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Entry type
Status
Per-residue features
Colour by
25586_FusoPortal_Gene_72
Length
473 amino acids
Protein family membership
- Cysteinyl-tRNA synthetase/mycothiol ligase (IPR024909)
- Cysteine-tRNA ligase (IPR015803)
Homologous superfamilies
-
Homologous superfamily
1
50
100
150
200
250
300
350
400
473
Domains and repeats
-
Domain3 - 314
- tRNA synthetases class I, catalytic domain (IPR032678)
354 - 420- Cysteinyl-tRNA synthetase, class Ia, DALR (IPR015273)
1
50
100
150
200
250
300
350
400
473
Detailed signature matches
-
-
1 - 306
-

Unintegrated signatures
-
307 - 412
-
PTHR10890:SF21 (CYS...)2 - 472
-
SSF52374 (Nucleotid...)2 - 313
Residue annotation
-
active site cd0067228Cactive site
28C, 29G, 30P, 31T, 37H, 39G, 40N, 43P, 44A, 66N, 68T, 206W, 210C, 227G, 228G, 230D, 231L, 235H, 259G, 260Y, 261I
CDD
cd00672 (CysRS_core)29Gactive site
28C, 29G, 30P, 31T, 37H, 39G, 40N, 43P, 44A, 66N, 68T, 206W, 210C, 227G, 228G, 230D, 231L, 235H, 259G, 260Y, 261I
CDD
cd00672 (CysRS_core)30Pactive site
28C, 29G, 30P, 31T, 37H, 39G, 40N, 43P, 44A, 66N, 68T, 206W, 210C, 227G, 228G, 230D, 231L, 235H, 259G, 260Y, 261I
CDD
cd00672 (CysRS_core)31Tactive site
28C, 29G, 30P, 31T, 37H, 39G, 40N, 43P, 44A, 66N, 68T, 206W, 210C, 227G, 228G, 230D, 231L, 235H, 259G, 260Y, 261I
CDD
cd00672 (CysRS_core)37Hactive site
28C, 29G, 30P, 31T, 37H, 39G, 40N, 43P, 44A, 66N, 68T, 206W, 210C, 227G, 228G, 230D, 231L, 235H, 259G, 260Y, 261I
CDD
cd00672 (CysRS_core)39Gactive site
28C, 29G, 30P, 31T, 37H, 39G, 40N, 43P, 44A, 66N, 68T, 206W, 210C, 227G, 228G, 230D, 231L, 235H, 259G, 260Y, 261I
CDD
cd00672 (CysRS_core)40Nactive site
28C, 29G, 30P, 31T, 37H, 39G, 40N, 43P, 44A, 66N, 68T, 206W, 210C, 227G, 228G, 230D, 231L, 235H, 259G, 260Y, 261I
CDD
cd00672 (CysRS_core)43Pactive site
28C, 29G, 30P, 31T, 37H, 39G, 40N, 43P, 44A, 66N, 68T, 206W, 210C, 227G, 228G, 230D, 231L, 235H, 259G, 260Y, 261I
CDD
cd00672 (CysRS_core)44Aactive site
28C, 29G, 30P, 31T, 37H, 39G, 40N, 43P, 44A, 66N, 68T, 206W, 210C, 227G, 228G, 230D, 231L, 235H, 259G, 260Y, 261I
CDD
cd00672 (CysRS_core)66Nactive site
28C, 29G, 30P, 31T, 37H, 39G, 40N, 43P, 44A, 66N, 68T, 206W, 210C, 227G, 228G, 230D, 231L, 235H, 259G, 260Y, 261I
CDD
cd00672 (CysRS_core)68Tactive site
28C, 29G, 30P, 31T, 37H, 39G, 40N, 43P, 44A, 66N, 68T, 206W, 210C, 227G, 228G, 230D, 231L, 235H, 259G, 260Y, 261I
CDD
cd00672 (CysRS_core)206Wactive site
28C, 29G, 30P, 31T, 37H, 39G, 40N, 43P, 44A, 66N, 68T, 206W, 210C, 227G, 228G, 230D, 231L, 235H, 259G, 260Y, 261I
CDD
cd00672 (CysRS_core)210Cactive site
28C, 29G, 30P, 31T, 37H, 39G, 40N, 43P, 44A, 66N, 68T, 206W, 210C, 227G, 228G, 230D, 231L, 235H, 259G, 260Y, 261I
CDD
cd00672 (CysRS_core)227Gactive site
28C, 29G, 30P, 31T, 37H, 39G, 40N, 43P, 44A, 66N, 68T, 206W, 210C, 227G, 228G, 230D, 231L, 235H, 259G, 260Y, 261I
CDD
cd00672 (CysRS_core)228Gactive site
28C, 29G, 30P, 31T, 37H, 39G, 40N, 43P, 44A, 66N, 68T, 206W, 210C, 227G, 228G, 230D, 231L, 235H, 259G, 260Y, 261I
CDD
cd00672 (CysRS_core)230Dactive site
28C, 29G, 30P, 31T, 37H, 39G, 40N, 43P, 44A, 66N, 68T, 206W, 210C, 227G, 228G, 230D, 231L, 235H, 259G, 260Y, 261I
CDD
cd00672 (CysRS_core)231Lactive site
28C, 29G, 30P, 31T, 37H, 39G, 40N, 43P, 44A, 66N, 68T, 206W, 210C, 227G, 228G, 230D, 231L, 235H, 259G, 260Y, 261I
CDD
cd00672 (CysRS_core)235Hactive site
28C, 29G, 30P, 31T, 37H, 39G, 40N, 43P, 44A, 66N, 68T, 206W, 210C, 227G, 228G, 230D, 231L, 235H, 259G, 260Y, 261I
CDD
cd00672 (CysRS_core)259Gactive site
28C, 29G, 30P, 31T, 37H, 39G, 40N, 43P, 44A, 66N, 68T, 206W, 210C, 227G, 228G, 230D, 231L, 235H, 259G, 260Y, 261I
CDD
cd00672 (CysRS_core)260Yactive site
28C, 29G, 30P, 31T, 37H, 39G, 40N, 43P, 44A, 66N, 68T, 206W, 210C, 227G, 228G, 230D, 231L, 235H, 259G, 260Y, 261I
CDD
cd00672 (CysRS_core)261Iactive site
28C, 29G, 30P, 31T, 37H, 39G, 40N, 43P, 44A, 66N, 68T, 206W, 210C, 227G, 228G, 230D, 231L, 235H, 259G, 260Y, 261I
CDD
cd00672 (CysRS_core) -
HIGH motif cd00672
-
KMSKS motif cd00672267K268M269S270K271S
GO term prediction
Biological Process
GO:0006418 tRNA aminoacylation for protein translation
GO:0006423 cysteinyl-tRNA aminoacylation
Molecular Function
GO:0000166 nucleotide binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004817 cysteine-tRNA ligase activity
GO:0005524 ATP binding
Cellular Component
GO:0005737 cytoplasm