C, 88G, 89V, 90G, 111K, 139K, 140G, 153H, 156L, 241R, 242I, 245I, 246R, 248H, 251Q, 277Q, 279A, 280Y, 281S, 283R, 284C, 287Q, 288V, 294L, 295A, 298Y, 301Q, 302T, 305T, 306E, 309S, 310V, 315L, 316I, 317F, 323A, 325I, 326S, 327G, 328G, 329N, 330F, 331H, 333Q, 334P, 337I, 341T, 348E, 351N, 355R, 359K, 362N, 365L, 378G, 379I, 381D, 382G, 384M, 385I, 386P, 387Q, 389V, 391A, 392A, 393L, 394V, 395S, 396E, 398K, 399V, 400L, 401A, 412S, 413A, 414N, 415Q, 416E, 417D, 418H, 421M, 427R, 428K, 431T, 434D, 435H
CDD
cd00332 (PAL-HAL)

385I

tetramer interface
60G, 61F, 80N, 83Y, 84S, 85D, 86A, 87C, 88G, 89V, 90G, 111K, 139K, 140G, 153H, 156L, 241R, 242I, 245I, 246R, 248H, 251Q, 277Q, 279A, 280Y, 281S, 283R, 284C, 287Q, 288V, 294L, 295A, 298Y, 301Q, 302T, 305T, 306E, 309S, 310V, 315L, 316I, 317F, 323A, 325I, 326S, 327G, 328G, 329N, 330F, 331H, 333Q, 334P, 337I, 341T, 348E, 351N, 355R, 359K, 362N, 365L, 378G, 379I, 381D, 382G, 384M, 385I, 386P, 387Q, 389V, 391A, 392A, 393L, 394V, 395S, 396E, 398K, 399V, 400L, 401A, 412S, 413A, 414N, 415Q, 416E, 417D, 418H, 421M, 427R, 428K, 431T, 434D, 435H
CDD
cd00332 (PAL-HAL)

386P

tetramer interface
60G, 61F, 80N, 83Y, 84S, 85D, 86A, 87C, 88G, 89V, 90G, 111K, 139K, 140G, 153H, 156L, 241R, 242I, 245I, 246R, 248H, 251Q, 277Q, 279A, 280Y, 281S, 283R, 284C, 287Q, 288V, 294L, 295A, 298Y, 301Q, 302T, 305T, 306E, 309S, 310V, 315L, 316I, 317F, 323A, 325I, 326S, 327G, 328G, 329N, 330F, 331H, 333Q, 334P, 337I, 341T, 348E, 351N, 355R, 359K, 362N, 365L, 378G, 379I, 381D, 382G, 384M, 385I, 386P, 387Q, 389V, 391A, 392A, 393L, 394V, 395S, 396E, 398K, 399V, 400L, 401A, 412S, 413A, 414N, 415Q, 416E, 417D, 418H, 421M, 427R, 428K, 431T, 434D, 435H
CDD
cd00332 (PAL-HAL)

387Q

tetramer interface
60G, 61F, 80N, 83Y, 84S, 85D, 86A, 87C, 88G, 89V, 90G, 111K, 139K, 140G, 153H, 156L, 241R, 242I, 245I, 246R, 248H, 251Q, 277Q, 279A, 280Y, 281S, 283R, 284C, 287Q, 288V, 294L, 295A, 298Y, 301Q, 302T, 305T, 306E, 309S, 310V, 315L, 316I, 317F, 323A, 325I, 326S, 327G, 328G, 329N, 330F, 331H, 333Q, 334P, 337I, 341T, 348E, 351N, 355R, 359K, 362N, 365L, 378G, 379I, 381D, 382G, 384M, 385I, 386P, 387Q, 389V, 391A, 392A, 393L, 394V, 395S, 396E, 398K, 399V, 400L, 401A, 412S, 413A, 414N, 415Q, 416E, 417D, 418H, 421M, 427R, 428K, 431T, 434D, 435H
CDD
cd00332 (PAL-HAL)

389V

tetramer interface
60G, 61F, 80N, 83Y, 84S, 85D, 86A, 87C, 88G, 89V, 90G, 111K, 139K, 140G, 153H, 156L, 241R, 242I, 245I, 246R, 248H, 251Q, 277Q, 279A, 280Y, 281S, 283R, 284C, 287Q, 288V, 294L, 295A, 298Y, 301Q, 302T, 305T, 306E, 309S, 310V, 315L, 316I, 317F, 323A, 325I, 326S, 327G, 328G, 329N, 330F, 331H, 333Q, 334P, 337I, 341T, 348E, 351N, 355R, 359K, 362N, 365L, 378G, 379I, 381D, 382G, 384M, 385I, 386P, 387Q, 389V, 391A, 392A, 393L, 394V, 395S, 396E, 398K, 399V, 400L, 401A, 412S, 413A, 414N, 415Q, 416E, 417D, 418H, 421M, 427R, 428K, 431T, 434D, 435H
CDD
cd00332 (PAL-HAL)

391A

tetramer interface
60G, 61F, 80N, 83Y, 84S, 85D, 86A, 87C, 88G, 89V, 90G, 111K, 139K, 140G, 153H, 156L, 241R, 242I, 245I, 246R, 248H, 251Q, 277Q, 279A, 280Y, 281S, 283R, 284C, 287Q, 288V, 294L, 295A, 298Y, 301Q, 302T, 305T, 306E, 309S, 310V, 315L, 316I, 317F, 323A, 325I, 326S, 327G, 328G, 329N, 330F, 331H, 333Q, 334P, 337I, 341T, 348E, 351N, 355R, 359K, 362N, 365L, 378G, 379I, 381D, 382G, 384M, 385I, 386P, 387Q, 389V, 391A, 392A, 393L, 394V, 395S, 396E, 398K, 399V, 400L, 401A, 412S, 413A, 414N, 415Q, 416E, 417D, 418H, 421M, 427R, 428K, 431T, 434D, 435H
CDD
cd00332 (PAL-HAL)

392A

tetramer interface
60G, 61F, 80N, 83Y, 84S, 85D, 86A, 87C, 88G, 89V, 90G, 111K, 139K, 140G, 153H, 156L, 241R, 242I, 245I, 246R, 248H, 251Q, 277Q, 279A, 280Y, 281S, 283R, 284C, 287Q, 288V, 294L, 295A, 298Y, 301Q, 302T, 305T, 306E, 309S, 310V, 315L, 316I, 317F, 323A, 325I, 326S, 327G, 328G, 329N, 330F, 331H, 333Q, 334P, 337I, 341T, 348E, 351N, 355R, 359K, 362N, 365L, 378G, 379I, 381D, 382G, 384M, 385I, 386P, 387Q, 389V, 391A, 392A, 393L, 394V, 395S, 396E, 398K, 399V, 400L, 401A, 412S, 413A, 414N, 415Q, 416E, 417D, 418H, 421M, 427R, 428K, 431T, 434D, 435H
CDD
cd00332 (PAL-HAL)

393L

tetramer interface
60G, 61F, 80N, 83Y, 84S, 85D, 86A, 87C, 88G, 89V, 90G, 111K, 139K, 140G, 153H, 156L, 241R, 242I, 245I, 246R, 248H, 251Q, 277Q, 279A, 280Y, 281S, 283R, 284C, 287Q, 288V, 294L, 295A, 298Y, 301Q, 302T, 305T, 306E, 309S, 310V, 315L, 316I, 317F, 323A, 325I, 326S, 327G, 328G, 329N, 330F, 331H, 333Q, 334P, 337I, 341T, 348E, 351N, 355R, 359K, 362N, 365L, 378G, 379I, 381D, 382G, 384M, 385I, 386P, 387Q, 389V, 391A, 392A, 393L, 394V, 395S, 396E, 398K, 399V, 400L, 401A, 412S, 413A, 414N, 415Q, 416E, 417D, 418H, 421M, 427R, 428K, 431T, 434D, 435H
CDD
cd00332 (PAL-HAL)

394V

tetramer interface
60G, 61F, 80N, 83Y, 84S, 85D, 86A, 87C, 88G, 89V, 90G, 111K, 139K, 140G, 153H, 156L, 241R, 242I, 245I, 246R, 248H, 251Q, 277Q, 279A, 280Y, 281S, 283R, 284C, 287Q, 288V, 294L, 295A, 298Y, 301Q, 302T, 305T, 306E, 309S, 310V, 315L, 316I, 317F, 323A, 325I, 326S, 327G, 328G, 329N, 330F, 331H, 333Q, 334P, 337I, 341T, 348E, 351N, 355R, 359K, 362N, 365L, 378G, 379I, 381D, 382G, 384M, 385I, 386P, 387Q, 389V, 391A, 392A, 393L, 394V, 395S, 396E, 398K, 399V, 400L, 401A, 412S, 413A, 414N, 415Q, 416E, 417D, 418H, 421M, 427R, 428K, 431T, 434D, 435H
CDD
cd00332 (PAL-HAL)

395S

tetramer interface
60G, 61F, 80N, 83Y, 84S, 85D, 86A, 87C, 88G, 89V, 90G, 111K, 139K, 140G, 153H, 156L, 241R, 242I, 245I, 246R, 248H, 251Q, 277Q, 279A, 280Y, 281S, 283R, 284C, 287Q, 288V, 294L, 295A, 298Y, 301Q, 302T, 305T, 306E, 309S, 310V, 315L, 316I, 317F, 323A, 325I, 326S, 327G, 328G, 329N, 330F, 331H, 333Q, 334P, 337I, 341T, 348E, 351N, 355R, 359K, 362N, 365L, 378G, 379I, 381D, 382G, 384M, 385I, 386P, 387Q, 389V, 391A, 392A, 393L, 394V, 395S, 396E, 398K, 399V, 400L, 401A, 412S, 413A, 414N, 415Q, 416E, 417D, 418H, 421M, 427R, 428K, 431T, 434D, 435H
CDD
cd00332 (PAL-HAL)

396E

tetramer interface
60G, 61F, 80N, 83Y, 84S, 85D, 86A, 87C, 88G, 89V, 90G, 111K, 139K, 140G, 153H, 156L, 241R, 242I, 245I, 246R, 248H, 251Q, 277Q, 279A, 280Y, 281S, 283R, 284C, 287Q, 288V, 294L, 295A, 298Y, 301Q, 302T, 305T, 306E, 309S, 310V, 315L, 316I, 317F, 323A, 325I, 326S, 327G, 328G, 329N, 330F, 331H, 333Q, 334P, 337I, 341T, 348E, 351N, 355R, 359K, 362N, 365L, 378G, 379I, 381D, 382G, 384M, 385I, 386P, 387Q, 389V, 391A, 392A, 393L, 394V, 395S, 396E, 398K, 399V, 400L, 401A, 412S, 413A, 414N, 415Q, 416E, 417D, 418H, 421M, 427R, 428K, 431T, 434D, 435H
CDD
cd00332 (PAL-HAL)

398K

tetramer interface
60G, 61F, 80N, 83Y, 84S, 85D, 86A, 87C, 88G, 89V, 90G, 111K, 139K, 140G, 153H, 156L, 241R, 242I, 245I, 246R, 248H, 251Q, 277Q, 279A, 280Y, 281S, 283R, 284C, 287Q, 288V, 294L, 295A, 298Y, 301Q, 302T, 305T, 306E, 309S, 310V, 315L, 316I, 317F, 323A, 325I, 326S, 327G, 328G, 329N, 330F, 331H, 333Q, 334P, 337I, 341T, 348E, 351N, 355R, 359K, 362N, 365L, 378G, 379I, 381D, 382G, 384M, 385I, 386P, 387Q, 389V, 391A, 392A, 393L, 394V, 395S, 396E, 398K, 399V, 400L, 401A, 412S, 413A, 414N, 415Q, 416E, 417D, 418H, 421M, 427R, 428K, 431T, 434D, 435H
CDD
cd00332 (PAL-HAL)

399V

tetramer interface
60G, 61F, 80N, 83Y, 84S, 85D, 86A, 87C, 88G, 89V, 90G, 111K, 139K, 140G, 153H, 156L, 241R, 242I, 245I, 246R, 248H, 251Q, 277Q, 279A, 280Y, 281S, 283R, 284C, 287Q, 288V, 294L, 295A, 298Y, 301Q, 302T, 305T, 306E, 309S, 310V, 315L, 316I, 317F, 323A, 325I, 326S, 327G, 328G, 329N, 330F, 331H, 333Q, 334P, 337I, 341T, 348E, 351N, 355R, 359K, 362N, 365L, 378G, 379I, 381D, 382G, 384M, 385I, 386P, 387Q, 389V, 391A, 392A, 393L, 394V, 395S, 396E, 398K, 399V, 400L, 401A, 412S, 413A, 414N, 415Q, 416E, 417D, 418H, 421M, 427R, 428K, 431T, 434D, 435H
CDD
cd00332 (PAL-HAL)

400L

tetramer interface
60G, 61F, 80N, 83Y, 84S, 85D, 86A, 87C, 88G, 89V, 90G, 111K, 139K, 140G, 153H, 156L, 241R, 242I, 245I, 246R, 248H, 251Q, 277Q, 279A, 280Y, 281S, 283R, 284C, 287Q, 288V, 294L, 295A, 298Y, 301Q, 302T, 305T, 306E, 309S, 310V, 315L, 316I, 317F, 323A, 325I, 326S, 327G, 328G, 329N, 330F, 331H, 333Q, 334P, 337I, 341T, 348E, 351N, 355R, 359K, 362N, 365L, 378G, 379I, 381D, 382G, 384M, 385I, 386P, 387Q, 389V, 391A, 392A, 393L, 394V, 395S, 396E, 398K, 399V, 400L, 401A, 412S, 413A, 414N, 415Q, 416E, 417D, 418H, 421M, 427R, 428K, 431T, 434D, 435H
CDD
cd00332 (PAL-HAL)

401A

tetramer interface
60G, 61F, 80N, 83Y, 84S, 85D, 86A, 87C, 88G, 89V, 90G, 111K, 139K, 140G, 153H, 156L, 241R, 242I, 245I, 246R, 248H, 251Q, 277Q, 279A, 280Y, 281S, 283R, 284C, 287Q, 288V, 294L, 295A, 298Y, 301Q, 302T, 305T, 306E, 309S, 310V, 315L, 316I, 317F, 323A, 325I, 326S, 327G, 328G, 329N, 330F, 331H, 333Q, 334P, 337I, 341T, 348E, 351N, 355R, 359K, 362N, 365L, 378G, 379I, 381D, 382G, 384M, 385I, 386P, 387Q, 389V, 391A, 392A, 393L, 394V, 395S, 396E, 398K, 399V, 400L, 401A, 412S, 413A, 414N, 415Q, 416E, 417D, 418H, 421M, 427R, 428K, 431T, 434D, 435H
CDD
cd00332 (PAL-HAL)

412S

tetramer interface
60G, 61F, 80N, 83Y, 84S, 85D, 86A, 87C, 88G, 89V, 90G, 111K, 139K, 140G, 153H, 156L, 241R, 242I, 245I, 246R, 248H, 251Q, 277Q, 279A, 280Y, 281S, 283R, 284C, 287Q, 288V, 294L, 295A, 298Y, 301Q, 302T, 305T, 306E, 309S, 310V, 315L, 316I, 317F, 323A, 325I, 326S, 327G, 328G, 329N, 330F, 331H, 333Q, 334P, 337I, 341T, 348E, 351N, 355R, 359K, 362N, 365L, 378G, 379I, 381D, 382G, 384M, 385I, 386P, 387Q, 389V, 391A, 392A, 393L, 394V, 395S, 396E, 398K, 399V, 400L, 401A, 412S, 413A, 414N, 415Q, 416E, 417D, 418H, 421M, 427R, 428K, 431T, 434D, 435H
CDD
cd00332 (PAL-HAL)

413A

tetramer interface
60G, 61F, 80N, 83Y, 84S, 85D, 86A, 87C, 88G, 89V, 90G, 111K, 139K, 140G, 153H, 156L, 241R, 242I, 245I, 246R, 248H, 251Q, 277Q, 279A, 280Y, 281S, 283R, 284C, 287Q, 288V, 294L, 295A, 298Y, 301Q, 302T, 305T, 306E, 309S, 310V, 315L, 316I, 317F, 323A, 325I, 326S, 327G, 328G, 329N, 330F, 331H, 333Q, 334P, 337I, 341T, 348E, 351N, 355R, 359K, 362N, 365L, 378G, 379I, 381D, 382G, 384M, 385I, 386P, 387Q, 389V, 391A, 392A, 393L, 394V, 395S, 396E, 398K, 399V, 400L, 401A, 412S, 413A, 414N, 415Q, 416E, 417D, 418H, 421M, 427R, 428K, 431T, 434D, 435H
CDD
cd00332 (PAL-HAL)

414N

tetramer interface
60G, 61F, 80N, 83Y, 84S, 85D, 86A, 87C, 88G, 89V, 90G, 111K, 139K, 140G, 153H, 156L, 241R, 242I, 245I, 246R, 248H, 251Q, 277Q, 279A, 280Y, 281S, 283R, 284C, 287Q, 288V, 294L, 295A, 298Y, 301Q, 302T, 305T, 306E, 309S, 310V, 315L, 316I, 317F, 323A, 325I, 326S, 327G, 328G, 329N, 330F, 331H, 333Q, 334P, 337I, 341T, 348E, 351N, 355R, 359K, 362N, 365L, 378G, 379I, 381D, 382G, 384M, 385I, 386P, 387Q, 389V, 391A, 392A, 393L, 394V, 395S, 396E, 398K, 399V, 400L, 401A, 412S, 413A, 414N, 415Q, 416E, 417D, 418H, 421M, 427R, 428K, 431T, 434D, 435H
CDD
cd00332 (PAL-HAL)

415Q

tetramer interface
60G, 61F, 80N, 83Y, 84S, 85D, 86A, 87C, 88G, 89V, 90G, 111K, 139K, 140G, 153H, 156L, 241R, 242I, 245I, 246R, 248H, 251Q, 277Q, 279A, 280Y, 281S, 283R, 284C, 287Q, 288V, 294L, 295A, 298Y, 301Q, 302T, 305T, 306E, 309S, 310V, 315L, 316I, 317F, 323A, 325I, 326S, 327G, 328G, 329N, 330F, 331H, 333Q, 334P, 337I, 341T, 348E, 351N, 355R, 359K, 362N, 365L, 378G, 379I, 381D, 382G, 384M, 385I, 386P, 387Q, 389V, 391A, 392A, 393L, 394V, 395S, 396E, 398K, 399V, 400L, 401A, 412S, 413A, 414N, 415Q, 416E, 417D, 418H, 421M, 427R, 428K, 431T, 434D, 435H
CDD
cd00332 (PAL-HAL)

416E

tetramer interface
60G, 61F, 80N, 83Y, 84S, 85D, 86A, 87C, 88G, 89V, 90G, 111K, 139K, 140G, 153H, 156L, 241R, 242I, 245I, 246R, 248H, 251Q, 277Q, 279A, 280Y, 281S, 283R, 284C, 287Q, 288V, 294L, 295A, 298Y, 301Q, 302T, 305T, 306E, 309S, 310V, 315L, 316I, 317F, 323A, 325I, 326S, 327G, 328G, 329N, 330F, 331H, 333Q, 334P, 337I, 341T, 348E, 351N, 355R, 359K, 362N, 365L, 378G, 379I, 381D, 382G, 384M, 385I, 386P, 387Q, 389V, 391A, 392A, 393L, 394V, 395S, 396E, 398K, 399V, 400L, 401A, 412S, 413A, 414N, 415Q, 416E, 417D, 418H, 421M, 427R, 428K, 431T, 434D, 435H
CDD
cd00332 (PAL-HAL)

417D

tetramer interface
60G, 61F, 80N, 83Y, 84S, 85D, 86A, 87C, 88G, 89V, 90G, 111K, 139K, 140G, 153H, 156L, 241R, 242I, 245I, 246R, 248H, 251Q, 277Q, 279A, 280Y, 281S, 283R, 284C, 287Q, 288V, 294L, 295A, 298Y, 301Q, 302T, 305T, 306E, 309S, 310V, 315L, 316I, 317F, 323A, 325I, 326S, 327G, 328G, 329N, 330F, 331H, 333Q, 334P, 337I, 341T, 348E, 351N, 355R, 359K, 362N, 365L, 378G, 379I, 381D, 382G, 384M, 385I, 386P, 387Q, 389V, 391A, 392A, 393L, 394V, 395S, 396E, 398K, 399V, 400L, 401A, 412S, 413A, 414N, 415Q, 416E, 417D, 418H, 421M, 427R, 428K, 431T, 434D, 435H
CDD
cd00332 (PAL-HAL)

418H

tetramer interface
60G, 61F, 80N, 83Y, 84S, 85D, 86A, 87C, 88G, 89V, 90G, 111K, 139K, 140G, 153H, 156L, 241R, 242I, 245I, 246R, 248H, 251Q, 277Q, 279A, 280Y, 281S, 283R, 284C, 287Q, 288V, 294L, 295A, 298Y, 301Q, 302T, 305T, 306E, 309S, 310V, 315L, 316I, 317F, 323A, 325I, 326S, 327G, 328G, 329N, 330F, 331H, 333Q, 334P, 337I, 341T, 348E, 351N, 355R, 359K, 362N, 365L, 378G, 379I, 381D, 382G, 384M, 385I, 386P, 387Q, 389V, 391A, 392A, 393L, 394V, 395S, 396E, 398K, 399V, 400L, 401A, 412S, 413A, 414N, 415Q, 416E, 417D, 418H, 421M, 427R, 428K, 431T, 434D, 435H
CDD
cd00332 (PAL-HAL)

421M

tetramer interface
60G, 61F, 80N, 83Y, 84S, 85D, 86A, 87C, 88G, 89V, 90G, 111K, 139K, 140G, 153H, 156L, 241R, 242I, 245I, 246R, 248H, 251Q, 277Q, 279A, 280Y, 281S, 283R, 284C, 287Q, 288V, 294L, 295A, 298Y, 301Q, 302T, 305T, 306E, 309S, 310V, 315L, 316I, 317F, 323A, 325I, 326S, 327G, 328G, 329N, 330F, 331H, 333Q, 334P, 337I, 341T, 348E, 351N, 355R, 359K, 362N, 365L, 378G, 379I, 381D, 382G, 384M, 385I, 386P, 387Q, 389V, 391A, 392A, 393L, 394V, 395S, 396E, 398K, 399V, 400L, 401A, 412S, 413A, 414N, 415Q, 416E, 417D, 418H, 421M, 427R, 428K, 431T, 434D, 435H
CDD
cd00332 (PAL-HAL)

427R

tetramer interface
60G, 61F, 80N, 83Y, 84S, 85D, 86A, 87C, 88G, 89V, 90G, 111K, 139K, 140G, 153H, 156L, 241R, 242I, 245I, 246R, 248H, 251Q, 277Q, 279A, 280Y, 281S, 283R, 284C, 287Q, 288V, 294L, 295A, 298Y, 301Q, 302T, 305T, 306E, 309S, 310V, 315L, 316I, 317F, 323A, 325I, 326S, 327G, 328G, 329N, 330F, 331H, 333Q, 334P, 337I, 341T, 348E, 351N, 355R, 359K, 362N, 365L, 378G, 379I, 381D, 382G, 384M, 385I, 386P, 387Q, 389V, 391A, 392A, 393L, 394V, 395S, 396E, 398K, 399V, 400L, 401A, 412S, 413A, 414N, 415Q, 416E, 417D, 418H, 421M, 427R, 428K, 431T, 434D, 435H
CDD
cd00332 (PAL-HAL)

428K

tetramer interface
60G, 61F, 80N, 83Y, 84S, 85D, 86A, 87C, 88G, 89V, 90G, 111K, 139K, 140G, 153H, 156L, 241R, 242I, 245I, 246R, 248H, 251Q, 277Q, 279A, 280Y, 281S, 283R, 284C, 287Q, 288V, 294L, 295A, 298Y, 301Q, 302T, 305T, 306E, 309S, 310V, 315L, 316I, 317F, 323A, 325I, 326S, 327G, 328G, 329N, 330F, 331H, 333Q, 334P, 337I, 341T, 348E, 351N, 355R, 359K, 362N, 365L, 378G, 379I, 381D, 382G, 384M, 385I, 386P, 387Q, 389V, 391A, 392A, 393L, 394V, 395S, 396E, 398K, 399V, 400L, 401A, 412S, 413A, 414N, 415Q, 416E, 417D, 418H, 421M, 427R, 428K, 431T, 434D, 435H
CDD
cd00332 (PAL-HAL)

431T

tetramer interface
60G, 61F, 80N, 83Y, 84S, 85D, 86A, 87C, 88G, 89V, 90G, 111K, 139K, 140G, 153H, 156L, 241R, 242I, 245I, 246R, 248H, 251Q, 277Q, 279A, 280Y, 281S, 283R, 284C, 287Q, 288V, 294L, 295A, 298Y, 301Q, 302T, 305T, 306E, 309S, 310V, 315L, 316I, 317F, 323A, 325I, 326S, 327G, 328G, 329N, 330F, 331H, 333Q, 334P, 337I, 341T, 348E, 351N, 355R, 359K, 362N, 365L, 378G, 379I, 381D, 382G, 384M, 385I, 386P, 387Q, 389V, 391A, 392A, 393L, 394V, 395S, 396E, 398K, 399V, 400L, 401A, 412S, 413A, 414N, 415Q, 416E, 417D, 418H, 421M, 427R, 428K, 431T, 434D, 435H
CDD
cd00332 (PAL-HAL)

434D

tetramer interface
60G, 61F, 80N, 83Y, 84S, 85D, 86A, 87C, 88G, 89V, 90G, 111K, 139K, 140G, 153H, 156L, 241R, 242I, 245I, 246R, 248H, 251Q, 277Q, 279A, 280Y, 281S, 283R, 284C, 287Q, 288V, 294L, 295A, 298Y, 301Q, 302T, 305T, 306E, 309S, 310V, 315L, 316I, 317F, 323A, 325I, 326S, 327G, 328G, 329N, 330F, 331H, 333Q, 334P, 337I, 341T, 348E, 351N, 355R, 359K, 362N, 365L, 378G, 379I, 381D, 382G, 384M, 385I, 386P, 387Q, 389V, 391A, 392A, 393L, 394V, 395S, 396E, 398K, 399V, 400L, 401A, 412S, 413A, 414N, 415Q, 416E, 417D, 418H, 421M, 427R, 428K, 431T, 434D, 435H
CDD
cd00332 (PAL-HAL)

435H

tetramer interface
60G, 61F, 80N, 83Y, 84S, 85D, 86A, 87C, 88G, 89V, 90G, 111K, 139K, 140G, 153H, 156L, 241R, 242I, 245I, 246R, 248H, 251Q, 277Q, 279A, 280Y, 281S, 283R, 284C, 287Q, 288V, 294L, 295A, 298Y, 301Q, 302T, 305T, 306E, 309S, 310V, 315L, 316I, 317F, 323A, 325I, 326S, 327G, 328G, 329N, 330F, 331H, 333Q, 334P, 337I, 341T, 348E, 351N, 355R, 359K, 362N, 365L, 378G, 379I, 381D, 382G, 384M, 385I, 386P, 387Q, 389V, 391A, 392A, 393L, 394V, 395S, 396E, 398K, 399V, 400L, 401A, 412S, 413A, 414N, 415Q, 416E, 417D, 418H, 421M, 427R, 428K, 431T, 434D, 435H
CDD
cd00332 (PAL-HAL)

GO term prediction

Biological Process

GO:0006548 histidine catabolic process

Molecular Function

GO:0003824 catalytic activity
GO:0004397 histidine ammonia-lyase activity
GO:0016841 ammonia-lyase activity

Cellular Component

GO:0005737 cytoplasm

Filter view on

Entry type

Status

Per-residue features

25586_FusoPortal_Gene_1935

Protein family membership

Homologous superfamilies

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component