25586_FusoPortal_Gene_855

Protein

25586_FusoPortal_Gene_855

Length

592 amino acids

Protein family membership

Aspartyl/Asparaginyl-tRNA synthetase, class IIb (IPR002312)
- Aspartate-tRNA ligase, type 1 (IPR004524)

Homologous superfamilies

Homologous superfamily
2 - 112
Nucleic acid-binding, OB-fold (IPR012340)
295 - 423
GAD-like domain superfamily (IPR004115)

1 100 200 300 400 500 592

Domains and repeats

Domain
20 - 105
OB-fold nucleic acid binding domain, AA-tRNA synthetase-type (IPR004365)
314 - 409
GAD domain (IPR029351)
Domain
124 - 562
Aminoacyl-tRNA synthetase, class II (IPR006195)
Aminoacyl-tRNA synthetase, class II (D/K/N) (IPR004364)

1 100 200 300 400 500 592

Detailed signature matches

IPR012340

Nucleic acid-binding, OB-fold
1. SSF50249 (Nucleic a...)
  
  2 - 112
  
  SUPERFAMILY
  SSF50249 (Nucleic acid-binding proteins)
IPR004115

GAD-like domain superfamily
1. SSF55261 (GAD domai...)
  
  295 - 423
  
  SUPERFAMILY
  SSF55261 (GAD domain-like)
IPR002312

Aspartyl/Asparaginyl-tRNA synthetase, class IIb
1. PR01042 (TRNASYNTHASP)
  
  479 - 495
  
  PRINTS
  PR01042 (TRNASYNTHASP)
  
  213 - 226
  
  PRINTS
  PR01042 (TRNASYNTHASP)
  
  523 - 537
  
  PRINTS
  PR01042 (TRNASYNTHASP)
  
  196 - 208
  
  PRINTS
  PR01042 (TRNASYNTHASP)
IPR004524

Aspartate-tRNA ligase, type 1
1. MF_00044 (Asp_tRNA_...)
  
  3 - 589
  
  HAMAP
  MF_00044 (Asp_tRNA_synth_type1)
2. PTHR22594:SF5 (ASPA...)
  
  2 - 588
  
  PANTHER
  PTHR22594:SF5 (ASPARTATE--TRNA LIGASE, MITOCHONDRIAL)
3. TIGR00459
  
  4 - 587
  
  TIGRFAMs
  TIGR00459 (TIGR00459)
IPR004365

OB-fold nucleic acid binding domain, AA-tRNA synthetase-type
1. PF01336 (tRNA_anti-...)
  
  20 - 105
  
  Pfam
  PF01336 (tRNA_anti-codon)
IPR006195

Aminoacyl-tRNA synthetase, class II
1. PS50862 (AA_TRNA_LI...)
  
  144 - 558
  
  PROSITE profiles
  PS50862 (AA_TRNA_LIGASE_II)
IPR004364

Aminoacyl-tRNA synthetase, class II (D/K/N)
1. PF00152 (tRNA-synt_2)
  
  124 - 562
  
  Pfam
  PF00152 (tRNA-synt_2)
IPR029351

GAD domain
1. PF02938 (GAD)
  
  314 - 409
  
  Pfam
  PF02938 (GAD)

no IPR

Unintegrated signatures

G3DSA:2.40.50...

2 - 111

GENE3D
G3DSA:2.40.50.140 (G3DSA:2.40.50.140)
G3DSA:3.30.93...

137 - 342

GENE3D
G3DSA:3.30.930.10 (G3DSA:3.30.930.10)

343 - 591

GENE3D
G3DSA:3.30.930.10 (G3DSA:3.30.930.10)
PTHR22594 (ASPARTYL...)

2 - 588

PANTHER
PTHR22594 (ASPARTYL/LYSYL-TRNA SYNTHETASE)
SSF55681 (Class II ...)

428 - 588

SUPERFAMILY
SSF55681 (Class II aaRS and biotin synthetases)

119 - 298

SUPERFAMILY
SSF55681 (Class II aaRS and biotin synthetases)
cd00777 (AspRS_core)

144 - 564

CDD
cd00777 (AspRS_core)
cd04317 (EcAspRS_li...)

4 - 140

CDD
cd04317 (EcAspRS_like_N)

Residue annotation

dimer interface cd...

4R

dimer interface
4R, 7N, 25W, 44R, 106N, 108C, 109D
CDD
cd04317 (EcAspRS_like_N)

7N

dimer interface
4R, 7N, 25W, 44R, 106N, 108C, 109D
CDD
cd04317 (EcAspRS_like_N)

25W

dimer interface
4R, 7N, 25W, 44R, 106N, 108C, 109D
CDD
cd04317 (EcAspRS_like_N)

44R

dimer interface
4R, 7N, 25W, 44R, 106N, 108C, 109D
CDD
cd04317 (EcAspRS_like_N)

106N

dimer interface
4R, 7N, 25W, 44R, 106N, 108C, 109D
CDD
cd04317 (EcAspRS_like_N)

108C

dimer interface
4R, 7N, 25W, 44R, 106N, 108C, 109D
CDD
cd04317 (EcAspRS_like_N)

109D

dimer interface
4R, 7N, 25W, 44R, 106N, 108C, 109D
CDD
cd04317 (EcAspRS_like_N)
anticodon binding ...

28T

anticodon binding site
28T, 30R, 31N, 32V, 38F, 49Q, 69K, 83R, 87N, 96E, 112P
CDD
cd04317 (EcAspRS_like_N)

30R

anticodon binding site
28T, 30R, 31N, 32V, 38F, 49Q, 69K, 83R, 87N, 96E, 112P
CDD
cd04317 (EcAspRS_like_N)

31N

anticodon binding site
28T, 30R, 31N, 32V, 38F, 49Q, 69K, 83R, 87N, 96E, 112P
CDD
cd04317 (EcAspRS_like_N)

32V

anticodon binding site
28T, 30R, 31N, 32V, 38F, 49Q, 69K, 83R, 87N, 96E, 112P
CDD
cd04317 (EcAspRS_like_N)

38F

anticodon binding site
28T, 30R, 31N, 32V, 38F, 49Q, 69K, 83R, 87N, 96E, 112P
CDD
cd04317 (EcAspRS_like_N)

49Q

anticodon binding site
28T, 30R, 31N, 32V, 38F, 49Q, 69K, 83R, 87N, 96E, 112P
CDD
cd04317 (EcAspRS_like_N)

69K

anticodon binding site
28T, 30R, 31N, 32V, 38F, 49Q, 69K, 83R, 87N, 96E, 112P
CDD
cd04317 (EcAspRS_like_N)

83R

anticodon binding site
28T, 30R, 31N, 32V, 38F, 49Q, 69K, 83R, 87N, 96E, 112P
CDD
cd04317 (EcAspRS_like_N)

87N

anticodon binding site
28T, 30R, 31N, 32V, 38F, 49Q, 69K, 83R, 87N, 96E, 112P
CDD
cd04317 (EcAspRS_like_N)

96E

anticodon binding site
28T, 30R, 31N, 32V, 38F, 49Q, 69K, 83R, 87N, 96E, 112P
CDD
cd04317 (EcAspRS_like_N)

112P

anticodon binding site
28T, 30R, 31N, 32V, 38F, 49Q, 69K, 83R, 87N, 96E, 112P
CDD
cd04317 (EcAspRS_like_N)
homodimer interfac...

147R

homodimer interface
147R, 148H, 149R, 152M, 155R, 156N, 159D, 162G, 163F, 164L, 165D, 167D, 168T, 169P, 170V, 171L, 172T, 173K, 180R, 183L, 184V, 185P, 186S, 187R, 191G, 192T, 193F, 194Y, 209I, 210G, 213E, 214K, 220K, 224D, 234E, 244F, 249D, 521F, 524D, 525A, 527K, 528Y, 529G, 530A, 558P, 559F, 561K
CDD
cd00777 (AspRS_core)

148H

homodimer interface
147R, 148H, 149R, 152M, 155R, 156N, 159D, 162G, 163F, 164L, 165D, 167D, 168T, 169P, 170V, 171L, 172T, 173K, 180R, 183L, 184V, 185P, 186S, 187R, 191G, 192T, 193F, 194Y, 209I, 210G, 213E, 214K, 220K, 224D, 234E, 244F, 249D, 521F, 524D, 525A, 527K, 528Y, 529G, 530A, 558P, 559F, 561K
CDD
cd00777 (AspRS_core)

149R

homodimer interface
147R, 148H, 149R, 152M, 155R, 156N, 159D, 162G, 163F, 164L, 165D, 167D, 168T, 169P, 170V, 171L, 172T, 173K, 180R, 183L, 184V, 185P, 186S, 187R, 191G, 192T, 193F, 194Y, 209I, 210G, 213E, 214K, 220K, 224D, 234E, 244F, 249D, 521F, 524D, 525A, 527K, 528Y, 529G, 530A, 558P, 559F, 561K
CDD
cd00777 (AspRS_core)

152M

homodimer interface
147R, 148H, 149R, 152M, 155R, 156N, 159D, 162G, 163F, 164L, 165D, 167D, 168T, 169P, 170V, 171L, 172T, 173K, 180R, 183L, 184V, 185P, 186S, 187R, 191G, 192T, 193F, 194Y, 209I, 210G, 213E, 214K, 220K, 224D, 234E, 244F, 249D, 521F, 524D, 525A, 527K, 528Y, 529G, 530A, 558P, 559F, 561K
CDD
cd00777 (AspRS_core)

155R

homodimer interface
147R, 148H, 149R, 152M, 155R, 156N, 159D, 162G, 163F, 164L, 165D, 167D, 168T, 169P, 170V, 171L, 172T, 173K, 180R, 183L, 184V, 185P, 186S, 187R, 191G, 192T, 193F, 194Y, 209I, 210G, 213E, 214K, 220K, 224D, 234E, 244F, 249D, 521F, 524D, 525A, 527K, 528Y, 529G, 530A, 558P, 559F, 561K
CDD
cd00777 (AspRS_core)

156N

homodimer interface
147R, 148H, 149R, 152M, 155R, 156N, 159D, 162G, 163F, 164L, 165D, 167D, 168T, 169P, 170V, 171L, 172T, 173K, 180R, 183L, 184V, 185P, 186S, 187R, 191G, 192T, 193F, 194Y, 209I, 210G, 213E, 214K, 220K, 224D, 234E, 244F, 249D, 521F, 524D, 525A, 527K, 528Y, 529G, 530A, 558P, 559F, 561K
CDD
cd00777 (AspRS_core)

159D

homodimer interface
147R, 148H, 149R, 152M, 155R, 156N, 159D, 162G, 163F, 164L, 165D, 167D, 168T, 169P, 170V, 171L, 172T, 173K, 180R, 183L, 184V, 185P, 186S, 187R, 191G, 192T, 193F, 194Y, 209I, 210G, 213E, 214K, 220K, 224D, 234E, 244F, 249D, 521F, 524D, 525A, 527K, 528Y, 529G, 530A, 558P, 559F, 561K
CDD
cd00777 (AspRS_core)

162G

homodimer interface
147R, 148H, 149R, 152M, 155R, 156N, 159D, 162G, 163F, 164L, 165D, 167D, 168T, 169P, 170V, 171L, 172T, 173K, 180R, 183L, 184V, 185P, 186S, 187R, 191G, 192T, 193F, 194Y, 209I, 210G, 213E, 214K, 220K, 224D, 234E, 244F, 249D, 521F, 524D, 525A, 527K, 528Y, 529G, 530A, 558P, 559F, 561K
CDD
cd00777 (AspRS_core)

163F

homodimer interface
147R, 148H, 149R, 152M, 155R, 156N, 159D, 162G, 163F, 164L, 165D, 167D, 168T, 169P, 170V, 171L, 172T, 173K, 180R, 183L, 184V, 185P, 186S, 187R, 191G, 192T, 193F, 194Y, 209I, 210G, 213E, 214K, 220K, 224D, 234E, 244F, 249D, 521F, 524D, 525A, 527K, 528Y, 529G, 530A, 558P, 559F, 561K
CDD
cd00777 (AspRS_core)

164L

homodimer interface
147R, 148H, 149R, 152M, 155R, 156N, 159D, 162G, 163F, 164L, 165D, 167D, 168T, 169P, 170V, 171L, 172T, 173K, 180R, 183L, 184V, 185P, 186S, 187R, 191G, 192T, 193F, 194Y, 209I, 210G, 213E, 214K, 220K, 224D, 234E, 244F, 249D, 521F, 524D, 525A, 527K, 528Y, 529G, 530A, 558P, 559F, 561K
CDD
cd00777 (AspRS_core)

165D

homodimer interface
147R, 148H, 149R, 152M, 155R, 156N, 159D, 162G, 163F, 164L, 165D, 167D, 168T, 169P, 170V, 171L, 172T, 173K, 180R, 183L, 184V, 185P, 186S, 187R, 191G, 192T, 193F, 194Y, 209I, 210G, 213E, 214K, 220K, 224D, 234E, 244F, 249D, 521F, 524D, 525A, 527K, 528Y, 529G, 530A, 558P, 559F, 561K
CDD
cd00777 (AspRS_core)

167D

homodimer interface
147R, 148H, 149R, 152M, 155R, 156N, 159D, 162G, 163F, 164L, 165D, 167D, 168T, 169P, 170V, 171L, 172T, 173K, 180R, 183L, 184V, 185P, 186S, 187R, 191G, 192T, 193F, 194Y, 209I, 210G, 213E, 214K, 220K, 224D, 234E, 244F, 249D, 521F, 524D, 525A, 527K, 528Y, 529G, 530A, 558P, 559F, 561K
CDD
cd00777 (AspRS_core)

168T

homodimer interface
147R, 148H, 149R, 152M, 155R, 156N, 159D, 162G, 163F, 164L, 165D, 167D, 168T, 169P, 170V, 171L, 172T, 173K, 180R, 183L, 184V, 185P, 186S, 187R, 191G, 192T, 193F, 194Y, 209I, 210G, 213E, 214K, 220K, 224D, 234E, 244F, 249D, 521F, 524D, 525A, 527K, 528Y, 529G, 530A, 558P, 559F, 561K
CDD
cd00777 (AspRS_core)

169P

homodimer interface
147R, 148H, 149R, 152M, 155R, 156N, 159D, 162G, 163F, 164L, 165D, 167D, 168T, 169P, 170V, 171L, 172T, 173K, 180R, 183L, 184V, 185P, 186S, 187R, 191G, 192T, 193F, 194Y, 209I, 210G, 213E, 214K, 220K, 224D, 234E, 244F, 249D, 521F, 524D, 525A, 527K, 528Y, 529G, 530A, 558P, 559F, 561K
CDD
cd00777 (AspRS_core)

170V

homodimer interface
147R, 148H, 149R, 152M, 155R, 156N, 159D, 162G, 163F, 164L, 165D, 167D, 168T, 169P, 170V, 171L, 172T, 173K, 180R, 183L, 184V, 185P, 186S, 187R, 191G, 192T, 193F, 194Y, 209I, 210G, 213E, 214K, 220K, 224D, 234E, 244F, 249D, 521F, 524D, 525A, 527K, 528Y, 529G, 530A, 558P, 559F, 561K
CDD
cd00777 (AspRS_core)

171L

homodimer interface
147R, 148H, 149R, 152M, 155R, 156N, 159D, 162G, 163F, 164L, 165D, 167D, 168T, 169P, 170V, 171L, 172T, 173K, 180R, 183L, 184V, 185P, 186S, 187R, 191G, 192T, 193F, 194Y, 209I, 210G, 213E, 214K, 220K, 224D, 234E, 244F, 249D, 521F, 524D, 525A, 527K, 528Y, 529G, 530A, 558P, 559F, 561K
CDD
cd00777 (AspRS_core)

172T

homodimer interface
147R, 148H, 149R, 152M, 155R, 156N, 159D, 162G, 163F, 164L, 165D, 167D, 168T, 169P, 170V, 171L, 172T, 173K, 180R, 183L, 184V, 185P, 186S, 187R, 191G, 192T, 193F, 194Y, 209I, 210G, 213E, 214K, 220K, 224D, 234E, 244F, 249D, 521F, 524D, 525A, 527K, 528Y, 529G, 530A, 558P, 559F, 561K
CDD
cd00777 (AspRS_core)

173K

homodimer interface
147R, 148H, 149R, 152M, 155R, 156N, 159D, 162G, 163F, 164L, 165D, 167D, 168T, 169P, 170V, 171L, 172T, 173K, 180R, 183L, 184V, 185P, 186S, 187R, 191G, 192T, 193F, 194Y, 209I, 210G, 213E, 214K, 220K, 224D, 234E, 244F, 249D, 521F, 524D, 525A, 527K, 528Y, 529G, 530A, 558P, 559F, 561K
CDD
cd00777 (AspRS_core)

180R

homodimer interface
147R, 148H, 149R, 152M, 155R, 156N, 159D, 162G, 163F, 164L, 165D, 167D, 168T, 169P, 170V, 171L, 172T, 173K, 180R, 183L, 184V, 185P, 186S, 187R, 191G, 192T, 193F, 194Y, 209I, 210G, 213E, 214K, 220K, 224D, 234E, 244F, 249D, 521F, 524D, 525A, 527K, 528Y, 529G, 530A, 558P, 559F, 561K
CDD
cd00777 (AspRS_core)

183L

homodimer interface
147R, 148H, 149R, 152M, 155R, 156N, 159D, 162G, 163F, 164L, 165D, 167D, 168T, 169P, 170V, 171L, 172T, 173K, 180R, 183L, 184V, 185P, 186S, 187R, 191G, 192T, 193F, 194Y, 209I, 210G, 213E, 214K, 220K, 224D, 234E, 244F, 249D, 521F, 524D, 525A, 527K, 528Y, 529G, 530A, 558P, 559F, 561K
CDD
cd00777 (AspRS_core)

184V

homodimer interface
147R, 148H, 149R, 152M, 155R, 156N, 159D, 162G, 163F, 164L, 165D, 167D, 168T, 169P, 170V, 171L, 172T, 173K, 180R, 183L, 184V, 185P, 186S, 187R, 191G, 192T, 193F, 194Y, 209I, 210G, 213E, 214K, 220K, 224D, 234E, 244F, 249D, 521F, 524D, 525A, 527K, 528Y, 529G, 530A, 558P, 559F, 561K
CDD
cd00777 (AspRS_core)

185P

homodimer interface
147R, 148H, 149R, 152M, 155R, 156N, 159D, 162G, 163F, 164L, 165D, 167D, 168T, 169P, 170V, 171L, 172T, 173K, 180R, 183L, 184V, 185P, 186S, 187R, 191G, 192T, 193F, 194Y, 209I, 210G, 213E, 214K, 220K, 224D, 234E, 244F, 249D, 521F, 524D, 525A, 527K, 528Y, 529G, 530A, 558P, 559F, 561K
CDD
cd00777 (AspRS_core)

186S

homodimer interface
147R, 148H, 149R, 152M, 155R, 156N, 159D, 162G, 163F, 164L, 165D, 167D, 168T, 169P, 170V, 171L, 172T, 173K, 180R, 183L, 184V, 185P, 186S, 187R, 191G, 192T, 193F, 194Y, 209I, 210G, 213E, 214K, 220K, 224D, 234E, 244F, 249D, 521F, 524D, 525A, 527K, 528Y, 529G, 530A, 558P, 559F, 561K
CDD
cd00777 (AspRS_core)

187R

homodimer interface
147R, 148H, 149R, 152M, 155R, 156N, 159D, 162G, 163F, 164L, 165D, 167D, 168T, 169P, 170V, 171L, 172T, 173K, 180R, 183L, 184V, 185P, 186S, 187R, 191G, 192T, 193F, 194Y, 209I, 210G, 213E, 214K, 220K, 224D, 234E, 244F, 249D, 521F, 524D, 525A, 527K, 528Y, 529G, 530A, 558P, 559F, 561K
CDD
cd00777 (AspRS_core)

191G

homodimer interface
147R, 148H, 149R, 152M, 155R, 156N, 159D, 162G, 163F, 164L, 165D, 167D, 168T, 169P, 170V, 171L, 172T, 173K, 180R, 183L, 184V, 185P, 186S, 187R, 191G, 192T, 193F, 194Y, 209I, 210G, 213E, 214K, 220K, 224D, 234E, 244F, 249D, 521F, 524D, 525A, 527K, 528Y, 529G, 530A, 558P, 559F, 561K
CDD
cd00777 (AspRS_core)

192T

homodimer interface
147R, 148H, 149R, 152M, 155R, 156N, 159D, 162G, 163F, 164L, 165D, 167D, 168T, 169P, 170V, 171L, 172T, 173K, 180R, 183L, 184V, 185P, 186S, 187R, 191G, 192T, 193F, 194Y, 209I, 210G, 213E, 214K, 220K, 224D, 234E, 244F, 249D, 521F, 524D, 525A, 527K, 528Y, 529G, 530A, 558P, 559F, 561K
CDD
cd00777 (AspRS_core)

193F

homodimer interface
147R, 148H, 149R, 152M, 155R, 156N, 159D, 162G, 163F, 164L, 165D, 167D, 168T, 169P, 170V, 171L, 172T, 173K, 180R, 183L, 184V, 185P, 186S, 187R, 191G, 192T, 193F, 194Y, 209I, 210G, 213E, 214K, 220K, 224D, 234E, 244F, 249D, 521F, 524D, 525A, 527K, 528Y, 529G, 530A, 558P, 559F, 561K
CDD
cd00777 (AspRS_core)

194Y

homodimer interface
147R, 148H, 149R, 152M, 155R, 156N, 159D, 162G, 163F, 164L, 165D, 167D, 168T, 169P, 170V, 171L, 172T, 173K, 180R, 183L, 184V, 185P, 186S, 187R, 191G, 192T, 193F, 194Y, 209I, 210G, 213E, 214K, 220K, 224D, 234E, 244F, 249D, 521F, 524D, 525A, 527K, 528Y, 529G, 530A, 558P, 559F, 561K
CDD
cd00777 (AspRS_core)

209I

homodimer interface
147R, 148H, 149R, 152M, 155R, 156N, 159D, 162G, 163F, 164L, 165D, 167D, 168T, 169P, 170V, 171L, 172T, 173K, 180R, 183L, 184V, 185P, 186S, 187R, 191G, 192T, 193F, 194Y, 209I, 210G, 213E, 214K, 220K, 224D, 234E, 244F, 249D, 521F, 524D, 525A, 527K, 528Y, 529G, 530A, 558P, 559F, 561K
CDD
cd00777 (AspRS_core)

210G

homodimer interface
147R, 148H, 149R, 152M, 155R, 156N, 159D, 162G, 163F, 164L, 165D, 167D, 168T, 169P, 170V, 171L, 172T, 173K, 180R, 183L, 184V, 185P, 186S, 187R, 191G, 192T, 193F, 194Y, 209I, 210G, 213E, 214K, 220K, 224D, 234E, 244F, 249D, 521F, 524D, 525A, 527K, 528Y, 529G, 530A, 558P, 559F, 561K
CDD
cd00777 (AspRS_core)

213E

homodimer interface
147R, 148H, 149R, 152M, 155R, 156N, 159D, 162G, 163F, 164L, 165D, 167D, 168T, 169P, 170V, 171L, 172T, 173K, 180R, 183L, 184V, 185P, 186S, 187R, 191G, 192T, 193F, 194Y, 209I, 210G, 213E, 214K, 220K, 224D, 234E, 244F, 249D, 521F, 524D, 525A, 527K, 528Y, 529G, 530A, 558P, 559F, 561K
CDD
cd00777 (AspRS_core)

214K

homodimer interface
147R, 148H, 149R, 152M, 155R, 156N, 159D, 162G, 163F, 164L, 165D, 167D, 168T, 169P, 170V, 171L, 172T, 173K, 180R, 183L, 184V, 185P, 186S, 187R, 191G, 192T, 193F, 194Y, 209I, 210G, 213E, 214K, 220K, 224D, 234E, 244F, 249D, 521F, 524D, 525A, 527K, 528Y, 529G, 530A, 558P, 559F, 561K
CDD
cd00777 (AspRS_core)

220K

homodimer interface
147R, 148H, 149R, 152M, 155R, 156N, 159D, 162G, 163F, 164L, 165D, 167D, 168T, 169P, 170V, 171L, 172T, 173K, 180R, 183L, 184V, 185P, 186S, 187R, 191G, 192T, 193F, 194Y, 209I, 210G, 213E, 214K, 220K, 224D, 234E, 244F, 249D, 521F, 524D, 525A, 527K, 528Y, 529G, 530A, 558P, 559F, 561K
CDD
cd00777 (AspRS_core)

224D

homodimer interface
147R, 148H, 149R, 152M, 155R, 156N, 159D, 162G, 163F, 164L, 165D, 167D, 168T, 169P, 170V, 171L, 172T, 173K, 180R, 183L, 184V, 185P, 186S, 187R, 191G, 192T, 193F, 194Y, 209I, 210G, 213E, 214K, 220K, 224D, 234E, 244F, 249D, 521F, 524D, 525A, 527K, 528Y, 529G, 530A, 558P, 559F, 561K
CDD
cd00777 (AspRS_core)

234E

homodimer interface
147R, 148H, 149R, 152M, 155R, 156N, 159D, 162G, 163F, 164L, 165D, 167D, 168T, 169P, 170V, 171L, 172T, 173K, 180R, 183L, 184V, 185P, 186S, 187R, 191G, 192T, 193F, 194Y, 209I, 210G, 213E, 214K, 220K, 224D, 234E, 244F, 249D, 521F, 524D, 525A, 527K, 528Y, 529G, 530A, 558P, 559F, 561K
CDD
cd00777 (AspRS_core)

244F

homodimer interface
147R, 148H, 149R, 152M, 155R, 156N, 159D, 162G, 163F, 164L, 165D, 167D, 168T, 169P, 170V, 171L, 172T, 173K, 180R, 183L, 184V, 185P, 186S, 187R, 191G, 192T, 193F, 194Y, 209I, 210G, 213E, 214K, 220K, 224D, 234E, 244F, 249D, 521F, 524D, 525A, 527K, 528Y, 529G, 530A, 558P, 559F, 561K
CDD
cd00777 (AspRS_core)

249D

homodimer interface
147R, 148H, 149R, 152M, 155R, 156N, 159D, 162G, 163F, 164L, 165D, 167D, 168T, 169P, 170V, 171L, 172T, 173K, 180R, 183L, 184V, 185P, 186S, 187R, 191G, 192T, 193F, 194Y, 209I, 210G, 213E, 214K, 220K, 224D, 234E, 244F, 249D, 521F, 524D, 525A, 527K, 528Y, 529G, 530A, 558P, 559F, 561K
CDD
cd00777 (AspRS_core)

521F

homodimer interface
147R, 148H, 149R, 152M, 155R, 156N, 159D, 162G, 163F, 164L, 165D, 167D, 168T, 169P, 170V, 171L, 172T, 173K, 180R, 183L, 184V, 185P, 186S, 187R, 191G, 192T, 193F, 194Y, 209I, 210G, 213E, 214K, 220K, 224D, 234E, 244F, 249D, 521F, 524D, 525A, 527K, 528Y, 529G, 530A, 558P, 559F, 561K
CDD
cd00777 (AspRS_core)

524D

homodimer interface
147R, 148H, 149R, 152M, 155R, 156N, 159D, 162G, 163F, 164L, 165D, 167D, 168T, 169P, 170V, 171L, 172T, 173K, 180R, 183L, 184V, 185P, 186S, 187R, 191G, 192T, 193F, 194Y, 209I, 210G, 213E, 214K, 220K, 224D, 234E, 244F, 249D, 521F, 524D, 525A, 527K, 528Y, 529G, 530A, 558P, 559F, 561K
CDD
cd00777 (AspRS_core)

525A

homodimer interface
147R, 148H, 149R, 152M, 155R, 156N, 159D, 162G, 163F, 164L, 165D, 167D, 168T, 169P, 170V, 171L, 172T, 173K, 180R, 183L, 184V, 185P, 186S, 187R, 191G, 192T, 193F, 194Y, 209I, 210G, 213E, 214K, 220K, 224D, 234E, 244F, 249D, 521F, 524D, 525A, 527K, 528Y, 529G, 530A, 558P, 559F, 561K
CDD
cd00777 (AspRS_core)

527K

homodimer interface
147R, 148H, 149R, 152M, 155R, 156N, 159D, 162G, 163F, 164L, 165D, 167D, 168T, 169P, 170V, 171L, 172T, 173K, 180R, 183L, 184V, 185P, 186S, 187R, 191G, 192T, 193F, 194Y, 209I, 210G, 213E, 214K, 220K, 224D, 234E, 244F, 249D, 521F, 524D, 525A, 527K, 528Y, 529G, 530A, 558P, 559F, 561K
CDD
cd00777 (AspRS_core)

528Y

homodimer interface
147R, 148H, 149R, 152M, 155R, 156N, 159D, 162G, 163F, 164L, 165D, 167D, 168T, 169P, 170V, 171L, 172T, 173K, 180R, 183L, 184V, 185P, 186S, 187R, 191G, 192T, 193F, 194Y, 209I, 210G, 213E, 214K, 220K, 224D, 234E, 244F, 249D, 521F, 524D, 525A, 527K, 528Y, 529G, 530A, 558P, 559F, 561K
CDD
cd00777 (AspRS_core)

529G

homodimer interface
147R, 148H, 149R, 152M, 155R, 156N, 159D, 162G, 163F, 164L, 165D, 167D, 168T, 169P, 170V, 171L, 172T, 173K, 180R, 183L, 184V, 185P, 186S, 187R, 191G, 192T, 193F, 194Y, 209I, 210G, 213E, 214K, 220K, 224D, 234E, 244F, 249D, 521F, 524D, 525A, 527K, 528Y, 529G, 530A, 558P, 559F, 561K
CDD
cd00777 (AspRS_core)

530A

homodimer interface
147R, 148H, 149R, 152M, 155R, 156N, 159D, 162G, 163F, 164L, 165D, 167D, 168T, 169P, 170V, 171L, 172T, 173K, 180R, 183L, 184V, 185P, 186S, 187R, 191G, 192T, 193F, 194Y, 209I, 210G, 213E, 214K, 220K, 224D, 234E, 244F, 249D, 521F, 524D, 525A, 527K, 528Y, 529G, 530A, 558P, 559F, 561K
CDD
cd00777 (AspRS_core)

558P

homodimer interface
147R, 148H, 149R, 152M, 155R, 156N, 159D, 162G, 163F, 164L, 165D, 167D, 168T, 169P, 170V, 171L, 172T, 173K, 180R, 183L, 184V, 185P, 186S, 187R, 191G, 192T, 193F, 194Y, 209I, 210G, 213E, 214K, 220K, 224D, 234E, 244F, 249D, 521F, 524D, 525A, 527K, 528Y, 529G, 530A, 558P, 559F, 561K
CDD
cd00777 (AspRS_core)

559F

homodimer interface
147R, 148H, 149R, 152M, 155R, 156N, 159D, 162G, 163F, 164L, 165D, 167D, 168T, 169P, 170V, 171L, 172T, 173K, 180R, 183L, 184V, 185P, 186S, 187R, 191G, 192T, 193F, 194Y, 209I, 210G, 213E, 214K, 220K, 224D, 234E, 244F, 249D, 521F, 524D, 525A, 527K, 528Y, 529G, 530A, 558P, 559F, 561K
CDD
cd00777 (AspRS_core)

561K

homodimer interface
147R, 148H, 149R, 152M, 155R, 156N, 159D, 162G, 163F, 164L, 165D, 167D, 168T, 169P, 170V, 171L, 172T, 173K, 180R, 183L, 184V, 185P, 186S, 187R, 191G, 192T, 193F, 194Y, 209I, 210G, 213E, 214K, 220K, 224D, 234E, 244F, 249D, 521F, 524D, 525A, 527K, 528Y, 529G, 530A, 558P, 559F, 561K
CDD
cd00777 (AspRS_core)
motif 1 cd00777

169P

motif 1
169P, 170V, 171L, 172T, 173K
CDD
cd00777 (AspRS_core)

170V

motif 1
169P, 170V, 171L, 172T, 173K
CDD
cd00777 (AspRS_core)

171L

motif 1
169P, 170V, 171L, 172T, 173K
CDD
cd00777 (AspRS_core)

172T

motif 1
169P, 170V, 171L, 172T, 173K
CDD
cd00777 (AspRS_core)

173K

motif 1
169P, 170V, 171L, 172T, 173K
CDD
cd00777 (AspRS_core)
active site cd00777

177E

active site
177E, 178G, 179A, 199S, 201Q, 204K, 223R, 225E, 230D, 231R, 232Q, 235F, 237Q, 452H, 453H, 487E, 490G, 494R, 536L, 537A, 539G, 542R
CDD
cd00777 (AspRS_core)

178G

active site
177E, 178G, 179A, 199S, 201Q, 204K, 223R, 225E, 230D, 231R, 232Q, 235F, 237Q, 452H, 453H, 487E, 490G, 494R, 536L, 537A, 539G, 542R
CDD
cd00777 (AspRS_core)

179A

active site
177E, 178G, 179A, 199S, 201Q, 204K, 223R, 225E, 230D, 231R, 232Q, 235F, 237Q, 452H, 453H, 487E, 490G, 494R, 536L, 537A, 539G, 542R
CDD
cd00777 (AspRS_core)

199S

active site
177E, 178G, 179A, 199S, 201Q, 204K, 223R, 225E, 230D, 231R, 232Q, 235F, 237Q, 452H, 453H, 487E, 490G, 494R, 536L, 537A, 539G, 542R
CDD
cd00777 (AspRS_core)

201Q

active site
177E, 178G, 179A, 199S, 201Q, 204K, 223R, 225E, 230D, 231R, 232Q, 235F, 237Q, 452H, 453H, 487E, 490G, 494R, 536L, 537A, 539G, 542R
CDD
cd00777 (AspRS_core)

204K

active site
177E, 178G, 179A, 199S, 201Q, 204K, 223R, 225E, 230D, 231R, 232Q, 235F, 237Q, 452H, 453H, 487E, 490G, 494R, 536L, 537A, 539G, 542R
CDD
cd00777 (AspRS_core)

223R

active site
177E, 178G, 179A, 199S, 201Q, 204K, 223R, 225E, 230D, 231R, 232Q, 235F, 237Q, 452H, 453H, 487E, 490G, 494R, 536L, 537A, 539G, 542R
CDD
cd00777 (AspRS_core)

225E

active site
177E, 178G, 179A, 199S, 201Q, 204K, 223R, 225E, 230D, 231R, 232Q, 235F, 237Q, 452H, 453H, 487E, 490G, 494R, 536L, 537A, 539G, 542R
CDD
cd00777 (AspRS_core)

230D

active site
177E, 178G, 179A, 199S, 201Q, 204K, 223R, 225E, 230D, 231R, 232Q, 235F, 237Q, 452H, 453H, 487E, 490G, 494R, 536L, 537A, 539G, 542R
CDD
cd00777 (AspRS_core)

231R

active site
177E, 178G, 179A, 199S, 201Q, 204K, 223R, 225E, 230D, 231R, 232Q, 235F, 237Q, 452H, 453H, 487E, 490G, 494R, 536L, 537A, 539G, 542R
CDD
cd00777 (AspRS_core)

232Q

active site
177E, 178G, 179A, 199S, 201Q, 204K, 223R, 225E, 230D, 231R, 232Q, 235F, 237Q, 452H, 453H, 487E, 490G, 494R, 536L, 537A, 539G, 542R
CDD
cd00777 (AspRS_core)

235F

active site
177E, 178G, 179A, 199S, 201Q, 204K, 223R, 225E, 230D, 231R, 232Q, 235F, 237Q, 452H, 453H, 487E, 490G, 494R, 536L, 537A, 539G, 542R
CDD
cd00777 (AspRS_core)

237Q

active site
177E, 178G, 179A, 199S, 201Q, 204K, 223R, 225E, 230D, 231R, 232Q, 235F, 237Q, 452H, 453H, 487E, 490G, 494R, 536L, 537A, 539G, 542R
CDD
cd00777 (AspRS_core)

452H

active site
177E, 178G, 179A, 199S, 201Q, 204K, 223R, 225E, 230D, 231R, 232Q, 235F, 237Q, 452H, 453H, 487E, 490G, 494R, 536L, 537A, 539G, 542R
CDD
cd00777 (AspRS_core)

453H

active site
177E, 178G, 179A, 199S, 201Q, 204K, 223R, 225E, 230D, 231R, 232Q, 235F, 237Q, 452H, 453H, 487E, 490G, 494R, 536L, 537A, 539G, 542R
CDD
cd00777 (AspRS_core)

487E

active site
177E, 178G, 179A, 199S, 201Q, 204K, 223R, 225E, 230D, 231R, 232Q, 235F, 237Q, 452H, 453H, 487E, 490G, 494R, 536L, 537A, 539G, 542R
CDD
cd00777 (AspRS_core)

490G

active site
177E, 178G, 179A, 199S, 201Q, 204K, 223R, 225E, 230D, 231R, 232Q, 235F, 237Q, 452H, 453H, 487E, 490G, 494R, 536L, 537A, 539G, 542R
CDD
cd00777 (AspRS_core)

494R

active site
177E, 178G, 179A, 199S, 201Q, 204K, 223R, 225E, 230D, 231R, 232Q, 235F, 237Q, 452H, 453H, 487E, 490G, 494R, 536L, 537A, 539G, 542R
CDD
cd00777 (AspRS_core)

536L

active site
177E, 178G, 179A, 199S, 201Q, 204K, 223R, 225E, 230D, 231R, 232Q, 235F, 237Q, 452H, 453H, 487E, 490G, 494R, 536L, 537A, 539G, 542R
CDD
cd00777 (AspRS_core)

537A

active site
177E, 178G, 179A, 199S, 201Q, 204K, 223R, 225E, 230D, 231R, 232Q, 235F, 237Q, 452H, 453H, 487E, 490G, 494R, 536L, 537A, 539G, 542R
CDD
cd00777 (AspRS_core)

539G

active site
177E, 178G, 179A, 199S, 201Q, 204K, 223R, 225E, 230D, 231R, 232Q, 235F, 237Q, 452H, 453H, 487E, 490G, 494R, 536L, 537A, 539G, 542R
CDD
cd00777 (AspRS_core)

542R

active site
177E, 178G, 179A, 199S, 201Q, 204K, 223R, 225E, 230D, 231R, 232Q, 235F, 237Q, 452H, 453H, 487E, 490G, 494R, 536L, 537A, 539G, 542R
CDD
cd00777 (AspRS_core)
motif 2 cd00777

222F

motif 2
222F, 223R, 224D, 225E
CDD
cd00777 (AspRS_core)

223R

motif 2
222F, 223R, 224D, 225E
CDD
cd00777 (AspRS_core)

224D

motif 2
222F, 223R, 224D, 225E
CDD
cd00777 (AspRS_core)

225E

motif 2
222F, 223R, 224D, 225E
CDD
cd00777 (AspRS_core)
motif 3 cd00777

539G

motif 3
539G, 540I, 541D, 542R
CDD
cd00777 (AspRS_core)

540I

motif 3
539G, 540I, 541D, 542R
CDD
cd00777 (AspRS_core)

541D

motif 3
539G, 540I, 541D, 542R
CDD
cd00777 (AspRS_core)

542R

motif 3
539G, 540I, 541D, 542R
CDD
cd00777 (AspRS_core)

GO term prediction

Biological Process

GO:0006418 tRNA aminoacylation for protein translation

Molecular Function

GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0005524 ATP binding
GO:0016874 ligase activity

Cellular Component

GO:0005737 cytoplasm

Filter view on

Entry type

Status

Per-residue features

25586_FusoPortal_Gene_855

Protein family membership

Homologous superfamilies

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component