27725_FusoPortal_Gene_1197

Protein

27725_FusoPortal_Gene_1197

Length

328 amino acids

Protein family membership

Acrylyl-CoA reductase AcuI (IPR014188)

Homologous superfamilies

Homologous superfamily
3 - 141
GroES-like superfamily (IPR011032)
Homologous superfamily
117 - 294
NAD(P)-binding domain superfamily (IPR036291)

1 50 100 150 200 250 300 328

Domains and repeats

Domain
159 - 286
Alcohol dehydrogenase, C-terminal (IPR013149)

1 50 100 150 200 250 300 328

Detailed signature matches

IPR011032

GroES-like superfamily
1. SSF50129 (GroES-like)
  
  3 - 141
  
  SUPERFAMILY
  SSF50129 (GroES-like)
IPR036291

NAD(P)-binding domain superfamily
1. SSF51735 (NAD(P)-bi...)
  
  117 - 294
  
  SUPERFAMILY
  SSF51735 (NAD(P)-binding Rossmann-fold domains)
IPR014188

Acrylyl-CoA reductase AcuI
1. TIGR02823
  
  4 - 326
  
  TIGRFAMs
  TIGR02823 (TIGR02823)
2. PTHR43677:SF1 (ACRY...)
  
  2 - 326
  
  PANTHER
  PTHR43677:SF1 (ACRYLYL-COA REDUCTASE ACUI-RELATED)
IPR013149

Alcohol dehydrogenase, C-terminal
1. PF00107 (ADH_zinc_N)
  
  159 - 286
  
  Pfam
  PF00107 (ADH_zinc_N)

no IPR

Unintegrated signatures

G3DSA:3.40.50...

141 - 321

GENE3D
G3DSA:3.40.50.720 (G3DSA:3.40.50.720)
G3DSA:3.90.18...

1 - 140

GENE3D
G3DSA:3.90.180.10 (G3DSA:3.90.180.10)
PTHR43677 (FAMILY N...)

2 - 326

PANTHER
PTHR43677 (FAMILY NOT NAMED)
cd05280 (MDR_yhdh_yhfp)

3 - 327

CDD
cd05280 (MDR_yhdh_yhfp)

Residue annotation

NADP binding site ...

42N

NADP binding site
42N, 43Y, 128T, 129A, 132T, 155G, 157G, 158G, 159G, 160V, 179V, 180N, 181D, 199R, 221T, 222V, 243C, 244G, 245N, 246I, 247A, 269I, 270D, 271S, 272V, 314M, 319L
CDD
cd05280 (MDR_yhdh_yhfp)

43Y

NADP binding site
42N, 43Y, 128T, 129A, 132T, 155G, 157G, 158G, 159G, 160V, 179V, 180N, 181D, 199R, 221T, 222V, 243C, 244G, 245N, 246I, 247A, 269I, 270D, 271S, 272V, 314M, 319L
CDD
cd05280 (MDR_yhdh_yhfp)

128T

NADP binding site
42N, 43Y, 128T, 129A, 132T, 155G, 157G, 158G, 159G, 160V, 179V, 180N, 181D, 199R, 221T, 222V, 243C, 244G, 245N, 246I, 247A, 269I, 270D, 271S, 272V, 314M, 319L
CDD
cd05280 (MDR_yhdh_yhfp)

129A

NADP binding site
42N, 43Y, 128T, 129A, 132T, 155G, 157G, 158G, 159G, 160V, 179V, 180N, 181D, 199R, 221T, 222V, 243C, 244G, 245N, 246I, 247A, 269I, 270D, 271S, 272V, 314M, 319L
CDD
cd05280 (MDR_yhdh_yhfp)

132T

NADP binding site
42N, 43Y, 128T, 129A, 132T, 155G, 157G, 158G, 159G, 160V, 179V, 180N, 181D, 199R, 221T, 222V, 243C, 244G, 245N, 246I, 247A, 269I, 270D, 271S, 272V, 314M, 319L
CDD
cd05280 (MDR_yhdh_yhfp)

155G

NADP binding site
42N, 43Y, 128T, 129A, 132T, 155G, 157G, 158G, 159G, 160V, 179V, 180N, 181D, 199R, 221T, 222V, 243C, 244G, 245N, 246I, 247A, 269I, 270D, 271S, 272V, 314M, 319L
CDD
cd05280 (MDR_yhdh_yhfp)

157G

NADP binding site
42N, 43Y, 128T, 129A, 132T, 155G, 157G, 158G, 159G, 160V, 179V, 180N, 181D, 199R, 221T, 222V, 243C, 244G, 245N, 246I, 247A, 269I, 270D, 271S, 272V, 314M, 319L
CDD
cd05280 (MDR_yhdh_yhfp)

158G

NADP binding site
42N, 43Y, 128T, 129A, 132T, 155G, 157G, 158G, 159G, 160V, 179V, 180N, 181D, 199R, 221T, 222V, 243C, 244G, 245N, 246I, 247A, 269I, 270D, 271S, 272V, 314M, 319L
CDD
cd05280 (MDR_yhdh_yhfp)

159G

NADP binding site
42N, 43Y, 128T, 129A, 132T, 155G, 157G, 158G, 159G, 160V, 179V, 180N, 181D, 199R, 221T, 222V, 243C, 244G, 245N, 246I, 247A, 269I, 270D, 271S, 272V, 314M, 319L
CDD
cd05280 (MDR_yhdh_yhfp)

160V

NADP binding site
42N, 43Y, 128T, 129A, 132T, 155G, 157G, 158G, 159G, 160V, 179V, 180N, 181D, 199R, 221T, 222V, 243C, 244G, 245N, 246I, 247A, 269I, 270D, 271S, 272V, 314M, 319L
CDD
cd05280 (MDR_yhdh_yhfp)

179V

NADP binding site
42N, 43Y, 128T, 129A, 132T, 155G, 157G, 158G, 159G, 160V, 179V, 180N, 181D, 199R, 221T, 222V, 243C, 244G, 245N, 246I, 247A, 269I, 270D, 271S, 272V, 314M, 319L
CDD
cd05280 (MDR_yhdh_yhfp)

180N

NADP binding site
42N, 43Y, 128T, 129A, 132T, 155G, 157G, 158G, 159G, 160V, 179V, 180N, 181D, 199R, 221T, 222V, 243C, 244G, 245N, 246I, 247A, 269I, 270D, 271S, 272V, 314M, 319L
CDD
cd05280 (MDR_yhdh_yhfp)

181D

NADP binding site
42N, 43Y, 128T, 129A, 132T, 155G, 157G, 158G, 159G, 160V, 179V, 180N, 181D, 199R, 221T, 222V, 243C, 244G, 245N, 246I, 247A, 269I, 270D, 271S, 272V, 314M, 319L
CDD
cd05280 (MDR_yhdh_yhfp)

199R

NADP binding site
42N, 43Y, 128T, 129A, 132T, 155G, 157G, 158G, 159G, 160V, 179V, 180N, 181D, 199R, 221T, 222V, 243C, 244G, 245N, 246I, 247A, 269I, 270D, 271S, 272V, 314M, 319L
CDD
cd05280 (MDR_yhdh_yhfp)

221T

NADP binding site
42N, 43Y, 128T, 129A, 132T, 155G, 157G, 158G, 159G, 160V, 179V, 180N, 181D, 199R, 221T, 222V, 243C, 244G, 245N, 246I, 247A, 269I, 270D, 271S, 272V, 314M, 319L
CDD
cd05280 (MDR_yhdh_yhfp)

222V

NADP binding site
42N, 43Y, 128T, 129A, 132T, 155G, 157G, 158G, 159G, 160V, 179V, 180N, 181D, 199R, 221T, 222V, 243C, 244G, 245N, 246I, 247A, 269I, 270D, 271S, 272V, 314M, 319L
CDD
cd05280 (MDR_yhdh_yhfp)

243C

NADP binding site
42N, 43Y, 128T, 129A, 132T, 155G, 157G, 158G, 159G, 160V, 179V, 180N, 181D, 199R, 221T, 222V, 243C, 244G, 245N, 246I, 247A, 269I, 270D, 271S, 272V, 314M, 319L
CDD
cd05280 (MDR_yhdh_yhfp)

244G

NADP binding site
42N, 43Y, 128T, 129A, 132T, 155G, 157G, 158G, 159G, 160V, 179V, 180N, 181D, 199R, 221T, 222V, 243C, 244G, 245N, 246I, 247A, 269I, 270D, 271S, 272V, 314M, 319L
CDD
cd05280 (MDR_yhdh_yhfp)

245N

NADP binding site
42N, 43Y, 128T, 129A, 132T, 155G, 157G, 158G, 159G, 160V, 179V, 180N, 181D, 199R, 221T, 222V, 243C, 244G, 245N, 246I, 247A, 269I, 270D, 271S, 272V, 314M, 319L
CDD
cd05280 (MDR_yhdh_yhfp)

246I

NADP binding site
42N, 43Y, 128T, 129A, 132T, 155G, 157G, 158G, 159G, 160V, 179V, 180N, 181D, 199R, 221T, 222V, 243C, 244G, 245N, 246I, 247A, 269I, 270D, 271S, 272V, 314M, 319L
CDD
cd05280 (MDR_yhdh_yhfp)

247A

NADP binding site
42N, 43Y, 128T, 129A, 132T, 155G, 157G, 158G, 159G, 160V, 179V, 180N, 181D, 199R, 221T, 222V, 243C, 244G, 245N, 246I, 247A, 269I, 270D, 271S, 272V, 314M, 319L
CDD
cd05280 (MDR_yhdh_yhfp)

269I

NADP binding site
42N, 43Y, 128T, 129A, 132T, 155G, 157G, 158G, 159G, 160V, 179V, 180N, 181D, 199R, 221T, 222V, 243C, 244G, 245N, 246I, 247A, 269I, 270D, 271S, 272V, 314M, 319L
CDD
cd05280 (MDR_yhdh_yhfp)

270D

NADP binding site
42N, 43Y, 128T, 129A, 132T, 155G, 157G, 158G, 159G, 160V, 179V, 180N, 181D, 199R, 221T, 222V, 243C, 244G, 245N, 246I, 247A, 269I, 270D, 271S, 272V, 314M, 319L
CDD
cd05280 (MDR_yhdh_yhfp)

271S

NADP binding site
42N, 43Y, 128T, 129A, 132T, 155G, 157G, 158G, 159G, 160V, 179V, 180N, 181D, 199R, 221T, 222V, 243C, 244G, 245N, 246I, 247A, 269I, 270D, 271S, 272V, 314M, 319L
CDD
cd05280 (MDR_yhdh_yhfp)

272V

NADP binding site
42N, 43Y, 128T, 129A, 132T, 155G, 157G, 158G, 159G, 160V, 179V, 180N, 181D, 199R, 221T, 222V, 243C, 244G, 245N, 246I, 247A, 269I, 270D, 271S, 272V, 314M, 319L
CDD
cd05280 (MDR_yhdh_yhfp)

314M

NADP binding site
42N, 43Y, 128T, 129A, 132T, 155G, 157G, 158G, 159G, 160V, 179V, 180N, 181D, 199R, 221T, 222V, 243C, 244G, 245N, 246I, 247A, 269I, 270D, 271S, 272V, 314M, 319L
CDD
cd05280 (MDR_yhdh_yhfp)

319L

NADP binding site
42N, 43Y, 128T, 129A, 132T, 155G, 157G, 158G, 159G, 160V, 179V, 180N, 181D, 199R, 221T, 222V, 243C, 244G, 245N, 246I, 247A, 269I, 270D, 271S, 272V, 314M, 319L
CDD
cd05280 (MDR_yhdh_yhfp)
dimer interface cd...

209P

dimer interface
209P, 236Y, 242T, 243C, 244G, 245N, 251I, 254A, 255N, 256V, 257Y, 259F, 260I, 261L, 264V, 265K, 266L, 267I, 268G, 269I, 270D, 273Q, 274C
CDD
cd05280 (MDR_yhdh_yhfp)

236Y

dimer interface
209P, 236Y, 242T, 243C, 244G, 245N, 251I, 254A, 255N, 256V, 257Y, 259F, 260I, 261L, 264V, 265K, 266L, 267I, 268G, 269I, 270D, 273Q, 274C
CDD
cd05280 (MDR_yhdh_yhfp)

242T

dimer interface
209P, 236Y, 242T, 243C, 244G, 245N, 251I, 254A, 255N, 256V, 257Y, 259F, 260I, 261L, 264V, 265K, 266L, 267I, 268G, 269I, 270D, 273Q, 274C
CDD
cd05280 (MDR_yhdh_yhfp)

243C

dimer interface
209P, 236Y, 242T, 243C, 244G, 245N, 251I, 254A, 255N, 256V, 257Y, 259F, 260I, 261L, 264V, 265K, 266L, 267I, 268G, 269I, 270D, 273Q, 274C
CDD
cd05280 (MDR_yhdh_yhfp)

244G

dimer interface
209P, 236Y, 242T, 243C, 244G, 245N, 251I, 254A, 255N, 256V, 257Y, 259F, 260I, 261L, 264V, 265K, 266L, 267I, 268G, 269I, 270D, 273Q, 274C
CDD
cd05280 (MDR_yhdh_yhfp)

245N

dimer interface
209P, 236Y, 242T, 243C, 244G, 245N, 251I, 254A, 255N, 256V, 257Y, 259F, 260I, 261L, 264V, 265K, 266L, 267I, 268G, 269I, 270D, 273Q, 274C
CDD
cd05280 (MDR_yhdh_yhfp)

251I

dimer interface
209P, 236Y, 242T, 243C, 244G, 245N, 251I, 254A, 255N, 256V, 257Y, 259F, 260I, 261L, 264V, 265K, 266L, 267I, 268G, 269I, 270D, 273Q, 274C
CDD
cd05280 (MDR_yhdh_yhfp)

254A

dimer interface
209P, 236Y, 242T, 243C, 244G, 245N, 251I, 254A, 255N, 256V, 257Y, 259F, 260I, 261L, 264V, 265K, 266L, 267I, 268G, 269I, 270D, 273Q, 274C
CDD
cd05280 (MDR_yhdh_yhfp)

255N

dimer interface
209P, 236Y, 242T, 243C, 244G, 245N, 251I, 254A, 255N, 256V, 257Y, 259F, 260I, 261L, 264V, 265K, 266L, 267I, 268G, 269I, 270D, 273Q, 274C
CDD
cd05280 (MDR_yhdh_yhfp)

256V

dimer interface
209P, 236Y, 242T, 243C, 244G, 245N, 251I, 254A, 255N, 256V, 257Y, 259F, 260I, 261L, 264V, 265K, 266L, 267I, 268G, 269I, 270D, 273Q, 274C
CDD
cd05280 (MDR_yhdh_yhfp)

257Y

dimer interface
209P, 236Y, 242T, 243C, 244G, 245N, 251I, 254A, 255N, 256V, 257Y, 259F, 260I, 261L, 264V, 265K, 266L, 267I, 268G, 269I, 270D, 273Q, 274C
CDD
cd05280 (MDR_yhdh_yhfp)

259F

dimer interface
209P, 236Y, 242T, 243C, 244G, 245N, 251I, 254A, 255N, 256V, 257Y, 259F, 260I, 261L, 264V, 265K, 266L, 267I, 268G, 269I, 270D, 273Q, 274C
CDD
cd05280 (MDR_yhdh_yhfp)

260I

dimer interface
209P, 236Y, 242T, 243C, 244G, 245N, 251I, 254A, 255N, 256V, 257Y, 259F, 260I, 261L, 264V, 265K, 266L, 267I, 268G, 269I, 270D, 273Q, 274C
CDD
cd05280 (MDR_yhdh_yhfp)

261L

dimer interface
209P, 236Y, 242T, 243C, 244G, 245N, 251I, 254A, 255N, 256V, 257Y, 259F, 260I, 261L, 264V, 265K, 266L, 267I, 268G, 269I, 270D, 273Q, 274C
CDD
cd05280 (MDR_yhdh_yhfp)

264V

dimer interface
209P, 236Y, 242T, 243C, 244G, 245N, 251I, 254A, 255N, 256V, 257Y, 259F, 260I, 261L, 264V, 265K, 266L, 267I, 268G, 269I, 270D, 273Q, 274C
CDD
cd05280 (MDR_yhdh_yhfp)

265K

dimer interface
209P, 236Y, 242T, 243C, 244G, 245N, 251I, 254A, 255N, 256V, 257Y, 259F, 260I, 261L, 264V, 265K, 266L, 267I, 268G, 269I, 270D, 273Q, 274C
CDD
cd05280 (MDR_yhdh_yhfp)

266L

dimer interface
209P, 236Y, 242T, 243C, 244G, 245N, 251I, 254A, 255N, 256V, 257Y, 259F, 260I, 261L, 264V, 265K, 266L, 267I, 268G, 269I, 270D, 273Q, 274C
CDD
cd05280 (MDR_yhdh_yhfp)

267I

dimer interface
209P, 236Y, 242T, 243C, 244G, 245N, 251I, 254A, 255N, 256V, 257Y, 259F, 260I, 261L, 264V, 265K, 266L, 267I, 268G, 269I, 270D, 273Q, 274C
CDD
cd05280 (MDR_yhdh_yhfp)

268G

dimer interface
209P, 236Y, 242T, 243C, 244G, 245N, 251I, 254A, 255N, 256V, 257Y, 259F, 260I, 261L, 264V, 265K, 266L, 267I, 268G, 269I, 270D, 273Q, 274C
CDD
cd05280 (MDR_yhdh_yhfp)

269I

dimer interface
209P, 236Y, 242T, 243C, 244G, 245N, 251I, 254A, 255N, 256V, 257Y, 259F, 260I, 261L, 264V, 265K, 266L, 267I, 268G, 269I, 270D, 273Q, 274C
CDD
cd05280 (MDR_yhdh_yhfp)

270D

dimer interface
209P, 236Y, 242T, 243C, 244G, 245N, 251I, 254A, 255N, 256V, 257Y, 259F, 260I, 261L, 264V, 265K, 266L, 267I, 268G, 269I, 270D, 273Q, 274C
CDD
cd05280 (MDR_yhdh_yhfp)

273Q

dimer interface
209P, 236Y, 242T, 243C, 244G, 245N, 251I, 254A, 255N, 256V, 257Y, 259F, 260I, 261L, 264V, 265K, 266L, 267I, 268G, 269I, 270D, 273Q, 274C
CDD
cd05280 (MDR_yhdh_yhfp)

274C

dimer interface
209P, 236Y, 242T, 243C, 244G, 245N, 251I, 254A, 255N, 256V, 257Y, 259F, 260I, 261L, 264V, 265K, 266L, 267I, 268G, 269I, 270D, 273Q, 274C
CDD
cd05280 (MDR_yhdh_yhfp)

GO term prediction

Biological Process

GO:0055114 oxidation-reduction process

Molecular Function

None predicted.

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features

27725_FusoPortal_Gene_1197

Protein family membership

Homologous superfamilies

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component