25586_FusoPortal_Gene_243

Protein

25586_FusoPortal_Gene_243

Length

280 amino acids

Protein family membership

None predicted.

Homologous superfamilies

Homologous superfamily
1 - 276
Ribokinase-like (IPR029056)

1 50 100 150 200 250 280

Domains and repeats

Domain
6 - 266
Pyridoxamine kinase/Phosphomethylpyrimidine kinase (IPR013749)
Hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase (IPR004399)

1 50 100 150 200 250 280

Detailed signature matches

IPR029056

Ribokinase-like
1. G3DSA:3.40.11...
  
  1 - 256
  
  GENE3D
  G3DSA:3.40.1190.20 (G3DSA:3.40.1190.20)
2. SSF53613 (Ribokinas...)
  
  3 - 276
  
  SUPERFAMILY
  SSF53613 (Ribokinase-like)
IPR013749

Pyridoxamine kinase/Phosphomethylpyrimidine kinase
1. PF08543 (Phos_pyr_kin)
  
  14 - 265
  
  Pfam
  PF08543 (Phos_pyr_kin)
IPR004399

Hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase
1. cd01169 (HMPP_kinase)
  
  6 - 254
  
  CDD
  cd01169 (HMPP_kinase)
2. TIGR00097
  
  7 - 266
  
  TIGRFAMs
  TIGR00097 (TIGR00097)

no IPR

Unintegrated signatures

PTHR20858 (PHOSPHOM...)

1 - 275

PANTHER
PTHR20858 (PHOSPHOMETHYLPYRIMIDINE KINASE)
PTHR20858:SF17 (HYD...)

1 - 275

PANTHER
PTHR20858:SF17 (HYDROXYMETHYLPYRIMIDINE/PHOSPHOMETHYLPYRIMIDINE KINASE THI20-RELATED)

Residue annotation

dimer interface cd...

6N

dimer interface
6N, 13S, 15C, 16S, 18G, 22Q, 25L, 26K, 29V, 32G, 33V, 34Y, 35G, 36M, 37T, 39I, 42L, 43T, 44A, 45Q, 46N, 51K, 52M, 54E, 56V, 57S, 60M, 63K, 67A, 68I
CDD
cd01169 (HMPP_kinase)

13S

dimer interface
6N, 13S, 15C, 16S, 18G, 22Q, 25L, 26K, 29V, 32G, 33V, 34Y, 35G, 36M, 37T, 39I, 42L, 43T, 44A, 45Q, 46N, 51K, 52M, 54E, 56V, 57S, 60M, 63K, 67A, 68I
CDD
cd01169 (HMPP_kinase)

15C

dimer interface
6N, 13S, 15C, 16S, 18G, 22Q, 25L, 26K, 29V, 32G, 33V, 34Y, 35G, 36M, 37T, 39I, 42L, 43T, 44A, 45Q, 46N, 51K, 52M, 54E, 56V, 57S, 60M, 63K, 67A, 68I
CDD
cd01169 (HMPP_kinase)

16S

dimer interface
6N, 13S, 15C, 16S, 18G, 22Q, 25L, 26K, 29V, 32G, 33V, 34Y, 35G, 36M, 37T, 39I, 42L, 43T, 44A, 45Q, 46N, 51K, 52M, 54E, 56V, 57S, 60M, 63K, 67A, 68I
CDD
cd01169 (HMPP_kinase)

18G

dimer interface
6N, 13S, 15C, 16S, 18G, 22Q, 25L, 26K, 29V, 32G, 33V, 34Y, 35G, 36M, 37T, 39I, 42L, 43T, 44A, 45Q, 46N, 51K, 52M, 54E, 56V, 57S, 60M, 63K, 67A, 68I
CDD
cd01169 (HMPP_kinase)

22Q

dimer interface
6N, 13S, 15C, 16S, 18G, 22Q, 25L, 26K, 29V, 32G, 33V, 34Y, 35G, 36M, 37T, 39I, 42L, 43T, 44A, 45Q, 46N, 51K, 52M, 54E, 56V, 57S, 60M, 63K, 67A, 68I
CDD
cd01169 (HMPP_kinase)

25L

dimer interface
6N, 13S, 15C, 16S, 18G, 22Q, 25L, 26K, 29V, 32G, 33V, 34Y, 35G, 36M, 37T, 39I, 42L, 43T, 44A, 45Q, 46N, 51K, 52M, 54E, 56V, 57S, 60M, 63K, 67A, 68I
CDD
cd01169 (HMPP_kinase)

26K

dimer interface
6N, 13S, 15C, 16S, 18G, 22Q, 25L, 26K, 29V, 32G, 33V, 34Y, 35G, 36M, 37T, 39I, 42L, 43T, 44A, 45Q, 46N, 51K, 52M, 54E, 56V, 57S, 60M, 63K, 67A, 68I
CDD
cd01169 (HMPP_kinase)

29V

dimer interface
6N, 13S, 15C, 16S, 18G, 22Q, 25L, 26K, 29V, 32G, 33V, 34Y, 35G, 36M, 37T, 39I, 42L, 43T, 44A, 45Q, 46N, 51K, 52M, 54E, 56V, 57S, 60M, 63K, 67A, 68I
CDD
cd01169 (HMPP_kinase)

32G

dimer interface
6N, 13S, 15C, 16S, 18G, 22Q, 25L, 26K, 29V, 32G, 33V, 34Y, 35G, 36M, 37T, 39I, 42L, 43T, 44A, 45Q, 46N, 51K, 52M, 54E, 56V, 57S, 60M, 63K, 67A, 68I
CDD
cd01169 (HMPP_kinase)

33V

dimer interface
6N, 13S, 15C, 16S, 18G, 22Q, 25L, 26K, 29V, 32G, 33V, 34Y, 35G, 36M, 37T, 39I, 42L, 43T, 44A, 45Q, 46N, 51K, 52M, 54E, 56V, 57S, 60M, 63K, 67A, 68I
CDD
cd01169 (HMPP_kinase)

34Y

dimer interface
6N, 13S, 15C, 16S, 18G, 22Q, 25L, 26K, 29V, 32G, 33V, 34Y, 35G, 36M, 37T, 39I, 42L, 43T, 44A, 45Q, 46N, 51K, 52M, 54E, 56V, 57S, 60M, 63K, 67A, 68I
CDD
cd01169 (HMPP_kinase)

35G

dimer interface
6N, 13S, 15C, 16S, 18G, 22Q, 25L, 26K, 29V, 32G, 33V, 34Y, 35G, 36M, 37T, 39I, 42L, 43T, 44A, 45Q, 46N, 51K, 52M, 54E, 56V, 57S, 60M, 63K, 67A, 68I
CDD
cd01169 (HMPP_kinase)

36M

dimer interface
6N, 13S, 15C, 16S, 18G, 22Q, 25L, 26K, 29V, 32G, 33V, 34Y, 35G, 36M, 37T, 39I, 42L, 43T, 44A, 45Q, 46N, 51K, 52M, 54E, 56V, 57S, 60M, 63K, 67A, 68I
CDD
cd01169 (HMPP_kinase)

37T

dimer interface
6N, 13S, 15C, 16S, 18G, 22Q, 25L, 26K, 29V, 32G, 33V, 34Y, 35G, 36M, 37T, 39I, 42L, 43T, 44A, 45Q, 46N, 51K, 52M, 54E, 56V, 57S, 60M, 63K, 67A, 68I
CDD
cd01169 (HMPP_kinase)

39I

dimer interface
6N, 13S, 15C, 16S, 18G, 22Q, 25L, 26K, 29V, 32G, 33V, 34Y, 35G, 36M, 37T, 39I, 42L, 43T, 44A, 45Q, 46N, 51K, 52M, 54E, 56V, 57S, 60M, 63K, 67A, 68I
CDD
cd01169 (HMPP_kinase)

42L

dimer interface
6N, 13S, 15C, 16S, 18G, 22Q, 25L, 26K, 29V, 32G, 33V, 34Y, 35G, 36M, 37T, 39I, 42L, 43T, 44A, 45Q, 46N, 51K, 52M, 54E, 56V, 57S, 60M, 63K, 67A, 68I
CDD
cd01169 (HMPP_kinase)

43T

dimer interface
6N, 13S, 15C, 16S, 18G, 22Q, 25L, 26K, 29V, 32G, 33V, 34Y, 35G, 36M, 37T, 39I, 42L, 43T, 44A, 45Q, 46N, 51K, 52M, 54E, 56V, 57S, 60M, 63K, 67A, 68I
CDD
cd01169 (HMPP_kinase)

44A

dimer interface
6N, 13S, 15C, 16S, 18G, 22Q, 25L, 26K, 29V, 32G, 33V, 34Y, 35G, 36M, 37T, 39I, 42L, 43T, 44A, 45Q, 46N, 51K, 52M, 54E, 56V, 57S, 60M, 63K, 67A, 68I
CDD
cd01169 (HMPP_kinase)

45Q

dimer interface
6N, 13S, 15C, 16S, 18G, 22Q, 25L, 26K, 29V, 32G, 33V, 34Y, 35G, 36M, 37T, 39I, 42L, 43T, 44A, 45Q, 46N, 51K, 52M, 54E, 56V, 57S, 60M, 63K, 67A, 68I
CDD
cd01169 (HMPP_kinase)

46N

dimer interface
6N, 13S, 15C, 16S, 18G, 22Q, 25L, 26K, 29V, 32G, 33V, 34Y, 35G, 36M, 37T, 39I, 42L, 43T, 44A, 45Q, 46N, 51K, 52M, 54E, 56V, 57S, 60M, 63K, 67A, 68I
CDD
cd01169 (HMPP_kinase)

51K

dimer interface
6N, 13S, 15C, 16S, 18G, 22Q, 25L, 26K, 29V, 32G, 33V, 34Y, 35G, 36M, 37T, 39I, 42L, 43T, 44A, 45Q, 46N, 51K, 52M, 54E, 56V, 57S, 60M, 63K, 67A, 68I
CDD
cd01169 (HMPP_kinase)

52M

dimer interface
6N, 13S, 15C, 16S, 18G, 22Q, 25L, 26K, 29V, 32G, 33V, 34Y, 35G, 36M, 37T, 39I, 42L, 43T, 44A, 45Q, 46N, 51K, 52M, 54E, 56V, 57S, 60M, 63K, 67A, 68I
CDD
cd01169 (HMPP_kinase)

54E

dimer interface
6N, 13S, 15C, 16S, 18G, 22Q, 25L, 26K, 29V, 32G, 33V, 34Y, 35G, 36M, 37T, 39I, 42L, 43T, 44A, 45Q, 46N, 51K, 52M, 54E, 56V, 57S, 60M, 63K, 67A, 68I
CDD
cd01169 (HMPP_kinase)

56V

dimer interface
6N, 13S, 15C, 16S, 18G, 22Q, 25L, 26K, 29V, 32G, 33V, 34Y, 35G, 36M, 37T, 39I, 42L, 43T, 44A, 45Q, 46N, 51K, 52M, 54E, 56V, 57S, 60M, 63K, 67A, 68I
CDD
cd01169 (HMPP_kinase)

57S

dimer interface
6N, 13S, 15C, 16S, 18G, 22Q, 25L, 26K, 29V, 32G, 33V, 34Y, 35G, 36M, 37T, 39I, 42L, 43T, 44A, 45Q, 46N, 51K, 52M, 54E, 56V, 57S, 60M, 63K, 67A, 68I
CDD
cd01169 (HMPP_kinase)

60M

dimer interface
6N, 13S, 15C, 16S, 18G, 22Q, 25L, 26K, 29V, 32G, 33V, 34Y, 35G, 36M, 37T, 39I, 42L, 43T, 44A, 45Q, 46N, 51K, 52M, 54E, 56V, 57S, 60M, 63K, 67A, 68I
CDD
cd01169 (HMPP_kinase)

63K

dimer interface
6N, 13S, 15C, 16S, 18G, 22Q, 25L, 26K, 29V, 32G, 33V, 34Y, 35G, 36M, 37T, 39I, 42L, 43T, 44A, 45Q, 46N, 51K, 52M, 54E, 56V, 57S, 60M, 63K, 67A, 68I
CDD
cd01169 (HMPP_kinase)

67A

dimer interface
6N, 13S, 15C, 16S, 18G, 22Q, 25L, 26K, 29V, 32G, 33V, 34Y, 35G, 36M, 37T, 39I, 42L, 43T, 44A, 45Q, 46N, 51K, 52M, 54E, 56V, 57S, 60M, 63K, 67A, 68I
CDD
cd01169 (HMPP_kinase)

68I

dimer interface
6N, 13S, 15C, 16S, 18G, 22Q, 25L, 26K, 29V, 32G, 33V, 34Y, 35G, 36M, 37T, 39I, 42L, 43T, 44A, 45Q, 46N, 51K, 52M, 54E, 56V, 57S, 60M, 63K, 67A, 68I
CDD
cd01169 (HMPP_kinase)
substrate binding ...

12G

substrate binding site
12G, 24D, 45Q, 81M, 220C
CDD
cd01169 (HMPP_kinase)

24D

substrate binding site
12G, 24D, 45Q, 81M, 220C
CDD
cd01169 (HMPP_kinase)

45Q

substrate binding site
12G, 24D, 45Q, 81M, 220C
CDD
cd01169 (HMPP_kinase)

81M

substrate binding site
12G, 24D, 45Q, 81M, 220C
CDD
cd01169 (HMPP_kinase)

220C

substrate binding site
12G, 24D, 45Q, 81M, 220C
CDD
cd01169 (HMPP_kinase)
ATP binding site c...

106D

ATP binding site
106D, 143E, 184K, 217G, 219G
CDD
cd01169 (HMPP_kinase)

143E

ATP binding site
106D, 143E, 184K, 217G, 219G
CDD
cd01169 (HMPP_kinase)

184K

ATP binding site
106D, 143E, 184K, 217G, 219G
CDD
cd01169 (HMPP_kinase)

217G

ATP binding site
106D, 143E, 184K, 217G, 219G
CDD
cd01169 (HMPP_kinase)

219G

ATP binding site
106D, 143E, 184K, 217G, 219G
CDD
cd01169 (HMPP_kinase)

GO term prediction

Biological Process

GO:0009228 thiamine biosynthetic process

Molecular Function

GO:0008972 phosphomethylpyrimidine kinase activity

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features

25586_FusoPortal_Gene_243

Protein family membership

Homologous superfamilies

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component