25586_FusoPortal_Gene_358

Protein

25586_FusoPortal_Gene_358

Length

253 amino acids

Protein family membership

AP endonuclease 1 (IPR004808)

Homologous superfamilies

Homologous superfamily
1 - 253
Endonuclease/exonuclease/phosphatase superfamily (IPR036691)

1 50 100 150 200 253

Domains and repeats

Domain
5 - 242
Endonuclease/exonuclease/phosphatase (IPR005135)

1 50 100 150 200 253

Detailed signature matches

IPR036691

Endonuclease/exonuclease/phosphatase superfamily
1. SSF56219 (DNase I-like)
  
  1 - 250
  
  SUPERFAMILY
  SSF56219 (DNase I-like)
2. G3DSA:3.60.10.10
  
  1 - 253
  
  GENE3D
  G3DSA:3.60.10.10 (G3DSA:3.60.10.10)
IPR004808

AP endonuclease 1
1. PS51435 (AP_NUCLEAS...)
  
  1 - 251
  
  PROSITE profiles
  PS51435 (AP_NUCLEASE_F1_4)
2. TIGR00633
  
  1 - 249
  
  TIGRFAMs
  TIGR00633 (TIGR00633)
3. PTHR22748 (AP ENDON...)
  
  1 - 250
  
  PANTHER
  PTHR22748 (AP ENDONUCLEASE)
IPR005135

Endonuclease/exonuclease/phosphatase
1. PF03372 (Exo_endo_phos)
  
  5 - 242
  
  Pfam
  PF03372 (Exo_endo_phos)
IPR020847

AP endonuclease 1, binding site
1. PS00726 (AP_NUCLEAS...)
  
  28 - 37
  
  PROSITE patterns
  PS00726 (AP_NUCLEASE_F1_1)
IPR020848

AP endonuclease 1, conserved site
1. PS00728 (AP_NUCLEAS...)
  
  210 - 221
  
  PROSITE patterns
  PS00728 (AP_NUCLEASE_F1_3)

no IPR

Unintegrated signatures

PTHR22748:SF6 (DNA-...)

1 - 250

PANTHER
PTHR22748:SF6 (DNA- APURINIC OR APYRIMIDINIC SITE LYASE)
TIGR00195

1 - 248

TIGRFAMs
TIGR00195 (TIGR00195)
cd09087 (Ape1-like_...)

1 - 249

CDD
cd09087 (Ape1-like_AP-endo)

Residue annotation

putative phosphate...

7N

putative phosphate binding site
7N, 35E, 105Y, 108N, 144D, 146N, 242H
CDD
cd09087 (Ape1-like_AP-endo)

35E

putative phosphate binding site
7N, 35E, 105Y, 108N, 144D, 146N, 242H
CDD
cd09087 (Ape1-like_AP-endo)

105Y

putative phosphate binding site
7N, 35E, 105Y, 108N, 144D, 146N, 242H
CDD
cd09087 (Ape1-like_AP-endo)

108N

putative phosphate binding site
7N, 35E, 105Y, 108N, 144D, 146N, 242H
CDD
cd09087 (Ape1-like_AP-endo)

144D

putative phosphate binding site
7N, 35E, 105Y, 108N, 144D, 146N, 242H
CDD
cd09087 (Ape1-like_AP-endo)

146N

putative phosphate binding site
7N, 35E, 105Y, 108N, 144D, 146N, 242H
CDD
cd09087 (Ape1-like_AP-endo)

242H

putative phosphate binding site
7N, 35E, 105Y, 108N, 144D, 146N, 242H
CDD
cd09087 (Ape1-like_AP-endo)
DNA binding site c...

7N

DNA binding site
7N, 9N, 10G, 11I, 12R, 13A, 17K, 35E, 37K, 42Q, 61G, 62Y, 105Y, 108N, 144D, 146N, 156N, 158K, 160N, 163N, 164A, 199W, 201S, 202Y, 203R, 209N, 211A, 213W, 215I, 242H
CDD
cd09087 (Ape1-like_AP-endo)

9N

DNA binding site
7N, 9N, 10G, 11I, 12R, 13A, 17K, 35E, 37K, 42Q, 61G, 62Y, 105Y, 108N, 144D, 146N, 156N, 158K, 160N, 163N, 164A, 199W, 201S, 202Y, 203R, 209N, 211A, 213W, 215I, 242H
CDD
cd09087 (Ape1-like_AP-endo)

10G

DNA binding site
7N, 9N, 10G, 11I, 12R, 13A, 17K, 35E, 37K, 42Q, 61G, 62Y, 105Y, 108N, 144D, 146N, 156N, 158K, 160N, 163N, 164A, 199W, 201S, 202Y, 203R, 209N, 211A, 213W, 215I, 242H
CDD
cd09087 (Ape1-like_AP-endo)

11I

DNA binding site
7N, 9N, 10G, 11I, 12R, 13A, 17K, 35E, 37K, 42Q, 61G, 62Y, 105Y, 108N, 144D, 146N, 156N, 158K, 160N, 163N, 164A, 199W, 201S, 202Y, 203R, 209N, 211A, 213W, 215I, 242H
CDD
cd09087 (Ape1-like_AP-endo)

12R

DNA binding site
7N, 9N, 10G, 11I, 12R, 13A, 17K, 35E, 37K, 42Q, 61G, 62Y, 105Y, 108N, 144D, 146N, 156N, 158K, 160N, 163N, 164A, 199W, 201S, 202Y, 203R, 209N, 211A, 213W, 215I, 242H
CDD
cd09087 (Ape1-like_AP-endo)

13A

DNA binding site
7N, 9N, 10G, 11I, 12R, 13A, 17K, 35E, 37K, 42Q, 61G, 62Y, 105Y, 108N, 144D, 146N, 156N, 158K, 160N, 163N, 164A, 199W, 201S, 202Y, 203R, 209N, 211A, 213W, 215I, 242H
CDD
cd09087 (Ape1-like_AP-endo)

17K

DNA binding site
7N, 9N, 10G, 11I, 12R, 13A, 17K, 35E, 37K, 42Q, 61G, 62Y, 105Y, 108N, 144D, 146N, 156N, 158K, 160N, 163N, 164A, 199W, 201S, 202Y, 203R, 209N, 211A, 213W, 215I, 242H
CDD
cd09087 (Ape1-like_AP-endo)

35E

DNA binding site
7N, 9N, 10G, 11I, 12R, 13A, 17K, 35E, 37K, 42Q, 61G, 62Y, 105Y, 108N, 144D, 146N, 156N, 158K, 160N, 163N, 164A, 199W, 201S, 202Y, 203R, 209N, 211A, 213W, 215I, 242H
CDD
cd09087 (Ape1-like_AP-endo)

37K

DNA binding site
7N, 9N, 10G, 11I, 12R, 13A, 17K, 35E, 37K, 42Q, 61G, 62Y, 105Y, 108N, 144D, 146N, 156N, 158K, 160N, 163N, 164A, 199W, 201S, 202Y, 203R, 209N, 211A, 213W, 215I, 242H
CDD
cd09087 (Ape1-like_AP-endo)

42Q

DNA binding site
7N, 9N, 10G, 11I, 12R, 13A, 17K, 35E, 37K, 42Q, 61G, 62Y, 105Y, 108N, 144D, 146N, 156N, 158K, 160N, 163N, 164A, 199W, 201S, 202Y, 203R, 209N, 211A, 213W, 215I, 242H
CDD
cd09087 (Ape1-like_AP-endo)

61G

DNA binding site
7N, 9N, 10G, 11I, 12R, 13A, 17K, 35E, 37K, 42Q, 61G, 62Y, 105Y, 108N, 144D, 146N, 156N, 158K, 160N, 163N, 164A, 199W, 201S, 202Y, 203R, 209N, 211A, 213W, 215I, 242H
CDD
cd09087 (Ape1-like_AP-endo)

62Y

DNA binding site
7N, 9N, 10G, 11I, 12R, 13A, 17K, 35E, 37K, 42Q, 61G, 62Y, 105Y, 108N, 144D, 146N, 156N, 158K, 160N, 163N, 164A, 199W, 201S, 202Y, 203R, 209N, 211A, 213W, 215I, 242H
CDD
cd09087 (Ape1-like_AP-endo)

105Y

DNA binding site
7N, 9N, 10G, 11I, 12R, 13A, 17K, 35E, 37K, 42Q, 61G, 62Y, 105Y, 108N, 144D, 146N, 156N, 158K, 160N, 163N, 164A, 199W, 201S, 202Y, 203R, 209N, 211A, 213W, 215I, 242H
CDD
cd09087 (Ape1-like_AP-endo)

108N

DNA binding site
7N, 9N, 10G, 11I, 12R, 13A, 17K, 35E, 37K, 42Q, 61G, 62Y, 105Y, 108N, 144D, 146N, 156N, 158K, 160N, 163N, 164A, 199W, 201S, 202Y, 203R, 209N, 211A, 213W, 215I, 242H
CDD
cd09087 (Ape1-like_AP-endo)

144D

DNA binding site
7N, 9N, 10G, 11I, 12R, 13A, 17K, 35E, 37K, 42Q, 61G, 62Y, 105Y, 108N, 144D, 146N, 156N, 158K, 160N, 163N, 164A, 199W, 201S, 202Y, 203R, 209N, 211A, 213W, 215I, 242H
CDD
cd09087 (Ape1-like_AP-endo)

146N

DNA binding site
7N, 9N, 10G, 11I, 12R, 13A, 17K, 35E, 37K, 42Q, 61G, 62Y, 105Y, 108N, 144D, 146N, 156N, 158K, 160N, 163N, 164A, 199W, 201S, 202Y, 203R, 209N, 211A, 213W, 215I, 242H
CDD
cd09087 (Ape1-like_AP-endo)

156N

DNA binding site
7N, 9N, 10G, 11I, 12R, 13A, 17K, 35E, 37K, 42Q, 61G, 62Y, 105Y, 108N, 144D, 146N, 156N, 158K, 160N, 163N, 164A, 199W, 201S, 202Y, 203R, 209N, 211A, 213W, 215I, 242H
CDD
cd09087 (Ape1-like_AP-endo)

158K

DNA binding site
7N, 9N, 10G, 11I, 12R, 13A, 17K, 35E, 37K, 42Q, 61G, 62Y, 105Y, 108N, 144D, 146N, 156N, 158K, 160N, 163N, 164A, 199W, 201S, 202Y, 203R, 209N, 211A, 213W, 215I, 242H
CDD
cd09087 (Ape1-like_AP-endo)

160N

DNA binding site
7N, 9N, 10G, 11I, 12R, 13A, 17K, 35E, 37K, 42Q, 61G, 62Y, 105Y, 108N, 144D, 146N, 156N, 158K, 160N, 163N, 164A, 199W, 201S, 202Y, 203R, 209N, 211A, 213W, 215I, 242H
CDD
cd09087 (Ape1-like_AP-endo)

163N

DNA binding site
7N, 9N, 10G, 11I, 12R, 13A, 17K, 35E, 37K, 42Q, 61G, 62Y, 105Y, 108N, 144D, 146N, 156N, 158K, 160N, 163N, 164A, 199W, 201S, 202Y, 203R, 209N, 211A, 213W, 215I, 242H
CDD
cd09087 (Ape1-like_AP-endo)

164A

DNA binding site
7N, 9N, 10G, 11I, 12R, 13A, 17K, 35E, 37K, 42Q, 61G, 62Y, 105Y, 108N, 144D, 146N, 156N, 158K, 160N, 163N, 164A, 199W, 201S, 202Y, 203R, 209N, 211A, 213W, 215I, 242H
CDD
cd09087 (Ape1-like_AP-endo)

199W

DNA binding site
7N, 9N, 10G, 11I, 12R, 13A, 17K, 35E, 37K, 42Q, 61G, 62Y, 105Y, 108N, 144D, 146N, 156N, 158K, 160N, 163N, 164A, 199W, 201S, 202Y, 203R, 209N, 211A, 213W, 215I, 242H
CDD
cd09087 (Ape1-like_AP-endo)

201S

DNA binding site
7N, 9N, 10G, 11I, 12R, 13A, 17K, 35E, 37K, 42Q, 61G, 62Y, 105Y, 108N, 144D, 146N, 156N, 158K, 160N, 163N, 164A, 199W, 201S, 202Y, 203R, 209N, 211A, 213W, 215I, 242H
CDD
cd09087 (Ape1-like_AP-endo)

202Y

DNA binding site
7N, 9N, 10G, 11I, 12R, 13A, 17K, 35E, 37K, 42Q, 61G, 62Y, 105Y, 108N, 144D, 146N, 156N, 158K, 160N, 163N, 164A, 199W, 201S, 202Y, 203R, 209N, 211A, 213W, 215I, 242H
CDD
cd09087 (Ape1-like_AP-endo)

203R

DNA binding site
7N, 9N, 10G, 11I, 12R, 13A, 17K, 35E, 37K, 42Q, 61G, 62Y, 105Y, 108N, 144D, 146N, 156N, 158K, 160N, 163N, 164A, 199W, 201S, 202Y, 203R, 209N, 211A, 213W, 215I, 242H
CDD
cd09087 (Ape1-like_AP-endo)

209N

DNA binding site
7N, 9N, 10G, 11I, 12R, 13A, 17K, 35E, 37K, 42Q, 61G, 62Y, 105Y, 108N, 144D, 146N, 156N, 158K, 160N, 163N, 164A, 199W, 201S, 202Y, 203R, 209N, 211A, 213W, 215I, 242H
CDD
cd09087 (Ape1-like_AP-endo)

211A

DNA binding site
7N, 9N, 10G, 11I, 12R, 13A, 17K, 35E, 37K, 42Q, 61G, 62Y, 105Y, 108N, 144D, 146N, 156N, 158K, 160N, 163N, 164A, 199W, 201S, 202Y, 203R, 209N, 211A, 213W, 215I, 242H
CDD
cd09087 (Ape1-like_AP-endo)

213W

DNA binding site
7N, 9N, 10G, 11I, 12R, 13A, 17K, 35E, 37K, 42Q, 61G, 62Y, 105Y, 108N, 144D, 146N, 156N, 158K, 160N, 163N, 164A, 199W, 201S, 202Y, 203R, 209N, 211A, 213W, 215I, 242H
CDD
cd09087 (Ape1-like_AP-endo)

215I

DNA binding site
7N, 9N, 10G, 11I, 12R, 13A, 17K, 35E, 37K, 42Q, 61G, 62Y, 105Y, 108N, 144D, 146N, 156N, 158K, 160N, 163N, 164A, 199W, 201S, 202Y, 203R, 209N, 211A, 213W, 215I, 242H
CDD
cd09087 (Ape1-like_AP-endo)

242H

DNA binding site
7N, 9N, 10G, 11I, 12R, 13A, 17K, 35E, 37K, 42Q, 61G, 62Y, 105Y, 108N, 144D, 146N, 156N, 158K, 160N, 163N, 164A, 199W, 201S, 202Y, 203R, 209N, 211A, 213W, 215I, 242H
CDD
cd09087 (Ape1-like_AP-endo)
putative catalytic...

7N

putative catalytic site
7N, 35E, 105Y, 144D, 146N, 216D, 241D, 242H
CDD
cd09087 (Ape1-like_AP-endo)

35E

putative catalytic site
7N, 35E, 105Y, 144D, 146N, 216D, 241D, 242H
CDD
cd09087 (Ape1-like_AP-endo)

105Y

putative catalytic site
7N, 35E, 105Y, 144D, 146N, 216D, 241D, 242H
CDD
cd09087 (Ape1-like_AP-endo)

144D

putative catalytic site
7N, 35E, 105Y, 144D, 146N, 216D, 241D, 242H
CDD
cd09087 (Ape1-like_AP-endo)

146N

putative catalytic site
7N, 35E, 105Y, 144D, 146N, 216D, 241D, 242H
CDD
cd09087 (Ape1-like_AP-endo)

216D

putative catalytic site
7N, 35E, 105Y, 144D, 146N, 216D, 241D, 242H
CDD
cd09087 (Ape1-like_AP-endo)

241D

putative catalytic site
7N, 35E, 105Y, 144D, 146N, 216D, 241D, 242H
CDD
cd09087 (Ape1-like_AP-endo)

242H

putative catalytic site
7N, 35E, 105Y, 144D, 146N, 216D, 241D, 242H
CDD
cd09087 (Ape1-like_AP-endo)
active site cd09087

7N

active site
7N, 9N, 10G, 11I, 12R, 13A, 17K, 35E, 37K, 42Q, 61G, 62Y, 105Y, 108N, 144D, 146N, 156N, 158K, 160N, 163N, 164A, 199W, 201S, 202Y, 203R, 209N, 211A, 213W, 215I, 216D, 242H
CDD
cd09087 (Ape1-like_AP-endo)

9N

active site
7N, 9N, 10G, 11I, 12R, 13A, 17K, 35E, 37K, 42Q, 61G, 62Y, 105Y, 108N, 144D, 146N, 156N, 158K, 160N, 163N, 164A, 199W, 201S, 202Y, 203R, 209N, 211A, 213W, 215I, 216D, 242H
CDD
cd09087 (Ape1-like_AP-endo)

10G

active site
7N, 9N, 10G, 11I, 12R, 13A, 17K, 35E, 37K, 42Q, 61G, 62Y, 105Y, 108N, 144D, 146N, 156N, 158K, 160N, 163N, 164A, 199W, 201S, 202Y, 203R, 209N, 211A, 213W, 215I, 216D, 242H
CDD
cd09087 (Ape1-like_AP-endo)

11I

active site
7N, 9N, 10G, 11I, 12R, 13A, 17K, 35E, 37K, 42Q, 61G, 62Y, 105Y, 108N, 144D, 146N, 156N, 158K, 160N, 163N, 164A, 199W, 201S, 202Y, 203R, 209N, 211A, 213W, 215I, 216D, 242H
CDD
cd09087 (Ape1-like_AP-endo)

12R

active site
7N, 9N, 10G, 11I, 12R, 13A, 17K, 35E, 37K, 42Q, 61G, 62Y, 105Y, 108N, 144D, 146N, 156N, 158K, 160N, 163N, 164A, 199W, 201S, 202Y, 203R, 209N, 211A, 213W, 215I, 216D, 242H
CDD
cd09087 (Ape1-like_AP-endo)

13A

active site
7N, 9N, 10G, 11I, 12R, 13A, 17K, 35E, 37K, 42Q, 61G, 62Y, 105Y, 108N, 144D, 146N, 156N, 158K, 160N, 163N, 164A, 199W, 201S, 202Y, 203R, 209N, 211A, 213W, 215I, 216D, 242H
CDD
cd09087 (Ape1-like_AP-endo)

17K

active site
7N, 9N, 10G, 11I, 12R, 13A, 17K, 35E, 37K, 42Q, 61G, 62Y, 105Y, 108N, 144D, 146N, 156N, 158K, 160N, 163N, 164A, 199W, 201S, 202Y, 203R, 209N, 211A, 213W, 215I, 216D, 242H
CDD
cd09087 (Ape1-like_AP-endo)

35E

active site
7N, 9N, 10G, 11I, 12R, 13A, 17K, 35E, 37K, 42Q, 61G, 62Y, 105Y, 108N, 144D, 146N, 156N, 158K, 160N, 163N, 164A, 199W, 201S, 202Y, 203R, 209N, 211A, 213W, 215I, 216D, 242H
CDD
cd09087 (Ape1-like_AP-endo)

37K

active site
7N, 9N, 10G, 11I, 12R, 13A, 17K, 35E, 37K, 42Q, 61G, 62Y, 105Y, 108N, 144D, 146N, 156N, 158K, 160N, 163N, 164A, 199W, 201S, 202Y, 203R, 209N, 211A, 213W, 215I, 216D, 242H
CDD
cd09087 (Ape1-like_AP-endo)

42Q

active site
7N, 9N, 10G, 11I, 12R, 13A, 17K, 35E, 37K, 42Q, 61G, 62Y, 105Y, 108N, 144D, 146N, 156N, 158K, 160N, 163N, 164A, 199W, 201S, 202Y, 203R, 209N, 211A, 213W, 215I, 216D, 242H
CDD
cd09087 (Ape1-like_AP-endo)

61G

active site
7N, 9N, 10G, 11I, 12R, 13A, 17K, 35E, 37K, 42Q, 61G, 62Y, 105Y, 108N, 144D, 146N, 156N, 158K, 160N, 163N, 164A, 199W, 201S, 202Y, 203R, 209N, 211A, 213W, 215I, 216D, 242H
CDD
cd09087 (Ape1-like_AP-endo)

62Y

active site
7N, 9N, 10G, 11I, 12R, 13A, 17K, 35E, 37K, 42Q, 61G, 62Y, 105Y, 108N, 144D, 146N, 156N, 158K, 160N, 163N, 164A, 199W, 201S, 202Y, 203R, 209N, 211A, 213W, 215I, 216D, 242H
CDD
cd09087 (Ape1-like_AP-endo)

105Y

active site
7N, 9N, 10G, 11I, 12R, 13A, 17K, 35E, 37K, 42Q, 61G, 62Y, 105Y, 108N, 144D, 146N, 156N, 158K, 160N, 163N, 164A, 199W, 201S, 202Y, 203R, 209N, 211A, 213W, 215I, 216D, 242H
CDD
cd09087 (Ape1-like_AP-endo)

108N

active site
7N, 9N, 10G, 11I, 12R, 13A, 17K, 35E, 37K, 42Q, 61G, 62Y, 105Y, 108N, 144D, 146N, 156N, 158K, 160N, 163N, 164A, 199W, 201S, 202Y, 203R, 209N, 211A, 213W, 215I, 216D, 242H
CDD
cd09087 (Ape1-like_AP-endo)

144D

active site
7N, 9N, 10G, 11I, 12R, 13A, 17K, 35E, 37K, 42Q, 61G, 62Y, 105Y, 108N, 144D, 146N, 156N, 158K, 160N, 163N, 164A, 199W, 201S, 202Y, 203R, 209N, 211A, 213W, 215I, 216D, 242H
CDD
cd09087 (Ape1-like_AP-endo)

146N

active site
7N, 9N, 10G, 11I, 12R, 13A, 17K, 35E, 37K, 42Q, 61G, 62Y, 105Y, 108N, 144D, 146N, 156N, 158K, 160N, 163N, 164A, 199W, 201S, 202Y, 203R, 209N, 211A, 213W, 215I, 216D, 242H
CDD
cd09087 (Ape1-like_AP-endo)

156N

active site
7N, 9N, 10G, 11I, 12R, 13A, 17K, 35E, 37K, 42Q, 61G, 62Y, 105Y, 108N, 144D, 146N, 156N, 158K, 160N, 163N, 164A, 199W, 201S, 202Y, 203R, 209N, 211A, 213W, 215I, 216D, 242H
CDD
cd09087 (Ape1-like_AP-endo)

158K

active site
7N, 9N, 10G, 11I, 12R, 13A, 17K, 35E, 37K, 42Q, 61G, 62Y, 105Y, 108N, 144D, 146N, 156N, 158K, 160N, 163N, 164A, 199W, 201S, 202Y, 203R, 209N, 211A, 213W, 215I, 216D, 242H
CDD
cd09087 (Ape1-like_AP-endo)

160N

active site
7N, 9N, 10G, 11I, 12R, 13A, 17K, 35E, 37K, 42Q, 61G, 62Y, 105Y, 108N, 144D, 146N, 156N, 158K, 160N, 163N, 164A, 199W, 201S, 202Y, 203R, 209N, 211A, 213W, 215I, 216D, 242H
CDD
cd09087 (Ape1-like_AP-endo)

163N

active site
7N, 9N, 10G, 11I, 12R, 13A, 17K, 35E, 37K, 42Q, 61G, 62Y, 105Y, 108N, 144D, 146N, 156N, 158K, 160N, 163N, 164A, 199W, 201S, 202Y, 203R, 209N, 211A, 213W, 215I, 216D, 242H
CDD
cd09087 (Ape1-like_AP-endo)

164A

active site
7N, 9N, 10G, 11I, 12R, 13A, 17K, 35E, 37K, 42Q, 61G, 62Y, 105Y, 108N, 144D, 146N, 156N, 158K, 160N, 163N, 164A, 199W, 201S, 202Y, 203R, 209N, 211A, 213W, 215I, 216D, 242H
CDD
cd09087 (Ape1-like_AP-endo)

199W

active site
7N, 9N, 10G, 11I, 12R, 13A, 17K, 35E, 37K, 42Q, 61G, 62Y, 105Y, 108N, 144D, 146N, 156N, 158K, 160N, 163N, 164A, 199W, 201S, 202Y, 203R, 209N, 211A, 213W, 215I, 216D, 242H
CDD
cd09087 (Ape1-like_AP-endo)

201S

active site
7N, 9N, 10G, 11I, 12R, 13A, 17K, 35E, 37K, 42Q, 61G, 62Y, 105Y, 108N, 144D, 146N, 156N, 158K, 160N, 163N, 164A, 199W, 201S, 202Y, 203R, 209N, 211A, 213W, 215I, 216D, 242H
CDD
cd09087 (Ape1-like_AP-endo)

202Y

active site
7N, 9N, 10G, 11I, 12R, 13A, 17K, 35E, 37K, 42Q, 61G, 62Y, 105Y, 108N, 144D, 146N, 156N, 158K, 160N, 163N, 164A, 199W, 201S, 202Y, 203R, 209N, 211A, 213W, 215I, 216D, 242H
CDD
cd09087 (Ape1-like_AP-endo)

203R

active site
7N, 9N, 10G, 11I, 12R, 13A, 17K, 35E, 37K, 42Q, 61G, 62Y, 105Y, 108N, 144D, 146N, 156N, 158K, 160N, 163N, 164A, 199W, 201S, 202Y, 203R, 209N, 211A, 213W, 215I, 216D, 242H
CDD
cd09087 (Ape1-like_AP-endo)

209N

active site
7N, 9N, 10G, 11I, 12R, 13A, 17K, 35E, 37K, 42Q, 61G, 62Y, 105Y, 108N, 144D, 146N, 156N, 158K, 160N, 163N, 164A, 199W, 201S, 202Y, 203R, 209N, 211A, 213W, 215I, 216D, 242H
CDD
cd09087 (Ape1-like_AP-endo)

211A

active site
7N, 9N, 10G, 11I, 12R, 13A, 17K, 35E, 37K, 42Q, 61G, 62Y, 105Y, 108N, 144D, 146N, 156N, 158K, 160N, 163N, 164A, 199W, 201S, 202Y, 203R, 209N, 211A, 213W, 215I, 216D, 242H
CDD
cd09087 (Ape1-like_AP-endo)

213W

active site
7N, 9N, 10G, 11I, 12R, 13A, 17K, 35E, 37K, 42Q, 61G, 62Y, 105Y, 108N, 144D, 146N, 156N, 158K, 160N, 163N, 164A, 199W, 201S, 202Y, 203R, 209N, 211A, 213W, 215I, 216D, 242H
CDD
cd09087 (Ape1-like_AP-endo)

215I

active site
7N, 9N, 10G, 11I, 12R, 13A, 17K, 35E, 37K, 42Q, 61G, 62Y, 105Y, 108N, 144D, 146N, 156N, 158K, 160N, 163N, 164A, 199W, 201S, 202Y, 203R, 209N, 211A, 213W, 215I, 216D, 242H
CDD
cd09087 (Ape1-like_AP-endo)

216D

active site
7N, 9N, 10G, 11I, 12R, 13A, 17K, 35E, 37K, 42Q, 61G, 62Y, 105Y, 108N, 144D, 146N, 156N, 158K, 160N, 163N, 164A, 199W, 201S, 202Y, 203R, 209N, 211A, 213W, 215I, 216D, 242H
CDD
cd09087 (Ape1-like_AP-endo)

242H

active site
7N, 9N, 10G, 11I, 12R, 13A, 17K, 35E, 37K, 42Q, 61G, 62Y, 105Y, 108N, 144D, 146N, 156N, 158K, 160N, 163N, 164A, 199W, 201S, 202Y, 203R, 209N, 211A, 213W, 215I, 216D, 242H
CDD
cd09087 (Ape1-like_AP-endo)
metal binding site...

9N

metal binding site A
9N, 35E, 241D
CDD
cd09087 (Ape1-like_AP-endo)

35E

metal binding site A
9N, 35E, 241D
CDD
cd09087 (Ape1-like_AP-endo)

241D

metal binding site A
9N, 35E, 241D
CDD
cd09087 (Ape1-like_AP-endo)
AP binding site cd...

105Y

AP binding site
105Y, 108N, 144D, 146N, 164A, 199W, 213W, 215I, 242H
CDD
cd09087 (Ape1-like_AP-endo)

108N

AP binding site
105Y, 108N, 144D, 146N, 164A, 199W, 213W, 215I, 242H
CDD
cd09087 (Ape1-like_AP-endo)

144D

AP binding site
105Y, 108N, 144D, 146N, 164A, 199W, 213W, 215I, 242H
CDD
cd09087 (Ape1-like_AP-endo)

146N

AP binding site
105Y, 108N, 144D, 146N, 164A, 199W, 213W, 215I, 242H
CDD
cd09087 (Ape1-like_AP-endo)

164A

AP binding site
105Y, 108N, 144D, 146N, 164A, 199W, 213W, 215I, 242H
CDD
cd09087 (Ape1-like_AP-endo)

199W

AP binding site
105Y, 108N, 144D, 146N, 164A, 199W, 213W, 215I, 242H
CDD
cd09087 (Ape1-like_AP-endo)

213W

AP binding site
105Y, 108N, 144D, 146N, 164A, 199W, 213W, 215I, 242H
CDD
cd09087 (Ape1-like_AP-endo)

215I

AP binding site
105Y, 108N, 144D, 146N, 164A, 199W, 213W, 215I, 242H
CDD
cd09087 (Ape1-like_AP-endo)

242H

AP binding site
105Y, 108N, 144D, 146N, 164A, 199W, 213W, 215I, 242H
CDD
cd09087 (Ape1-like_AP-endo)
metal binding site...

144D

metal binding site B
144D, 146N, 242H
CDD
cd09087 (Ape1-like_AP-endo)

146N

metal binding site B
144D, 146N, 242H
CDD
cd09087 (Ape1-like_AP-endo)

242H

metal binding site B
144D, 146N, 242H
CDD
cd09087 (Ape1-like_AP-endo)

GO term prediction

Biological Process

GO:0006281 DNA repair

Molecular Function

GO:0003677 DNA binding
GO:0004518 nuclease activity
GO:0004519 endonuclease activity

Cellular Component

GO:0005622 intracellular

Filter view on

Entry type

Status

Per-residue features

25586_FusoPortal_Gene_358

Protein family membership

Homologous superfamilies

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component