25586_FusoPortal_Gene_407

Protein

25586_FusoPortal_Gene_407

Length

635 amino acids

Protein family membership

DNA topoisomerase, type IIA (IPR001241)
- DNA topoisomerase, type IIA, subunit B (IPR000565)
  - DNA gyrase, subunit B (IPR011557)

Homologous superfamilies

Homologous superfamily
3 - 218
Histidine kinase/HSP90-like ATPase superfamily (IPR036890)
220 - 392
Ribosomal protein S5 domain 2-type fold, subgroup (IPR014721)
400 - 632
DNA topoisomerase, type IIA, subunit B, C-terminal (IPR013759)
Homologous superfamily
221 - 391
Ribosomal protein S5 domain 2-type fold (IPR020568)
394 - 628
DNA topoisomerase, type IIA-like domain superfamily (IPR013760)

1 100 200 300 400 500 635

Domains and repeats

Domain
29 - 172
Histidine kinase/HSP90-like ATPase (IPR003594)
221 - 390
DNA topoisomerase, type IIA, subunit B, domain 2 (IPR013506)
418 - 532
TOPRIM domain (IPR006171)
DNA gyrase subunit B, TOPRIM domain (IPR034160)
562 - 624
DNA gyrase B subunit, C-terminal (IPR002288)

1 100 200 300 400 500 635

Detailed signature matches

IPR036890

Histidine kinase/HSP90-like ATPase superfamily
1. G3DSA:3.30.56...
  
  15 - 218
  
  GENE3D
  G3DSA:3.30.565.10 (G3DSA:3.30.565.10)
2. SSF55874 (ATPase do...)
  
  3 - 216
  
  SUPERFAMILY
  SSF55874 (ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase)
IPR014721

Ribosomal protein S5 domain 2-type fold, subgroup
1. G3DSA:3.30.23...
  
  220 - 392
  
  GENE3D
  G3DSA:3.30.230.10 (G3DSA:3.30.230.10)
IPR020568

Ribosomal protein S5 domain 2-type fold
1. SSF54211 (Ribosomal...)
  
  221 - 391
  
  SUPERFAMILY
  SSF54211 (Ribosomal protein S5 domain 2-like)
IPR013760

DNA topoisomerase, type IIA-like domain superfamily
1. SSF56719 (Type II D...)
  
  394 - 628
  
  SUPERFAMILY
  SSF56719 (Type II DNA topoisomerase)
IPR013759

DNA topoisomerase, type IIA, subunit B, C-terminal
1. G3DSA:3.40.50...
  
  400 - 632
  
  GENE3D
  G3DSA:3.40.50.670 (G3DSA:3.40.50.670)
IPR001241

DNA topoisomerase, type IIA
1. PTHR10169 (DNA TOPO...)
  
  2 - 632
  
  PANTHER
  PTHR10169 (DNA TOPOISOMERASE/GYRASE)
IPR000565

DNA topoisomerase, type IIA, subunit B
1. PR01159 (DNAGYRASEB)
  
  374 - 394
  
  PRINTS
  PR01159 (DNAGYRASEB)
  
  470 - 479
  
  PRINTS
  PR01159 (DNAGYRASEB)
  
  588 - 600
  
  PRINTS
  PR01159 (DNAGYRASEB)
  
  179 - 194
  
  PRINTS
  PR01159 (DNAGYRASEB)
  
  360 - 374
  
  PRINTS
  PR01159 (DNAGYRASEB)
  
  604 - 620
  
  PRINTS
  PR01159 (DNAGYRASEB)
  
  3 - 13
  
  PRINTS
  PR01159 (DNAGYRASEB)
  
  220 - 242
  
  PRINTS
  PR01159 (DNAGYRASEB)
  
  312 - 328
  
  PRINTS
  PR01159 (DNAGYRASEB)
  
  194 - 207
  
  PRINTS
  PR01159 (DNAGYRASEB)
IPR011557

DNA gyrase, subunit B
1. TIGR01059
  
  3 - 635
  
  TIGRFAMs
  TIGR01059 (TIGR01059)
2. MF_01898 (GyrB)
  
  2 - 635
  
  HAMAP
  MF_01898 (GyrB)
IPR003594

Histidine kinase/HSP90-like ATPase
1. PF02518 (HATPase_c)
  
  29 - 172
  
  Pfam
  PF02518 (HATPase_c)
2. cd00075 (HATPase_c)
  
  33 - 135
  
  CDD
  cd00075 (HATPase_c)
IPR013506

DNA topoisomerase, type IIA, subunit B, domain 2
1. PF00204 (DNA_gyraseB)
  
  221 - 390
  
  Pfam
  PF00204 (DNA_gyraseB)
IPR006171

TOPRIM domain
1. PF01751 (Toprim)
  
  419 - 527
  
  Pfam
  PF01751 (Toprim)
2. PS50880 (TOPRIM)
  
  418 - 532
  
  PROSITE profiles
  PS50880 (TOPRIM)
IPR034160

DNA gyrase subunit B, TOPRIM domain
1. cd03366 (TOPRIM_Top...)
  
  418 - 531
  
  CDD
  cd03366 (TOPRIM_TopoIIA_GyrB)
IPR002288

DNA gyrase B subunit, C-terminal
1. PF00986 (DNA_gyraseB_C)
  
  562 - 624
  
  Pfam
  PF00986 (DNA_gyraseB_C)
IPR018522

DNA topoisomerase, type IIA, conserved site
1. PS00177 (TOPOISOMER...)
  
  422 - 430
  
  PROSITE patterns
  PS00177 (TOPOISOMERASE_II)

no IPR

Unintegrated signatures

PR00418 (TPI2FAMILY)

110 - 124

PRINTS
PR00418 (TPI2FAMILY)

504 - 521

PRINTS
PR00418 (TPI2FAMILY)

567 - 583

PRINTS
PR00418 (TPI2FAMILY)

524 - 536

PRINTS
PR00418 (TPI2FAMILY)

32 - 47

PRINTS
PR00418 (TPI2FAMILY)

67 - 80

PRINTS
PR00418 (TPI2FAMILY)

268 - 281

PRINTS
PR00418 (TPI2FAMILY)

420 - 434

PRINTS
PR00418 (TPI2FAMILY)

486 - 502

PRINTS
PR00418 (TPI2FAMILY)
PTHR10169:SF20 (DNA...)

2 - 632

PANTHER
PTHR10169:SF20 (DNA GYRASE SUBUNIT B)
cd00822 (TopoII_Tra...)

220 - 391

CDD
cd00822 (TopoII_Trans_DNA_gyrase)

Residue annotation

ATP binding site c...

39E

ATP binding site
39E, 43N, 46D, 68V, 70D, 72G, 74G, 75I, 114G, 115V, 116G, 117V, 129V, 131V
CDD
cd00075 (HATPase_c)

43N

ATP binding site
39E, 43N, 46D, 68V, 70D, 72G, 74G, 75I, 114G, 115V, 116G, 117V, 129V, 131V
CDD
cd00075 (HATPase_c)

46D

ATP binding site
39E, 43N, 46D, 68V, 70D, 72G, 74G, 75I, 114G, 115V, 116G, 117V, 129V, 131V
CDD
cd00075 (HATPase_c)

68V

ATP binding site
39E, 43N, 46D, 68V, 70D, 72G, 74G, 75I, 114G, 115V, 116G, 117V, 129V, 131V
CDD
cd00075 (HATPase_c)

70D

ATP binding site
39E, 43N, 46D, 68V, 70D, 72G, 74G, 75I, 114G, 115V, 116G, 117V, 129V, 131V
CDD
cd00075 (HATPase_c)

72G

ATP binding site
39E, 43N, 46D, 68V, 70D, 72G, 74G, 75I, 114G, 115V, 116G, 117V, 129V, 131V
CDD
cd00075 (HATPase_c)

74G

ATP binding site
39E, 43N, 46D, 68V, 70D, 72G, 74G, 75I, 114G, 115V, 116G, 117V, 129V, 131V
CDD
cd00075 (HATPase_c)

75I

ATP binding site
39E, 43N, 46D, 68V, 70D, 72G, 74G, 75I, 114G, 115V, 116G, 117V, 129V, 131V
CDD
cd00075 (HATPase_c)

114G

ATP binding site
39E, 43N, 46D, 68V, 70D, 72G, 74G, 75I, 114G, 115V, 116G, 117V, 129V, 131V
CDD
cd00075 (HATPase_c)

115V

ATP binding site
39E, 43N, 46D, 68V, 70D, 72G, 74G, 75I, 114G, 115V, 116G, 117V, 129V, 131V
CDD
cd00075 (HATPase_c)

116G

ATP binding site
39E, 43N, 46D, 68V, 70D, 72G, 74G, 75I, 114G, 115V, 116G, 117V, 129V, 131V
CDD
cd00075 (HATPase_c)

117V

ATP binding site
39E, 43N, 46D, 68V, 70D, 72G, 74G, 75I, 114G, 115V, 116G, 117V, 129V, 131V
CDD
cd00075 (HATPase_c)

129V

ATP binding site
39E, 43N, 46D, 68V, 70D, 72G, 74G, 75I, 114G, 115V, 116G, 117V, 129V, 131V
CDD
cd00075 (HATPase_c)

131V

ATP binding site
39E, 43N, 46D, 68V, 70D, 72G, 74G, 75I, 114G, 115V, 116G, 117V, 129V, 131V
CDD
cd00075 (HATPase_c)
Mg2+ binding site ...

43N

Mg2+ binding site
43N
CDD
cd00075 (HATPase_c)
G-X-G motif cd00075

72G

G-X-G motif
72G, 74G, 114G, 116G
CDD
cd00075 (HATPase_c)

74G

G-X-G motif
72G, 74G, 114G, 116G
CDD
cd00075 (HATPase_c)

114G

G-X-G motif
72G, 74G, 114G, 116G
CDD
cd00075 (HATPase_c)

116G

G-X-G motif
72G, 74G, 114G, 116G
CDD
cd00075 (HATPase_c)
anchoring element ...

271N

anchoring element
271N
CDD
cd00822 (TopoII_Trans_DNA_gyrase)
dimer interface cd...

329Q

dimer interface
329Q, 332F, 333E, 335Q, 380K, 381A, 385A, 389R
CDD
cd00822 (TopoII_Trans_DNA_gyrase)

332F

dimer interface
329Q, 332F, 333E, 335Q, 380K, 381A, 385A, 389R
CDD
cd00822 (TopoII_Trans_DNA_gyrase)

333E

dimer interface
329Q, 332F, 333E, 335Q, 380K, 381A, 385A, 389R
CDD
cd00822 (TopoII_Trans_DNA_gyrase)

335Q

dimer interface
329Q, 332F, 333E, 335Q, 380K, 381A, 385A, 389R
CDD
cd00822 (TopoII_Trans_DNA_gyrase)

380K

dimer interface
329Q, 332F, 333E, 335Q, 380K, 381A, 385A, 389R
CDD
cd00822 (TopoII_Trans_DNA_gyrase)

381A

dimer interface
329Q, 332F, 333E, 335Q, 380K, 381A, 385A, 389R
CDD
cd00822 (TopoII_Trans_DNA_gyrase)

385A

dimer interface
329Q, 332F, 333E, 335Q, 380K, 381A, 385A, 389R
CDD
cd00822 (TopoII_Trans_DNA_gyrase)

389R

dimer interface
329Q, 332F, 333E, 335Q, 380K, 381A, 385A, 389R
CDD
cd00822 (TopoII_Trans_DNA_gyrase)
ATP binding site c...

335Q

ATP binding site
335Q, 337K
CDD
cd00822 (TopoII_Trans_DNA_gyrase)

337K

ATP binding site
335Q, 337K
CDD
cd00822 (TopoII_Trans_DNA_gyrase)
putative metal-bin...

424E

putative metal-binding site
424E, 497D
CDD
cd03366 (TOPRIM_TopoIIA_GyrB)

497D

putative metal-binding site
424E, 497D
CDD
cd03366 (TOPRIM_TopoIIA_GyrB)
active site cd03366

424E

active site
424E, 425G, 428A, 497D, 499D, 501D
CDD
cd03366 (TOPRIM_TopoIIA_GyrB)

425G

active site
424E, 425G, 428A, 497D, 499D, 501D
CDD
cd03366 (TOPRIM_TopoIIA_GyrB)

428A

active site
424E, 425G, 428A, 497D, 499D, 501D
CDD
cd03366 (TOPRIM_TopoIIA_GyrB)

497D

active site
424E, 425G, 428A, 497D, 499D, 501D
CDD
cd03366 (TOPRIM_TopoIIA_GyrB)

499D

active site
424E, 425G, 428A, 497D, 499D, 501D
CDD
cd03366 (TOPRIM_TopoIIA_GyrB)

501D

active site
424E, 425G, 428A, 497D, 499D, 501D
CDD
cd03366 (TOPRIM_TopoIIA_GyrB)

GO term prediction

Biological Process

GO:0006265 DNA topological change

Molecular Function

GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity
GO:0005524 ATP binding

Cellular Component

GO:0005694 chromosome

Filter view on

Entry type

Status

Per-residue features

25586_FusoPortal_Gene_407

Protein family membership

Homologous superfamilies

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component