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Protein

27725_FusoPortal_Gene_1136

Length

207 amino acids

Protein family membership

GrpE nucleotide exchange factor (IPR000740)

Homologous superfamilies

Homologous superfamily
47 - 148
GrpE nucleotide exchange factor, coiled-coil (IPR013805)
150 - 205
GrpE nucleotide exchange factor, head (IPR009012)

1 20 40 60 80 100 120 140 160 180 207

Domains and repeats

None predicted.

Detailed signature matches

IPR013805

GrpE nucleotide exchange factor, coiled-coil

G3DSA:3.90.20.20

47 - 148

GENE3D
G3DSA:3.90.20.20 (G3DSA:3.90.20.20)

IPR009012

GrpE nucleotide exchange factor, head

SSF51064 (Head doma...)

156 - 205

SUPERFAMILY
SSF51064 (Head domain of nucleotide exchange factor GrpE)
G3DSA:2.30.22.10

150 - 205

GENE3D
G3DSA:2.30.22.10 (G3DSA:2.30.22.10)

IPR000740

GrpE nucleotide exchange factor

MF_01151 (GrpE)

3 - 205

HAMAP
MF_01151 (GrpE)
PR00773 (GRPEPROTEIN)

76 - 92

PRINTS
PR00773 (GRPEPROTEIN)

157 - 172

PRINTS
PR00773 (GRPEPROTEIN)

104 - 119

PRINTS
PR00773 (GRPEPROTEIN)

184 - 203

PRINTS
PR00773 (GRPEPROTEIN)
PS01071 (GRPE)

160 - 203

PROSITE patterns
PS01071 (GRPE)
PTHR21237 (GRPE PRO...)

26 - 204

PANTHER
PTHR21237 (GRPE PROTEIN)
cd00446 (GrpE)

69 - 203

CDD
cd00446 (GrpE)
PF01025 (GrpE)

54 - 205

Pfam
PF01025 (GrpE)

no IPR

Unintegrated signatures

Coil

54 - 74

COILS
Coil (Coil)

14 - 34

COILS
Coil (Coil)
SSF58014 (Coiled-co...)

56 - 150

SUPERFAMILY
SSF58014 (Coiled-coil domain of nucleotide exchange factor GrpE)

Residue annotation

dimer interface cd...

71W

dimer interface
71W, 74S, 75Y, 78K, 79Q, 81D, 82F, 85F, 86T, 87K, 89K, 92E, 93V, 96L, 97R, 100A, 101S, 103K, 104I, 107K, 108L, 109L, 111G, 112L, 113D, 114N, 115L, 117R, 118A, 134G, 135V, 137M, 138I, 139L, 142L, 148N, 149E
CDD
cd00446 (GrpE)

74S

dimer interface
71W, 74S, 75Y, 78K, 79Q, 81D, 82F, 85F, 86T, 87K, 89K, 92E, 93V, 96L, 97R, 100A, 101S, 103K, 104I, 107K, 108L, 109L, 111G, 112L, 113D, 114N, 115L, 117R, 118A, 134G, 135V, 137M, 138I, 139L, 142L, 148N, 149E
CDD
cd00446 (GrpE)

75Y

dimer interface
71W, 74S, 75Y, 78K, 79Q, 81D, 82F, 85F, 86T, 87K, 89K, 92E, 93V, 96L, 97R, 100A, 101S, 103K, 104I, 107K, 108L, 109L, 111G, 112L, 113D, 114N, 115L, 117R, 118A, 134G, 135V, 137M, 138I, 139L, 142L, 148N, 149E
CDD
cd00446 (GrpE)

78K

dimer interface
71W, 74S, 75Y, 78K, 79Q, 81D, 82F, 85F, 86T, 87K, 89K, 92E, 93V, 96L, 97R, 100A, 101S, 103K, 104I, 107K, 108L, 109L, 111G, 112L, 113D, 114N, 115L, 117R, 118A, 134G, 135V, 137M, 138I, 139L, 142L, 148N, 149E
CDD
cd00446 (GrpE)

79Q

dimer interface
71W, 74S, 75Y, 78K, 79Q, 81D, 82F, 85F, 86T, 87K, 89K, 92E, 93V, 96L, 97R, 100A, 101S, 103K, 104I, 107K, 108L, 109L, 111G, 112L, 113D, 114N, 115L, 117R, 118A, 134G, 135V, 137M, 138I, 139L, 142L, 148N, 149E
CDD
cd00446 (GrpE)

81D

dimer interface
71W, 74S, 75Y, 78K, 79Q, 81D, 82F, 85F, 86T, 87K, 89K, 92E, 93V, 96L, 97R, 100A, 101S, 103K, 104I, 107K, 108L, 109L, 111G, 112L, 113D, 114N, 115L, 117R, 118A, 134G, 135V, 137M, 138I, 139L, 142L, 148N, 149E
CDD
cd00446 (GrpE)

82F

dimer interface
71W, 74S, 75Y, 78K, 79Q, 81D, 82F, 85F, 86T, 87K, 89K, 92E, 93V, 96L, 97R, 100A, 101S, 103K, 104I, 107K, 108L, 109L, 111G, 112L, 113D, 114N, 115L, 117R, 118A, 134G, 135V, 137M, 138I, 139L, 142L, 148N, 149E
CDD
cd00446 (GrpE)

85F

dimer interface
71W, 74S, 75Y, 78K, 79Q, 81D, 82F, 85F, 86T, 87K, 89K, 92E, 93V, 96L, 97R, 100A, 101S, 103K, 104I, 107K, 108L, 109L, 111G, 112L, 113D, 114N, 115L, 117R, 118A, 134G, 135V, 137M, 138I, 139L, 142L, 148N, 149E
CDD
cd00446 (GrpE)

86T

dimer interface
71W, 74S, 75Y, 78K, 79Q, 81D, 82F, 85F, 86T, 87K, 89K, 92E, 93V, 96L, 97R, 100A, 101S, 103K, 104I, 107K, 108L, 109L, 111G, 112L, 113D, 114N, 115L, 117R, 118A, 134G, 135V, 137M, 138I, 139L, 142L, 148N, 149E
CDD
cd00446 (GrpE)

87K

dimer interface
71W, 74S, 75Y, 78K, 79Q, 81D, 82F, 85F, 86T, 87K, 89K, 92E, 93V, 96L, 97R, 100A, 101S, 103K, 104I, 107K, 108L, 109L, 111G, 112L, 113D, 114N, 115L, 117R, 118A, 134G, 135V, 137M, 138I, 139L, 142L, 148N, 149E
CDD
cd00446 (GrpE)

89K

dimer interface
71W, 74S, 75Y, 78K, 79Q, 81D, 82F, 85F, 86T, 87K, 89K, 92E, 93V, 96L, 97R, 100A, 101S, 103K, 104I, 107K, 108L, 109L, 111G, 112L, 113D, 114N, 115L, 117R, 118A, 134G, 135V, 137M, 138I, 139L, 142L, 148N, 149E
CDD
cd00446 (GrpE)

92E

dimer interface
71W, 74S, 75Y, 78K, 79Q, 81D, 82F, 85F, 86T, 87K, 89K, 92E, 93V, 96L, 97R, 100A, 101S, 103K, 104I, 107K, 108L, 109L, 111G, 112L, 113D, 114N, 115L, 117R, 118A, 134G, 135V, 137M, 138I, 139L, 142L, 148N, 149E
CDD
cd00446 (GrpE)

93V

dimer interface
71W, 74S, 75Y, 78K, 79Q, 81D, 82F, 85F, 86T, 87K, 89K, 92E, 93V, 96L, 97R, 100A, 101S, 103K, 104I, 107K, 108L, 109L, 111G, 112L, 113D, 114N, 115L, 117R, 118A, 134G, 135V, 137M, 138I, 139L, 142L, 148N, 149E
CDD
cd00446 (GrpE)

96L

dimer interface
71W, 74S, 75Y, 78K, 79Q, 81D, 82F, 85F, 86T, 87K, 89K, 92E, 93V, 96L, 97R, 100A, 101S, 103K, 104I, 107K, 108L, 109L, 111G, 112L, 113D, 114N, 115L, 117R, 118A, 134G, 135V, 137M, 138I, 139L, 142L, 148N, 149E
CDD
cd00446 (GrpE)

97R

dimer interface
71W, 74S, 75Y, 78K, 79Q, 81D, 82F, 85F, 86T, 87K, 89K, 92E, 93V, 96L, 97R, 100A, 101S, 103K, 104I, 107K, 108L, 109L, 111G, 112L, 113D, 114N, 115L, 117R, 118A, 134G, 135V, 137M, 138I, 139L, 142L, 148N, 149E
CDD
cd00446 (GrpE)

100A

dimer interface
71W, 74S, 75Y, 78K, 79Q, 81D, 82F, 85F, 86T, 87K, 89K, 92E, 93V, 96L, 97R, 100A, 101S, 103K, 104I, 107K, 108L, 109L, 111G, 112L, 113D, 114N, 115L, 117R, 118A, 134G, 135V, 137M, 138I, 139L, 142L, 148N, 149E
CDD
cd00446 (GrpE)

101S

dimer interface
71W, 74S, 75Y, 78K, 79Q, 81D, 82F, 85F, 86T, 87K, 89K, 92E, 93V, 96L, 97R, 100A, 101S, 103K, 104I, 107K, 108L, 109L, 111G, 112L, 113D, 114N, 115L, 117R, 118A, 134G, 135V, 137M, 138I, 139L, 142L, 148N, 149E
CDD
cd00446 (GrpE)

103K

dimer interface
71W, 74S, 75Y, 78K, 79Q, 81D, 82F, 85F, 86T, 87K, 89K, 92E, 93V, 96L, 97R, 100A, 101S, 103K, 104I, 107K, 108L, 109L, 111G, 112L, 113D, 114N, 115L, 117R, 118A, 134G, 135V, 137M, 138I, 139L, 142L, 148N, 149E
CDD
cd00446 (GrpE)

104I

dimer interface
71W, 74S, 75Y, 78K, 79Q, 81D, 82F, 85F, 86T, 87K, 89K, 92E, 93V, 96L, 97R, 100A, 101S, 103K, 104I, 107K, 108L, 109L, 111G, 112L, 113D, 114N, 115L, 117R, 118A, 134G, 135V, 137M, 138I, 139L, 142L, 148N, 149E
CDD
cd00446 (GrpE)

107K

dimer interface
71W, 74S, 75Y, 78K, 79Q, 81D, 82F, 85F, 86T, 87K, 89K, 92E, 93V, 96L, 97R, 100A, 101S, 103K, 104I, 107K, 108L, 109L, 111G, 112L, 113D, 114N, 115L, 117R, 118A, 134G, 135V, 137M, 138I, 139L, 142L, 148N, 149E
CDD
cd00446 (GrpE)

108L

dimer interface
71W, 74S, 75Y, 78K, 79Q, 81D, 82F, 85F, 86T, 87K, 89K, 92E, 93V, 96L, 97R, 100A, 101S, 103K, 104I, 107K, 108L, 109L, 111G, 112L, 113D, 114N, 115L, 117R, 118A, 134G, 135V, 137M, 138I, 139L, 142L, 148N, 149E
CDD
cd00446 (GrpE)

109L

dimer interface
71W, 74S, 75Y, 78K, 79Q, 81D, 82F, 85F, 86T, 87K, 89K, 92E, 93V, 96L, 97R, 100A, 101S, 103K, 104I, 107K, 108L, 109L, 111G, 112L, 113D, 114N, 115L, 117R, 118A, 134G, 135V, 137M, 138I, 139L, 142L, 148N, 149E
CDD
cd00446 (GrpE)

111G

dimer interface
71W, 74S, 75Y, 78K, 79Q, 81D, 82F, 85F, 86T, 87K, 89K, 92E, 93V, 96L, 97R, 100A, 101S, 103K, 104I, 107K, 108L, 109L, 111G, 112L, 113D, 114N, 115L, 117R, 118A, 134G, 135V, 137M, 138I, 139L, 142L, 148N, 149E
CDD
cd00446 (GrpE)

112L

dimer interface
71W, 74S, 75Y, 78K, 79Q, 81D, 82F, 85F, 86T, 87K, 89K, 92E, 93V, 96L, 97R, 100A, 101S, 103K, 104I, 107K, 108L, 109L, 111G, 112L, 113D, 114N, 115L, 117R, 118A, 134G, 135V, 137M, 138I, 139L, 142L, 148N, 149E
CDD
cd00446 (GrpE)

113D

dimer interface
71W, 74S, 75Y, 78K, 79Q, 81D, 82F, 85F, 86T, 87K, 89K, 92E, 93V, 96L, 97R, 100A, 101S, 103K, 104I, 107K, 108L, 109L, 111G, 112L, 113D, 114N, 115L, 117R, 118A, 134G, 135V, 137M, 138I, 139L, 142L, 148N, 149E
CDD
cd00446 (GrpE)

114N

dimer interface
71W, 74S, 75Y, 78K, 79Q, 81D, 82F, 85F, 86T, 87K, 89K, 92E, 93V, 96L, 97R, 100A, 101S, 103K, 104I, 107K, 108L, 109L, 111G, 112L, 113D, 114N, 115L, 117R, 118A, 134G, 135V, 137M, 138I, 139L, 142L, 148N, 149E
CDD
cd00446 (GrpE)

115L

dimer interface
71W, 74S, 75Y, 78K, 79Q, 81D, 82F, 85F, 86T, 87K, 89K, 92E, 93V, 96L, 97R, 100A, 101S, 103K, 104I, 107K, 108L, 109L, 111G, 112L, 113D, 114N, 115L, 117R, 118A, 134G, 135V, 137M, 138I, 139L, 142L, 148N, 149E
CDD
cd00446 (GrpE)

117R

dimer interface
71W, 74S, 75Y, 78K, 79Q, 81D, 82F, 85F, 86T, 87K, 89K, 92E, 93V, 96L, 97R, 100A, 101S, 103K, 104I, 107K, 108L, 109L, 111G, 112L, 113D, 114N, 115L, 117R, 118A, 134G, 135V, 137M, 138I, 139L, 142L, 148N, 149E
CDD
cd00446 (GrpE)

118A

dimer interface
71W, 74S, 75Y, 78K, 79Q, 81D, 82F, 85F, 86T, 87K, 89K, 92E, 93V, 96L, 97R, 100A, 101S, 103K, 104I, 107K, 108L, 109L, 111G, 112L, 113D, 114N, 115L, 117R, 118A, 134G, 135V, 137M, 138I, 139L, 142L, 148N, 149E
CDD
cd00446 (GrpE)

134G

dimer interface
71W, 74S, 75Y, 78K, 79Q, 81D, 82F, 85F, 86T, 87K, 89K, 92E, 93V, 96L, 97R, 100A, 101S, 103K, 104I, 107K, 108L, 109L, 111G, 112L, 113D, 114N, 115L, 117R, 118A, 134G, 135V, 137M, 138I, 139L, 142L, 148N, 149E
CDD
cd00446 (GrpE)

135V

dimer interface
71W, 74S, 75Y, 78K, 79Q, 81D, 82F, 85F, 86T, 87K, 89K, 92E, 93V, 96L, 97R, 100A, 101S, 103K, 104I, 107K, 108L, 109L, 111G, 112L, 113D, 114N, 115L, 117R, 118A, 134G, 135V, 137M, 138I, 139L, 142L, 148N, 149E
CDD
cd00446 (GrpE)

137M

dimer interface
71W, 74S, 75Y, 78K, 79Q, 81D, 82F, 85F, 86T, 87K, 89K, 92E, 93V, 96L, 97R, 100A, 101S, 103K, 104I, 107K, 108L, 109L, 111G, 112L, 113D, 114N, 115L, 117R, 118A, 134G, 135V, 137M, 138I, 139L, 142L, 148N, 149E
CDD
cd00446 (GrpE)

138I

dimer interface
71W, 74S, 75Y, 78K, 79Q, 81D, 82F, 85F, 86T, 87K, 89K, 92E, 93V, 96L, 97R, 100A, 101S, 103K, 104I, 107K, 108L, 109L, 111G, 112L, 113D, 114N, 115L, 117R, 118A, 134G, 135V, 137M, 138I, 139L, 142L, 148N, 149E
CDD
cd00446 (GrpE)

139L

dimer interface
71W, 74S, 75Y, 78K, 79Q, 81D, 82F, 85F, 86T, 87K, 89K, 92E, 93V, 96L, 97R, 100A, 101S, 103K, 104I, 107K, 108L, 109L, 111G, 112L, 113D, 114N, 115L, 117R, 118A, 134G, 135V, 137M, 138I, 139L, 142L, 148N, 149E
CDD
cd00446 (GrpE)

142L

dimer interface
71W, 74S, 75Y, 78K, 79Q, 81D, 82F, 85F, 86T, 87K, 89K, 92E, 93V, 96L, 97R, 100A, 101S, 103K, 104I, 107K, 108L, 109L, 111G, 112L, 113D, 114N, 115L, 117R, 118A, 134G, 135V, 137M, 138I, 139L, 142L, 148N, 149E
CDD
cd00446 (GrpE)

148N

dimer interface
71W, 74S, 75Y, 78K, 79Q, 81D, 82F, 85F, 86T, 87K, 89K, 92E, 93V, 96L, 97R, 100A, 101S, 103K, 104I, 107K, 108L, 109L, 111G, 112L, 113D, 114N, 115L, 117R, 118A, 134G, 135V, 137M, 138I, 139L, 142L, 148N, 149E
CDD
cd00446 (GrpE)

149E

dimer interface
71W, 74S, 75Y, 78K, 79Q, 81D, 82F, 85F, 86T, 87K, 89K, 92E, 93V, 96L, 97R, 100A, 101S, 103K, 104I, 107K, 108L, 109L, 111G, 112L, 113D, 114N, 115L, 117R, 118A, 134G, 135V, 137M, 138I, 139L, 142L, 148N, 149E
CDD
cd00446 (GrpE)
Hsp70 (ATPase doma...

87K

Hsp70 (ATPase domain) interactions
87K, 95E, 117R, 120S, 160Y, 162P, 163M, 165H, 166H, 167A, 168V, 169M, 185L, 194K, 198P, 200M, 203V
CDD
cd00446 (GrpE)

95E

Hsp70 (ATPase domain) interactions
87K, 95E, 117R, 120S, 160Y, 162P, 163M, 165H, 166H, 167A, 168V, 169M, 185L, 194K, 198P, 200M, 203V
CDD
cd00446 (GrpE)

117R

Hsp70 (ATPase domain) interactions
87K, 95E, 117R, 120S, 160Y, 162P, 163M, 165H, 166H, 167A, 168V, 169M, 185L, 194K, 198P, 200M, 203V
CDD
cd00446 (GrpE)

120S

Hsp70 (ATPase domain) interactions
87K, 95E, 117R, 120S, 160Y, 162P, 163M, 165H, 166H, 167A, 168V, 169M, 185L, 194K, 198P, 200M, 203V
CDD
cd00446 (GrpE)

160Y

Hsp70 (ATPase domain) interactions
87K, 95E, 117R, 120S, 160Y, 162P, 163M, 165H, 166H, 167A, 168V, 169M, 185L, 194K, 198P, 200M, 203V
CDD
cd00446 (GrpE)

162P

Hsp70 (ATPase domain) interactions
87K, 95E, 117R, 120S, 160Y, 162P, 163M, 165H, 166H, 167A, 168V, 169M, 185L, 194K, 198P, 200M, 203V
CDD
cd00446 (GrpE)

163M

Hsp70 (ATPase domain) interactions
87K, 95E, 117R, 120S, 160Y, 162P, 163M, 165H, 166H, 167A, 168V, 169M, 185L, 194K, 198P, 200M, 203V
CDD
cd00446 (GrpE)

165H

Hsp70 (ATPase domain) interactions
87K, 95E, 117R, 120S, 160Y, 162P, 163M, 165H, 166H, 167A, 168V, 169M, 185L, 194K, 198P, 200M, 203V
CDD
cd00446 (GrpE)

166H

Hsp70 (ATPase domain) interactions
87K, 95E, 117R, 120S, 160Y, 162P, 163M, 165H, 166H, 167A, 168V, 169M, 185L, 194K, 198P, 200M, 203V
CDD
cd00446 (GrpE)

167A

Hsp70 (ATPase domain) interactions
87K, 95E, 117R, 120S, 160Y, 162P, 163M, 165H, 166H, 167A, 168V, 169M, 185L, 194K, 198P, 200M, 203V
CDD
cd00446 (GrpE)

168V

Hsp70 (ATPase domain) interactions
87K, 95E, 117R, 120S, 160Y, 162P, 163M, 165H, 166H, 167A, 168V, 169M, 185L, 194K, 198P, 200M, 203V
CDD
cd00446 (GrpE)

169M

Hsp70 (ATPase domain) interactions
87K, 95E, 117R, 120S, 160Y, 162P, 163M, 165H, 166H, 167A, 168V, 169M, 185L, 194K, 198P, 200M, 203V
CDD
cd00446 (GrpE)

185L

Hsp70 (ATPase domain) interactions
87K, 95E, 117R, 120S, 160Y, 162P, 163M, 165H, 166H, 167A, 168V, 169M, 185L, 194K, 198P, 200M, 203V
CDD
cd00446 (GrpE)

194K

Hsp70 (ATPase domain) interactions
87K, 95E, 117R, 120S, 160Y, 162P, 163M, 165H, 166H, 167A, 168V, 169M, 185L, 194K, 198P, 200M, 203V
CDD
cd00446 (GrpE)

198P

Hsp70 (ATPase domain) interactions
87K, 95E, 117R, 120S, 160Y, 162P, 163M, 165H, 166H, 167A, 168V, 169M, 185L, 194K, 198P, 200M, 203V
CDD
cd00446 (GrpE)

200M

Hsp70 (ATPase domain) interactions
87K, 95E, 117R, 120S, 160Y, 162P, 163M, 165H, 166H, 167A, 168V, 169M, 185L, 194K, 198P, 200M, 203V
CDD
cd00446 (GrpE)

203V

Hsp70 (ATPase domain) interactions
87K, 95E, 117R, 120S, 160Y, 162P, 163M, 165H, 166H, 167A, 168V, 169M, 185L, 194K, 198P, 200M, 203V
CDD
cd00446 (GrpE)

GO term prediction

Biological Process

GO:0006457 protein folding

Molecular Function

GO:0000774 adenyl-nucleotide exchange factor activity
GO:0042803 protein homodimerization activity
GO:0051087 chaperone binding

Cellular Component